Howard E. Gendelman
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American physician-scientist
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Medical Philosophy
Howard E. Gendelman's Degrees
- Masters Medicine University of California, San Francisco
- PhD Pharmacology University of California, San Francisco
Why Is Howard E. Gendelman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Howard E. Gendelman is an American physician-scientist whose research intersects the disciplines of neuroimmunology, pharmacology, and infectious diseases. Gendelman was born in Philadelphia, Pennsylvania. His research is focused on harnessing immune responses for therapeutic gain in HIV/AIDS and Neurodegenerative disease. He is the Margaret R. Larson Professor of infectious diseases and internal medicine at the University of Nebraska Medical Center in Omaha.
Howard E. Gendelman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone (1986) (2892)
- Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. (1986) (1706)
- A call for transparent reporting to optimize the predictive value of preclinical research (2012) (1036)
- The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. (1994) (952)
- Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes (1988) (819)
- Dementia Associated with the Acquired Immunodeficiency Syndrome (1995) (469)
- Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease (2007) (404)
- Oxidative stress and the pathogenesis of neurodegenerative disorders. (2007) (402)
- Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus (1986) (398)
- Diagnostics for SARS-CoV-2 infections (2021) (380)
- Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms (1993) (375)
- The macrophage in the persistence and pathogenesis of HIV infection. (1989) (373)
- The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections (2020) (349)
- Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV- associated neurological disease (1995) (346)
- Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages (1986) (341)
- Slow, persistent replication of lentiviruses: role of tissue macrophages and macrophage precursors in bone marrow. (1985) (338)
- Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. (1996) (337)
- Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease (2010) (324)
- Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. (1986) (320)
- Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. (2004) (316)
- Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons (2008) (314)
- Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA (1995) (313)
- Interferon-γ and Tumor Necrosis Factor-α Regulate Amyloid-β Plaque Deposition and β-Secretase Expression in Swedish Mutant APP Transgenic Mice (2007) (308)
- Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson’s disease (2006) (307)
- Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study (1988) (306)
- Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia (1999) (301)
- Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. (1996) (291)
- Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. (1990) (274)
- Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes. (1991) (268)
- Cell-mediated drug delivery (2011) (250)
- Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease (2007) (243)
- Nanotechnology: A Focus on Nanoparticles as a Drug Delivery System (2006) (243)
- HIV-1 gp120 Compromises Blood–Brain Barrier Integrity and Enhance Monocyte Migration across Blood–Brain Barrier: Implication for Viral Neuropathogenesis (2007) (234)
- Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery. (2006) (232)
- Nanomedicine in the diagnosis and therapy of neurodegenerative disorders. (2007) (231)
- CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease (2012) (231)
- Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus (1987) (224)
- Inflammation and adaptive immunity in Parkinson's disease. (2012) (213)
- Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS1 (2009) (211)
- A Functional Transsulfuration Pathway in the Brain Links to Glutathione Homeostasis* (2006) (204)
- Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System1 (2000) (203)
- Nitrated alpha‐synuclein‐activated microglial profiling for Parkinson’s disease (2008) (201)
- Biochemical and Biologic Characterization of Exosomes and Microvesicles as Facilitators of HIV-1 Infection in Macrophages (2012) (195)
- Methamphetamine-Associated Psychosis (2011) (188)
- CNS expression of anti‐inflammatory cytokine interleukin‐4 attenuates Alzheimer's disease‐like pathogenesis in APP+PS1 bigenic mice (2010) (184)
- Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice (2019) (182)
- Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice (2008) (181)
- The Neurology of AIDS (1998) (177)
- Infections of the nervous system (2004) (176)
- A macrophage-nanozyme delivery system for Parkinson's disease. (2007) (171)
- Mononuclear phagocyte immunity and the neuropathogenesis of HIV‐1 infection (2003) (171)
- Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. (1998) (169)
- Nitrated α-Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets1 (2009) (165)
- Role of the β-Chemokine Receptors CCR3 and CCR5 in Human Immunodeficiency Virus Type 1 Infection of Monocytes and Microglia (1998) (165)
- Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. (2007) (164)
- Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease (2009) (161)
- Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. (2005) (161)
- HIV‐1‐Associated Dementia: A Metabolic Encephalopathy Perpetrated by Virus‐Infected and Immune‐Competent Mononuclear Phagocytes (2002) (160)
- The 2022 outbreak and the pathobiology of the monkeypox virus (2022) (160)
- Mononuclear phagocytes mediate blood‐brain barrier compromise and neuronal injury during HIV‐1‐associated dementia (2000) (158)
- Macrophages and the human immunodeficiency virus. (1990) (158)
- Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson's disease. (2010) (152)
- The neuropathogenesis of HIV‐1 infection (1994) (151)
- Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers. (2010) (147)
- Lymphotropic Virions Affect Chemokine Receptor-Mediated Neural Signaling and Apoptosis: Implications for Human Immunodeficiency Virus Type 1-Associated Dementia (1999) (143)
- Activation of the human immunodeficiency virus by herpes simplex virus type 1 (1987) (143)
- Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes. (1991) (143)
- Regulation of HIV replication in infected monocytes by IFN-alpha. Mechanisms for viral restriction. (1990) (138)
- Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages (2001) (138)
- Interferons in the persistence, pathogenesis, and treatment of HIV infection. (1992) (131)
- Facilitated Monocyte-Macrophage Uptake and Tissue Distribution of Superparmagnetic Iron-Oxide Nanoparticles (2009) (129)
- STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. (2008) (128)
- Human immunodeficiency virus type 1 in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages. (1989) (128)
- Macrophages as susceptible targets for HIV infection, persistent viral reservoirs in tissue, and key immunoregulatory cells that control levels of virus replication and extent of disease. (1990) (127)
- Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. (2007) (126)
- Neuroprotective Activities of Sodium Valproate in a Murine Model of Human Immunodeficiency Virus-1 Encephalitis (2003) (126)
- Overexpression of monocyte chemotactic protein-1/ CCL2 in β-amyloid precursor protein transgenic mice show accelerated diffuse β-amyloid deposition (2005) (126)
- NanoART, neuroAIDS and CNS drug delivery. (2009) (126)
- Human Immunodeficiency Virus Type 1 Pathobiology Studied in Humanized BALB/c-Rag2−/−γc−/− Mice (2006) (125)
- Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. (2010) (123)
- A model of human immunodeficiency virus encephalitis in scid mice. (1993) (122)
- Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease (2007) (119)
- Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants (1992) (119)
- Innate and adaptive immunity for the pathobiology of Parkinson's disease. (2009) (119)
- Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities (2008) (118)
- Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease (2013) (118)
- Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson’s disease (2007) (116)
- A Coat of Many Colors: Neuroimmune Crosstalk in Human Immunodeficiency Virus Infection (2009) (116)
- Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice (2012) (115)
- NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery. (2009) (114)
- Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases (2013) (113)
- CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction (2009) (108)
- Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome. (1995) (108)
- Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease (2012) (107)
- Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages. (2011) (107)
- Nanoformulated Antiretroviral Drug Combinations Extend Drug Release and Antiretroviral Responses in HIV-1-Infected Macrophages: Implications for NeuroAIDS Therapeutics (2010) (105)
- Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice (2011) (104)
- Efficiency of in situ hybridization as a function of probe size and fixation technique. (1985) (104)
- Human Immunodeficiency Virus Neurotropism: an Analysis of Viral Replication and Cytopathicity for Divergent Strains in Monocytes and Microglia (1998) (103)
- Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes (1994) (103)
- Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence (1988) (102)
- Persistent expression of Ia antigen and viral genome in visna-maedi virus-induced inflammatory cells. Possible role of lentivirus-induced interferon (1985) (100)
- Plasma levels of soluble CD14 and tumor necrosis factor-alpha type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection. (2001) (100)
- Neural immunity: Friend or foe? (2002) (100)
- Cell delivery of therapeutic nanoparticles. (2011) (99)
- Regulation of tissue inhibitor of metalloproteinase‐1 by astrocytes: Links to HIV‐1 dementia (2003) (98)
- HIV‐1‐infected and/or immune activated macrophages regulate astrocyte SDF‐1 production through IL‐1β (2006) (98)
- Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. (2007) (98)
- Mononuclear phagocytes as targets, tissue reservoirs, and immunoregulatory cells in human immunodeficiency virus disease. (1992) (95)
- Selection of a fixative for identifying T cell subsets, B cells, and macrophages in paraffin-embedded mouse spleen. (1983) (95)
- Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases. (2015) (94)
- CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease (2007) (93)
- Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis. (2010) (93)
- Cytokine-Stimulated, But Not HIV-Infected, Human Monocyte-Derived Macrophages Produce Neurotoxic Levels of l-Cysteine1 (2000) (92)
- Measles encephalomyelitis: Lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelination (1984) (91)
- A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes [published erratum appears in J Exp Med 1991 Jan 1;173(1):277] (1990) (89)
- CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice (2010) (89)
- Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages. (2007) (89)
- Tracking superparamagnetic iron oxide labeled monocytes in brain by high‐field magnetic resonance imaging (2003) (88)
- Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson’s disease trial (2017) (88)
- Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection (2011) (87)
- Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons (2020) (87)
- Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome. (2007) (86)
- HIV neurocognitive disorders. (2005) (86)
- Insights into the neurodegenerative process of Alzheimer's disease: a role for mononuclear phagocyte‐associated inflammation and neurotoxicity (1999) (85)
- Long-acting parenteral nanoformulated antiretroviral therapy: interest and attitudes of HIV-infected patients. (2013) (85)
- Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. (2005) (85)
- Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells. (2009) (85)
- Mononuclear Phagocyte Differentiation, Activation, and Viral Infection Regulate Matrix Metalloproteinase Expression: Implications for Human Immunodeficiency Virus Type 1-Associated Dementia (2001) (85)
- Neuromodulatory Activities of CD4+CD25+ Regulatory T Cells in a Murine Model of HIV-1-Associated Neurodegeneration1 (2009) (84)
- HIV-1 neuroimmunity in the era of antiretroviral therapy (2010) (82)
- GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice (2013) (81)
- Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia (2003) (81)
- Memantine Protects Hippocampal Neuronal Function in Murine Human Immunodeficiency Virus Type 1 Encephalitis (2004) (81)
- A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes (1991) (81)
- Neuroprotective Mechanisms of Lithium in Murine Human Immunodeficiency Virus-1 Encephalitis (2005) (80)
- Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. (2007) (80)
- A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy (2017) (80)
- Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections. (2013) (79)
- Creation of a long-acting nanoformulated dolutegravir (2018) (78)
- Impaired Spatial Cognition and Synaptic Potentiation in a Murine Model of Human Immunodeficiency Virus Type 1 Encephalitis (2002) (77)
- Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins. (2014) (76)
- Macrophage‐HIV interaction: viral isolation and target cell tropism (1990) (75)
- The cellular immunology of multiple sclerosis (1999) (74)
- Metabolic drift in the aging brain (2016) (74)
- Macrophage Bridging Conduit Trafficking of HIV-1 Through the Endoplasmic Reticulum and Golgi Network (2011) (72)
- Quantitative 1H Magnetic Resonance Spectroscopic Imaging Determines Therapeutic Immunization Efficacy in an Animal Model of Parkinson's Disease (2005) (72)
- The neuropathogenesis of HIV-1 infection. (1999) (72)
- Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120 (1992) (71)
- Active Targeted Macrophage-mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease. (2011) (70)
- Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues (2019) (70)
- Novel Delivery System Enhances Efficacy of Antiretroviral Therapy in Animal Model for HIV-1 Encephalitis (2007) (69)
- Bench-to-bedside translation of magnetic nanoparticles. (2014) (69)
- Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles (2017) (68)
- Restriction of HIV replication in infected T cells and monocytes by interferon-alpha. (1990) (68)
- Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies. (2014) (68)
- A double labeling technique for performing immunocytochemistry and in situ hybridization in virus infected cell cultures and tissues. (1985) (68)
- Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment (2003) (67)
- Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment (2009) (67)
- Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations. (2015) (67)
- Debate: “Is Increasing Neuroinflammation Beneficial for Neural Repair?” (2006) (67)
- Preclinical Pharmacokinetics and Tissue Distribution of Long-Acting Nanoformulated Antiretroviral Therapy (2013) (67)
- Inhibition of long‐term potentiation by interleukin‐8: Implications for human immunodeficiency virus‐1‐associated dementia (2003) (66)
- SARS-CoV-2 Infection Leads to Neurological Dysfunction (2020) (66)
- Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice. (2012) (66)
- Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases (2005) (66)
- Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery (2006) (66)
- HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: New insights into blood–brain barrier dysfunction for HIV-1-associated dementia (2007) (66)
- Macrophage endocytic trafficking of antiretroviral nanoparticles. (2011) (64)
- Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis (2016) (64)
- Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation (2007) (63)
- Rodent models for HIV-associated neurocognitive disorders (2012) (63)
- Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment. (1994) (63)
- Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease. (1991) (63)
- Brain region mapping using global metabolomics. (2014) (62)
- An experimental model system for HIV-1-induced brain injury. (1994) (61)
- TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia (2004) (61)
- CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease (2013) (60)
- SCID mice with HIV encephalitis develop behavioral abnormalities. (1998) (60)
- Hypersynchrony despite pathologically reduced beta oscillations in patients with Parkinson's disease: a pharmaco-magnetoencephalography study. (2014) (60)
- vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus (1996) (60)
- The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice. (1989) (59)
- Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders (2014) (59)
- T cell independent mechanism for copolymer‐1‐induced neuroprotection (2007) (59)
- Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice (2015) (58)
- Neuroregulatory Events Follow Adaptive Immune-Mediated Elimination of HIV-1-Infected Macrophages: Studies in a Murine Model of Viral Encephalitis1 (2004) (58)
- Macrophage‐induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV‐1 encephalitis (2005) (57)
- Neurodegenerative disorders and nanoformulated drug development. (2009) (57)
- Induction of IFN-alpha in peripheral blood mononuclear cells by HIV-infected monocytes. Restricted antiviral activity of the HIV-induced IFN. (1992) (57)
- AIDS‐associated progressive multifocal leukoencephalopathy (PML) (1990) (57)
- HIV-1 cellular and tissue replication patterns in infected humanized mice (2016) (56)
- Generation of Cytotoxic T Cells Against Virus-Infected Human Brain Macrophages in a Murine Model of HIV-1 Encephalitis1 (2002) (56)
- CSF proteomic fingerprints for HIV-associated cognitive impairment (2007) (56)
- Bridge between neuroimmunity and traumatic brain injury. (2013) (56)
- Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells. (2011) (55)
- Development of laboratory and animal model systems for HIV‐1 encephalitis and its associated dementia (1997) (55)
- AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. (2009) (55)
- HIV-1-associated dementia: a basic science and clinical perspective. (2002) (54)
- Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. (2011) (54)
- A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease (1985) (54)
- Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells (2012) (54)
- Long-acting slow effective release antiretroviral therapy (2017) (53)
- Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice (2014) (53)
- Regulation of Human Immunodeficiency Virus Type 1 Infection, β-Chemokine Production, and CCR5 Expression in CD40L-Stimulated Macrophages: Immune Control of Viral Entry (2001) (52)
- Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance (2014) (52)
- The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: relevance for HIV-1-associated dementia (2001) (51)
- Cytoskeletal Protein Transformation in HIV-1-Infected Macrophage Giant Cells1 (2007) (51)
- Nano-enabled delivery of diverse payloads across complex biological barriers. (2015) (50)
- Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines. (2015) (50)
- Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues. (2014) (50)
- Comparative manufacture and cell-based delivery of antiretroviral nanoformulations (2011) (50)
- Neurotheranostics as personalized medicines. (2019) (50)
- No direct neuronotoxicity by HIV-1 virions or culture fluids from HIV-1-infected T cells or monocytes. (1992) (50)
- CD 4+ T cells in the pathobiology of neurodegenerative disorders (2009) (49)
- Cellular and viral determinants that regulate HIV‐1 infection in macrophages (1994) (49)
- Nanocarrier vaccines for SARS-CoV-2 (2021) (49)
- Infection of human gastrointestinal cells by HIV-1. (1990) (48)
- Immunoregulation of a CB2 Receptor Agonist in a Murine Model of NeuroAIDS (2010) (48)
- Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice (2000) (48)
- Relative inefficiency of soluble recombinant CD4 for inhibition of infection by monocyte-tropic HIV in monocytes and T cells. (1990) (47)
- Proteomic Modeling for HIV-1 Infected Microglia-Astrocyte Crosstalk (2008) (47)
- Hippocampal synaptic dysfunction in a murine model of human immunodeficiency virus type 1 encephalitis (2003) (46)
- Review: neuronal injury in HIV infection. (1999) (46)
- HIV-1-Infected Astrocytes and the Microglial Proteome (2008) (46)
- Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease. (2016) (45)
- A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug (2020) (45)
- Expression of pro‐ and anti‐apoptosis gene products in brains from paediatric patients with HIV‐1 encephalitis (1997) (45)
- Monocyte Chemotactic Protein-1 Regulates Voltage-Gated K+ Channels and Macrophage Transmigration (2009) (45)
- Human Dendritic Cells Transduced with Herpes Simplex Virus Amplicons Encoding Human Immunodeficiency Virus Type 1 (HIV-1) gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Challenge (2005) (45)
- Neuroprotective Activities of CEP-1347 in Models of NeuroAIDS (2009) (45)
- Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases (2010) (45)
- Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages. (2008) (44)
- The cortical signature of symptom laterality in Parkinson's disease (2017) (44)
- Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids (2015) (44)
- Blood-borne macrophage-neural cell interactions hitchhike on endosome networks for cell-based nanozyme brain delivery. (2012) (44)
- Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS (2007) (44)
- Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs (2017) (43)
- EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment (2018) (43)
- The regulation of quinolinic acid in human immunodeficiency virus-infected monocytes. (1996) (43)
- The inability of human immunodeficiency virus to infect chimpanzee monocytes can be overcome by serial viral passage in vivo (1991) (43)
- Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases. (2019) (43)
- Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease (2016) (42)
- C1q–calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease (2003) (41)
- Molecular characterization of a polymerase mutant human immunodeficiency virus. (1987) (41)
- Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders (2020) (40)
- UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. (2011) (40)
- Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice (2019) (40)
- Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes (2014) (39)
- Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution (2018) (39)
- Glycogen Synthase Kinase 3 Beta (GSK-3β) as a Therapeutic Target in NeuroAIDS (2007) (39)
- Molecular Characterization of a Putative Antiretroviral Transcriptional Factor, OTK181 (2004) (38)
- Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function (2003) (38)
- Murine Motor and Behavior Functional Evaluations for Acute 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Intoxication (2012) (38)
- Infection of macrophages with lymphotropic human immunodeficiency virus type 1 can be arrested after viral DNA synthesis (1993) (38)
- Copolymer-1 Induces Adaptive Immune Anti-inflammatory Glial and Neuroprotective Responses in a Murine Model of HIV-1 Encephalitis1 (2007) (38)
- Macrophages, chemokines and neuronal injury in HIV-1-associated dementia. (2002) (38)
- Landmark Optimization Using Local Curvature for Point-Based Nonlinear Rodent Brain Image Registration (2011) (38)
- Advances in neuroimaging for HIV-1 associated neurological dysfunction: clues to the diagnosis, pathogenesis and therapeutic monitoring. (2004) (38)
- Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice (2018) (37)
- Neuropathologic and neuroinflammatory activities of HIV‐1‐infected human astrocytes in murine brain (2006) (37)
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- Book Reviews (2006) (0)
- Multipolymer microsphere delivery of SARS-CoV-2 antigens (2022) (0)
- HIV-1 Infection in Macrophages of Exosomes and Microvesicles as Facilitators Biochemical and Biologic Characterization of (2012) (0)
- IDENTIFICATION AND BIOLOGICAL CHARACTERIZATION OF EXTRACELLULAR VESICLE PROTEINS FOR PROPAGATION AND SPREAD OF TAU (2019) (0)
- Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice (2019) (0)
- Neuropharmacologic Approaches to Restore the Brain’s Microenvironment (2016) (0)
- The neuroimmune mechanisms for HIV-tπ dementia: The role of mononuclear phagocytes and astrocytes in virus-related brain disease (1995) (0)
- The neuroimmunology of HIV-1 dementia (1998) (0)
- MEMRI based NOD / scid-IL-2 R γ cnull mouse brain atlas for HIV pathobiology studies (2012) (0)
- Gordon, P. H. et al. Randomized controlled phase II trial of glatiramer acetate in ALS. Neurology 66, 1117-1119 (2006) (0)
- β-Amyloid priming and CD40L-mediated activation enhance cytokine and chemokine production in mononuclear phagocytes (2000) (0)
- LossofInfectivity byProgeny VirusfromAlphaInterferon- Treated HumanImmunodeficiency VirusType1-Infected T Cells IsAssociated withDefective Assembly ofEnvelope gpl20 (1992) (0)
- P-D8 Macrophage exosomes as novel antiretroviral drug delivery platforms (2017) (0)
- Model of NeuroAIDS Antiretroviral Drug to the Brain in a Murine Macrophage Delivery of Nanoformulated (2009) (0)
- Opposing regulation of endolysosomal pathways by long-acting nanoformulated antiretroviral therapy and HIV-1 in human macrophages (2015) (0)
- Endosomal Trafficking of Nanoformulated Antiretroviral Therapy 2 (2014) (0)
- Medicinal Chemistry and Brain Drug Penetrance (2017) (0)
- Erratum: Proteomic analyses of monocytes obtained from Hispanic women with HIV‐associated dementia show depressed antioxidants (2010) (0)
- P-A8 Establishing tissue reservoirs for the human immunodeficiency virus in humanized mice (2018) (0)
- URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease (2018) (0)
- In Appreciation for a Job Well Done! (2019) (0)
- Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders? (2012) (0)
- Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium (2014) (0)
- P-D9 Development of a Next Generation Long-Acting Nanoformulated Cabotegravir (2017) (0)
- Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice (2019) (0)
- CPDD SYMPOSIUM ON HIV IN THE BRAIN (1997) (0)
- Pathways for Dolutegravir Transformation from a Daily Oral to a Once-a-Year Parenteral Medicine (2022) (0)
- An interactive cluster heat map to visualize and explore multidimensional metabolomic data (2014) (0)
- Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice (2015) (0)
- Manganese-enhanced magnetic resonance imaging detects VIPR2-mediated immune transformation in a model of Parkinson’s disease (2016) (0)
- Murine Model of Viral Encephalitis HIV-1-Infected Macrophages: Studies in a Immune-Mediated Elimination of Neuroregulatory Events Follow Adaptive (2004) (0)
- a Murine Model of HIV-1 Encephalitis Virus-Infected Human Brain Macrophages in Generation of Cytotoxic T Cells Against (2013) (0)
- SARS-CoV-2 Infection Leads to Neurological Dysfunction (2020) (0)
- Human Immunodeficiency Virus Type 1 Pathobiology Studied in Humanized BALB/c-Rag2-/- Î3c-/- Mice (2019) (0)
- Club drugs and HIV transmission. (2005) (0)
- Erratum (2017) (0)
- CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice. (2023) (0)
- Murine Motor and Behavior Functional Evaluations for Acute 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Intoxication (2011) (0)
- Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease (2018) (0)
- Central nervous system neoplasms in AIDS. (2005) (0)
- P-D2 Macrophage Autophagy Facilitates Sustained Release of Nanoformulated Antiretroviral Drugs From Autophagosomal Depots Enhances Anti-HIV-1 Activities (2017) (0)
- Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease (2016) (0)
- Change in Evolution (2012) (0)
- Spinal cord disease: clinical presentations and pathology. (2005) (0)
- Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes (2014) (0)
- Reply (1994) (0)
- The promise of nanoneuromedicine: An editorial (2016) (0)
- Immune competent macrophages produce neurotrophic factors (2000) (0)
- Development of a porous layer-by-layer microsphere with branched aliphatic hydrocarbon porogens. (2022) (0)
- 3.14.4 IMMUNIZATION STRATEGIES IN PD (2012) (0)
- Treatment of opportunistic infections associated with HIV infection. (2005) (0)
- The Potential for Treg-Enhancing Therapies in Nervous System Pathologies. (2022) (0)
- Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice (2018) (0)
- P-D7 Synthesis and Characterization of a Long Acting Nanoformulated Dolutegravir (2017) (0)
- New insights into the neuropathogenesis of HIV-1 disease (1994) (0)
- Particle Carriage and HIV Clearance Antiretroviral Therapy Facilitates Drug Endosomal Trafficking of Nanoformulated (2014) (0)
- Introducing NeuroImmune Pharmacology and Therapeutics (NIPT), the official journal of the Society on NeuroImmune Pharmacology (SNIP) (2022) (0)
- Neurobiology and Neural Systems (2008) (0)
- Inhibition of matrix metalloproteinases by HIV-1 integrase strand transfer inhibitors (2023) (0)
- Plasma Levels of Soluble CD14 and Tumor Necrosis Factor– a Type II Receptor Correlate with Cognitive Dysfunction during Human Immunodeficiency Virus Type 1 Infection (2001) (0)
- Dual-Peak Lorentzian CEST MRI for antiretroviral drug brain distribution (2022) (0)
- D-110 Synergism between CRISPR/Cas9 and LASER ART leads to elimination of HIV-1 with no rebound in Humanized Mice (2018) (0)
- Alzheimer’s disease brain-derived tau-containing extracellular vesicles: Pathobiology and GABAergic neuronal transmission (2020) (0)
- Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice (2014) (0)
- NEBR1: A novel mononuclear phagocyte transcriptional factor that links divergent neurodegenerative disorders (2000) (0)
- Disseminating Research Discovery Through an Interactive Video: a Paradigm Shift for Journal Publication (2008) (0)
- MOLECULAR AND OMICS-BASED ANALYSES ATRANSCRIPTOMIC LANDSCAPE OF MICROGLIAL ACTIVATION IN ALZHEIMER’S DISEASE (2018) (0)
- Thank You! (2017) (0)
- EFAVIRENZ, ATAZANAVIR AND RITONAVIR IMPAIR SARCO(ENDO)PLASMIC RETICULUM Ca2+ CYCLING (2013) (0)
- Enhancement of NMDA Receptor-Mediated Excitatory Postsynaptic Currents by gp120-Treated Macrophages: Implications for HIV-1-Associated Neuropathology (2013) (0)
- 2and Adaptive Immunity in Health and Disease (2008) (0)
- Neurological disease produced by maedi-visna and caprine arthritis-encephalitis viruses, lentiviruses of sheep and goats. (2005) (0)
- HIV-1-Infected Macrophage Giant Cells Cytoskeletal Protein Transformation in (2007) (0)
- Humanized Mice as a Platform for the Development of Long-Acting Nanoformulated Antiretroviral Therapy (2014) (0)
- A Role for Extracellular Vesicles in SARS-CoV-2 Therapeutics and Prevention (2021) (0)
- Overview of Mononuclear Phagocytes (2017) (0)
- The genetic bases of HIV-1 neuropathogenesis. (2005) (0)
- Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients (2013) (0)
- Book Review HIV and the Pathogenesis of AIDS By Jay A. Levy. 359 pp., illustrated. Washington, D.C., ASM Press, 1994. $49. 1-55581-076-4 (1995) (0)
- Immunopathology in Humanized Mice Cell Depletion Accelerates HIV-1 + CD8 (0)
- Improved Visualization of Neuronal Injury Following Glial Activation by Manganese Enhanced MRI (2013) (0)
- The First Insubria Autumn School on Neuroimmunopharmacology: Challenging Paradigms Beyond Boundaries (2013) (0)
- CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease (2012) (0)
- Human Dendritic Cells Transduced with Herpes Simplex Virus Amplicons Encoding Human Immunodeficiency Virus Type 1 (HIV-1) gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Chal (2019) (0)
- An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression (2022) (0)
- Facing legal and ethical challenges in the treatment of AIDS. (2005) (0)
- Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages (2019) (0)
- HIV Dementia: A Patient’s Perspective Living with the Suffering, the Diagnosis, and the Uncertainties (2011) (0)
- Coping, methamphetamine, and HIV. (2005) (0)
- HIV-1 Encephalitis is a Consequence of Viral Infection and Neuroimmune Activation (1996) (0)
- Disparate Neuronal and Glial Signal Enhancement in MEMRI (2011) (0)
- "While biomaterials, sensors, nanoparticles, and nanospheres are potential platforms for drug and gene delivery for nanoneuromedicines, few are fully developed for human use, and each hold a number of challenges." (2014) (0)
- Produce Neurotoxic Levels of l-Cysteine Human Monocyte-Derived Macrophages Cytokine-Stimulated, But Not HIV-Infected, (2000) (0)
- CD4+ T cell effector activities accelerate Alzheimer’s disease pathologies (2021) (0)
- I-106 Special lecture: Transforming anti-HIV drugs (2017) (0)
- DiseaseNeurodegeneration in a Model of Parkinson's Cell-Mediated Nigrostriatal Dopaminergic Regulatory T Cells Attenuate Th17 (2010) (0)
- HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication (2018) (0)
- Running title: Macrophage-based anti-retroviral therapy (2013) (0)
- Opendra “Bill” Narayan (1936–2007): A Personal Tribute to a Friend, Teacher, and Colleague (2008) (0)
- Cytokine and viral gene expression during infection of monocytes by the human immunodeficiency virus: central role of interferons in the promotion and resolution of virus infection (1992) (0)
- Tribute to Bill Narayan (2008) (0)
- The presence of HIV in SCID MICE with HIV encephalitis correlates with gliosis (1996) (0)
- HIV-1 dementia: A metabolic encephalopathy abrogated by highly active antiretroviral therapy (HAART) (1997) (0)
- The Journal of Neuroimmune Pharmacology Reaches Its Stride (2007) (0)
- Change in Evolution (2012) (0)
- HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice (2020) (0)
- P-D4 Evaluation of Combination Long-Acting Nanoformulated Antiretroviral Therapy in HIV-1 Infected huPBL NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ MICE (2017) (0)
- Antiretroviral Transcriptional Factor , Molecular Characterization of a Putative Gendelman and Tsuneya (2003) (0)
- Methamphetamine-Associated Psychosis (2011) (0)
- Generation and Disease Model Relevance of a Manganese Enhanced Magnetic Resonance Imaging-Based NOD/scid-IL-2Rγcnull Mouse Brain Atlas (2015) (0)
- Creation of a long-acting nanoformulated dolutegravir (2018) (0)
- Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection (2013) (0)
- Neuroimmune cross talk and HIV-associated neurocognitive disorders (2013) (0)
- P-A9 Transformation of Darunavir into a long acting nanoformulated prodrug (2018) (0)
- Animal Model Human Immunodeficiency Virus Encephalitis in SCID Mice (2007) (0)
- A Welcome Message from the Editor-in-Chief (2006) (0)
- Mononuclear Phagocyte Inflammation and Neurotoxicity (2011) (0)
- Humanized Mice for Infectious and Neurodegenerative disorders (2021) (0)
- CD4+ effector T cells accelerate Alzheimer’s disease in mice (2021) (0)
- Resource Brain Region Mapping Using Global Metabolomics (2014) (0)
- Commentary: Animal Models of NeuroAIDS (2012) (0)
- Human Immunodeficiency Virus Type 1 Pathobiology Studied in Humanized BALB / cRag 2 / c / Mice (2017) (0)
- Thank You! (2017) (0)
- "Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination" data files (2021) (0)
- Responses in a Murine Model of HIV-1 Neuroprotective Anti-inflammatory Glial and Copolymer-1 Induces Adaptive Immune (2014) (0)
- Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination (2021) (0)
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