Hugh McDevitt | Academic Influence

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Hugh McDevitt

Biology

#971

World Rank

#1686

Historical Rank

#516

USA Rank

Immunology

#44

World Rank

#48

Historical Rank

#16

USA Rank

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Biology

Hugh McDevitt's Degrees

PhD Immunology University of California, Berkeley
Bachelors Biology University of California, Berkeley

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Why Is Hugh McDevitt Influential?

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According to Wikipedia, Hugh O'Neill McDevitt ForMemRS was an immunologist and Professor of Microbiology and Immunology at Stanford University School of Medicine. Biography McDevitt was born in Ohio. His father was a surgeon and was Irish. After receiving his M.D. from Harvard University in 1955 and completing his residency in New York, McDevitt was a captain in the U.S. Army and a special fellow for the National Institutes of Medical Research in London.

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Hugh McDevitt's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. (1997) (2338)
HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus (1987) (1618)
In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes (2004) (1239)
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. (1995) (1220)
Insulin-Dependent Diabetes Mellitus (1996) (1168)
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice (1993) (1073)
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention (1988) (965)
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. (1990) (666)
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. (1987) (563)
Endotoxin-induced uveitis in rats as a model for human disease (1980) (538)
Autoimmune diseases: the failure of self tolerance. (1990) (482)
Genetic control of specific immune responses. (1969) (450)
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. (1987) (427)
HL-A, immune-response genes, and disease. (1974) (426)
Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type (1969) (414)
Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy (1989) (403)
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. (1994) (398)
In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon (1987) (393)
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. (1988) (376)
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. (1990) (368)
The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. (1996) (358)
Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease. (1971) (352)
CD8(+) T cell-mediated spontaneous diabetes in neonatal mice. (1996) (345)
GENETIC CONTROL OF THE ANTIBODY RESPONSE (1965) (345)
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process (1994) (339)
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes (1976) (328)
Two-gene control of the expression of a murine Ia antigen (1978) (325)
Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling (1997) (312)
A sequential model for peptide binding and transport by the transporters associated with antigen processing. (1994) (310)
GENETIC CONTROL OF THE IMMUNE RESPONSE (1972) (304)
Insulin-dependent diabetes mellitus: the initial lesion. (1981) (279)
CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. (1997) (273)
Tumor necrosis factor-α regulation of CD4+C25+ T cell levels in NOD mice (2002) (258)
Expansion of Functional Endogenous Antigen-Specific CD4+CD25+ Regulatory T Cells from Nonobese Diabetic Mice1 (2005) (255)
In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. (1981) (224)
Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis. (1988) (216)
Histocompatibility-linked immune response genes. (1972) (215)
GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE (1968) (215)
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. (1996) (215)
A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. (1988) (213)
Analysis of HLA-D region-associated molecules with monoclonal antibody. (1979) (211)
T cell recognition as the target for immune intervention in autoimmune disease (1989) (209)
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. (1983) (207)
Histocompatibility antigens, immune responsiveness and susceptibility to disease (1972) (203)
Allelic variation in the DR subregion of the human major histocompatibility complex. (1987) (199)
Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies (1983) (196)
Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates. (1979) (180)
Genetic control of the antibody response. II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A--L in CBA and C57 mice. (1967) (174)
Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. (1998) (169)
A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. (1991) (166)
Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. (1988) (166)
Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis [published erratum appears in J Exp Med 1988 Jul 1;168(1):455] (1988) (165)
In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor. (1983) (163)
Interferon-α initiates type 1 diabetes in nonobese diabetic mice (2008) (162)
Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis (1986) (157)
Regions of allelic hypervariability in the murine Aα immune response gene (1983) (155)
Genetic Control of Immune Responsiveness (1971) (150)
Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. (1977) (148)
Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors. (1993) (139)
Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein. (1996) (138)
Regulation of the immune response by the major histocompatibility system. (1980) (136)
T cell receptors in murine autoimmune diseases. (1989) (134)
The murine Eα immune response gene (1983) (134)
PURIFICATION AND ANALYSIS OF FLUORESCEIN-LABELED ANTISERA BY COLUMN CHROMATOGRAPHY. (1963) (132)
Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys. (1972) (129)
Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes (1976) (128)
Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. (2002) (127)
Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant (1984) (123)
An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. (1993) (122)
HLA-DQ BETA-CHAIN POLYMORPHISM LINKED TO MYASTHENIA GRAVIS (1986) (120)
Identification of stage-specific polypeptides synthesized during murine preimplantation development. (1978) (119)
Discovering the role of the major histocompatibility complex in the immune response. (2000) (117)
THE GENETIC CONTROL OF ANTIBODY SPECIFICITY (1969) (116)
Involvement of β7 Integrin and Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) in the Development of Diabetes in Nonobese Diabetic Mice (1997) (115)
The association between genes in the major histocompatibility complex and disease susceptibility,. (1977) (112)
Genetic control of the antibody response. 3. Qualitative and quantitative characterization of the antibody response to (T,G)-A--L in CBA and C57 mice. (1968) (111)
HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY: MURINE LYMPHOCYTIC CHORIOMENINGITIS VIRUS INJECTION (1973) (110)
Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus. (1990) (108)
GENETIC CONTROL OF THE IMMUNE RESPONSE (1974) (107)
A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice. (1994) (106)
The role of MHC class II molecules in susceptibility and resistance to autoimmunity. (1998) (105)
Antigen‐presenting cells in adoptively transferred and spontaneous autoimmune diabetes (1993) (101)
Heterogeneous effects of IFN-gamma in adjuvant arthritis. (1989) (100)
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire. (1999) (99)
Genomic polymorphism, recombination, and linkage disequilibrium in human major histocompatibility complex-encoded antigen-processing genes. (1992) (95)
Genetics and expression of mouse Ia antigens. (1985) (95)
Systemic antigen in the treatment of T-cell-mediated autoimmune diseases. (1997) (95)
The role of TNF-α in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation (2005) (94)
Multiple roles for tumor necrosis factor-α and lymphotoxin α/β in immunity and autoimmunity (2002) (92)
Adrenocortical steroid treatment of rheumatic diseases. Effects on lipid metabolism. (1973) (91)
THE NATURE OF THE ANTIGENIC DETERMINANT IN A GENETIC CONTROL OF THE ANTIBODY RESPONSE (1969) (91)
The LMP antigens: a stable MHC-controlled multisubunit protein complex. (1986) (90)
CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer (2002) (88)
Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones. (1986) (86)
A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis (1992) (85)
In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products. (1985) (84)
Identification of a fourth class of proteins linked to the murine major histocompatibility complex. (1982) (83)
A molecular basis for genetic susceptibility to insulin-dependent diabetes mellitus. (1988) (83)
GENETIC CONTROL OF THE ANTIBODY RESPONSE (1967) (82)
DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype. (1985) (82)
Identification of immunogenic epitopes of GAD 65 presented by A g7 in non-obese diabetic mice (1997) (78)
Induction of Apoptosis and T Helper 2 (Th2) Responses Correlates with Peptide Affinity for the Major Histocompatibility Complex in Self-reactive T Cell Receptor Transgenic Mice (1997) (75)
H–2-linked low-molecular weight polypeptide antigens assemble into an unusual macromolecular complex (1984) (73)
The role of TNFα and related cytokines in the development and function of the autoreactive T-cell repertoire (1997) (73)
Antigen binding T and B lymphocytes. I. Differences in cellular specificity and influence of metabolic activity on interaction of antigen with T and B cells. (1974) (72)
Quantitative Analysis of Peptides from Myelin Basic Protein Binding to the MHC Class II Protein, I-Au, Which Confers Susceptibility to Experimental Allergic Encephalomyelitis (1996) (70)
Cyclophosphamide therapy in systemic lupus erythematosus and polymyositis. (1973) (70)
Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: implications in induction of autoimmunity. (1994) (69)
Prevention of diabetes in NOD mice by a mutated I-Ab transgene. (1998) (68)
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes (2006) (66)
HLA-DR2 subtypes form an additional supertypic family of DR beta alleles. (1987) (65)
Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development. (1998) (64)
Administering glutamic acid decarboxylase to NOD mice prevents diabetes. (1994) (63)
Treatment of NZB/NZW F1 hybrid mice with Mycobacterium bovis strain BCG or type II interferon preparations accelerates autoimmune disease. (1981) (63)
The Role of Cell Adhesion Molecules in the Development of IDDM: Implications for Pathogenesis and Therapy (1996) (63)
Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide (1981) (63)
A suppressor T cell of the mixed lymphocyte reaction in man specific for the stimulating alloantigen. Evidence that identity at HLA-D between suppressor and responder is required for suppression (1978) (63)
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus (2003) (62)
A sensitive radioimmunoassay for detecting products translated from cloned DNA fragments (1978) (61)
The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology. (1983) (60)
Structure of murine Ia antigens: partial NH2-terminal amino acid sequences of products of the I-E or I-C subregion. (1977) (60)
Major Histocompatibility Complex–Encoded Antigen Processing Gene Polymorphism in IDDM (1994) (60)
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO POLY-L(TYR,GLU)-POLY-D,L-ALA--POLY-L-LYS IN C3H↔CWB TETRAPARENTAL MICE (1974) (59)
Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain. (1983) (58)
A Critical Role for Lymphotoxin-β Receptor in the Development of Diabetes in Nonobese Diabetic Mice (2001) (58)
The role of TNF-alpha in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: analysis of dendritic cell maturation. (2005) (57)
The Fc receptor on thymus-derived lymphocytes. IV. Inhibition of binding of antigen-antibody complexes to Fc receptor-positive T cells by anti-Ia sera (1977) (57)
Specific antigen vaccination to treat autoimmune disease (2004) (57)
Redirecting Th1 and Th2 responses in autoimmune disease. (1999) (55)
Antigen binding T and B lymphocytes. II. Studies on the inhibition of antigen binding to T and B cells by anti-immunoglobulin and anti-H-2 sera. (1974) (55)
Isolation of Nonobese Diabetic Mouse T-Cells That Recognize Novel Autoantigens Involved in the Early Events of Diabetes (1994) (54)
Rheumatoid arthritis and its animal models: the role of TNF-alpha and the possible absence of specific immune reactions. (1999) (53)
Molecular mapping of class II polymorphisms in the human major histocompatibility complex. I. DR beta. (1987) (53)
In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A (1981) (53)
Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients. (1986) (52)
Interaction between I region loci influences the expression of a cell surface Ia antigen. (1980) (52)
Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity? (1994) (51)
Inhibition of experimental autoimmune encephalomyelitis by a nonimmunogenic non-self peptide that binds to I-Au. (1992) (50)
Involvement of beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice. (1997) (50)
Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans. (1992) (50)
The role of interferon alpha in initiation of type I diabetes in the NOD mouse. (2011) (49)
Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development. (1992) (49)
Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens (1985) (49)
Expression of Ia antigens on hapten-specific B cells. I. Delineation of B-cell subpopulations (1976) (48)
Genetic control of the immune response. Frequency and characteristics of antigen-binding cells in high and low responder mice. (1973) (48)
I-REGION GENES ARE EXPRESSED ON T AND B LYMPHOCYTES (1974) (48)
The molecular basis of HLA-disease association. (1989) (47)
Peptide map analyses of murine Ia antigens of the I–E subregion using HPLC (1979) (47)
Antigen processing gene polymorphisms in HLA‐DR2 multiple sclerosis (1993) (46)
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype. (2006) (46)
DR, DQ, and you: MHC alleles and autoimmunity. (2001) (45)
Filter affinity transfer. A new technique for the in situ identification of proteins in gels. (1979) (45)
The search for a human equivalent of the mouse T-locus - negative results from a study of HL-A types in spina bifida. (1975) (44)
THE ROLE OF H‐2 I REGION GENES IN REGULATION OF THE IMMUNE RESPONSE * (1981) (43)
Genetic control of immune responsiveness : relationship to disease susceptibility (1972) (43)
GENETIC CONTROL OF THE IMMUNE RESPONSE : In Vitro Stimulation of Lymphocytes by (T,G)-A--L, (H,G)-A--L, and (Phe,G)-A--L (1974) (42)
Monoclonal antibodies reacting with murine teratocarcinoma cells. (1979) (40)
G E N E T I C CONTROL OF T H E ANTIBODY RESPONSE I. DEMONSTRATION OF DETERMINANT-SPECIFIC DIFFERENCES IN RESPONSE TO SYNTHETIC POLYPEPTIDE ANTIGENS IN TWO STRAINS OF INBRED MICE (2003) (39)
Tissue distribution of ia antigens: Ia on spermatozoa, macrophages, and epidermal cells (1974) (38)
Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator (1978) (37)
Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells. (2004) (37)
Ia antigens on alloreactive T cells in man detected by monoclonal antibodies. Evidence for synthesis of HLA-D/DR molecules of the responder type. (1980) (37)
Immune deficiency due to high copy numbers of an Ak beta transgene. (1990) (37)
B lymphocyte alloantigens controlled by theI region of the major histocompatibility complex in mice (1974) (37)
Closing in on type 1 diabetes. (2001) (37)
Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones. (1985) (36)
A suppressor T cell of the mixed lymphocyte reaction specific for the HLA-D region in man. (1978) (36)
Binding of an invariant-chain peptide, CLIP, to I-A major histocompatibility complex class II molecules. (1995) (36)
HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY (1973) (36)
Prevention of insulin-dependent diabetes mellitus in nonobese diabetic mice by immunogenic but not by tolerated peptides (1995) (35)
Characterization of HLA-D-region antigens by two-dimensional gel electrophoresis. Molecular-genotyping. (1980) (35)
Murine model for pertussis vaccine encephalopathy: linkage to H–2 (1982) (34)
Genetic control of cell-mediated responsiveness to an AKR tumor- associated antigen: mapping of the locus involved to the I region of the H-2 complex (1977) (34)
Antigen Recognition and Peptide‐Mediated Immunotherapy in Autoimmune Disease (1990) (34)
Major histocompatibility complex associations with systemic lupus erythematosus. (1988) (33)
HLA antigens and insulin-dependent diabetes (1988) (33)
Selective expression of separate I-region loci in functionally different lymphocyte subpopulations. (1977) (33)
Genetic control of the immune response to (T,G)-A--L in C3H ↔ C57 tetraparental mice (1974) (33)
Histocompatibility‐Linked Genetic Control of Specific Immune Responses to Viral Infection (1974) (33)
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes. (1981) (32)
The association between the HLA system and disease. (1977) (32)
High‐Dose Soluble Antigen: Peripheral T‐Cell Proliferation or Apoptosis (1994) (32)
Identification of autoantigen epitopes in MHC Class II transgenic mice (1998) (31)
Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model. (2005) (31)
The HLA system and its relation to disease. (1985) (30)
The immunogenetics of rheumatic diseases. (1988) (29)
Genetic nomenclature for theH-2 complex of the mouse (1974) (29)
Mixed lymphocyte reaction in healthy women with rheumatoid factor. Lack of association with HLA-Dw4. (1978) (29)
E alpha u and E beta u chain association: where lies the anomaly? (1986) (29)
Expression of murine Ia antigens during embryonic development. (1978) (29)
Genetic control of the antibody response to a synthetic polypeptide: transfer of response with spleen cells or lymphoid precursors. (1969) (28)
Molecular mapping class II polymoprhisms in the human major histocompatibility complex. II: DQβ (1987) (28)
Immunological detection and characterization of products translated from cloned DNA fragments. (1979) (26)
FUNCTIONAL ANALYSIS OF Ia ANTIGENS IN RELATION TO GENETIC CONTROL OF THE IMMUNE RESPONSE (1976) (26)
Presence of circulating immune complexes in Reiter's syndrome and ankylosing spondylitis (1981) (26)
Molecular analysis of the HLA-DRB genes in two tribes of Brazilian Indians. (1994) (26)
IDENTIFICATION OF SEPARATE I REGION PRODUCTS BY TWO-DIMENSIONAL ELECTROPHORESIS (1978) (25)
Evolution of MHC Class II Allelic Diversity (1995) (25)
Variable synthesis and expression of Eβ and Ae (Eβ) Ia polypeptide chains in mice of differentH-2 haplotypes (2005) (25)
Regions of allelic hypervariability in the murine A alpha immune response gene. (1983) (25)
Ir GENES AND ANTIGEN RECOGNITION1 (1974) (24)
Monoclonal anti-Ia antibody therapy in animal models of autoimmune disease. (1987) (24)
Genomic expression profiling of TNF-α-treated BDC2.5 diabetogenic CD4+ T cells (2008) (24)
COMPARATIVE ANALYSIS OF ANTIGEN-BINDING T CELLS IN GENETIC HIGH AND LOW RESPONDER MICE (1974) (24)
MHC class II-associated variation in the production of tumor necrosis factor in mice and humans: Relevance to the pathogenesis of autoimmune diseases (1991) (23)
Murine t factors: an association between alleles at t and at H-2 (1976) (23)
HLA-D antigens in the Japanese population. (2008) (23)
Acquired type 3 hyperlipoproteinemia. Report of three cases associated with systemic lupus erythematosus and diabetic ketoacidosis. (1972) (23)
Partial N‐terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I‐A subregion (1979) (22)
Antibody response of C3H in equilibrium (CKB X CWB)F1 tetraparental mice to poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys immunization (1976) (21)
Biochemical characterization of an invariant polypeptide associated with Ia antigens in human and mouse. (1983) (21)
HLA-B locus polymorphism: studies with a specific hybridization probe. (1985) (20)
The role of class II molecules in development of insulin-dependent diabetes mellitus in mice, rats and humans. (1990) (20)
Delineation of the subunit composition of human proteasomes using antisera against the major histocompatibility complex-encoded LMP2 and LMP7 subunits. (1994) (20)
The expression of i-region gene products on lymphocytes. II. Genetic localization and cellular distribution of mlr determinants. (1977) (20)
Immunochemical evidence for three Ia loci in the I-region of the H-2 complex (1977) (20)
Role of TNF-alpha in the development of autoimmunity and the pathogenesis of insulin-dependent diabetes mellitus in NOD mice. (1994) (20)
Genetic control of the antibody response in inbred mice: transfer of respone by spleen cells and linkage to the major histocompatibility [H-2] locus. USNRDL-TR-68-16. (1968) (19)
The role of MHC class II genes in susceptibility and resistance to type I diabetes mellitus in the NOD mouse. (1996) (19)
The murine E alpha immune response gene. (1983) (19)
The role of TNF alpha and related cytokines in the development and function of the autoreactive T-cell repertoire. (1997) (19)
The discovery of linkage between the MHC and genetic control of the immune response (2002) (19)
Reduction in Diabetes Incidence in an I-Ag7 Transgenic Nonobese Diabetic Mouse Line (1997) (19)
Characteristics of autoimmunity in type 1 diabetes and type 1.5 overlap with type 2 diabetes. (2005) (18)
High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism. (1996) (18)
Antibody responses to two synthetic polypeptides: the role of the thymic epithelial reticulum. (1970) (17)
A small number of residues in the class II molecule I-Au confer the ability to bind the myelin basic protein peptide Ac1-11. (1999) (17)
Autoimmune diabetes mellitus--much progress, but many challenges. (2008) (17)
Binding of a polypeptide antigen to ribonucleic acid from macrophage, HeLa and Escherichia coli cells. (1971) (17)
GENETIC CONTROL OF SPECIFIC IMMUNE RESPONSES IN INBRED MICE * (1971) (16)
Molecular characterization of MHC class II antigens (β1 domain) in the BB diabetes-prone and -resistant rat (2004) (16)
Transgenic mice expressing surface markers for IFN-γ and IL-4 producing cells. (2000) (16)
Immunology and genetics. (1972) (16)
Analysis of anti-sperm sera for T/t locus-specific antibody. (1979) (16)
Faculty Opinions recommendation of Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. (2001) (16)
Use of high dose X-irradiation to block back stimulation in the MLC reaction. (2008) (16)
Assay for antibody mediated cytotoxicity of mouse spermatozoa by 86rubidium release. (2008) (15)
Induction of Apoptosis and T Helper 2 ( Th 2 ) Responses Correlates with Peptide Affinity for the Major Histocompatibility Complex in Self-reactive T Cell Receptor Transgenic Mice (1997) (15)
No direct association between Ia antigens and Fc receptors on the B cell membrane. (1977) (14)
PARTIAL AMINO ACID SEQUENCE ANALYSES OF Ia MOLECULES (1978) (14)
An immune response defect due to low levels of class II cell surface expression. Analysis of antigen presentation and positive selection. (1991) (14)
Analysis of anti-(T,G)-A--L antibody in tetraparental mice. (1973) (14)
Functional and genetic analysis of Ia antigens. (1977) (13)
Mapping of the genetic control of murine response to low doses of the dinitrophenyl conjugates of ovomucoid and bovine gamma-globulin. (1976) (13)
The role of MHC class II molecules in the pathogenesis and prevention of Type I diabetes. (2001) (13)
Therapy of Autoimmune Diseases with Antibody to Immune Response Gene Products or to T‐Cell Surface Markers a (1986) (13)
Isolation and characterization of murine Ia antigens (1975) (13)
Cell adhesion molecules: a selective therapeutic target for alleviation of IDDM. (1994) (13)
PREDOMINANT EXPRESSION OF A T CELL RECEPTOR V,6 GENE SUBFAMILY IN AUTOIMMUNE ENCEPHALOMYELITIS (2003) (12)
A rare HLA DQB allele sequenced from patients with systemic lupus erythematosus. (1991) (12)
Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein. (1989) (12)
HLA‐DR restriction‐fragment‐length polymorphisms in narcolepsy (1987) (11)
The effect of genetic control of immune response to synthetic polypeptides on the response to homologous DNP-polypeptide conjugates. (1967) (11)
Inhibition of Specific Effector T Cell-Target Cell Conjugates by Target Cell Plasma Membranes (1978) (11)
Genetic control of the immune response: ability of antigens of defined amino acid sequence to be recognized by the Ir‐1 gene system (1976) (10)
Genetic control of immune response in mice to derivatives of multichain polyproline differing in the optical configuration of component amino acids (1973) (10)
Idiotypic characteristics of immunoglobulins associated with human systemic lupus erythematosus. Association of high serum levels of IdGN2 with nephritis but not with HLA class II genes predisposing to nephritis. (1990) (10)
The immune response to diphtheria toxoid in humans. (1977) (10)
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice (1994) (10)
A new model for rheumatoid arthritis? (2000) (10)
Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis (1991) (10)
EAE: a model for immune intervention with synthetic peptides. (1992) (10)
HLA‐DQ Restriction Fragment Length Polymorphisms in Myasthenia Gravis a (1987) (9)
An HLA-D specificity found in the Japanese population. (2008) (9)
The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo. (1990) (9)
Structural similarity between a primitive chordate membrane heterodimer and lymphocyte antigen receptors. (1990) (9)
Host Genes Controlling the Immune Response (1984) (9)
The role of polymorphic I-Ak beta chain residues in presentation of a peptide from myelin basic protein (1989) (9)
Selection of Aberrant Class II Restricted CD8+ T Cells in NOD Mice Expressing a Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgene (2004) (8)
Use of synthetic oligonucleotide probes complementary to genes for human HLA-DR alpha and beta as extension primers for the isolation of 5'-specific genomic clones. (1983) (8)
Partial amino acid sequences of marine Ia antigens of the I-ECd subregion (1978) (8)
T cell recognition in experimental autoimmune encephalomyelitis: prospects for immune intervention with synthetic peptides. (1990) (8)
Structural and functional variability among DQβ alleles of DR2 subtypes (2004) (8)
Induction of a heterogeneous TCR repertoire in (PL/JXSJL/J)F1 mice by myelin basic protein peptide Ac1-11 and its analog Ac1-11[4A]. (1997) (8)
Effect of Tumor Necrosis Factor o ~ on Insulin-dependent Diabetes Mellitus in NOD Mice (2003) (8)
GENETIC CONTROL OF THE IMMUNE RESPONSE (1972) (7)
A Study of HLA-B-Locus Polymorphism with a Specific Hybridization Probe (1984) (7)
Histocompatibility-linked genetic control of specific immune responses. (1974) (7)
Molecular Structure of Human Class II Antigens (1989) (7)
The molecular basis of autoimmunity. (1986) (7)
Evolution, function, and utilization of major histocompatibility complex polymorphism in autoimmune disease. (1989) (7)
Genetic considerations in atopic and other dermatologic conditions. (1976) (6)
Restriction fragment length polymorphism in canine narcolepsy (2004) (6)
Revised nomenclature of mouseH-2 genes (2005) (6)
ANTIBODY RESPONSE OF C3H ~ (CKB × CWB)F1 TETRAPARENTAL MICE TO POLY-L(TYR,GLU)-POLY-D, L-ALA--POLY-L-LYS IMMUNIZATION* (2003) (6)
Nature of the Responding Organism: Responders and Nonresponders (1973) (6)
Structural and functional variability among DQ beta alleles of DR2 subtypes. (1987) (6)
INHIBITORY EFFECT OF ANTI-Ia SERA ON PROLIFERATIVE RESPONSES TO (H,G)-A--L and (Phe,G)-A--L (1978) (5)
Molecular Genetics of Class II (Ia) Antigens (1987) (5)
The expression of I-region gene products on lymphocytes (1977) (5)
Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP) (1983) (5)
DNA sequence and characterization of human class II major histocompatibility complex 8 chains from the DRI haplotype (5)
Molecular mapping class II polymorphisms in the human major histocompatibility complex. II. DQ beta. (1987) (5)
METHODS FOR PREPARATION OF FLUORESCENT PROTEINS. (1964) (4)
Autoimmune diabetes and its antigenic triggers. (1995) (4)
Ir associated antigens (1975) (4)
HLA-DR2 and the Narcolepsy Syndrome: The Stanford Experience (1988) (4)
Absence of Polymorphism between DR and DQ Sequences Isolated from Celiac Disease Patients and Normals (1989) (4)
Prevention of EAE with monoclonal anti-I-A antibodies. (1981) (4)
The genetics of the HLA system. (1983) (4)
The T Cell Response to Glutamic Acid Decarboxylase 65 in T Cell Receptor Transgenic NOD Mice (2003) (3)
The evolution of genes in the major histocompatibility complex. (1976) (3)
Frequency and characteristics of antigen binding cells in genetic high and low responder mice. (1973) (3)
SEROLOGICAL ANALYSIS OF RECOMBINANT STRAIN A.TFR5 (1978) (3)
Expression of Ia Antigens on T Lymphocytes (1980) (3)
Perspectives on the molecular biology and immunology of the pancreatic β cell (1989) (3)
GENETIC CONTROL OF THE IMMUNE RESPONSE: Relationship between the Immune Response-1 Gene(s) and Individual H-2 Antigenic Specificities (1972) (3)
Insulin-Dependent Diabetes Mellitus Review (1996) (3)
Genetic Control of the Antibody Response: Genetic Mapping Studies of the Linkage Between the H-2 and Ir-1 loci1 (1971) (3)
Further characterization of endotoxin induced uveitis (1980) (3)
Molecular biology of the class II region of the human major histocompatibility complex. (1986) (3)
Genetic control of the immune response to (T,G)-A--L in C3H in equilibrium C57 tetraparental mice. (1974) (2)
Transgenic mice expressing surface markers for IFN-gamma and IL-4 producing cells. (2000) (2)
In vivo effects of antibodies to immune response gene products. II. Suppression of humoral immune responses with monoclonal anti-I-A is due to suppressor cells. (1988) (2)
Genetic Control of Immune Responsiveness: Summary of Contributions by Discussants (1971) (2)
EVIDENCE FOR THE ASSOCIATION OF SPECIFICITY Ia.3 WITH AN I-A REGION MOLECULE (1976) (2)
The nature and site of action of the Ir-1 gene. (1974) (2)
Speculations on how Ia antigens (Ir genes) influence the specificity of the immune response. (1984) (2)
LYMPHOSCINTIGRAPHY WITH IN‐111 LABELED MONOCLONAL ANTIBODIES: A4 (1983) (2)
IR-1A GENE INFLUENCE ON CHIMERIC LYMPHOID CELL INTERACTIONS (1978) (2)
Prevention of Diabetes in NOD Mice by a Mutated I-Ab Tr a n s g e n e (1998) (2)
Immunopathogenesis of type 1 diabetes mellitus (2008) (2)
Ir genes: towards the year 2000. (1991) (2)
Selective targets for immunotherapy in autoimmune disease. (1995) (2)
The HLA-DQB1 Gene Contributes to the Genetic Susceptibility to Insulin-Dependent Diabetes Mellitus (1989) (2)
T cell receptors in autoimmune disease as targets for immune intervention. (1989) (2)
Ir genes and Ia antigens: Proceedings of the third Ir Gene Workshop held at Asilomar, California, December 13-16, 1976 (1978) (2)
Chemical Characterization of Murine Ia Antigens (1978) (2)
NO LINKAGE OR ASSOCIATION OF TELOMERIC AND CENTROMERIC T‐CELL RECEPTOR β‐CHAIN MARKERS WITH SUSCEPTIBILITY TO TYPE 1 INSULIN‐DEPENDENT DIABETES IN HLA‐DR4 MULTIPLEX FAMILIES (1996) (2)
Fundamental characteristics of histocompatibility-linked specific immune-response (Ir) genes. (1973) (1)
MURINE t FACTORS: AN ASSOCIATION BETWEEN ALLELES (1976) (1)
H-2 LINKED REGULATION OF CELL-MEDIATED RESPONSIVENESS TO AN AKR TUMOR ASSOCIATED ANTIGEN (1978) (1)
Dissecting T cell responses to cartilage antigens in HLA class II transgenic mice. (1998) (1)
Presence of circulation immune complexes in Reiter's syndrome and ankylosing spondylitis. (1981) (1)
A late relapse of Wegener granulomatosis. (1990) (1)
Evolution of the histocompatibility complex: Cloning and analysis of MHC related sequences in the colonial tunicate Botryllus sp. Monterey and the trout Salmo gairdneri (1986) (1)
Cells from Nonobese Diabetic Mice Regulatory T + CD25 + Antigen-Specific CD4 Expansion of Functional Endogenous (2017) (1)
Fluorescence-Activated Cell Sorter Analysis of Peptide–Major Histocompatibility Complex (1993) (1)
The cellular localization of antigen. (1968) (1)
Genetic control of the antibody responses: relationship between immune response and histocompatibility (H-2) type. 1969. (2004) (1)
Role of MHC Polymorphism in Autoimmune Disease (1989) (1)
Characterization of HLA-DRβ and HLA DQβ Alleles Associated with Pemphigus Vulgaris (1989) (1)
Quantitative Differences in the Expression of Specificity Ia.7 (1978) (1)
Protein clinical manifestations of primary tumors of the heart. (1972) (1)
The murine Ia a chains , E . and A . , show a surprising degree of sequence homology ( Ia antigens / major histocompatibility complex / immune-response genes / recombinant DNA / DNA sequence analysis ) CHRISTOPHE 0 (1)
Faculty Opinions recommendation of Integrin-mediated long-term B cell retention in the splenic marginal zone. (2002) (1)
GENETIC CONTROL OF IMMUNOCOMPETENT CELL INTERACTIONS (1975) (1)
Structure, regulatory polymorphisms, and allelic hypervariability regions in murine I-A alpha. (1984) (1)
Pillars Article: Genetic Control of the Antibody Responses: Relationship between Immune Response and Histocompatibility (H-2) Type. Science, 1969, 163 :1207–1208. (2004) (1)
EXPRESSION OF AN I REGION LOCUS IN HELPER T LYMPHOCYTES (1978) (1)
The genetic control of immune responses. (1981) (1)
Genetic Control of the Immune Response to Multichain Synthetic Polypeptides (1970) (1)
Molecular Polymorphism of Human Immune-Response-Genes (1986) (1)
Antigen-binding structures on the surface of T lymphocytes. (1975) (1)
The Effect of Copy Number on mRNA and Cell Surface Expression of an Aβk Transgene (1990) (0)
GENETIC CONTROL OF THE IMMUNE RESPONSE (1973) (0)
Molecular studies of human hla d region associated antigens (1980) (0)
GENERAL DISCUSSION - SESSION III: MECHANISMS OF B CELL TOLERANCE (1974) (0)
The expression ofI-region gene products on lymphocytes (2005) (0)
Structure and Expression of the Murine Ia α Chains (1983) (0)
T CELL RECEPTORS IN (1989) (0)
Experimental Medicine Edited by R Recognition of Viral Glycoproteins by Influenza Α-specific Cross-reactive Cytolytic Τ Lymphocytes* Materials and Methods (0)
Antigen Binding T and B Lymphocytes (1974) (0)
Inhibition of Adoptive Transfer and Development of Spontaneous Diabetes mellitus in Nonobese Diabetic Mice by TNF-α (1990) (0)
Cell Plasma Membranes Cell-Target Cell Conjugates by Target Inhibition of Specific Effector T (2010) (0)
F.31. L-Type Voltage-Gated Ca2+ Channels in CD4+ T-Cells (2006) (0)
Reply from Liblau, Singer and McDevitt (1995) (0)
Modification of endo toxin induced uveitis by cortico steroids and nonsteroidal anti inflammatory drugs (1980) (0)
Ir genes--forty years on. (2004) (0)
The Effect of Tumor Necrosis Factor (TNF) on (NZB × NZW)F1 Lupus Nephritis (1989) (0)
A new set of polymorphic proteins linked to the mouse major histocompatibility complex. Abstr. (1982) (0)
Molecular mimicry in EAE (1998) (0)
GENETIC CONTROL OF T H E ANTIBODY RESPONSE IN INBRED MICE TRANSFER OF RESPONSE BY SPLEEN CELLS AND LINKAGE TO THE MAJOR (2003) (0)
Method for controlling self-immune disease relating to mhc using antagonistic substance to interferon gamma (1988) (0)
IMMUNOREGULATORY APPROACHES TO TREATMENT - FINAL GENERAL DISCUSSION (1987) (0)
Peptide Motif II Molecule Identifies an Immunogenic Type I Diabetes-Associated HLA-DQ 8 Class Decarboxylase 65 Peptides Presented by the Determination of Glutamic Acid (1999) (0)
A relative risk of 107 for IDDM is conferred to non-Asp 57 homozygotes (1990) (0)
Therapeutic intervention in autoimmunity. (1994) (0)
Association of DPB1 genes with systemic lupus erythematosus. (1997) (0)
Fifteenth midwinter conference of immunologists: lymphocyte differentiation. (1976) (0)
The Molecular Mechanisms of HLA Associated Autoimmunity (1993) (0)
Systemic corticosteroid therapy in rheumatic diseases. (1972) (0)
Genetic control of the immune response to synthetic antigens (1973) (0)
Structure/Function Relationships Among Murine Class II Molecules: Sequence Analysis of I-A cDNA Clones (1986) (0)
Nomenclature Revised nomenclature of mouse B-2 genes (1993) (0)
4 – Allelic Polymorphism of HLA Class II Antigens: Clues to the Molecular Basis of Autoimmunity (1990) (0)
Faculty Opinions recommendation of Distinct recognition by two subsets of T cells of an MHC class II-peptide complex. (2002) (0)
The role of TNF- (cid:1) in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation (2005) (0)
Inhibition of specific effector T cell-target cell conjugates by cell plasma membranes. (1978) (0)
Faculty Opinions recommendation of A chemokine-driven positive feedback loop organizes lymphoid follicles. (2001) (0)
EVIDENCE FOR THE PRESENCE OF AN Ia MOLECULE DETERMINED BY EACH OF THE Ia-3 and Ia-5 LOCI (1978) (0)
T.126. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA (2009) (0)
GENETIC CONTROL OF THE IMMUNE RESPONSE In Vitro Stimulation of Lymphocytes by ( T , G )-A-- L , ( H , G )-A-- L , and ( Phe (2003) (0)
OR.23. Interferon Alpha Initiates Type 1 Diabetes in NOD Mice (2008) (0)
Immunology of Insulin-Dependent Diabetes Mellitus (2020) (0)
I-region genes in mouse and man. (1983) (0)
F.58. Role of Plasmacytoid Dendritic Cells in the Initiation of Type I Diabetes in NOD Mice (2009) (0)
THE NATURE OF AUTOIMMUNE-DISEASE - GENERAL DISCUSSION (1987) (0)
International Symposium on Hodgkin's disease. Session 1. Epidemiology and etiology. Part 3. Immunology. Invited discussion: Genetic factors in immune responsivess. (1973) (0)
Autoreactive Cloned T Cell Lines in Murine Insulin-Dependent Diabetes Mellitus (1990) (0)
Presence of a Non-polymorphic Polypeptide Chain in Ia Immunoprecipitates (1978) (0)
Administration form for an antagonist of gamma-interferon for the control of a GHK-associated autoimmune disease. (1988) (0)
T cell receptor and autoimmune disease. (1990) (0)
expresses a down-regulatory T helper 2 phenotype DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope (2006) (0)
The role of MHC-encoded low molecular weight proteins in antigen processing (1993) (0)
Peptide epitopes of glutamic acid decarboxylase 65 presented by I-Ag7 and I-Ag7,PD (2009) (0)
Brief Definitive Report IN VIVO TREATMENT OF ( NZB X NZW ) F , LUPUS-LIKE NEPHRITIS WITH MONOCLONAL ANTIBODY TOy INTERFERON BY (2003) (0)
CHAIRMAN'S SUMMARY: SELECTED EXPRESSION OF I REGION GENE PRODUCTS IN FUNCTIONALLY DISTINCT IMMUNOCOMPETENT CELL POPULATIONS (1978) (0)
Ia ANTIGENS ON FcR POSITIVE T LYMPHOCYTES (1978) (0)
Autoimmunity: 2000 and Beyond, Newport Beach, California, February 11–13, 2000 (2004) (0)
Immune surveillance: Smith, Richard T., and Landy, Maurice (Eds.). Academic Press, New York, 1971, 536 pp., $12.00 (1971) (0)

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