Hunter Fraser
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Biologist
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Hunter Fraserbiology Degrees
Biology
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Ecology
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Biology
Hunter Fraser's Degrees
- PhD Biology University of California, Berkeley
- Masters Biology University of California, Berkeley
- Bachelors Biology University of California, Berkeley
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Why Is Hunter Fraser Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hunter B. Fraser is a Professor of Biology at Stanford University and the chief PI of the Fraser lab at Stanford. He is also a member of Bio-X, Stanford's interdisciplinary biosciences institute, the Maternal & Child Health Research Institute , the Stanford Cancer Institute, and the Wu Tsai Neurosciences Institute. His research is in quantitative genomics, epigenetics, and evolutionary biology and has focused on developing new experimental and computational methods to study the evolution of gene expression in defining complex traits.
Hunter Fraser's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evolutionary Rate in the Protein Interaction Network (2002) (883)
- Noise Minimization in Eukaryotic Gene Expression (2004) (425)
- Factors underlying variable DNA methylation in a human community cohort (2012) (425)
- Protein dispensability and rate of evolution (2001) (416)
- N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility (2001) (343)
- Functional genomic analysis of the rates of protein evolution. (2005) (290)
- Detecting putative orthologs (2003) (290)
- Population-specificity of human DNA methylation (2012) (244)
- Ab initio construction of a eukaryotic transcriptome by massively parallel mRNA sequencing (2009) (237)
- Conservation and Evolution of Cis-Regulatory Systems in Ascomycete Fungi (2004) (236)
- Coevolution of gene expression among interacting proteins (2004) (234)
- Gene expression drives local adaptation in humans (2013) (221)
- Modularity and evolutionary constraint on proteins (2005) (185)
- A simple dependence between protein evolution rate and the number of protein-protein interactions (2003) (180)
- Aging and Gene Expression in the Primate Brain (2005) (173)
- Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse (2015) (165)
- Evidence for widespread adaptive evolution of gene expression in budding yeast (2010) (153)
- Accounting for biases in riboprofiling data indicates a major role for proline in stalling translation (2014) (135)
- Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints (2012) (127)
- Evolution at two levels of gene expression in yeast (2013) (122)
- Genetic variation in MHC proteins is associated with T cell receptor expression biases (2016) (120)
- Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing (2018) (119)
- Explaining mortality rate plateaus (2001) (112)
- Using protein complexes to predict phenotypic effects of gene mutation (2007) (105)
- Confirmation of Organized Modularity in the Yeast Interactome (2007) (102)
- Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum (2004) (99)
- Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos (2015) (98)
- Genome-wide approaches to the study of adaptive gene expression evolution: systematic studies of evolutionary adaptations involving gene expression will allow many fundamental questions in evolutionary biology to be addressed. (2011) (89)
- Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk (2016) (87)
- Common polymorphic transcript variation in human disease. (2009) (76)
- Adjusting for selection on synonymous sites in estimates of evolutionary distance. (2005) (74)
- Evolutionary rate depends on number of protein-protein interactions independently of gene expression level (2004) (70)
- Predictive Genes in Adjacent Normal Tissue Are Preferentially Altered by sCNV during Tumorigenesis in Liver Cancer and May Rate Limiting (2011) (66)
- The Quantitative Genetics of Phenotypic Robustness (2010) (65)
- Discordance of DNA Methylation Variance Between two Accessible Human Tissues (2015) (64)
- Systematic Detection of Polygenic cis-Regulatory Evolution (2011) (64)
- The somatic mutation landscape of the human body (2019) (63)
- Assessing the determinants of evolutionary rates in the presence of noise. (2007) (47)
- Transcript Length Mediates Developmental Timing of Gene Expression Across Drosophila (2013) (45)
- Codon Usage and Selection on Proteins (2006) (45)
- Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity (2012) (42)
- Fine-mapping cis-regulatory variants in diverse human populations (2018) (42)
- Worldwide patterns of human epigenetic variation (2015) (39)
- The Molecular Mechanism of a Cis-Regulatory Adaptation in Yeast (2013) (38)
- Behavior-dependent cis regulation reveals genes and pathways associated with bower building in cichlid fishes (2018) (37)
- Functional genetic variants revealed by massively parallel precise genome editing. Sharon et al (2018) (36)
- High-resolution mapping of cis-regulatory variation in budding yeast (2017) (33)
- Sum1p, the Origin Recognition Complex, and the Spreading of a Promoter-Specific Repressor in Saccharomyces cerevisiae (2005) (32)
- Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation (2010) (32)
- Tissue-Specific cis-Regulatory Divergence Implicates eloF in Inhibiting Interspecies Mating in Drosophila (2018) (31)
- Primate cell fusion disentangles gene regulatory divergence in neurodevelopment (2021) (31)
- Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation (2015) (31)
- Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution (2021) (30)
- Genomic function (communication arising): Rate of evolution and gene dispensability (2003) (30)
- A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers. (2013) (29)
- Ancient cis-regulatory constraints and the evolution of genome architecture. (2013) (28)
- A pooling-based approach to mapping genetic variants associated with DNA methylation (2015) (27)
- The cis-regulatory effects of modern human-specific variants (2020) (26)
- Improving Estimates of Compensatory cis-trans Regulatory Divergence. (2019) (25)
- Coevolution, modularity and human disease. (2006) (23)
- Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression (2012) (21)
- Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin (2016) (16)
- Spatially varying cis-regulatory divergence in Drosophila embryos elucidates cis-regulatory logic (2017) (15)
- Cell-cycle regulated transcription associates with DNA replication timing in yeast and human (2013) (14)
- Detecting selection with a genetic cross (2020) (13)
- Faculty Opinions recommendation of Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. (2009) (12)
- Comparative expression profiling reveals widespread coordinated evolution of gene expression across eukaryotes (2018) (12)
- Bacterial retrons enable precise gene editing in human cells (2021) (11)
- Estimating selection pressures from limited comparative data. (2006) (9)
- Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping (2020) (9)
- Disentangling Sources of Selection on Exonic Transcriptional Enhancers. (2016) (9)
- Population-specificity of human DNA methylation (2012) (9)
- Reply to Suderman et al.: Importance of accounting for blood cell composition in epigenetic studies (2013) (8)
- Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids (2016) (8)
- Evolutionary genomics: Codon volatility does not detect selection (reply) (2005) (6)
- Accounting for biases in riboprofiling data indicates a major role for proline and not positive amino acids in stalling translation (2014) (5)
- GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification (2021) (5)
- Lineage-specific selection and the evolution of virulence in the Candida clade (2021) (5)
- cis-Regulatory changes in locomotor genes are associated with the evolution of burrowing behavior. (2022) (4)
- Improving Estimates of Compensatory cis-trans Regulatory Divergence. (2019) (3)
- The somatic mutation landscape of the human body (2019) (3)
- Cis-regulatory changes in locomotor genes are associated with the evolution of burrowing behavior (2021) (3)
- Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits (2022) (3)
- Genetic control of age-related gene expression and complex traits in the human brain (2017) (2)
- Synonymous codon usage and selection on proteins (2004) (2)
- Tissue-specific cis-regulatory divergence implicates a fatty acid elongase necessary for inhibiting interspecies mating in Drosophila (2018) (2)
- Transcriptome diversity is a systematic source of variation in RNA-sequencing data (2022) (2)
- Disentangling sources of selection on exonic transcriptional enhancers (2015) (2)
- Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci (2020) (1)
- Existing methods are effective at measuring natural selection on gene expression (2022) (1)
- Phylogenetic expression profiling reveals widespread coordinated evolution of gene expression (2016) (1)
- Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing (2022) (1)
- Gene-by-environment interactions are pervasive among natural genetic variants (2022) (1)
- Divergent patterns of selection on metabolite levels and gene expression (2021) (1)
- Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping (2020) (1)
- Reply to Jensen and Rando: Population size change does not account for widespread gene expression adaptation in yeast (2010) (1)
- Chromatin activity identifies differential gene regulation across human ancestries (2022) (0)
- Evolution of Spatial and Temporal cis-Regulatory Divergence in Sticklebacks (2023) (0)
- Cell-cycle regulated transcription associates with DNA replication timing in yeast and human (2013) (0)
- Faculty Opinions recommendation of Genome-wide association analysis of clinical vs. nonclinical origin provides insights into Saccharomyces cerevisiae pathogenesis. (2011) (0)
- Allele-specific expression reveals genetic drivers of tissue regeneration in mice (2022) (0)
- Publisher Correction: Human–chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution (2021) (0)
- Genetic variation affecting temporal patterns of gene expression and disease in human brain (776.1) (2014) (0)
- Faculty Opinions recommendation of Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis. (2011) (0)
- Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids (2017) (0)
- Comparative expression profiling reveals widespread coordinated evolution of gene expression across eukaryotes (2018) (0)
- Faculty Opinions recommendation of System-wide molecular evidence for phenotypic buffering in Arabidopsis. (2009) (0)
- Common variants associated with mitotic-origin of aneuploidy in human embryos (2018) (0)
- Evolution of spatial and temporal cis-regulatory divergence between marine and freshwater sticklebacks (2022) (0)
- Faculty Opinions recommendation of Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. (2009) (0)
- Faculty Opinions recommendation of A tradeoff drives the evolution of reduced metal resistance in natural populations of yeast. (2011) (0)
- Faculty Opinions recommendation of The dynamics of adaptation on correlated fitness landscapes. (2010) (0)
- Faculty Opinions recommendation of A statistical framework for joint eQTL analysis in multiple tissues. (2013) (0)
- Phylogenetic expression profiling reveals widespread coordinated evolution of gene 1 ! expression 2 ! 3 ! (2016) (0)
- Faculty Opinions recommendation of Common regulatory variation impacts gene expression in a cell type-dependent manner. (2009) (0)
- Faculty Opinions recommendation of Patterns of cis regulatory variation in diverse human populations. (2012) (0)
- The cis -regulatory of modern human-specific variants. (2021) (0)
- Divergent patterns of selection on metabolite levels and gene expression (2021) (0)
- Reply to Zhang and Xu: Environment is indeed important in any phenotypic study (2021) (0)
- Elucidating Molecular Drivers of Wound Regeneration in MRL Mice Via Novel Transcriptomic Analyses (2020) (0)
- Faculty Opinions recommendation of The Future of Data Analysis in Evolutionary Genomics. (2014) (0)
- Faculty Opinions recommendation of Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. (2008) (0)
- Faculty Opinions recommendation of Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. (2009) (0)
- Abstract 98: Harnessing Novel Gene Expression Analyses To Identify Drivers Of Ear Regeneration In MRL Mice (2020) (0)
- Common polymorphic transcript variation in human disease Material (2009) (0)
- Transcriptome diversity is a systematic source of bias in RNA-sequencing data (2021) (0)
- Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression (2012) (0)
- Worldwide patterns of human epigenetic variation (2017) (0)
- Faculty Opinions recommendation of Global survey of genomic imprinting by transcriptome sequencing. (2009) (0)
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