Hugh Christian Watkins

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#3229

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Why Is Hugh Christian Watkins Influential?

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According to Wikipedia, Hugh Christian Watkins is a British cardiologist. He is a Fellow of Merton College, Oxford, an associate editor of Circulation Research, and was Field Marshal Alexander Professor of Cardiovascular Medicine in the University of Oxford between 1996 and 2013.

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Hugh Christian Watkins's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). (2014) (3171)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010) (2087)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study (2012) (2002)
Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010) (1961)
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (2011) (1928)
Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease (2015) (1567)
Large-scale association analysis identifies new risk loci for coronary artery disease (2012) (1507)
HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). (2011) (1263)
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. (2009) (1242)
New genetic loci link adipose and insulin biology to body fat distribution (2014) (1227)
Genome-wide association study identifies eight loci associated with blood pressure (2009) (1225)
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. (2005) (1085)
α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere (1994) (1049)
Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy. (1995) (871)
Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy (2010) (830)
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. (2014) (799)
Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. (1998) (762)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways (2012) (758)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance (2012) (756)
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries (2018) (735)
Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans (2015) (724)
Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. (1992) (713)
HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). (2011) (692)
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations (2012) (678)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (659)
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies (2012) (646)
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease (2011) (638)
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies (2010) (631)
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. (2016) (630)
Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. (1999) (628)
Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations (2009) (617)
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. (2009) (614)
Mutations in the cardiac myosin binding protein–C gene on chromosome 11 cause familial hypertrophic cardiomyopathy (1995) (599)
Mendelian randomization of blood lipids for coronary heart disease (2014) (580)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013) (568)
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data (2014) (547)
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
Inherited cardiomyopathies. (2011) (532)
Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples (2016) (529)
Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. (2008) (527)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma (2011) (526)
Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. (2001) (526)
Association analyses based on false discovery rate implicate new loci for coronary artery disease (2017) (476)
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017) (428)
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction (2014) (426)
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure (2011) (424)
Identification of Novel, Functional Genetic Variants in the Human Matrix Metalloproteinase-2 Gene (2001) (412)
FTO genotype is associated with phenotypic variability of body mass index (2012) (407)
A structural variation reference for medical and population genetics (2020) (394)
Sudden death due to troponin T mutations. (1997) (391)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. (2003) (378)
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults (2018) (359)
[2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy]. (2014) (354)
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population (2014) (348)
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016) (347)
Stratified Medical Therapy Using Invasive Coronary Function Testing in Angina: The CorMicA Trial. (2018) (341)
Cardiac Myosin Binding Protein C: Its Role in Physiology and Disease (2004) (328)
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders (2015) (319)
Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy: New Insights From Multiparametric Magnetic Resonance Imaging (2007) (311)
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. (2016) (309)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis (2017) (308)
Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion. (2003) (304)
Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants (2014) (303)
Myocardial Tissue Characterization Using Magnetic Resonance Noncontrast T1 Mapping in Hypertrophic and Dilated Cardiomyopathy (2012) (301)
Four paraoxonase gene polymorphisms in 11 212 cases of coronary heart disease and 12 786 controls: meta-analysis of 43 studies (2004) (300)
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing (2016) (294)
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. (2014) (292)
Inactivating mutations in NPC1L1 and protection from coronary heart disease. (2014) (289)
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. (2012) (282)
Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy. (1994) (280)
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. (2002) (265)
A mutation in the α tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy (1995) (256)
Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. (2004) (241)
Whole-genome sequencing of patients with rare diseases in a national health system (2020) (239)
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (2012) (238)
Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy (2010) (235)
Adaptation and validation of the ACMG/AMP variant classification framework for MYH7-associated inherited cardiomyopathies: recommendations by ClinGen’s Inherited Cardiomyopathy Expert Panel (2018) (233)
Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway (2012) (232)
Genetic susceptibility to coronary artery disease: from promise to progress (2006) (232)
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease (2011) (228)
Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency* (2009) (227)
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms (2017) (224)
Genetically determined height and coronary artery disease. (2015) (220)
A Randomized Trial of Deferred Stenting Versus Immediate Stenting to Prevent No- or Slow-Reflow in Acute ST-Segment Elevation Myocardial Infarction (DEFER-STEMI) (2014) (210)
Validation of Magnetic Resonance Myocardial Perfusion Imaging With Fractional Flow Reserve for the Detection of Significant Coronary Heart Disease (2009) (207)
Dilated and Hypertrophic Cardiomyopathy Mutations in Troponin and &agr;-Tropomyosin Have Opposing Effects on the Calcium Affinity of Cardiac Thin Filaments (2007) (207)
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease (2017) (204)
Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. (1994) (203)
Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3. (1994) (203)
Genetic evidence of assortative mating in humans (2017) (199)
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes (2011) (197)
Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy. (1999) (193)
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study (2011) (185)
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility (2015) (185)
Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes. (1991) (183)
Meta-Analysis of Gene Level Tests for Rare Variant Association (2013) (183)
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias (2012) (180)
Blood pressure loci identified with a gene-centric array. (2011) (177)
A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity. (1998) (175)
A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3 (1993) (173)
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2. (1993) (167)
Cardiac Nitric Oxide Synthase 1 Regulates Basal and &bgr;-Adrenergic Contractility in Murine Ventricular Myocytes (2002) (167)
Genetic variation at the matrix metalloproteinase-9 locus on chromosome 20q12.2–13.1 (1999) (165)
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. (2016) (164)
The index of microcirculatory resistance measured acutely predicts the extent and severity of myocardial infarction in patients with ST-segment elevation myocardial infarction. (2010) (161)
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. (2013) (160)
Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function. (1998) (159)
Truncated Estrogen Receptor &agr; 46-kDa Isoform in Human Endothelial Cells: Relationship to Acute Activation of Nitric Oxide Synthase (2003) (158)
Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. (2012) (158)
Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy. (2011) (157)
Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes (2017) (155)
The Trans-Ancestral Genomic Architecture of Glycemic Traits (2020) (151)
Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. (2014) (150)
Altered Regulatory Properties of Human Cardiac Troponin I Mutants That Cause Hypertrophic Cardiomyopathy* (2000) (149)
Germline selection shapes human mitochondrial DNA diversity (2019) (148)
Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction (2014) (147)
A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. (2005) (143)
Myocardial Hemorrhage After Acute Reperfused ST-Segment–Elevation Myocardial Infarction (2016) (141)
Differentiation of athlete's heart from pathological forms of cardiac hypertrophy by means of geometric indices derived from cardiovascular magnetic resonance. (2004) (140)
Clinical features of hypertrophic cardiomyopathy caused by mutation of a "hot spot" in the alpha-tropomyosin gene. (1997) (139)
Dilated Cardiomyopathy Mutations in Three Thin Filament Regulatory Proteins Result in a Common Functional Phenotype* (2005) (139)
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations. (1992) (139)
Sudden death in hypertrophic cardiomyopathy. (2000) (138)
Rare variants in NR2F2 cause congenital heart defects in humans. (2014) (138)
A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy (2010) (138)
Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action. (1996) (137)
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease (2017) (135)
DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model. (2010) (135)
Alterations in Thin Filament Regulation Induced by a Human Cardiac Troponin T Mutant That Causes Dilated Cardiomyopathy Are Distinct from Those Induced by Troponin T Mutants That Cause Hypertrophic Cardiomyopathy* (2002) (135)
Comparison of Different Diastolic Resting Indexes to iFR: Are They All Equal? (2017) (134)
Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease (2013) (133)
The power of genetic diversity in genome-wide association studies of lipids (2021) (129)
Genetic Cardiomyopathies Causing Heart Failure (2013) (124)
Systemic microvascular dysfunction in microvascular and vasospastic angina (2018) (123)
Validation of a novel non-hyperaemic index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study. (2018) (122)
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney (2017) (121)
Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction (2015) (121)
Ischemia and No Obstructive Coronary Artery Disease (2019) (121)
Pathophysiology of LV Remodeling in Survivors of STEMI (2015) (120)
A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. (1995) (119)
Identification of Novel Interactions Between Domains of Myosin Binding Protein-C That Are Modulated by Hypertrophic Cardiomyopathy Missense Mutations (2002) (118)
Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype. (2007) (117)
Hypertrophic Cardiomyopathy Registry: The rationale and design of an international, observational study of hypertrophic cardiomyopathy. (2015) (116)
Comparative Prognostic Utility of Indexes of Microvascular Function Alone or in Combination in Patients With an Acute ST-Segment–Elevation Myocardial Infarction (2016) (115)
Familial hypertrophic cardiomyopathy: a genetic model of cardiac hypertrophy. (1995) (115)
Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population: A Genome-Wide Evaluation of 13 974 Participants in the Women’s Genome Health Study (2009) (115)
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy (2020) (115)
Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy (2020) (114)
Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy. (2010) (113)
Prognostic significance of infarct core pathology revealed by quantitative non-contrast in comparison with contrast cardiac magnetic resonance imaging in reperfused ST-elevation myocardial infarction survivors (2015) (112)
Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies (2016) (110)
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (2014) (110)
Distinct Subgroups in Hypertrophic Cardiomyopathy in the NHLBI HCM Registry. (2019) (107)
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis (2015) (106)
Mutations of the Light Meromyosin Domain of the &bgr;-Myosin Heavy Chain Rod in Hypertrophic Cardiomyopathy (2002) (105)
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin (2019) (104)
A common mitochondrial DNA variant associated with susceptibility to dilated cardiomyopathy in two different populations (2001) (103)
Reduced Inotropic Reserve and Increased Susceptibility to Cardiac Ischemia/Reperfusion Injury in Phosphocreatine-Deficient Guanidinoacetate-N-Methyltransferase–Knockout Mice (2005) (103)
Temporal Evolution of Myocardial Hemorrhage and Edema in Patients After Acute ST‐Segment Elevation Myocardial Infarction: Pathophysiological Insights and Clinical Implications (2016) (103)
Mutations in fast skeletal troponin I, troponin T, and β‐tropomyosin that cause distal arthrogryposis all increase contractile function (2007) (102)
Genome-Wide Mapping of Susceptibility to Coronary Artery Disease Identifies a Novel Replicated Locus on Chromosome 17 (2006) (102)
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018) (100)
Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis (2015) (100)
Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity (2021) (99)
1-Year Outcomes of Angina Management Guided by Invasive Coronary Function Testing (CorMicA) (2019) (98)
Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia (2013) (98)
Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect (2020) (98)
Left ventricular hypertrophy and morphology in familial hypertrophic cardiomyopathy associated with mutations of the beta-myosin heavy chain gene. (1993) (97)
Living Without Creatine: Unchanged Exercise Capacity and Response to Chronic Myocardial Infarction in Creatine-Deficient Mice (2013) (96)
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. (2012) (93)
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (93)
Supranormal Myocardial Creatine and Phosphocreatine Concentrations Lead to Cardiac Hypertrophy and Heart Failure: Insights From Creatine Transporter–Overexpressing Transgenic Mice (2005) (93)
Whole genome sequencing of a sporadic primary immunodeficiency cohort (2018) (92)
Personalized medicine: hope or hype? (2012) (92)
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease (2019) (90)
Transcript expression-aware annotation improves rare variant interpretation (2020) (89)
Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry (2009) (88)
Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy (2009) (88)
Integrated Physiologic Assessment of Ischemic Heart Disease in Real-World Practice Using Index of Microcirculatory Resistance and Fractional Flow Reserve: Insights From the International Index of Microcirculatory Resistance Registry (2015) (88)
Evaluating drug targets through human loss-of-function genetic variation (2019) (86)
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. (2012) (85)
Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility. (1997) (85)
Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension (2017) (84)
Prognostic value of plasma interleukin-6 concentrations and the -174 G > C and -572 G > C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis. (2004) (82)
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome. (2006) (80)
Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy (2018) (80)
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function (2016) (80)
Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. (2013) (80)
Secretory Phospholipase A2-IIA and Cardiovascular Disease (2013) (78)
Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2019) (78)
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. (2019) (77)
Identification of Myocardial Disarray in Patients With Hypertrophic Cardiomyopathy and Ventricular Arrhythmias (2019) (77)
Comparison of hemodynamic performance of self-expandable CoreValve versus balloon-expandable Edwards SAPIEN aortic valves inserted by catheter for aortic stenosis. (2013) (76)
Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay. (2000) (76)
Effect of Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention on Microvascular Obstruction in Patients With Acute Myocardial Infarction: A Randomized Clinical Trial (2019) (75)
Genotype: phenotype correlations in hypertrophic cardiomyopathy. (1998) (75)
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. (2016) (75)
Erratum: A mutation in the α tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1 (Nature Genetics (1995) 9 (75-79)) (1995) (75)
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps (2016) (75)
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction (2012) (75)
AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes (2012) (75)
Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass. (2002) (74)
Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. (2000) (74)
The Effect of Mutations in α-Tropomyosin (E40K and E54K) That Cause Familial Dilated Cardiomyopathy on the Regulatory Mechanism of Cardiac Muscle Thin Filaments* (2007) (74)
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. (2013) (72)
Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications (2018) (71)
Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling (2018) (70)
Bright-Blood T2-Weighted MRI Has High Diagnostic Accuracy for Myocardial Hemorrhage in Myocardial Infarction: A Preclinical Validation Study in Swine (2011) (69)
Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. (2005) (69)
The effect of LRRK2 loss-of-function variants in humans (2020) (69)
Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy (2010) (67)
A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1. (1995) (67)
Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod. (2007) (67)
A saturated map of common genetic variants associated with human height (2022) (65)
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease (2017) (64)
Human stromelysin gene promoter activity is modulated by transcription factor ZBP‐89 (1999) (63)
In vivo cardiac 1H‐MRS in the mouse (2004) (62)
Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction (2016) (62)
Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments (2015) (62)
Discordance Between Resting and Hyperemic Indices of Coronary Stenosis Severity: The VERIFY 2 Study (A Comparative Study of Resting Coronary Pressure Gradient, Instantaneous Wave-Free Ratio and Fractional Flow Reserve in an Unselected Population Referred for Invasive Angiography) (2016) (61)
The role of vascular myoglobin in nitrite-mediated blood vessel relaxation (2010) (60)
Pre-symptomatic genetic testing for inherited cardiac conditions: a qualitative exploration of psychosocial and ethical implications (2013) (60)
A De Novo Mutation in α-Tropomyosin That Causes Hypertrophic Cardiomyopathy (1995) (60)
Gender specific patterns of age-related decline in aortic stiffness: a cardiovascular magnetic resonance study including normal ranges (2015) (60)
Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy. (1993) (59)
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease (2018) (59)
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape (2016) (59)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2020) (58)
Mechanisms of creatine depletion in chronically failing rat heart. (2005) (57)
Paraoxonase polymorphisms and coronary heart disease (2004) (56)
Erratum: HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies (Europace (2011) 13 (1077-1109) DOI: 10.1093/europace/eur245) (2012) (56)
Blunted Myocardial Oxygenation Response During Vasodilator Stress in Patients With Hypertrophic Cardiomyopathy (2013) (55)
Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity. (2010) (55)
Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathies: implications for kinase function and disease pathogenesis. (2003) (54)
“Not pathogenic until proven otherwise”: perspectives of UK clinical genomics professionals toward secondary findings in context of a Genomic Medicine Multidisciplinary Team and the 100,000 Genomes Project (2017) (54)
Sex‐specific characteristics of cardiac function, geometry, and mass in young adult elite athletes (2006) (53)
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. (2005) (53)
Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers (2018) (53)
The genetics of hypertrophic cardiomyopathy: Teare redux (2007) (52)
Ambulatory Blood Pressure Is Associated With Polymorphic Variation in P2X Receptor Genes (2008) (52)
Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. (2015) (51)
Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction. (2015) (51)
A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families (2005) (51)
Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction (2020) (50)
Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk (2012) (49)
Persistent Iron Within the Infarct Core After ST-Segment Elevation Myocardial Infarction (2017) (46)
The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy (2008) (46)
Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes (2009) (46)
Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease (2019) (46)
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants (2021) (45)
Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration (2015) (45)
Impact of lipoprotein(a) levels and apolipoprotein(a) isoform size on risk of coronary heart disease (2014) (45)
Remote Zone Extracellular Volume and Left Ventricular Remodeling in Survivors of ST-Elevation Myocardial Infarction (2016) (44)
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C (2019) (44)
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy (2013) (44)
Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling (2018) (44)
Heart Rhythm UK position statement on clinical indications for implantable cardioverter defibrillators in adult patients with familial sudden cardiac death syndromes. (2010) (43)
Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes (2018) (43)
Microvascular resistance of the culprit coronary artery in acute ST-elevation myocardial infarction (2016) (42)
Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility. (2002) (42)
Familial and phenotypic associations of the aldosterone Renin ratio. (2009) (42)
Current Smoking and Prognosis After Acute ST-Segment Elevation Myocardial Infarction (2019) (42)
Genotype at the −174G/C Polymorphism of the Interleukin-6 Gene Is Associated With Common Carotid Artery Intimal-Medial Thickness: Family Study and Meta-Analysis (2005) (42)
Genetic clues to disease pathways in hypertrophic and dilated cardiomyopathies. (2003) (42)
Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR) (2021) (42)
Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases. (2019) (42)
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets (2018) (41)
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk (2014) (40)
Association of exome sequences with plasma C-reactive protein levels in >9000 participants. (2015) (40)
Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia. (2016) (39)
Multiple disease genes cause hypertrophic cardiomyopathy. (1994) (39)
Exome Sequencing Identifies Rare Variants in Multiple Genes in Atrioventricular Septal Defect (2015) (39)
Mammalian γ2 AMPK regulates intrinsic heart rate (2017) (38)
Cardiac and skeletal actin gene mutations are not a common cause of dilated cardiomyopathy (1999) (38)
Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension. (2008) (37)
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations (2019) (37)
Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yield (2018) (37)
Common Genetic Determinants of Lung Function, Subclinical Atherosclerosis and Risk of Coronary Artery Disease (2014) (37)
Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure (2005) (36)
Diastolic pressure ratio: new approach and validation vs. the instantaneous wave-free ratio. (2019) (36)
Nprl3 is required for normal development of the cardiovascular system (2012) (35)
Mutations in cis can confound genotype-phenotype correlations in hypertrophic cardiomyopathy (2001) (35)
Corrigendum: A mutation in the α tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy NEM1 (1995) (35)
Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. (2009) (35)
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death (2015) (34)
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. (2016) (34)
Coronary Artery Disease-Related Genetic Variant on Chromosome 10q11 Is Associated With Carotid Intima-Media Thickness and Atherosclerosis (2010) (34)
Intravascular lithotripsy to treat a severely underexpanded coronary stent. (2019) (33)
No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure (2015) (33)
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity (2016) (33)
Localisation of AMPK γ subunits in cardiac and skeletal muscles (2013) (32)
Genetic variation in CADM2 as a link between psychological traits and obesity (2019) (32)
Measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo 7T 31P-cardiovascular magnetic resonance spectroscopy (2019) (31)
Improvements in ECG accuracy for diagnosis of left ventricular hypertrophy in obesity (2016) (30)
JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells (2018) (30)
Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations (2020) (30)
Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification (2012) (30)
Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. (2006) (29)
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. (2019) (28)
Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities (2018) (28)
Toward Replacing Late Gadolinium Enhancement With Artificial Intelligence Virtual Native Enhancement for Gadolinium-Free Cardiovascular Magnetic Resonance Tissue Characterization in Hypertrophic Cardiomyopathy (2021) (28)
Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice – a one year longitudinal MRI study (2008) (27)
The Genomic Architecture of Sporadic Heart Failure (2011) (27)
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure* (2015) (27)
Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. (2016) (27)
Circumferential Strain Predicts Major Adverse Cardiovascular Events Following an Acute ST-Segment-Elevation Myocardial Infarction. (2019) (27)
Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6): support for the locus assignment, narrowing of the critical region and mutation screening of three candidate genes (2006) (27)
Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention (2018) (26)
Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart (2012) (26)
Assignment of the human a-tropomyosin gene TPM3 to 1q22-->q23 by fluorescence in situ hybridisation. (1995) (26)
Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle (2008) (26)
A de novo mutation in alpha-tropomyosin that causes hypertrophic cardiomyopathy. (1995) (26)
Is Wolff‐Parkinson‐White Syndrome a Genetic Disease? (2005) (26)
De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures (2018) (26)
Hypertension, Microvascular Pathology, and Prognosis After an Acute Myocardial Infarction (2018) (25)
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis (2016) (25)
Comparative Significance of Invasive Measures of Microvascular Injury in Acute Myocardial Infarction (2020) (25)
Views of rare disease participants in a UK whole-genome sequencing study towards secondary findings: a qualitative study (2018) (24)
Genetically modulated educational attainment and coronary disease risk. (2019) (24)
Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study (2017) (24)
The prognostic impact of septal myectomy in obstructive hypertrophic cardiomyopathy. (2005) (23)
The phenotype/genotype relation and the current status of genetic screening in hypertrophic cardiomyopathy, Marfan syndrome, and the long QT syndrome. (1997) (23)
Functional effects of the DCM mutant Gly159Asp Troponin C in skinned muscle fibres (2007) (23)
Assessment of Fractional Flow Reserve in Patients With Recent Non–ST-Segment–Elevation Myocardial Infarction: Comparative Study With 3-T Stress Perfusion Cardiac Magnetic Resonance Imaging (2015) (22)
Progress in familial hypertrophic cardiomyopathy: molecular genetic analyses in the original family studied by Teare. (1992) (22)
Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial☆☆☆ (2018) (22)
Safety of guidewire-based measurement of fractional flow reserve and the index of microvascular resistance using intravenous adenosine in patients with acute or recent myocardial infarction (2016) (22)
Functional Significance of SRJ Domain Mutations in CITED2 (2012) (22)
Plasma cytokines and risk of coronary heart disease in the PROCARDIS study (2018) (22)
Insights from early experience of a Rare Disease Genomic Medicine Multidisciplinary Team: a qualitative study (2017) (21)
Differential Gene Expression in Macrophages From Human Atherosclerotic Plaques Shows Convergence on Pathways Implicated by Genome-Wide Association Study Risk Variants (2018) (21)
Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies (2013) (21)
Reevaluation of the South Asian MYBPC3Δ25bp Intronic Deletion in Hypertrophic Cardiomyopathy (2020) (21)
DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes (2018) (21)
Common Variation at the 11-&bgr; Hydroxysteroid Dehydrogenase Type 1 Gene Is Associated With Left Ventricular Mass (2011) (20)
The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension. (2007) (20)
Analysis of the Role of Interleukin 6 Receptor Haplotypes in the Regulation of Circulating Levels of Inflammatory Biomarkers and Risk of Coronary Heart Disease (2015) (20)
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)) (2010) (20)
Ambulatory Blood Pressure Is Associated With Polymorphic Variation in P 2 X Receptor Genes (2008) (19)
Multiple QTL influence the serum Lp(a) concentration: a genome-wide linkage screen in the PROCARDIS study (2007) (18)
Redefining Adverse and Reverse Left Ventricular Remodeling by Cardiovascular Magnetic Resonance Following ST-Segment–Elevation Myocardial Infarction and Their Implications on Long-Term Prognosis (2020) (18)
The effects of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease (2018) (18)
Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits (2016) (18)
Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series (2019) (17)
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (17)
Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion (2018) (17)
Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass (2011) (17)
31P cardiac magnetic resonance spectroscopy during leg exercise at 3 Tesla (2009) (16)
Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study (2018) (16)
Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: an analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). (2014) (16)
Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy (2005) (16)
CalTrack: High Throughput Automated Calcium Transient Analysis in Cardiomyocytes. (2021) (16)
Sex differences in procedural and clinical outcomes following rotational atherectomy (2019) (16)
Time to Think Differently About Sarcomere-Negative Hypertrophic Cardiomyopathy (2021) (16)
Changes in creatine transporter function during cardiac maturation in the rat (2010) (16)
A multisystem, cardio-renal investigation of post-COVID-19 illness (2022) (16)
Secretory Phospholipase A2-IIA and Cardiovascular Disease A Mendelian Randomization Study (2017) (16)
The molecular genetics of hypertrophic cardiomyopathy. (1997) (15)
The effect of percutaneous coronary intervention of chronically totally occluded coronary arteries on left ventricular global and regional systolic function. (2013) (15)
Hereditary postlingual sensorineural hearing loss mapping to chromosome Xq21. (1999) (15)
Waiting for the working draft from the human genome project (2000) (15)
Culotte stenting for coronary bifurcation lesions with 2nd and 3rd generation everolimus-eluting stents: the CELTIC Bifurcation Study. (2018) (15)
A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression. (2018) (14)
Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction (2017) (14)
Genetic analysis of over one million people identifies 535 novel loci for blood pressure (2017) (14)
Predictors of segmental myocardial functional recovery in patients after an acute ST-Elevation myocardial infarction (2019) (13)
Measured haplotype analysis of the aldosterone synthase gene and heart size (2003) (13)
Fractional flow reserve (FFR) versus angiography in guiding management to optimise outcomes in non-ST segment elevation myocardial infarction (FAMOUS-NSTEMI) developmental trial: cost-effectiveness using a mixed trial- and model-based methods (2015) (13)
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant (2021) (12)
Measured haplotype analysis of the aldosterone synthase gene and heart size (2005) (12)
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction (2019) (12)
Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (2022) (12)
Genetic determinants of plasma β2‐glycoprotein I levels: a genome‐wide association study in extended pedigrees from Spain (2013) (12)
Hypertrophic cardiomyopathy: from molecular and genetic mechanisms to clinical management (2001) (11)
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease (2020) (11)
Variation in thromboxane B2 concentrations in serum and plasma in patients taking regular aspirin before and after clopidogrel therapy (2015) (11)
Hypertrophic cardiomyopathy in Noonan Syndrome closely mimics familial hypertrophic cardiomyopathy due to sarcomeric mutations (2006) (11)
Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease. (2020) (11)
Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials (2022) (11)
Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: New insights from multiparametric MRI (2007) (10)
Persistence of infarct zone T2 hyperintensity at 6 months after acute ST-elevation myocardial infarction: incidence, pathophysiology and prognostic implications (2017) (10)
Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension (2007) (10)
Genotype at the 174 G / C Polymorphism of the Interleukin-6 Gene Is Associated With Common Carotid Artery Intimal-Medial Thickness Family Study and Meta-Analysis (2005) (10)
Assigning a causal role to genetic variants in hypertrophic cardiomyopathy. (2013) (9)
Human Genetic Evidence for Involvement of CD137 in Atherosclerosis (2014) (9)
Dilated cardiomyopathy and the desmin gene. (2000) (9)
Effects of Intracoronary Alteplase on Microvascular Function in Acute Myocardial Infarction (2020) (9)
Secondary findings in inherited heart conditions: a genotype-first feasibility study to assess phenotype, behavioural and psychosocial outcomes (2020) (9)
Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome (2019) (9)
No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects (2014) (9)
Enhancement of beta adrenergic responsiveness in myocytes lacking nitric oxide synthase 1 (2001) (9)
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes (2021) (9)
Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage (2020) (9)
Functional analyses of cardiomyopathic cardiac troponin T mutants in myocyte culture (1997) (9)
Percutaneous coronary intervention versus medical therapy in patients with angina and grey-zone fractional flow reserve values: a randomised clinical trial (2020) (9)
Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca2+, and activate NFAT and Akt signaling (2020) (9)
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening (2021) (9)
Maximal Wall Thickness Measurement in Hypertrophic Cardiomyopathy: Biomarker Variability and its Impact on Clinical Care. (2021) (9)
Genetic Variants from Lipid-Related Pathways and Risk for Incident Myocardial Infarction (2013) (9)
Incremental value of left atrial booster and reservoir strain in predicting atrial fibrillation in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance study (2021) (8)
Do health professionals value genomic testing? A discrete choice experiment in inherited cardiovascular disease (2019) (8)
ABSENCE OF MAJOR DELETIONS OR REARRANGEMENTS OF CARDIAC MYOSIN HEAVY-CHAIN GENES IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY (1993) (8)
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits : (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x) (2018) (8)
Incidence of procedural myocardial infarction and cardiac magnetic resonance imaging-detected myocardial injury following percutaneous coronary intervention with rotational atherectomy. (2018) (8)
Erratum: Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure (The Journal of Biological Chemistry (2015) 290 (25907-25919) DOI: 10.1074/jbc.M115.665695) (2016) (8)
Persistence of Infarct Zone T2 Hyperintensity at 6 Months After Acute ST-Segment–Elevation Myocardial Infarction (2017) (8)
An evaluation of ribonuclease protection assays for the detection of beta-cardiac myosin heavy chain gene mutations. (1994) (8)
Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes (2020) (8)
Development and validation of a short 31P cardiac magnetic resonance spectroscopy protocol (2010) (8)
Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric DCM (2009) (8)
Predictors of Major Atrial Fibrillation Endpoints in the National Heart, Lung, and Blood Institute HCMR. (2021) (8)
Functional estrogen receptor alpha promoter polymorphism is associated with improved endothelial-dependent vasolidation. (2010) (8)
Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy. (2023) (8)
8 Myocardial haemorrhage after acute reperfused st-elevation myocardial infarction: temporal evolution, relation to microvascular obstruction and prognostic significance (2015) (8)
Electrocardiographic abnormalities of hypertrophic cardiomyopathy (2014) (8)
Dystrophinopathies are characterised by impaired cardiac metabolism, contractile dysfunction and fibrosis in patients with and without coxsackie B3 exposure (2011) (7)
A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL. (2008) (7)
Five-year outcomes of staged percutaneous coronary intervention in the SYNTAX study. (2015) (7)
Inherited Aortopathy Assessment in Relatives of Patients With a Bicuspid Aortic Valve. (2017) (7)
Sex-based associations with microvascular injury and outcomes after ST-segment elevation myocardial infarction (2019) (6)
Risk Stratification Guided by the Index of Microcirculatory Resistance and Left Ventricular End-Diastolic Pressure in Acute Myocardial Infarction (2021) (6)
Genotype at the P554L Variant of the Hexose-6 Phosphate Dehydrogenase Gene Is Associated with Carotid Intima-Medial Thickness (2011) (6)
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome (2021) (6)
Evolution of genetic analysis strategies in coronary heart disease: a case of unnatural selection? (2001) (6)
Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification (2021) (6)
Meta-Analysis of Gene Level Association Tests (2013) (6)
Obesity-related ventricular remodelling is exacerbated in dilated and hypertrophic cardiomyopathy. (2020) (6)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids (2021) (6)
Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)) (2012) (6)
Non-invasive imaging of myocardial disarray associates with ventricular arrhythmia in hypertrophic cardiomyopathy (2017) (5)
Coronary Thermodilution Waveforms After Acute Reperfused ST‐Segment–Elevation Myocardial Infarction: Relation to Microvascular Obstruction and Prognosis (2018) (5)
Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease (2018) (5)
The diagnosis of familial hypertrophic cardiomyopathy in children. (1998) (5)
HeterozygousABCG5Gene Deficiency and Risk of Coronary Artery Disease (2020) (5)
Coronary artery disease genetics: bigger is better. (2004) (5)
FAMILIAL HYPERTROPHIC CARDIOMYOPATHY IS A DISEASE OF THE SARCOMERE (1994) (5)
Abstract 17123: Association of Apolipoprotein(a) Isoforms With Coronary Heart Disease is Mediated Through Plasma Lipoprotein(a) Levels (2010) (5)
A common mitochondrial DNA variant is associated with idiopathic dilated cardiomyopathy in two different populations (2000) (5)
Familial hypertrophic cardiomyopathy: man, mouse and cat. (1998) (5)
Magnetic resonance myocardial perfusion imaging: a new era in the detection of reversible myocardial ischaemia (2006) (5)
Synchronous in situ ATPase activity, mechanics, and Ca2+ sensitivity of human and porcine myocardium. (2009) (5)
Oxidized phospholipids on apolipoprotein B-100 versus plasminogen and risk of coronary heart disease in the PROCARDIS study. (2022) (5)
Manhattan++: displaying genome-wide association summary statistics with multiple annotation layers (2019) (5)
Impact of Molecular Genetics on Clinical Cardiology (1999) (5)
A dinucleotide repeat polymorphism in the human LAMB2 gene on chromosome 1q. (1993) (4)
Myocardial dysfunction in hypertrophic cardiomyopathy. (2001) (4)
TCT-154 Diagnostic Accuracy of iFR Versus FFR in the Left Versus Right Coronary Artery (2018) (4)
From Genotype to Phenotype: Clinical Assessment and Participant Perspective of a Secondary Genomic Finding Associated with Long QT Syndrome (2018) (4)
Coronary Artery Perforations: Glasgow Natural History Study of Covered Stent Coronary Interventions (GNOCCI) Study (2019) (4)
Cardiac troponin I is a potential novel substrate for AMP-activated protein kinase (2007) (4)
Mechanical effects of human cardiac troponin C mutation Gly159Asp in exchanged rabbit psoas fibres (2004) (4)
A Noncontrast CMR Risk Score for Long-Term Risk Stratification in Reperfused ST-Segment Elevation Myocardial Infarction. (2022) (4)
A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. (2018) (4)
Ascertainment strategies and genotype:phenotype correlations in hypertrophic cardiomyopathy. (2003) (4)
Right ventricular function declines prior to left ventricular ejection fraction in hypertrophic cardiomyopathy (2022) (4)
Heritability of haemodynamics in the ascending aorta (2020) (4)
Defective inhibitory properties of human cardiac troponin I mutants that cause familial hypertrophic cardiomyopathy (FHC) (1998) (4)
IDENTIFICATION OF NOVEL MYOSIN MUTATIONS THAT CAUSE FAMILIAL HYPERTROPHIC CARDIOMYOPATHY (1992) (4)
Evidence for a quantitative trait locus for plasma fibrinogen from a family–based association study (2001) (4)
Tackling the Achilles’ Heel of Genetic Testing (2015) (4)
Genetic association studies in coronary disease: the cause of GPIIb-IIIa polymorphisms. (1999) (4)
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation (2017) (4)
Erratum to: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps : (Nature Genetics, (2016), 48, 11, (1303-1312), 10.1038/ng.3668) (2018) (3)
Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease (2021) (3)
Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name? (2007) (3)
Evidence for haploinsufficiency as the mechanism of action of MyBP-C mutations that cause HCM (2008) (3)
081 Acute derangement of cardiac energy metabolism and oxygenation during stress in hypertrophic cardiomyopathy—a potential mechanism for sudden cardiac death (2012) (3)
Mutation analysis of genes encoding Subunits of AMP-activated protein kinase (AMPK) in inherited cardiomyopathies (2002) (3)
Characterisation of a novel cardiac phenotype in patients with GFPT1 or DPAGT1 mutations (2014) (3)
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (3)
One-Year Outcomes After Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention: The T-TIME Randomized Trial. (2020) (3)
Heterozygous disruption of SERCA2a is not sufficient to impair cardiac performance in man (2002) (3)
Novel Potential Treatment of Familial Hypertrophic Cardiomyopathy with Analogues of the Green Tea Polyphenol Epigallocatechin-3-Gallate (2016) (3)
79 Diagnostic Accuracy of Myocardial Fractional Flow Reserve for Reversible Perfusion Abnormalities in Patients with Recent Non-ST Elevation Myocardial Infarction (2014) (3)
Extraction of morphological QRS-based biomarkers in hypertrophic cardiomyopathy for risk stratification using L1 regularized logistic regression (2015) (3)
Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: A cautionary tale (2009) (3)
Daubert v. Merrell Dow Pharmaceuticals, Inc.: General Acceptance Rejected (1994) (3)
Adaptation and validation of the ACMG / AMP variant classification framework for MYH 7-associated inherited cardiomyopathies (2018) (3)
A regional propensity for arrhythmogenesis is determined by a regional difference in the NA-CA exchanger (2002) (3)
A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I (2006) (3)
MYBPC3 Mutations cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for Therapy (2018) (3)
The genetics of cardiovascular disease : from genotype to phenotype (2005) (3)
Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study. (2021) (2)
Animal models of familial hypertrophic cardiomyopathy. (1999) (2)
Comparative study of costs and resource utilisation of rotational atherectomy versus intravascular lithotripsy for percutaneous coronary intervention. (2021) (2)
2 NEW LOCI FOR HYPERTROPHIC CARDIOMYOPATHY MAP TO CHROMOSOME-15Q2 (CMH3) AND CHROMOSOME-11Q (CMH4) (1993) (2)
A trinucleotide repeat polymorphism in XT00444 (D13S635E). (1994) (2)
Genetic loci influencing C-reactive protein levels and coronary heart disease risk: results of genetic association and Mendelian randomisation study with meta-analysis in 80 614 people (2009) (2)
Hypertrophic cardiomyopathy mutations in the gamma 2 subunit of AMP-activated kinase suggest a central role of energy compromise in disease pathogenesis (2001) (2)
PHACTR1 modulates vascular compliance but not endothelial function: a translational study (2022) (2)
Adenosine stress CMR T1 mapping detects impaired perfusion and inducible myocardial ischaemia without gadolinium contrast or ionizing radiation in hypertrophic cardiomyopathy (2017) (2)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (2)
121 Re-evaluating the genetic contribution of monogenic dilated cardiomyopathy (2019) (2)
Derangement of cardiac high energy phosphate metabolism in patients with left ventricular non-compaction and preserved ejection fraction (2006) (2)
Mitochondrial DNA point mutations in idiopathic dilated cardiomyopathy (1998) (2)
Validation of the “smart” minimum FFR Algorithm in an unselected all comer population of patients with intermediate coronary stenoses (2017) (2)
Chronic Activation of g2 A MPK Induces Obesity and Reduces b Cell Function (2016) (2)
A dinucleotide repeat polymorphism in the MYBPH gene. (1994) (2)
Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans. (2016) (2)
Stratified medicine using invasive coronary function testing in angina: A cost-effectiveness analysis of the British Heart Foundation CorMicA trial. (2021) (2)
Non-contrast T1 mapping characterizes the myocardium beyond that achieved by late gadolinium enhancement in both hypertrophic and dilated cardiomyopathy (2012) (2)
Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney (2017) (2)
Left ventricular anatomy in obstructive hypertrophic cardiomyopathy: beyond basal septal hypertrophy. (2022) (2)
Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy (2)
Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020) (2)
Functional effects of hypertrophic cardiomyopathy mutations in alpha-tropomyosin on Ca2+ regulation of thm filaments (1998) (2)
Data-driven modelling of mutational hotspots and in-silico predictors in hypertrophic cardiomyopathy (2019) (2)
Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease (2019) (2)
Detection of Mutations by RNase Cleavage (1997) (2)
Direct measurement of myofilament calcium in living cardiomyocytes (2018) (2)
Marked variation in heritability estimates of left ventricular mass depending on modality of measurement (2019) (2)
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size (2021) (2)
HYPERTENSION, MICROVASCULAR PATHOLOGY AND PROGNOSIS IN PATIENTS WITH AN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (2017) (2)
Quantitative Trait Genetic Linkage Analysis of Body Mass Index in Familial Coronary Artery Disease (2008) (2)
Prognostic significance of infarct core pathology in ST-elevation myocardial infarction survivors revealed by quantitative T2-weighted cardiac magnetic resonance (2015) (2)
Patients with Dilated Cardiomyopathy (DCM) have appropriate myocardial oxygenation response to vasodilator stress (2013) (2)
Novel mutations in cardiac MYBPC3 causing early onset malignant hypertrophic cardiomyopathy (2005) (2)
13 Natural history and clinical significance of infarct zone extracellular volume and remodelling in survivors of acute STEMI (2015) (1)
Polymorphism upstream of estrogen receptor alpha reverses negative regulation of transcription. (2010) (1)
Combinated transfection of wild type and a hypertrophic cardiomyopathy mutant cardiac troponin T makes quail myotubes likely good turn in expression and functional assessment. (1996) (1)
Abstract 1478: AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility in Murine Ventricular Myocytes (2007) (1)
Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C. (2001) (1)
Measurement of myofilament calcium in living cardiomyocytes using a targeted genetically encoded indicator (2018) (1)
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease (2022) (1)
ANRIL, THE NON CODING RNA PRESENT IN THE CHROMOSOME 9 CAD ASSOCIATED LOCUS, HAS MULTIPLE SPLICE VARIANTS AND A POTENTIAL REGULATORY ROLE IN CDKN2B EXPRESSION (2009) (1)
Data-driven modelling of mutational hotspots and in silico predictors in hypertrophic cardiomyopathy (2020) (1)
Met and unmet needs: evidence of significant health and social problems in bipolar II disorders from the MRC UK, 'ABC' Cohort study (2012) (1)
Genome-Wide Association Study of Over One Million Participants Identifies 49 Novel Loci Associated With Coronary Artery Disease (2019) (1)
Bi-allelic MCM10 mutations cause telomere shortening with immune dysfunction and cardiomyopathy (2019) (1)
38 T1 and T2 Mapping Have Higher Diagnostic Accuracy for the Ischaemic Area-at-risk in Nstemi Patients Compared with Dark Blood Imaging (2014) (1)
Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy (2023) (1)
Displacement Encoding With Stimulated Echoes Enables the Identification of Infarct Transmurality Early Postmyocardial Infarction (2020) (1)
Discrepancy Between Pathological Progression and Clinical Stability in a Young Patient With Hypertrophic Cardiomyopathy. (2018) (1)
Left ventricular non-compaction (LVNC): Insights from cardiovascular magnetic resonance (CMR) imaging (2005) (1)
Enhanced Myocardial Repair with CardioChimeras (2013) (1)
Journal size increases to four volumes per year Editorial Board additions (1995) (1)
Analyses of cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy (1992) (1)
AORTIC STENOSIS WITH IMPAIRED VENTRICULAR FUNCTION MANIFESTS IMPAIRED CARDIAC METABOLISM: IMPLICATIONS FOR PROGNOSIS AND SURGICAL INTERVENTION (2009) (1)
Angina, quality of life and prognosis: prospective comparison of patients undergoing invasive management (2020) (1)
A novel mutation in phospholamban causes a mixed hypertrophic and dilated cardiomyopathy phenotype with autosomal dominant inheritance (2004) (1)
Comparison of the functional effects of mutations in troponin T which cause dilated and hypertrophic cardiomyopathies (2002) (1)
Predictors of death in hypertensive families followed up over 14 years (2007) (1)
Abstract 2548: The Index Of Microvascular Resistance Measured Acutely Predicts The Severity And Nature Of Myocardial Infarction In Patients With St Segment Elevation Myocardial Infarction (2008) (1)
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020) (1)
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland. (2019) (1)
Novel polymorphism in estrogen receptor alpha reverses negative transcriptional regulation and is associated with improved endothelial-dependent vasodilation (2005) (1)
A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations (2002) (1)
Measured haplotype analysis of the aldosterone synthase gene and cardiac hypertrophy (2002) (1)
Exercise Acutely Exacerbates Derangement Of Cardiac Energy Metabolism In Hypertrophic Cardiomyopathy, a 31 Phosphorus Magnetic Resonance Study at 3 Telsa (2011) (1)
Derangement of cardiac energy metabolism is acutely exacerbated during exercise in hypertrophic cardiomyopathy, independent of hypertrophy or late gadolinium burden (2012) (1)
A common mitochondrial DNA variant is associated with susceptibility to idiopathic dilated cardiomyopathy in two different populations. (2000) (1)
Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps (2018) (1)
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus (2020) (1)
011 Adenosine stress T1 mapping: a novel contrast free method to assess myocardial perfusion and ischaemia in hypertrophic cardiomyopathy (2017) (1)
GENETIC TESTING FOR HYPERTROPHIC CARDIOMYOPATHY - REPLY (1992) (1)
The C-532T polymorphism of the angiotensinogen (AGT) gene is associated with arterial stiffness: A possible explanation for heterogeneity in genetic association studies of AGT and hypertension (2007) (1)
Transcript expression-aware annotation improves rare variant interpretation (2020) (1)
Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide lipidome reveal genetic influence over circulating lipids (2019) (1)
Mammalian γ2 AMPK regulates intrinsic heart rate (2017) (1)
Chronic Activation of g 2 AMPK Induces Obesity and Reduces b Cell Function (2016) (1)
Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin (2007) (1)
Insights into disease mechanisms of cardiomyopathy in the presence of the CSRP3 C58G mutation (2017) (1)
Ca2+regulatory properties of a truncated troponin T that causes FHC depend on the ratio of mutant to wild-type peptide. (2000) (1)
Lp(a) (Lipoprotein[a]), an Exemplar for Precision Medicine (2020) (1)
Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation (2019) (1)
Pathophysiology of myocardial remodeling in survivors of ST-elevation myocardial infarction revealed by native T1 mapping: inflammation, remote myocardium and prognostic significance (2015) (1)
Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series (2019) (1)
Loci for insulin processing and secretion provide insight into type 2 diabetes risk. (2023) (1)
Oral abstract presentations & Young Investigators Competition (2012) (1)
FGL1 as a modulator of plasma D‐dimer levels: Exome‐wide marker analysis of plasma tPA, PAI‐1, and D‐dimer (2021) (1)
Expression and functional assessment of hypertrophic cardiomyopathy-linked missense mutants of cardiac troponin T. (1997) (1)
No Evidence of Myocardial Oxygen Deprivation in Non-Ischemic Heart Failure Dass et al: No Evidence of Deoxygenation in DCM (2015) (1)
Response to Letter Regarding Article, "The Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction". (2016) (1)
Erratum: Rare variants in NR2F2 cause congenital heart defects in humans (The American Journal of Human Genetics (2014) 94 (574-585) (2014) (1)
EFFICACY AND SAFETY OF AFICAMTEN AND DISOPYRAMIDE COADMINISTRATION IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: RESULTS FROM REDWOOD-HCM COHORT 3 (2022) (1)
Altered regulatory function of two FHC Troponin T mutants. (1998) (1)
Abstract 329: T2-weighted MRI Has High Diagnostic Accuracy for Myocardial Hemorrhage in Myocardial Infarction: A Preclinical Validation Study in Swine (2009) (1)
Validation of first pass magnetic resonance myocardial perfusion imaging using fractional flow reserve (2009) (1)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021) (1)
Localization of a novel N-terminal cardiac MyBP-C binding site on myosin rod (2007) (0)
Sudden death referrals to the West of Scotland Inherited Cardiac Conditions Clinic: an overview of findings in probands with a structurally normal heart (2013) (0)
Redo aortic valve replacement vs valve-in-valve trans-catheter aortic valve implantation: a UK propensity-matched analysis. (2023) (0)
Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT (2020) (0)
PROGNOSTIC SIGNIFICANCE OF QUANTITATIVE MEASURES OF MYOCARDIAL INFARCT PATHOLOGY IN SURVIVORS OF ST-ELEVATION MYOCARDIAL INFARCTION (2015) (0)
Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland. (2018) (0)
Treatment of Anomalous Coronary Arteries—Surgical Revascularisation Using the Pure Internal Thoracic Artery Technique (2023) (0)
A multisystem, cardio-renal investigation of post-COVID-19 illness (2022) (0)
TCT-528 GLAsgow MRI ROtational AtheRectOmy Study: Physiology Reflects Procedural Success. The GLAMOROS Study. (2016) (0)
Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland. (2018) (0)
Abstract 5449: Diagnostic Performance of Perfusion Cardiovascular Magnetic Resonance Compared With Gated Myocardial Perfusion SPECT in Patients With Known or Suspected Coronary Artery Disease (2009) (0)
he Index of Microcirculatory Resistance easured Acutely Predicts the Extent and everity of Myocardial Infarction in Patients ith ST-Segment Elevation Myocardial Infarction (0)
Myocardial haemorrhage after acute reperfused ST-elevation myocardial infarction evolves progressively and contributes to the early bimodal pattern in T2-relaxation time: advanced imaging and clinical significance (2016) (0)
Fractional flow reserve versus Coronary Angiography guided management in non-st elevation myocardial infarction: a Health economic analysis (2015) (0)
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial 1 infarction improves cardiac function and reduces infarct size . 2 Running title : (2021) (0)
Angina After Percutaneous Coronary Intervention: Patient and Procedural Predictors (2023) (0)
073 T2-weighted MRI has high diagnostic accuracy for myocardial haemorrhage in myocardial infarction: a preclinical validation study in swine (2010) (0)
Abstracts of Societies (2011) (0)
SEGMENTAL CIRCUMFERENTIAL STRAIN DERIVED FROM DENSE PREDICTS IMPROVEMENT OF LEFT VENTRICULAR FUNCTION POST ST ELEVATION MYOCARDIAL INFARCTION: THE BHF MR-MI STUDY (2017) (0)
Post-COVID-19 illness trajectory: a multisystem investigation. (2021) (0)
4 Extracellular volume in the infarct zone is associated with clinical and mri measures of infarct severity in survivors of acute stemi (2015) (0)
TCT-529 The correlation between Quantitative Flow Ratio (QFR) and Fractional Flow Reserve (FFR) (2017) (0)
157 Multi-system investigation of covid-19 illness (2022) (0)
5 Relationships between infarct zone extracellular volume and clinical measures of ischaemia and reperfusion in acute STEMI survivors (2015) (0)
114 Persistence of Haemoglobin Degradation Products within Infarct Scar Tissue after ST-elevation Myocardial Infarction: Incidence, Correlates and Implications for Left Ventricular Remodelling (2016) (0)
PATHOPHYSIOLOGY OF MYOCARDIAL REMODELING IN SURVIVORS OF ST-ELEVATION MYOCARDIAL INFARCTION: INFLAMMATION, REMOTE MYOCARDIUM AND PROGNOSIS (2015) (0)
Meta-Analysis of the Index of Microvascular Resistance in Acute STEMI Using Incomplete Data. (2017) (0)
TCT-185 Glasgow Rotational Atherectomy Efficiency (GRACE) study: Safety of a Minimalist Approach (2018) (0)
PROGNOSTIC SIGNIFICANCE OF CO-EXISTING PERSISTENT EDEMA AND HEMORRHAGE AT 6 MONTHS IN SURVIVORS OF ST-ELEVATION MYOCARDIAL INFARCTION (2017) (0)
BAS/BSCR39 Circulating chemical and cellular injury/repair responses are linked to cardiac dysfunction and remodelling in human myocardial infarction (2010) (0)
Abstract 11365: The Index of Microcirculatory Resistance Does Not Change Following Emergency Percutaneous Intervention in St-elevation Myocardial Infarction (2012) (0)
27 Rationale and design of the effect of mineralocorticoid receptor antagonist therapy in patients with acute myocardial infarction or injury and non-obstructive coronary arteries: a registry-based, stratified-medicine, randomised, controlled trial (2023) (0)
115 Persistence of Infarct Zone Oedema at 6 Months after Acute ST-elevation Myocardial Infarction: Incidence, Pathophysiology and Association with Left Ventricular Remodelling (2016) (0)
25 Diagnostic Value of Myocardial Blood Flow Imaging in Patients with Ischaemia and Non-Obstructive Coronary Arteries (2023) (0)
TCT-84 Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS - NSTEMI) Clinical Trial: Study Design and Baseline Characteristics of Randomized Participants. (2013) (0)
CMR versus SPECT for diagnosis of coronary heart disease (2012) (0)
A COMPREHENSIVE COMPARISON OF THE PATHOPHYSIOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF CORONARY FLOW RESERVE AND THE INDEX OF MICROVASCULAR RESISTANCE IN THE CULPRIT CORONARY ARTERY OF PATIENTS WITH ACUTE ST-ELEVATION MYOCARDIAL INFARCTION (2016) (0)
P6432Overlooked prognostic markers in NSTEMI: insights from the BHF FAMOUS-NSTEMI trial (2018) (0)
Prognostic significance of quantitative measures of myocardial infarct pathology using native T1 mapping, in survivors of ST-elevation myocardial infarction (2015) (0)
TCT-591 A Comparison of Clinical and Coronary Physiology Characteristics in Patients With and Without Type 4a Myocardial Infarction Following High Speed Rotational Atherectomy–Assisted Percutaneous Coronary Intervention (2019) (0)
CURRENT SMOKING, MICROVASCULAR PATHOLOGY AND ADVERSE OUTCOME AFTER ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: NEW PATHOPHYSIOLOGICAL INSIGHTS (2017) (0)
Prognostic significance of infarct core pathology in ST-elevation myocardial infarction survivors revealed by non-contrast T1 mapping cardiac magnetic resonance (2015) (0)
2 Coronary flow reserve and index of microvascular resistance in acute stemi (2016) (0)
Correspondence of Invasive FFR vs. perfusion MRI at 3tesla in patients with recent NSTEMI (2014) (0)
TCT-405 Sex Differences and Outcomes Following Rotational Atherectomy: Do Women Receive Optimal Care? (2018) (0)
FRACTIONAL FLOW RESERVE (FFR) VERSUS ANGIOGRAPHY IN GUIDING MANAGEMENT TO OPTIMIZE OUTCOMES IN NON-ST ELEVATION MYOCARDIAL INFARCTION (FAMOUS - NSTEMI) HEALTH ECONOMIC ANALYSIS (2015) (0)
TCT-231 The Glasgow Trans-radial Rotablation Registry - A Retrospective Analysis of High-speed Rotational Atherectomy. (2016) (0)
TCT-255 Clinical and Coronary Physiology Characteristics of Patients With Residual Angina After Percutaneous Coronary Intervention (2022) (0)
5 Effect of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease (2018) (0)
50 Ischaemia and No Obstructive Coronary Artery Disease (INOCA): prevalence and predictors of coronary vasomotion disorders (2019) (0)
Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19 (2023) (0)
29 Verify 2 (Final Results): A Comparison of FFR vs Resting Indices of Stenosis Severity for Decision Making in the cath lab. nct02377310 (2016) (0)
TCT CONNECT-28 Left Ventricular End-Diastolic Pressure in Acute Myocardial Infarction, Association With Infarct Pathology, Left Ventricular Function, and Health Outcomes (2020) (0)
TCT-23 Derivation and Validation of Temperature Recovery Time as an Invasive Predictor of Microvascular Obstruction and Prognosis After ST-Segment Elevation Myocardial Infarction. (2018) (0)
TCT-82 Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS - NSTEMI) Clinical Trial: Relationships Between FFR and Angiographic Stenosis Severity at Baseline. (2013) (0)
Circulation: Cardiovascular Interventions. (2016) (0)
044 A RANDOMISED CONTROLLED TRIAL OF DEFERRED STENTING VERSUS IMMEDIATE STENTING TO PREVENT NO-REFLOW IN ACUTE ST-ELEVATION MYOCARDIAL INFARCTION (2013) (0)
12 The influence of microvascular obstruction on the relationship between remote zone extracellular volume and subsequent left ventricular volumes in survivors of ST-elevation myocardial infarction (2015) (0)
Abstract 4867: Circulating Chemical and Cellular Injury/Repair Responses Are Linked to the Extent of Heart Injury in Human Myocardial Infarction (2009) (0)
DECISION MAKING USING FRACTIONAL FLOW RESERVE IS ASSOCIATED WITH LOWER RATES OF INCOMPLETE REVASCULARIZATION COMPARED WITH ANGIOGRAPHIC GUIDED DECISION MAKING AMONGST PATIENTS WITH NSTEMI (2017) (0)
University of Dundee Pathophysiology of LV Remodeling in Survivors of STEMI Inflammation, Remote Myocardium, and Prognosis Carrick, (2016) (0)
INCIDENCE AND PROGNOSTIC IMPLICATIONS OF THE PRESENCE OF MULTIPLE COMPLEX PLAQUES IN SURVIVORS OF ST-ELEVATION MYOCARDIAL INFARCTION (2017) (0)
1140 CLINICAL OUTCOME OF FRACTIONAL FLOW RESERVE GUIDED REVASCULARIZATION STRATEGY OF CORONARY LESIONS: THE HALE-BOPP STUDY (2022) (0)
Diagnostic performance of perfusion cardiovascular magnetic resonance compared with gated myocardial perfusion spect in patients with known or suspected coronary artery disease (2010) (0)
Autosomal dominant nemaline myopathy - positional cloning to a mutation in tropomyosin 3 (1995) (0)
Massively Parallel Sequencing of 43 Arrhythmia Genes in a Selected SUDI Cohort from Cape Town (2021) (0)
An actin-binding site mutation in tropomyosin 3 causing autosomal dominant nemaline myopathy (1995) (0)
Amplification of sequences from affected individuals. (2001) (0)
Dr. John L. Hamerton steps-down from the Associate Editorship (1995) (0)
Gene expression analysis demonstrates presence of a non-coding RNA (ANRIL) in human islets and FACs sorted beta cells which has a potential regulatory role on CDKN2B expression (2009) (0)
Is DNA testing for hypertrophic cardiomyopathy cost-effective? (2006) (0)
Cardiomyopathy-causing mutations in cardiac thin filament regulatory proteins acutely affect Ca2+ buffering and Ca2+ dependant signalling in situ (2012) (0)
P3 Aortopathy assessment in bicuspid aortic valve disease relatives (2016) (0)
Demonstrations that cardiac troponin T mutations cause hypertrophic cardiomyopathy. (1995) (0)
Multi-Parametric Cardiovascular Magnetic Resonance Imaging (CMR) Detects Myocardial Fibrosis and Impaired Strain in Patients with Dystrophinopathies Even in the Presence of Normal Left Ventricular Ejection Fraction (2010) (0)
Genetic Testing for Cardiomyopathies (2010) (0)
Common Genetic Variants Associated With Higher Lp(a) Concentrations and Increased Risk of Coronary Heart Disease (2009) (0)
COMMON OR RARE GENETIC VARIATION IN THE CHEMOKINE RECEPTORS CCR2, CCR5, AND CX3CR1 DOES NOT RELATE TO CORONARY HEART DISEASE OR MYOCARDIAL INFARCTION IN HUMANS (2016) (0)
Evidence for a shared genetic determination of Ischemic Stroke And Coronary Artery Disease - a genome-wide analysis (2013) (0)
Inherited aortopathy assessment in bicuspid aortic valve disease relative (2016) (0)
Author Correction: A structural variation reference for medical and population genetics (2021) (0)
Maximal Wall Thickness Measurement in Hypertrophic Cardiomyopathy (0)
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2 (2023) (0)
Predictors of atrial emptying function in patients with hypertrophic cardiomyopathy: insights from cardiovascular magnetic resonance (2012) (0)
ECG phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients versus Purkinje-myocardial coupling abnormalities. (2018) (0)
Abstract 10150: Is the Myocardium Oxygen Deprived in Non Ischemic Heart Failure? (2013) (0)
MODE OF ACTION OF CARDIAC TROPONIN-T MUTATIONS IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY (1994) (0)
Whole-genome sequencing of rare disease patients in a national healthcare system (2020) (0)
Genetic Variants in Lp(a) Lipoprotein and Coronary Disease REPLY (2010) (0)
Are geometric indices, derived from cardiac magnetic resonance (CMR) able to differentiate various forms of cardiac hypertrophy? (2004) (0)
The effect of HCM mutations in troponin T and troponin I on the calcium binding of human cardiac troponin (2001) (0)
2032 The relationship between electrocardiographic and cardiac magnetic resonance (CMR)-derived left ventricular parameters differs between physiologic and pathologic hypertrophy (2008) (0)
Cited2 haploinsufficiency is associated with congenital heart defects in mouse and man: Introducing the GO-CHD Study (2006) (0)
THROMBOSIS AND HEMOSTASIS Rare and low-frequency variants and their association with plasma levels of ﬁ brinogen, FVII, FVIII, and vWF (2015) (0)
Functional analysis of hypertrophic cardiomyopathy missense mutations in the light meromyosin region of beta myosin heavy chain (2003) (0)
Hypertrophic cardiomyopathy (1992) (0)
Abstract 2076: Common Genetic Variants Associated With Higher Lp(a) Concentrations and Increased Risk of Coronary Heart Disease (2009) (0)
PREDICTORS OF CLINICALLY SIGNIFICANT ATRIAL FIBRILLATION IN THE NHLBI HYPERTROPHIC CARDIOMYOPATHY REGISTRY (HCMR) (2020) (0)
Views of rare disease participants in a UK whole-genome sequencing study towards secondary findings: a qualitative study (2018) (0)
University of Groningen Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease (2011) (0)
A novel truncated estrogen receptor alpha isoform in human endothelial cells: Role in acute versus transcriptional responses (2002) (0)
LONG-TERM EFFICACY AND SAFETY OF AFICAMTEN IN PATIENTS WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (2023) (0)
Linked genetic modifiers in hypertrophic cardiomyopathy (2004) (0)
Electrocardiographic markers of cardiac hypertrophy show greater heritability than echocardiographic left ventricular mass: A family study (2002) (0)
University of Groningen Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci Tragante, (2014) (0)
Identification of a novel mitochondrial NADH dehydrogenase I (MTND1) gene mutation in two patients with hypertrophic cardiomyopathy (2001) (0)
Two center study to assess the functional relevance of myocardial fibrosis in muscular dystrophy patients with and without left ventricular systolic dysfunction (2010) (0)
Monogenic causes of cardiac hypertrophy: hypertrophic cardiomyopathy and related phenotypes (2005) (0)
Using ‘next-generation’ sequencing in the identification of novel causes of inherited heart diseases (2013) (0)
A titan of Cardiovascular Research: Professor Peter Sleight (1929-2020). (2021) (0)
Delineating the role of adenosine monophosphate (AMP)-activated protein kinase (AMP) gamma 2 subunit in hypertrophic cardiomyopathy (HCM) (2005) (0)
Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes. (2023) (0)
Association Between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights From a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach. (2021) (0)
Genome-Wide Association Identi ﬁ es Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes (2011) (0)
Identification of a novel mitochondrial DNA mutation in the ND1 gene in 2 patients with hypertrophic cardiomyopathy with restrictive physiology (2001) (0)
SA98GENETIC ANALYSIS OF CADM2, A POSSIBLE LINK BETWEEN MENTAL AND PHYSICAL HEALTH (2019) (0)
Analyses of recombinant mutant cardiac troponin T in vitro and in myocyte culture (1997) (0)
31P cardiac magnetic resonance spectroscopy during physiological leg exercise at 3 Tesla (2007) (0)
Functional Estrogen Receptor Alpha Promoter Polymorphism is Associated with Improved LDL Cholesterol (2007) (0)
MyBP-C Role in Thick Filament Formation Binding to the Light Meromyosin Region of the Myosin (2004) (0)
ENERGETIC DEFICIENCY AND ADENOSINE RECEPTOR SIGNALLING IN CARDIAC FIBROSIS Abstracts (2018) (0)
The growth hormone inducible transmembrane gene is a novel genetic modifier of left ventricular hypertrophy in families with hypertrophic cardiomyopathy (2009) (0)
Genotype-phenotype correlations in hypertrophic cardiomyopathy can be confounded by double mutations in a single disease gene (2000) (0)
The Molecular Genetics of Familial Hypertrophic Cardiomyopathy (1993) (0)
Investigation of the functional effects of FHC-associated mutations in troponin T and troponin I by expression of intact human cardiac troponin in E-coli (1999) (0)
Specific Nature of Mutations in the AMP-Activated Protein Kinase That Cause Hypertrophic Cardiomyopathy (2003) (0)
Association between aldosterone production and variation in the gene encoding 11-beta hydroxylase (CYP11B1) (2007) (0)
Abstract 10736: Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics (2011) (0)
88 HCM and DCM mutations in thin filament proteins have opposite effects on regulation of contractility in vitro (2003) (0)
Impaired Stress Myocardial Oxygenation and Not Perfusion Reserve is Associated With Arrhythmic Risk in Hypertrophic Cardiomyopathy: Insights From a Novel Oxygen Sensitive Cardiac Magnetic Resonance Approach (2019) (0)
Association of a common mitochondrial DNA D-loop variant with idiopathic dilated cardiomyopathy in two different populations (2000) (0)
Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy (2019) (0)
In vivo assessment of metabolism in the hypertensive rat heart using hyperpolarized [1-C] and [2-C]pyruvate (2010) (0)
Left and right ventricular tissue velocities are reduced in hypertrophic cardiomyopathy but not in athlete's heart (2008) (0)
Title : Germline selection shapes the landscape of human mitochondrial DNA (2019) (0)
Genetic variation in CADM2 as a link between psychological traits and obesity (2019) (0)
Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death (2012) (0)
Disease Presenting as Autosomal Recessive Hypercholesterolemia Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage (2013) (0)
Localisation of AMPK γ subunits in cardiac and skeletal muscles (2013) (0)
Identification and functional analysis of cardiac troponin I as a novel disease gene in autosomal dominant familial dilated cardiomyopathy (2006) (0)
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease (2023) (0)
Functional effects of mutations in troponin T and tropomyosin which cause dilated cardiomyopathy (2003) (0)
Edinburgh Research Explorer Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes (2018) (0)
Enhanced prediction of gene and missense rare-variant pathogenicity by joint analysis of gene burden and amino-acid residue position (2019) (0)
Abstract 17133: Cardiac Steatosis Detected in Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy and Aortic Stenosis (2011) (0)
Title 1 Distinct genetic architectures for syndromic and nonsyndromic congenital 2 heart defects identified by exome sequencing 3 (2016) (0)
Myoglobin is involved in vasodilatation by nitrite (2009) (0)
Distribution of ancestry in each cohort. (2020) (0)
Abstract 571: MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy by Dysregulating Myosin: Implications for Therapy (2018) (0)
Genetic Variation at the CYP11B Locus Accounts for Heritabilities of Aldosterone Metabolite (THAldo) Excretion and 11Beta-Hydroxylase Activity: 56 (2006) (0)
AFICAMTEN IN PATIENTS WITH SYMPTOMATIC NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (REDWOOD-HCM COHORT 4) (2023) (0)
Genetic analyses in hypertrophic cardiomyopathy. (1997) (0)
Functional Effects of the Novel Dilated Cardiomyopathy-Causing Mutation Gly159Asp in Cardiac Troponin C in skinned muscle fibres. (2007) (0)
Crucial functions of alpha-actinin 2 in the embryonic heart (2022) (0)
Apolipoprotein Proteomics for Residual Lipid-Related Risk in Coronary Heart Disease (2023) (0)
ASSESSMENT OF THE MOLECULAR DEFECT IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY (1993) (0)
Plasma C-reactive protein (CRP), a novel cardiovascular risk factor, shows high heritability but no association with the-174 G/C polymorphism of the interleukin-6 (IL-6) gene in human families. (2000) (0)
Identiﬁcation of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study (2009) (0)
A structural variation reference for medical and population genetics (2020) (0)
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2020) (0)
A commonly occurring estrogen receptor alpha promoter polymorphism alters transcriptional regulation and is associated with increased HDL levels (2007) (0)
Effects of hypertrophic cardiomyopathy mutations in alpha-tropomyosin on Ca++ regulation of contractility (1997) (0)
Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease (2018) (0)
ASSOCIATION STUDY OF CORONARY ARTERY DISEASE (CAD) USING HUMANCVD 50K CHIP (2009) (0)
Reply: CMR Assessment of Myocyte Disarray in HCM: Matching Another Piece in the Puzzle. (2019) (0)
A Cardiac Nitric Oxide Synthase 1 Regulates Contraction and Calcium Fluxes – a Novel Mechanism Involved in the Autocrine Control of Cardiac Function (2002) (0)
Oxford Molecular Genetics Laboratory Cardiomyopathy Service (2006) (0)
Edinburgh Research Explorer Secretory Phospholipase A2-IIA and Cardiovascular Disease (2018) (0)
Paraoxonase polymorphisms and coronary heart disease. Authors' reply (2004) (0)
Investigating impulsivity in bipolar II disorder: more state than trait? (2012) (0)
HSP27 phosphorylation regulates a mechanosensitive interaction with filamin C (2017) (0)
Genetics, pathophysiology, and prognosis of hypertrophic cardiomyopathy (1991) (0)
The alpha-tropomyosin Asp175Asn missense mutation causes a benign form of hypertrophic cardiomyopathy (1996) (0)
Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps (2018) (0)
Abstract 10667: Mendelian Randomization of Lp(a) Levels and Coronary Disease Risk (2011) (0)
LPA null mutation genotyping and qPCR analysis refine kringle isoform analysis of Lp(a) levels (2014) (0)
Effects of DCM mutations in thin filament regulatory proteins on contractile function (2005) (0)
Cardiovascular Magnetic Resonance Imaging and Spectroscopy Detects Myocardial Fibrosis and Lipidosis in Patients with Dystrophinopathies, Even in the Presence of Normal Left Ventricular Ejection Fraction (2010) (0)
2378Blunted stress myocardial oxygenation and not myocardial perfusion reserve is associated with arrhythmic risk in hypertrophic cardiomyopathy (2019) (0)
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy. (2023) (0)
Molecular Genetics: New Mutations that Cause Familial Hypertrophic Cardiomyopathy (1995) (0)
6 RV function deteriorates earlier than LV function and predicts adverse cardiovascular outcomes (2019) (0)
Abstract 17979: A Genome-Wide Association Study of Risk of Coronary Artery Disease in European and South Asian Populations (2010) (0)
Functional analysis of the mutations in cardiac troponin I which cause familial hypertrophic cardiomyopathy (1999) (0)
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
Errata (2011) (0)
Whole-genome sequencing of patients with rare diseases in a national health system (2020) (0)
Distinct Subgroups in Hypertrophic Cardiomyopathy: Baseline Results From HCMR (2019) (0)
Abstract 16060: Familial Bicuspid Aortic Valve Disease Frequently Shows Discordance of Leaflet Fusion Pattern and Extent: Insights from Cardiovascular Magnetic Resonance (2012) (0)
Force, Ca-Sensitivity and Contractile Efficiency in Human Myocardium Expressing a Truncated Cardiac Myosin Binding Protein-C (2010) (0)
Direct Evidence In Man For Haploinsufficiency As The Mechanism Of Action Of Myosin-binding Protein C Mutations That Cause Hypertrophic Cardiomyopathy (2009) (0)
Evaluating drug targets through human loss-of-function genetic variation (2020) (0)
RAPID REPORT Cardiac Excitation and Contraction Mavacamten rescues increased myoﬁlament calcium sensitivity and dysregulation of Ca 2 (cid:2) ﬂux caused by thin ﬁlament hypertrophic cardiomyopathy mutations (2020) (0)
Functional polymorphism in matrix metalloproteinase-9 gene associated with coronary atherosclerosis (2000) (0)
Abstract 16702: Myocardial Deformation Analysis in Hypertrophic Cardiomyopathy With Sarcomere Mutations: Insights From 2,221 Patients Within the NHLBI-HCM Registry (2020) (0)
Mendelian randomization analysis of red cell distribution width in pulmonary arterial hypertension (2019) (0)
USE OF ENCODE DATA TO IDENTIFY PUTATIVE FUNCTIONAL VARIANTS IN CORONARY ARTERY DISEASE GWAS (2014) (0)
Small change, big impact: A Z-disc missense genetic variant causes dramatic morphological changes in the embryonic heart (2022) (0)
Resonance Imaging Left Ventricular Non-Compaction: Insights From Cardiovascular Magnetic (2011) (0)
Becker and Duchenne Muscular Dystrophy (BMD, DMD) are associated with myocardial fibrosis and abnormal cardiac energetics even in the presence of normal left ventricular ejection fraction (2010) (0)
The mutational constraint spectrum quantified from variation in 141,456 humans (2020) (0)
The genetic basis of variation in plasma fibrinogen and C-reactive protein levels (2000) (0)
Frank Ruschitzka : elected new President of the European Society of Cardiology Heart Failure Association 2016 – 18 (2015) (0)
Independent relevance of renal function for coronary artery disease (2010) (0)
The penetrance of rare variants in cardiomyopathy-associated genes: a cross-sectional approach to estimate penetrance for secondary findings (2023) (0)
Optimisation of Murine Cardiac Hyperpolarized Magnetic Resonance Spectroscopy Using Dynamic Nuclear Polarization (2010) (0)
Abstract 534: A Common Null Allele of LPA is Associated With Lp(a) Levels and Coronary Artery Disease Risk (2014) (0)
Augmented diastolic function in elite athletes measured by cine phase contrast velocity magnetic resonance Imaging (2005) (0)
evere Disease Expression of Cardiac roponin C and T Mutations in atients With Idiopathic Dilated Cardiomyopathy (2016) (0)
Functional analysis of a FLNC missense variant associated with hypertrophic cardiomyopathy (2022) (0)
In vivo assessment of cardiac metabolism and functional derangement in the spontaneously hypertensive rat heart using hyperpolarized magnetic resonance spectroscopy and CINE-MR imaging (2011) (0)
A novel truncated estrogen receptor alpha isoform in human endothelial cells: Potential relationship to surface-mediated estrogen responses (2001) (0)
Oxidized phospholipids, Lp(a) and coronary heart disease risk (2012) (0)
RNAseq reveals mechanisms of cardiomyopathy in Mlp-C58G knock-in mice (2018) (0)
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease (2018) (0)
Evaluation of Clinical Diagnostic Potential of Next Generation Sequencing using Hypertrophic Cardiomyopathy as a Model (2010) (0)
Genetic determinants of interventricular septal anatomy and the risk of ventricular septal defects and hypertrophic cardiomyopathy (2021) (0)
Investigation of troponin I mutations causing familial hypertrophic cardiomyopathy (2001) (0)
A troponin I mutant known to cause hypertrophic cardiomyopathy shows reduced inhibition of Ca2+ independent tension (2000) (0)
Early onset malignant hypertrophic cardiomyopathy caused by mutations in MYBPC3 (2003) (0)
Cardiac energetic impairment in non-obstructive hypertrophic cardiomyopathy: relation to exercise capacity and dynamic diastolic dysfunction (2009) (0)
Relationship between CMR and ECG-derived indices of left ventricular hypertrophy (2009) (0)
Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yield (2018) (0)
Association between the-174G/C polymorphism of the interleukin-6 gene and carotid atherosclerosis: Family study and meta-analysis (2005) (0)
Development and characterisation of a novel knock-in model of PRKAG2 cardiomyopathy (2009) (0)
Excretion of the urinary metabolite of deoxycortisol is heritable and influenced by polymorphic variation at the CYP11B2 (aldosterone synthase) locus (2003) (0)
Phosphorylation of HspB1 regulates its mechanosensitive molecular chaperone interaction with native filamin C (2018) (0)
Title : Hypertrophic Cardiomyopathy Mutations in MYBPC 3 Dysregulate Myosin : Implications for Therapy (2018) (0)
Nprl3 is required for normal development of the cardiovascular system (2012) (0)
Independent Relevance of Cytokines for Risk of Coronary Heart Disease (2012) (0)
389 Mutations in troponin and tropomyosin that cause familial dilated cardiomyopathy decrease crossbridge cycling speed and Ca2+‐sensitivity (2005) (0)
Inherited Cardiac Conditions - current issues and future directions (2009) (0)
Evaluation of polygenic score for hypertrophic cardiomyopathy in the general population and across clinical settings (2023) (0)
061 Metabolic alteration in hypertrophic cardiomyopathy (METAL-HCM Study): randomised double blinded placebo controlled trial of perhexiline therapy in patient with hypertrophic cardiomyopathy (2010) (0)
22 Impaired stress-induced oxygenation in hypertrophic cardiomyopathy is associated with an increased risk of ventricular arrhythmia (2019) (0)
Harnessing Genetics to Improve Cardiovascular Care (2011) (0)
83 The coronary artery disease associated gene JCAD regulates hippo signalling in endothelial cells (2018) (0)
Guanidinoacetate N-methyltransferase-knockout mice completely lacking myocardial phosphocreatine show normal in vivo cardiac function, but increased susceptibility to ischemia/reperfusion injury (2004) (0)
Novel mutations in cardiac MYPBC3 cause early onset malignant hypertrophic cardiomyopathy (HCM) (2005) (0)
University of Birmingham Mammalian 2 AMPK regulates intrinsic heart rate (2017) (0)
Cardiomyopathy-Causing Mutations in Thin Filament Regulatory Proteins Acutely Affeect Ca2+-Buffering and Ca2+-Dependent Signalling In Situ (2013) (0)
Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People (2009) (0)
Mutations in human cardiac myosin binding protein C cause late-onset familiar hypertrophic cardiomyopathy (1997) (0)
A rare variant of the leptin (LEP) gene has large effects on blood pressure (BP) and carotid intima-medial thickness (CIMT): Study of 1428 individuals in 248 families (2005) (0)
Manhattan++: displaying genome-wide association summary statistics with multiple annotation layers (2019) (0)
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy (2023) (0)
Abstract 3774: Reduced Hyperemic Myocardial Blood Flow in Hypertrophic Cardiomyopathy: New Insights from Multi-Parametric Magnetic Resonance Imaging (2006) (0)
Association between HSD11B1 polymorphism and left ventricular mass in families with hypertension (2009) (0)
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2020) (0)
Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin filament calcium binding (2007) (0)
Abstract 11789: Genetic Determinants of Interventricular Septal Anatomy and Risk of Congenital Heart Disease (2021) (0)
Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging (2011) (0)
Bicuspid Aortic Valve Disease Relatives Show No Evidence of an Inherited Aortopathy (2015) (0)
Association analyses based on false discovery rate implicate 243 susceptibility loci for coronary artery disease (2017) (0)
A fast-throughput service for Familial Hypertrophic and Dilated Cardiomyopathy using High resolution melt curve analysis on the Lightscanner (2007) (0)
P3 Novel insights into diminished cardiac reserve in hypertrophic cardiomyopathy from 4D flow CMR component analysis (2022) (0)
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2021) (0)
Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres (2002) (0)
Psychosocial and ethical issues in pre-symptomatic testing for Inherited Cardiac Conditions (ICCs) (2010) (0)
126 CHROMOSOME 9P21 LOCUS AND ANGIOGRAPHIC CORONARY ARTERY DISEASE BURDEN: A COLLABORATIVE META-ANALYSIS (2013) (0)
Mainstrearning genetics: Inherited cardiovascular disease as a model (2006) (0)
CHROMOSOME 9P21 LOCUS IS ASSOCIATED WITH VASCULAR STIFFNESS AND CDKN2A EXPRESSION IN HUMAN ARTERIES FROM PATIENTS UNDERGOING CORONARY ARTERY SURGERY (2010) (0)
109 The molecular phenotypes of HCM and DCM mutations depend on the ratio of mutant to wild type protein (2003) (0)
EXPRESSION AND FUNCTIONAL ASSESSMENT OF WILD-TYPE AND A HYPERTROPHIC CARDIOMYOPATHY MUTANT CARDIAC TROPONIN-T IN QUAIL MYOTUBES (1995) (0)
MANGANESE ENHANCED MRI CAN QUANTIFY MYOCARDIAL INFARCT SIZE EARLIER THAN GADOLINIUM ENHANCED MRI (2021) (0)
Evidence from a family based study of gene association of lymphotoxin alpha with coronary artery disease (CAD) (2004) (0)
P387Knock-in mouse model of PRKAG2 cardiomyopathy (R299Q) exhibits altered Ca2+-dependent cardiac contractility and reduced protein kinase A activity (2014) (0)
Abstract 15708: In Both Hypertrophic And Dilated Cardiomyopathy, Non-contrast T1 Mapping Provides Myocardial Tissue Characterization Beyond That Achieved By Late Gadolinium Enhancement. (2011) (0)
Abstract 442: Loss of Kiaa1462 , a Coronary Artery Disease Associated Gene, Decreases Atherosclerosis (2018) (0)
P7 LOSS OF KIAA1462, A CORONARY ARTERY DISEASE ASSOCIATED GENE, DECREASES ATHEROSCLEROSIS (2018) (0)
University of Dundee Genotype at the P554L Variant of the Hexose-6 Phosphate Dehydrogenase Gene Is Associated with Carotid Intima-Medial Thickness Rahman, (2011) (0)
Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes (2021) (0)
Autosomal dominant HCM and DCM phenotype caused by a novel mutation in phospholamban (2004) (0)
Expansion of a diagnostic service for hypertrophic cardiomyopathy using next generation sequencing (2011) (0)
Abstract 16339: Independent Relevance of Cytokines for Risk of Coronary Heart Disease (2012) (0)
Genetic basis of variation in fibrinogen and CRP (2000) (0)
Structure and organization of the human cardiac myosin binding protein-C gene enables analyses of familial hypertrophic cardiomyopathy mutations (1996) (0)
Investigating the Effect of Cardiomyopathy-Causing Mutations in Cardiac Troponin-T on Calcium Buffering In Situ (2010) (0)
In Memoriam (1973) (0)
Dilated cardiomyopathy causing mutations in cardiac troponin T (TNT), cardiac troponin C (TNC), and alpha tropomyosin (TM) reduce CA(2+) sensitivity and maximum calcium activation (2004) (0)
Abstract 16492: A Study of 63,253 Cases and 126,820 Controls Identifies Multiple Novel Loci for Coronary Artery Disease and Detects Independent Signals in Many of the Established Ones (2011) (0)
D Stress myocardial oxygenation and not perfusion reserve determines arrhythmic risk in hypertrophic cardiomyopathy: insights from a novel oxygen-sensitive CMR approach (2019) (0)
Supra-normal (phospho-)creatine levels lead to heart failure in mice overexpressing the cardiac creatine transporter - a longitudinal study (2006) (0)
Hypertrophic cardiomyopathy mutations increase myofilament Ca 2 (cid:2) buffering, alter intracellular Ca 2 (cid:2) handling, and stimulate Ca 2 (cid:2) -dependent signaling (2018) (0)
HCM and DCM mutations in cardiac thin filament proteins have opposite effects on the regulation of contractility in vitro (2003) (0)
Genetic variation at the CYP11B locus accounts for heritabilities of aldosterone excretion and 11-beta hydroxylase activity (2007) (0)
Cardiac Steatosis Detected in Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy and Aortic Stenosis (2011) (0)
Is the Myocardium Oxygen Deprived in Non Ischemic Heart Failure (2013) (0)
105 Distinctive troponin‐tropomyosin molecular phenotypes associated with acquired DCM, Familial DCM and familial HCM (2005) (0)
P123The rescue of Ca2+ cycling abnormalities conferred by HCM-causing mutations with analogues of the green tea polyphenol epigallocatechin-3-gallate (2014) (0)
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (0)
10 Impaired stress myocardial oxygenation precedes contractile abnormalities in three models of cardiac hypertrophy: insights from a novel oxygen sensitive cardiac magnetic resonance approach (2023) (0)
COMMON GENETIC VARIANTS ASSOCIATED WITH LOW Lp(a) KRINGLE-IV COPY NUMBER, HIGH Lp(a) CONCENTRATION, AND INCREASED RISK OF CORONARY HEART DISEASE (2010) (0)
UK GenetICC - Inherited Cardiac Conditions register (2011) (0)
Association of MARC1 A165T with metabolic traits. (2020) (0)
Response to letter regarding article, "myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy". (2013) (0)
Using CMR to improve the diagnostic accuracy of the ECG for the detection of left ventricular hypertrophy; production of a simple adjustment for body mass index (2016) (0)
Proteomic profiling identifies novel independent relationships between inflammatory proteins and myocardial infarction. (2023) (0)
Reduced twisting of the left ventricle in patients with symptomatic non-obstructive hypertrophic cardiomyopathy: A study using two-dimensional speckle tracking imaging (2008) (0)
Cortisol metabolite excretion and 11-hydroxysteroid dehydrogenase type 1 activity are strongly heritable in man (2003) (0)
Mechanisms for Phenotypic Variation in Hypertrophic Cardiomyopathy (2003) (0)
Altered inhibitory and troponin C-binding activities in cardiac troponin I mutants known to cause hypertrophic cardiomyopathy (2000) (0)
Autosomal dominant familial dilated cardiomyopathy caused by a novel mutation in phospholamban (2004) (0)
Impaired left ventricular energy metabolism in hypertrophic cardiomyopathy is not due to fibrosis. (2009) (0)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
Can Myocardial Ischaemia in Hypertrophic Cardiomyopathy be Assessed Non-invasively Without Radiation or Contrast Agents?: Role of Novel Adenosine Stress CMR T1 Mapping (2017) (0)
Addendum to Microvascular dysfunction in HCM 1 On-line addendum to “Evidence For Microvascular Dysfunction In Hypertrophic Cardiomyopathy – New Insights From Multi-Parametric Magnetic Resonance Imaging” (2007) (0)
6 Diffusion tensor magnetic resonance imaging of myocardial disarray in hypertrophic cardiomyopathy (2018) (0)
P3165Baseline characteristics of the hypertrophic cardiomyopathy registry (n=2773) (2018) (0)
GENETIC POLYMORPHISMS LINKED TO CORONARY ARTERY DISEASE ARE NOT ASSOCIATED WITH CAROTID ARTERY INTIMA-MEDIA THICKNESS, LEFT VENTRICULAR SIZE, OR INTERMEDIATE RISK PHENOTYPES (2009) (0)

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