H. Vasken Aposhian
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Toxicologist and emeritus professor of molecular and cell biology at the University of Arizona
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H. Vasken Aposhian's Degrees
- PhD Toxicology University of Utah
Why Is H. Vasken Aposhian Influential?
(Suggest an Edit or Addition)According to Wikipedia, Hurair Vasken Aposhian was a Ph.D. toxicologist and an emeritus professor of molecular and cell biology at the University of Arizona, a post he held beginning in 1975. He is also a former professor of pharmacology at the medical school at said university. He received his bachelor's degree in chemistry, at Brown University, 1948. He received a master's degree and a PhD in physiological chemistry at the University of Rochester, where he published some scientific studies about the synthesis of isoalloxazine ring-containing compounds. He did a postdoctoral with Nobel Laureate Arthur Kornberg in the department of biochemistry at Stanford University School of Medicine. He has done sabbatical scholar-in-residence at MIT and at the University of California at San Diego. He is best known for his pioneering work on Succimer and Unithiol in the treatment of arsenic, mercury, lead and other heavy metals leading to FDA approval of succimer in childhood lead poisoning at levels over 40 ug/dl. Previous posts he had held include at Vanderbilt, Tufts University, and the University of Maryland. His views about mercury in vaccines and in dental amalgams go against the consensus of the medical community and are controversial.
H. Vasken Aposhian's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem (2013) (956)
- Arsenic: health effects, mechanisms of actions, and research issues. (1999) (631)
- Enzymatic synthesis of deoxyribonucleic acid. IX. The polymerase formed after T2 bacteriophage infection of Escherichia coli: a new enzyme. (1962) (446)
- Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. (1997) (415)
- Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase. (2001) (338)
- ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. XIV. FURTHER PURIFICATION AND PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI. (1964) (330)
- Speciation of key arsenic metabolic intermediates in human urine. (2000) (317)
- DMSA and DMPS--water soluble antidotes for heavy metal poisoning. (1983) (311)
- Arsenic toxicology: five questions. (2006) (283)
- Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. (2000) (268)
- The enigma of arsenic carcinogenesis: role of metabolism. (1999) (260)
- Mobilization of heavy metals by newer, therapeutically useful chelating agents. (1995) (258)
- Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China. (2002) (242)
- A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. (2004) (219)
- Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. (2001) (214)
- meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. (1990) (188)
- Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine. (2000) (181)
- The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. (2003) (163)
- Variability in human metabolism of arsenic. (2003) (161)
- Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. (1996) (155)
- Structural basis of the antagonism between inorganic mercury and selenium in mammals. (2000) (154)
- Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. (1995) (153)
- Neurobehavioral effects from exposure to dental amalgam Hgo: new distinctions between recent exposure and Hg body burden (1998) (144)
- A Metabolic Link between Arsenite and Selenite: The Seleno-bis(S-glutathionyl) Arsinium Ion (2000) (139)
- DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III)), excreted in human urine. (2000) (131)
- Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. (2000) (131)
- Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. (1999) (129)
- Arsenate reductase II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. (2002) (115)
- Enzymatic methylation of arsenic compounds. V. Arsenite methyltransferase activity in tissues of mice. (1998) (114)
- Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles. (2003) (112)
- Human studies with the chelating agents, DMPS and DMSA. (1992) (105)
- Choroid plexus protects cerebrospinal fluid against toxic metals (1991) (101)
- Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes. (1999) (97)
- Oxidation and detoxification of trivalent arsenic species. (2003) (96)
- Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. (2000) (92)
- Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: enzyme and arsenic species concentrations in tissues after arsenate administration. (2006) (85)
- Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid. (1989) (80)
- Arsenic binding proteins of mammalian systems: I. Isolation of three arsenite-binding proteins of rabbit liver. (1994) (80)
- Behavioral effects of low-level exposure to Hg0 among dental professionals: a cross-study evaluation of psychomotor effects. (1998) (80)
- Urinary mercury after administration of 2,3‐dimercaptopropane‐1‐sulfonic acid: correlation with dental amalgam score (1992) (77)
- DMPS-arsenic challenge test. I: Increased urinary excretion of monomethylarsonic acid in humans given dimercaptopropane sulfonate. (1997) (74)
- Rabbit muscle creatine phosphokinase. CDNA cloning, primary structure and detection of human homologues. (1984) (72)
- Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig. (1997) (71)
- N-acetyl-DL-penicillamine, a new oral protective agent against the lethal effects of mercuric chloride. (1959) (71)
- DMSA, DMPS, and DMPA—as Arsenic Antidotes (1984) (69)
- Newer Developments in Arsenic Toxicity (1989) (67)
- Arsenite methylation by methylvitamin B12 and glutathione does not require an enzyme. (1999) (65)
- Central nervous system toxicity of manganese. II: Cocaine or reserpine inhibit manganese concentration in the rat brain. (1999) (61)
- Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine. (1989) (55)
- Urinary excretion of meso‐2,3‐dimercaptosuccinic acid in human subjects (1989) (52)
- Enzymatic methylation of arsenic compounds. VI. Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro. (1998) (48)
- Protection by D-penicillamine against the lethal effects of mercuric chloride. (1958) (47)
- DMSA, DMPS, and DMPA--as arsenic antidotes. (1984) (46)
- Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase. (2005) (45)
- DNA and gene therapy: transfer of mouse DNA to human and mouse embryonic cells by polyoma pseudovirions. (1971) (44)
- Anti-lewisite activity and stability of meso-dimercaptosuccinic acid and 2,3-dimercapto-1-propanesulfonic acid. (1982) (44)
- Dimercaptan metal-binding agents influence the biotransformation of arsenite in the rabbit. (1985) (43)
- Sodium 2,3-dimercapto-1-propanesulfonate (DMPS) treatment does not redistribute lead or mercury to the brain of rat. (1996) (42)
- Determination and metabolism of dithiol chelating agents. XII. Metabolism and pharmacokinetics of sodium 2,3-dimercaptopropane-1-sulfonate in humans. (1991) (41)
- BAL increases the arsenic-74 content of rabbit brain. (1983) (40)
- DNA and gene therapy: uncoating of polyoma pseudovirus in mouse embryo cells. (1970) (40)
- The Use of DNA for Gene Therapy—the Need, Experimental Approach, and Implications (2015) (40)
- Central Nervous System Toxicity of Manganese: I. Inhibition of Spontaneous Motor Activity in Rats after Intrathecal Administration of Manganese Chloride (1995) (39)
- Determination and metabolism of dithiol chelating agents: X. In humans, meso-2,3-dimercaptosuccinic acid is bound to plasma proteins via mixed disulfide formation. (1990) (39)
- DMPS (2,3-dimercaptopropane-1-sulfonate, dimaval) decreases the body burden of mercury in humans exposed to mercurous chloride. (1998) (38)
- Protection of mice against the lethal effects of sodium arsenite by 2,3 dimercapto-1-propane-sulfonic acid and dimercaptosuccinic acid. (1980) (37)
- Determination and metabolism of dithiol chelating agents. XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers. (1994) (37)
- Cell-free assembly of a polyoma-like particle from empty capsids and DNA. (1979) (35)
- Biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-dimercaptosuccinic acid. (1982) (34)
- Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS). (1998) (34)
- Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults. (1994) (34)
- DL- and meso-dimercaptosuccinic acid: in vitro and in vivo studies with sodium arsenite. (1983) (34)
- Diversity of inorganic arsenite biotransformation (1999) (31)
- Utilization of renal slices to evaluate the efficacy of chelating agents for removing mercury from the kidney. (1997) (31)
- Protection of mice against lethal effects of sodium arsenite--a quantitative comparison of a number of chelating agents. (1981) (30)
- The deoxycytidylate deaminase found in Bacillus subtilis infected with phage SP8. (1967) (29)
- Gene transfer by polyoma-like particles assembled in a cell-free system. (1983) (28)
- Central nervous system toxicity of manganese. I. Inhibition of spontaneous motor activity in rats after intrathecal administration of manganese chloride. (1995) (27)
- Fluorometric determination of 2,3-dimercaptopropane-1-sulfonic acid and other dithiols by precolumn derivatization with bromobimane and column liquid chromatography. (1986) (26)
- Binding of polonium-210 to liver metallothionein. (1991) (25)
- Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat. (1993) (24)
- Determination and metabolism of dithiol chelating agents. VII. Biliary excretion of dithiols and their interactions with cadmium and metallothionein. (1990) (24)
- Determination and metabolism of dithiol chelating agents. XVII. In humans, sodium 2,3-dimercapto-1-propanesulfonate is bound to plasma albumin via mixed disulfide formation and is found in the urine as cyclic polymeric disulfides. (1996) (24)
- PENICILLAMINE AND ANALOGOUS CHELATING AGENTS (1971) (22)
- How is Inorganic Arsenic Detoxified (1999) (22)
- Determination and metabolism of dithiol-chelating agents: electrolytic and chemical reduction of oxidized dithiols in urine. (1987) (22)
- Metabolism in vitro of the sulphydryl amino acids, L- and D-penicillamine. (1959) (21)
- Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. (2002) (20)
- Determination and metabolism of dithiol chelating agents. IV. Urinary excretion of meso-2,3-dimercaptosuccinic acid and mercaptosuccinic acid in rabbits given meso-2,3-dimercaptosuccinic acid. (1989) (19)
- GENE THERAPY SYSTEMS: THE NEED, EXPERIMENTAL APPROACH, AND IMPLICATIONS (1971) (19)
- A DTMPASE FOUND AFTER INFECTION OF BACILLUS SUBTILIS WITH PHAGE SP5C. (1965) (19)
- Polyoma-like particle: characterization of the DNA encapsidated in vitro by polyoma empty capsids. (1982) (19)
- Enzymatic methylation of arsenic compounds: II — an overview (1997) (18)
- Sodium 2,3-dimercaptopropane-1-sulfonate challenge test for mercury in humans. III. Urinary mercury after exposure to mercurous chloride. (1996) (17)
- Formation of nucleoprotein complexes between polyoma empty capsides and DNA (1975) (16)
- Synthesis and properties of the monomethyl ester of meso-dimercaptosuccinic acid and its chelates of lead (II), cadmium(II), and mercury(II). (1991) (16)
- Lead chelates of meso- and racemic-dimercaptosuccinic acid. (1989) (16)
- Polyoma Pseudovirions I. Sequence of Events in Primary Mouse Embryo Cells Leading to Pseudovirus Production (1972) (15)
- N-(2,3-dimercaptopropyl)phthalamidic acid: protection, in vivo and in vitro, against arsenic intoxication. (1984) (14)
- Tissue decorporation of polonium-210 in rats by DMPA. (1987) (14)
- Retardation of Growth of Walker Rat Carcinoma 256 by Administration of Diethyl Riboflavin.∗ (1951) (13)
- Determination and metabolism of dithiol chelating agents. III. Formation of oxidized metabolites of 2,3-dimercaptopropane-1-sulfonic acid in rabbit. (1988) (12)
- Deoxythymidylate 5'-nucleotidase. Purification and properties of an enzyme found after infection of Bacillus subtilis with phage SP5C. (1966) (12)
- The inhibition of Escherichia coli by 1-penicillamine and its reversal by isoleucine, valine or leucine. (1958) (11)
- N-(2,3-Dimercaptopropyl)phthalamidic acid (DMPA) increases polonium-210 excretion (2005) (10)
- A deoxyribonuclease found after infection of Bacillus subtilis with phage SP3. (1965) (10)
- Protein Expression in the Livers and Urinary Bladders of Hamsters Exposed to Sodium Arsenite (2008) (10)
- The biological activity of diethyl riboflavin. (1952) (10)
- The biological activity of 6-ethyl-9-(1'-D-ribityl)-isoalloxazine. (1960) (9)
- Polyoma pseudovirions: an experimental model for the development of DNA for gene therapy. (1972) (8)
- The reversal of the inhibitory activity of L-penicillamine by branched chain amino acids. (1959) (8)
- Optical isomers of 2,3-dimercapto-1-propanesulfonate: antidotal activity, in vitro and in vivo, against sodium arsenite. (1983) (7)
- The in vitro metabolism of 3α,17β-androstanediol by liver and kidney (1952) (7)
- The synthesis and breakdown of nucleic acids in mammalian cells transformed by oncogenic viruses. I. Purification and properties of an endonuclease from baby hamster kidney cells transformed by polyoma virus. (1970) (7)
- The in vivo synthesis of diethylriboflavin phosphate. (1955) (7)
- Transport and control of manganese ions in the central nervous system. (1999) (6)
- Polyoma Pseudovirions II. Influence of Host Cell on Pseudovirus Production (1973) (6)
- Studies on the Replication of DNA by Escherichia coli Polymerase (1963) (6)
- Biological Activity of 5-Hydroxymethyluracil and Its Deoxynucleoside in Noninfected and Phageinfected Bacillus subtilis (1969) (6)
- The inhibition of serine metabolism in Leuconostoc mesenteroides P-60. I. Microbiological activity of D- and L-penicillamine. (1957) (6)
- Experimental gene delivery systems for mammalian cells-the polyoma pseudovirus system. (1977) (5)
- Sequential cleavage of dinucleotides from DNA by phage Sp3 DNAse. (1968) (5)
- Pseudovirions in Animals, Plants, and Bacteria (1975) (5)
- Biochemical and pharmacological properties of the metal-binding agent penicillamine. (1961) (4)
- The dimethyl ester of meso-2,3-dimercaptosuccinic acid and its interactions with Cd2+ and rabbit liver metallothionein I. (1991) (4)
- Determination and metabolism of dithiol chelating agents: the zinc chelate of the dimethyl ester of meso-2,3-dimercaptosuccinic acid increase biliary excretion of cadmium and platinum. (1993) (4)
- Erratum to “Enzymatic methylation of arsenic compounds: IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig” [Mutation Res. 386 (1997) 229–239] (1997) (4)
- Sequential cleavage of dinucleotides from DNA by SP3 DNase. 3. Substrate specificity and initiation of the hydrolysis from the 5-terminus of polynucleotides. (1970) (4)
- Degradation of pseudoviral DNA after infection of mouse cells with polyoma pseudovirions. (1974) (4)
- Water soluble dithiol metal binding agents--efficacies and biotransformation. (2009) (3)
- [142] DNA polymerase from T2-infected Escherichia coli (1968) (3)
- The Synthesis of 6-Ethyl-9-(D-1'-ribityl)-isoalloxazine1 (1954) (2)
- Formation ofNucleoprotein Complexes Between Polyoma EmptyCapsids andDNA (1975) (2)
- Reversal of Inhibitory Activity of Chlorpromazine by Calcium.∗ (1959) (2)
- PENICILLAMINE AND DIMERCAPROL (1958) (2)
- The polyoma pseudovirion--its properties, production, and use in transferring DNA to mouse and human cells. (1973) (2)
- An efficient synthesis of sodium dimethylarsinate-14C (2003) (1)
- CORRECTIONS- The Deoxycytidylate Deaminase Found in Bacillus subtilis Infected with Phage SP8 (1968) (1)
- Enzymology and toxicity of inorganic arsenic (2003) (1)
- Neurotoxicity of metals: the new challenges. Introductory remarks (1995) (1)
- Assembly of a polyoma-like particle from empty capsids and DNA in a cell-free system. (1980) (1)
- The in vitro metabolism of 3 alpha, 17 beta-androstanediol by liver and kidney. (1952) (0)
- 1959 DMPS MODULATION OF ARSENIC SPECIES, INCLUDING MONOMETHYLARSONOUSACID (MMAlII), IN HUMAN URINE. (2000) (0)
- Cloning and Production of Human Acetylcholinesterase. (1983) (0)
- Discussion: Part I (1984) (0)
- Dithiol metal binding agents — Efficacies and properties in vivo and in vitro (1983) (0)
- Nature's death (1973) (0)
- Mammalian gene transfer - a poem (1974) (0)
- Discussion: Part I (1989) (0)
- Treatment of polonium poisoning with dimercapto chelating agents (1985) (0)
- DMPS (DIMAVAL) as a challenge test to assess the mercury and arsenic body/kidney load in humans and as a treatment of mercury toxicity (1996) (0)
- Prevention and Treatment of Vesication and Poisoning Caused by Arsenicals. (1981) (0)
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