Hitoshi Shimano
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Computer Science
Hitoshi Shimano's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Hitoshi Shimano's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. (2009) (2421)
- Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. (1996) (830)
- Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. (1997) (800)
- Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. (1997) (779)
- Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. (1998) (695)
- Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. (2001) (692)
- Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes* (1999) (675)
- Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. (1998) (655)
- Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. (2007) (569)
- Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter (2001) (526)
- SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology (2017) (510)
- Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance (2007) (471)
- Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. (1997) (451)
- Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements* (2002) (423)
- Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP‐1 suppression (2003) (404)
- TGF-β activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN (2009) (397)
- Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver* (1998) (376)
- A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids* (1999) (369)
- Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes DOI 10.1194/jlr.M100417-JLR200 (2002) (353)
- Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice* (2002) (351)
- Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL (2001) (344)
- SREBPs suppress IRS-2-mediated insulin signalling in the liver (2004) (309)
- Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. (2003) (273)
- Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα (2002) (264)
- Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene* (2000) (252)
- Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. (2005) (229)
- HbA1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study (2011) (224)
- Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor* (2001) (220)
- Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: a meta-analysis. (2011) (213)
- Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. (2001) (208)
- Comparisons of the strength of associations with future type 2 diabetes risk among anthropometric obesity indicators, including waist-to-height ratio: a meta-analysis. (2012) (207)
- SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. (2017) (203)
- Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice. (2004) (202)
- p53 Activation in Adipocytes of Obese Mice* (2003) (197)
- Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL. (1999) (192)
- Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. (2003) (191)
- MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice (2013) (190)
- Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. (2002) (187)
- FEEL-1 and FEEL-2 Are Endocytic Receptors for Advanced Glycation End Products* (2003) (187)
- PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. (2003) (186)
- The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. (2009) (183)
- Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia* (2000) (182)
- Diabetes and risk of hearing impairment in adults: a meta-analysis. (2013) (178)
- TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes (2006) (174)
- SREBPs: physiology and pathophysiology of the SREBP family (2009) (166)
- Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. (2003) (166)
- Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP. (2008) (161)
- Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. (1997) (153)
- Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level* (2000) (152)
- Influence of Fat and Carbohydrate Proportions on the Metabolic Profile in Patients With Type 2 Diabetes: A Meta-Analysis (2009) (151)
- SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes* (2004) (149)
- Elovl6 promotes nonalcoholic steatohepatitis (2012) (142)
- Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. (1995) (138)
- Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. (1992) (137)
- Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha. (2002) (136)
- Elovl6: a new player in fatty acid metabolism and insulin sensitivity (2009) (134)
- Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages. (1990) (133)
- Effect of web-based lifestyle modification on weight control: a meta-analysis (2012) (131)
- Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism. (2002) (130)
- Transcriptional Regulation of the ATP Citrate-lyase Gene by Sterol Regulatory Element-binding Proteins* (2000) (130)
- Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit* (2010) (124)
- p53 Involvement in the Pathogenesis of Fatty Liver Disease* (2004) (124)
- Association Between Physical Activity and Risk of All-Cause Mortality and Cardiovascular Disease in Patients With Diabetes (2013) (123)
- Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver* (2007) (122)
- Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice. (2001) (117)
- Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. (2008) (116)
- Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency. (1991) (115)
- Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases. (2002) (114)
- Early Embryonic Lethality Caused by Targeted Disruption of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Gene* (2003) (112)
- SREBP-1-independent regulation of lipogenic gene expression in adipocytes Published, JLR Papers in Press, April 24, 2007. (2007) (109)
- Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia. (1993) (108)
- p57Kip2 Regulates Actin Dynamics by Binding and Translocating LIM-kinase 1 to the Nucleus* (2003) (101)
- Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B. (1992) (100)
- SCAP is required for timely and proper myelin membrane synthesis (2009) (100)
- Mouse Elovl-6 promoter is an SREBP target. (2008) (93)
- Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity. (2008) (88)
- Mutational analysis of human lipoprotein lipase by carboxy-terminal truncation. (1993) (88)
- Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets (2008) (88)
- Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. (1992) (88)
- Effect of Postmenopausal Status and Age at Menopause on Type 2 Diabetes and Prediabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17) (2013) (87)
- Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. (2002) (84)
- The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential (2019) (84)
- MafB promotes atherosclerosis by inhibiting foam-cell apoptosis (2014) (83)
- Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver. (2000) (83)
- HbA1c variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2 (2012) (83)
- Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells (2005) (82)
- Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells. (2006) (82)
- Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance* (2008) (82)
- Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits. (1989) (79)
- Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages (2018) (79)
- Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization (2013) (77)
- Plasma apolipoproteins in patients with multi-infarct dementia. (1989) (77)
- KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. (2016) (77)
- Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography. (1991) (75)
- Expression of M-CSF receptor encoded by c-fms on smooth muscle cells derived from arteriosclerotic lesion. (1992) (73)
- Sterol Regulatory Element-binding Protein-2 Interacts with Hepatocyte Nuclear Factor-4 to Enhance Sterol Isomerase Gene Expression in Hepatocytes* (2003) (72)
- Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency (1991) (71)
- Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake. (1990) (71)
- Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance (1999) (70)
- Insulin Up-regulates Tumor Necrosis Factor-α Production in Macrophages through an Extracellular-regulated Kinase-dependent Pathway* (2001) (70)
- Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol (2006) (70)
- Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit (2001) (67)
- Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. (2002) (67)
- Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity. (2001) (66)
- Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function. (1993) (66)
- Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice (2013) (66)
- Insulin Inhibits Apoptosis of Macrophage Cell Line, THP-1 Cells, via Phosphatidylinositol-3-Kinase–Dependent Pathway (2002) (65)
- Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia. (2009) (65)
- Effects of pitavastatin (LIVALO tablet) on the estimated glomerular filtration rate (eGFR) in hypercholesterolemic patients with chronic kidney disease. Sub-analysis of the LIVALO Effectiveness and Safety (LIVES) Study. (2010) (64)
- Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. (2013) (64)
- Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. (2006) (64)
- The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. (2010) (63)
- Screening for pre‐diabetes to predict future diabetes using various cut‐off points for HbA1c and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4) (2012) (63)
- Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. (1992) (63)
- Increased Risk Factors for Coronary Artery Disease in Japanese Subjects With Hyperinsulinemia or Glucose Intolerance (1994) (63)
- Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits. (1990) (62)
- Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. (2010) (62)
- Molecular mechanisms involved in hepatic steatosis and insulin resistance (2011) (61)
- Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats. (2003) (60)
- In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis (2015) (60)
- Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor (2005) (60)
- Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice (2014) (59)
- Absence of Hormone-sensitive Lipase Inhibits Obesity and Adipogenesis in Lepob/ob Mice* (2004) (59)
- Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. (2003) (58)
- Scavenger Receptor Expressed by Endothelial Cells I (SREC-I) Mediates the Uptake of Acetylated Low Density Lipoproteins by Macrophages Stimulated with Lipopolysaccharide* (2004) (58)
- Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages. (2004) (57)
- Induction of LDL receptor-related protein during the differentiation of monocyte-macrophages. Possible involvement in the atherosclerotic process. (1994) (55)
- Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice. (1994) (54)
- Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy. (2015) (54)
- Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target. (2008) (53)
- CREBH Regulates Systemic Glucose and Lipid Metabolism (2018) (53)
- Detection of three separate DNA polymorphisms in the human lipoprotein lipase gene by gene amplification and restriction endonuclease digestion. (1992) (52)
- Platelet-derived growth factor induces c-fms and scavenger receptor genes in vascular smooth muscle cells. (1992) (52)
- Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice (2016) (52)
- HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes. (2002) (51)
- Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients. (2015) (51)
- Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy (2006) (50)
- Comparative Binding Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs – An Ab Initio Fragment Molecular Orbital Study (2016) (50)
- Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells. (2005) (48)
- SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling (2007) (48)
- Comparison of Various Lipid Variables as Predictors of Coronary Heart Disease in Japanese Men and Women With Type 2 Diabetes (2012) (47)
- New evidence on pitavastatin: efficacy and safety in clinical studies (2010) (47)
- Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood (2018) (47)
- Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes. (2018) (46)
- Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly. (2007) (46)
- Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice. (2005) (45)
- Cholesteryl ester transfer protein deficiency caused by a nonsense mutation detected in the patient's macrophage mRNA. (1993) (45)
- Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia. (1993) (44)
- MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo (2014) (44)
- Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα. (2018) (44)
- Macrophage colony-stimulating factor regulates both activities of neutral and acidic cholesteryl ester hydrolases in human monocyte-derived macrophages. (1993) (43)
- Ligand-Activated PPARα-Dependent DNA Demethylation Regulates the Fatty Acid β-Oxidation Genes in the Postnatal Liver (2014) (42)
- A transcription factor of lipid synthesis, sterol regulatory element‐binding protein (SREBP)‐1a causes G1 cell‐cycle arrest after accumulation of cyclin‐dependent kinase (cdk) inhibitors (2007) (42)
- CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα (2016) (42)
- PPARγ ligands, troglitazone and pioglitazone, up‐regulate expression of HMG‐CoA synthase and HMG‐CoA reductase gene in THP‐1 macrophages (2002) (42)
- Development of a new scoring system for predicting the 5 year incidence of type 2 diabetes in Japan: the Toranomon Hospital Health Management Center Study 6 (TOPICS 6) (2012) (42)
- High risk of failing eradication of Helicobacter pylori in patients with diabetes: a meta-analysis. (2014) (41)
- Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes. (2014) (41)
- Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects. (2003) (41)
- Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout. (2012) (41)
- Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus. (2013) (41)
- Involvement of glomerular SREBP-1c in diabetic nephropathy. (2007) (41)
- Impact of psychological stress caused by the Great East Japan Earthquake on glycemic control in patients with diabetes. (2012) (39)
- Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11). (2013) (39)
- Elimination of Cholesterol Ester from Macrophage Foam Cells by Adenovirus-mediated Gene Transfer of Hormone-sensitive Lipase* (2002) (39)
- Longitudinal Trajectories of HbA1c and Fasting Plasma Glucose Levels During the Development of Type 2 Diabetes (2012) (39)
- Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver Published, JLR Papers in Press, June 1, 2006. (2006) (39)
- Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. (2013) (38)
- Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice. (2017) (37)
- The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice (2018) (36)
- Occurrence of multiple aberrantly spliced mRNAs upon a donor splice site mutation that causes familial lipoprotein lipase deficiency. (1991) (36)
- Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD. (2012) (36)
- Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice (2011) (35)
- Receptor-Type Protein Tyrosine Phosphatase ϵ (PTPϵM) is a Negative Regulator of Insulin Signaling in Primary Hepatocytes and Liver (2005) (34)
- Efficacy and safety of pitavastatin in Japanese patients with hypercholesterolemia: LIVES study and subanalysis (2011) (34)
- Low lung function and risk of type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 9 (TOPICS 9). (2012) (32)
- Elevated serum and urinary thrombomodulin levels in patients with non-insulin-dependent diabetes mellitus. (1994) (32)
- SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status (2007) (32)
- Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüppel‐Like Factor 4 (AMPK/KLF4) Signaling (2016) (32)
- High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding. (2005) (32)
- Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice (2017) (31)
- SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing. (2008) (31)
- TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. (2013) (30)
- Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes (2014) (30)
- Adiponectin and adiponectin receptors in human pheochromocytoma. (2009) (30)
- Quality of Internet information related to the Mediterranean diet (2011) (30)
- Effect of Aerobic Exercise Training on Serum Levels of High-Density Lipoprotein Cholesterol (2015) (30)
- Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin (2010) (30)
- Network meta‐analysis of the relative efficacy of bariatric surgeries for diabetes remission (2018) (30)
- High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8) (2012) (30)
- Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice (2020) (30)
- Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells. (2013) (30)
- Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism (2019) (29)
- Sterol regulatory element–binding protein‐1c and pancreatic β‐cell dysfunction (2007) (29)
- Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system (2016) (28)
- TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice. (2012) (28)
- Effects of human recombinant macrophage colony-stimulating factor on the secretion of lipoprotein lipase from macrophages. (1991) (28)
- Isoform 1 c of Sterol Regulatory Element Binding Protein Is Less Active Than Isoform 1 a in Livers of Transgenic Mice and in Cultured Cells (2013) (28)
- Sterol Regulatory Element-binding Proteins Activate Insulin Gene Promoter Directly and Indirectly through Synergy with BETA2/E47* (2005) (27)
- Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice (2011) (27)
- Cross-Talk between Peroxisome Proliferator-Activated Receptor ( PPAR ) and Liver X Receptor ( LXR ) in Nutritional Regulation of Fatty Acid Metabolism (2003) (26)
- Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression (2016) (26)
- A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid. (2014) (26)
- Apolipoprotein E Polymorphism Is Associated With Plasma Cholesterol Response in a 7-day Hospitalization Study for Metabolic and Dietary Control in NIDDM (1993) (26)
- Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome (2019) (25)
- The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis (2013) (25)
- Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes. (2005) (25)
- Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization (2016) (25)
- Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis (2006) (24)
- Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis. (2019) (24)
- Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. (2017) (24)
- Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis (2014) (24)
- A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling (2017) (24)
- The enhanced cellular uptake of very-low-density lipoprotein enriched in apolipoprotein E. (1991) (24)
- Development of a screening score for undiagnosed diabetes and its application in estimating absolute risk of future type 2 diabetes in Japan: Toranomon Hospital Health Management Center Study 10 (TOPICS 10). (2013) (23)
- Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice* (2011) (22)
- Protein Residue Networks from Energetic and Geometric Data: Are They Identical? (2018) (22)
- Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42) (2017) (22)
- Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction. (2007) (22)
- Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways. (2012) (22)
- Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver. (2005) (21)
- Role of Monocyte Colony-Stimulating Factor in Foam Cell Generation (1992) (21)
- Fasting Plasma Glucose Levels During the Development of Type 2 Diabetes The Toranomon Hospital Health Management Center Study 7 (TOPICS 7) (2012) (21)
- Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes (2020) (21)
- WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney. (2004) (21)
- Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr−/− mouse model (2015) (21)
- Overexpression of Apolipoprotein E Prevents Development of Diabetic Hyperlipidemia in Transgenic Mice (1995) (21)
- Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E. (1998) (21)
- Platelet-derived growth factor BB-dimer suppresses the expression of macrophage colony-stimulating factor in human vascular smooth muscle cells. (1992) (20)
- Dual regulation of mouse D 5-and D 6-desaturase gene expression by SREBP-1 and PPAR a (2002) (20)
- Critical role of CREBH‐mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells (2017) (20)
- Use of high‐normal levels of haemoglobin A1C and fasting plasma glucose for diabetes screening and for prediction: a meta‐analysis (2013) (20)
- Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity (2017) (20)
- Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysis. (2012) (20)
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- SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy. (2009) (18)
- In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression. (2007) (17)
- Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma (2012) (17)
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- Cholesterol-free diet with a high ratio of polyunsaturated to saturated fatty acids in heterozygous familial hypercholesterolemia: significant lowering effect on plasma cholesterol. (1990) (17)
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- Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promotor in transgenic mice (1991) (16)
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- Novel non‐alcoholic steatohepatitis model with histopathological and insulin‐resistant features (2018) (16)
- Diabetes mellitus and risk of new‐onset and recurrent heart failure: a systematic review and meta‐analysis (2020) (16)
- Cyclin-dependent Kinase Inhibitor , p 21 WAF 1 / CIP 1 , Is Involved in Adipocyte Differentiation and Hypertrophy , Linking to Obesity , and Insulin Resistance * (2008) (15)
- A Large-Scale Survey on Cardio-Cerebrovascular Events During Pitavastatin(LIVALO Tablet)Therapy in Japanese Patients with Hypercholesterolemia ―LIVALO Effectiveness and Safety Study Extension (LIVES Study Extension)― (2011) (15)
- Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance (2018) (15)
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- Suppression of the Pancreatic Duodenal Homeodomain Transcription Factor-1 (Pdx-1) Promoter by Sterol Regulatory Element-binding Protein-1c (SREBP-1c)* (2011) (14)
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- Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion. (2014) (14)
- The Effects of Telenursing with Goal Attainment Scaling in Diabetic Patients: A Case Report (2015) (14)
- Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques (2022) (14)
- A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population. (2015) (13)
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- Abdominal Irradiation Ameliorates Obesity in ob/ob Mice (2007) (12)
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- Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation (2018) (11)
- High-cholesterol diet-induced lipoproteins stimulate lipoprotein lipase secretion in cultured rat alveolar macrophages. (1987) (11)
- ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma (2021) (11)
- Homozygous Familial Hypercholesterolemia (2021) (11)
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- High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding* (2005) (10)
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- Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition (2020) (10)
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- Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients. (2014) (9)
- GLUT12: a second insulin‐responsive glucose transporters as an emerging target for type 2 diabetes (2011) (9)
- CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms (2020) (9)
- A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C‐FOS in hepatocytes (2018) (9)
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- Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1. (2019) (8)
- Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice (2016) (8)
- A kindred of familial acromegaly without evidence for linkage to MEN-1 locus. (2002) (8)
- A case of acute adrenal insufficiency unmasked during sunitinib treatment for metastatic renal cell carcinoma. (2012) (8)
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- Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis (2018) (7)
- Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice. (2009) (7)
- Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes (2015) (7)
- Higher pulse pressure predicts initiation of dialysis in Japanese patients with diabetes (2019) (7)
- Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering (2017) (7)
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- Rapid manipulation of mitochondrial morphology in a living cell with iCMM (2021) (6)
- Association of living alone with the presence of undiagnosed diabetes in Japanese men: the role of modifiable risk factors for diabetes: Toranomon Hospital Health Management Center Study 13 (TOPICS 13) (2013) (6)
- Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle (2021) (6)
- Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta‐analysis (2021) (6)
- Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. (2007) (6)
- Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes (2021) (6)
- Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits. (1997) (5)
- Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non‐alcoholic steatohepatitis model (2020) (5)
- Prevalence of Germline Variants in a Large Cohort of Japanese Patients with Pheochromocytoma and/or Paraganglioma (2021) (5)
- Macrophages rely on extracellular serine to suppress aberrant cytokine production (2021) (5)
- Tetsuya Effects on CD 36 Expression and HDL Knockout Mice : Pleiotropic − Troglitazone Inhibits Atherosclerosis in Apolipoprotein (2001) (5)
- HMG-CoA Reductase Deficiency in Mice 1 Early embryonic lethality caused by targeted disruption of the HMG-CoA reductase gene (2003) (5)
- The release of hepatic triglyceride lipase from rat monolayered hepatocytes in primary culture. (1990) (5)
- ASSOCIATION OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL LEVELS IN PITAVASTATIN TREATMENT WITH RISK OF CARDIO-CEREBROVASCULAR EVENTS IN JAPANESE PATIENTS WITH DYSLIPIDEMIA: ANALYSIS FROM THE LIVES EXTENSION (2011) (4)
- Advanced Oxidation Protein Products Contribute to Renal Tubulopathy via Perturbation of Renal Fatty Acids. (2020) (4)
- Transgenic Mice Overexpressing Nuclear SREBP-1 c in Pancreatic-Cells (2005) (4)
- Overexpression of low density lipoprotein receptor on Chinese hamster ovary cells generates foam cells. (1991) (4)
- Transgenic Mouse and Gene Therapy (1996) (4)
- Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice. (1991) (4)
- Title MicroRNA-33 b knockin mice for an intron of sterol regulatory element-binding factor 1 ( Srebf 1 ) exhibit reduced HDLC in vivo (2017) (4)
- Novel role for the CRTC2 in lipid homeostasis (2016) (4)
- Rho‐associated, coiled‐coil‐containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis (2019) (4)
- Metabolism of chylomicron remnants in transgenic mice expressing apolipoprotein E in the intestine. (1994) (4)
- ApoAII controversy still in rabbit? (2009) (4)
- ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma (2022) (4)
- TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2 (2022) (4)
- Effect of exogenous apo E on the cellular binding of lipoproteins. (1990) (3)
- Oxidative stress and LXR agonist induce hepatocellular carcinoma in NASH model. (2020) (3)
- Lipid Synthetic Transcription Factor SREBP-1a Activates p21 WAF1/CIP1 , a Universal Cyclin-Dependent (2005) (3)
- FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin (2021) (3)
- Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice. (2022) (3)
- [SREBP-1c and Elovl6 as Targets for Obesity-related Disorders]. (2015) (3)
- Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion (2020) (3)
- Association of eating three meals irregularly with changes in BMI and weight among young Japanese men and women: A 2-year follow-up (2016) (3)
- Serum lactate dehydrogenase level as a possible predictor of treatment preference in psoriasis. (2021) (3)
- CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2. (2021) (2)
- Sterol Regulatory Element-binding Proteins Activate Insulin Gene Promoter Directly and Indirectly through Synergy with BETA 2 / E 47 * (2005) (2)
- Microarray Analyses of SREBP-1 Target Genes (2004) (2)
- Cyclin-dependent Kinase Inhibitor, p21 WAF1/CIP1 , Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to (2008) (2)
- Severity of hypertension as a predictor of initiation of dialysis among study participants with and without diabetes mellitus (2020) (2)
- CYCLIN-DEPENDENT KINASE INHIBITOR, p21 WAF1/CIP1 , IS INVOLVED IN ADIPOCYTE DIFFERENTIATION AND HYPERTROPHY, LINKING TO OBESITY AND INSULIN RESISTANCE. (2008) (2)
- Acetyl-coenzyme A synthetase is a new lipogenic enzyme controlled by sterol regulatory element-binding proteins and influenced by diabetes (2001) (2)
- Effect of macrophage colony-stimulating factor on the development of diabetes mellitus in BB rats. (1993) (2)
- Utility of nonblood-based risk assessment for predicting type 2 diabetes mellitus: A meta-analysis. (2016) (2)
- Meta‐analytic research on the relationship between cumulative risk alleles and risk of type 2 diabetes mellitus (2016) (2)
- Characterization of monoclonal anti-rabbit apolipoprotein E antibodies and chemical composition of lipoproteins separated by anti-apolipoprotein E immuno-affinity chromatography. (1991) (2)
- CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions (2021) (2)
- The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis (2021) (2)
- High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways. (2021) (2)
- Guidelines on the Clinical Evaluation of Medicinal Products for Treatment of Dyslipidemia (2020) (2)
- Effect of Monocyte Colony‐Stimulating Factor (M‐CSF) on Lipoprotein Metabolism (1990) (1)
- Protocol for rapid manipulation of mitochondrial morphology in living cells using inducible counter mitochondrial morphology (iCMM) (2021) (1)
- SREBPs: Activators of cholesterol and monounsaturated fatty acid synthesis (1999) (1)
- Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711 (2021) (1)
- New liver–β‐cell axis that controls insulin secretory capacity (2014) (1)
- Transgenic mice expressing an intestine-specific secretory protein, IBCAP, demonstrates pancreatic beta cell augmenting activity (2010) (1)
- Erratum: Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice (2013) (1)
- 2P-0618 Fenofibrate therapy improves postprandial responses to fat and malondialdehyde-modified low-density lipoprotein (MDA-LDL) levels in diabetic and non-diabetic patients with hypertriglyceridemia (2003) (1)
- Exploratory analysis using machine learning of predictive factors for falls in type 2 diabetes (2022) (1)
- A neonatal case of apolipoprotein C-II deficiency (1989) (1)
- Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids (2021) (1)
- Use of high-normal levels of hemoglobin A 1 C and fasting plasma glucose for diabetes screening and prediction-A meta-analysis Running title : A 1 C / FPG for diabetes screening and prediction (2013) (1)
- Cholesterol‐Free Diet in Heterozygous Familial Hypercholesterolemia (1990) (1)
- Correction to: Different impacts of metabolic profiles on future risk of cardiovascular disease between diabetes with and without established cardiovascular disease: the Japan diabetes complication and its prevention prospective study 7 (JDCP study 7) (2021) (1)
- Liver–Intestine CREBH Regulates Systemic Glucose and Lipid Metabolism (2018) (1)
- New balance capability index as a screening tool for mild cognitive impairment (2021) (1)
- Quantitative assessment of genetic testing for type 2 diabetes mellitus based on findings of genome-wide association studies. (2016) (1)
- Treatment of diabetes mellitus has borne much fruit in the prevention of cardiovascular disease (2022) (1)
- Enhanced synthesis and secretion of apolipoprotein E from sciatic nerves of streptozotocin-induced diabetic rats after injury. (1988) (1)
- Plasma chloride concentration as a new diagnostic indicator of insulin insufficiency. (2005) (1)
- Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation (2018) (1)
- 53 Involvement in the Pathogenesis of Fatty Liver Disease * (2004) (1)
- ER ligands ameliorate fatty liver through a non-classical ER / LXR pathway (2013) (1)
- Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling (2021) (1)
- Erratum to: HbA1c variability and the development of microalbuminuria in type 2 diabetes: Tsukuba Kawai Diabetes Registry 2 (2013) (1)
- [Transcription factor, TFE3 improves metabolic syndrome]. (2011) (0)
- Effects of Overexpressed Apolipoprotein E on Plasma Lipoprotein Metabolism in Transgen ic Mice (1992) (0)
- ALS-Causing Protein TDP-43 Impairs SREBP2 Cholesterol Regulation (2021) (0)
- Abstract 148: Sterol Regulatory Element-Binding Protein-1 Is Involved in the Development of Angiotensin II-Induced Cardiac Fibrosis (2012) (0)
- [Roles of energy metabolism transcription factors]. (2006) (0)
- L-Asparaginase-Induced Continuous Hyperglycemia With Type 1 Diabetes-Related Antibodies and HLA Genotypes: A Case Study (2022) (0)
- p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet (2022) (0)
- 1P-0130 Genetic analysis of the spontaneously hypertensive rats (SHR), an animal model of metabolic syndrome (2003) (0)
- 005 Respiratory activity in psoriatic circulating T cells predicts the efficacy of apremilast (2020) (0)
- Reply (2004) (0)
- EPA prevents palmitate-induced β-cell lipotoxicity by suppression of SREBP-1c (2007) (0)
- Hepatocyte or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced NAFLD. (2022) (0)
- APPLICATION OF LASER BEANS IN HEPATECTOMY (1985) (0)
- Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques (2022) (0)
- Role of Elovl6 in brown and beige adipose tissue during [beta]3-adrenergic receptor activation (2017) (0)
- Abstract 1555: Parasympathetic Response of the Heart is Attenuated in Sterol Response Element Binding Protein Knockout Mice (2006) (0)
- Transcription factors that regulate insulin sensitivity in the liver and metabolic syndrome (2006) (0)
- Transcriptional Regulation of Lipid Metabolism in vivo by SREBP Family (2000) (0)
- Characterization of Low Density Lipoprotein Receptors in Normal and Watanabe Heritable Hyperlipidemic Rabbits (1990) (0)
- [Gene therapy for hyperlipoproteinemia]. (2001) (0)
- Diet and Hyperlipidemia in Transgenic Mouse: ―トランスジェニック動物より― (1996) (0)
- Contents, Supplement 1, 1990 (1990) (0)
- Abstract 12521: Intracellular Fatty Acid Balance Regulated by Elovl6 Plays a Notable Phenotypic Response of Vascular Smooth Muscle Cells via AMPK-KLF4-Dependent Signaling (2016) (0)
- Regulation of low density lipoprotein receptor activity in Chinese hamster ovary cells transfected with the c‐fms gene (1994) (0)
- [Analysis on lipid metabolism and atherogenesis by transgenic technology]. (1994) (0)
- A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction (2022) (0)
- CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis (2022) (0)
- Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization (2015) (0)
- The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation (2023) (0)
- [Surgical treatment of an aneurysm of the thoracic aorta and operative nursing care]. (1984) (0)
- Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation (2022) (0)
- A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation (2022) (0)
- Computational design and molecular mechanism in oligomerization of C‐terminal binding protein 2 (2018) (0)
- Role of ApoE in the Metabolism of Triglyceride-rich Lipoproteins: Transgenic Mice Overexpressing Apolipoprotein E: ―アポEを過剰発現するトランスジェニックマウス― (1995) (0)
- Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis. (2023) (0)
- Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes (2020) (0)
- Takotsubo cardiomyopathy with left ventricle thrombus caused by subacute thyroiditis (2023) (0)
- Macrophages rely on extracellular serine to suppress aberrant cytokine production (2021) (0)
- Roles of Apolipoprotein E in Lipoprotein Metabolism and Atherosclerosis: Insights From Transgenic Mice (1996) (0)
- Different impacts of metabolic profiles on future risk of cardiovascular disease between diabetes with and without established cardiovascular disease: the Japan diabetes complication and its prevention prospective study 7 (JDCP study 7) (2021) (0)
- Hitoshi Shimano ApoAII Controversy Still in Rabbit ? (2009) (0)
- [Functions of transcription factors involved in lipid metabolism]. (2007) (0)
- dimerizes with other bHLH proteins, cooperatively enhanced the Sox9-dependent transcription in luciferase reporter assays. Coactivator p300 synergistically increased the activity of Sox9-regulated reporter gene, which contains promoter and enhancer regions of Col2a1, in the presence of Scx and E47. (2011) (0)
- Abstract 15165: Sterol Regulatory Element-Binding Protein-1 Participates in the Development of Cardiac Injury Partly via Chronic Inflammation (2011) (0)
- [Ageing and metabolic syndrome]. (2008) (0)
- Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency (2021) (0)
- Role of Elovl6 in the thermogenic action of brown and beige adipocyte during [beta]3-adrenergic receptor activation (2018) (0)
- Elucidating the Efficacy of Clinical Drugs Using FMO (2021) (0)
- Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism (2019) (0)
- Title Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (2018) (0)
- SREBPs activate insulin gene promoter directly and indirectly through synergy with BETA2/E47. (2005) (0)
- Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia (2023) (0)
- Abstract 13688: Long Chain Fatty Acid Composition Modulated by Elovl6 Plays a Critical Role in Vascular Smooth Muscle Cell Proliferation and Neointimal Formation (2014) (0)
- [Diverse physiological and pharmacological functions of fatty acids]. (2008) (0)
- FoxO-KlLF5 Pathway Switches the Flow of Macronutrients Under the Control of Insulin (2021) (0)
- 1P-0308 Long-term exercise improves postprandial response to fat in healthy elderly subjects (2003) (0)
- Disruption of the LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia and atherosclerosis resulting from the production of lipid-rich VLDL (1999) (0)
- Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMM (2020) (0)
- ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice. (2022) (0)
- A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges (2017) (0)
- [Quality aspects of lipid accumulation in insulin resistance--a lesson from long fatty acid elongase, Elovl-6]. (2008) (0)
- Kobe University Repository : Kernel タイトル Tit le Apolipoprotein E Prevents the Progression of Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits 著者 (2018) (0)
- National Cholesterol Awareness Month Article Macrophage Elovl 6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice (2011) (0)
- In vivo Functions of SREBPs (2000) (0)
- [Dysfunction of transcription factors in energy metabolism]. (2007) (0)
- Title MicroRNA-33 regulates sterol regulatory element-bindingprotein 1 expression in mice (2016) (0)
- Dietary intake and physical activity in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention prospective study (JDCP study 8) (2022) (0)
- Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients (2018) (0)
- Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells (2022) (0)
- [Role of Fatty Acid Elongase Elovl6 in the Regulation of Fatty Acid Quality and Lifestyle-related Diseases]. (2022) (0)
- The Role Of Elovl6 In Pulmonary Fibrosis (2012) (0)
- Effect of Niceritrol(Perycit(R))on Serum Levels of Lipopmtein(a): Assessing the Effect of Gradually Increased Dosages (2011) (0)
- CREBH regulates ChREBP-mediated hepatic fructose metabolism (2019) (0)
- 1910-P: SOCS3 Deficiency on a High-Fat Diet Accelerates Systemic Inflammation and Results in Lethal Myeloid Hematopoiesis without Obesity and Adiposity (2019) (0)
- [Pathophysiology of metabolic syndrome]. (2004) (0)
- Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood (2018) (0)
- Role of apo E on the surface of hepatocytes in chylomicron remnant catabolism (1994) (0)
- 2WS10-3 Transcriptional regulation of energy metabolism and atherosclerosis (2003) (0)
- [Current state of transcriptome analysis in lipid metabolism]. (2001) (0)
- [Mechanism involved and evaluation of lipid metabolism abnormalities and arteriosclerosis. Analysis by using experimental animals]. (2001) (0)
- 1 Liver – intestine CREBH regulates systemic glucose 2 and lipid metabolism 3 (2018) (0)
- Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial (2022) (0)
- [Oral hypoglycemic agents, present and future]. (2006) (0)
- Structure of PPARalpha-LBD/pemafibrate/SRC1 peptide (2020) (0)
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What Schools Are Affiliated With Hitoshi Shimano?
Hitoshi Shimano is affiliated with the following schools:
