Howard Cedar
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Israeli American biochemist
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#230
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Biology
Why Is Howard Cedar Influential?
(Suggest an Edit or Addition)According to Wikipedia, Howard Chaim Cedar is an Israeli American biochemist who works on DNA methylation, a mechanism that turns genes on and off. Biography Howard Chaim Cedar was born in the United States. He received a bachelor's degree from Massachusetts Institute of Technology and, in 1970, received an M.D. and a PhD from New York University. He is married to Zipora, a psychodramatist, and has six children, Joseph , Dahlia, Noa, Yoav, Yonatan and Daniel, and 24 grandchildren.
Howard Cedar's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Linking DNA methylation and histone modification: patterns and paradigms (2009) (2124)
- Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer (2007) (1180)
- Allelic inactivation regulates olfactory receptor gene expression (1994) (1028)
- Spl elements protect a CpG island from de novo methylation (1994) (786)
- Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. (1992) (738)
- Sequence specificity of methylation in higher plant DNA (1981) (688)
- DNA methylation and gene expression (1991) (680)
- G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis (2006) (670)
- DNA methylation and gene activity (1988) (627)
- DNA methylation affects the formation of active chromatin (1986) (533)
- Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal (1993) (519)
- DNA Methylation in Cancer and Aging. (2016) (502)
- Evidence for an instructive mechanism of de novo methylation in cancer cells (2006) (501)
- De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes (2008) (457)
- Identification of tissue-specific cell death using methylation patterns of circulating DNA (2016) (437)
- DNA methylation dynamics in health and disease (2013) (436)
- Programming of DNA methylation patterns. (2012) (406)
- Substrate and sequence specificity of a eukaryotic DNA methylase (1982) (404)
- Allele-specific replication timing of imprinted gene regions (1993) (394)
- Developmental programming of CpG island methylation profiles in the human genome (2009) (392)
- DNA methylation and genomic imprinting (1994) (362)
- The ontogeny of allele‐specific methylation associated with imprinted genes in the mouse. (1993) (359)
- DNA methylation represses transcription in vivo (1999) (352)
- The role of DNA methylation in setting up chromatin structure during development (2003) (345)
- Principles of DNA methylation and their implications for biology and medicine (2018) (330)
- Role of DNA methylation in the regulation of transcription. (1994) (324)
- Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. (1993) (319)
- Delineation of DNA replication time zones by fluorescence in situ hybridization. (1992) (304)
- DNA methylation models histone acetylation (1998) (275)
- Methylation of CpG sequences in eukaryotic DNA (1981) (271)
- Replication structure of the human & beta;-globin gene domain (1993) (269)
- Asynchronous replication and allelic exclusion in the immune system (2001) (265)
- In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. (1982) (252)
- Kappa chain monoallelic demethylation and the establishment of allelic exclusion. (1998) (233)
- DNA methylation, biochemistry, and biological significance (1984) (233)
- A role for nuclear NF–κB in B–cell–specific demethylation of the Igκ locus (1996) (220)
- Clonal inheritance of the pattern of DNA methylation in mouse cells. (1982) (220)
- Effect of regional DNA methylation on gene expression. (1985) (213)
- Intragenic DNA spacers interrupt the ovalbumin gene. (1978) (192)
- Mapping replication units in animal cells (1989) (189)
- Epigenetics of haematopoietic cell development (2011) (187)
- Distribution of 5-methylcytosine in chromatin. (1977) (186)
- Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. (1984) (181)
- Asynchronous replication of imprinted genes is established in the gametes and maintained during development (1999) (181)
- Direct detection of methylated cytosine in DNA by use of the restriction enzyme MspI. (1979) (173)
- DNA methylation: A molecular lock (1997) (172)
- Epigenetic ontogeny of the Igk locus during B cell development (2005) (172)
- DNA Demethylation In Vitro: Involvement of RNA (1996) (171)
- Establishment of transcriptional competence in early and late S phase (2002) (170)
- Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. (1973) (165)
- Developmental changes in methylation of spermatogenesis–specific genes include reprogramming in the epididymis (1994) (164)
- Replicating by the clock (2003) (163)
- B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence (1994) (161)
- Expression of a cloned adenovirus gene is inhibited by in vitro methylation. (1982) (160)
- DNA methylation and development. (1990) (157)
- Methylation of foreign DNA sequences in eukaryotic cells. (1980) (154)
- Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica : II. Effect of serotonin and dopamine (1972) (153)
- Role of DNA Methylation in Stable Gene Repression* (2007) (151)
- Production of l-Asparaginase II by Escherichia coli (1968) (144)
- Demethylation of CpG islands in embryonic cells (1991) (141)
- DNA replication timing of the human beta-globin domain is controlled by histone modification at the origin. (2008) (137)
- Dynamics of demethylation and activation of the α-actin gene in myoblasts (1990) (135)
- Mapping of DNAase I sensitive regions on mitotic chromosomes (1984) (133)
- Dynamics of DNA methylation during development (1993) (128)
- Localization of the two-L-asparaginases in anaerobically grown Escherichia coli. (1967) (124)
- Maintenance of Epigenetic Information. (2016) (123)
- Transcription of chromatin in vitro. (1973) (118)
- The imprinting box of the Prader-Willi/Angelman syndrome domain (2000) (116)
- Gamete–specific methylation correlates with imprinting of the murine Xist gene (1995) (116)
- Muscle-specific activation of a methylated chimeric actin gene (1986) (115)
- Active gene sequences are undermethylated. (1981) (110)
- Pattern of methylation of two genes coding for housekeeping functions. (1983) (110)
- The imprinting mechanism of the Prader–Willi/Angelman regional control center (2002) (96)
- The asparagine synthetase of Escherhic coli. I. Biosynthetic role of the enzyme, purification, and characterization of the reaction products. (1969) (95)
- Silence of the genes — mechanisms of long-term repression (2005) (95)
- Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica : I. Increased synthesis in response to synaptic stimulation (1972) (94)
- In situ nick-translation distinguishes between active and inactive X chromosomes (1983) (91)
- Active genes are sensitive to deoxyribonuclease I during metaphase. (1982) (88)
- A stepwise epigenetic process controls immunoglobulin allelic exclusion (2004) (86)
- Developmental regulation of DNA replication timing at the human β globin locus (2001) (84)
- Tissue-specific DNA demethylation is required for proper B-cell differentiation and function (2016) (82)
- Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis (2000) (82)
- Regulation of mouse satellite DNA replication time. (1988) (81)
- Organization of 5-methylcytosine in chromosomal DNA. (1978) (80)
- Methylation patterns of testis-specific genes. (1991) (80)
- Shifts in replication timing actively affect histone acetylation during nucleosome reassembly. (2009) (79)
- DNA methylation and embryogenesis. (1993) (77)
- Selective degradation of integrated murine leukemia proviral DNA by deoxyribonucleases (1977) (76)
- DNA methylation dynamics in health and disease (2013) (74)
- Restriction enzyme digestion of hemimethylated DNA. (1981) (71)
- Gender-specific postnatal demethylation and establishment of epigenetic memory (2015) (66)
- DNA methylation in eukaryotic cells. (1984) (66)
- Methylation of replicating and post-replicated mouse L-cell DNA. (1983) (61)
- Differential accessibility at the κ chain locus plays a role in allelic exclusion (2002) (61)
- Allelic inactivation of rDNA loci. (2009) (60)
- Choreography of Ig allelic exclusion. (2008) (60)
- Gene expression: The amazing demethylase (1999) (60)
- Reconstitution of a deoxyribonuclease I-sensitive structure on active genes. (1980) (59)
- B cell-specific demethylation: a novel role for the intronic kappa chain enhancer sequence. (1994) (59)
- A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus. (1996) (57)
- Biallelic Germline Transcription at the κ Immunoglobulin Locus (2003) (57)
- L-asparaginase II of Escherichia coli. Studies on the enzymatic mechanism of action. (1971) (55)
- Effect of in vitro DNA methylation on beta-globin gene expression. (1988) (54)
- The structure of the globin genes in chromatin. (1975) (53)
- Fine Tuning of Globin Gene Expression by DNA Methylation (2006) (50)
- The asparagine synthetase of Escherichia coli. II. Studies on mechanism. (1969) (48)
- Effect of CpG methylation on Msp I. (1983) (46)
- Molecular rules governing de novo methylation in cancer. (2014) (46)
- Contribution of epigenetic mechanisms to variation in cancer risk among tissues (2017) (46)
- Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts. (1998) (45)
- DNA hypomethylation causes an increase in DNase-I sensitivity and an advance in the time of replication of the entire inactive X chromosome (2004) (45)
- Regulated expression of an introduced MHC H–2Kbm1 gene in murine embryonal carcinoma cells (1984) (44)
- Nick translation of active genes in intact nuclei. (1979) (44)
- Developmental regulation of DNA replication timing at the human beta globin locus. (2001) (43)
- Metabolism of acetylcholine in the nervous system of Aplysia californica. I. Source of choline and its uptake by intact nervous tissue (1975) (43)
- CTCF Elements Direct Allele-Specific Undermethylation at the Imprinted H19 Locus (2004) (43)
- Epigenetic mechanisms that regulate antigen receptor gene expression. (2003) (42)
- Developmental regulation of immune system gene rearrangement. (1999) (42)
- Postnatal DNA demethylation and its role in tissue maturation (2018) (41)
- Imprinting: focusing on the center. (2000) (41)
- Clonal allelic predetermination of immunoglobulin-κ rearrangement (2012) (40)
- Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers (2017) (39)
- Dynamics of demethylation and activation of the alpha-actin gene in myoblasts. (1990) (38)
- Effect of DNA methylation on gene expression. (1983) (34)
- In vitro methylation of DNA with Hpa II methylase. (1981) (33)
- Transcription of DNA and chromatin with calf thymus RNA polymerase B in vitro. (1975) (33)
- Establishment of methylation patterns in ES cells (2013) (32)
- Methylation of adenovirus genes in transformed cells and in vitro: influence on the regulation of gene expression? (1981) (31)
- Regulation of imprinting: A multi‐tiered process (2003) (31)
- Epigenetic crosstalk. (2001) (31)
- Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. (2007) (29)
- The role of DNA demethylation during development (1997) (29)
- A multistep mechanism for the activation of rearrangement in the immune system (2003) (29)
- Demethylation of genes in animal cells. (1990) (28)
- Differential accessibility at the kappa chain locus plays a role in allelic exclusion. (2002) (26)
- Epigenetic control of recombination in the immune system. (2010) (26)
- Nuclease sensitivity of active chromatin. (1980) (26)
- Chromatin template activity and chromatin structure. (1974) (23)
- Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis (2015) (22)
- DNase I sensitivity in facultative and constitutive heterochromatin (2005) (22)
- 12 Temporal Order of DNA Replication (1996) (21)
- Effect of in vitro DNA methylation on ,-globin gene expression (21)
- Reprogramming of DNA Replication Timing (2010) (20)
- Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus (2007) (19)
- News you can use (1993) (18)
- Aberrant DNA Methylation in ES Cells (2014) (18)
- The role of XbaI polymorphism of the apolipoprotein B gene in determining levels and covariability of lipid and lipoprotein variables in a sample of Israeli offspring with family history of myocardial infarction. (1993) (18)
- Genome-Wide De Novo Methylation in Epithelial Ovarian Cancer (2010) (18)
- Demethylation and the establishment of kappa allelic exclusion. (1999) (17)
- Epigenetic silencing during early lineage commitment (2009) (16)
- Topographical distribution of 5-methylcytosine in animal and plant DNA (1982) (15)
- Methylation of chromatin DNA. (1976) (14)
- Introduction and General Overview (1984) (14)
- XbaI polymorphism of the apolipoprotein B gene and plasma lipid and lipoprotein response to dietary fat and cholesterol: a clinical trial (1993) (14)
- 5-aza-C-induced changes in the time of replication of the X chromosomes of Microtus agrestis are followed by non-random reversion to a late pattern of replication (2004) (12)
- Role of transcription complexes in the formation of the basal methylation pattern in early development (2018) (12)
- Control of RNA synthesis by chromatin proteins. (1976) (12)
- Annealing and hybridization properties of herpes simplex virus type 1 DNA. (1976) (11)
- Chromosome structure and eukaryotic gene organization. (1991) (11)
- Programming asynchronous replication in stem cells (2017) (10)
- Gene repression paradigms in animal cells. (2004) (10)
- Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica (1972) (9)
- Clonally stable Vκ allelic choice instructs Igκ repertoire (2017) (9)
- Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome. (2017) (9)
- Cyclic Adenosine Monophosphate in the (1972) (9)
- Allele-specific structures in the mouse Igf2-H19 domain. (1993) (8)
- Chromosomal coordination and differential structure of asynchronous replicating regions (2021) (8)
- Determining gestational age using genome methylation profile: A novel approach for fetal medicine (2019) (8)
- Action at a distance (1995) (7)
- A Novel Pax5-Binding Regulatory Element in the Igκ Locus (2014) (6)
- A temperature-sensitive mutation in asparaginyl-tRNA synthetase causes cell-cycle arrest in early S phase. (1989) (6)
- The kinetics of E. coli RNA polymerase. (1976) (5)
- Annotating the genome by DNA methylation. (2017) (5)
- DNA Methylation andGeneExpression (1991) (4)
- Quantification of newly synthesized virus RNA in moloney murine leukaemia virus-infected cells. (1980) (3)
- Topographical Distribution of5-Methylcytosine inAnimaland (1982) (3)
- RNA chain elongation on a chromatin template. (1976) (2)
- Production ofL-Asparaginase II byEscherichia coli (1968) (2)
- The role of DNA methylation in genome-wide gene regulation during development. (2022) (2)
- Genomic imprinting. Action at a distance. (1995) (2)
- Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica (1972) (1)
- Epigenetic mechanism of FMR 1 inactivation in Fragile X syndrome (2017) (1)
- Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development (2021) (1)
- Activation of the endogenous proviral genes in mouse cells is not followed by increased sensitivity to deoxyribonuclease I digestion. (1979) (1)
- DNA methylation during development (2010) (1)
- Clonally stable Vk allelic choice instructs Igk repertoire (2017) (1)
- (DNA-mediated gene transfer/hemimethylated DNA/maintenance Im (2016) (0)
- Variations in DNA methylation dur in vivo and in vitro (2016) (0)
- Postnatal DNA demethylation and its role in tissue maturation (2018) (0)
- DNA METHYLATION: BRIDGING THE GAP BETWEEN GENES AND FUNCTION (2017) (0)
- Pattern of methylation of two gene housekeeping functions (DNA methylation/Chinese hamster adenine phosphoribosyltransfers (2016) (0)
- Proceedings: In vitro transcription from chromatin of slime molds. (1975) (0)
- Expression of Nurr1 and 8-OHdG in NHEK cells by immunocytochemistry and further confirmation by western blot. (2013) (0)
- 1087 THERAPEUTIC EFFECT OF S-ADENOSYLMETHIONINE ON LIVER TUMOR DEVELOPMENT IN MURINE INFLAMMATION-MEDIATED MODEL IS ASSOCIATED WITH INCREASED EXPRESSION OF TUMOR SUPPRESSOR GENES AND CELL CYCLE ARREST (2013) (0)
- Muscle injury causes long-term changes in stem-cell DNA methylation. (2022) (0)
- Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts (2021) (0)
- Hybridization analysis of the methylated bases of Escherichia coli DNA. (1980) (0)
- Orchestration of DNA Methylation (2008) (0)
- Synthesis ofGlobin Ribonucleic AcidfromDuck-Reticulocyte Chromatin InVitro (1973) (0)
- The Specific Template Activity of Chromatin (2008) (0)
- Reconstitution of a deoxyribonuclea active genes (high-mobility group proteins/chromatin/gene expression) (2016) (0)
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