Howard J. Federoff
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Why Is Howard J. Federoff Influential?
(Suggest an Edit or Addition)Howard J. Federoff's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor (2002) (1803)
- Plasma phospholipids identify antecedent memory impairment in older adults (2014) (862)
- PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease (2010) (699)
- Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study (2015) (579)
- Regulation of Neuronal Traits by a Novel Transcriptional Complex (2001) (434)
- Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss (1999) (420)
- Synuclein activates microglia in a model of Parkinson's disease (2008) (414)
- Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons (1996) (344)
- Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. (1995) (296)
- Nerve growth factor administration protects against experimental diabetic sensory neuropathy (1994) (288)
- Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death (2004) (287)
- Behavioral and Neurochemical Effects of Wild-Type and Mutated Human α-Synuclein in Transgenic Mice (2002) (274)
- A focus on the synapse for neuroprotection in Alzheimer disease and other dementias (2004) (268)
- Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins (2001) (246)
- Nerve Growth Factor Prevents Both Neuroretinal Programmed Cell Death and Capillary Pathology in Experimental Diabetes (1995) (245)
- Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice (2005) (229)
- Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease (2017) (220)
- Hypoxia-Inducible Factor-1α Mediates Hypoxia-Induced Delayed Neuronal Death That Involves p53 (1999) (200)
- Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia. (1992) (197)
- Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. (2008) (187)
- GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system. (1989) (177)
- Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi‐mutated herpes simplex virus type‐1 (G207) (1999) (176)
- Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea. (1990) (176)
- Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss (1998) (174)
- Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study (2015) (172)
- Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids. (1988) (172)
- Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (170)
- Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease (2010) (163)
- Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors (2002) (163)
- Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein (2012) (152)
- The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1α in Neurons and Astrocytes (2008) (150)
- HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. (2009) (147)
- Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. (1995) (142)
- Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. (2002) (140)
- Blockade of Gap Junctions In Vivo Provides Neuroprotection After Perinatal Global Ischemia (2005) (131)
- Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. (2004) (129)
- Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity (2009) (128)
- The critical need for defining preclinical biomarkers in Alzheimer's disease (2014) (124)
- Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? (2005) (123)
- HIF-1α and p53 Promote Hypoxia-Induced Delayed Neuronal Death in Models of CNS Ischemia (1999) (122)
- Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. (2011) (122)
- A genome-wide association study in multiple system atrophy (2016) (122)
- Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements (1999) (115)
- Regeneration of the MPTP-Lesioned Dopaminergic System after Convection-Enhanced Delivery of AAV2-GDNF (2010) (109)
- Current Treatment for Alzheimer Disease and Future Prospects (2003) (108)
- Evolving from reductionism to holism: is there a future for systems medicine? (2009) (104)
- Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. (2002) (103)
- Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. (1996) (103)
- Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. (2009) (102)
- Dysregulation of Gene Expression in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Substantia Nigra (2004) (101)
- Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer (2001) (101)
- Real-time MR imaging of adeno-associated viral vector delivery to the primate brain (2009) (99)
- Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease (2019) (98)
- Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing (2003) (98)
- Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer (2002) (95)
- Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease (2006) (95)
- Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. (1993) (91)
- Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. (1996) (90)
- BCL-2 Transduction, Using a Herpes Simplex Virus Amplicon, Protects Hippocampal Neurons from Transient Global Ischemia (1999) (89)
- Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). (1999) (89)
- Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. (2009) (88)
- PGC−1α Promoter Methylation in Parkinson’s Disease (2015) (88)
- p75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid β Peptide Cytotoxicity (2003) (86)
- Immune Responses in Parkinson's Disease: Interplay between Central and Peripheral Immune Systems (2014) (85)
- HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport (2009) (84)
- Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. (2008) (83)
- Topical application of viral vectors for epidermal gene transfer. (1997) (82)
- Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. (2009) (81)
- HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. (2001) (81)
- Intravesical oncolytic viral therapy using attenuated, replication‐competent, herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model (2001) (81)
- Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. (1995) (78)
- An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies (2010) (78)
- Effective treatment of pancreatic tumors with two multimutated herpes simplex oncolytic viruses (2000) (77)
- Precision pharmacology for Alzheimer's disease. (2018) (74)
- Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons (2006) (73)
- Reporter gene transfer induces apoptosis in primary cortical neurons. (2002) (72)
- Estrogenic regulation and sex dimorphism of growth-associated protein 43 kDa (GAP-43) messenger RNA in the rat. (1991) (72)
- A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. (2001) (70)
- α‐Synuclein mediates alterations in membrane conductance: a potential role for α‐synuclein oligomers in cell vulnerability (2010) (70)
- Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints (2018) (69)
- Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. (2003) (67)
- The Endoplasmic Reticulum Stress Response Factor CHOP-10 Protects against Hypoxia-induced Neuronal Death (2010) (66)
- Nonenzymatic Glycosylation of Laminin and the Laminin Peptide CIKVAVS Inhibits Neurite Outgrowth (1993) (66)
- Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional ‘detour’ in the hemisected spinal cord (2011) (65)
- CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. (2008) (65)
- Expression of the bcl-2 Gene from a Defective HSV-1 Amplicon Vector Protects Pancreatic β-Cells from Apoptosis (1996) (64)
- Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. (2001) (63)
- What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease (2017) (62)
- HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury (2003) (62)
- Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. (1994) (61)
- Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. (1995) (61)
- Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease (2015) (60)
- Trk retrograde signaling requires persistent, Pincher-directed endosomes (2010) (60)
- Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. (2006) (58)
- Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media (2018) (57)
- Trial of magnetic resonance–guided putaminal gene therapy for advanced Parkinson's disease (2019) (56)
- Convergent Pathobiologic Model of Parkinson's Disease (2003) (56)
- Expression of Human Immunodeficiency Virus Type 1 gp120 from Herpes Simplex Virus Type 1-Derived Amplicons Results in Potent, Specific, and Durable Cellular and Humoral Immune Responses (2002) (55)
- Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. (2001) (53)
- Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. (2000) (53)
- Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer (2000) (52)
- Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain. (1993) (51)
- Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. (1999) (50)
- Overexpression of GluR6 in Rat Hippocampus Produces Seizures and Spontaneous Nonsynaptic Bursting in Vitro (2000) (49)
- Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. (2010) (48)
- Metabolomic biomarkers of pancreatic cancer: a meta-analysis study (2017) (48)
- VIP is a transcriptional target of Nurr1 in dopaminergic cells (2007) (47)
- Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4. (2008) (47)
- Activity-dependent α-Cleavage of Nectin-1 Is Mediated by A Disintegrin and Metalloprotease 10 (ADAM10)* (2010) (47)
- Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production. (1996) (46)
- Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models. (2017) (46)
- Human Dendritic Cells Transduced with Herpes Simplex Virus Amplicons Encoding Human Immunodeficiency Virus Type 1 (HIV-1) gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Challenge (2005) (45)
- GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop (2020) (45)
- The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. (2004) (44)
- Wild-type and mutant α-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD (2007) (44)
- Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy (2003) (44)
- Neurotrophin secretory pathways and synaptic plasticity (2003) (44)
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. (2016) (43)
- Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection (2003) (43)
- Association of cerebrospinal fluid α-synuclein with total and phospho-tau181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers (2018) (43)
- Functional Interaction between Fluorodeoxyuridine-Induced Cellular Alterations and Replication of a Ribonucleotide Reductase-Negative Herpes Simplex Virus (2001) (43)
- Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations (2012) (43)
- Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial (2015) (43)
- Gene Therapeutic Strategies for Neuroprotection: Implications for Parkinson's Disease (1997) (42)
- Enhanced Vascularization and Survival of Neural Transplants with Ex Vivo Angiogenic Gene Transfer (2002) (41)
- Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon. (1997) (41)
- Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease (2019) (38)
- Cloning and Characterization of the Rat Gene Encoding GAP‐43 (1990) (38)
- Temporal and spatial localization of nectin‐1 and l‐afadin during synaptogenesis in hippocampal neurons (2008) (38)
- Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases (2012) (38)
- Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector (1998) (38)
- Altered Gene Expression Profiles Reveal Similarities and Differences Between Parkinson Disease and Model Systems (2005) (38)
- HSV amplicon-mediated Aβ vaccination in Tg2576 mice: differential antigen-specific immune responses (2005) (37)
- Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson’s disease (2010) (37)
- Immunotherapeutic Approaches for Alzheimer’s Disease (2016) (37)
- Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness. (1994) (36)
- Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. (2004) (36)
- Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of ere recombinase (1997) (35)
- Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis (2007) (35)
- Single-Chain Fragment Variable Passive Immunotherapies for Neurodegenerative Diseases (2013) (35)
- Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. (2002) (34)
- Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat (2006) (34)
- Gene Therapy in the Inner Ear: Mechanisms and Clinical Implications (1999) (33)
- Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. (2009) (33)
- Rapid and efficient gene transfer in human hepatocytes by herpes viral vectors (1995) (33)
- Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia (1995) (33)
- beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. (2005) (33)
- Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. (1996) (32)
- Loss of c/EBP-β activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons (2008) (32)
- Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency (2008) (31)
- Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. (2000) (30)
- HSV vector-mediated gene delivery to the central nervous system. (2001) (30)
- A Neurotoxic Phosphoform of Elk-1 Associates with Inclusions from Multiple Neurodegenerative Diseases (2010) (29)
- Combination Vascular Delivery of Herpes Simplex Oncolytic Viruses and Amplicon Mediated Cytokine Gene Transfer Is Effective Therapy for Experimental Liver Cancer (2001) (29)
- Identification of human α-synuclein specific single chain antibodies (2006) (29)
- Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. (2000) (29)
- Genomics and bioinformatics of Parkinson's disease. (2012) (29)
- Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. (2007) (29)
- Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. (1998) (28)
- Efficacy of Multiagent Herpes Simplex Virus Amplicon-Mediated Immunotherapy as Adjuvant Treatment for Experimental Hepatic Cancer (2002) (28)
- Membrane palmitoylated proteins regulate trafficking and processing of nectins. (2011) (27)
- Systems healthcare: a holistic paradigm for tomorrow (2017) (27)
- Gene therapeutic strategies for neurodegenerative diseases (2005) (26)
- Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium (2008) (26)
- Functional characterization of the rat GAP-43 promoter (1994) (26)
- Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform (2010) (26)
- Utilizing Tumor Hypoxia to Enhance Oncolytic Viral Therapy in Colorectal Metastases (2004) (26)
- Personality and Performance in Specific Neurocognitive Domains Among Older Persons. (2017) (26)
- Ectodomain shedding of nectin‐1 regulates the maintenance of dendritic spine density (2012) (25)
- Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice. (1994) (25)
- Microarrays in Parkinson’s disease: A systematic approach (2006) (25)
- Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. (2008) (24)
- Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. (2002) (24)
- Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices (1993) (24)
- Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls (2018) (24)
- In Cultured Astrocytes, p53 and MDM2 Do Not Alter Hypoxia-inducible Factor-1α Function Regardless of the Presence of DNA Damage* (2007) (22)
- Repeated Acquisition and Performance Chamber for Mice: A Paradigm for Assessment of Spatial Learning and Memory (2000) (22)
- Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. (2007) (22)
- Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. (2000) (22)
- Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector. (1995) (21)
- Parkinson's disease : the life cycle of the dopamine neuron (2003) (21)
- Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity (1999) (20)
- Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. (2003) (20)
- Identification of human alpha-synuclein specific single chain antibodies. (2006) (20)
- Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. (2009) (20)
- HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. (2002) (20)
- Temporal evolution of mouse striatal gene expression following MPTP injury (2005) (19)
- In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors (1999) (19)
- Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. (2007) (18)
- Evaluation of an AAV2-Based Rapamycin-Regulated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Vector System (2011) (18)
- Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. (2003) (18)
- Translational considerations for CNS gene therapy (2007) (17)
- Plasma microRNA markers of upper limb recovery following human stroke (2018) (17)
- Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. (2001) (17)
- Potential Metabolomic Linkage in Blood between Parkinson’s Disease and Traumatic Brain Injury (2018) (17)
- Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD (2019) (16)
- Herpes Simplex Virus Amplicon Delivery of a Hypoxia-Inducible Soluble Vascular Endothelial Growth Factor Receptor (sFlk-1) Inhibits Angiogenesis and Tumor Growth in Pancreatic Adenocarcinoma (2005) (16)
- Characterization of nectin processing mediated by presenilin‐dependent gamma‐secretase (2011) (16)
- Therapeutic potential of vaccines for Alzheimer's disease. (2011) (15)
- Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. (1997) (15)
- Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. (2007) (15)
- Efficient cotransduction of tumors by multiple herpes simplex vectors: Implications for tumor vaccine production (2000) (15)
- Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus‐1 vector (1995) (15)
- Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development. (2018) (14)
- Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. (2007) (14)
- Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. (2001) (14)
- Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. (1998) (14)
- Expression of Neurotrophic Genes from Herpes Simplex Virus Type 1 Vectors: Modifying Neuronal Phenotype (1994) (14)
- Safety of viral vectors for neurological gene therapies. (2004) (14)
- Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice. (2010) (14)
- Novel targets for CNS gene therapy (1999) (13)
- A rough morphology of the adsorbed fibronectin layer favors adhesion of neuronal cells. (2008) (13)
- Amyloid immunotherapy-engendered CNS inflammation (2002) (13)
- Gene delivery to the nervous system. (2008) (13)
- Somatic gene transfer approaches to manipulate neural networks (1997) (13)
- Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. (2014) (13)
- Perspectives on best practices for gene therapy programs. (2015) (13)
- Gazing into the future: Parkinson's disease gene therapeutics to modify natural history (2008) (12)
- A Community-Based Study Identifying Metabolic Biomarkers of Mild Cognitive Impairment and Alzheimer's Disease Using Artificial Intelligence and Machine Learning. (2020) (12)
- Clinically relevant effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged Rhesus monkeys (2009) (12)
- Immune responses to herpesviral vectors. (2009) (12)
- CNS Gene Therapy and a Nexus of Complexity: Systems and Biology at a Crossroads (2006) (12)
- Development of vaccination approaches for the treatment of neurological diseases (2009) (12)
- Using viral-mediated gene delivery to model Parkinson's disease: Do nonhuman primate investigations expand our understanding? (2014) (12)
- MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints (2021) (11)
- Nur(R1)turing a Notion on the Etiopathogenesis of Parkinson’s Disease (2009) (11)
- Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. (2003) (11)
- The use of hsv 1 vectors to introduce heterologous genes into neurons implications for gene therapy (1991) (11)
- Immune-Directed Gene Therapeutic Development for Alzheimer’s, Prion, and Parkinson’s Diseases (2009) (11)
- Identification of a Novel Nurr1-Interacting Protein (2008) (11)
- Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma (2004) (11)
- Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice. (1995) (10)
- HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. (2007) (10)
- G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro (1999) (10)
- Disclosure of Clinical Trial Results When Product Development Is Abandoned (2011) (10)
- Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers (2020) (10)
- Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival (2007) (10)
- Drug discovery dilemma and Cura quartet collaboration. (2009) (9)
- Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease (2022) (9)
- The Use of Defective Herpes Simplex Virus Amplicon Vectors to Modify Neural Cells and the Nervous System (1995) (9)
- HSV amplicons: neuro applications. (2006) (9)
- A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit (1995) (8)
- Gene Therapy for the Treatment of Parkinson’s Disease: The Nature of the Biologics Expands the Future Indications (2012) (8)
- Hexamethylene bisacetamide leads to reduced helper virus‐free HSV‐1 amplicon expression titers via suppression of ICP0 (2008) (8)
- PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics (2019) (7)
- Effects of herpes simplex virus amplicon transduction on murine dendritic cells. (2009) (7)
- Gene therapeutic approaches to the treatment of Parkinson's disease (2001) (7)
- Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption (1998) (7)
- Biomarker validation: Methods and matrix matter (2017) (7)
- Imaging and the aging brain (2007) (7)
- Alzheimer's Disease: Reducing the burden with ApoE2 (2005) (7)
- A new research and development policy framework for the biomedical research enterprise. (2010) (7)
- U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH RECOMBINANT DNA ADVISORY COMMITTEE Minutes of Meeting (2006) (6)
- Improved HSV‐1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity (2006) (6)
- Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. (1999) (6)
- 222. HSV Amplicon Expression of Single Chain Antibodies Directed Against |[alpha]|-Synuclein Conformers (2004) (6)
- Development of Inducible Leucine-rich Repeat Kinase 2 (LRRK2) Cell Lines for Therapeutics Development in Parkinson’s Disease (2013) (6)
- Effect of early-stage Alzheimer's disease on household financial outcomes. (2019) (5)
- Expression pattern of NuIP gene in adult mouse brain (2009) (5)
- Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype (2018) (5)
- Plasma Sphingomyelins in Late-Onset Alzheimer's Disease. (2021) (5)
- TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC (2021) (5)
- Humoral Immune Responses Potent , Specific , and Durable Cellular and Virus Type 1-Derived Amplicons Results in Virus Type 1 gp 120 from Herpes Simplex Expression of Human Immunodeficiency (2002) (4)
- Seeking progress in disease modification in Parkinson disease. (2021) (4)
- Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. (2008) (4)
- Research Article Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study (2014) (4)
- Immune shaping and the development of Alzheimer's disease vaccines. (2005) (4)
- A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease (2022) (4)
- Molecular p 75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid Peptide Cytotoxicity (2003) (4)
- PATHOGENIC PROTEINS IN NEURALLY-DERIVED BLOOD EXOSOMES AS NEAR-PERFECT DIAGNOSTIC AND PROGNOSTIC BIOMARKERS FOR ALZHEIMER'S DISEASE (2014) (4)
- Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction (2008) (4)
- Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. (2007) (3)
- Microglial activation in a mouse model of α-synuclein overexpression (2008) (3)
- Reversal of Misfolding: Prion Disease Behavioral and Physiological Impairments Recover following Postnatal Neuronal Deletion of the PrP Gene (2007) (3)
- Protect NIH's DNA advisory committee (2018) (3)
- Research report h-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration (2005) (3)
- Systems Biology: Unravelling Molecular Complexity in Health and Disease (2016) (3)
- Other clinical studyRapid and efficient gene transfer in human hepatocytes by herpes viral vectors (1995) (3)
- Systems Medicine: A New Model for Health Care (2013) (3)
- An infectious conspiracy: the case for HSV-1 and APOEϵ4 in Alzheimer’s disease (1999) (3)
- The role of HSV amplicon vectors in cancer gene therapy (2000) (2)
- 552. Single-Chain Antibodies for Viral-Based Passive Immuno-Therapy for Prion Disease: Linear Epitope Mapping and Clearance from Thalamic Injection (2004) (2)
- An infectious conspiracy: the case for HSV-1 and APOEepsilon4 in Alzheimer's disease. (1999) (2)
- Modules, networks and systems medicine for understanding disease and aiding diagnosis (2014) (2)
- Herpes Simplex Viral Vector Gene-Based Therapy to Prevent Loss of Auditory Sensory Cells from Stress-Induced Apoptosis (2000) (2)
- The Changing Spectrum of Biomedical and Clinical Research (2015) (2)
- Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism. (2005) (2)
- The evolution of gene transfer, gene therapy, and the RAC: IOM recommendations to the NIH director. (2014) (2)
- Chapter 34 Towards gene therapy of neurodegenerative disease (1998) (2)
- CNS diseases amenable to gene therapy. (2003) (2)
- Social media communications networks and pharmacovigilance: SequelAE-2.0 (2013) (1)
- Gene Therapy for Neurological Diseases (2003) (1)
- Repairing the Parkinson Brain. (2021) (1)
- Article Commentary: Technology and Innovation: 2010 a Year in Review (2011) (1)
- Development of Nurr1 Stable Cell Lines for the Identification of Downstream Targets (2003) (1)
- Parkinson's disease gene therapy: GAD Zooks! Excitement to inhibition in one easy step? (2003) (1)
- Novel gene therapeutic strategies for neurodegenerative diseases. (2005) (1)
- 2016 Plasma microRNA markers of upper limb recovery following human stroke (2018) (1)
- ANNOUNCING THE INAUGURAL ISSUE OF TECHNOLOGY AND INNOVATION (FORMERLY TECHNOLOGY ) (2010) (1)
- Responding to Change: The Business of Research (2010) (0)
- Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease (2022) (0)
- EXOME SEQUENCING AS A RAPID AND COST EFFICIENT DIAGNOSTIC METHOD IN NEUROGENETIC DISORDERS (2011) (0)
- Mammalian gap-43 composition and its use (1990) (0)
- P-096 Regulation of neuroprotective proteins BCL2 and GSK3 in leukocytes from valproate-treated patients with Alzheimer’s disease (2007) (0)
- Expression ofnervegrowthfactor invivofromadefective herpes simplex virus 1vector prevents effects ofaxotomy on sympathetic ganglia (1992) (0)
- P3.190 The role of early oxidative stress events in Parkinson's disease (2009) (0)
- E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury (2022) (0)
- Effects of HSV amplicon transduction on murine dendritic cells (2009) (0)
- 248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model* (2006) (0)
- Human Dendritic Cells Transduced with Herpes Simplex Virus Amplicons Encoding Human Immunodeficiency Virus Type 1 (HIV-1) gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Chal (2019) (0)
- Regulation of TLR Signaling by USP7. (2007) (0)
- Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study (2020) (0)
- Textbook of Gene Therapy (2000) (0)
- Correction: Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study (2022) (0)
- 247. Devising Aβ-Specific Passive Immunization Strategies for Alzheimer's Disease Using rAAV Vector-Mediated scFv Antibody Delivery (2006) (0)
- Somatic mosaic approaches and the aging brain (2002) (0)
- 1992 referees (2004) (0)
- Multidisciplinary Approaches to Biomedical Research. Authors' reply (2010) (0)
- P4-340 Immunological assessment of acute CNS inflammatory processes elicited in an Alzheimer's disease mouse model following HSV amplicon-based Aβ vaccination (2004) (0)
- JAMA Neurology Peer Reviewers in 2016. (2017) (0)
- NATIONAL INSTITUTES OF HEALTH RECOMBINANT DNA ADVISORY COMMITTEE (RAC) 107th Meeting NIH Campus (2006) (0)
- Helper-Free Herpes Simplex Virus Amplicons allow Efficient Transduction of Leukemia Cells with a costimulatory ligand without Loss of MHC-I Expression (1999) (0)
- PU-91, a mitochondria-stabilizing drug, rescues AMD ARPE-19 cybrid cells; implications for macular degeneration therapeutics (2018) (0)
- Adoptively transferred tumor-specific T cells expanded ex vivo using HSV amplicons encoding 4-1BBL persist in the host and demonstrate anti-tumor activity in vivo. (88.11) (2007) (0)
- 226. Developing a CNS-Specific Inflammatory Model To Investigate Gene Therapy/Inflammation Interactions in the Context of Neurodegeneration|[ast]| (2004) (0)
- INTRODUCTION: NEW INSIGHTS INTO LONG-STANDING ISSUES (2016) (0)
- Carotid body dysfunction and altered oxygen homeostasis in models of Parkinson's disease (2008) (0)
- Chapter 2 Systems Biology : Unravelling Molecular Complexity in Health and Disease (2019) (0)
- Neurobiology of Disease Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal (2004) (0)
- RNAi Mediated Silencing of LRRK2G2019S in Parkinson's Disease (2013) (0)
- PGC-1a Therapy for Parkinson Neurodegeneration (2015) (0)
- HSV ICP0 Inhibits TLR-Mediated NF-κB Response to TLR Signaling. (2006) (0)
- Potential of Nurr1 interactions to disclose new Parkinson’s therapeutics (2009) (0)
- Sam Seifter Reflections (2016) (0)
- Towards gene therapy of neurodegenerative disease. (1998) (0)
- TECHNOLOGY AND INVENTION. (2012) (0)
- Author Correction: Plasma microRNA markers of upper limb recovery following human stroke (2020) (0)
- Multidisciplinary Approaches to Biomedical Research—Reply (2010) (0)
- Alterations in myocardial β-adrenoceptor subtypes and signal transduction pathway in nerve growth factor overexpressing transgenic mice (1998) (0)
- Molecular Modification of Neural Networks: Altering Synaptic Function Through the use of Viral Mediated Gene Transfer (1997) (0)
- Stimulation of neurite growth rat adrenal chromaffin cells infected with a defective herpes simplex virus carrying an NGF minigene. (1994) (0)
- Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study (2019) (0)
- Contributors to Volume 21 (1994) (0)
- Correction: Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study (2022) (0)
- HSV Amplicon Transduction Activates an Innate Immune Response in CLL B Cells;Implications for Immune Therapy and Vaccine Development. (2004) (0)
- Framework design and development of an informatics architecture for a systems biology approach to traumatic brain injury (2010) (0)
- 966. AAV Delivered Single-Chain Antibodies as Passive Immuno-Therapy for Prion Disease (2005) (0)
- Gene Transfer to the Nervous System: Status and Promise for Therapy (2001) (0)
- Effective treatment of pancreatic tumors withtwo multimutated herpes simplex oncolytic viruses (2000) (0)
- Microarrays in Parkinson' sD isease: A Systematic Approach (2006) (0)
- 43. Immunological Response Characterization in an Alzheimer's Disease Mouse Model Following HSV Amplicon-Based A|[beta]| Vaccination|[ast]| (2004) (0)
- Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson’s Disease (2022) (0)
- SDF-1 MEDIATED IMMUNE EFFECTOR CELL RECRUITMENT USING HSV AMPLICON VECTORS (1999) (0)
- P3-325 Nectin-1: intramembranous proteolytic processing and reduction in AD brain (2004) (0)
- Differential responses of AMD mitochondrial DNA haplogroups to PU-91, a mitochondria-targeting drug. (2021) (0)
- Preface (2003) (0)
- Orthodontic Faculty Development Award, 2001 FINAL REPORT (2001) (0)
- HSV Encoded ICP-0 Inhibits TLR Signaling in CLL Cells by Targeting TRAF-6. (2005) (0)
- A Plasma-based Biomarker Panel Identifies Preclinical Alzheimer's Disease (S38.001) (2014) (0)
- Application to Gene Therapy and Vaccination (2017) (0)
- Death in a gene-therapy trial. (2009) (0)
- EDITORIAL: PREFACE TO THE SPECIAL SECTION (2012) (0)
- Author Correction: Plasma microRNA markers of upper limb recovery following human stroke (2020) (0)
- chronic lymphocytic leukemia based immunotherapy for - Development of herpes simplex virus-1 amplicon (2013) (0)
- PGC−1α Methylation: Molecular Links between Fat Metabolism, Mitochondrial Regulation and Parkinson's Disease (P05.060) (2013) (0)
- P3-259 Expression of pathogenic tau, P301L, leads to microtubule disruption in hippocampal neurons (2004) (0)
- Blood-based metabolomic biomarkers for human neurological disorders (2017) (0)
- HSV Amplicon Vectors in Neuronal Apoptosis Studies (2002) (0)
- Abstract 2517: Prognostic biomarkers of PDAC - a cross-validation study (2017) (0)
- β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification (2020) (0)
- EDITORIAL: THE INAUGURAL CONFERENCE OF THE NATIONAL ACADEMY OF INVENTORS (2012) (0)
- Gene Therapy for Neurological Disorders and Brain Tumors (1999) (0)
- Title Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer ' s disease (2015) (0)
- AD Vaccination using HSV amplicons (2005) (0)
- Genetic modification of rat RPE cells using herpes and adenoviral vectors (1996) (0)
- Can population genomics guide future therapeutic gene transfer strategies for Parkinson’s disease? (2013) (0)
- Development of Inducible Leucine-rich Repeat Kinase 2 (LRRK2) Cell Lines for Therapeutics Development in Parkinson’s Disease (2013) (0)
- Developing Gene-Based Neuroprotection Strategies Using Herpes Amplicon Vectors (2002) (0)
- Editorial Board (2007) (0)
- Gene Therapy and Vaccination (2008) (0)
- Blood biomarkers in preclinical Alzheimer Disease (2016) (0)
- Helper virus-free herpesvirus-amplifikatpartikel and their uses (2001) (0)
- Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein (2012) (0)
- EDITORIAL: TECHNOLOGY, INNOVATION, AND HEALTH. (2012) (0)
- Development and Application of Single Chain Antibodies for PD Therapy (2003) (0)
- Blood Biomarkers of Cognitive Health and Neurodegenerative Disease (2020) (0)
- 211. Creation of a HSV VP22-Sleeping Beauty Fusion Protein To Facilitate Integration of HSV-1 Amplicon Vectors|[ast]| (2004) (0)
- Network modeling to identify new mechanisms and therapeutic targets for Parkinson’s disease (2013) (0)
- Georgetown University School of Medicine. (2010) (0)
- Xenomitochondrial mouse modeling update (2006) (0)
- Microarrays in Parkinson’s disease: A systematic approach (2006) (0)
- Attenuated HSV-1 kills human pancreatic cancer cells in vitro (1998) (0)
- 431. In Utero CNS Delivery of an Integrating HSV-1 Amplicon Vector Leads to Prolonged, Neuron-Specific Gene Expression (2005) (0)
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