Hongtao Yu
#168,552
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Pharmacology researcher
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Hongtao Yumedical Degrees
Medical
#3497
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#3968
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Pharmacology
#443
World Rank
#497
Historical Rank
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Medical
Hongtao Yu's Degrees
- PhD Pharmacology University of California, San Francisco
- Masters Pharmacology University of California, San Francisco
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)Hongtao Yu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins (2016) (618)
- The spindle checkpoint, aneuploidy, and cancer (2004) (549)
- SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. (2011) (466)
- Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer (2011) (438)
- Human cohesin compacts DNA by loop extrusion (2019) (378)
- Regulation of APC-Cdc20 by the spindle checkpoint. (2002) (369)
- PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. (2006) (359)
- The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins (2007) (348)
- Cdc20: a WD40 activator for a cell cycle degradation machine. (2007) (339)
- The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. (2002) (327)
- The Mad2 spindle checkpoint protein has two distinct natively folded states (2004) (310)
- Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. (2006) (309)
- Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. (2004) (307)
- Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis (2004) (277)
- Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair (2005) (258)
- Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double‐strand breaks (2006) (253)
- Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. (2006) (248)
- Conformation‐specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint (2004) (235)
- Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 (2000) (218)
- p31comet Blocks Mad2 Activation through Structural Mimicry (2007) (208)
- Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. (2005) (208)
- Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C (2014) (206)
- Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. (2007) (194)
- ATP binding and ATP hydrolysis play distinct roles in the function of 26S proteasome. (2006) (190)
- FWD1‐mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation (2003) (175)
- A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. (2004) (171)
- Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C (2015) (168)
- Structural insights into histone lysine demethylation. (2010) (167)
- Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. (2006) (164)
- Mitotic transcription and waves of gene reactivation during mitotic exit (2017) (164)
- Structural basis of histone demethylation by LSD1 revealed by suicide inactivation (2007) (164)
- Systematic Identification and Analysis of Mammalian Small Ubiquitin-like Modifier Substrates* (2005) (153)
- Protein metamorphosis: the two-state behavior of Mad2. (2008) (150)
- Structure of cohesin subcomplex pinpoints direct shugoshin–Wapl antagonism in centromeric cohesion (2014) (137)
- Tracking spindle checkpoint signals from kinetochores to APC/C. (2013) (132)
- Two Distinct Pathways for Inhibiting Pds1 Ubiquitination in Response to DNA Damage* (2003) (131)
- The Smc complexes in DNA damage response (2012) (129)
- Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation. (2015) (124)
- Phospho-H2A and Cohesin Specify Distinct Tension-Regulated Sgo1 Pools at Kinetochores and Inner Centromeres (2013) (121)
- Regulation of the Anaphase-promoting Complex by the Dual Specificity Phosphatase Human Cdc14a* (2001) (117)
- Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model (2006) (116)
- A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling (2017) (114)
- Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores (2015) (114)
- Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis (2013) (112)
- Cryo-EM structure of the human cohesin-NIPBL-DNA complex (2020) (110)
- HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. (2005) (110)
- Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5 (2018) (109)
- Structural insights into the TRIM family of ubiquitin E3 ligases (2014) (106)
- Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. (2008) (105)
- Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint (2007) (103)
- Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting (2012) (101)
- Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics. (2016) (99)
- Mutual regulation between the spindle checkpoint and APC/C. (2011) (95)
- Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy (2016) (95)
- Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer (2008) (93)
- The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation (2016) (93)
- Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex (2019) (90)
- Structural analysis of human Cdc20 supports multisite degron recognition by APC/C (2012) (88)
- Phosphorylation-enabled binding of Sgo1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis (2012) (88)
- PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution (2011) (83)
- Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. (2007) (83)
- Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. (2008) (82)
- ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers (2008) (80)
- Structural basis of the activation of type 1 insulin-like growth factor receptor (2019) (80)
- Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity (2006) (80)
- Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl (2012) (80)
- Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells (2011) (79)
- Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis (2016) (74)
- KEN-Box-dependent Degradation of the Bub1 Spindle Checkpoint Kinase by the Anaphase-promoting Complex/Cyclosome* (2006) (72)
- The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores (2016) (72)
- Structural basis of cohesin cleavage by separase (2016) (72)
- Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression (2017) (66)
- Structure of the human cohesin inhibitor Wapl (2013) (66)
- The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling (2015) (64)
- Identification of Two Novel Components of the Human NDC80 Kinetochore Complex*[boxs] (2004) (62)
- Degradation of origin recognition complex large subunit by the anaphase‐promoting complex in Drosophila (2003) (61)
- A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo. (2005) (59)
- Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface (1995) (59)
- Bub1 Multitasking in Mitosis (2005) (58)
- Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31comet (2011) (58)
- Crm1-Mediated Nuclear Export of Cdc14 is Required for the Completion of Cytokinesis in Budding Yeast (2005) (57)
- The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis* (2014) (54)
- 1H and 15N assignments and secondary structure of the Src SH3 domain (1993) (54)
- Multiple Anaphase-promoting Complex/Cyclosome Degrons Mediate the Degradation of Human Sgo1* (2009) (53)
- Familial STAG2 germline mutation defines a new human cohesinopathy (2017) (53)
- Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling (2019) (52)
- PUMILIO hyperactivity drives premature aging of Norad-deficient mice (2018) (48)
- Structure of human GABAB receptor in an inactive state (2020) (48)
- Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition (2010) (46)
- Genome‐wide siRNA screen reveals coupling between mitotic apoptosis and adaptation (2014) (46)
- MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion (2018) (45)
- Structural basis of tubulin detyrosination by vasohibins (2019) (43)
- The BUB3-BUB1 Complex Promotes Telomere DNA Replication. (2018) (43)
- Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation (2016) (38)
- Kinase Signaling in the Spindle Checkpoint* (2009) (38)
- Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan. (2019) (38)
- The Mad 2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad 1 or (2002) (37)
- The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability (2014) (36)
- Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs (2010) (36)
- Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion (2018) (33)
- Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. (2009) (33)
- Human SMC 5 / 6 complex promotes sister chromatid homologous recombination by recruiting the SMC 1 / 3 cohesin complex to double-strand breaks (2006) (32)
- Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint (2007) (31)
- Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assay. (2004) (30)
- Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing (2017) (30)
- Regulation of APC – Cdc 20 by the spindle checkpoint (30)
- Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl (2017) (30)
- Structure of the Mad 2 spindle assembly checkpoint protein and its interaction with Cdc 20 (2000) (29)
- Structure of an intermediate conformer of the spindle checkpoint protein Mad2 (2015) (28)
- Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc14* (2004) (26)
- Regulation of sister chromatid cohesion during the mitotic cell cycle (2015) (26)
- Graded requirement for the spliceosome in cell cycle progression (2015) (26)
- The SMC5/6 Complex Maintains Telomere Length in ALT Cancer Cells through Sumoylation of Telomere‐Binding Proteins (2007) (24)
- Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting. (2014) (23)
- Sumoylation promotes optimal APC/C activation and timely anaphase (2018) (22)
- Regulation of CDC14: pathways and checkpoints of mitotic exit. (2003) (21)
- Distinguishing “Looped-Out” and “Stacked-In” DNA Bulge Conformation Using Fluorescent 2-Aminopurine Replacing a Purine Base (2002) (20)
- Scc 2 Is a Potent Activator of Cohesin ’ s ATPase that Promotes Loading by Binding Scc 1 without Pds 5 Graphical Abstract Highlights (2018) (19)
- Structural activation of Mad 2 in the mitotic spindle checkpoint : the two-state Mad 2 model versus the Mad 2 template model (17)
- Shaping of the 3D genome by the ATPase machine cohesin (2020) (16)
- Chk1: a double agent in cell cycle checkpoints. (2007) (15)
- The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation (2018) (15)
- Cryo-EM structure of VASH1-SVBP bound to microtubules (2020) (15)
- Insights into Mad 2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad 2 Dimer (2008) (14)
- Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy. (2008) (13)
- TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling (2021) (9)
- Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment (2019) (8)
- Multiple interactions between Scc1 and Scc2 activate cohesin’s DNA dependent ATPase and replace Pds5 during loading (2017) (8)
- Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion* (2016) (8)
- Spindle Checkpoint Regulators in Insulin Signaling (2018) (7)
- MCM 2 – 7-dependent cohesin loading during S phase 2 promotes sister-chromatid cohesion 3 4 (2018) (7)
- Magic Acts with the Cohesin Ring. (2016) (7)
- Mitosis: Short-Circuiting Spindle Checkpoint Signaling (2012) (5)
- Partner switching for Ran during the mitosis dance (2018) (5)
- Functional redundancy between Cdc20 ubiquitination and p31comet (2012) (5)
- A protective chaperone for the kinetochore adaptor Bub3. (2014) (5)
- Cdh1 is a HECT of an activator. (2011) (4)
- Identification of SUMO targets through in vitro expression cloning. (2009) (4)
- CTCF and R-loops are boundaries of cohesin-mediated DNA looping (2022) (4)
- Sgo1 as a guardian of chromosome stability (2012) (4)
- Tango between ubiquitin ligase and deubiquitinase keeps cyclin A tag free. (2011) (4)
- Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state (2022) (4)
- The complexity of life and death decisions in mitosis (2014) (3)
- Author response: Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex (2019) (3)
- Structure of the Symmetric Mad2 Dimer (2008) (3)
- A Method for SUMO Modification of Proteins in vitro (2018) (3)
- PP2A as a mercenary for warring kinases in the egg (2007) (3)
- Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc 14 (2004) (2)
- Purification and assay of Mad2: a two-state inhibitor of anaphase-promoting complex/cyclosome. (2005) (2)
- Cyclin A Turns on Bora to Light the Path to Mitosis. (2018) (2)
- STAG2 promotes the myelination transcriptional program in oligodendrocytes (2021) (2)
- Chromosome Biology: Wapl Spreads Its Wings (2013) (2)
- Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling (2019) (1)
- Ribosomal RNA regulates chromosome clustering during mitosis (2022) (1)
- Biochemical and Functional Assays of Human Cohesin-Releasing Factor Wapl. (2017) (1)
- Chromosome Condensation and Cohesion (2010) (1)
- Phosphorylation propels p31comet for mitotic exit (2015) (1)
- Familial STAG2 germline mutation defines a new human cohesinopathy (2017) (1)
- DNA capture and loop extrusion dynamics by cohesin-NIPBL (2022) (1)
- CENP-T bears the load in mitosis (2018) (1)
- Mad revival of cancer (2010) (1)
- Molecular Mechanism of the Spindle Checkpoint (2007) (1)
- Author response: A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling (2017) (1)
- Decision letter: The structure of the yeast Ctf3 complex (2019) (0)
- NIP45 Promotes Telomere Targeting to PML Bodies in ALT Cells (2012) (0)
- Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing (2017) (0)
- Structural Basis for the Inhibition of the LSD 1 Histone Demethylase by the Antidepressant rans-2-Phenylcyclopropylamine (0)
- A mad partner for Shugoshin in meiosis (2011) (0)
- Structure of Human Mad1 C‐terminal Domain Reveals Its Kinetochore‐Targeting Function (2012) (0)
- Author response: Sumoylation promotes optimal APC/C activation and timely anaphase (2018) (0)
- Research Highlight Cohesin: A Multi-purpose Chromatin Glue (2009) (0)
- Decision letter: Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1 (2019) (0)
- Decision letter: The structure of the Ctf19c/CCAN from budding yeast (2019) (0)
- Structural basis of spindle checkpoint activation and inactivation by Mad2 and p31comet (2008) (0)
- Cohesin: a multi-purpose chromatin glue. (2009) (0)
- Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct (2007) (0)
- Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ile37Ala (2005) (0)
- Developmental Cell Previews Chk 1 : A Double Agent in Cell Cycle Checkpoints (0)
- The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation (2018) (0)
- Decision letter: Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3 (2020) (0)
- How does cohesin organize the 3D genome? (2022) (0)
- Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ser94Gly (2005) (0)
- Author response: MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion (2018) (0)
- Human ubiquitin-conjugating enzyme (E2) UbcH5b mutant Ile88Ala (2005) (0)
- Mitotic Regulators and the SHP2-MAPK Pathway Promote Insulin Receptor Endocytosis and Feedback Regulation of Insulin Signaling (2018) (0)
- Author Correction: Structure of human GABAB receptor in an inactive state (2020) (0)
- The crystal structure of the heterochromatin protein 1 beta chromoshadow domain complexed with a peptide from Shugoshin 1 (2011) (0)
- Regulation of sister chromatid cohesion during the mitotic cell cycle (2015) (0)
- Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type (2005) (0)
- The Smc complexes in DNA damage response (2012) (0)
- Targeting the Spindle Checkpoint in Cancer Chemotherapy (2008) (0)
- Crystal Structure of the Mad2 Dimer (2010) (0)
- Crystal Structure of the Cohesin Loader Scc2 (2017) (0)
- Human cohesin inhibitor WapL (2013) (0)
- Ribosomal RNA regulates chromosome clustering during mitosis (2022) (0)
- CENP-T bears the load in mitosis (2018) (0)
- Author response: The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores (2016) (0)
- Chaetomium thermophilum cohesin loader SCC2, C-terminal fragment (2016) (0)
- Abstract 3430: TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling (2019) (0)
- Abstract 1137: Bub1 is a key regulator of TGF-β signaling (2014) (0)
- Decision letter: ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL (2019) (0)
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What Schools Are Affiliated With Hongtao Yu?
Hongtao Yu is affiliated with the following schools:
