Ingemar Björk
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(Suggest an Edit or Addition)Ingemar Björk's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. (1992) (475)
- Anticoagulant activity of heparin: Separation of high‐activity and low‐activity heparin species by affinity chromatography on immobilized antithrombin (1976) (355)
- Extension and structural variability of the antithrombin-binding sequence in heparin. (1984) (280)
- Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin. (1993) (255)
- Mechanism of the anticoagulant action of heparin (1982) (230)
- Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa. (1986) (221)
- Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects. (1991) (201)
- Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models. (1991) (200)
- Some Physicochemical Properties of Protein A from Staphylococcus aureus (1972) (194)
- Binding of high affinity heparin to antithrombin III. Stopped flow kinetic studies of the binding interaction. (1981) (186)
- The size and shape of human and bovine antithrombin III. (1977) (184)
- Heparin and Related Polysaccharides (1992) (156)
- Mechanism of Heparin Activation of Antithrombin (1998) (151)
- Studies on γ-crystallin from calf lens (1961) (132)
- Regulation of thrombin activity by antithrombin and heparin. (1994) (131)
- Accelerating ability of synthetic oligosaccharides on antithrombin inhibition of proteinases of the clotting and fibrinolytic systems Comparison with heparin and low-molecular-weight heparin (2004) (125)
- Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins. (1995) (116)
- Antithrombin. A bloody important serpin. (1997) (109)
- The Active Site Of Antithrombin. Release Of The Same Proteolytically Cleaved Form Of The Inhibitor From Complexes With Factor IXa, Factor Xa And Thrombin (1982) (109)
- Reinvestigation of some physicochemical and chemical properties of human ceruloplasmin (ferroxidase). (1976) (101)
- A Fragment of Histidine-Rich Glycoprotein Is a Potent Inhibitor of Tumor Vascularization (2004) (99)
- Binding of low-affinity and high-affinity heparin to antithrombin. Ultraviolet difference spectroscopy and circular dichroism studies. (1978) (95)
- The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change. (1997) (95)
- The binding of low-affinity and high-affinity heparin to antithrombin. Fluorescence studies. (1978) (94)
- Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor. (1992) (94)
- Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family (1995) (92)
- Structure and antithrombin-binding properties of heparin isolated from the clams Anomalocardia brasiliana and Tivela mactroides. (1987) (91)
- Evidence for similar conformational changes in alpha 2-macroglobulin on reaction with primary amines or proteolytic enzymes. (1982) (90)
- Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily (1995) (87)
- Mechanism of Acceleration of Antithrombin-Proteinase Reactions by Low Affinity Heparin (1995) (83)
- Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin. (1992) (82)
- Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes. (1994) (77)
- Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites. (2003) (74)
- Acceleration of the reaction between thrombin and antithrombin III by non-stoichiometric amounts of heparin. (1976) (74)
- Inactivation of Thrombin by Antithrombin Is Accompanied by Inactivation of Regulatory Exosite I* (1997) (72)
- Acidic pH as a physiological regulator of human cathepsin L activity. (2001) (71)
- Interaction of the cysteine proteinase inhibitor chicken cystatin with papain. (1988) (70)
- Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. (2000) (69)
- Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants. (2002) (69)
- Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites. (1998) (66)
- Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin. (1982) (64)
- Lysine 114 of Antithrombin Is of Crucial Importance for the Affinity and Kinetics of Heparin Pentasaccharide Binding* (2001) (63)
- The thrombin cleavage site in bovine antithrombin (1979) (63)
- Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region. (1984) (60)
- Decreased binding of heparin to antithrombin following the interaction between antithrombin and thrombin. (1977) (59)
- The importance of the second hairpin loop of cystatin C for proteinase binding. Characterization of the interaction of Trp-106 variants of the inhibitor with cysteine proteinases. (1996) (58)
- Two‐step mechanism of inhibition of cathepsin B by cystatin C due to displacement of the proteinase occluding loop (1998) (56)
- Binding of heparin to human high molecular weight kininogen. (1989) (56)
- Recovery of native conformation of rabbit immunoglobulin G upon recombination of separately renatured heavy and light chains at near-neutral pH. (1971) (56)
- The site in human antithrombin for functional proteolytic cleavage by human thrombin (1981) (55)
- Functional domains of rabbit thrombomodulin. (1986) (55)
- Role of Arginine 129 in Heparin Binding and Activation of Antithrombin* (2000) (55)
- Kinetics of binding of chicken cystatin to papain. (1989) (54)
- Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A beta-sheet of the inhibitor during trapping of target proteinases. (1993) (54)
- Effect of individual carbohydrate chains of recombinant antithrombin on heparin affinity and on the generation of glycoforms differing in heparin affinity. (1997) (53)
- Release of a two-chain form of antithrombin from the antithrombin-thrombin complex. (1979) (53)
- Regulation of Thrombin by Antithrombin and Heparin Cofactor II (1992) (53)
- Decreased affinity of recombinant antithrombin for heparin due to increased glycosylation. (1992) (48)
- Gross conformation of free polypeptide chains from rabbit immunoglobulin G. I. Heavy chain. (1971) (48)
- Importance of lysine 125 for heparin binding and activation of antithrombin. (2002) (48)
- The production of an inactive form of antithrombin through limited proteolysis by thrombin (1979) (48)
- Influence of ionic strength and pH on the interaction between high-affinity heparin and antithrombin. (1981) (47)
- Subunit Structure of Helix pomatia A Hemagglutinin (1972) (47)
- Interaction between chicken cystatin and the cysteine proteinases actinidin, chymopapain A, and ficin. (1990) (47)
- The role of Arg46 and Arg47 of antithrombin in heparin binding. (1999) (45)
- A Novel Anti-angiogenic Form of Antithrombin with Retained Proteinase Binding Ability and Heparin Affinity* (2001) (45)
- Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor. (1992) (44)
- Protein structural requirements for Ca2+ binding to the light chain of factor X. Studies using isolated intact fragments containing the gamma-carboxyglutamic acid region and/or the epidermal growth factor-like domains. (1991) (44)
- Cystatin inhibition of cathepsin B requires dislocation of the proteinase occluding loop. Demonstration by release of loop anchoring through mutation of His110 (2000) (43)
- Characterization by rapid-kinetic and equilibrium methods of the interaction between N-terminally truncated forms of chicken cystatin and the cysteine proteinases papain and actinidin. (1992) (42)
- Probing the functional role of the N-terminal region of cystatins by equilibrium and kinetic studies of the binding of Gly-11 variants of recombinant human cystatin C to target proteinases. (1995) (42)
- Chromatographic separation of bovine α-crystallin* (1963) (42)
- Structural requirements for Ca2+ binding to the gamma-carboxyglutamic acid and epidermal growth factor-like regions of factor IX. Studies using intact domains isolated from controlled proteolytic digests of bovine factor IX. (1991) (41)
- The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139. (2000) (40)
- Specificity of the basic side chains of Lys114, Lys125, and Arg129 of antithrombin in heparin binding. (2002) (39)
- Studies on the binding of heparin to prothrombin and thrombin and the effect of heparin-binding on thrombin activity. (1978) (39)
- Elimination of glycosylation heterogeneity affecting heparin affinity of recombinant human antithrombin III by expression of a beta-like variant in baculovirus-infected insect cells. (1995) (38)
- Binding to antithrombin of heparin fractions with different molecular weights. (1981) (37)
- Role of protein conformational changes, surface approximation and protein cofactors in heparin-accelerated antithrombin-proteinase reactions. (1992) (37)
- Binding of secretory component to dimers of immunoglobulin A in vitro. Mechanism of the covalent bond formation. (1976) (36)
- High‐molecular‐weight kininogen binds two molecules of cysteine proteinases with different rate constants (1996) (36)
- Purification of thrombin by affinity chromatography on immobilized heparin. (1977) (36)
- The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L. (1998) (36)
- Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinases (1995) (36)
- Denaturation behavior of antithrombin in guanidinium chloride. Irreversibility of unfolding caused by aggregation. (1985) (35)
- Characterization by spectroscopic, kinetic and equilibrium methods of the interaction between recombinant human cystatin A (stefin A) and cysteine proteinases. (1995) (35)
- Calcium affinity of the NH2-terminal epidermal growth factor-like module of factor X. Effect of the gamma-carboxyglutamic acid-containing module. (1993) (34)
- Studies on γ-crystallin from calf lens: III. Comparison of the main protein components by peptide mapping* (1970) (34)
- A conformational study of normal and dicoumarol‐induced prothrombin (1973) (33)
- Gross conformation of human secretory immunoglobulin A and its component parts. (1974) (33)
- High‐affinity binding of two molecules of cysteine proteinases to low‐molecular‐weight kininogen (1995) (31)
- Structural and functional properties of heparin analogues obtained by chemical sulphation of Escherichia coli K5 capsular polysaccharide. (1995) (31)
- Proteolytic formation and properties of a fragment of protein C containing the gamma-carboxyglutamic acid rich domain and the EGF-like region. (1990) (30)
- Kinetics of appearance of sulfhydryl groups in alpha 2-macroglobulin on reaction of the inhibitor with amines. (1984) (30)
- Fractionation of β-crystallin from calf lens by gel filtration† (1964) (28)
- Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the inhibition of cysteine proteinases (2001) (28)
- Evidence by chemical modification for the involvement of one or more tryptophanyl residues of bovine antithrombin in the binding of high-affinity heparin. (1979) (28)
- Changes of the proteinase binding properties and conformation of bovine alpha 2-macroglobulin on cleavage of the thio ester bonds by methylamine. (1985) (28)
- Slow, spontaneous dissociation of the antithrombin—thrombin complex produces a proteolytically modified form of the inhibitor (1980) (28)
- Importance of the second binding loop and the C-terminal end of cystatin B (stefin B) for inhibition of cysteine proteinases. (1999) (28)
- Effects of gamma-carboxyglutamic acid and epidermal growth factor-like modules of factor IX on factor X activation. Studies using proteolytic fragments of bovine factor IX. (1992) (28)
- Mechanism of inactivation of trypsin by antithrombin. (1982) (28)
- Interaction of chicken cystatin with inactivated papains. (1989) (28)
- Isoelectric Focusing of alpha-Crystallin Subunits. (1968) (27)
- Properties of antithrombin-thrombin complex formed in the presence and in the absence of heparin. (1983) (27)
- Conformational studies of the human vitamin A-transporting protein complex. (1972) (26)
- Grafting of features of cystatins C or B into the N-terminal region or second binding loop of cystatin A (stefin A) substantially enhances inhibition of cysteine proteinases. (2003) (26)
- Papain labelled with fluorescent thiol-specific reagents as a probe for characterization of interactions between cysteine proteinases and their protein inhibitors by competitive titrations. (1991) (26)
- Independent folding of the variable and constant halves of a lambda immunoglobulin light chain. (1971) (26)
- Structural comparison of the precursor and the mature form of napin, the 2S storage protein in Brassica napus. (1996) (25)
- Routes of thrombin action in the production of proteolytically modified, secondary forms of antithrombin-thrombin complex. (1979) (25)
- Isolation and phagocytic properties of neutrophils and other phagocytes from nonmastitic bovine milk. (1991) (25)
- The conformational changes of alpha 2-macroglobulin induced by methylamine or trypsin. Characterization by extrinsic and intrinsic spectroscopic probes. (1987) (25)
- The contribution of N-terminal region residues of cystatin A (stefin A) to the affinity and kinetics of inhibition of papain, cathepsin B, and cathepsin L. (1999) (24)
- The binding of low-affinity and high-affinity heparin to antithrombin. Competition for the same binding site on the protein. (1978) (24)
- Purification and characterization of an inhibitor of plasminogen activation from post-traumatic patients (1976) (24)
- Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change. (2004) (23)
- The stability of deoxyribonucleic acid in glycol solution (1963) (23)
- Association-dissociation behaviour and hydrodynamic properties of apoferritin monomer and dimer. (1973) (22)
- Stoichiometry of reactions of alpha 2-macroglobulin with trypsin and chymotrypsin. (1984) (21)
- Some physiochemical properties of protein A from Staphylococcus aureus. (1972) (21)
- Comparative studies of α-crystallin from lenses of different mammalian species (1968) (21)
- Different roles of the two disulfide bonds of the cysteine proteinase inhibitor, chicken cystatin, for the conformation of the active protein. (1992) (20)
- Evidence by chemical modification that tryptophan-104 of the cysteine-proteinase inhibitor chicken cystatin is located in or near the proteinase-binding site. (1990) (20)
- Kinetic Characterization of the Proteinase Binding Defect in a Reactive Site Variant of the Serpin, Antithrombin (1995) (19)
- The affinity and kinetics of inhibition of cysteine proteinases by intact recombinant bovine cystatin C. (1999) (19)
- Mechanism of action of heparin and heparin-like antithrombotics (1994) (18)
- Purification of a Fibrinolysis Inhibitor in Serum from Post-Traumatic Patients (1978) (18)
- Binding of secretory component to human immunoglobulin M. (1976) (18)
- A pre-steady-state kinetic analysis of substrate binding to human recombinant deoxycytidine kinase: a model for nucleoside kinase action. (1999) (18)
- Contributions of individual residues in the N-terminal region of cystatin B (stefin B) to inhibition of cysteine proteinases. (2003) (17)
- A rapid technique for the isolation of highly purified, functionally intact bovine neutrophilic granulocytes. (1988) (17)
- Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases. (1998) (17)
- Reaction of proteinases with alpha 2-macroglobulin: rapid-kinetic evidence for a conformational rearrangement of the initial alpha 2-macroglobulin-trypsin complex. (1991) (16)
- Subunits of human alpha 2-macroglobulin produced by specific reduction of interchain disulfide bonds with thioredoxin. (1988) (16)
- Permanent activation of antithrombin by covalent attachment of heparin oligosaccharides (1982) (16)
- The epidermal growth factor precursor. A calcium-binding, beta-hydroxyasparagine containing modular protein present on the surface of platelets. (1999) (16)
- Non-productive activation of the proteinase binding sites of alpha 2-macroglobulin on reaction of the inhibitor with matrix-linked trypsin. (1984) (16)
- Separation of calf-lens proteins by means of vertical-column zone electrophoresis☆ (1960) (16)
- Binding of secretory component to dimers of immunoglobulin A in vitro. A model for the interactions of the two moieties in secretory immunoglobulin A. (1974) (16)
- Binding of proteinases to human alpha 2-macroglobulin with its thioester bonds cleaved by methylamine in the presence of a thiol-group-cyanylating reagent. (1985) (16)
- A periodate-sensitive anti-phagocytic surface structure, induced by growth in milk whey, on Staphylococcus aureus isolated from bovine mastitis. (1991) (15)
- Properties of the Fd fragment from rabbit immunoglobulin G. (1972) (14)
- A differential effect of low-affinity heparin on the inhibition of thrombin and factor Xa by antithrombin. (1980) (12)
- Kinetics of Heparin Action a (1989) (12)
- The N‐terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two‐step binding by rapid‐kinetic studies of cystatin A labeled at the N‐terminus with a fluorescent reporter group (2000) (11)
- Recovery of the native conformations of the variable and constant halves of an immunoglobulin light chain upon renaturation from the linear random coil state. (1972) (11)
- Immunological evidence for a proteolytic cleavage at the active site of antithrombin in the mechanism of inhibition of coagulation serine proteases. (1981) (11)
- Interaction of cysteine proteinases with recombinant kininogen domain 2, expressed in Escherichia coli (1995) (11)
- Calcium binding to the first EGF‐like module of human factor IX in a recombinant fragment containing residues 1–85 (1998) (10)
- Properties of the complex between alpha 2-macroglobulin and brinase, a proteinase from Aspergillus oryzae with thrombolytic effect. (1988) (10)
- Conformational changes in human fibrinogen after in vitro phosphorylation and their relation to fibrinogen behaviour (1990) (10)
- The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73. (2002) (9)
- Molecular cloning and N-terminal analysis of bovine cystatin C. Identification of a full-length N-terminal region. (1997) (9)
- The high stability of cruzipain against pH‐induced inactivation is not dependent on its C‐terminal domain (2000) (9)
- Fractionation of heparin by chromatography on immobilized thrombin. Correlation between the anticoagulant activity of the fractions and their content of heparin with high affinity for antithrombin. (1980) (9)
- Epidermal Growth Factor‐like Domains in the Vitamin K‐Dependent Clotting Factors (1991) (8)
- Relative rates of the non-covalent and covalent binding of secretory component to an IgA dimer. (2009) (8)
- Apparent Formation of Sodium Dodecyl Sulfate-stable Complexes between Serpins and 3,4-Dichloroisocoumarin-inactivated Proteinases Is Due to Regeneration of Active Proteinase from the Inactivated Enzyme* (1997) (7)
- Wild-type and met-65-->Leu variants of human cystatin A are functionally and structurally identical. (2000) (7)
- A novel strategy to generate biologically active neo-glycosaminoglycan conjugates. (1999) (7)
- Hydrophobic sequences can substitute for the wild-type N-terminal sequence of cystatin A (stefin A) in tight binding to cysteine proteinases selection of high-affinity N-terminal region variants by phage display. (1999) (7)
- A new technique, requiring small amounts of cells, for the parallel study of chemiluminescence and phagocytosis via different receptors in the same cell population. (1991) (6)
- Biphasic transition curve on denaturation of chicken cystatin by guanidinium chloride Evidence for an independently unfolding structural region (1992) (6)
- Identification of an epitope in antithrombin appearing on insertion of the reactive-bond loop into the A beta-sheet. (1996) (5)
- Exposure to solvent of tyrosyl and tryptophanyl residues of bovine antithrombin in the absence and presence of high-affinity and low-affinity heparin. (1980) (5)
- The structure around the thioester bond in bovine alpha 2-macroglobulin. Possible implications for the conformational stability of the inhibitor on thioester cleavage. (1986) (5)
- Structural requirements for the interaction of heparin with antithrombin III. (1977) (4)
- Production by Thrombin of a Proteolytically Modified form of Antithrombin and Release of the Same form from the Antithrombin-Thrombin Complex (1979) (4)
- Tissue distribution of bovine cystatin C analysed by in situ hybridisation. (2000) (3)
- Equilibrium and kinetic studies of the interaction of chicken cystatin with four cysteine proteinases. (1990) (3)
- Studies on the soluble proteins of the bovine lens : purification and characterization (1964) (2)
- Gross conformation of free polypeptide chains from rabbit immunoglobulin G. II. Light chain. (1971) (1)
- Purification and characterization of a plasminogen activation inhibitor (1976) (1)
- Characterization of urokinase inhibitors (1975) (1)
- BINDING OF HEPARIN TO H-KININOGEN (1987) (0)
- Binding of Dextran Sulphate to Antithrombin (1979) (0)
- S5.9 Heparin-like compounds prepared by chemical modification of capsular polysaccharide from E. coli K5 (1993) (0)
- Mechanism Of The Inactivation Of Trypsin By Antithrombin III (1981) (0)
- The finding that secretory component is not associated with gamma-glutamyltranspeptidase activity. (1977) (0)
- Antithrombin - Mechanism Of Action And Binding Of Heparin (1981) (0)
- THE FINDING THAT SECRETORY COMPONENT IS NOT ASSOCIATED WITH γ‐GLUTAMYLTRANSPEPTIDASE ACTIVITY (2009) (0)
- On the Reliability of the Use of Heparin Immobilized on Agarose for the Study of the Interactions among Heparin, Thrombin and Antithrombin (1982) (0)
- The structure around the thioester bond in bovine α2‐macroglobulin (2001) (0)
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What Schools Are Affiliated With Ingemar Björk?
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