Howard Schulman
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Computer Science
Howard Schulman's Degrees
- PhD Computer Science Stanford University
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(Suggest an Edit or Addition)Howard Schulman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The molecular basis of CaMKII function in synaptic and behavioural memory (2002) (1886)
- Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. (1998) (1323)
- Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. (1989) (1319)
- The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. (1995) (864)
- Interaction with the NMDA receptor locks CaMKII in an active conformation (2001) (701)
- Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. (2002) (644)
- Neuronal Ca2+/calmodulin-dependent protein kinases. (1992) (632)
- Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II. (2002) (612)
- Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase (1992) (577)
- Dual role of calmodulin in autophosphorylation of multifunctional cam kinase may underlie decoding of calcium signals (1994) (476)
- Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. (1991) (462)
- CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation (2005) (331)
- Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII (2003) (304)
- Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels* (2001) (292)
- Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein (1978) (288)
- Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator". (1978) (275)
- Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation (1989) (270)
- Nitric oxide stimulates Ca2+-independent synaptic vesicle release (1994) (266)
- The Cardiac-specific Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Induces Hypertrophy and Dilated Cardiomyopathy Associated with Increased Protein Phosphatase 2A Activity* (2002) (264)
- Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus (1994) (261)
- Nitric Oxide Modulates Synaptic Vesicle Docking/Fusion Reactions (1996) (256)
- Inhibitory autophosphorylation of multifunctional Ca2+/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis. (1992) (238)
- Transition from Reversible to Persistent Binding of CaMKII to Postsynaptic Sites and NR2B (2006) (232)
- The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C (1995) (229)
- KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. (1998) (228)
- The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes* (1997) (226)
- Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. (1987) (215)
- Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins (1994) (213)
- Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes. (1994) (205)
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme (2011) (202)
- Promiscuous protein biotinylation by Escherichia coli biotin protein ligase (2004) (198)
- The multifunctional Ca2+/calmodulin-dependent protein kinases. (1993) (191)
- Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. (2003) (188)
- An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling (2003) (182)
- Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase (1991) (181)
- Sphingosine inhibits calmodulin-dependent enzymes. (1988) (175)
- Phosphorylation of microtubule-associated proteins by a Ca2+/calmodulin- dependent protein kinase (1984) (175)
- CaMKII inhibitors: from research tools to therapeutic agents (2014) (173)
- Identification and characterization of δB-CaM kinase and δC-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms (1994) (169)
- Developmental and regional expression of multifunctional Ca2+/calmodulin-dependent protein kinase isoforms in rat brain (1995) (168)
- Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown (1990) (167)
- A Mechanism for Ca2+/Calmodulin-Dependent Protein Kinase II Clustering at Synaptic and Nonsynaptic Sites Based on Self-Association (2005) (166)
- Substrate-directed Function of Calmodulin in Autophosphorylation of Ca2+/Calmodulin-dependent Protein Kinase II* (1998) (162)
- Functional Implications of the Subunit Composition of Neuronal CaM Kinase II* (1999) (160)
- Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme. (1986) (160)
- A cAMP-regulated chloride channel in lymphocytes that is affected in cystic fibrosis. (1989) (160)
- CaM Kinase: Still Inspiring at 40 (2019) (150)
- Distinct autophosphorylation sites sequentially produce autonomy and inhibition of the multifunctional Ca2+/calmodulin-dependent protein kinase (1989) (147)
- An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation. (1994) (147)
- Regulation of Calcium/Calmodulin-dependent Protein Kinase II Docking toN-Methyl-d-aspartate Receptors by Calcium/Calmodulin and α-Actinin* (2002) (146)
- Developmental expression of the CaM kinase II isoforms: ubiquitous γ- and δ-CaM kinase II are the early isoforms and most abundant in the developing nervous system (1999) (143)
- Structural Examination of Autoregulation of Multifunctional Calcium/Calmodulin-dependent Protein Kinase II* (1999) (142)
- Calcium/Calmodulin-dependent Phosphorylation and Activation of Human Cdc25-C at the G2/M Phase Transition in HeLa Cells* (1999) (139)
- αKAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle (1998) (133)
- Cross-talk between protein kinase C and multifunctional Ca2+/calmodulin-dependent protein kinase. (1992) (124)
- Mechanism of autophosphorylation of the multifunctional Ca2+/calmodulin-dependent protein kinase. (1985) (123)
- Purification and characterization of a Ca2+/calmodulin-dependent protein kinase from rat brain. (1984) (121)
- Alternative splicing modulates the frequency‐dependent response of CaMKII to Ca2+ oscillations (2002) (119)
- lnterleukin-2 transcriptional block by multifunctional Ca2+/ calmodulin kinase (1994) (115)
- Regulation of signal transduction by protein targeting: the case for CaMKII. (2001) (113)
- Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation (2010) (113)
- Ca2+/Calmodulin-dependent Protein Kinase II Is Required for Microcystin-induced Apoptosis* (2002) (111)
- Multifunctional Ca2+/calmodulin-dependent protein kinase made Ca2+ independent for functional studies. (1990) (111)
- The role of Ca2+/calmodulin-dependent protein kinases within the nucleus. (1998) (109)
- Protein phosphorylation in neuronal plasticity and gene expression (1995) (108)
- Multifunctional Ca2+/calmodulin-dependent protein kinase: domain structure and regulation. (1989) (108)
- Decoding calcium signals by multifunctional CaM kinase. (1992) (106)
- Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. (2001) (97)
- Adenosine 3':5'-monophosphate receptor proteins in mammalian brain. (1978) (96)
- Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity (2013) (93)
- Developmental changes in Ca2+/calmodulin-dependent protein kinase II in cultures of hippocampal pyramidal neurons and astrocytes (1988) (90)
- Activation of multifunctional Ca2+/calmodulin-dependent kinase in intact hippocampal slices (1991) (85)
- A non‐selective cation current activated via the multifunctional Ca(2+)‐calmodulin‐dependent protein kinase in human epithelial cells. (1995) (85)
- Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system. (1999) (83)
- Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues. (1993) (82)
- Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Localization Acts in Concert with Substrate Targeting to Create Spatial Restriction for Phosphorylation* (2005) (81)
- Multifunctional Ca2+/calmodulin-dependent protein kinase (2004) (80)
- Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2(+)-independent in PC12 cells. (1990) (77)
- Molecular Characterization of Calmodulin Trapping by Calcium/Calmodulin-dependent Protein Kinase II* (2001) (75)
- Chemical Quenched Flow Kinetic Studies Indicate an Intraholoenzyme Autophosphorylation Mechanism for Ca2+/Calmodulin-dependent Protein Kinase II* (2002) (74)
- Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II (2016) (73)
- Activity-Dependent Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Localization (2004) (72)
- Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. (2013) (72)
- The multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca2+-dependent phosphorylation of tyrosine hydroxylase. (1988) (70)
- MECHANISM OF FONNATION AND STRUCTURE OF MICROEMULSIONS BY ELECTRON MICROSCOPY (1959) (68)
- Synaptic Plasticity: A molecular mechanism for metaplasticity (1995) (67)
- Identification of sn-glycero-1-phosphate and phosphoethanolamine residues linked to the membrane-derived Oligosaccharides of Escherichia coli. (1976) (62)
- Regulation of CI− channels by multifunctional CaM kinase (1991) (61)
- Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis. (2005) (60)
- Erratum: Molecular basis of calmodulin tethering and Ca 2+-dependent inactivation of L-type Ca2+ channels (Journal of Biological Chemistry (2001) 276 (30794-30802)) (2001) (60)
- Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents. (1992) (59)
- Localization of membrane-derived oligosaccharides in the outer envelope of Escherichia coli and their occurrence in other Gram-negative bacteria (1979) (56)
- Identification and characterization of delta B-CaM kinase and delta C-CaM kinase from rat heart, two new multifunctional Ca2+/calmodulin-dependent protein kinase isoforms. (1994) (56)
- Relation of turnover of membrane phospholipids to synthesis of membrane-derived oligosaccharides of Escherichia coli. (1977) (54)
- Acetylation and calcium-dependent phosphorylation of histone H3 in nuclei from butyrate-treated HeLa cells. (1983) (53)
- Activation of multifunctional Ca2+/calmodulin-dependent protein kinase in GH3 cells. (1991) (51)
- Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues. (1985) (50)
- Nitric oxide: a spatial second messenger (1997) (49)
- Calcium-dependent phosphorylation of histone H3 in butyrate-treated HeLa cells (1980) (48)
- β2‐Adrenergic Receptors on Peripheral Nerves (1986) (47)
- Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor. (2018) (46)
- Calcium Regulation of Exocytosis in PC12 Cells* (2001) (45)
- Hormone receptors on cloned T lymphocytes. Increased responsiveness to histamine, prostaglandins, and beta-adrenergic agents as a late stage event in T cell activation. (1988) (44)
- Calcium-Dependent Protein Phosphorylation (1982) (43)
- Neuroprotective effect of activity‐dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis‐linked mutant SOD1 in vitro and in vivo (2004) (42)
- Metabolism of Membrane Phospholipids and Its Relation to a Novel Class of Oligosaccharides in Escherichia coli (1973) (42)
- Evidence for the activation of the multifunctional Ca2+/calmodulin-dependent protein kinase in response to hormones that increase intracellular Ca2+. (1987) (41)
- Decoding Ca2+ signals to the nucleus by multifunctional CaM kinase. (1995) (38)
- New phosphoglucose isomerase mutants of Escherichia coli (1975) (38)
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme (2011) (35)
- Nitric oxide synthase expression in single hippocampal neurons. (1994) (34)
- CAM KINASE : A MODEL FOR ITS ACTIVATION AND DYNAMICS (1994) (33)
- Identification of UDP-glucose as an intermediate in the biosynthesis of the membrane-derived oligosaccharides of Escherichia coli. (1977) (33)
- Differential phosphorylation of MAP-2 stimulated by calcium-calmodulin and cyclic AMP (1984) (33)
- Serine/threonine kinases in the nervous system (1991) (33)
- Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease (2006) (31)
- Ca2+-dependent phosphorylation of tyrosine hydroxylase in PC12 cells (1985) (30)
- Phosphorylation of microtubule-associated protein-2 in GH3 cells. Regulation by cAMP and by calcium. (1991) (27)
- Persistent signalling and changes in presynaptic function in long-term potentiation. (1992) (26)
- Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation (2019) (23)
- Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells. (1994) (22)
- Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity (2014) (21)
- CaMKII Structure—An Elegant Design (2005) (21)
- Inhibition of a mammalian large conductance, calcium‐sensitive K+ channel by calmodulin‐binding peptides (2000) (19)
- Ca/Calmodulin-dependent Protein Kinase II in Heart Failure. (2010) (19)
- The multifunctional Ca2+/calmodulin-dependent protein kinase. (1988) (18)
- Distinct voltage‐dependent gating behaviours of a swelling‐activated chloride current in human epithelial cells. (1996) (17)
- Pharmacological characterization of histamine H2 receptors on clonal cytolytic T lymphocytes. Evidence for histamine-induced desensitization. (1984) (15)
- Calcium-dependent protein kinases and neuronal function (1984) (14)
- Chapter 11 – Calcium-Dependent Protein Phosphorylation in Mammalian Brain and Other Tissues (1980) (13)
- Beta 2-adrenergic receptors on peripheral nerves. (1986) (13)
- Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14. (1994) (12)
- Peptide inhibitors of PKC and CaMK block induction but not expression of long-term potentiation. (1990) (12)
- Protein phosphorylation system in bovine brain cytosol dependent on calcium and calmodulin. (1982) (10)
- Membrane-derived oligosaccharides , found in the Escherichia coli periplasmic space ( (2001) (8)
- In vivo and in vitro phosphorylation of murine lymphocyte differentiation antigen CD5. (1989) (8)
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca 2+/Calmodulin- Dependent Kinas (2011) (4)
- Conformational coupling by trans-phosphorylation in calcium calmodulin dependent kinase II (2019) (4)
- Calcium Regulation of Cytosolic Enzymes (1998) (4)
- Chapter 4 – Intracellular Signaling (2014) (3)
- CALCIUMICALMODULIN DEPENDENT PROTEIN KINASE: From Form to Function (1995) (3)
- An Analytical Procedure for the Determination of n-Heptyl p-Hydroxybenzoate in Beer (1965) (3)
- The Human in. Opioid Receptor: Modulation of Functional Desensitization by Calcium/Calmodulin-Dependent (1995) (2)
- Rabbit Ventricular Myocytes (2005) (2)
- Calcium/Calmodulin-Dependent Protein Kinase II (2013) (2)
- Chapter 9 – Intracellular Signaling (2013) (1)
- Multifunctional Ca 21 / Calmodulin-Dependent Protein Kinase Mediates Ca 2 +-Induced Enhancement of the L-type Ca 21 Current in Rabbit Ventricular Myocytes (2005) (1)
- Author response: Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II (2016) (1)
- Regulation of lymphocyte chloride channels. (1991) (1)
- Regulation of CaMKII Docking to NMDA Receptors by Calcium/Calmodulin and a -Actinin (2002) (0)
- CaMKII Substrate Complex A (2010) (0)
- Mechanism of ~utophosphorylation of the ~ u l t i f u n c t i ~ n a l ~a2+/Calmodulin-dependent Protein Kinase” (2001) (0)
- Subunit Expression AReceptors in Single Thalamic Neurons and GABA AKinetic and Pharmacological Properties of GABA (2000) (0)
- Ca 2 +-dependent protein phosphorylation system in membranes from various tissues , and its activation by " calcium-dependent regulator " ( calcium / protein kinase ) (2004) (0)
- Conformational coupling by trans-phosphorylation 7 in 8 calcium-calmodulin-dependent kinase II 9 10 11 (2019) (0)
- CaMKIINtide Inhibitor Complex (2010) (0)
- Response: Is Regulation of a Chloride Channel in Lymphocytes Affected in Cystic Fibrosis? (1989) (0)
- Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Localization Acts in Concert with Substrate Targeting to Create Spatial Restriction for Phosphorylation*□S (2005) (0)
- Symposium The role of postsynaptic protein kinases and phosphatases in calcium regulated synaptic plasticity (1998) (0)
- Calcium | Calcium/Calmodulin-Dependent Protein Kinase II (2021) (0)
- Differential Phosphorylation ofMAP-2Stimulated byCalcium- Calmodulin andCyclic AMP (1984) (0)
- Treatment of arrhythmias by inhibition of a multifunctional calcium dependent protein kinase / calmodulin. (1998) (0)
- Signal Transduction and Protein Phosphorylation (1995) (0)
- CHAPTER 12 – Intracellular Signaling (2004) (0)
- Treatment of cardiac arrhythmia by inhibition of a multifunctional calcium / calmodulin-dependent protein kinase (1998) (0)
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