Hugh Huxley
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English biologist
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Biology
Why Is Hugh Huxley Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hugh Esmor Huxley MBE FRS was a British molecular biologist who made important discoveries in the physiology of muscle. He was a graduate in physics from Christ's College, Cambridge. However, his education was interrupted for five years by the Second World War, during which he served in the Royal Air Force. His contribution to development of radar earned him an MBE.
Hugh Huxley's Published Works
Published Works
- Changes in the Cross-Striations of Muscle during Contraction and Stretch and their Structural Interpretation (1954) (1545)
- ELECTRON MICROSCOPE STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM STRIATED MUSCLE. (1963) (1414)
- The Mechanism of Muscular Contraction (1965) (1179)
- The low-angle x-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor. (1967) (1005)
- THE DOUBLE ARRAY OF FILAMENTS IN CROSS-STRIATED MUSCLE (1957) (582)
- Three-dimensional reconstruction of F-actin, thin filaments and decorated thin filaments. (1970) (537)
- Structural Changes in the Actin- and Myosin-eontaining Filaments during Contraction (1973) (529)
- X-ray diffraction measurements of the extensibility of actin and myosin filaments in contracting muscle. (1994) (454)
- The fine structure of the neuromuscular junction of the frog (1960) (377)
- PREFERENTIAL STAINING OF NUCLEIC ACID-CONTAINING STRUCTURES FOR ELECTRON MICROSCOPY (1961) (375)
- Electron microscope observations on the structure of microsomal particles from Escherichia coli (1960) (367)
- Structural Basis of the Cross-Striations in Muscle (1953) (343)
- FILAMENT LENGTHS IN STRIATED MUSCLE (1963) (339)
- Evidence for Continuity Between the Central Elements of the Triads and Extracellular Space in Frog Sartorius Muscle (1964) (327)
- Electron microscope studies of the organisation of the filaments in striated muscle. (1953) (293)
- X-ray evidence for radial cross-bridge movement and for the sliding filament model in actively contracting skeletal muscle. (1973) (269)
- Structural changes during activation of frog muscle studied by time-resolved X-ray diffraction. (1986) (268)
- Muscular Contraction and Cell Motility (1973) (245)
- Time-resolved X-ray diffraction studies of the myosin layer-line reflections during muscle contraction. (1982) (223)
- Structural difference between resting and rigor muscle; evidence from intensity changes in the lowangle equatorial x-ray diagram. (1968) (220)
- Three-dimensional image reconstruction of actin-tropomyosin complex and actin-tropomyosin-troponin T-troponin I complex. (1975) (215)
- Quatitative determination of myosin and actin in rabbit skeletal muscle (1983) (212)
- Regulation of skeletal muscle contraction. II. Structural studies of the interaction of the tropomyosin-troponin complex with actin. (1972) (211)
- Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications. (1983) (185)
- Quantitative studies on the structure of cross-striated myofibrils. I. Investigations by interference microscopy. (1957) (170)
- X-ray analysis and the problem of muscle (1953) (165)
- The osmotic properties of striated muscle fibres in hypertonic solutions (1963) (157)
- The use of synchrotron radiation in time-resolved X-ray diffraction studies of myosin layer-line reflections during muscle contraction (1980) (150)
- Sliding filaments and molecular motile systems. (1990) (144)
- Electron microscope observations on actomyosin and actin preparations from Physarum polycephalum, and on their interaction with heavy meromyosin subfragment I from muscle myosin. (1970) (135)
- Quantitative studies on the structure of cross-striated myofibrils. II. Investigations by biochemical techniques. (1957) (122)
- Fifty years of muscle and the sliding filament hypothesis. (2004) (120)
- Calcium sensitive binding of troponin to actin-tropomyosin: a two-site model for troponin action. (1973) (119)
- 7 – MOLECULAR BASIS OF CONTRACTION IN CROSS-STRIATED MUSCLES (1972) (116)
- Millisecond time-resolved changes in x-ray reflections from contracting muscle during rapid mechanical transients, recorded using synchrotron radiation. (1981) (108)
- Central core disease-an investigation of a rare muscle cell abnormality. (1961) (103)
- Ultrastructure of skeletal muscle fibers studied by a plunge quick freezing method: myofilament lengths. (1994) (102)
- The structure of the protein shell of turnip yellow mosaic virus (1960) (92)
- Crossbridge behaviour during muscle contraction (1985) (86)
- Structural evidence that myosin heads may interact with two sites on F-actin (1982) (79)
- Time-resolved X-ray diffraction studies on vertebrate striated muscle. (1983) (79)
- The Croonian Lecture, 1970 The structural basis of muscular contraction (1971) (76)
- OCCURRENCE AND FUNCTION OF POLYSOMES IN RABBIT RETICULOCYTES. (1964) (76)
- X-ray interference studies of crossbridge action in muscle contraction: evidence from quick releases. (2006) (72)
- The Contractile Structure of Cardiac and Skeletal Muscle (1961) (70)
- Constancy of Axial Spacings in Frog Sartorius Muscle during Contraction (1965) (65)
- ELECTRON MICROSCOPE STUDIES ON ULTRATHIN SECTIONS OF MUSCLE (1954) (57)
- Recent X-ray Diffraction and Electron Microscope Studies of Striated Muscle (1967) (56)
- The contraction of muscle. (1958) (55)
- The crossbridge mechanism of muscular contraction and its implications. (1985) (52)
- Progress in Biophysics and Molecular Biology (1985) (50)
- Structural arrangements and the contraction mechanism in striated muscle (1964) (47)
- A personal view of muscle and motility mechanisms. (1996) (45)
- X-ray interference studies of crossbridge action in muscle contraction: evidence from muscles during steady shortening. (2006) (44)
- Biophysics and Molecular Biology (1962) (43)
- Structure of Molluscan Tropomyosin (1957) (43)
- Structural changes during muscle contraction. (1971) (43)
- Cross-bridge movement during muscle contraction (1976) (41)
- THE STRUCTURAL BASIS OF THE CONTRACTION MECHANISM IN STRIATED MUSCLE (1959) (39)
- Discontinuous lattice changes in haemoglobin crystals (1953) (35)
- A SIMPLE NEW MICROTOME FOR ULTRATHIN SECTIONING (1954) (35)
- The role of the pinna in human localization * (2017) (35)
- Electron microscope observations on mitotic chromosomes. (1965) (33)
- X-Ray Diagrams from Skeletal Muscle in the Presence of ATP Analogs (1973) (31)
- The electron microscopy of unsectioned human chromosomes (1962) (30)
- Past, present and future experiments on muscle. (2000) (29)
- The design and use of a camera for low-angle X-ray diffraction experiments with synchrotron radiation (1977) (27)
- Memories of early work on muscle contraction and regulation in the 1950's and 1960's. (2008) (27)
- Recent X-ray diffraction studies of muscle contraction and their implications. (2004) (26)
- Muscle 1972: Progress and Problems (1973) (25)
- Chapter 1 – Molecular Basis of Contraction in Cross-Striated Muscles and Relevance to Motile Mechanisms in Other Cells (1983) (25)
- Development of Synchrotron Radiation as a High-Intensity Source for X-ray Diffraction. (1997) (23)
- New developments in electron microscopy (1971) (22)
- Time-resolved studies on contracting muscle using small-angle X-ray diffraction. I. Design of data collection system (1978) (18)
- Francis Crick: Hunter of Life's Secrets. (2010) (18)
- The structural basis of contraction and regulation in skeletal muscle. (1975) (18)
- The structural basis of muscular contraction. (1973) (16)
- Some aspects of staining of tissue for sectioning. (1958) (15)
- New X-Ray Evidence on the Configuration of Polypeptide Chins: Polypeptide Chains in Frog Sartorius Muscle (1951) (13)
- The Structure of Striated Muscle (1960) (13)
- The ultra-structure of striated muscle. (1956) (12)
- X-ray diffraction studies of the structural state of crossbridges in skinned frog sartorius muscle at low ionic strength (1987) (11)
- The Structural Basis of Contraction in Muscle and Its Study by Rapid X-Ray Diffraction Methods (1977) (11)
- Optimum geometric conditions in the design and use of X-ray diffraction tubes and cameras (1953) (11)
- X-ray interference evidence concerning the range of crossbridge movement, and backbone contributions to the meridional pattern. (2003) (11)
- The working stroke of myosin crossbridges. (1995) (10)
- The fine structure of striated muscle and its functional significance. (1966) (9)
- Extractability of the Lotmar–Picken Material from Dried Muscle (1952) (9)
- X-ray diffraction studies on muscle during rapid shortening and their implications concerning crossbridge behaviour. (1988) (8)
- A stopped-flow/rapid-freezing machine with millisecond time resolution to prepare intermediates in biochemical reactions for electron microscopy. (1990) (8)
- The effect of the ATP analogue AMPPNP on the structure of crossbridges in vertebrate skeletal muscles: X-ray diffraction and mechanical studies (1984) (8)
- The mechanism of muscular contraction. Science 164:1356-1366, 1969. (2002) (7)
- Spacing changes in the actin and myosin filaments during activation, and their implications. (1998) (7)
- Time-resolved X-ray diffraction studies of cross-bridge movement and their interpretation. (1984) (6)
- A Review of Techniques for Time-Resolved X-Ray Studies on Muscle (1981) (5)
- Evidence about the structural behaviour of myosin crossbridges during muscle contraction. (2007) (5)
- STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM MUSCLE (1962) (4)
- The design requirements of vertebrate striated muscle (1966) (4)
- Early developments in muscle research and the role of new structural technologies. (2005) (4)
- II. Some new developments in specimen preparation techniques. Introductory remarks (1971) (3)
- Getting to grips with contraction: the interplay of structure and biochemistry. (1998) (3)
- Time-resolved X-ray measurements on muscle using a fast multiwire linear detector (1991) (3)
- Recent applications of multiwire proportional chambers for time resolved studies on muscle (1986) (3)
- New X-ray Data about Myosin-binding Protein C in Frog Muscle (2009) (2)
- Polypeptide chains in frog sartorius muscle. (1951) (2)
- STRUCTURAL ASPECTS OF ENERGY CONVERSION IN MUSCLE (1974) (2)
- Obituary: Max Perutz (1914–2002) (2002) (2)
- Molecular biology of cell locomotion : proceedings of a Royal Society discussion meeting held on 24 and 25 March 1982 (1982) (2)
- Distribution of crossbridge states in contracting muscle. (2005) (2)
- I. New developments in instrumentation. Introductory remarks (1971) (1)
- STRUCTURAL ASPECTS OF CONTRACTION IN CARDIAC AND SKELETAL MUSCLE (1964) (1)
- Developments in X-ray technology and their contribution to structural biology. (1989) (1)
- The mechanism of muscular contraction. (2002) (1)
- Electron Microscope Studies on the Structure of Natural and Synthetic Protein Filaments from Striated Muscle (1989) (1)
- Past and Present Studies on the Interaction of Actin and Myosin (1977) (1)
- Introductory remarks on time resolved measurements (1982) (1)
- FIXATION, STAINING AND SECTIONING OF MITOTIC CHROMOSOMES FOR ELECTRON MICROSCOPY (1963) (1)
- Plunge Quick Freezing Method: Myofilament Lengths (2005) (0)
- * Publication hasbeensupported bytheNational Science Foundation. tResearch Professor, Australian-American Educational Foundation. Permanent address: (1966) (0)
- New Development in Electron Microscopy (1972) (0)
- Modeling the Working Stroke of the Muscle Crossbridges (2012) (0)
- Concluding remarks: progress in determining the detailed mechanism of muscle contraction. (2003) (0)
- Crick : Hunter of Life ’ s Secrets An intellectual biography by Robert Olby (2010) (0)
- How do crossbridges produce the sliding force between actin and myosin filaments in muscle (1987) (0)
- Progress in Biophysics and Molecular Biology, Volume 13 (1965) (0)
- Special talk: the beginning of low-angle X-ray diffraction work on living muscles. (2003) (0)
- Chapter 2 Birth of the Sliding Filament Model of Muscular Contraction : Proposal (2017) (0)
- Studies of structural changes during muscle contraction using synchrotron radiation (1986) (0)
- Corrigendum to “X-ray Interference Studies of Crossbridge Action in Muscle Contraction: Evidence from Muscles During Steady Shortening” [J. Mol. Biol. 363 (2006), 762–772] (2007) (0)
- Visualization in the EM of the intermediates in the actin-myosin ATPase cycle prepared by a rapid-freezing/stopped-flow method (1987) (0)
- A discussion on recent developments in vertebrate smooth muscle physiology: concluding remarks. (1973) (0)
- Biological Ultrastructure (1959) (0)
- THE WORKING STROKE OF MYOSIN CROSSBRIDGES. DISCUSSION (1995) (0)
- The mechanism of contraction (1960) (0)
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences: 359 (1452) (2004) (0)
- Advances in biophysics. Edited by Masao Kotani, 289 pp, Japan Scientific Societies Press, Tokyo, and University Park Press, Baltimore, MD, 1979. $39.50 (1982) (0)
- Positioning of Myosin-Binding Protein C in Skeletal Muscle (2010) (0)
- Huxley H E. Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle. J. Mol. Biol. 7:281-308, 1963 (2004) (0)
- THE REGULATION OF MUSCLE FUNCTION BY THE TROPOMYOSIN—TROPONIN SYSTEM (1976) (0)
- The Cavendish Laboratory and structural biology (2003) (0)
- Volume Information (1964) (0)
- Proceedings: Structural basis of contraction in muscle. (1975) (0)
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