Hugo Oscar Besedovsky

Hugo Oscar Besedovsky's AcademicInfluence.com Rankings

Biology

#12653

World Rank

#16144

Historical Rank

Endocrinology

#192

World Rank

#205

Historical Rank

Immunology

#851

World Rank

#874

Historical Rank

Neuroscience

#2135

World Rank

#2195

Historical Rank

biology Degrees

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Biology

Hugo Oscar Besedovsky's Degrees

PhD Biomedical Sciences University of Buenos Aires
Doctorate Medicine University of Buenos Aires

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Hugo Oscar Besedovsky's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Immune-neuro-endocrine interactions: facts and hypotheses. (1996) (1486)
Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. (1986) (1478)
Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. (1987) (1122)
A neuromodulatory role of interleukin-1β in the hippocampus (1998) (461)
The immune response evokes changes in brain noradrenergic neurons. (1983) (430)
Immunoregulation mediated by the sympathetic nervous system, II. (1979) (383)
Immune-neuroendocrine interactions. (1985) (309)
Interleukin‐6: a cytokine to forget (2004) (287)
Cytokines as modulators of the hypothalamus-pituitary-adrenal axis (1991) (286)
Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease (2003) (250)
A neuromodulatory role of interleukin-1beta in the hippocampus. (1998) (224)
Lymphokine-containing supernatants from con A-stimulated cells increase corticosterone blood levels. (1981) (190)
Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice (1997) (189)
What do the immune system and the brain know about each other? (1983) (182)
Physiology of psychoneuroimmunology: A personal view (2007) (179)
Interleukin-1 induces changes in norepinephrine metabolism in the rat brain (1988) (174)
Neuroendocrine, sympathetic and metabolic responses induced by interleukin-1. (1989) (161)
Role of the thymus in programming of neuroendocrine functions. (1975) (159)
A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning (2013) (149)
The cytokine-HPA axis feed-back circuit (2000) (141)
Selective depletion of macrophages prevents pituitary-adrenal activation in response to subpyrogenic, but not to pyrogenic, doses of bacterial endotoxin in rats. (1991) (123)
Interleukin 1 affects glucose homeostasis. (1987) (121)
Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus (2011) (115)
Lymphoid cells produce an immunoregulatory glucocorticoid increasing factor (GIF) acting through the pituitary gland. (1985) (112)
Immunoregulation mediated by the sympathetic nervous system. (1979) (111)
Learning modulation by endogenous hippocampal IL‐1: Blockade of endogenous IL‐1 facilitates memory formation (2004) (101)
Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain (2006) (101)
Endocrine and cytokine responses in humans with pulmonary tuberculosis (2007) (100)
Thymus atrophy during Trypanosoma cruzi infection is caused by an immuno-endocrine imbalance (2007) (96)
Endogenous glucocorticoids cause thymus atrophy but are protective during acute Trypanosoma cruzi infection. (2006) (93)
Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases (2003) (92)
Central and Peripheral Cytokines Mediate Immune-Brain Connectivity (2010) (92)
Endogenous blood levels of corticosterone control the immunologic cell mass and B cell activity in mice. (1984) (91)
Neuroendocrine and metabolic responses induced by Interleukin‐1 (1987) (82)
Antidiabetic effects of interleukin 1. (1989) (80)
IL-1 resets glucose homeostasis at central levels (2006) (79)
Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide (2016) (76)
Interleukin‐1 and Glucocorticoid Hormones Integrate an Immunoregulatory Feedback Circuit a (1987) (73)
Disrupted brain-immune system-joint communication during experimental arthritis. (2008) (64)
Immune-neuroendocrine circuits: integrative role of cytokines. (1992) (63)
A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis (2011) (59)
Metabolic and neuroendocrine effects of pro-inflammatory cytokines. (1992) (58)
Physiological Implications of the Immune–Neuro–Endocrine Network (1991) (57)
Inhibition of Tumor Necrosis Factor-α Action within the CNS Markedly Reduces the Plasma Adrenocorticotropin Response to Peripheral Local Inflammation in Rats (1997) (54)
Cytokines mediate protective stimulation of glucocorticoid output during autoimmunity: involvement of IL-1. (1998) (52)
Altered Cortisol/DHEA Ratio in Tuberculosis Patients and its Relationship with Abnormalities in the Mycobacterial‐driven Cytokine Production by Peripheral Blood Mononuclear Cells (2007) (52)
Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson’s disease (2009) (52)
The Immuno‐endocrine Component in the Pathogenesis of Tuberculosis (2007) (51)
Chronic neuropathic pain–like behavior and brain‐borne IL‐1β (2012) (51)
Sympathetic immunoregulation: difference between high- and low-responder animals. (1982) (51)
Mechanism of virus-induced stimulation of the hypothalamus-pituitary-adrenal axis. (1989) (48)
Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury (2018) (48)
Introduction: immune-neuroendocrine network. (2002) (47)
Regulating inflammation by glucocorticoids (2006) (45)
Cortisol and Dehydroepiandrosterone Affect the Response of Peripheral Blood Mononuclear Cells to Mycobacterial Antigens during Tuberculosis (2004) (44)
Changes in plasma hormone profiles after tumor transplantation into syngeneic and allogeneic rats (1985) (44)
Administration of Interleukin‐1 at Birth Affects Dopaminergic Neurons in Adult Mice a (1998) (43)
Norepinephrine stimulates lymphoid cell mobilization from the perfused rat spleen via β-adrenergic receptors. (1999) (43)
Hippocampal Interleukin‐1β Gene Expression during Long‐Term Potentiation Decays with Age (2003) (42)
Alterations in the Pituitary–Adrenal Axis of Adult Mice Following Neonatal Exposure to Interleukin-1 (1996) (42)
Immune-Neuro-Endocrine Reflexes, Circuits, and Networks: Physiologic and Evolutionary Implications. (2017) (40)
The hypothalamus-pituitary-adrenal axis (2008) (40)
The cytokine-HPA axis circuit contributes to prevent or moderate autoimmune processes (2000) (39)
Involvement of noradrenergic nerves in the activation and clonal deletion of T cells stimulated by superantigen in vivo (2002) (37)
Central and Peripheral Mechanisms Contribute to the Hypoglycemia Induced by Interleukin‐1 a (1998) (36)
Endotoxin impedes vasoconstriction in the spleen: role of endogenous interleukin-1 and sympathetic innervation. (1997) (35)
Sympathetic Nervous System-Immune Interactions in Autoimmune Lymphoproliferative Diseases (2008) (35)
The bursa of Fabricius is required for normal endocrine development in chicken. (1980) (33)
Interleukin‐1, but Not Stress, Stimulates Glucocorticoid Output during Early Postnatal Life in Mice a (1998) (33)
T lymphocytes affect the development of sympathetic innervation of mouse spleen (1987) (33)
Behavioural endocrine immune-conditioned response is induced by taste and superantigen pairing (2004) (32)
Foundations of psychoneuroimmunology (1985) (31)
The Role of Noradrenergic Nerves in the Development of the Lymphoproliferative Disease in Fas-Deficient, lpr/lpr Mice1 (2006) (31)
Interleukin-1 increases splenic blood flow by affecting the sympathetic vasoconstrictor tonus. (1995) (30)
Interleukin-1 stimulates aldosterone secretion: involvement of renin, ACTH, and prostaglandins. (1992) (30)
Immunoendocrine Alterations during Human Tuberculosis as an Integrated View of Disease Pathology (2009) (29)
Immune–Neuroendocrine Network (1986) (29)
Intranasal delivery of dexamethasone efficiently controls LPS‐induced murine neuroinflammation (2017) (29)
Adverse neuro-immune–endocrine interactions in patients with active tuberculosis (2013) (27)
Taste-immunosuppression engram: Reinforcement and extinction (2007) (27)
Hsp72, inflammation, and aging: causes, consequences, and perspectives (2012) (24)
Feed-back interactions between immunological cells and the hypothalamus-pituitary-adrenal axis. (1991) (24)
Neuroendocrinology of interleukin-1. (1990) (23)
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment (2012) (23)
Re-exposure to endotoxin induces differential cytokine gene expression in the rat hypothalamus and spleen (2009) (23)
Interleukin-1 and glucose homeostasis: an example of the biological relevance of immune-neuroendocrine interactions. (1989) (23)
Increased Sensitivity of the Baroreceptor Reflex after Bacterial Endotoxin (2000) (22)
Immunoregulation by sympathetic nervous system (1981) (21)
When Immune-Neuro-Endocrine Interactions Are Disrupted: Experimentally Induced Arthritis as an Example (2010) (21)
Chemical destruction of brain noradrenergic neurons affects splenic cytokine production (2010) (21)
Impaired Immune Responses in Tuberculosis Patients Are Related to Weight Loss That Coexists with an Immunoendocrine Imbalance (2007) (21)
Interactions Between Endogenous Glucocorticoids and Inflammatory Responses in Normal and Tumor‐Bearing Mice: Role of T Cells (1988) (20)
The sympathetic nervous system affects the susceptibility and course of Trypanosoma cruzi infection (2016) (20)
Interleukin-1 Resets Glucose Homeostasis at Central and Peripheral Levels: Relevance for Immunoregulation (2010) (19)
Sympathetic abnormalities during autoimmune processes: potential relevance of noradrenaline-induced apoptosis. (2003) (18)
Helminth Infection Alters Mood and Short-Term Memory as well as Levels of Neurotransmitters and Cytokines in the Mouse Hippocampus (2014) (18)
The clinical recovery of tuberculosis patients undergoing specific treatment is associated with changes in the immune and neuroendocrine responses. (2017) (18)
Metabolic and Endocrine Actions of Interleukin‐1. (1990) (18)
Norepinephrine stimulates lymphoid cell mobilization from the perfused rat spleen via beta-adrenergic receptors. (1999) (17)
Murine taste-immune associative learning (2006) (17)
Hormonal changes following tumor transplantation: Factors increasing corticosterone and the relationship of corticosterone to tumor‐induced anti‐inflammation (1988) (17)
1 Brain Cytokines as Integrators of the Immune-Neuroendocrine Network (2008) (16)
A Clinical Correlate of the Dysregulated Immunoendocrine Response in Human Tuberculosis (2010) (14)
Local and systemic autonomic nervous effects on cell migration to the spleen. (2003) (14)
CHAPTER 10 – Emerging Concepts for the Pathogenesis of Chronic Disabling Inflammatory Diseases: Neuroendocrine-immune Interactions and Evolutionary Biology (2007) (13)
c-Fos Expression in the Rat Cerebral Cortex during Systemic GvH Reaction (2004) (13)
Interleukin‐1β and Insulin Elicit Different Neuroendocrine Responses to Hypoglycemia (2009) (13)
Not All Peripheral Immune Stimuli That Activate the HPA Axis Induce Proinflammatory Cytokine Gene Expression in the Hypothalamus (2000) (13)
TGF‐β neutralization abrogates the inhibited DHEA production mediated by factors released from M. tuberculosis–stimulated PBMC (2012) (13)
Intranasal Methylprednisolone Effectively Reduces Neuroinflammation in Mice With Experimental Autoimmune Encephalitis. (2019) (13)
Physiologic versus diabetogenic effects of interleukin-1: a question of weight. (2014) (12)
The Sympathetic Control of Blood Supply Is Different in the Spleen and Lymph Nodes (2003) (12)
Processing of Cytokine Signals at CNS Levels (2007) (12)
Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats. (2009) (12)
The Role of the Sympathetic Nervous System in the Thymus in Health and Disease (2011) (11)
Gender-associated differential expression of cytokines in specific areas of the brain during helminth infection. (2015) (11)
The immune system as a sensorial system that can modulate brain functions and reset homeostasis (2018) (11)
The Adrenal Steroid Response during Tuberculosis and Its Effects on the Mycobacterial‐driven IFN‐γ Production of Patients and Their Household Contacts (2009) (10)
Intranasal Dexamethasone Reduces Mortality and Brain Damage in a Mouse Experimental Ischemic Stroke Model (2020) (9)
Regulatory links between immune and neuroendocrine systems. (1989) (9)
Neuroendocrine Control of the Immune Response (1981) (8)
Failure of "thymus factor" to restore transplantation immunity in athymic mice. (1975) (8)
An adverse immune-endocrine profile in patients with tuberculosis and type 2 diabetes. (2016) (8)
Hormonal control of neutrophil chemotactic activity in the rat vagina. (1977) (8)
Endocrine host responses during early and late phases of tumor development (2000) (7)
Different peripheral neuroendocrine responses to Trypanosoma cruzi infection in mice lacking adaptive immunity (2012) (7)
Psychoneuroimmunology and cancer: fifteenth Sapporo Cancer Seminar. (1996) (6)
Foreword for Neuroimmunomodulation in Health and Disease (2012) (6)
The Immune-Endocrine-Metabolic Unit During Human Tuberculosis (2010) (6)
The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid. (2018) (6)
Central Blockade of IL-1 Does Not Impair Taste-LPS Associative Learning (2007) (6)
Effects of interleukin 1 on endocrine mechanisms (1987) (6)
Neuroendocrine Immunoregulatory Circuits (1983) (5)
The Role of Peripheral and Brain-Borne Cytokines in Immune-Neuro-Endocrine Interactions (2000) (5)
Network of bidirectional interactions between the neuroendocrine and immune systems. Preface. (2009) (4)
Foreword for Neuroimmunomodulation in Health and Disease (2012) (4)
Mimicking disruption of brain-immune system-joint communication results in collagen type II-induced arthritis in non-susceptible PVG rats (2015) (4)
Sympathetic Innervation Affects Superantigen‐Induced Decrease in CD4Vβ8 Cells in the Spleen (2000) (4)
Glucocorticoids and sympathetic neurotransmitters modulate the acute immune response to Trypanosoma cruzi (2019) (4)
On the Mechanism of Antiinflammation Induced by Tumor Transplantation, Surgery, and Irritant Injection (1991) (3)
A reduction in blood insulin levels as a host endocrine response during tumor development. (2000) (3)
Mouse fetal liver cells manifest antigen-specific suppressor activity. (1980) (3)
Delay in skin allograft rejection in rats grafted with fetal adrenal glands (1971) (3)
New Insights into Cytokine Gene Expression in the Rat Hypothalamus Following Endotoxin Challenge (2010) (3)
Mimicking disruption of the brain-immune system-joint communication results in expression of collagen type II arthritis in non-susceptible PVG rats (2011) (2)
[Influence of administration of glucocorticoids on the development of lymphoid organs in pregnant rats]. (1971) (2)
The Immune–Neuroendocrine Network in Health and Disease (2013) (2)
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients (2021) (2)
Host endocrine responses during tumor growth. (1989) (2)
[Why are there analogous disease mechanisms in chronic inflammatory diseases?]. (2007) (2)
Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice (2021) (2)
To protect or to kill: A persisting Darwinian immune dilemma (2022) (2)
The Role of Cytokines in Immune Neuroendocrine Interactions (1994) (2)
Treatment-Resistant Human Extraparenchymal Neurocysticercosis: An Immune-Inflammatory Approach to Cysticidal Treatment Outcome (2018) (1)
25. Disruption of the joint-immune-brain communication during experimental arthritis in the rat (2008) (1)
47. Regulatory T cells and the sympathetic nervous system in a murine model of autoimmune disease (2009) (1)
Brain cytokines integrate immune and neural signals (2004) (1)
Neuroimmunomodulation : from fundamental biology to therapy (2009) (1)
Effect of the combined treatment with 16 -methyl prednisone and radiation on the rat bone marrow. (1971) (1)
IL-1 receptor antagonist blocks the maintenance of long term potentiation in vitro and in vivo (1998) (1)
The Immune—Neuroendocrine Network (1999) (1)
Interactions between immunological cells and the hypothalamus pituitary-adrenal axis: an example of neuroendocrine immunoregulation. (1988) (1)
The Immune System as a Sensor Able to Affect Other Homeostatic Systems (2018) (1)
A multispecific internal (pRat6) for the analysis of rat cytokine mRNA levels by quantitative RT-PCR. (1996) (1)
Supression of fetal hematopoeitic development by prednisone treatment of pregnant rats (1974) (1)
Preface (2009) (0)
9.1 Immunological cells as a source of factors with neuroendocrine activity (1989) (0)
Subject Index Vol. 11, 2004 (2004) (0)
Regulatory Immune-Neuroendocrine Feedback Signals * (2019) (0)
Reviewer Acknowledgments (2009) (0)
The Immune-neuro-endocrine Network: the Interphase between Environmental and Internal Signals (2002) (0)
#103 Optimizing the behaviorally conditioned immunosuppression (2005) (0)
migration to the spleen Local and systemic autonomic nervous effects on cell (2015) (0)
The Journal of Rheumatology inflammatory cytokine effects. Cyclophosphamide adjuvant arthritis in Trypanosoma cruzi infected rats with (2003) (0)
The role of interleukin-1ß in hippocampal long-term potentiation (2000) (0)
Neuroendocrine and sympathetic responses to interleukin-1 in rats (1990) (0)
To protect or to kill: The immune system Darwinian's dilemma (2018) (0)
156. Immune-cell products from mice with an autoimmune disease affect apoptosis, proliferation and metabolism of PC12 cells, a model of sympathetic neurons (2013) (0)
Neural noradrenergic control of experimental Chagas’ disease (2013) (0)
10. Destruction of brainstem noradrenergic neurons affects splenic cytokine production (2009) (0)
Short communication Murine taste-immune associative learning (2006) (0)
Corrigendum for Ann. N. Y. Acad. Sci. 1153: 184–192 (2009) (0)
Cyclophosphamide adjuvant arthritis in Trypanosoma cruzi infected rats with inflammatory cytokine effects. (2003) (0)
Contents (2020) (0)
Acknowledgment of Reviewers (2003) (0)
Intranasal Dexamethasone Reduces Mortality and Brain Damage in a Mouse Experimental Ischemic Stroke Model (2020) (0)
A cytokine network in the brain during synaptic plasticity and learning (2013) (0)
The immune system tends to eliminate the host when it cannot control pathogenic threats: Evolutionary, medical, and epidemiologic perspectives (2023) (0)
Cytokines mediate protective stimulation of glucocorticoid output during autoimmunity: involvement of IL-1. (1998) (0)
Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide (2016) (0)
Contents Vol. 11, 2004 (2004) (0)
Immune-neuroendocrine interactions: Involvement of lymphokines and monokines (1991) (0)
Neuroendocrine Modulation of Immunity (1988) (0)
Disruption of the sympathetic innervation affects the susceptibility and course of a parasitic infection (2013) (0)

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Published Works

Hugo Oscar Besedovsky's AcademicInfluence.com Rankings