Hiroyuki Toh

Q: What Schools Are Affiliated With Hiroyuki Toh

Hiroyuki Toh is affiliated with the following schools: Kyushu University, Kwansei Gakuin University, Osaka University

Hiroyuki Toh's AcademicInfluence.com Rankings

Hiroyuki Toh

Biology

#11299

World Rank

#14685

Historical Rank

Systematics

#67

World Rank

#80

Historical Rank

Bioinformatics

#131

World Rank

#133

Historical Rank

Computational Biology

#239

World Rank

#240

Historical Rank

biology Degrees

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Biology

Hiroyuki Toh's Degrees

PhD Biophysics Kyoto University

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Hiroyuki Toh's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MAFFT version 5: improvement in accuracy of multiple sequence alignment (2005) (4494)
Recent developments in the MAFFT multiple sequence alignment program (2008) (3269)
Multiple alignment of DNA sequences with MAFFT. (2009) (1214)
Parallelization of the MAFFT multiple sequence alignment program (2010) (729)
Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung (1991) (566)
Improved accuracy of multiple ncRNA alignment by incorporating structural information into a MAFFT-based framework (2008) (548)
Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus (1983) (401)
Identification of a new cryptochrome class. Structure, function, and evolution. (2003) (305)
Expansion of the zinc metallo‐hydrolase family of the β‐lactamase fold (2001) (278)
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase (1997) (260)
Inference of a genetic network by a combined approach of cluster analysis and graphical Gaussian modeling (2002) (247)
Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. (2013) (213)
Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish (2000) (198)
Retroviral protease-like sequence in the yeast transposon Ty 1 (1985) (195)
Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. (1991) (187)
Molecular cloning and characterization of human caspase-activated DNase. (1998) (179)
Improvement in the accuracy of multiple sequence alignment program MAFFT. (2005) (176)
Archaeal-type rhodopsins in Chlamydomonas: model structure and intracellular localization. (2003) (165)
A novel representation of protein sequences for prediction of subcellular location using support vector machines (2005) (158)
Molecular Evolution of the Photolyase–Blue-Light Photoreceptor Family (1997) (155)
Molecular evolution of receptors for eicosanoids (1995) (152)
The inference of protein-protein interactions by co-evolutionary analysis is improved by excluding the information about the phylogenetic relationships (2005) (142)
A heterodimeric DNA polymerase: evidence that members of Euryarchaeota possess a distinct DNA polymerase. (1998) (138)
Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance (2010) (137)
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. (2011) (130)
Close structural resemblance between putative polymerase of a Drosophila transposable genetic element 17.6 and pol gene product of Moloney murine leukaemia virus. (1985) (127)
Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase. (1999) (121)
Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803. (2000) (120)
PartTree: an algorithm to build an approximate tree from a large number of unaligned sequences (2007) (120)
Functional Interactions of a Homolog of Proliferating Cell Nuclear Antigen with DNA Polymerases inArchaea (1999) (113)
Organization and nucleotide sequence of the DNA polymerase gene from the archaeon Pyrococcus furiosus. (1993) (109)
Leukotriene A4 hydrolase is a zinc-containing aminopeptidase. (1990) (100)
Identification of cryptochrome DASH from vertebrates (2004) (99)
β-carotene hydroxylase gene from the cyanobacterium Synechocystis sp. PCC6803 (1998) (98)
Nucleotide sequence of the Syrian hamster intracisternal A-particle gene: close evolutionary relationship of type A particle gene to types B and D oncovirus genes (1985) (98)
Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold. (2001) (97)
Evolution of influenza virus genes. (1985) (92)
Molecular Evolution of the Myeloperoxidase Family (2000) (89)
[Structural bioinformatics]. (2009) (89)
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. (2010) (87)
Flavin adenine dinucleotide as a chromophore of the Xenopus (6-4)photolyase. (1997) (87)
Structural organization of the gene for prostaglandin D synthase in the rat brain. (1992) (81)
Biochemical Analysis of Replication Factor C from the Hyperthermophilic Archaeon Pyrococcus furiosus (2001) (75)
Structural and Functional Significance of Cysteine Residues of Glutathione-independent Prostaglandin D Synthase (1995) (73)
A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene. (2000) (70)
MOLECULAR EVOLUTION OF THE Ca2+‐BINDING PHOTOPROTEINS OF THE HYDROZOA (1995) (67)
Statistical estimation of cluster boundaries in gene expression profile data (2001) (64)
Molecular evolution of phosphoenolpyruvate carboxylase for C4 photosynthesis in maize: comparison of its cDNA sequence with a newly isolated cDNA encoding an isozyme involved in the anaplerotic function. (1992) (62)
DROP: an SVM domain linker predictor trained with optimal features selected by random forest (2011) (62)
Interaction between intrinsically disordered proteins frequently occurs in a human protein-protein interaction network. (2009) (61)
CLONING, EXPRESSION and SEQUENCE ANALYSIS OF cDNA FOR THE LUCIFERASES FROM THE JAPANESE FIREFLIES, Pyrocoelia tniyako AND Hotaria parvula (1995) (60)
Molecular cloning and expression of human arachidonate 12-lipoxygenase. (1990) (57)
Molecular evolution of biotin-dependent carboxylases. (1993) (56)
Human long-chain acyl-CoA synthetase: structure and chromosomal location. (1992) (53)
A study of archaeal enzymes involved in polar lipid synthesis linking amino acid sequence information, genomic contexts and lipid composition. (2005) (51)
Loop‐length‐dependent SVM prediction of domain linkers for high‐throughput structural proteomics (2009) (51)
Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. (1996) (48)
Sequence similarity between putative gene products of geminiviral DNAs (1984) (46)
Partial correlation coefficient between distance matrices as a new indicator of protein-protein interactions (2006) (46)
Identification of rDNA-specific non-LTR retrotransposons in Cnidaria. (2006) (44)
A comparative study of conservation and variation scores (2010) (44)
Molecular Evolution of the Domain Structures of Protein Disulfide Isomerases (1998) (44)
Molecular Characterization of a Novel Type of Prostamide/Prostaglandin F Synthase, Belonging to the Thioredoxin-like Superfamily* (2008) (43)
ASH structure alignment package: Sensitivity and selectivity in domain classification (2007) (43)
Mutational analysis of the functional motifs of RuvB, an AAA+ class helicase and motor protein for Holliday junction branch migration (2000) (42)
Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma. (2012) (40)
The rs6983267 SNP Is Associated with MYC Transcription Efficiency, Which Promotes Progression and Worsens Prognosis of Colorectal Cancer (2013) (39)
Analysis of membrane stereochemistry with homology modeling of sn-glycerol-1-phosphate dehydrogenase. (2002) (38)
Prediction of interfaces for oligomerizations of G‐protein coupled receptors (2004) (37)
Homology modeling of human leptin/leptin receptor complex. (2000) (37)
Retroviral gag and DNA endonuclease coding sequences in IgE-binding factor gene (1985) (35)
Sequence analysis of firefly luciferase family reveals a conservative sequence motif. (1991) (34)
Molecular cloning and expression of the gene for serine hydroxymethyltransferase from an obligate methylotroph Hyphomicrobium methylovorum GM2. (1993) (33)
VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase‐mediated membrane fusion (2011) (33)
Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase. (1990) (32)
Hjc resolvase is a distantly related member of the type II restriction endonuclease family. (2000) (32)
Mutational Analysis of the Pyrococcus furiosusHolliday Junction Resolvase Hjc Revealed Functionally Important Residues for Dimer Formation, Junction DNA Binding, and Cleavage Activities* (2000) (30)
High-level expression of the photorepair gene in Drosophila ovary and its evolutionary implications. (1994) (29)
Domain Analysis of an Archaeal RadA Protein for the Strand Exchange Activity* (2000) (28)
ASIAN: a web server for inferring a regulatory network framework from gene expression profiles (2005) (28)
Three novel repetitive units of reelin. (2001) (27)
System for Automatically Inferring a Genetic Netwerk from Expression Profiles (2002) (27)
Detecting local structural similarity in proteins by maximizing number of equivalent residues (2004) (27)
Prostaglandin endoperoxide synthase contains an EGF‐like domain (1989) (25)
Cloning and sequence analysis of the gene for phosphoenolpyruvate carboxylase from an extreme thermophile, Thermus sp. (1995) (25)
Molecular evolution of cyclooxygenase and lipoxygenase. (1992) (24)
Membrane Interactive α-Helices in GPCRs as a Novel Drug Target (2006) (23)
GASH: An improved algorithm for maximizing the number of equivalent residues between two protein structures (2005) (23)
Putative mechanism of natural transformation as deduced from genome data. (1999) (22)
Deduction of a gene regulatory relationship framework from gene expression data by the application of graphical Gaussian modeling (2003) (22)
GRIP: A server for predicting interfaces for GPCR oligomerization (2009) (22)
Cloning and expression of the gene for hydroxypyruvate reductase (D-glycerate dehydrogenase from an obligate methylotroph Hyphomicrobium methylovorum GM2. (1994) (21)
Computational prediction and experimental characterization of a "size switch type repacking" during the evolution of dengue envelope protein domain III (ED3). (2014) (20)
Sequence similarity between EGF receptor and α1-acid glycoprotein (1985) (20)
FANCD2 mRNA Overexpression is a Bona Fide Indicator of Lymph Node Metastasis in Human Colorectal Cancer (2010) (20)
Relative von Neumann Entropy for Evaluating amino acid conservation (2010) (18)
Evolution of interferon genes. (1985) (15)
Prediction of Protein-Protein Interactions from Phylogenetic Trees Using Partial Correlation Coefficient (2003) (15)
Beta-carotene hydroxylase gene from the cyanobacterium Synechocystis sp. PCC6803. (1998) (15)
Introduction of a distance cut-off into structural alignment by the double dynamic programming algorithm (1997) (15)
A method for comparing circular genomes from gene locations: application to mitochondrial genomes (1998) (14)
ASIAN: a website for network inference (2004) (14)
Is the AIDS virus recombinant? (1985) (13)
Molecular evolution of enzymes involved in the arachidonic acid cascade (1992) (13)
Two novel genes expressed in Xenopus germ line: Characteristic features of putative protein structures, their gene expression profiles and their possible roles in gametogenesis and embryogenesis (2002) (13)
Escherichia coli DNA polymerase II is homologous to α-like DNA polymerases (1991) (13)
Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24 (2012) (13)
Gtr1p differentially associates with Gtr2p and Ego1p. (2009) (12)
A local structural alignment method that accommodates with circular permutation (2001) (12)
GRIPDB - G protein coupled Receptor Interaction Partners DataBase (2011) (12)
SeSAW: balancing sequence and structural information in protein functional mapping (2010) (11)
Recruitment of thioredoxin-like domains into prostaglandin synthases. (2008) (11)
N-terminal halves of gramicidin S synthetase 1, and tyrocidine synthetase 1 as novel members of firefly luciferase family. (1990) (11)
Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. (2010) (11)
Functional annotation by sequence‐weighted structure alignments: Statistical analysis and case studies from the Protein 3000 structural genomics project in Japan (2008) (11)
Evolutionary Analysis of Functional Divergence among Chemokine Receptors, Decoy Receptors, and Viral Receptors (2012) (10)
Computational and experimental analyses of furcatin hydrolase for substrate specificity studies of disaccharide-specific glycosidases. (2008) (9)
GGIP: Structure and sequence‐based GPCR–GPCR interaction pair predictor (2016) (9)
Genomics and computational science for virus research (2013) (9)
ASIAN: Automatic System for Inferring a Network from Gene Expression Profiles (2001) (9)
Positive Selection in the ComC-ComD System of Streptococcal Species (2006) (8)
Molecular Phylogenetic Analysis of Class A GPCR (2001) (8)
A graphical chain model for inferring regulatory system networks from gene expression profiles (2006) (8)
Membrane interactive alpha-helices in GPCRs as a novel drug target. (2006) (8)
Escherichia coli DNA polymerase II is homologous to alpha-like DNA polymerases. (1991) (7)
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase (1999) (7)
Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics (2012) (6)
Human genes for prostaglandin endoperoxide synthase-2, thromboxane synthase and prostacyclin synthase. (1995) (6)
Role of Mg2+ in the ribozyme system (1987) (6)
ASIAN: A Web Site for Network Inference (2003) (6)
Molecular Evolution of Phosphoenolpyruvate Carboxylase for C4 Photosynthesis in Maize (1992) (4)
Loop Length Dependent SVM Prediction of Domain Linkers (2008) (4)
MicroRNA-Ago2 Complex in Mature Human Red Blood Cells. (2009) (4)
Two-Layered Genetic Network Drawings with Minimum Edge Crossings (2001) (3)
Cloning and characterization of human cyclooxygenase gene and primary structure of the enzyme. (1991) (3)
Identification of New Members of the GS ADP-Forming Family from the De Novo Purine Biosynthesis Pathway (1999) (3)
Visualization of Genetic Networks: Edge Crossing Minimization of a Graph Drawing with Vertex Pairs (2000) (3)
T7 and E.coli share homology for replication‐related gene products (1986) (3)
Clinical Studies Plastin 3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial – Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis (2013) (3)
How does a topological inversion change the evolutionary constraints on membrane proteins? (2004) (3)
Analysis of Asymmetry of Membrane Proteins by Evolutionary Trace (2002) (2)
Adenylosuccinate synthetase genes: molecular cloning and phylogenetic analysis of a highly conserved archaeal gene. (1998) (2)
Protein Sequence-Structure Alignment Using 3 D-HMM (2004) (2)
A Procedure for Estimating Cluster Boundaries in Gene Expression Profile Data (2000) (2)
Functional expression of single-chain antibody to leukotriene C(4). (2010) (2)
Update of the GRIP web service (2020) (2)
Implementing LOD Surfer as a Search System for the Annotation of Multiple Protein Sequence Alignment (2018) (2)
Sequence similarity between EGF receptor and alpha 1-acid glycoprotein. (1985) (2)
Phylogenetic Footprinting (2019) (2)
Prediction of Interfaces for GPCR Oligomer (2003) (1)
1.10 – Molecular Evolution of Proteins Involved in the Arachidonic Acid Cascade (1999) (1)
[Molecular evolution of protein function]. (2001) (1)
S08I2 Functional Annotation Sequence-weighted Structure Alignments(Bioinformatics in the Era of Structural Proteomics) (2007) (1)
A Web Server for GPCR-GPCR Interaction Pair Prediction (2022) (1)
Homology between IgE-binding factor and retrovirus genes (1986) (1)
Prediction of Structures and Functions of Proteins by Database Searching (1999) (1)
Inference of Genetic Networks from Expression Profile by Graphical Gaussian Modeling (2000) (0)
1P472 Domain linker prediction using a Support Vector Machine(SVM)(23. Bioinformatics, genomics and proteomics (I),Poster Session,Abstract,Meeting Program of EABS &BSJ 2006) (2006) (0)
System for automatically inferring a genetic network from gene expression profiles (2001) (0)
S08I5 Computational Analysis of Protein-Protein Interaction(Bioinformatics in the Era of Structural Proteomics) (2007) (0)
Molecular Characterization of Prostamide/Prostaglandin F Synthase: A Novel Enzyme Belonging to the Thioredoxin Superfamily (2008) (0)
Homology Search and Prediction of Biological Function of Protein from Amino Acid Sequences (1993) (0)
Cyclooxygenases (prostaglandin H synthases): structure and evolutionary aspects (2015) (0)
S3c2-3 Prediction of protein-protein interaction with co-evolutionary information(S3-c2: "Structural Bioinformatics: Molecular structures as the basis of understanding protein network systems",Symposia,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
Reverse Transcriptase-containing DNA Viruses and Plasmids Lack Integrase (1985) (0)
Assignment of Direct Binding in Gene Regulatory Systems from Expression Profiles (2002) (0)
Correspondence between a Genetic Network Inferred from Expression Profiles by Strategic Gene Disruptions and the Known Regulatory Relationships (2001) (0)
3P280 Prediction of interafaces for oligomerizations of G-protein coupled receptors (2004) (0)
Design of a fold recognition method by utilizing the alignments based on structural comparison. (1999) (0)
1P481 Real-time Structure Based Queries at the Protein Data Bank japan(23. Bioinformatics, genomics and proteomics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
[Extraction of information about protein interaction using evolutionary trace]. (2002) (0)
Prediction of Cancer-Associated Hotspot Mutations that Affect GPCR Oligomerization (2017) (0)
2P-236 An SVM-Domain Linker Prediction Trained with Optimized Features Selected by Random Forest(Bioinformatics:Structural genomics,The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
[Homology search and molecular evolution: detection of genes encoding reverse transcriptase from several viruses and transposons]. (1986) (0)
/ 1-Carotene Hydroxylase Gene from PCC 6803 theCyanobacterium Synechocystis sp . (2018) (0)
Modification of ASIAN: Deduction of a Framework of Gene Regulatory Systems from Expression Profile Data (2002) (0)
Structural Equation Modeling for Systems Biology (2015) (0)
2P432 A novel statistical prediction method for multiple protein-protein interaction interfaces(48. Bioinformatics, genomics and proteomics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
2P059 Comparison of Different Profiles for the Analysis of Interface of Protein-Protein Interaction(Proteins-structure and structure-function relationship,Poster Presentations) (2007) (0)
Identification of the molecule which was expressed at mitotic to meiotic phase conversion in Xenopus laevis (1998) (0)
[Interface prediction for class A GPCR oligomers]. (2005) (0)
[Molecular structure and evolution of cyclooxygenase and lipoxygenase]. (1992) (0)
Inference of a Genetic Network with Use of a Hierarchical Clustering from a Large Amount of Gene Expression Data. (2002) (0)
Prediction of Protein-Protein Interactions by Using Co-Evolutionary Information (2007) (0)
Molecular evolutionary studies on prostaglandin D synthase (1996) (0)
2P073 Quantitative analysis of conservation of amino acid residues critical for protein-protein interaction(30. Protein function (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) (2006) (0)
Application of quantum chemistry to biology: Some new currents. (1988) (0)
Profile comparison revealed deviation from structural constraint at the positively selected sites (2016) (0)
Inference of Protein-Protein Interactions by Using Co-evolutionary Information (2007) (0)
ASIAN web interface, through which expression profiles can be uploaded for hierarchical clustering w (2011) (0)
Development of HocDB (Homology-Based Clustering DataBase), a Sequence Classification System for Database Searching (2003) (0)
External Referees (2005) (0)
Prediction of GPCR-GPCR interaction with sequence and structure information by Autoencoder (2019) (0)
1P244 Loop length dependent SVM prediction of domain linkers(Bioinformatics-structural, functional, and comparative genomics,Oral Presentations) (2007) (0)
3D-keynote for structurally and functionally similar pbHTH modules. (1999) (0)
2TP4-01 An SVM-Domain Linker Prediction Trained with Optimized Features Selected by Random Forest(The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
Circumstances surrounding Japan's bioinformatics human resources : Findings from a survey on human resources (2014) (0)
1SA1-03 Prediction of protein-protein interaction with co-evolutionary information(1SA1 Co-evolutionary analyses as the methods to investigate protein-protein interaction,The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
2P-235 A method for coarse level description of sequence and structure for the analysis of protein function(Bioinformatics:Structural genomics,The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
Computational analysis of ligand recognition mechanisms by prostaglandin E2 (subtype 2) and D2 receptors (2011) (0)
3TP1-01 Web services to investigate GPCR oligomerization(The 47th Annual Meeting of the Biophysical Society of Japan) (2009) (0)
[Interface re-engineering as an evolutionary mechanism of protein function]. (2002) (0)
Constraint of Base Pairing on HDV Genome Evolution (2021) (0)
Two Types of Arachidonate 12-Lipoxygenase Demonstrated by Enzymological Immunological and Molecular Biological Studies (1991) (0)
2P-298 Improvement of SVM prediction of domain linker regions(The 46th Annual Meeting of the Biophysical Society of Japan) (2008) (0)
Evolutionary analysis of non-coding regions of domesticated LTR retroelements (2015) (0)
P-360 DISTIRIBUTION AND EVOLUTION OF DISACCHARIDE-SPECIFIC GLYCOSIDASES (DIGLYCOSIDASES) IN PLANTS (2006) (0)
Crystal structure of Dengue 4 Envelope protein domain III (ED3) (2014) (0)
1E1612 A method to select homologous sequences appropriate for functional region prediction by spatial statistics with structure information(Genome biology, Bioinformatics,The 49th Annual Meeting of the Biophysical Society of Japan) (2011) (0)
Comparison of Prediction Methods for Protein-Protein Interactions Using CoEvolutionary Information (2005) (0)
Archaeal-type opsin in Chlamydomonas (2001) (0)
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis (2010) (0)
Crystal Structure Analysis of Synechocystis sp. PCC6803 cryptochrome (2003) (0)
[Molecular evolution of enzymes involved in arachidonate cascade]. (1991) (0)
Arachidonate 12-Lipoxygenases: Enzymology and Molecular Biology (1993) (0)
Expression of a single-chain antibody that neutralizes the effect of cysteinyl leukotrienes (2011) (0)
Corrigendum: A Web Server for GPCR-GPCR Interaction Pair Prediction (2022) (0)
Improvement in the Prediction of Disease-Gene Relationship by the Recommend Algorithm and its Application (2017) (0)
Molecular phylogenetic analysis of pulmonary surfactant protein-C and the relatives (2004) (0)
[Sequence comparison analysis; application to protein engineering]. (1992) (0)
2P270 GGIP : GPCR-GPCR Interaction Pair Predictor(22A. Bioinformatics:Structural genomics,Poster) (2014) (0)

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What Schools Are Affiliated With Hiroyuki Toh?

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Hiroyuki Toh's Degrees

Why Is Hiroyuki Toh Influential?

Hiroyuki Toh's Published Works

Published Works

What Schools Are Affiliated With Hiroyuki Toh?

Hiroyuki Toh's AcademicInfluence.com Rankings