Ian Orme

Q: What Schools Are Affiliated With Ian Orme

Ian Orme is affiliated with the following schools: University of Porto, University of Oxford, University of Colorado Denver, Colorado State University

Ian Orme's AcademicInfluence.com Rankings

Ian Orme

Biology

#6638

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#9401

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Microbiology

#315

World Rank

#361

Historical Rank

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Biology

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According to Wikipedia, Ian Orme was a British-American microbiologist who was a Distinguished Professor at Colorado State University.

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Ian Orme's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Disseminated tuberculosis in interferon gamma gene-disrupted mice (1993) (2050)
Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis (1997) (776)
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine (1996) (688)
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens (2008) (594)
T cell response to Mycobacterium tuberculosis. (1993) (445)
An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis. (1998) (420)
Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. (1994) (386)
Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. (1993) (386)
The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. (1995) (347)
Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present1 (2002) (339)
The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. (1987) (324)
Neutrophils Play a Protective Nonphagocytic Role in Systemic Mycobacterium tuberculosis Infection of Mice (2000) (319)
An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis. (1997) (307)
Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness. (2004) (304)
In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice1 (2002) (301)
Differential Immune Responses and Protective Efficacy Induced by Components of a Tuberculosis Polyprotein Vaccine, Mtb72F, Delivered as Naked DNA or Recombinant Protein1 (2004) (301)
Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis. (1997) (297)
Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models (2005) (296)
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. (2007) (295)
Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis (1998) (285)
Disseminated Tuberculosis in Interferon 7 Gene-disrupted Mice (2003) (281)
Cu,Zn Superoxide Dismutase of Mycobacterium tuberculosis Contributes to Survival in Activated Macrophages That Are Generating an Oxidative Burst (2001) (280)
A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis (2010) (271)
Cytokine/chemokine cascades in immunity to tuberculosis. (1999) (270)
T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens. (1992) (264)
The Hypervirulent Mycobacterium tuberculosis Strain HN878 Induces a Potent TH1 Response followed by Rapid Down-Regulation1 (2007) (252)
Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910 (2007) (246)
Adoptive protection of the Mycobacterium tuberculosis-infected lung. Dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin. (1984) (239)
Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance in mice inoculated with killed mycobacterial vaccines (1988) (239)
Dynamics of Macrophage Cell Populations During Murine Pulmonary Tuberculosis 1 (2003) (228)
Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor (1992) (228)
The balance between protective and pathogenic immune responses in the TB-infected lung (2014) (223)
Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection. (1988) (221)
Interleukin-6 Induces Early Gamma Interferon Production in the Infected Lung but Is Not Required for Generation of Specific Immunity to Mycobacterium tuberculosisInfection (2000) (219)
NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection 1 (2003) (198)
Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. (1995) (197)
The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms (1997) (192)
Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection (1994) (191)
Characterization of Murine Lung Dendritic Cells Infected with Mycobacterium tuberculosis (2001) (189)
Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients (1983) (188)
A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis (2011) (183)
Transient Loss of Resistance to Pulmonary Tuberculosis in p47phox−/− Mice (2000) (183)
Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. (2012) (183)
Immunopathogenesis of Pulmonary Granulomas in the Guinea Pig after Infection with Mycobacterium tuberculosis (2003) (181)
Chemokine response in mice infected with Mycobacterium tuberculosis (1995) (180)
The Protective Effect of the Mycobacterium bovis BCG Vaccine Is Increased by Coadministration with the Mycobacterium tuberculosis 72-Kilodalton Fusion Polyprotein Mtb72F in M. tuberculosis-Infected Guinea Pigs (2004) (179)
Disruption of granulocyte macrophage‐colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection (2005) (178)
Role for Matrix Metalloproteinase 9 in Granuloma Formation during Pulmonary Mycobacterium tuberculosis Infection (2006) (172)
CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. (2002) (167)
Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys (2009) (159)
Temporal and Spatial Arrangement of Lymphocytes within Lung Granulomas Induced by Aerosol Infection withMycobacterium tuberculosis (2001) (158)
Tuberculosis vaccine development: recent progress. (2001) (155)
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis (1996) (149)
The formation of the granuloma in tuberculosis infection. (2014) (147)
Expression of the Nitric Oxide Synthase 2 Gene Is Not Essential for Early Control of Mycobacterium tuberculosis in the Murine Lung (2000) (143)
Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages (2006) (137)
Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae (1997) (135)
Pulmonary Necrosis Resulting from DNA Vaccination against Tuberculosis (2003) (130)
Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice (1995) (127)
T Cell Expression Cloning of a Mycobacterium tuberculosis Gene Encoding a Protective Antigen Associated with the Early Control of Infection1 (2000) (126)
Animal model of Mycobacterium abscessus lung infection (2008) (124)
The immunopathogenesis of tuberculosis: a new working hypothesis. (1998) (121)
Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. (2001) (121)
A new unifying theory of the pathogenesis of tuberculosis. (2014) (120)
Boosting Vaccine for Tuberculosis (2001) (116)
Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection (2009) (116)
Preclinical testing of new vaccines for tuberculosis: a comprehensive review. (2006) (115)
Effective Preexposure Tuberculosis Vaccines Fail To Protect When They Are Given in an Immunotherapeutic Mode (2000) (115)
Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis (2011) (112)
Differential polarization of alveolar macrophages and bone marrow‐derived monocytes following chemically and pathogen‐induced chronic lung inflammation (2010) (110)
CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis. (2001) (108)
Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection. (2009) (107)
Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models. (2011) (107)
Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis (1996) (107)
The mouse as a useful model of tuberculosis. (2003) (107)
The application of proteomics in defining the T cell antigens of Mycobacterium tuberculosis (2001) (106)
Immunity to mycobacteria. (1995) (105)
Foamy Macrophages within Lung Granulomas of Mice Infected with Mycobacterium tuberculosis Express Molecules Characteristic of Dendritic Cells and Antiapoptotic Markers of the TNF Receptor-Associated Factor Family1 (2005) (104)
Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages. (1993) (103)
Listeria monocytogenes infection in beta 2 microglobulin-deficient mice (1993) (102)
The Achilles heel of BCG. (2010) (101)
Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family. (1999) (100)
Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates (1997) (100)
Temporal and Spatial Arrangement of Lymphocytes within Lung Granulomas Induced by Aerosol Infection with Mycobacterium tuberculosis (2001) (98)
‘ Protection of synapses against Alzheimer ’ slinked toxins : Insulin signaling prevents the pathogenic binding of A oligomers (2009) (98)
Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. (1997) (97)
A mouse model of the recrudescence of latent tuberculosis in the elderly. (1988) (96)
Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis (2010) (94)
Rapid In Vivo Screening of Experimental Drugs for Tuberculosis Using Gamma Interferon Gene-Disrupted Mice (2003) (93)
Aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes. (1987) (92)
Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model. (2008) (90)
Adequate Expression of Protective Immunity in the Absence of Granuloma Formation in Mycobacterium tuberculosis-Infected Mice with a Disruption in the Intracellular Adhesion Molecule 1 Gene (1998) (89)
Metronidazole Therapy in Mice Infected with Tuberculosis (1999) (88)
Preclinical testing of new drugs for tuberculosis: current challenges. (2008) (87)
Beijing Sublineages of Mycobacterium tuberculosis Differ in Pathogenicity in the Guinea Pig (2012) (87)
Search for New Drugs for Treatment of Tuberculosis (2001) (86)
Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity (2013) (86)
The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo (2004) (86)
Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis (1994) (83)
Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis. (1997) (83)
Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A. (1999) (82)
Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis (2003) (80)
Memory T Lymphocytes Generated by Mycobacterium bovis BCG Vaccination Reside within a CD4 CD44lo CD62 Ligandhi Population (2005) (79)
Kinetics of accumulation of gamma delta receptor-bearing T lymphocytes in mice infected with live mycobacteria (1991) (79)
Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis (2010) (79)
Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis. (2011) (79)
The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4 (2001) (78)
The Cellular Immune Response to Mycobacterium tuberculosis Infection in the Guinea Pig1 (2007) (78)
Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease. (2010) (78)
A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. (2000) (78)
Disruption of the Cellular Inflammatory Response to Listeria monocytogenes Infection in Mice with Disruptions in Targeted Genes (1998) (77)
Pulmonary Lymphatics Are Primary Sites of Mycobacterium tuberculosis Infection in Guinea Pigs Infected by Aerosol (2006) (77)
Sulfolipid Deficiency Does Not Affect the Virulence of Mycobacterium tuberculosis H37Rv in Mice and Guinea Pigs (2003) (77)
Comparative Studies Evaluating Mouse Models Used for Efficacy Testing of Experimental Drugs against Mycobacterium tuberculosis (2010) (76)
Immunological Basis for Reactivation of Tuberculosis in Mice (2001) (75)
Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs. (2009) (74)
Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection. (2003) (72)
Beyond BCG: the potential for a more effective TB vaccine. (1999) (70)
Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis (1995) (70)
CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection (1999) (69)
Mouse Model of Tuberculosis (1994) (69)
Relative Levels of M-CSF and GM-CSF Influence the Specific Generation of Macrophage Populations during Infection with Mycobacterium tuberculosis1 (2008) (69)
Efficacy of Mycobacterium bovis BCG vaccination in mice undergoing prior pulmonary infection with atypical mycobacteria (1984) (69)
Lack of Protection in Mice and Necrotizing Bronchointerstitial Pneumonia with Bronchiolitis in Guinea Pigs Immunized with Vaccines Directed against the hsp60 Molecule ofMycobacterium tuberculosis (2000) (68)
Host Response to Nontuberculous Mycobacterial Infections of Current Clinical Importance (2014) (67)
Rapid Accumulation of Eosinophils in Lung Lesions in Guinea Pigs Infected with Mycobacterium tuberculosis (2004) (67)
Mycobacterium bovis BCG-Mediated Protection against W-Beijing Strains of Mycobacterium tuberculosis Is Diminished Concomitant with the Emergence of Regulatory T Cells (2011) (67)
Determination of lesion volume by MRI and stereology in a macaque model of tuberculosis. (2009) (66)
Molecular Characterization and Human T-Cell Responses to a Member of a Novel Mycobacterium tuberculosis mtb39Gene Family (1999) (66)
Development of new vaccines and drugs for TB: limitations and potential strategic errors. (2011) (65)
Evaluation of new vaccines for tuberculosis in the guinea pig model. (2009) (63)
Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis. (2009) (63)
Capacity of Mycobacterium avium isolates to grow well or poorly in murine macrophages resides in their ability to induce secretion of tumor necrosis factor (1992) (62)
Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection (2013) (62)
DNA vaccines against tuberculosis. (1998) (61)
Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein (2005) (60)
Dissemination of enteric Mycobacterium avium infections in mice rendered immunodeficient by thymectomy and CD4 depletion or by prior infection with murine AIDS retroviruses (1992) (60)
Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis (2005) (59)
Vaccine Development for Tuberculosis: Current Progress (2013) (58)
Magnetic Resonance Imaging of Pulmonary Lesions in Guinea Pigs Infected with Mycobacterium tuberculosis (2004) (55)
Vaccination of Cattle with Mycobacterium bovis Culture Filtrate Proteins and Interleukin-2 for Protection against Bovine Tuberculosis (2000) (55)
Influence of Mycobacterium bovis BCG Vaccination on Cellular Immune Response of Guinea Pigs Challenged with Mycobacterium tuberculosis (2008) (54)
XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN‐γ by CD4 T cells and participates in granuloma stability (2007) (54)
Role of γδ T Cells in Immunopathology of Pulmonary Mycobacterium avium Infection in Mice (1998) (54)
Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis. (2006) (54)
Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice. (2011) (53)
Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations. (2006) (53)
Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. (2014) (52)
Activities of TMC207, Rifampin, and Pyrazinamide against Mycobacterium tuberculosis Infection in Guinea Pigs (2010) (51)
Current progress in tuberculosis vaccine development. (2005) (51)
In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation. (1992) (51)
Old Mice Express a Transient Early Resistance to Pulmonary Tuberculosis That Is Mediated by CD8 T Cells (2002) (51)
Gamma Interferon Production by Bovine γδ T Cells following Stimulation with Mycobacterial Mycolylarabinogalactan Peptidoglycan (2004) (50)
Mouse and guinea pig models for testing new tuberculosis vaccines. (2005) (49)
Enhanced Macrophage Activity in Granulomatous Lesions of Immune Mice Challenged with Mycobacterium tuberculosis1 (2006) (49)
Role of mononuclear phagocytes in expression of resistance and susceptibility to Mycobacterium avium infections in mice (1986) (49)
Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity. (2014) (49)
Animal Models of Mycobacteria Infection (1999) (48)
The search for new vaccines against tuberculosis (2001) (48)
BCG: myths, realities, and the need for alternative vaccine strategies. (2012) (48)
Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis. (2011) (48)
Memory T cell subsets in tuberculosis: what should we be targeting? (2014) (48)
Genetic control of natural resistance to nontuberculous mycobacterial infections in mice (1986) (48)
Stable T-Cell Population Expressing an Effector Cell Surface Phenotype in the Lungs of Mice Chronically Infected with Mycobacterium tuberculosis (2004) (47)
Adaptive immunity to mycobacteria. (2004) (47)
Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis. (2012) (46)
The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy. (2002) (46)
Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis (2015) (44)
Rapid Microbiologic and Pharmacologic Evaluation of Experimental Compounds against Mycobacterium tuberculosis (2006) (44)
A Toll-Like Receptor-2-Directed Fusion Protein Vaccine against Tuberculosis (2007) (44)
Crossprotection against nontuberculous mycobacterial infections by Mycobacterium tuberculosis memory immune T lymphocytes (1986) (44)
A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions (1994) (43)
Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig. (2008) (42)
New vaccines against tuberculosis. The status of current research. (1999) (42)
Homologated aza analogs of arabinose as antimycobacterial agents. (1998) (42)
Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon‐γ (2006) (42)
T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis. (2011) (42)
Effective, Nonsensitizing Vaccination with Culture Filtrate Proteins against Virulent Mycobacterium bovis Infections in Mice (1998) (41)
Factors Associated with Severe Granulomatous Pneumonia in Mycobacterium tuberculosis-Infected Mice Vaccinated Therapeutically with hsp65 DNA (2005) (41)
Tuberculosis Vaccine Types and Timings (2014) (40)
Granuloma Formation in Mouse and Guinea Pig Models of Experimental Tuberculosis (2003) (40)
Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease. (2009) (39)
Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis. (1993) (39)
Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104. (2002) (39)
Effect of rifabutin on disseminated Mycobacterium avium infections in thymectomized, CD4 T-cell-deficient mice (1990) (39)
Demonstration of acquired resistance in Bcgr inbred mouse strains infected with a low dose of BCG montreal. (1984) (39)
Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs. (2005) (39)
Uptake and Accumulation of Oxidized Low-Density Lipoprotein during Mycobacterium tuberculosis Infection in Guinea Pigs (2012) (39)
A new antibiotic with potent activity targets MscL (2015) (38)
Prophylactic effect in mice of BCG vaccination against nontuberculous mycobacterial infections. (1985) (38)
The use of animal models to guide rational vaccine design. (2005) (37)
The role of CD8+ T cells in immunity to tuberculosis infection. (1993) (37)
Aerogenic vaccination of mice with Mycobacterium bovis BCG. (1986) (36)
SWR Mice Are Highly Susceptible to Pulmonary Infection with Mycobacterium tuberculosis (2003) (35)
Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis (2008) (35)
Animal Models of Tuberculosis: An Overview. (2016) (34)
Prospects for new vaccines against tuberculosis. (1995) (34)
NIH pre-clinical screening program: overview and current status. (2005) (34)
Lack of evidence for a reduction in the efficacy of subcutaneous BCG vaccination in mice infected with nontuberculous mycobacteria. (1986) (34)
MURINE MODEL OF TUBERCULOSIS (2002) (34)
Similar responses by macrophages from young and old mice infected with Mycobacterium tuberculosis (1998) (34)
Resistance of various strains of mycobacteria to killing by activated macrophages in vivo. (1983) (33)
Mouse and Guinea Pig Models of Tuberculosis. (2016) (33)
The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-γ) but not IFN type I (2004) (32)
Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis (1995) (32)
Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning. (2009) (32)
Immune response to atypical mycobacteria: immunocompetence of heavily infected mice measured in vivo fails to substantiate immunosuppression data obtained in vitro (1984) (32)
The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis (2015) (31)
Characterization of the protective T‐cell response generated in CD4‐deficient mice by a live attenuated Mycobacterium tuberculosis vaccine (2007) (31)
Mice Fed Lipid-Encapsulated Mycobacterium bovis BCG Are Protected against Aerosol Challenge with Mycobacterium tuberculosis (2005) (31)
Importance of Confirming Data on the In Vivo Efficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis (2011) (30)
Dose of BCG does not influence the efficient generation of protective immunity in mice challenged with Mycobacterium tuberculosis. (2002) (30)
A mouse model of tuberculosis reinfection. (2012) (30)
Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis. (2002) (30)
Use of Specific rRNA Oligonucleotide Probes for Microscopic Detection of Mycobacterium tuberculosis in Culture and Tissue Specimens (2005) (29)
Murine Models of Tuberculosis (1999) (29)
Immunopathogenesis of Mycobacterium avium infection. (1998) (26)
Inhibitors of prostaglandin synthetase block the generation of suppressor T cells induced by concanavalin A. (1981) (26)
A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties. (2007) (25)
Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates. (2004) (25)
Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule (2003) (25)
Acquired immunity to heavy infection with Mycobacterium bovis bacillus Calmette-Guérin and its relationship to the development of nonspecific unresponsiveness in vitro. (1984) (25)
Immune responses in animal models. (1996) (24)
Mechanisms underlying the increased susceptibility of aged mice to tuberculosis. (2009) (24)
Interleukin‐10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis (2005) (24)
Role of gamma delta T cells in immunopathology of pulmonary Mycobacterium avium infection in mice. (1998) (23)
Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis. (2002) (23)
Evaluation of Once-Weekly Therapy for Tuberculosis Using Isoniazid plus Rifamycins in the Mouse Aerosol Infection Model (1998) (23)
Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan. (2004) (22)
Correction: Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection (2009) (22)
Tuberculosis vaccines: current progress. (2005) (22)
Evaluation of a 2-Pyridone, KRQ-10018, against Mycobacterium tuberculosis In Vitro and In Vivo (2008) (22)
Active and memory immunity to Listeria monocytogenes infection in mice is mediated by phenotypically distinct T-cell populations. (1989) (22)
Prevalence of serum antibody to the type-specific glycopeptidolipid antigens of Mycobacterium avium in human immunodeficiency virus-positive and -negative individuals (1991) (21)
Progress in the development of new vaccines against tuberculosis. (1997) (21)
In Vivo Adaptation of the Wayne Model of Latent Tuberculosis (2007) (20)
Safety issues regarding new vaccines for tuberculosis, with an emphasis on post-exposure vaccination. (2006) (19)
Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis. (2012) (19)
Induction of immunity by DNA vaccination: application to influenza and tuberculosis. (1997) (19)
Protection of mice and guinea pigs against tuberculosis induced by immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41. (2005) (18)
Vaccines to prevent tuberculosis infection rather than disease: Physiological and immunological aspects. (2016) (18)
Efficacy and safety of live recombinant BCG vaccines. (1995) (18)
A Limited Antigen-Specific Cellular Response Is Sufficient for the Early Control of Mycobacterium tuberculosis in the Lung but Is Insufficient for Long-Term Survival (2004) (18)
Animal Models of M. tuberculosis Infection (2007) (18)
Transient Loss of Resistance to Pulmonary Tuberculosis in p 47 phox 2 / 2 Mice (2000) (17)
Virulence of recent notorious Mycobacterium tuberculosis isolates. (1999) (17)
Differential Mycobacterium bovis BCG Vaccine-Derived Efficacy in C3Heb/FeJ and C3H/HeOuJ Mice Exposed to a Clinical Strain of Mycobacterium tuberculosis (2014) (17)
Immunology and vaccinology of tuberculosis: can lessons from the mouse be applied to the cow? (2001) (17)
Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay. (2011) (17)
Immunodeficiency and infantile bone and joint infection. (1975) (16)
Post-exposure vaccination against Mycobacterium tuberculosis. (2009) (16)
bis-Molybdopterin Guanine Dinucleotide Is Required for Persistence of Mycobacterium tuberculosis in Guinea Pigs (2014) (16)
Activities of rifabutin, clarithromycin, and ethambutol against two virulent strains of Mycobacterium avium in a mouse model (1995) (16)
Protective and memory immunity in mice infected with Mycobacterium tuberculosis. (1994) (15)
The immune response to the cell wall of Mycobacterium bovis BCG. (1988) (15)
Antimycobacterial activity in vivo of LM427 (rifabutin). (1988) (15)
Vaccination against tuberculosis: recent progress. (1999) (15)
Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor (1993) (14)
Evidence for a biphasic memory T-cell response to high dose BCG vaccination in mice. (1988) (13)
Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry. (2009) (13)
Patterns of IL-2 production and utilization in mice heavily infected with Mycobacterium bovis BCG reflect the phase of protective immunity being expressed. (1989) (13)
Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis (2018) (13)
Immunization with f-Met peptides induces immune reactivity against Mycobacterium tuberculosis. (2000) (12)
The Endothelin System Has a Significant Role in the Pathogenesis and Progression of Mycobacterium tuberculosis Infection (2014) (12)
Incorporation of CpG oligodeoxynucleotide fails to enhance the protective efficacy of a subunit vaccine against Mycobacterium tuberculosis. (2004) (12)
Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection. (1998) (12)
Mycobacterium tuberculosis-driven processes in gene-disrupted mice (1997) (12)
Activities of TMC 207 , Rifampin , and Pyrazinamide against Mycobacterium tuberculosis Infection in Guinea Pigs (2010) (11)
GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis (2017) (11)
Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis. (2014) (10)
T cell response in acquired protective immunity to Mycobacterium tuberculosis infection. (1991) (10)
Reduced in vivo nonspecific resistance to Listeria monocytogenes infection during avian retrovirus-induced immunosuppression. (1988) (10)
Cortisone-Forced Reactivation of Weakly Acid Fast Positive Mycobacterium Tuberculosis in Guinea Pigs Previously Treated With Chemotherapy (2013) (10)
Passive transfer of tuberculin sensitivity from anergic mice (1984) (10)
Passive transfer of acquired resistance to Listeria monocytogenes infection is independent of mononuclear cell granuloma formation (1987) (9)
Identification of altered integrin α/β chain expression on T cells from old mice infected with Mycobacterium tuberculosis (2002) (9)
Tuberculosis in aged γδ T cell gene disrupted mice (2001) (9)
Efficacy of culture filtrate protein preparations from Indian isolates of M. tuberculosis to activate T cells derived from healthy donors. (2000) (8)
Aging and immunity to tuberculosis: prolonged survival of old mice infected with Mycobacterium tuberculosis by adoptive immunization with memory-immune T lymphocytes. (1989) (8)
Processing and presentation of mycobacterial antigens: implications for the development of a new improved vaccine for tuberculosis control. (1991) (8)
Infection with Mycobacterium kansasii and efficacy of vaccination against tuberculosis. (1983) (8)
Tuberculosis Vaccines (2012) (8)
Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372. (2014) (8)
Changes in integrin/adhesion molecule expression, but not in the T-cell receptor repertoire, in old mice infected with tuberculosis 1 This work was supported by NIH grant AG-06946. 1 (1998) (8)
Proteomic approaches to antigen discovery. (2004) (8)
Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice (2008) (8)
Pulmonary Tuberculosis in the Guinea Pig (2010) (8)
Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape. (2013) (8)
BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis. (2020) (7)
Tuberculosis in aged gammadelta T cell gene disrupted mice. (2001) (7)
Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission (2018) (7)
Influence of increased age on the development of herpes stromal keratitis (2003) (7)
Identification of altered integrin alpha/beta chain expression on T cells from old mice infected with Mycobacterium tuberculosis. (2002) (7)
CD95 Expression in Aged Mice Infected with Tuberculosis (1998) (7)
The dynamics of infection following BCG and Mycobacterium tuberculosis challenge in T-cell-deficient mice. (1987) (7)
4 Specific Models: 4.1 Murine Model of Tuberculosis (1998) (6)
Recombinant Protein Mtb 72 F , Delivered as Naked DNA or of a Tuberculosis Polyprotein Vaccine , Protective Efficacy Induced by Components Differential Immune Responses and and (2004) (6)
Antibody levels to the type-specific glycopeptidolipid antigens of Mycobacterium avium in homosexual men: possible implications. (1992) (6)
Prospects for new vaccines against tuberculosis. (2002) (6)
Anergy in Experimental Mouse Models of Mycobacterial Infection (1988) (5)
TB vaccine development: after the flood. (1999) (5)
The molecular targets of T cells in acquired immunity to tuberculosis. (1991) (5)
Tuberculosis: recent progress in basic immunity and vaccine development. (2000) (5)
Activation marker expression on bovine peripheral blood γδ T cells during post-natal development and following vaccination with a commercial polyvalent viral vaccine (2003) (5)
Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis. (2011) (5)
Animal Models of Mycobacteria Infection (1999) (5)
Bacille Calmette–Guérin Vaccines (2015) (5)
Activation marker expression on bovine peripheral blood gammadelta T cells during post-natal development and following vaccination with a commercial polyvalent viral vaccine. (2003) (5)
Concanavalin A-induced alteration of surface marker expression on murine T cells. (1982) (4)
Identification of novel immunogenic Mycobacterium tuberculosis peptides that stimulate mononuclear cells from immune donors. (1999) (4)
Vaccination of guinea pigs with BCG&Dgr;BCG1419c transiently reduces hematogenous spread of M. tuberculosis to the spleen (2018) (4)
CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection. (2000) (4)
Cigarette Smoke Increases Susceptibility To Tuberculosis: An In Vivo And In Vitro Study (2010) (4)
Tuberculosis Vaccine Preclinical Screening and Development (2005) (3)
Prostaglandin synthetase inhibitors prevent the induction of con A-activated suppressor T cells (1980) (3)
An age-related loss of the isogeneic barrier to the successful passive cell transfer of antimicrobial immunity in mice (1988) (3)
35 – Tuberculosis vaccines (2013) (3)
Crystalloid inclusions in the cytoplasm of alveolar macrophages of the SwR/J mouse. A possible cause of susceptibility to mycobacterium tuberculosis? (2001) (3)
Future research in tuberculosis. (1987) (3)
Pillars Article: The Kinetics of Emergence and Loss of Mediator T Lymphocytes Acquired in Response to Infection with Mycobacterium Tuberculosis. J. Immunol. 1987. 138: 293-298. (2017) (2)
Exogenous Re-infection by Multiple Exposures to Mycobacterium tuberculosis Contributes to Subsequent Development of Active Tuberculosis (2005) (2)
Tuberculosis and the Tubercle Bacillus, Second Edition (2017) (2)
Immunopathology of Tuberculosis (2017) (2)
T cell receptor (β chain) transgenic mice have selective deficits in γδ T cell subpopulations (1994) (2)
Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161 (2011) (1)
Potential complications to TB vaccine testing in animal models. (2009) (1)
Inhibition of growth Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor (1994) (1)
A Toll-Like Receptor-2-Directed Fusion Protein Vaccine against Tuberculosis (2008) (1)
TB's terrible toll (2014) (1)
T cell receptor (beta chain) transgenic mice have selective deficits in gamma delta T cell subpopulations. (1994) (1)
Prospects for New Vaccines against (2002) (1)
Mice Expressing Human Interleukin-32 (IL-32) In The Lungs Are More Resistant To Mycobacterium Tuberculosis (2012) (1)
The 65kDa antigen of mycobacteria. (1987) (1)
Immunization of mice with Mycobacterium leprae/Mycobacterium bovis BCG admixtures: modulation of the acquired response to BCG. (1987) (1)
Strain differentiation among Indian clinical isolates of M. tuberculosis by RFLP analysis. (2000) (1)
Atypical Mycobacteria: Immunocompetence of Heavily Infected Mice (0)
Towards controlling mycobacterial infections. (1999) (0)
THE INTERLEUKIN 12/INTERFERON GAMMA TH1 CD4 T CELL PATHWAY IN RESISTANCE TO TUBERCULOSIS (1995) (0)
Mice Expressing Human Interleukin-32 (IL-32) In The Lungs Have Increased Lung Compliance And Are More Resistant To Mycobacterium Tuberculosis (2011) (0)
Cytokines in Immunity to Tuberculosis (2009) (0)
Endocytic trafficking and the mycobacterial vacuole - General discussion I (1998) (0)
M-CSF and GM-CSF influence naïve murine alveolar macrophage differentiation and function in vitro (2015) (0)
Early Diagnosis and Treatment of Opportunistic Mycobacterial Infections in HIV-Seropositive AIDS Patients (1989) (0)
Mycobacterium tuberculosis Challenged with Granulomatous Lesions of Immune Mice Enhanced Macrophage Activity in (2006) (0)
Control of Infection Protective Antigen Associated with the Early Gene Encoding a Mycobacterium tuberculosis T Cell Expression Cloning of a (2000) (0)
Capacity ofMycobacterium aviumIsolates ToGrowWellor Poorly inMurine Macrophages Resides inTheir Ability To Induce Secretion ofTumorNecrosis Factor (1992) (0)
Structural BasisofCapacity ofLipoarabinomannan ToInduce Secretion ofTumorNecrosis Factor (1992) (0)
NOTES Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis (2005) (0)
Contributors (2008) (0)
UNDERSTANDING MYCOBACTERIUM ABSCESSUS PULMONARY AND DISSEMINATED DISEASE Submitted by Emily L. Layer Department of Microbiology, Immunology, and Pathology In partial fulfillment of the requirements For the Degree of Master of Science (2017) (0)
Down-RegulationTH1 Response followed by Rapid Strain HN878 Induces a Potent tuberculosis Mycobacterium The Hypervirulent (2007) (0)
Similar Bactericidal Activity But Improved Sterilizing Activity For Moxifloxacin-Containing Regimens Over The Standard Regimen For Tuberculosis In Animal Models (2011) (0)
Thebalancebetweenprotectiveand pathogenicimmuneresponsesinthe TB-infectedlung (2015) (0)
Letter to the editor. (2014) (0)
the IL-12 p40 Subunit Is Present Responses to Mycobacterial Infection Only if Protective, Antigen-Specific Cellular Mice Lacking Bioactive IL-12 Can Generate (2002) (0)
Immunology of Tuberculosis (2016) (0)
Neutrophil-associated disruption of the granulomatous response in BCG-vaccinated mice exposed to environmental mycobacteria (2017) (0)
The US-Japan Cooperative Medical Science Program Tuberculosis and Leprosy Panel's 36th Annual Research Conference, New Orleans, Louisiana, USA, 15-17 July 2001. Abstracts. (2002) (0)
Phenotypic Deﬁnition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis (cid:1) (2010) (0)
Chronic Pulmonary Tuberculosis in In Vivo IL-10 Production Reactivates (2002) (0)
Homologated Aza Analogues of Arabinose as Antimycobacterial Agents. (1998) (0)
The Cellular Immune Response to Mycobacterium tuberculosis Infection in the Guinea Pig 1 (2007) (0)
Frank Miles Collins (2003) (0)
A Limited Antigen-Speciﬁc Cellular Response Is Sufﬁcient for the Early Control of Mycobacterium tuberculosis in the Lung but Is Insufﬁcient for Long-Term Survival (2004) (0)
Bacillus Calmette–Guérin: How Good Is It and Can We Improve on It? (2016) (0)
Bertholet Mycobacterium tuberculosis Against Multidrug-Resistant A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects (2010) (0)
During Murine Pulmonary Tuberculosis Dynamics of Macrophage Cell Populations (2003) (0)
ImmuneResponse toAtypical Mycobacteria: Immunocompetence of Heavily Infected MiceMeasured InVivoFails ToSubstantiate Immunosuppression (1984) (0)
Receptor-Associated Factor Family and Antiapoptotic Markers of the TNF Molecules Characteristic of Dendritic Cells Express Mycobacterium tuberculosis Granulomas of Mice Infected with Foamy Macrophages within Lung (2005) (0)
Genetic Control ofNatural Resistance toNontuberculous Mycobacterial Infections inMice (1986) (0)
Dissemination ofEnteric Mycobacterium aviumInfections in MiceRendered Immunodeficient byThymectomy andCD4 Depletion orbyPrior Infection withMurine (1992) (0)

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