Ia John G. Reynolds
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(Suggest an Edit or Addition)Ia John G. Reynolds's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Glutamate-induced neuron death requires mitochondrial calcium uptake (1998) (633)
- Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure (1996) (621)
- Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures* (2000) (561)
- ΔΨm‐Dependent and ‐independent production of reactive oxygen species by rat brain mitochondria (2001) (549)
- Induction of Neuronal Apoptosis by Thiol Oxidation (2000) (361)
- Mitochondrial Trafficking to Synapses in Cultured Primary Cortical Neurons (2006) (360)
- Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons (2003) (337)
- Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration (2003) (322)
- 3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. (1987) (309)
- Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons (2006) (294)
- Brain voltage-sensitive calcium channel subtypes differentiated by ω-conotoxin fraction GVIA (1986) (282)
- Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation (2004) (272)
- DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. (2001) (262)
- Mitochondrial trafficking and morphology in healthy and injured neurons (2006) (231)
- Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. (1989) (225)
- Multiple sites for the regulation of the N-methyl-D-aspartate receptor. (1988) (218)
- Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. (2002) (207)
- MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants (2001) (199)
- Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. (1997) (198)
- Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation. (2004) (193)
- Tricyclic antidepressants block N‐methyl‐D‐aspartate receptors: similarities to the action of zinc (1988) (193)
- Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists. (1983) (192)
- Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria. (2005) (174)
- Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. (1994) (173)
- Calcium-antagonist drugs. Receptor interactions that clarify therapeutic effects. (1985) (162)
- Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons (1992) (160)
- Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease* (2010) (153)
- Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain. (1986) (148)
- Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. (1984) (147)
- Spontaneous Changes in Mitochondrial Membrane Potential in Cultured Neurons (2001) (145)
- Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons. (1998) (142)
- The Relationship between Intracellular Free Iron and Cell Injury in Cultured Neurons, Astrocytes, and Oligodendrocytes (2002) (138)
- Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity (2004) (132)
- Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons (1993) (129)
- Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture (2006) (124)
- Mechanisms of Dopamine-Induced Cell Death in Cultured Rat Forebrain Neurons: Interactions with and Differences from Glutamate-Induced Cell Death (1997) (115)
- Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death (2016) (108)
- [3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites. (1988) (108)
- Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. (1990) (105)
- Ca2+‐induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I (2005) (102)
- Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondria. (2003) (100)
- A reevaluation of neuronal zinc measurements: artifacts associated with high intracellular dye concentration. (2002) (100)
- Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo. (1989) (97)
- Calcium green-5N, a novel fluorescent probe for monitoring high intracellular free Ca2+ concentrations associated with glutamate excitotoxicity in cultured rat brain neurons (1993) (97)
- Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2 (2008) (92)
- Mitochondrial Membrane Potential and the Permeability Transition in Excitotoxicity (1999) (91)
- Direct visualization of mitochondrial zinc accumulation reveals uniporter‐dependent and ‐independent transport mechanisms (2005) (88)
- Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. (1990) (88)
- Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. (2008) (88)
- Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3. (2005) (86)
- Reduction of NMDA receptors with dithiothreitol increases [3H]‐MK‐801 binding and NMDA‐induced Ca2+ fluxes (1990) (86)
- High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations (1999) (86)
- (-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines. (1986) (85)
- A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease (2012) (83)
- Calcium‐Sensitive Fluorescent Dyes Can Report Increases in Intracellular Free Zinc Concentration in Cultured Forebrain Neurons (1998) (82)
- Characterization of Hydrogen Peroxide Toxicity in Cultured Rat Forebrain Neurons (1997) (82)
- Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. (1994) (81)
- Effects of Oxidants and Glutamate Receptor Activation on Mitochondrial Membrane Potential in Rat Forebrain Neurons (1998) (78)
- Regional Variations in [3H]MK801 Binding to Rat Brain N‐Methyl‐D‐Aspartate Receptors (1991) (78)
- Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca2+]i increases and NMDA receptor mRNA levels (1999) (76)
- Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neuronsin vitro: Effect of chemical ischemia (1994) (76)
- Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus (2001) (75)
- NMDA Receptor‐Mediated Neurotoxicity: A Paradoxical Requirement for Extracellular Mg2+ in Na+/Ca2+‐Free Solutions in Rat Cortical Neurons In Vitro (1997) (75)
- Mitochondrial trafficking and morphology in neuronal injury. (2010) (73)
- Astrocytes Are More Resistant Than Neurons to the Cytotoxic Effects of Increased [Zn2+]i (2000) (71)
- Zn2+ Inhibits Mitochondrial Movement in Neurons by Phosphatidylinositol 3-Kinase Activation (2005) (71)
- Alterations in Calcium Antagonist Receptors and Sodium-Calcium Exchange in Cardiomyopathic Hamster Tissues (1989) (66)
- Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential (2006) (65)
- Oxidized glutathione modulates N-methyl-d-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons (1991) (59)
- Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders (2014) (58)
- PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. (2004) (58)
- Mechanisms of glutamate‐stimulated Mg2+ influx and subsequent Mg2+ efflux in rat forebrain neurones in culture. (1996) (57)
- Divergent consequences arise from metallothionein overexpression in astrocytes: Zinc buffering and oxidant‐induced zinc release (2004) (56)
- Trifluoperazine and dibucaine‐induced inhibition of glutamate‐induced mitochondrial depolarization in rat cultured forebrain neurones (1997) (55)
- Nuclear and Mitochondrial Interaction Involving mt-Nd2 Leads to Increased Mitochondrial Reactive Oxygen Species Production* (2007) (54)
- Alkalinization Prolongs Recovery from Glutamate‐Induced Increases in Intracellular Ca2+ Concentration by Enhancing Ca2+ Efflux Through the Mitochondrial Na+/Ca2+ Exchanger in Cultured Rat Forebrain Neurons (1998) (54)
- Modulation of NMDA receptor responsiveness by neurotransmitters, drugs and chemical modification. (1990) (54)
- Effects of nicotinic agonists on the NMDA receptor (1991) (53)
- Brain voltage-sensitive calcium channel subtypes differentiated by omega-conotoxin fraction GVIA. (1986) (50)
- Orally administered progesterone enhances sensitivity to triazolam in postmenopausal women. (1995) (50)
- Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures (2005) (50)
- Distinct characteristics of Ca(2+)-induced depolarization of isolated brain and liver mitochondria. (2005) (50)
- The role of intracellular Na+ and mitochondria in buffering of kainate‐induced intracellular free Ca2+ changes in rat forebrain neurones (1998) (49)
- [3H]MK801 binding to the N-methyl-D-aspartate receptor reveals drug interactions with the zinc and magnesium binding sites. (1988) (48)
- Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons. (1997) (46)
- [3H]Verapamil binding sites in brain and skeletal muscle: regulation by calcium. (1983) (46)
- Fluctuations in mitochondrial membrane potential in single isolated brain mitochondria: modulation by adenine nucleotides and Ca2+. (2004) (44)
- Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative and memory effects. (1997) (44)
- Allosteric modulation of N-methyl-D-aspartate receptors. (1990) (43)
- Glutamate mobilizes [Zn2+]i through Ca2+‐dependent reactive oxygen species accumulation (2008) (43)
- Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. (1998) (43)
- Mitochondrial Trafficking in Neurons: A Key Variable in Neurodegeneration? (2004) (42)
- Glucose deprivation produces a prolonged increase in sensitivity to glutamate in cultured rat cortical neurons (2003) (40)
- NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release. (1989) (38)
- Direct and allosteric control of glutamate receptors (1994) (37)
- New perspectives on mitochondrial morphology in cell function (2003) (37)
- [3H] CGP 39653 Binding to the Agonist Site of the N‐Methyl‐ D‐Aspartate Receptor Is Modulated by Mg2+ and Polyamines Independently of the Arcaine‐Sensitive Polyamine Site (1994) (36)
- Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity. (2012) (35)
- Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion. (2002) (34)
- Synthesis and bioactivity of a new class of rigid glutamate analogues. Modulators of the N-methyl-D-aspartate receptor. (1990) (33)
- Calcium Channel Blockade: Possible Explanation for Thioridazine's Peripheral Side Effects (1984) (32)
- Cyclothiazide Modulates AMPA Receptor‐Mediated Increases in Intracellular Free Ca2+ and Mg2+ in Cultured Neurons from Rat Brain (1995) (31)
- Calcium antagonist receptors. Clinical and physiological relevance. (1988) (31)
- Muscarinic Agonists Cause Calcium Influx and Calcium Mobilization in Forebrain Neurons In Vitro (1989) (31)
- Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons. (2000) (31)
- Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents (1993) (28)
- Pharmacological investigation of mitochondrial ca(2+) transport in central neurons: studies with CGP-37157, an inhibitor of the mitochondrial Na(+)-Ca(2+) exchanger. (2000) (28)
- Mitochondrial Stop and Go: Signals That Regulate Organelle Movement (2004) (27)
- The targeted eosinophil-lowering effects of dexpramipexole in clinical studies. (2017) (27)
- Calcium antagonist receptors. (1988) (26)
- Elevated intracellular zinc and altered proton homeostasis in forebrain neurons (2002) (24)
- H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine ( N-methyl-n-aspartate receptor / fura-2 ) (24)
- Nitric oxide decreases the sensitivity of pulmonary endothelial cells to LPS-induced apoptosis in a zinc-dependent fashion (2004) (23)
- Effect of neuroactive steroids on [3H]flumazenil binding to the GABAA receptor complex in vitro (1995) (22)
- Subcellular localization of glutamate-stimulated intracellular magnesium concentration changes in cultured rat forebrain neurons using confocal microscopy (1999) (21)
- Intracellular calcium and magnesium: critical determinants of excitotoxicity? (1998) (20)
- The spider toxin, argiotoxin636, binds to a Mg2+ site on the N‐methyl‐d‐aspartate receptor complex (1991) (19)
- 1,5-(Diethylamino)piperidine, a novel spermidine analogue that more specifically activates the N-methyl-D-aspartate receptor-associated polyamine site. (1992) (18)
- Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors. (1999) (18)
- Calcium channel blockade: possible explanation for thioridazine's peripheral side effects. (1984) (18)
- Synaptosomal dopamine uptake in rat striatum following controlled cortical impact (2005) (17)
- Excitatory amino acid receptors: NMDA modulatory sites, kainate cloned and a new role in AIDS (1990) (14)
- Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation (2004) (14)
- Calcium influx but not pH or ATP level mediates glutamate-induced changes in intracellular magnesium in cortical neurons. (1995) (14)
- Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine. (1992) (13)
- The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction (2021) (13)
- Effects of Monovalent and Divalent Cations on 3‐(+)[125I]Iododizocilpine Binding to the N‐Methyl‐d‐Aspartate Receptor of Rat Brain Membranes (1992) (12)
- Fluorescence Detection of Redox‐Sensitive Metals in Neuronal Culture: Focus on Iron and Zinc (2004) (11)
- Effects of pH on the actions of dizocilpine at the N‐methyl‐D‐aspartate receptor complex (1993) (11)
- Characterization of the effects of polyamines on the modulation of the N-methyl-d-aspartate receptor by glycine (1995) (10)
- The use of ligand binding in assays of NMDA receptor function. (1999) (10)
- 1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo. (1991) (10)
- Apoptosis and the laws of thermodynamics (2000) (9)
- Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice. (2014) (9)
- Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor. (1998) (9)
- [3H](+)MK801 Radioligand Binding Assay at the N‐Methyl‐D‐Aspartate Receptor (2000) (9)
- Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists. (1999) (9)
- Studies on the effects of several pentamidine analogues on the NMDA receptor. (1993) (8)
- The Redox Biology of Excitotoxic Processes: The NMDA Receptor, TOPA Quinone, and the Oxidative Liberation of Intracellular Zinc (2020) (8)
- Localization of D1 dopamine receptors on live cultured striatal neurons by quantitative fluorescence microscopy (1996) (8)
- [125I]thienylphencyclidine, a novel ligand for the NMDA receptor. (1992) (8)
- Effects of age and visual experience on [3H] MK801 binding to NMDA receptors in the kitten visual cortex (2004) (7)
- Measurement of Cation Movement in Primary Cultures Using Fluorescent Dyes (1998) (7)
- Physiological and Pharmacological Correlates of Calcium Antagonist Receptors (1987) (7)
- 4.7 Ion Transport and Energy Metabolism (2007) (6)
- Synthesis and evaluation of fluoromycin: a novel fluorescence-labeled derivative of talisomycin S10b. (1992) (6)
- Molecular Zn 2 Inhibits Mitochondrial Movement in Neurons by Phosphatidylinositol 3-Kinase Activation (2005) (5)
- Mitochondria in Acute Brain Injury (2001) (5)
- Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency. (1992) (5)
- Zinc causes loss of membrane potential and alters production of reactive oxygen species in isolated brain mitochondria (2008) (4)
- Modulation of NMDA Excitotoxicity by Redox Reagents a (1992) (4)
- High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays. (2011) (3)
- Interaction of rigid polyamine analogues with the NMDA receptor complex from rat brain (1993) (2)
- Erratum: Epidermal growth factor activates m-Calpain (Calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation (Molecular and Cellular Biology (2004) 24, 6 (2499-2512)) (2004) (2)
- Role of the Permeability Transition in Glutamate-Mediated Neuronal Injury (2002) (2)
- Intracellular Signalling in Glutamate Excitotoxicity (1996) (2)
- A Characterization of Dopaminergic Neurodegeneration in Organotypic Cultures (2003) (2)
- PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ. (2010) (2)
- Desensitization of 5HT2 Receptors by Protein Kinase C Activation in Distal Pulmonary Vascular Smooth Muscle Cells in Culture (1994) (2)
- Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site (1998) (2)
- Mitochondrial Mechanisms of Neuronal Injury (2002) (1)
- A potent and selective mGluR4 positive allosteric modulator improves movement in rodent models of Parkinson's disease (2012) (1)
- The Neuropharmacology of Ca2+ Channels (1988) (1)
- Symposium S07: Zinc in Neurodegeneration (2003) (0)
- Brain voltage-sensitive calcium channel subtypes differentiated by a-conotoxin fraction GVIA ( calcium uptake / calcium antagonist / neurotransmitter release / fura-2 ) (1999) (0)
- Apolipoprotein E4-induced mitochondrial dysfunction depends on its structure and can be rescued by a structure corrector (2009) (0)
- Novel mGluR4 Radioligands Reveal Distinct Sites for Positive Allosteric Modulators (2010) (0)
- CHAPTER 10:Glutamate Receptor Modulators as Emergent Therapeutic Agents in the Treatment of Parkinson’s Disease (2013) (0)
- Synthesis of a Potent Wide‐Spectrum Serotonin‐, Norepinephrine‐, Dopamine‐Reuptake Inhibitor (SNDRI) and a Species‐Selective Dopamine‐Reuptake Inhibitor Based on the Gamma‐Amino Alcohol Functional Group. (1998) (0)
- Preparation and Properties of Mononuclear Vanadium Thiolates : Structural Characterization of the [ V ( SBut ) , l 0 ' Pair and CS Bond Cleavage in V ( SBU ' ) ~ in the Gas Phase (2001) (0)
- Differential Localization of Glutamate Receptor Subunits at the Drosophila Neuromuscular Junction (2004) (0)
- Interaction between mitochondria and oxidative stress in neuronal injury (2003) (0)
- P2.003 Selective spatial learning impairments and attention deflcits precede a frank motor phenotype in a mouse model of Parkinson's disease (2009) (0)
- Manifestations of Drug Toxicity on Mitochondria in the Nervous System (2008) (0)
- Effects of rigid analogs of arcaine on the polyamine site of the NMDA receptor complex (1994) (0)
- Aromatic Analogues of Arcaine Inhibit MK-801 Binding to the NMDA Receptor. (1999) (0)
- Synthesis and Evaluation of Fluoromycin: A Novel Fluorescence-labeled Derivative of Talisomycin Siot,1 (2006) (0)
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