Ian Chopra
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Ian Choprabiology Degrees
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Molecular Biology
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Medical Biology
Why Is Ian Chopra Influential?
(Suggest an Edit or Addition)Ian Chopra's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance (2001) (3511)
- The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern? (2007) (704)
- Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections (2010) (636)
- Tetracyclines, molecular and clinical aspects. (1992) (378)
- Organic acids: chemistry, antibacterial activity and practical applications. (1991) (371)
- The role of mutators in the emergence of antibiotic-resistant bacteria. (2003) (237)
- Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement. (2008) (237)
- Staphylococcus aureus Biofilms Promote Horizontal Transfer of Antibiotic Resistance (2013) (233)
- Short-chain organic acids at ph 5.0 kill Escherichia coli and Salmonella spp. without causing membrane perturbation. (1991) (231)
- Increased mutability of Pseudomonas aeruginosa in biofilms. (2008) (216)
- Understanding antibacterial action and resistance (1990) (195)
- The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics (1997) (194)
- Effect of short-chain organic acids on macromolecular synthesis in Escherichia coli. (1990) (177)
- Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents (2005) (177)
- New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors. (2002) (138)
- Structure-based discovery of antibacterial drugs (2010) (138)
- Joint Tolerance to β-Lactam and Fluoroquinolone Antibiotics in Escherichia coli Results from Overexpression of hipA (1998) (130)
- Glycylcyclines: third-generation tetracycline antibiotics. (2001) (124)
- Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus. (2001) (123)
- Exploiting current understanding of antibiotic action for discovery of new drugs (2002) (123)
- Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus. (2008) (122)
- Plasmid-mediated tetracycline resistance in Escherichia coli involves increased efflux of the antibiotic. (1980) (120)
- Genetic Basis of Resistance to Fusidic Acid in Staphylococci (2007) (116)
- In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis. (2005) (115)
- Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence (2006) (111)
- Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques (2004) (107)
- The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens (2012) (107)
- Molecular basis of beta-lactamase induction in bacteria (1993) (106)
- The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies. (2013) (106)
- Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin (2001) (104)
- Characterization of the Epidemic European Fusidic Acid-Resistant Impetigo Clone of Staphylococcus aureus (2007) (100)
- Leakage of periplasmic proteins from Escherichia coli mediated by polymyxin B nonapeptide (1986) (99)
- Molecular basis of fusB‐mediated resistance to fusidic acid in Staphylococcus aureus (2006) (99)
- Antibiotics, peptidoglycan synthesis and genomics: the chlamydial anomaly revisited. (1998) (99)
- Bacterial RNA polymerase: a promising target for the discovery of new antimicrobial agents. (2007) (95)
- Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin (2009) (93)
- Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques (2004) (91)
- A Fusidic Acid-Resistant Epidemic Strain of Staphylococcus aureus Carries the fusB Determinant, whereas fusA Mutations Are Prevalent in Other Resistant Isolates (2004) (90)
- Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome (1991) (89)
- Uptake of minocycline by Escherichia coli. (1992) (88)
- Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes. (2002) (87)
- Transport of antibiotics into bacteria. (1982) (85)
- RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus (2000) (85)
- Bacterial resistance to the tetracyclines. (1978) (85)
- The 2012 Garrod lecture: discovery of antibacterial drugs in the 21st century. (2013) (84)
- Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli (1992) (84)
- Towards new business models for R&D for novel antibiotics. (2011) (83)
- Polymyxin B and polymyxin B nonapeptide alter cytoplasmic membrane permeability in Escherichia coli. (1986) (81)
- XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. (2010) (81)
- XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. (2009) (80)
- The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors (2009) (77)
- Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus. (2004) (77)
- Increased Mutability of Staphylococci in Biofilms as a Consequence of Oxidative Stress (2012) (73)
- Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center (2008) (73)
- Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. (2004) (73)
- Decreased uptake of cadmium by a resistant strain of Staphylococcus aureus. (1970) (72)
- Mechanisms of resistance to fusidic acid in Staphylococcus aureus. (1976) (69)
- Characterization of global patterns and the genetics of fusidic acid resistance. (2011) (65)
- New approaches to the control of infections caused by antibiotic-resistant bacteria. An industry perspective. (1996) (62)
- Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low. (2002) (60)
- Biological Properties of Novel Antistaphylococcal Quinoline-Indole Agents (2003) (60)
- Genetic studies of a multi-resistant strain of Staphylococcus aureus. (1974) (59)
- Functional and Biochemical Analysis of Chlamydia trachomatis MurC, an Enzyme Displaying UDP-N-Acetylmuramate:Amino Acid Ligase Activity (2003) (59)
- Anti-staphylococcal activity and mode of action of clofazimine. (2004) (57)
- Distribution of Fusidic Acid Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (2010) (56)
- High prevalence of resistance to fusidic acid in clinical isolates of Staphylococcus epidermidis. (2008) (55)
- Expression of the Staphylococcus aureusUDP-N-Acetylmuramoyl- l-Alanyl-d-Glutamate:l-Lysine Ligase in Escherichia coli and Effects on Peptidoglycan Biosynthesis and Cell Growth (1999) (55)
- Molecular action of anti-mycobacterial agents. (1997) (54)
- Antibiotic resistance in Staphylococcus aureus: concerns, causes and cures (2003) (54)
- Diffusion of tetracycline across the outer membrane of Escherichia coli K-12: involvement of protein Ia. (1978) (53)
- Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them (1985) (53)
- Antimicrobial activity and mechanisms of resistance to cephalosporin P1, an antibiotic related to fusidic acid. (2002) (52)
- The tetracyclines: prospects at the beginning of the 1980s. (1981) (51)
- Escherichia coli Mutators Present an Enhanced Risk for Emergence of Antibiotic Resistance during Urinary Tract Infections (2004) (50)
- Genetic analysis of the tetA(C) gene on plasmid pBR322 (1992) (50)
- Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening. (2009) (49)
- Assessment of a microplate method for determining the post-antibiotic effect in Staphylococcus aureus and Escherichia coli. (2004) (48)
- Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques. (2009) (47)
- Comparison of the polypeptide composition of Escherichia coli outer membranes prepared by two methods (1980) (46)
- A variety of Staphylococcal plasmids present as multiple copies. (1973) (46)
- Mechanism of Plasmid-Mediated Resistance to Cadmium in Staphylococcus aureus (1975) (45)
- The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden. (2003) (45)
- The antibacterial effects of low concentrations of antibiotics. (1986) (44)
- Bacterial resistance mechanisms as therapeutic targets. (1994) (44)
- Research and development of antibacterial agents. (1998) (44)
- Evidence for mutation to streptomycin resistance in clinical strains of Staphylococcus aureus. (1972) (43)
- Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes (1992) (39)
- Tetracycline analogs whose primary target is not the bacterial ribosome (1994) (38)
- A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. (2005) (38)
- Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD. (2003) (38)
- Evidence for more than one mechanism of plasmid-determined tetracycline resistance in Escherichia coli. (1980) (37)
- Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. (2008) (37)
- Origin of tetracycline efflux proteins: conclusions from nucleotide sequence analysis (1991) (35)
- Population Diversification in Staphylococcus aureus Biofilms May Promote Dissemination and Persistence (2013) (34)
- Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes (1983) (33)
- Efflux-based antibiotic resistance mechanisms: the evidence for increasing prevalence. (1992) (31)
- Affinities of β-Lactams for Penicillin Binding Proteins of Chlamydia trachomatis and Their Antichlamydial Activities (2001) (30)
- Functional and Biochemical Analysis of the Chlamydia trachomatis Ligase MurE (2009) (30)
- Mechanisms of the post-antibiotic effects induced by rifampicin and gentamicin in Escherichia coli. (2006) (30)
- Reduced expression of Tn 10-mediated tetracycline resistance in Escherichia coli containing more than one copy of the transposon. (1981) (30)
- Inhibition of Providencia stuartii cell envelope enzymes by chlorhexidine. (1987) (30)
- Intrinsic Novobiocin Resistance in Staphylococcus saprophyticus (2007) (29)
- Synthesis and Biological Evaluation of N‐Acylhydrazones as Inhibitors of MurC and MurD Ligases (2008) (29)
- Molecular mechanisms involved in the transport of antibiotics into bacteria (1988) (28)
- Inhibition of Escherichia coli K12 by short-chain organic acids: lack of evidence for induction of the SOS response. (1991) (28)
- Antibacterial activity and mode of action of tert-butylhydroquinone (TBHQ) and its oxidation product, tert-butylbenzoquinone (TBBQ). (2013) (28)
- 2-Aminotetralones: novel inhibitors of MurA and MurZ. (2008) (28)
- Effect of plasmid carriage on the virulence of staphylococcus aureus. (1975) (27)
- Antibacterial Agents: Basis of Action (2001) (27)
- Biochemical and Genetic Basis of Tetracycline Resistance in Staphylococcus aureus (1974) (27)
- Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem (2012) (27)
- Delayed Development of Linezolid Resistance in Staphylococcus aureus following Exposure to Low Levels of Antimicrobial Agents (2008) (26)
- Stabilization of Rhizobium symbiosis plasmids. (1999) (25)
- Genetic and biochemical basis of tetracycline resistance. (1986) (24)
- Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies. (2007) (24)
- Sensitive biological detection method for tetracyclines using a tetA-lacZ fusion system (1990) (24)
- Penicillin-binding protein 2 is required for induction of the Citrobacter freundii class I chromosomal beta-lactamase in Escherichia coli (1989) (24)
- Resistance to beta-lactams in Mycobacterium fortuitum (1992) (24)
- Activity of and Development of Resistance to Corallopyronin A, an Inhibitor of RNA Polymerase (2011) (23)
- Accumulation of tetracyclines by Escherichia coli K-12. (1977) (22)
- Mutations affecting penicillin-binding proteins 2a, 2b and 3 in Bacillus subtilis alter cell shape and peptidoglycan metabolism. (1987) (22)
- Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl). (2007) (22)
- Structure-based ligand design of novel bacterial RNA polymerase inhibitors. (2011) (21)
- Tetracycline resistance genes from Bacillus plasmid pAB124 confer decreased accumulation of the antibiotic in Bacillus subtilis but not in Escherichia coli (1981) (20)
- 6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase (2012) (20)
- Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase. (2011) (20)
- Use of Mutator Strains for Characterization of Novel Antimicrobial Agents (2001) (20)
- Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. (2011) (20)
- Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). (2010) (19)
- SB 205952, a novel semisynthetic monic acid analog with at least two modes of action (1995) (19)
- CHAPTER 2 – Modes of action (2010) (19)
- Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase (2010) (18)
- Over-expression of target genes as a mechanism of antibiotic resistance in bacteria. (1998) (18)
- The magainins: antimicrobial peptides with potential for topical application. (1993) (17)
- Tetracycline resistance determinants from groups A to D vary in their ability to confer decreased accumulation of tetracycline derivatives by Escherichia coli. (1982) (17)
- Induction of tetracycline resistance in Staphylococcus aureus in the absence of lipid synthesis. (1975) (16)
- Limitations of a fluorescence assay for studies on tetracycline transport into Escherichia coli (1983) (16)
- Energetics of tetracycline transport into Escherichia coli (1984) (16)
- Transcriptional Signature following Inhibition of Early-Stage Cell Wall Biosynthesis in Staphylococcus aureus (2009) (15)
- Lack of Evidence for Involvement of Hypermutability in Emergence of Vancomycin-Intermediate Staphylococcus aureus (2003) (15)
- Further Characterization of Bacillus subtilis Antibiotic Biosensors and Their Use for Antibacterial Mode-of-Action Studies (2011) (15)
- Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175). (2005) (14)
- Biochemical and genetic characterization of the tet determinant of Bacillus plasmid pAB124 (1984) (14)
- Antibiotic resistance resulting from decreased drug accumulation. (1984) (13)
- Composition of Membranes from Whole Cells and Minicells of Bacillus subtilis (1985) (13)
- Deletion of the Multiple-Drug Efflux Pump AcrAB in Escherichiacoli Prolongs the Postantibiotic Effect (2005) (12)
- Bacterial resistance to disinfectants, antiseptics and toxic metal ions (1991) (12)
- Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant resistant to the antibiotic. (1993) (12)
- Protein synthesis as a target for antibacterial drugs: current status and future opportunities. (1998) (11)
- Antibacterial spectra of drugs used for chemotherapy of mycobacterial infections. (1998) (11)
- Discovery and development of new anti-bacterial drugs (2002) (11)
- Lysozyme-promoted association of protein I molecules in the outer membrane of Escherichia coli (1977) (11)
- Inhibition of K88-mediated adhesion of Escherichia coli to mammalian receptors by antibiotics that affect bacterial protein synthesis. (1986) (10)
- Outer membrane composition in Escherichia coli and the poor activity of hydrophobic antibiotics against enteric bacteria. (1982) (9)
- Effects of tetracyclines on the production of extracellular proteins by members of the propionibacteriaceae. (1989) (9)
- Induction of the Citrobacter freundii group I beta-lactamase in Escherichia coli is not dependent on entry of beta-lactam into the cytoplasm (1990) (8)
- Zeocin resistance suppresses mutation in hypermutable Escherichia coli. (2003) (8)
- Tetracycline resistance in Escherichia coli K12 is not associated with a decrease in cyclopropane fatty acid content. (1977) (8)
- The Antimicrobial Drugs (2nd edn) (edited by E M Scholar and W B Pratt) (2001) (7)
- Transport of tetracyclines into Escherichia coli requires a carboxamide group at the C2 position of the molecule. (1986) (7)
- Evolution of extended-spectrum beta-lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator. (2006) (7)
- Resistance to ,-Lactams in Mycobacterium fortuitum (6)
- Comparison ofthePolypeptide Composition ofEscherichia coli Outer Membranes Prepared byTwoMethods (1980) (6)
- Susceptibility of protein synthesis in Escherichia coli to tetracycline and minocycline. (1981) (6)
- Prospects for antisense agents in the therapy of bacterial infections. (1999) (6)
- Bacterial resistance to the tetracyclines (1978) (6)
- Prediction of signal sequence-dependent protein translocation in bacteria: assessment of the Escherichia coli minicell system. (1988) (5)
- Inhibition of β-lactamase synthesis in Staphylococcus aureus by minocycline (1985) (5)
- Biochemical andGenetic Basis ofTetracycline Resistance in Staphylococcus aureus (1974) (4)
- Penetration of antibiotics to their target sites. (1990) (4)
- Mechanisms of resistance to antibiotics and other chemotherapeutic agents. (1988) (4)
- N-alkyl-substituted glycopeptide antibiotics. (1997) (3)
- Approaches to antibacterial drug discovery. (1997) (3)
- Analysis ofTetracycline Resistance Encoded byTransposon TnJO: Deletion Mapping ofTetracycline-Sensitive (1983) (3)
- Glycylcyclines - Third generation tetracycline analogues (1994) (3)
- Mecillinam has potent in vitro activity against Chlamydophila pneumoniae ATCC VR1310. (2004) (3)
- MINIREVIEW Molecular Basis of 3-Lactamase Induction in Bacteria (3)
- Exploiting current understanding of antibiotic action for discovery of new drugs. (2002) (2)
- Lack of correlation between methicillin resistance and susceptibility to lysostaphin in Staphylococcus aureus. (1974) (2)
- Plasmid-determined tetracycline resistance in Escherichia coli K12: lack of evidence that resistance is related to changes in lipid metabolism [proceedings]. (1978) (2)
- Structure of bacterial surfaces. (1989) (2)
- Monthly Update Anti-infectives: Progress in carbapenem research (1995) (2)
- Inhibition of K88ab-mediated haemagglutination by polymyxin B nonapeptide. (1991) (2)
- Uptake of tetracycline by Escherichia coli is not mediated by the sodium dependent glutamate transport system. (1990) (2)
- Chemotherapy of mycobacterial infections: molecular action of established drugs and investigational agents. (1998) (2)
- Lack of evidence for a saturable tetracycline transport system in Staphylococcus aureus (1991) (1)
- Chapter 141 – Tetracyclines and chloramphenicol (2010) (1)
- A well-targeted textbook: Biochemistry and Molecular Biology of Antimicrobial Drug Action (5th edn) by T.J. Franklin and G.A. Snow (2000) (1)
- Progress in carbapenem research (1995) (1)
- Antibiotics and bacterial adhesion. (1986) (1)
- A broad-spectrum approach to antimicrobials (2001) (1)
- Multiple isoelectric forms of bacterial penicillin-binding proteins: artefacts or genuine cellular components? (1988) (1)
- An assay to detect inhibitors of bacterial iron transport. (1994) (1)
- O262 The mode of action of daptomycin against Staphylococcus aureus (2007) (0)
- Outer membrane polypeptides and penicillin binding proteins in Citrobacter diversus (1987) (0)
- Fibronectin binding protein, monoclonal antibodies and their use in the prevention of adhesion of bacteria (1994) (0)
- CHAPTER 30 – Tetracyclines (2010) (0)
- MINIREVIEW Molecular Basisof 3-Lactamase Induction inBacteria (1993) (0)
- extended-spectrum b -lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator (2006) (0)
- Expression of pRW83 (penP) and pBR322-encoded β-lactamases in Escherichia coli (1987) (0)
- Monthly Update Anti-infectives: Molecular basis of resistance to anti-mycobacterial agents (1995) (0)
- Monthly Update: Anti-infectives: Ancient micro-organisms as a potential source of new antibiotics (1995) (0)
- Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem (2012) (0)
- Lysozyme-Promoted Association ofProtein IMolecules in theOuterMembraneofEscherichia coli (1977) (0)
- Mechanism ofPlasmid-Mediated Resistance toCadmiumin Staphylococcus aureus (1975) (0)
- Book reviewAntimicrobial agentsAntibiotic and Chemotherapy: Anti-Infective Agents and Their Use in Therapy, 7th edn, F. O'Grady, H.P. Lambert, R.G. Finch, D. Greenwood (Eds.), Churchill Livingstone (1997), ISBN: 0443052557 (1997) (0)
- Therapeutic regimens for the control of gastric diseases associated with infection by Helicobacter pylori (1994) (0)
- Update Anti-infectives Approaches to antibacterial drug discovery (1997) (0)
- Translational medicine for antibacterial drug development - A Marcus Evans conference: overcoming the challenge of proof of concept. (2008) (0)
- Monthly Update: Anti-infectives: Opportunities for discovery of new antibiotic targets arising from bacterial genome sequencing initiatives (1996) (0)
- Brief Reports on All Topics (1981) (0)
- Fractionation of the Providencia stuartii cell envelope. (1987) (0)
- Resistance during Urinary Tract Infections Enhanced Risk for Emergence of Antibiotic Mutators Present an Escherichia coli (2003) (0)
- New drugs for the chemotherapy of mycobacterial infections. (1999) (0)
- SHORT COMMUNICATION Decreased Uptake of Cadmium by a Resistant Strain of Staphylococcus aureus (1971) (0)
- Inhibition of staphylococcal growth by fusidic acid prevents production of volatile metabolites. (2000) (0)
- Inhibition of beta-lactamase synthesis in Staphylococcus aureus by minocycline. (1985) (0)
- Identification and characterization of novel peptidoglycan glycosyltransferase inhibitors with antibacterial activity (2009) (0)
- Paradoxical response and tolerance in a strain of Staphylococcus aureus. (1994) (0)
- METHOD DEVELOPMENT AND VALIDATION OF ZOPICLONE IN BULK AND TABLET DOSAGE FORM USING RP-HPLC (2015) (0)
- Anti-infectives: the way forward. (2002) (0)
- Fibronectin binding protein; monoclonal antibody and its use to prevent bacterial adhesion. (1994) (0)
- Chapter 15. Transport of Antibiotics into Bacteria (1989) (0)
- Antimicrobial chemotherapy. (1999) (0)
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What Schools Are Affiliated With Ian Chopra?
Ian Chopra is affiliated with the following schools:
