Huibert A. P. Pols

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Huibert A. P. Pols

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#4407

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#6905

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#1863

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#2720

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Philosophy

Huibert A. P. Pols's Degrees

PhD Medicine University of Amsterdam

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Huibert A. P. Pols's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Vitamin D (1928) (1836)
Body mass index as a predictor of fracture risk: A meta-analysis (2005) (1439)
Genetics and biology of vitamin D receptor polymorphisms. (2004) (1388)
Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study (2000) (1358)
Predictive Value of BMD for Hip and Other Fractures (2005) (1308)
A meta-analysis of previous fracture and subsequent fracture risk. (2004) (1162)
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women (2007) (1115)
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture (2012) (1045)
Smoking and fracture risk: a meta-analysis (2005) (878)
A Meta‐Analysis of Prior Corticosteroid Use and Fracture Risk (2004) (760)
Homocysteine levels and the risk of osteoporotic fracture. (2004) (719)
Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies (2009) (687)
Multinational, Placebo-Controlled, Randomized Trial of the Effects of Alendronate on Bone Density and Fracture Risk in Postmenopausal Women with Low Bone Mass: Results of the FOSIT Study (1999) (611)
Alcohol intake as a risk factor for fracture (2005) (599)
A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. (1998) (581)
Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. (2007) (577)
Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial. (2002) (543)
Bone mineral density in children and adolescents: relation to puberty, calcium intake, and physical activity. (1997) (533)
Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. (2002) (493)
Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study) (2004) (446)
Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: The Rotterdam Study (2006) (437)
A family history of fracture and fracture risk: a meta-analysis. (2004) (409)
An International Comparison of Serum 25-Hydroxyvitamin D Measurements (1999) (401)
Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. (2000) (394)
Polypharmacy and falls in the middle age and elderly population. (2006) (391)
A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. (2001) (385)
Bone Density in Non-Insulin-Dependent Diabetes Mellitus: The Rotterdam Study (1995) (357)
C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. (2006) (349)
Bone density and risk of hip fracture in men and women: cross sectional analysis (1997) (349)
A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. (2002) (338)
Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study. (2005) (336)
A New Approach to the Development of Assessment Guidelines for Osteoporosis (2002) (335)
The Rotterdam Study: objectives and design update (2007) (334)
Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. (2004) (324)
Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index (2003) (316)
Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells. (1997) (297)
The Incidence of Vertebral Fractures in Men and Women: The Rotterdam Study (2002) (297)
High Bone Mineral Density and Fracture Risk in Type 2 Diabetes as Skeletal Complications of Inadequate Glucose Control (2013) (296)
Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study (2000) (289)
Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture (2009) (267)
Endogenous hormones and carotid atherosclerosis in elderly men. (2003) (266)
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. (2008) (262)
The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis (2006) (254)
Thiazide Diuretics and the Risk for Hip Fracture (2003) (254)
A large‐scale population‐based study of the association of vitamin D receptor gene polymorphisms with bone mineral density (1996) (252)
A new marker for osteoarthritis: cross-sectional and longitudinal approach. (2004) (251)
Tea flavonoids may protect against atherosclerosis: the Rotterdam Study. (1999) (250)
Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size (2009) (247)
Mild hyponatremia as a risk factor for fractures: The rotterdam study (2011) (244)
Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance (1997) (238)
Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states (2004) (232)
Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight (2002) (229)
Prevalence and causes of visual field loss in the elderly and associations with impairment in daily functioning: the Rotterdam Study. (2001) (226)
Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials. (2004) (218)
Insulin and Cognitive Function in an Elderly Population: The Rotterdam Study (1997) (213)
Acetabular dysplasia predicts incident osteoarthritis of the hip: the Rotterdam study. (2005) (213)
An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits (2010) (213)
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. (2010) (210)
Risk of falls after withdrawal of fall-risk-increasing drugs: a prospective cohort study. (2007) (207)
A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. (1998) (206)
Estrogen Receptor α Gene Polymorphisms and Risk of Myocardial Infarction (2004) (204)
Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study (1996) (204)
Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. (2003) (203)
Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1,25‐dihydroxyvitamin D3 (2000) (188)
Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. (2001) (188)
Vitamin D control of osteoblast function and bone extracellular matrix mineralization. (2001) (187)
Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study (2006) (185)
Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study. (1996) (184)
Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study (2007) (182)
Risk Factors for Incident Vertebral Fractures in Men and Women: The Rotterdam Study (2004) (179)
Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis. (2007) (178)
Early identification of radiographic osteoarthritis of the hip using an active shape model to quantify changes in bone morphometric features: can hip shape tell us anything about the progression of osteoarthritis? (2007) (171)
Femoral Neck BMD Is a Strong Predictor of Hip Fracture Susceptibility in Elderly Men and Women Because It Detects Cortical Bone Instability: The Rotterdam Study (2007) (167)
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. (2005) (166)
Incidence and risk factors of disability in the elderly: the Rotterdam Study. (2007) (160)
The activin A‐follistatin system: potent regulator of human extracellular matrix mineralization (2007) (157)
Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a. (2006) (157)
A simple score for estimating the long-term risk of fracture in patients using oral glucocorticoids. (2005) (157)
Selective Serotonin Reuptake Inhibiting Antidepressants Are Associated With an Increased Risk of Nonvertebral Fractures (2008) (154)
Performance of risk indices for identifying low bone density in postmenopausal women. (2002) (150)
Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study. (2004) (148)
Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: the FAMOS study. (2005) (145)
Common Genetic Variation of the Low‐Density Lipoprotein Receptor‐Related Protein 5 and 6 Genes Determines Fracture Risk in Elderly White Men (2005) (145)
Loci at chromosomes 13, 19 and 20 influence age at natural menopause (2009) (143)
A meta-analysis of milk intake and fracture risk: low utility for case finding (2005) (143)
Non-compliance: the Achilles' heel of anti-fracture efficacy (2007) (142)
Interaction Between the Vitamin D Receptor Gene and Collagen Type Iα1 Gene in Susceptibility for Fracture (2001) (140)
Cdx‐2 Polymorphism in the Promoter Region of the Human Vitamin D Receptor Gene Determines Susceptibility to Fracture in the Elderly (2003) (140)
SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity (2009) (139)
Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. (2004) (138)
Influence of LRP5 Polymorphisms on Normal Variation in BMD (2004) (138)
Vitamin D Status, Bone Mineral Density, and the Development of Radiographic Osteoarthritis of the Knee: The Rotterdam Study (2009) (138)
Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms. (2006) (136)
A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly. (2000) (134)
Calculation of bioavailable and free testosterone in men: a comparison of 5 published algorithms. (2006) (128)
Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. (2003) (126)
Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. (2004) (124)
Effects of serum TSH and FT4 levels and the TSHR‐Asp727Glu polymorphism on bone: the Rotterdam Study (2007) (123)
Glucocorticoid receptor gene and risk of cardiovascular disease. (2008) (122)
Heritability of the Function and Structure of the Arterial Wall: Findings of the Erasmus Rucphen Family (ERF) Study (2005) (121)
Nutritional Intake of Vitamins K1 (Phylloquinone) and K2 (Menaquinone) in The Netherlands (1999) (120)
Osteoporosis in Men and Women: A Story About Bone Mineral Density Thresholds and Hip Fracture Risk (2002) (119)
Bone Mineral Density and the Risk of Peripheral Arterial Disease: The Rotterdam Study (2002) (119)
Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis. (2008) (118)
Sex-specific genetic effects influence variation in body composition (2008) (118)
Evidence for Involvement of 17β‐Estradiol in Intestinal Calcium Absorption Independent of 1,25‐Dihydroxyvitamin D3 Level in the Rat (1999) (113)
Somatostatin receptor scintigraphy: its value in tumor localization in patients with Cushing's syndrome caused by ectopic corticotropin or corticotropin-releasing hormone secretion. (1994) (113)
Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women. (2005) (113)
Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women. (2007) (112)
Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. The Rotterdam Study. (1997) (111)
Added value of bone mineral density in hip fracture risk scores. (1999) (110)
Collagen type I α1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women (2003) (109)
Vitamin D Binding Protein Genotype and Osteoporosis (2009) (109)
Glucocorticoid receptor polymorphism affects transrepression but not transactivation. (2006) (106)
Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT. (2006) (105)
Fractures in the elderly: epidemiology and demography. (2000) (102)
Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. (2004) (102)
Validity and reliability of three definitions of hip osteoarthritis: cross sectional and longitudinal approach (2004) (101)
Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes (2007) (101)
Inhibition of breast cancer cell growth by combined treatment with vitamin D3 analogues and tamoxifen. (1994) (98)
A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. (2003) (98)
Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. (1998) (97)
Prevalence and determinants of one month hand pain and hand related disability in the elderly (Rotterdam study) (2004) (97)
Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. (2010) (96)
The Prevalence of Low Bone Mineral Density in Dutch Perimenopausal Women: The Eindhoven Perimenopausal Osteoporosis Study (1998) (94)
Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men. (2005) (93)
The role of vitamin D receptor gene polymorphisms in bone biology (2002) (92)
Does hand osteoarthritis predict future hip or knee osteoarthritis? (2005) (92)
Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study. (2008) (92)
Endogenous oestrogens are related to cognition in healthy elderly women (2005) (92)
The importance of oestrogens in males (2003) (89)
The Role of Body Mass Index, Insulin, and Adiponectin in the Relation Between Fat Distribution and Bone Mineral Density (2009) (87)
A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. (2009) (87)
Estrogen Receptor α Gene Variation Is Associated With Risk of Myocardial Infarction in More Than Seven Thousand Men From Five Cohorts (2006) (87)
A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity. (2007) (86)
Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. (1997) (84)
Estrogen Receptor β (ESR2) Polymorphisms in Interaction With Estrogen Receptor α (ESR1) and Insulin‐Like Growth Factor I (IGF1) Variants Influence the Risk of Fracture in Postmenopausal Women (2006) (84)
Endogenous estradiol and risk of dementia in women and men: The Rotterdam Study (2003) (81)
Conformational change and enhanced stabilization of the vitamin D receptor by the 1,25-dihydroxyvitamin D3 analog KH1060. (1996) (81)
Arterial stiffness in postmenopausal women: determinants of pulse wave velocity (2002) (81)
Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study. (2005) (80)
Bone mineral density and mortality in elderly men and women: the Rotterdam Study. (2002) (80)
Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study. (2005) (80)
Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: the Rotterdam Study. (2003) (80)
Anti-tumor effects of 1,25-dihydroxyvitamin D3 and vitamin D analogs. (2000) (79)
The Influence of an Insulin‐Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study (2004) (78)
Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study. (2007) (78)
Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study (2008) (78)
Higher estrogen levels are not associated with larger hippocampi and better memory performance. (2003) (76)
Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. (1996) (76)
HMG‐CoA Reductase Inhibitors and the Risk of Vertebral Fracture (2004) (76)
Inappropriate benzodiazepine use in older adults and the risk of fracture. (2008) (75)
Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms (2004) (75)
Bone mineral density and the risk of breast cancer: the Rotterdam Study. (2003) (70)
Paget's Disease of Bone in The Netherlands: A Population‐Based Radiological and Biochemical Survey—The Rotterdam Study (2004) (69)
Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index (2010) (69)
Bone mineral density and bone metabolism of prepubertal children with asthma after long‐term treatment with inhaled corticosteroids (1997) (69)
Height in Pre- and Postmenopausal Women Is Influenced by Estrogen Receptor α Gene Polymorphisms (2004) (69)
Immunolocalization and quantification of noncollagenous bone matrix proteins in methylmethacrylate-embedded adult human bone in combination with histomorphometry. (1998) (67)
Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men. (2003) (64)
A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (2005) (64)
Distinct Effects on the Conformation of Estrogen Receptor α and β by Both the Antiestrogens ICI 164,384 and ICI 182,780 Leading to Opposite Effects on Receptor Stability (1999) (63)
Hormone replacement therapy and peripheral arterial disease: the Rotterdam study. (2000) (63)
A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7 q 22 (2010) (63)
Inhibition of insulin- and insulin-like growth factor-I-stimulated growth of human breast cancer cells by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogue EB1089. (1996) (62)
A Cross-Sectional Study on Biochemical Parameters of Bone Turnover and Vitamin D Metabolites in Healthy Dutch Children and Young Adults (2002) (62)
Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study. (2003) (62)
Gender differences in the associations between cortisol and insulin in healthy subjects. (1996) (61)
TGF-&bgr;1 Polymorphisms and Risk of Myocardial Infarction and Stroke: The Rotterdam Study (2006) (60)
A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism (2003) (59)
Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. (2006) (59)
Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone. (1992) (59)
COLIA1 polymorphism contributes to bone mineral density to assess prevalent wrist fractures. (2000) (58)
Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects. (2004) (58)
Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements. (1996) (58)
Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults (2004) (57)
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. (2005) (55)
A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients. (2006) (54)
Withdrawal of Fall‐Risk‐Increasing Drugs in Older Persons: Effect on Tilt‐Table Test Outcomes (2007) (54)
Vitamin D receptor gene haplotype is associated with body height and bone size. (2007) (54)
Assessment of fracture risk: who should be treated for osteoporosis? (2005) (54)
High Pretransplant Parathyroid Hormone Levels Increase the Risk for Graft Failure after Renal Transplantation (2006) (52)
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. (2009) (51)
Falls explain between-center differences in the incidence of limb fracture across Europe. (2002) (50)
Dietary electrolyte intake and blood pressure in older subjects: the Rotterdam Study (1996) (49)
Withdrawal of Fall-Risk-Increasing Drugs in Older Persons (2007) (49)
Renal transplantation and osteoporosis. (1995) (49)
Plasma Fibrinogen in NIDDM: The Rotterdam Study (1996) (49)
BMP‐2 Gene Polymorphisms and Osteoporosis: The Rotterdam Study (2006) (48)
Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms. (2004) (48)
Alterations in calcium metabolism in young people at risk for primary hypertension. The Dutch Hypertension and Offspring Study. (1993) (47)
24,25-Dihydroxyvitamin D3 and bone metabolism (2001) (47)
Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. (2003) (47)
Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women. (2006) (47)
Evidence that the self-induced metabolism of 1,25-dihydroxyvitamin D-3 limits the homologous up-regulation of its receptor in rat osteosarcoma cells. (1988) (47)
A Simple Risk Score for the Assessment of Absolute Fracture Risk in General Practice Based on Two Longitudinal Studies (2009) (46)
Low Dietary Riboflavin but Not Folate Predicts Increased Fracture Risk in Postmenopausal Women Homozygous for the MTHFR 677 T Allele (2007) (45)
Heritability of fasting glucose levels in a young genetically isolated population (2006) (44)
Noninvasive axial and peripheral assessment of bone mineral content: A comparison between osteoporotic women and normal subjects (1989) (44)
Heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor by parathyroid hormone (PTH) and PTH-like peptide in osteoblast-like cells. (1988) (43)
Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS (2017) (43)
Treatment of post‐menopausal osteoporosis with a combination of growth hormone and pamidronate: a placebo controlled trial (1995) (43)
Heritability of Serum Iron, Ferritin and Transferrin Saturation in a Genetically Isolated Population, the Erasmus Rucphen Family (ERF) Study (2006) (43)
Serum levels of sex hormone‐binding globulin (SHBG) are not associated with lower levels of non‐SHBG‐bound testosterone in male newborns and healthy adult men (2005) (42)
Vitamin D analogues: from molecule to clinical application (1994) (42)
Vitamin D Receptor Gene Polymorphism Predicts Height and Bone Size, Rather Than Bone Density in Children and Young Adults (2003) (42)
Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by parathyroid hormone and cAMP-agonists. (1992) (41)
Polymorphic variations in exon 10 of the luteinizing hormone receptor: Functional consequences and associations with breast cancer (2007) (41)
Smoking-dependent effects of the angiotensin-converting enzyme gene insertion/deletion polymorphism on blood pressure (2004) (40)
Differential effects of 1,25-dihydroxyvitamin D3-analogs on osteoblast-like cells and onin vitro bone resorption (1995) (40)
The -1997 G/T and Sp1 Polymorphisms in the Collagen Type I alpha1 (COLIA1) Gene in Relation to Changes in Femoral Neck Bone Mineral Density and the Risk of Fracture in the Elderly: The Rotterdam Study (2007) (39)
Bidirectional regulation of the 1,25-dihydroxyvitamin D3 receptor by phorbol ester-activated protein kinase-C in osteoblast-like cells: interaction with adenosine 3',5'-monophosphate-induced up-regulation of the 1,25-dihydroxyvitamin D3 receptor. (1992) (38)
Estrogen receptor alpha gene polymorphisms and bone mineral density in healthy children and young adults. (2004) (38)
Predictive value of BMD for hip and other fractures (Journal of Bone and Mineral Research (2005) 20, (1185-1194)) (2007) (37)
ApoE Gene Polymorphisms, BMD, and Fracture Risk in Elderly Men and Women: The Rotterdam Study (2004) (37)
Distinct effects on the conformation of estrogen receptor alpha and beta by both the antiestrogens ICI 164,384 and ICI 182,780 leading to opposite effects on receptor stability. (1999) (36)
Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention (2010) (36)
Bone density and body composition in chronic renal failure: effects of growth hormone treatment (2000) (36)
Genetics and Genomics of Osteoporosis (2001) (35)
Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia. (2007) (34)
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus (2013) (34)
Bone mineral density, bone metabolism and body composition of children with chronic renal failure, with and without growth hormone treatment (1998) (33)
Structure function analysis of vitamin D analogs with C-ring modifications. (1992) (32)
Single radionuclide scintigraphy with 99mtechnetium-sestamibi and ultrasonography in hyperparathyroidism. (1997) (32)
Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: The Erasmus Rucphen Family Study (2007) (32)
Tea and coronary heart disease: protection through estrogen-like activity? (2000) (32)
Cross-calibration of dual-energy X-ray densitometers for a large, multi-center genetic study of osteoporosis (2005) (31)
Prevalence and Causes of Visual Field Loss in the Elderly and Associations With Impairment in Daily Functioning (2001) (31)
The interleukin-6 –174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study (2008) (31)
A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women. (2005) (31)
Stretch‐induced modulation of matrix metalloproteinases in mineralizing osteoblasts via extracellular signal‐regulated kinase‐1/2 (2006) (30)
Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder. (2007) (30)
Serum Free and Total Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-1 and Insulin-Like Growth Factor Binding Protein-3Levels in Healthy Elderly Individuals (1998) (30)
2-Methoxyisobutylisonitrile Probe during Parathyroid Surgery: Tool or Gadget? (1998) (29)
How About Vitamin D Receptor Polymorphisms? (1998) (29)
Association of lumbar disc degeneration with osteoporotic fractures; the Rotterdam study and meta-analysis from systematic review. (2013) (29)
Intraoperative nuclear guidance in benign hyperparathyroidism and parathyroid cancer (1997) (28)
Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index. (2010) (28)
Estrogen receptors alpha and beta and the risk of open-angle glaucoma: the Rotterdam Study. (2008) (27)
Identifying genetic risk factors for osteoporosis. (2006) (27)
The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men. (2007) (27)
An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population. (2006) (26)
Evidence for coordinated regulation of osteoblast function by 1,25-dihydroxyvitamin D3 and parathyroid hormone. (1996) (25)
Antithrombin and atherosclerosis in the Rotterdam Study. (1996) (25)
The effect of 2 and 3 years of Raloxifene on vertebral and non-vertebral fractures in postmenopausal women with osteoporosis (1998) (24)
PTHR1 Polymorphisms Influence BMD Variation through Effects on the Growing Skeleton (2007) (24)
The effects of 1,25-dihydroxyvitamin D3 on growth, alkaline phosphatase and adenylate cyclase of rat osteoblast-like cells. (1986) (24)
An IGF-I Gene Polymorphism Modifies the Risk of Diabetic Retinopathy (2006) (24)
The influence of albumin on vitamin D metabolism in fetal chick osteoblast-like cells. (1984) (23)
The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9 (2007) (23)
Cost Effectiveness of Withdrawal of Fall-Risk-Increasing Drugs in Geriatric Outpatients (2008) (23)
A systematic evaluation of 151 candidate genes for their association with osteoporosis and osteoporotic fracture in a meta-analysis of genome-wide association data (2009) (22)
The role of hemochromatosis C282Y and H63D gene mutations in type 2 diabetes: findings from the Rotterdam Study and meta-analysis. (2002) (21)
Consequences of vitamin D receptor regulation for the 1,25-dihydroxyvitamin D3-induced 24-hydroxylase activity in osteoblast-like cells: initiation of the C24-oxidation pathway. (1997) (21)
Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition. (2014) (20)
Serum free and total insulin-like growth factor-I, insulin-like growth factor binding protein-1 and insulin-like growth factor binding protein-3 Levels in healthy elderly individuals. Relation to self-reported quality of health and disability. (1998) (20)
The T‐13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake (2010) (20)
IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes. (2006) (19)
High-dose testosterone is associated with atherosclerosis in postmenopausal women. (2007) (19)
Collagen Ia1 Polymorphism is Associated with Bone Characteristics in Caucasian Children and Young Adults (2002) (19)
A Simulation Model at Trabecular Level to Predict Effects of Antiresorptive Treatment after Menopause (2003) (19)
Transforming growth factor β-induced dissociation between vitamin D receptor level and 1,25-dihydroxyvitamin D3 action in osteoblast-like cells (1994) (19)
The effects of raloxifene on incident vertebral fractures in postmenopausal women with osteoporosis : 4-year results from the MORE trial (2000) (18)
Biochemical markers of bone turnover: an update. (1994) (18)
CHAPTER 68 – Genetic Vitamin D Receptor Polymorphisms and Risk of Disease (2005) (18)
Large-scale Meta-analysis of Genome-wide Association (GWA) Scans for Osteoporosis Traits: the GEFOS Consortium (2008) (18)
Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis. The Rotterdam Coronary Calcification Study. (2006) (18)
The RIZ Pro704 insertion-deletion polymorphism, bone mineral density and fracture risk: the Rotterdam study. (2008) (18)
Effects of the Renin-Angiotensin System Genes and Salt Sensitivity Genes on Blood Pressure and Atherosclerosis in the Total Population and Patients With Type 2 Diabetes (2007) (17)
A Central Dinucleotide within Vitamin D Response Elements Modulates DNA Binding and Transactivation by the Vitamin D Receptor in Cellular Response to Natural and Synthetic Ligands* (2002) (16)
Role of calcium and cAMP in heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor in an osteoblast cell line. (1990) (16)
[Locomotor disability in the elderly; the ERGO Study (Erasmus Rotterdam Health and the Elderly). ERGO Study Group]. (1995) (14)
The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes (2006) (14)
Bone mineral density in healthy Dutch women: spine and hip measurements using dual-energy X-ray absorptiometry. (1994) (14)
Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus. (2014) (14)
[CBO guideline 'Osteoporosis' (second revision]. (2002) (14)
Combined effects of 1,25-dihydroxyvitamin D3 and tamoxifen on the growth of MCF-7 and ZR-75-1 human breast cancer cells (2004) (13)
Effect of ketoconazole on metabolism and binding of 1,25-dihydroxyvitamin D-3 by intact rat osteogenic sarcoma cells. (1987) (13)
The increase in cholesterol with menopause is associated with the apolipoprotein E genotype. A population-based longitudinal study. (2004) (13)
Association of 5 0 estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk (2003) (13)
Contributions Serum Total IGF-I , Free IGF-I , and IGFBP-1 Levels in an Elderly Population Relation to Cardiovascular Risk Factors and Disease (2005) (13)
GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients (2007) (12)
Peripheral and axial bone mass in Dutch women. Relationship to age and menopausal state. (1988) (12)
Does bilirubin protect against hemochromatosis gene (HFE) related mortality? (2004) (11)
The effects of MC903 on 1,25-(OH)2D3 receptor binding, 24-hydroxylase activity and in vitro bone resorption. (1991) (11)
Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action. (2000) (11)
Modulation by epidermal growth factor of the basal 1,25(OH)2D3 receptor level and the heterologous up-regulation of the 1,25(OH)2D3 receptor in clonal osteoblast-like cells (2007) (10)
Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis (2010) (10)
Insulin, hypertension and antihypertensive drugs in elderly patients: the Rotterdam Study (1996) (10)
Twenty loci associated with bone mineral density identified by large-scale meta-analysis of genome-wide association datasets (2009) (8)
Practical Operationalizations of Risk Factors for Fracture in Older Women: Results From Two Longitudinal Studies (2009) (8)
Prior clinical vertebral fractures are a particularly strong predictor of hip fracture: A meta-analysis (2006) (7)
Vitamin D receptor gene polymorphisms and osteoporosis (1996) (7)
Antiestrogens inhibit in vitro bone resorption stimulated by 1,25-dihydroxyvitamin D3 and the vitamin D3 analogs EB1089 and KH1060. (1995) (7)
Effects of 1α-hydroxyvitamin D3 on various stages of predialysis renal bone disease (1989) (7)
Course and prognostic factors of disability in community‐dwelling older people with mild disability: The Rotterdam Study (2012) (7)
Tea Flavonoids May Protect Against Atherosclerosis (2015) (7)
Obesity and hip osteoarthritis. (2003) (7)
CHAPTER 89 – Vitamin D: Cancer and Differentiation (2005) (6)
Collagen Ialpha1 polymorphism is associated with bone characteristics in Caucasian children and young adults. (2002) (6)
370 A GENOME-WIDE ASSOCIATION STUDY IDENTIFIES A LOCUS ON CHROMOSOME 7Q22 TO INFLUENCE SUSCEPTIBILITY FOR OSTEOARTHRITIS (2009) (6)
The alpha-adducin gene is associated with macrovascular complications and mortality in patients with type 2 diabetes. (2006) (6)
Dietary assessment in the elderly: application of a two-step semi-quantitative food frequency questionnaire for epidemiological studies (1999) (6)
Subject Index Vol. 57, 2002 (2002) (5)
Early onset and sustained efficacy of raloxifene on incident vertebral fractures in postmenopausal women with ostoporosis : 4-year results from the MORE trial (2001) (5)
Detection of sequence variability of the collagen type IIα 1 3′ variable number of tandem repeat (2000) (5)
High body mass index, adjusted for BMD, is a risk factor for fracture in women (2012) (5)
Osmomediated natriuresis in humans: the role of vasopressin and tubular calcium sensing. (2009) (5)
Osteoporosis in the Netherlands; A burden of illness study commissioned by Merck Sharp & Dohme (1996) (4)
Cyclical etidronate in the prevention of corticosteroid-induced bane loss in primary biliary cirrhosis (1995) (4)
Role of extracellular calcium in the regulation of 1,25-dihydroxyvitamin D3 formation in cultured human keratinocytes. (1994) (4)
Effects of 1 alpha-hydroxyvitamin D3 on various stages of predialysis renal bone disease. (1989) (4)
Performance of self-assessment risk indices for encouraging appropriate use of bone density measurements among postmenopausal women. (2001) (4)
Insulin-like growth factor-I genotype and birthweight (2002) (4)
Population analysis of the collagen type IIα1 3′ variable number of tandem repeat polymorphism by heteroduplex genotyping (1998) (4)
Homocysteine, the vitamin B complex family and bone (2007) (3)
[Non-surgical treatment of primary hyperparathyroidism]. (1994) (3)
LOCI FOR REGULATION OF BMD IN MEN AND WOMEN THE FAMOS STUDY (2004) (3)
[A young woman with headaches and skull anomalies: a long road to the diagnosis 'Paget's disease']. (2006) (3)
Transforming growth factor beta-induced dissociation between vitamin D receptor level and 1,25-dihydroxyvitamin D3 action in osteoblast-like cells. (1994) (2)
A polymorphism in the gene for insulin-like growth factor-I: Functional properties and risk for type 2 diabetes mellitus and myocardial infarction (2000) (2)
How stressful can it be to catch a thief? The influence of stress on calcium metabolism. (2004) (2)
[Disorders of bone metabolism in gastrointestinal and hepatic diseases]. (2000) (2)
Vitamin D and Breast Cancer (1999) (2)
The cost-effectiveness of bone protection in patients using oral glucocorticoids. (2004) (2)
Effects of raloxifene on bone mineral density and biochemical markers of bone turnover in postmenopausal women with osteoporosis : 4-year results from the MORE trial (2000) (2)
[Preoperative noninvasive tests for localization of enlarged parathyroid glands in 115 patients with hyperparathyroidism]. (1994) (2)
GENETIC POLYMORPHISMS AND CLINICAL PRACTICE: THE EXAMPLE OF OSTEOPOROSIS (2002) (2)
Correction: Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study (2006) (2)
[Aging as a cause of hip fractures; a theoretic mathematical model]. (1996) (2)
Prednisone-induced hypercalcaemia in a patient with sarcoidosis and primary hyperparathyroidism. (1985) (1)
[Chronic idiopathic intestinal pseudo-obstruction]. (1983) (1)
385 IDENTIFICATION OF PRE-CLINICAL OSTEOARTHRITIS: A SUBCOHORT IN THE ROTTERDAM STUDY (2008) (1)
[Adrenal incidentaloma: a clinical problem related to imaging]. (2005) (1)
Regulation of calcium and bone metabolism (2008) (1)
Bidirectional Regulation of the 1,25=Dihydroxyvitamin Da Receptor by Phorbol Ester-Activated Protein Kinase- C in Osteoblast-Like Cells: Interaction with Adenosine (1992) (1)
Failure of H2-receptor antagonists to affect serum calcium and immunoreactive parathyroid hormone levels in normal subjects and patients with primary hyperparathyroidism. (1983) (1)
Estrogen Receptor α Polymorphisms and the Risk of Myocardial Infarction—Reply (2004) (1)
24,25-dihydroxyvitamin D, (24,25-) appears to favour cortical bone mass in renal bone disease (1992) (1)
[Endoscopic retroperitoneal adrenalectomy: a surgical improvement]. (1997) (1)
PP300-T/NIPP17 (recipient of a 2011 ECTS/IBMS Travel Award)Women with inadequately controlled type 2 diabetes are at increased risk of osteoporotic fractures despite higher bone mineral density: The Rotterdam study (2011) (1)
Growth factor-specific regulation of nuclear protein complex formation at vitamin D responsive elements (1995) (1)
Treatment of Predialysis Renal Bone Disease with 1 α -Hydroxy Derivatives of Vitamin D and Calcium Supplements (1992) (1)
ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION POLYMORPHISM AND RISK OF HEART FAILURE IN HYPERTENSIVE SUBJECTS: P2.215 (2004) (1)
Genetics & Genomics and Epigenetics 370 A GENOME-WIDE ASSOCIATION STUDY IDENTIFIES A LOCUS ON CHROMOSOME 7 Q 22 TO INFLUENCE SUSCEPTIBILITY FOR OSTEOARTHRITIS (2009) (1)
1 A FUNCTIONAL POLYMORPHISM IN THE CATECHOL-O METHYLTRANSFERASE (COMT) GENE IS ASSOCIATED WITH OA-RELATED PAIN (2007) (1)
ASBMR 26th Annual Meeting SU001–SU586 (2011) (0)
P1-201 Testosterone and risk of dementia in men and women: The Rotterdam Study (2006) (0)
Variations in bone density in Europe and the risk of spinal deformity (1995) (0)
THE INFLUENCE OF GENETIC AND ENVIRONMENTAL FACTORS ON BLOOD PRESSURE VARIANCE IN A GENETICALLY ISOLATED POPULATION: P2.224 (2004) (0)
CHAPTER 30 – Genetic Determinants of Osteoporosis (2008) (0)
Hormone Replacement Therapy and Peripheral Arterial Disease (2016) (0)
465 MODERATE TO SEVERE OSTEOARTHRITIS, BUT NO PAIN (2008) (0)
Genome-wide association study identifies klotho and other novel loci as contributors to BMD variation in postmenopausal women (2008) (0)
[Diagnosis of primary hyperparathyroidism]. (1987) (0)
Discerning the complex genetic architecture of human bone mineral density (BMD) variation using genome-wide association studies (GWAS) (2010) (0)
Ldl-Receptor Related Protein 5 Gene Polymorphisms Influence the Normal Variation of Bone Mineral Density (2004) (0)
In-silico sequencing of the GPR177 bone mineral density (BMD) locus using data from the “1000 genomes” project (2010) (0)
The genetic basis of cross-phenotype correlation with bone fracture risk: the GEFOS consortium (2013) (0)
Genetic Polymorphisms and Age-Related Diseases The Example of Osteoporosis (2004) (0)
2.P.281 Risk factors for aourtic atherosclerosis in elderly men and women (1997) (0)
92266403 Can nandrolone add to the effect of hormonal replacement therapy in postmenopausal osteoporosis (1993) (0)
[Fluoride in osteoporosis: not yet validated]. (1998) (0)
Contents Vol. 61, 2006 (2006) (0)
38. Hormone replacement therapy (HRT) and HRT combined with nandrolone in postmenopausal osteoporosis (PMO) (1991) (0)
A rare deletion event in 6p25 is associated with osteoporotic fractures in women (2009) (0)
082 SPINE OSTEOARTHRITIS DOES NOT PROTECT AGAINST INCIDENT VERTEBRAL FRACTURES DESPITE HIGHER LUMBAR SPINE BMD (2010) (0)
48. Uncoupling of bone formation and bone resorption in women with hip fractures. A prospective study (1997) (0)
Gender-specific associations of estrogen pathway genes with bone endpoints (2009) (0)
CHAPTER 28 – The Role of Genetic Variation in Osteoporosis (2006) (0)
Vitamin D action and regulation in bone cells (1988) (0)
Both increased and decreased biological activity of 26,27-hexafluoro-1,25(OH)2D3 compared to 1.25(OH)2D3 (1992) (0)
A simple chart for evaluating risk of osteoporosis based on the Osteoporosis Self-Assessment Tool (OST) (2002) (0)
CUMULATIVE RISKS OF FRACTURE IN PATIENTS USING ORAL GLUCOCORTICOIDS (2003) (0)
Functional characterization of GWAS loci associated with fracture risk (2013) (0)
[Renal osteodystrophy]. (1991) (0)
P6. Effects of TGFβ and EGF on 1,25-(OH)2D3 receptor level in osteoblast-like cells (UMR-106) (1990) (0)
[A patient with hypocalcemia: an experiment of nature and culture]. (1993) (0)
Renal osteodystrophy: an update on pathogenesis and treatment. (1989) (0)
THE EFFECT OF MC 903 AND 26,27 -HEXAFLUORO-1,25-(0H)2D3 ON VITAMIN D METABOLISM AND BONE RESORPTION (1991) (0)
REGULATION OF VITAMIN D ACTION IN RAT OSTEOGENIC SARCOMA CELLS (UMR-106). (1988) (0)
[Noninvasive measuring of bone mass and osteoporosis]. (1988) (0)
Genetic determinants and gene-environment interactions in relation to the 10-year longitudinal development of lumbar bone mineral density in (young) adults (2006) (0)
Bone Mineral Density in Non-Insulin-Dependent Diabetes Mellitus (1995) (0)
367 GENETIC VARIATION IN THE GDF5-UQCC REGION IS ASSOCIATED WITH HEIGHT, OSTEOARTHRITIS AND FRACTURE RISK: THE ROTTERDAM STUDY (2008) (0)
The Role of Genetic Variation in Osteoporosis (2006) (0)
469 C-REACTIVE PROTEIN LEVELS ARE ASSOCIATED WITH OA-RELATED KNEE PAIN IN WOMEN (2008) (0)
Inherited lipid disorders predisposing to type 2 diabetes mellitus (2005) (0)
Carcinoid tUIllOUTpTeSeafingasagiant hepatic cyst (1995) (0)
Corrigendum to “A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis” [Bone. 44S2 (2009) S224] (2010) (0)
FREQUENCY AND HERITABILITY OF THE METABOLIC SYNDROME IN A GENETICALLY ISOLATED POPULATION: 5A.2 (2004) (0)
Vitamin D: A modular of tumor cell proliferation and differentiation (1990) (0)
Absolute risk prediction for fracture (2007) (0)
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size SORANZO (2019) (0)
Prevalence and Causes of Visual Field Loss in the Elderly and Associations With Impairment in Daily FunctioningThe Rotterdam Study (2001) (0)
Estrogen Receptor Alpha Gene Polymorphisms Are Associated With Incident Late Ageing Macular Disease: The Rotterdam Study (2006) (0)
Contents Index Vol. 57, 2002 (2002) (0)
Conformational changeandenhancedstabilization ofthevitamin D receptor bythe1,25-dihydroxyvitamin (1996) (0)
P268 SUBCHONDRAL BONE PLATE REMODELING IN OSTEOARTHRITIS FOLLOWED OVER TIME BY IN VIVO MICRO-COMPUTED TOMOGRAPHY (2006) (0)
Subject Index Vol. 61, 2006 (2006) (0)
INTERACTION OF l,25(OH)2D3 AND TRANSFORMING GROWTH FACTOR IN HUMAN OSTEOSARCOMA CELLS (1991) (0)
Genome-wide association in the Rotterdam study implicates the 16q24 locus as determinant of osteoporotic vertebral fractures (2011) (0)
Varus Alignment Was Associated with an Increased Risk of Osteoarthritis of the Knee. Commentary (2007) (0)
LH receptor variance (2009) (0)

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