Hugh Auchincloss

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Hugh Auchincloss is affiliated with the following schools: Yale University, Massachusetts General Hospital, Harvard University

Hugh Auchincloss 's AcademicInfluence.com Rankings

Hugh Auchincloss

Biology

#7348

World Rank

#10257

Historical Rank

#2198

USA Rank

Immunology

#476

World Rank

#493

Historical Rank

#85

USA Rank

biology Degrees

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Biology

Hugh Auchincloss 's Degrees

Doctorate Medicine Harvard University

Why Is Hugh Auchincloss Influential?

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According to Wikipedia, Hugh Auchincloss, Jr. is an American immunologist and physician serving as the acting director of the National Institute of Allergy and Infectious Diseases since 2023. He previously served as the principal deputy director between 2006 and 2022. He was previously a transplant surgeon and professor of surgery at Harvard Medical School, and researched at Massachusetts General Hospital for 17 years.

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Hugh Auchincloss 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

International trial of the Edmonton protocol for islet transplantation. (2006) (1482)
The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice (2003) (754)
Xenogeneic transplantation. A review. (1988) (376)
Direct and indirect recognition: the role of MHC antigens in graft rejection. (1999) (375)
The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. (1993) (332)
Xenogeneic transplantation. (1998) (317)
A phase I trial of immunosuppression with anti-ICAM-1 (CD54) mAb in renal allograft recipients. (1993) (294)
Mice lacking major histocompatibility complex class I and class II molecules. (1993) (275)
Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo (1994) (241)
SYMPTOMATIC CYTOMEGALOVIRUS DISEASE IN THE CYTOMEGALOVIRUS ANTIBODY SEROPOSITIVE RENAL TRANSPLANT RECIPIENT TREATED WITH OKT31,2 (1992) (225)
Two levels of help for B cell alloantibody production (1996) (224)
Xenogeneic skin graft rejection is especially dependent on CD4+ T cells (1989) (205)
A prospective, randomized, clinical trial of intraoperative versus postoperative thymoglobulin in adult cadaveric renal transplant recipients1 (2003) (176)
Effects of in vivo administration of anti-T3 monoclonal antibody on T cell function in mice. I. Immunosuppression of transplantation responses. (1988) (170)
Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo1 (2005) (165)
Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice (2008) (154)
Skin graft rejection by beta 2-microglobulin-deficient mice (1992) (150)
Antigen processing and presentation in transplantation. (1996) (147)
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. (2000) (146)
Mechanisms of transplantation tolerance. (1994) (137)
Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse (1990) (134)
Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory Blockade1 (2001) (131)
CD28-independent Costimulation of T Cells in Alloimmune Responses1 (2001) (131)
Acute Humoral Rejection in Hepatitis C‐Infected Renal Transplant Recipients Receiving Antiviral Therapy (2003) (127)
Liver transplantation for primary hepatic cancer. (1992) (126)
CD70 Signaling Is Critical for CD28-Independent CD8+ T Cell-Mediated Alloimmune Responses In Vivo1 (2005) (111)
LONG‐TERM METABOLIC AND QUALITY OF LIFE RESULTS WITH PANCREATIC/RENAL TRANSPLANTATION IN INSULIN‐DEPENDENT DIABETES MELLITUS (1991) (109)
EVIDENCE THAT MULTIPLE DEFECTS IN CELL‐SURFACE MOLECULE INTERACTIONS ACROSS SPECIES DIFFERENCES ARE RESPONSIBLE FOR DIMINISHED XENOGENEIC T CELL RESPONSES1 (1992) (108)
Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice. (1993) (105)
Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model. (2002) (104)
Effect of class II antigen matching on renal allograft survival in miniature swine (1984) (99)
The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection. (2002) (97)
The Effect of Low Versus High Dose of Streptozotocin in Cynomolgus Monkeys (Macaca Fascilularis) (2003) (91)
Role of CXC chemokine receptor 3 pathway in renal ischemic injury. (2006) (89)
In Search of the Elusive Holy Grail: the Mechanisms and Prospects for Achieving Clinical Transplantation Tolerance (2001) (81)
Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo1 (2004) (81)
The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade. (2002) (75)
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts (2007) (71)
DEPLETING ANTI-CD4 MONOCLONAL ANTIBODY CURES NEW-ONSET DIABETES, PREVENTS RECURRENT AUTOIMMUNE DIABETES, AND DELAYS ALLOGRAFT REJECTION IN NONOBESE DIABETIC MICE1 (2004) (69)
CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts. (1997) (64)
MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. (1995) (61)
A prospective, randomized, clinical trial of intraoperative versus postoperative thymoglobulin in adult cadaveric renal transplant recipients (2003) (60)
In vivo use of monoclonal antibodies against murine T cell antigens. (1989) (57)
Successful treatment of invasive fungal infection with fluconazole in organ transplant recipients. (1989) (56)
Xenografting: A review (1990) (54)
The strength of cell‐mediated xenograft rejection in the mouse is due to the CD4+ indirect response (1998) (52)
CARDIOVASCULAR RISK PROFILE AFTER CONVERSION FROM CYCLOSPORINE A TO TACROLIMUS IN STABLE RENAL TRANSPLANT RECIPIENTS (2004) (52)
CD4+ T cells, without CD8+ or B lymphocytes, can reject xenogeneic skin grafts (1994) (48)
Rejection of Mouse Cardiac Allografts by Costimulation in trans1 (2001) (47)
Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation. (2004) (46)
Further Analysis of the T‐Cell Subsets and Pathways of Murine Cardiac Allograft Rejection (2003) (45)
Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice. (2003) (45)
Prolonged Survival of Allogeneic Islets in Cynomolgus Monkeys After Short‐Term Anti‐CD154‐Based Therapy: Nonimmunologic Graft Failure? (2006) (42)
Trimethoprim-sulfamethoxazole compared with ciprofloxacin for the prevention of urinary tract infection in renal transplant recipients. A double-blind, randomized controlled trial. (1992) (40)
T cell recognition of xeno-MHC peptides during concordant xenograft rejection. (1996) (40)
Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. (2001) (39)
The high-risk liver allograft recipient. Should allocation policy consider outcome? (1992) (37)
PREVENTION OF ALLOANTIBODY FORMATION AFTER SKIN GRAFTING WITHOUT PROLONGATION OF GRAFT SURVIVAL (1988) (35)
T-cell subsets, bm mutants, and the mechanisms of allogeneic skin graft rejection (1989) (34)
Pig islet xenografts are resistant to autoimmune destruction by non‐obese diabetic recipients after anti‐CD4 treatment (2003) (34)
Involvement of the direct and indirect pathways of allorecognition in tolerance induction. (2001) (34)
Selective use of veno-venous bypass in orthotopic liver transplantation. (1996) (34)
IMMUNOLOGIC CHARACTERIZATION OF MHC RECOMBINANT SWINE: ROLE OF CLASS I AND II ANTIGENS IN IN VITRO IMMUNE RESPONSES (1984) (33)
Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. (1995) (32)
Effects of streptozotocin on autoimmune diabetes in NOD mice (2003) (32)
Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss (2008) (32)
Human anti‐pig cell‐mediated cytotoxicity in vitro involves non‐T as well as T cell components (1996) (32)
Xenotransplantation literature update (1997) (32)
Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus. (1981) (30)
Comparison of GK1.5 and chimeric rat/mouse GK1.5 anti-CD4 antibodies for prolongation of skin allograft survival and suppression of alloantibody production in mice. (1992) (29)
Procurement of a whole pancreas and liver from the same cadaveric donor. (1989) (28)
Anti-idiotypes to monoclonal anti-H-2 antibodies. III. Syngeneic anti-idiotypes on antibodies induced by in vivo administration of xenogeneic anti-idiotypes. (1982) (26)
Long-term, low-dose cyclosporine treatment of renal allograft recipients. A randomized trial. (1990) (25)
Mechanism of Cellular Xenograft Rejection (1991) (24)
Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response (2004) (24)
Murine CD8+ T cell helper function is particularly sensitive to cyclosporine suppression in vivo. (1989) (23)
Second renal transplantations. Ethical issues clarified by outcome; outcome enhanced by a reliable crossmatch. (1994) (23)
A monoclonal antibody detecting unusual Thy-1 determinants. (1982) (22)
Cell-mediated xenoresponses: strong or weak? (1994) (21)
Combined kidney and pancreas transplantation in diabetics. (1988) (21)
Prolonged Survival of Allogeneic Islets in Cynomolgus Monkeys After Short‐Term Triple Therapy (2012) (18)
Management of the renal allograft recipient: immunosuppressive protocols for long-term success. (1994) (18)
Cellular mechanisms of rejection. (1992) (18)
β3 Integrins Regulate Lymphocyte Migration and Cytokine Responses in Heart Transplant Rejection (2007) (17)
Studies of transplantation immunology with major histocompatibility complex knockout mice. (1997) (17)
Anti-idiotypes against anti-H-2 monoclonal antibodies: structural analysis of the molecules induced by in vivo anti-idiotype treatment. (1982) (16)
Rejection of transgenic skin expressing a xeno-class I antigen is CD4-dependent and CD8-independent. (1990) (15)
Antiidiotypes against anti-H-2 monoclonal antibodies. V. In vivo antiidiotype treatment induces idiotype-specific helper T cells (1983) (15)
Xenograft rejection of class I-expressing transgenic skin is CD4-dependent and CD8-independent. (1990) (14)
Mechanisms of tolerance in murine radiation bone marrow chimeras. I. Nonspecific suppression of alloreactivity by spleen cells from early, but not late, chimeras. (1983) (13)
The selective use of antilymphocyte serum for cyclosporine treated patients with renal allograft dysfunction. (1987) (12)
Delayed rejection of soluble tumor necrosis factor receptor-secreting tumor allografts. (1998) (11)
CD4+ lymphocytes play a dominant role in murine xenograft rejection. (1989) (11)
The Scientific Study of Xenografting: 1964–1988 (1991) (10)
The indirect pathway in graft rejection (1997) (10)
Report of the Food and Drug Administration Subcommittee on Xenotransplantation: meeting of 13 January 2000, Center for Biologics Evaluation and Research (1999) (10)
Cell-mediated xenograft rejection (1999) (9)
Contribution of native kidney function to total glomerular filtration rate after combined kidney-pancreas transplantation. (1998) (9)
Chapter 14 – Idiotypes of Anti-MHC Monoclonal Antibodies (1984) (7)
Ureteropyelostomy with a monofilament absorbable suture. (1987) (6)
Role of nuclear factor of activated T cell (NFAT) transcription factors in skin and vascularized cardiac allograft rejection. (2011) (6)
Transplantation of pancreatic islets in diabetic nonhuman primates. (1994) (6)
MECHANISMS OF TOLERANCE IN MURINE RADIATION BONE MARROW CHIMERAS (1983) (6)
The role of CD 154-CD 40 versus CD 28B 7 costimulatory pathways in regulating allogeneic Th 1 and Th 2 responses in vivo (2000) (6)
ANALYSIS OF THE ROLE OF NEGATIVE T CELL COSTIMULATORY PATHWAYS IN CD4 AND CD8 MEDIATED ALLOIMMUNE RESPONSES IN VIVO (2004) (6)
Hard graft? Future challenges in transplantation. (1991) (6)
The kidney transplant program at the Massachusetts general hospital. (2001) (5)
The Application of Xenotransplantation in Humans--Reasons to Delay. (1995) (5)
Phase I Clinical Trial of Anti-ICAM-1 (CD54) Monoclonal Antibody Immunosuppression in Renal Allograft Recipients (1993) (3)
Immunosuppression by cyclosporine in vivo need not block effector T-cell function in mice. (1989) (3)
TNF:TNF-R T-Cell costimulatory pathways in transplantation. (2001) (3)
Literature update 1998, part 2 (1998) (3)
Report of the Food and Drug Administration Subcommittee on Xenotransplantation: meeting of 3 and 4 June, 1999, Center for Biologics Evaluation and Research (1999) (3)
Transplantation More questions than answers (1998) (3)
Clarence Cook Little (1888–1971): The Genetic Basis of Transplant Immunology (2004) (3)
Failure to induce chimerism or tolerance in mice with monoclonal anti-T cell antibodies plus allogeneic bone marrow infusion. (1988) (3)
Literature update 1999, part 1 (1999) (2)
Defects in accessory molecule and other cell surface molecule interactions are responsible for weak mouse helper T-cell responses to xenoantigens. (1991) (2)
Role of graft in transplantation tolerance. (1995) (2)
CD70-CD27 is a critical CD28-independent costimulatory pathway for alloimmune CD8+T cell responses (2003) (2)
Modification of the immune response to h-2 antigens by treatment with antiidiotype. (1983) (2)
THE DIFFERENTIAL ROLE OF CD28‐B7 VERSUS CD40L‐CD40 IN REGULATING ALLOIMMUNE RESPONSES IN STAT 4 VERSUS STAT 6 GENE KNOCKOUT MICE.: Abstract# 1027 (2000) (1)
SUCCESSFUL INDUCTION OF TOLERANCE OF PANCREATIC ISLETS BETWEEN MHC‐MISMATCHED NONHUMAN PRIMATES.: Abstract# 740 (2000) (1)
LONG-TERM SURVIVAL OF CARDIAC ALLOGRAFTS INDUCED BY COSTIMULATORY BLOCKADE MAY REQUIRE INDIRECT RECOGNITION (1999) (1)
ISLET ALLOGRAFT SURVIVAL IN DIABETIC MONKEYS AFTER ANTI‐CD154, DST, AND SIROLIMUS TREATMENT: 0101 (2003) (1)
Two distinct murine differentiation antigens both determined by genes linked to the ly6 locus. Abstr. (1981) (1)
Literature update 1998, part 4 (1999) (1)
Literature update 1999, part 2 (1999) (1)
Evidence that a "four-cell cluster" may prime cytotoxic T-cells during graft rejection. (1993) (1)
Literature update 1999, part 3 (2000) (1)
MHC Class II Mutant Mice (1994) (0)
Literature update 1998, part 3 (1999) (0)
Allografts After Costimulatory Blockade Long-Term Survival of Murine Cardiac Expression Is Required to Achieve Cutting Edge: Recipient MHC Class II (2001) (0)
XENOGRAFT SURVIVAL OF FETAL PIG ISLETS IN MICE WITH CD4+ T CELLS BUT CLASS II−/− APC (1999) (0)
LIVER TRANSPLANTATION FOR PRIMARY HEPATIC CANCER1 (1992) (0)
The role of the novel gene, T-bet, in allograft rejection and tolerance. (2003) (0)
VivoChemokine/Chemokine Receptor Function In Allograft Rejection: Tissue Specificity of Differential Role of CCR2 in Islet and Heart (2003) (0)
Xenografting: Is It Feasible? (1993) (0)
Literature update 1997, part 3 (1998) (0)
Mechanisms of tolerance to allografts. (1994) (0)
ROLE OF CD4 AND CD8 T CELLS IN VASCULARIZED CARDIAC ALLOGRAFT REJECTION MEDIATED BY DIRECT AND INDIRECT ALLORECOGNITION.: Abstract# 498 Poster Board #‐Session: P138‐II (2000) (0)
TARGETING CHEMOKINE RECEPTORS CXCR3 AND CCR5 REDUCES RENAL ISCHEMIC INJURIES (2004) (0)
PROLONGED SURVIVAL OF CLASS II MATCHED RENAL ALLOGRAFTS expression of class II (2003) (0)
T CELL COSTIMULATORY BLOCKADE SUPPRESSES INDIRECT BETTER THAN DIRECT ALLOIMMUNE RESPONSES IN VIVO (1998) (0)
ISLET ALLOGRAFT SURVIVAL IN DIABETIC MONKEYS AFTER ANTI-CD154, DST, AND DELAYED REPAMYCIN TREATMENT (2004) (0)
A SHORT-TERM TREATMENT WITH A COMBINATION OF IL-2/Fc AND MUTANT IL-15/Fc FUSION PROTEINS PROLONGED ISLET GRAFT SURVIVAL IN DIABETIC CYNOMOLGUS MONKEYS (2004) (0)
Regulation of autoimmune diabetes in NOD mice: Critical role for the PD-1 : PD-L1 costimulatory pathway. (2002) (0)
ROLE OF GRAFT IN TRANSPLANTATION TOLERANCE. AUTHORS' REPLY (1995) (0)
NON‐IMMUNOLOGIC MECHANISMS OF ISLET ALLOGRAFT DYSFUNCTION: EFFECT OF DIABETES CONTROL ON ISLET ALLOGRAFT DYSFUNCTION.: Abstract# 370 Poster Board #‐Session: P10‐II (2000) (0)
COSTIMULATION IN TRANS CAN MEDIATE ACUTE REJECTION OF CARDIAC ALLOGRAFTS.: Abstract# 1164 (2000) (0)
Alloimmune Responses In Vivo CD28-Independent CD8+ T Cell-Mediated CD70 Signaling Is Critical for (2013) (0)
MECHANISMS OF ISLET ALLOGRAFT REJECTION: ROLE OF AUTOIMMUNITY AND EFFECT OF T CELL COSTIMULATORY BLOCKADE.: Abstract# 898 Poster Board #‐Session: P155‐III (2000) (0)
MA01.01 The Role of Surgery for M1a Non-Small-Cell Lung Cancer with Contralateral Lung Involvement (2021) (0)
Simultaneous procurement of pancreas and liver from a single cadaveric donor. (1989) (0)
Literature update 1999, part 3. Xenotransplantation. (2000) (0)
Literature update 2000, part 1 (2000) (0)
OA05.06 Early Diagnosis of Lung Cancer Among Younger vs. Older Adults: Widening Disparities in the Era of Lung Cancer Screening (2022) (0)
ROLES OF DONOR-DERIVED SELECTINS IN THE DEVELOPMENT OF BOTH ACUTE REJECTION AND GRAFT ARTERIOSCLEROSIS. (2006) (0)
B7‐1 IS THE DOMINANT LIGAND FOR CTLA‐4 DOWN REGULATION OF ALLOIMMUNE RESPONSES IN VIVO.: Abstract# 1157 (2000) (0)
Functions of the PD-1: PD-L1 costimulatory pathway in physiologic regulation of alloimmune responses in vivo (2003) (0)
Literature update (1997) (0)
Rejection of reliC Disparate Grafts by Wild-Type and ~ 2m Mutant Mice (2003) (0)
Literature update 1998, Part 1 (1998) (0)
Contributions by Paul S. Russell toward the future application of xenografting. (1991) (0)
Xenotransplantation literature update (1997) (0)
Literature update 1997, part 2 (1997) (0)
in Alloimmune Responses CD28-independent Costimulation of T Cells (2001) (0)
T cells regulate idiotype expression in mice primed with anti-idiotypes to anti-h-2 antibodies. Abstr. (1982) (0)
GENETIC BASIS OF RESISTANCE TO TRANSPLANTATION TOLERANCE INDUCTION IN NOD MICE. (2006) (0)
CONCURRENT SESSION 46: TRANSLATIONAL STUDIES IN NON-HUMAN PRIMATES (2006) (0)
SYNERGY BETWEEN SIGNAL 1 PLUS SIGNAL 2 BLOCKADE IN A STRINGENT MODEL OF ALLOGRAFT REJECTION.: Abstract# 998 (2000) (0)
Xenogeneic Transplantation: Immunologic Issues and Future Prospects (1991) (0)

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What Schools Are Affiliated With Hugh Auchincloss ?

Hugh Auchincloss is affiliated with the following schools:

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