Holger Stark

Q: What Schools Are Affiliated With Holger Stark

Holger Stark is affiliated with the following schools: Goethe University Frankfurt, Heinrich Heine University Düsseldorf, University of Regensburg, Free University of Berlin, University of Hamburg, Technical University of Berlin

Holger Stark's AcademicInfluence.com Rankings

Holger Stark

Physics

#7575

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#9617

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physics Degrees

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Physics

Holger Stark's Degrees

Bachelors Physics University of Hamburg

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Holger Stark's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Expression and modulation of CD44 variant isoforms in humans (1994) (471)
High constitutive activity of native H3 receptors regulates histamine neurons in brain (2000) (464)
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors (2015) (375)
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function (2003) (368)
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. (1998) (237)
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds. (2018) (236)
Histamine H4 Receptor Stimulation Suppresses IL-12p70 Production and Mediates Chemotaxis in Human Monocyte-Derived Dendritic Cells 1 (2005) (226)
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H3 Receptor: Preclinical Pharmacology (2007) (215)
The histamine H4 receptor is functionally expressed on T(H)2 cells. (2009) (205)
Identification of Dopamine D1–D3 Receptor Heteromers (2008) (203)
Histamine H3 receptor antagonists go to clinics. (2008) (184)
DOGS: Reaction-Driven de novo Design of Bioactive Compounds (2012) (179)
Effects of intracerebroventricularly infused histamine and selective H1, H2 and H3 agonists on food and water intake and urine flow in Wistar rats (1998) (161)
Distinct pharmacology of rat and human histamine H3 receptors: role of two amino acids in the third transmembrane domain (2000) (150)
Protean agonism at histamine H3 receptors in vitro and in vivo (2003) (145)
Histamine H3 and H4 receptors as novel drug targets (2009) (144)
Pharmacological Analysis Demonstrates Dramatic Alteration of D1 Dopamine Receptor Neuronal Distribution in the Rat Analog of l-DOPA-Induced Dyskinesia (2009) (137)
Histamine H4 receptor antagonism reduces hapten‐induced scratching behaviour but not inflammation (2009) (132)
[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors. (1994) (131)
Histamine H1, H3 and H4 receptors are involved in pruritus (2011) (129)
Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors. (2005) (127)
Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. (2007) (123)
Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor. (2008) (112)
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases (2016) (110)
Dopamine D3 Receptor Ligands Block Nicotine-Induced Conditioned Place Preferences through a Mechanism that does not Involve Discriminative-Stimulus or Antidepressant-Like Effects (2005) (103)
Histamine H4 receptors modulate dendritic cell migration through skin – immunomodulatory role of histamine (2008) (100)
Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. (2001) (98)
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies (2019) (92)
N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands (2003) (91)
Development of Novel 1,2,3,4‐Tetrahydroisoquinoline Derivatives and Closely Related Compounds as Potent and Selective Dopamine D3 Receptor Ligands (2004) (81)
Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease (2013) (78)
Derivatives of β-casomorphins with high analgesic potency (1984) (78)
CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues (1994) (77)
Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug. (1997) (77)
Improvement by FUB 181, a novel histamine H3-receptor antagonist, of learning and memory in the elevated plus-maze test in mice (1998) (71)
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases. (2017) (70)
Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function (2009) (68)
Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening (2007) (66)
Cherry-picked ligands at histamine receptor subtypes (2016) (65)
2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. (2009) (65)
DEVELOPMENTS OF HISTAMINE H3-RECEPTOR ANTAGONISTS (1996) (65)
Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists. (2004) (64)
Recent advances in histamine H3/H4 receptor ligands (2003) (64)
Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands. (2011) (61)
Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. (2002) (61)
Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283 (2014) (61)
Microdialysate analysis of monoamine neurotransmitters--a versatile and sensitive LC-MS/MS method. (2013) (60)
Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone (2014) (59)
Dopamine D3 Receptor Ligands with Antagonist Properties (2002) (58)
Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases (2016) (56)
[125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor. (1996) (55)
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. (1996) (55)
Predicting Compound Selectivity by Self‐Organizing Maps: Cross‐Activities of Metabotropic Glutamate Receptor Antagonists (2006) (54)
Polypharmacology of dopamine receptor ligands (2016) (52)
Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties. (2014) (50)
The histamine H3 receptor and its ligands. (2001) (50)
Different antagonist binding properties of human and rat histamine H3 receptors. (2001) (48)
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. (2009) (48)
Histamine receptor subtypes: a century of rational drug design. (2012) (48)
Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation (2015) (46)
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase. (2012) (45)
Synthesis, X-ray crystallography, and pharmacokinetics of novel azomethine prodrugs of (R)-alpha-methylhistamine: highly potent and selective histamine H3 receptor agonists. (1995) (44)
Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands. (2014) (44)
Lack of preventing effect of systemically and topically administered histamine H1 or H4 receptor antagonists in a dog model of acute atopic dermatitis (2011) (43)
Histamine H3 receptor antagonists/inverse agonists: Where do they go? (2019) (43)
Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists. (2002) (42)
Brain-derived neurotrophic factor and the plasticity of the mesolimbic dopamine pathway. (2004) (42)
The histamine H₄ receptor: targeting inflammatory disorders. (2011) (42)
Traumatic brain injury results in mast cell increase and changes in regulation of central histamine receptors (2005) (42)
In vivo conversion of vasopressin after microinjection into limbic brain areas of rats (1989) (41)
Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug. (2000) (41)
Ceramide synthesis regulates T cell activity and GVHD development. (2017) (40)
Inhibitors of specific ceramide synthases. (2012) (40)
Multiple Targeting Approaches on Histamine H3 Receptor Antagonists (2016) (40)
Highly Potent Fluorescence‐Tagged Nonimidazole Histamine H3 Receptor Ligands (2007) (40)
IDENTIFICATION OF DOPAMINE D 1 -D 3 RECEPTOR HETEROMERS: INDICATIONS FOR A ROLE OF SYNERGISTIC D 1 -D 3 RECEPTOR INTERACTIONS IN THE STRIATUM* (2008) (40)
Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H4 Receptor (2009) (39)
Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists. (2006) (37)
Refined Docking as a Valuable Tool for Lead Optimization: Application to Histamine H3 Receptor Antagonists (2008) (37)
The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammation in sodium valproate induced autism in mice. (2019) (36)
Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. (2000) (34)
Increase in aldose reductase mRNA in dog lens epithelial cells under hypertonic conditions. (1990) (34)
Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists (2014) (32)
Influence of the novel histamine H3 receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice (2013) (32)
Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse (2018) (31)
Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor. (2003) (31)
Kojic acid derivatives as histamine H(3) receptor ligands. (2010) (31)
Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson's disease. (2018) (31)
Exploring the chemical space of multitarget ligands using aligned self-organizing maps. (2013) (30)
Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist. (2001) (30)
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. (2003) (29)
Ciproxifan and chemically related compounds are highly potent and selective histamine H3-receptor antagonists (1998) (29)
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents. (2016) (29)
Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. (2014) (29)
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors. (2011) (29)
Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds. (2003) (29)
From Molecular Shape to Potent Bioactive Agents II: Fragment‐Based de novo Design (2009) (28)
Ca2+-sensing Receptor Cleavage by Calpain Partially Accounts for Altered Vascular Reactivity in Mice Fed a High-fat Diet (2013) (28)
From Virtual to Real Screening for D3 Dopamine Receptor Ligands (2005) (28)
Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. (2013) (28)
Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H4 Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts (2013) (27)
Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies (2018) (27)
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor (2016) (27)
Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor (2018) (27)
Novel Chalcone-Based Fluorescent Human Histamine H3 Receptor Ligands as Pharmacological Tools (2012) (27)
Fluorinated non-imidazole histamine H3 receptor antagonists. (2009) (27)
Procognitive Properties of Drugs with Single and Multitargeting H3 Receptor Antagonist Activities (2014) (27)
Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents. (2006) (27)
Alpha 6 integrin distribution in human embryonic and adult tissues (2004) (26)
Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity. (1999) (26)
Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinities. (2006) (26)
Profiling of histamine H4 receptor agonists in native human monocytes (2013) (26)
Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B (2017) (25)
Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action. (2015) (25)
Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats (2016) (25)
Scaffold variations in amine warhead of histamine H₃ receptor antagonists. (2013) (24)
(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands. (2015) (24)
Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice (2014) (24)
Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. (2007) (23)
New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. (2000) (23)
Development of FUB 181, a Selective Histamine H3‐Receptor Antagonist of High Oral in Vivo Potency with 4‐(?gv‐(Arylalkyloxy)alkyl)‐1H‐imidazole Structure (1998) (23)
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism. (2014) (22)
From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties (2013) (22)
Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand. (2013) (22)
Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo. (2016) (22)
Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands. (2019) (22)
Cognitive Improvements in Children with Prader-Willi Syndrome Following Pitolisant Treatment-Patient Reports. (2019) (22)
Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands. (2018) (21)
Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat (2004) (21)
Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats (2018) (21)
Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists (2016) (21)
Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists (2002) (21)
N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. (2011) (21)
Histamine H3 receptor ligands by hybrid virtual screening, docking, molecular dynamics simulations, and investigation of their biological effects (2019) (21)
Prevention of Bleomycin-Induced Lung Inflammation and Fibrosis in Mice by Naproxen and JNJ7777120 Treatment (2014) (21)
First metal-containing histamine H3 receptor ligands. (2010) (21)
Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism (2020) (20)
Brief report: first identification of H₄ histamine receptor in healthy salivary glands and in focal sialadenitis in Sjögren's syndrome. (2012) (20)
Iododestannylation : An improved synthesis of [125I]iodoproxyfan, a specific radioligand of the histamine H3 receptor (1997) (20)
Introducing Students to NMR Methods Using Low-Field 1H NMR Spectroscopy to Determine the Structure and the Identity of Natural Amino Acids (2017) (20)
Cellular analysis of the histamine H4 receptor in human myeloid cells. (2016) (20)
Experimental models for discovery of novel anticonvulsant drugs: Focus on Pentylenetetrazole-induced seizures and associated memory deficits. (2020) (20)
Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. (1999) (19)
FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase (2015) (19)
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments (2016) (19)
Quantitative Analysis of Multicomponent Mixtures of Over-the-Counter Pain Killer Drugs by Low-Field NMR Spectroscopy (2017) (19)
Stimulation of the histamine 4 receptor upregulates thymic stromal lymphopoietin (TSLP) in human and murine keratinocytes. (2016) (19)
Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism (2017) (19)
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors. (2012) (19)
From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation (2017) (19)
The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice (2020) (19)
Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation. (2018) (19)
4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity. (1998) (19)
Histamine H4 Receptor: A Novel Drug Target for Immunoregulation and Inflammation (2013) (19)
Polymorphisms and genetic linkage of histamine receptors. (2013) (18)
Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation. (2020) (18)
Role of histamine H4 receptor ligands in bleomycin-induced pulmonary fibrosis. (2016) (18)
A search for functional histamine H4 receptors in the human, guinea pig and mouse brain (2014) (18)
Acidic elements in histamine H(3) receptor antagonists. (2010) (18)
Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. (2002) (18)
Predicting targets of compounds against neurological diseases using cheminformatic methodology (2015) (18)
Teil 2: Therapiekonzepte und neue Rezeptorliganden (2000) (17)
Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists. (2004) (17)
Acylated and alkylated histamine derivatives as new histamine H3-receptor antagonists (1994) (17)
Development of novel aminothiazole-comprising 5-LO inhibitors. (2016) (17)
Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists. (2002) (17)
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis (2019) (17)
Histamine Downregulates the Th1-Associated Chemokine IP-10 in Monocytes and Myeloid Dendritic Cells (2013) (17)
Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors (2015) (17)
The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor (2018) (17)
Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine H3R ligands. (2018) (17)
Histamine H3R Antagonists: From Scaffold Hopping to Clinical Candidates (2016) (17)
Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound. (2014) (17)
Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: evidence for H3 receptor heterogeneity? (1996) (17)
The histamine H receptor as a new target for treatment of canine inflammatory skin diseases. (2009) (16)
Azines and Diazines as Potential Histamine H3‐Receptor Antagonists (1995) (16)
(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors. (2000) (16)
The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages (2018) (16)
Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. (2009) (16)
Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. (2015) (16)
Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands (2001) (16)
Drug Discovery: From Hits to Clinical Candidates (2008) (16)
Next Steps in Advancing Publication (2015) (16)
Histamine H4 receptor in oral lichen planus. (2015) (16)
The histamine H3-receptor: pharmacology, roles and clinical implications studied with agonists. (1991) (15)
Diphenylmethyl ethers: synthesis and histamine H3-receptor antagonist in vitro and in vivo activity (1996) (15)
Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties. (2015) (15)
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. (2005) (15)
Unsymmetrically substituted guanidines as potent histamine H3-receptor antagonists (1994) (15)
Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. (2008) (15)
Molecular pharmacological profile of a novel thiazolinone‐based direct and selective 5‐lipoxygenase inhibitor (2012) (15)
Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands. (2009) (15)
Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands (2019) (15)
Application of genomics to drug design: the example of the histamine H3 receptor (2001) (15)
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch (2021) (14)
Struktur, Funktion und potentielle therapeutische Bedeutung von NMDA-Rezeptoren (2000) (14)
An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. (2017) (14)
General construction pattern of histamine H3-receptor antagonists: change of a paradigm. (1998) (14)
Modulation of acid secretion from enriched guinea pig parietal cells by opioid receptors. (1983) (14)
The Histamine H4 Receptor Regulates Chemokine Production in Human Natural Killer Cells (2015) (14)
Histamine H3‐receptor antagonists inhibit gastroprotection by (R)‐α‐methylhistamine in the rat (2000) (13)
Azole derivatives as histamine H3 receptor antagonists, part I: thiazol-2-yl ethers. (2010) (13)
Binding of histamine H3‐receptor antagonists to hematopoietic progenitor cells (1997) (13)
Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus (2019) (13)
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands. (2017) (13)
In Silico Characterization of Ligand Binding Modes in the Human Histamine H4 Receptor and their Impact on Receptor Activation (2010) (13)
Fluorescent Human EP3 Receptor Antagonists. (2012) (13)
Role of Histamine H3 Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma (2019) (12)
Novel Histamine H3‐Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure‐Activity Relationships (1996) (12)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N‐Methyltransferase: ω‐Piperidinoalkanamine Derivatives (2004) (12)
Synthesis and evaluation of novel ligands for the histamine H₄ receptor based on a pyrrolo[2,3-d]pyrimidine scaffold. (2013) (12)
Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands. (2017) (12)
Parallel synthesis and dopamine D3/D2 receptor screening of novel {4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}carboxamides. (2005) (12)
Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands. (2019) (12)
Computer‐Assisted Analysis of Histamine H2− and H3‐Receptor Agonists (1995) (12)
Turning from monogamy to strategic promiscuity. (2004) (12)
Pharmacophore modeling, drug design and virtual screening on multi-targeting procognitive agents approaching histaminergic pathways (2015) (12)
Identification of histamine receptor subtypes in skeletal myogenesis (2014) (12)
Histamine H3 Receptors Are Involved in the Protective Effect of Ghrelin against HCl-Induced Gastric Damage in Rats (2010) (12)
Histamine H4 receptor ligands (2013) (12)
Heterocyclic congeners of PD 128,907 with a partially hydrogenated benzomorpholine moiety as potential dopamine D3-receptor ligands (1999) (12)
Efficient chromatography-free synthesis of the oxy-analogue of fingolimod (2010) (11)
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands. (2003) (11)
Studies on molecular properties prediction and histamine H3 receptor affinities of novel ligands with uracil-based motifs. (2014) (11)
Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands (2014) (11)
GPCR Targeted Library Design: Novel Dopamine D3 Receptor Ligands (2007) (11)
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs (2020) (10)
Ligand binding kinetics at histamine H3 receptors by fluorescence‐polarization with real‐time monitoring (2019) (10)
Rasagiline derivatives combined with histamine H3 receptor properties. (2019) (10)
The Synthesis of 1,3,5‐triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter (2016) (10)
BF2.649, A NON-IMIDAZOLE INVERSE AGONIST/ANTAGONIST AT THE HUMAN HISTAMINE H3 RECEPTOR: PRECLINICAL PHARMACOLOGY (2006) (10)
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. (2015) (10)
Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-α-methylhistamine (2001) (10)
[Occurrence of CD44 and its isoforms under orthological and pathological conditions]. (1993) (10)
Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness. (2014) (10)
The Multi-Targeting Ligand ST-2223 with Histamine H3 Receptor and Dopamine D2/D3 Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and Brain Oxidative Stress in Mice (2021) (10)
Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats (2018) (10)
Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands. (2019) (10)
Dopamine D3 receptor agonists as pharmacological tools (2015) (10)
New potent histamine H3-receptor antagonists of the amide type (1995) (9)
Structure-activity relationships of novel azomethine prodrugs of the histamine H3-receptor agonist (R)-alpha-methylhistamine: from alkylaryl to substituted diaryl derivatives. (1996) (9)
Synthesis, X‐Ray Crystallography, and Pharmacokinetics of Novel Azomethine Prodrugs of (R)‐α‐Methylhistamine: Highly Potent and Selective Histamine H3 Receptor Agonists. (1996) (9)
Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models (2022) (9)
N‐(4‐(4‐(2‐Halogenophenyl)piperazin‐1‐yl)butyl) Substituted Cinnamoyl Amide Derivatives as Dopamine D2 and D3 Receptor Ligands (2007) (9)
Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives. (2018) (9)
In silico and in vitro studies of two non‐imidazole multiple targeting agents at histamine H3 receptors and cholinesterase enzymes (2020) (9)
Radiosynthesis and biodistribution of 123I-labeled antagonists of the histamine H3 receptor as potential SPECT ligands. (1999) (9)
4-(ω-(Alkyloxy)alkyl)-1H-imidazole Derivatives as Histamine H3 Receptor Antagonists/Agonists (2004) (9)
Monocyte-Derived Dendritic Cells Mediates Chemotaxis in Human Suppresses IL-12 p 70 Production and Histamine H 4 Receptor Stimulation (2005) (9)
Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis (2021) (9)
Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation. (2012) (8)
The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions. (2021) (8)
4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition. (2019) (8)
Model of a specific human histamine H3 receptor (hH3R) binding pocket suitable for virtual drug design (2005) (8)
Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis (2020) (8)
Characterization of the molecular mechanism of 5‐lipoxygenase inhibition by 2‐aminothiazoles (2017) (8)
Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors (2020) (8)
Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties (2010) (8)
Overdose of the histamine H3 inverse agonist pitolisant increases thermal pain thresholds (2012) (8)
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent. (2020) (8)
Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. (2000) (7)
Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands. (2017) (7)
Lead identification and optimization of diaminopyrimidines as histamine H4 receptor ligands (2010) (7)
Demonstrating Ligandability of the LC3A and LC3B Adapter Interface. (2021) (7)
Novel histamine H3 receptor antagonists: affinities in an H3 receptor binding assay and potencies in two functional H3 receptor models. (1994) (7)
HPV Vaccination: Prevention of Cervical Cancer in Serbia and in Europe (2018) (7)
Activation of histamine H3 receptor decreased cytoplasmic Ca(2+) imaging during electrical stimulation in the skeletal myotubes. (2015) (7)
Activation of histamine H4 receptor inhibits TNFα/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells (2014) (7)
Separation of chiral 4-substituted imidazole derivatives by cyclodextrin-modified capillary electrophoresis. (2001) (7)
Derivatives of beta-casomorphins with high analgesic potency. (1984) (7)
Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. (2004) (7)
Medicinal chemistry of histamine H3 receptor agonists (1998) (7)
Novel meriolin derivatives as rapid apoptosis inducers. (2019) (7)
Improving selectivity of dopamine D3 receptor ligands. (2016) (7)
Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. (2010) (6)
Hilft das zahnmedizinische Bonussystem den stationär Pflegebedürftigen? (2011) (6)
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties (2021) (6)
Low Field NMR Determination of pKa Values for Hydrophilic Drugs for Students in Medicinal Chemistry (2017) (6)
Synthesis of novel dansyl-labeled Celecoxib derivatives (2013) (6)
Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors. (2021) (6)
Convenient Procedures for Synthesis of Ciproxifan, a Histamine H3‐Receptor Antagonist (2000) (6)
Radiosynthesis and biodistribution of two potential antagonists of cerebral histamine H3 receptors for PET studies: [18F]FUB 272 and [11C]UCL 1829 (1998) (6)
Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands (2017) (6)
Piperazine modification in 2,4,6-triaminopyrimidine derivatives as histamine H4 receptor ligands. (2013) (6)
Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H3 receptor. (2019) (6)
Unique immunomodulatory effects of azelastine on dendritic cells in vitro (2014) (6)
Development of FUB 181, a Selective Histamine H3-Receptor Antagonist of High Oral in vivo Potency with 4-(ω-(Arylalkyloxy)alkyl)-1H-imidazole Structure. (1998) (6)
Histamine H(3)-receptor antagonists inhibit gastroprotection by (R)-alpha-methylhistamine in the rat. (2000) (6)
Histamine Receptors and Inflammatory Cells (2013) (6)
Wiederaufnahme‐Hemmung an der Präsynapse als Wirkprinzip: Medizinische Chemie moderner Antidepressiva — Targets und Arzneistoffe (2004) (5)
Papierstruktur in z-Richtung (2003) (5)
Medizinische Chemie von Histamin‐H2‐Rezeptorantagonisten: Klassische Wirkstoffentwicklung (2007) (5)
Piperidine-containing histamine H3-receptor antagonists of the carbamate series: variation of the spacer length. (2001) (5)
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease. (2021) (5)
Metabolism of beta-casomorphin and its derivatives in rat brain and liver homogenates. (1987) (5)
New Potent Azomethine Prodrugs of the Histamine H3‐Receptor Agonist (R)‐α‐Methylhistamine Containing a Heteroarylphenyl Partial Structure (1996) (5)
Deproceptin, Tyr-Pro-Phe-D-Pro-NH2, another casomorphin with remarkable analgesic action. (1982) (5)
Profiling of LINS01 compounds at human dopamine D2 and D3 receptors (2019) (5)
SQUIRRELnovo: de novo design of a PPARα agonist by bioisosteric replacement (2009) (5)
N-substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins. (2020) (5)
Gastroprotective activity of the novel histamine H3-receptor agonist FUB 407 (2001) (5)
Staatsfeind WikiLeaks : wie eine Gruppe von Netzaktivisten die mächtigsten Nationen der Welt herausfordert (2011) (4)
Hemmstoffe von Beta‐Adrenozeptoren: Gemeinsamkeiten und Unterschiede (2004) (4)
0771 Pitolisant Is A Safe And Effective Treatment For Children With Prader-willi Syndrome (pws) (2019) (4)
Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists (2021) (4)
Effects of Posterior-Pituitary-Lobe Peptides on the Maintenance of a Conditioned Avoidance Response in Rats (1978) (4)
Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK Pathway (2022) (4)
The chemical probe – scopes, limitations and challenges (2020) (4)
Discovery of Pitolisant, the First Marketed Histamine H3‐Receptor Inverse Agonist/Antagonist for Treating Narcolepsy* (2018) (4)
Autoreceptors and Heteroreceptors Evidenced by Histamine H3 Receptor Ligands (1991) (4)
Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae. (2019) (4)
Experimental autoimmune myocarditis in rats and therapeutic histamine H1 - H4 receptor inhibition. (2018) (4)
New Histamine H3-Receptor Ligands of the Proxifan Series: Imoproxifan and Other Selective Antagonists with High Oral in vivo Potency. (2000) (4)
Protonenpumpeninhibitoren: Strukturen, Mechanismen und Entwicklungen (2005) (3)
Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity. (2000) (3)
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis (2022) (3)
Constitutive activity of the recombinant and native histamine H3 receptor (2003) (3)
BOPPY-based novel fluorescent dopamine D2 and D3 receptor ligands. (2022) (3)
RELATIONSHIP BETWEEN LIPOPHILICITY AND BRAIN UPTAKE OF AZOMETHINE PRODRUGSOF A HISTAMINE H3-RECEPTOR AGONIST (1996) (3)
Medizinisch‐chemische Aspekte von Statinen: Wirkmechanismus von HMG‐CoA‐Reduktase‐Inhibitoren (2003) (3)
Novel Histamine H3-Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure-Activity Relationships. (1997) (3)
H1‐Antihistaminika: Entwicklungen, Strukturen und neue Tendenzen (2004) (3)
Synthesis and histamine H3-receptor agonist activity of mono- and dialkyl-substituted histamine derivatives† (1995) (3)
From Target to Lead Synthesis (2006) (3)
Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands (2021) (3)
Über die Schwingungsform des Steigbügels in Abhängigkeit von der Lautstärke (1977) (3)
The Search for Histamine H 4 Receptor Ligands with Anticancer Activity among Novel (Thio)urea Derivatives (2019) (3)
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate (2019) (3)
[Structure, function and potential therapeutic possibilities of NMDA receptors. 2. Therapy concepts and new receptor ligands]. (2000) (3)
[Medicinal chemistry of histamine H2 receptor antagonists]. (2007) (3)
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies (2019) (3)
Search for novel leads for histamine H3-receptor antagonists: oxygen-containing derivatives. (1997) (3)
Histamine H3-receptor activation inhibits acetylcholine release from the guinea pig myenteric plexus (1991) (3)
The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages (2018) (3)
Development of a binding site model for histamine H3-receptor agonists. (1998) (3)
Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson's Disease. (2021) (3)
Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease. (2022) (3)
Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. (2022) (3)
In vitro penetration of des-tyrosine1-D-phenylalanine3-β-casomorphin across the blood-brain barrier (1992) (3)
AGMO Inhibitor Reduces 3T3-L1 Adipogenesis (2021) (2)
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the influence of the additional ether functionality. (2002) (2)
Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands (2019) (2)
The role of ceramide synthases in pancreatic beta cell demise (2018) (2)
Chapter 6 Histamine in Atopic Disorders: Atopic Dermatitis and Pruritus (2013) (2)
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease (2023) (2)
New lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class. (2018) (2)
Medizinische Chemie der L‐Typ‐Calcium‐Kanalblocker: Dihydropyridine und Nicht‐Dihydropyridine (2005) (2)
Eosinophils adhesion assay as a tool for phenotypic drug screening - The pharmacology of 1,3,5 - Triazine and 1h-indole like derivatives against the human histamine H4 receptor. (2020) (2)
The Novel Pimavanserin Derivative ST-2300 with Histamine H3 Receptor Affinity Shows Reduced 5-HT2A Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice (2022) (2)
Tinnitus: Ich höre was, was Du nicht hörst (2010) (2)
Discovery of Potential, Dual-Active Histamine H3 Receptor Ligands with Combined Antioxidant Properties (2021) (2)
Histamine H₄ Receptor Antagonists: A New Approach for Tinnitus Treatment? (2015) (2)
Role of Histamine H 3 Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma (2019) (2)
Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (2)
Chapter 3 Histamine Metabolism (2013) (2)
Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome (2020) (2)
Corrigendum to “Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness” [Bioorg. Med. Chem. Lett. 24 (2014) 2236–2239] (2014) (2)
Degradation of beta-casomorphin in the rat brain in vivo. (1986) (2)
A solid phase parallel synthesis of diverse amides as dopamine D3 receptor ligands (2008) (2)
Metabolism of D-proline beta-casomorphin derivatives in the rat brain. (1988) (2)
Increase of paradoxical sleep (PS) by intraperitoneal injection of brain extract from PS-deprived rats (1987) (2)
Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the alkyl derivatives. (2005) (2)
Multipotente Liganden mit kombinierter Cholinesterase‐ und Monoaminooxidase‐Inhibition sowie Histamin‐H3R‐Antagonismus bei neurodegenerativen Erkrankungen (2017) (2)
[News of the old histamine. I. A widening of the receptor family]. (2003) (2)
Design of histamine H3-receptor agonists and antagonists (1994) (2)
Pharmacological aspects of cognitive impairment: past, present and future of drugs in dementia (2007) (2)
ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo (2021) (2)
Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands (2009) (1)
Convenient Procedures for Synthesis of Ciproxifan, a Histamine H3-Receptor Antagonist. (2000) (1)
A novel cell line from human eccrine sweat gland duct cells for investigating sweating physiology (2022) (1)
A solid phase parallel synthesis of diverse amides as dopamine D3 receptor ligands. (2008) (1)
Corrigendum to “Fluorinated non-imidazole histamine H3 receptor antagonists” [Bioorg. Med. Chem. Lett. 19 (2009) 2172] (2009) (1)
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease (2022) (1)
[News on the old histamine. II. Ion channels in Drosophila]. (2003) (1)
Application of genomics to drug design: the example of the histamine H 3 (2001) (1)
The histamine H 4 receptor story (2013) (1)
Neurotransmitters, Agonists, and Antagonists (2005) (1)
Novel histamine H 3 receptor antagonists : affinities in an H 3 receptor binding assay and potencies in two functional H 3 receptor models ' (2006) (1)
Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice (2018) (1)
Biphenylalkoxyamine Derivatives–Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity (2021) (1)
P84 novel potent histamine H3-receptor antagonists (1994) (1)
Chapter 8 Histamine in Cancer (2013) (1)
Chapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders (2013) (1)
Synthesis and Histamine H3‐Receptor Agonist Activity of Mono‐ and Dialkyl‐Substituted Histamine Derivatives. (1995) (1)
Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation. (2021) (1)
[Development, structures, and new trends. H1-antihistamines]. (2004) (1)
Targeting UGCG overcomes resistance to lysosomal autophagy inhibition. (2022) (1)
Novel pyrrolidinone derivative lacks claimed histamine H3 receptor stimulation in receptor binding and functional studies. (2020) (1)
Potent Partial Agonists for the Histamine H3 Receptor Lacking a Nitrogen Atom in the Side Chain (2002) (1)
Heterocyclic Congeners of PD 128,907 with a Partially Hydrogenated Benzomorpholine Moiety as Potential Dopamine D3-Receptor Ligands. (2010) (1)
Theoretical and pharmacological study of multitarget compounds against neurological diseases. (2014) (1)
Guided rational design with scaffold hopping leading to novel histamine H3 receptor ligands. (2021) (1)
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists. (2004) (1)
Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment. (2022) (1)
Substituted N-phenylcarbamates as histamine H3 receptor antagonists with improved in vivo potency. (2000) (1)
Evaluation of a polyclonal antibody against canine filaggrin in immunohistochemical studies in atopic and normal beagle dogs (2011) (1)
Diphenylmethyl Ethers: Synthesis and Histamine H3-Receptor Antagonist in vitro and in vivo Activity. (1996) (1)
Search for novel leads for histamine H3-receptor antagonists: amine derivatives. (1997) (1)
Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine. (2001) (1)
Influence of Histamine H1, H2, and H3 Agonists and Antagonists on IgE Mediated Histamine Release from Human Basophils (1991) (1)
Protein-Cross-Linking zur Aufklärung von komplexen Strukturen (2018) (1)
[Structure, function and potential therapeutic possibilites of NMDA receptors. 1. Architecture and modulation of receptors]. (2000) (1)
Neue Wirkstoffe zur GERD-Behandlung: Innovationen in der Pipeline (2005) (1)
Kryo-Elektronenmikroskopische Strukturuntersuchungen an 70S Ribosomen in funktionellen Zustaenden der Proteinbiosynthese (1996) (1)
Neues zum alten Histamin I. Ein weiteres Mitglied in der Rezeptorfamilie (2003) (1)
Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties (2022) (1)
Neues zum alten Histamin II. Ionenkanäle in Drosophila (2003) (1)
Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors (2022) (1)
Sleep in Prader-Willi mouse mutants: the effects of pitolisant (2019) (0)
P85 highly potent and selective histamine H3-receptor antagonists (1994) (0)
The discovery of potent non-imidazole H3-receptor histamine antagonists (2001) (0)
Chapter 9 Non Receptor-mediated Histamine Actions (2013) (0)
Über die Messung der Faserorientierung in einem Papierblatt mittels Laserstrahlung (1988) (0)
Non-imidazolalkylaminer as histamine H 3 receptor and the therapeutic uses thereof (1999) (0)
Another Piece Of Puzzle In Adjuvant Treatment Of Inflammatory Diseases With Natural Compounds (2017) (0)
New derivatives of imidazole antagonists and / or agonists of the H3 receptor of histamine, their preparation and their therapeutic applications (1995) (0)
Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice (2018) (0)
Radiosynthesis and biodistribution of 123I labeled antagonists as potential SPECT ligands for the histamine H3 receptor (1999) (0)
Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain (2004) (0)
H1-Histamines: Development, Structure and Novel Trends (2004) (0)
N-alkyl carbamates as potent and selective histamine H3- receptor antagonists (1996) (0)
[New drugs for GERD treatment]. (2005) (0)
Inside Cover: Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H4 Receptor (ChemMedChem 5/2009) (2009) (0)
Influence of the novel histamine H3 receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice (2013) (0)
[Mechanism of action of HMG-CoA reductase inhibitors. Medical-chemical aspects of statins]. (2003) (0)
Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor (2018) (0)
Structural Modifications of β-Casomorphin-5: Synthesis and Pharmacology (1983) (0)
[Antitussives and expectorants]. (2008) (0)
The Efficiency of HMG‐CoA‐Reductase Inhibitors: Medicinal—Chemical Aspects of Statines. (2004) (0)
Activation of histamine H4 receptor inhibits TNFα/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells (2014) (0)
Histamine h3 receptor agonists for therapeutic application, pharmaceutical preparations acting on h3-adrenergic receptor-agonist, un the method of its presentation (1991) (0)
Antitussiva und Expektorantien. Medizinisch‐chemische Aspekte (2008) (0)
261 Stimulation of the histamine 4 receptor increases the production of IL-5 in innate lymphoid cells (2016) (0)
Structure, Function and Potential Therapeutic Importance of NMDA-Receptors. Part 1. Architecture and Modulation of the Receptors (2000) (0)
Messung der Faserorientierung in einem Papierblatt mit Laserstrahlung (1988) (0)
Therapeutic use as histamine H3 receptor ligands of alkyl amines which do not contain imidazoles (1999) (0)
NOVEL OXAZOLO-OXAZOLE DERIVATIVES OF FINGOLIMOD INDUCE LYMPHOPENIA AND REDUCE SYMPTOMS OF EAE IN MICE (2018) (0)
Chemical Probes for Histamine Receptor Subtypes. (2021) (0)
21. Mainzer Allergie-Workshop (2009) (0)
[Liebe Kolleginnen und Kollegen]. (2019) (0)
New derivatives of imidazole, their preparation and their therapeutic applications. (1992) (0)
[GDNF inhibits the catecholaminergic neurone]. (2008) (0)
Data for: Novel meriolin derivatives as rapid apoptosis inducers (2019) (0)
Book Review: G Protein-Coupled Receptors as Drug Targets ndash; Analysis of Activation and Constitutive Activity. Edited by R. Seifert, T, Wieland (2006) (0)
W1955 Resveratrol Analogues with Potent Anticarcinogenic Properties (2008) (0)
Corrigendum to "Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands" [Eur. J. Med. Chem. 185 (2020) 111785]. (2020) (0)
Histamine Activates Human Eosinophils via H2R and H4R Predominantly in Atopic Dermatitis Patients (2022) (0)
Survey of New, Small-Molecule Isatin-Based Oxindole Hybrids as Multi-Targeted Drugs for the Treatment of Alzheimer’s Disease (2021) (0)
Lebenszykluskosten in der Abwasserentsorgung (2012) (0)
New imidazole derivatives, their preparation and therapeutic uses (1993) (0)
Cover Picture: From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties (ChemMedChem 6/2013) (2013) (0)
Analytical Problem-Solving Procedures for Undergraduates by 1 H NMR (2020) (0)
Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives (2023) (0)
Experimental Studies Indicate That ST-2223, the Antagonist of Histamine H3 and Dopamine D2/D3 Receptors, Restores Social Deficits and Neurotransmission Dysregulation in Mouse Model of Autism (2022) (0)
N‐(4‐(4‐(2‐Halogenophenyl)piperazin‐1‐yl)butyl) Substituted Cinnamoyl Amide Derivatives as Dopamine D2 and D3 Receptor Ligands. (2007) (0)
Cocain-Bindungsstelle am Dopamintransporter geklärt (2008) (0)
Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice (2022) (0)
Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect (2023) (0)
[Resumption-inhibition in presynaptic action: the medicinal]. (2004) (0)
Prüfvorrichtung und Prüfverfahren zur zerstörungsfreien Druckbehälterprüfung und Druckbehälterbewertungsverfahren (2012) (0)
Editorial: Impact and other Improvements (2006) (0)
Subject Index Vol. 86, 2010 (2010) (0)
Anti-inflammatory effects of new human histamine H3 receptor ligands with flavonoid structure on BV-2 neuroinflammation (2022) (0)
Partial agonists for the histamine H3 receptor with high in vivo activity (2001) (0)
Neues Buch: The Practice of Medicinal Chemistry. Von Camille G. Wermuth. (2005) (0)
Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors. (2022) (0)
Dual Targeting Ligands—Histamine H3 Receptor Ligands with Monoamine Oxidase B Inhibitory Activity—In Vitro and In Vivo Evaluation (2022) (0)
INCREASE IN CIRCUMFERENTIAL STRESS IN ARTERIAL WALL DUE TO LOSS OF FUNCTION OF ELASTIN (2001) (0)
Synthesis of 1,2,3-TriazoleElements in Histamine H3 Receptor Ligands (2011) (0)
[The medicinal chemistry of L-type calcium channel blockers]. (2005) (0)
Chapter 2 Histamine H4 Receptor Ligands (2013) (0)
Novel histamine h3 receptor antagonist and / or agonist imidazole derivatives, their preparation and their therapeutic applications (1995) (0)
Contents Vol. 86, 2010 (2010) (0)
Benzophenone Derivatives and Related Compounds as Potent Histamine H3‐Receptor Antagonists and Potential PET/SPECT Ligands. (2001) (0)
Substituted Purines as High-Affinity Histamine H3 Receptor Ligands (2022) (0)
Protein-Cross-Linking zur Aufklärung von komplexen Strukturen (2018) (0)
Chapter 1 The histamine H4 receptor story (2013) (0)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N-Methyltransferase: ω-Piperidinoalkanamine Derivatives. (2005) (0)
Prodrug developments on histamine H3-receptors agonists (1996) (0)
Kaffee gegen Morbus Parkinson (2006) (0)
Die Problematik der Alterungsbeständigkeit bei Holzstoffen (1990) (0)
Neue Laufradgeneration: Optimierung von Betriebssicherheit und Wirkungsgrad (2011) (0)
NOVEL AGONISTS FOR THE DOPAMINE D 3 RECEPTOR SUBTYPE WITH HIGH IN VIVO ACTIVITY (2012) (0)
New imidazole derivatives, their production and therapeutic use (1993) (0)
Designs that enrich lives. (2007) (0)
Benzhydryl ethers prossessing combined histamine H3/H1-receptor antagonist activity (1996) (0)
[Coffee against Parkinson disease?]. (2006) (0)
Piezoelektrischer aktor mit einer ummantelung aus einem verbundwerkstoff (2007) (0)
Komplexe Regulationen bei Dopamin-D2-Rezeptoren (2006) (0)
From Magic Bullet To Magic Pump Gun: Multi-targeting Drugs For Neurodegenerative Diseases (2017) (0)
Role of histamine H-4 receptor on wheal and flare reactions in dog skin and on canine mast cell function (2009) (0)
Renaissance der Chlorbleiche (1990) (0)
Book Review: Neurotransmitters and Neuromodulators: Handbook of Receptors and Biological Effects, By Oliver von Bohlen und Halbach and Rolf Dermitzel (2003) (0)
[Cocaine-binding site on the dopamine transporter clarified]. (2008) (0)
Book Review: Comprehensive Organic Functional Group Transformations II by Alan Katritzky and Richard Taylor (2005) (0)
Verbindung einer Welle mit einem Turbinenrad eines Abgasturboladers (2005) (0)
Design of potent non-imidazole histamine H3-receptor antagonists (2003) (0)
[The neuroprotective B2 strengthens the aggregation of unfolded protein in Huntington chorea and Parkinson disease]. (2006) (0)
Histamine H3 Receptor Antagonists for Narcolepsy and (Un) Related Diseases (2018) (0)
Neuroprotektives B2 verstärkt die Ablagerung fehlgefalteter Proteine bei C. Huntington und M. Parkinson (2006) (0)
Honorary membership of the European Histamine Research Society (EHRS) (2007) (0)
SIRT1-unabhängige Antitumorwirkungen neuer Resveratrol-Analoga in Kolonkarzinomzellen (2010) (0)
Aryloxy- (oder Arylthio)alkylamine ohne Imidazolring als Histamin-H3-Antagonisten und deren therapeutische Anwendung (1998) (0)
1-(3-{4-[(2,4-Dinitroanilino)methyl]phenoxy}propyl)piperidinium chloride (2007) (0)
Separator für Brennstoffzellen mit Abstützung für eine MEA (2002) (0)
Histamine receptors in GtoPdb v.2021.3 (2021) (0)
Pharmakotherapie: Neuropathischer Schmerz: Klassifizierungen und Behandlungsoptionen (2004) (0)
[Complex regulation of dopamine d2 receptors]. (2006) (0)
Retinazellen gegen Morbus Parkinson (2006) (0)
OLHA (N α -oleoylhistamine) modulates activity of mouse brain histaminergic neurons (2022) (0)
Erratum zu “Antitussiva und Expektorantien”, Pharmazie in unserer Zeit 6/2008 (2009) (0)
Editorial: Pharmazie in unserer Zeit 6/2008 (2008) (0)
Therapeutic use as histamine h3 receptor-ligand of alkylamines containing no imidazole (1999) (0)
Neue Resveratrol Analoga mit potenten antikarzinogenen Wirkungen (2008) (0)
Editorial: Pharmazie in unserer Zeit 3/2006 (2006) (0)
Further Developments (2017) (0)
P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists (2004) (0)
P83 CNS delivery of a potent histamine H3-agonist via prodrugs (1994) (0)
Search for Histamine H3 Receptor Ligands with Combined Inhibitory Potency at Histamine N-Methyltransferase: w-Piperidinoalkanamine (2004) (0)
From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation (2017) (0)
Von der „Blobology“ zur atomaren Auflösung der Kryo-Elektronenmikroskopie (2020) (0)
Paramater für eine optimale Peroxidbleiche von Eukalyptus-Kraftzellstoffen : Druck - Temperatur - Konsistenz (1997) (0)
BF2.649 Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H 3 Receptor: Preclinical Pharmacology (2006) (0)
Histamine H3- Receptor Agonists and Antagonists: Chemical, Pharmacological, and Clinical Aspects (2008) (0)
Agonist compounds h3 histamine receptor for therapeutic use, pharmaceutical compositions that act as agonists of this receptor and preparation process. (1991) (0)
Verbundbauteil sowie Verfahren und Vorrichtung zu dessen Herstellung (2008) (0)
Elektronenmikroskopische 3D-Strukturbestimmung makromolekularer Komplexe. (2004) (0)
Bundestags-Hack - Merkel und der schicke Bär (2017) (0)
Verdichter- und Turbinenrad für eine Sekundärluftfördereinrichtung (2003) (0)
S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands (2003) (0)
Dedication to H. Schönenberger and Thanks to R. Hartmann (2004) (0)
Frontiers in GPCR Research (2005) (0)
DDDT_A_236586 371..393 (2020) (0)
Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket (2014) (0)
Supplementary Information GPCR Targeted Library Design : Novel Dopamine D 3 Receptor Ligands (2007) (0)
Editorial: Archiv der Pharmazie 9/2008 (2008) (0)
[Retinal cells against Parkinson disease]. (2006) (0)
Seminar Complex Nonlinear Processes in Chemistry and Biology (2009) (0)
Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. (2023) (0)
Overdose of the histamine H3 inverse agonist pitolisant increases thermal pain thresholds (2012) (0)
FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase (2015) (0)
5. Histamine receptor expression¶Impact of lipophilicity on the pharmacological properties of histamine H3-receptor antagonists of the cycloalkyl carbamate class (2002) (0)
Acknowledgement to Referees for Pharmacology 2010 (2010) (0)
Designs that Enrich Lives: Archiv der Pharmazie 10/2007 (2007) (0)
Structure, Function, and Potential Therapeutical Relevance of NMDA Receptors. Part 2. Therapy Concepts and Novel Receptor Ligands (2000) (0)
Proton pump inhibitors (2019) (0)
A New Face for Archiv der Pharmazie (2005) (0)
Erratum (1994) (0)
General Construction Pattern of Histamine H3‐Receptor Antagonists: Change of a Paradigm. (1998) (0)
Das Vorkommen von CD44 und seinen Isoformen unter orthologischen und pathologischen Bedingungen = Occurrence of CD44 and its isoforms under orthological and pathological conditions (1993) (0)
FOR A ROLE OF SYNERGISTIC D 1 Receptor Heteromers : INDICATIONS 3 D − 1 Identification of Dopamine D Mechanisms of Signal Transduction : (2008) (0)
STRIATUM RECEPTOR INTERACTIONS IN THE D3 - FOR A ROLE OF SYNERGISTIC D1 Receptor Heteromers: INDICATIONS 3 D - 1 Identification of Dopamine D Mechanisms of Signal Transduction: (2014) (0)
Neues Buch: Burger's Medicinal Chemistry & Drug Discovery von Donald J. Abraham (2004) (0)
FC22 development of A[125I]labelled histamine H3-receptor antagonist (1994) (0)
Chapter 10 Perspectives in H4R Research and Therapeutic Exploitation (2013) (0)

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