Ikumi Tamai
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Computer Science
Ikumi Tamai's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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(Suggest an Edit or Addition)Ikumi Tamai's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2* (1998) (690)
- Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (2000) (623)
- Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter (1999) (533)
- Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1 (1997) (445)
- Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane (2003) (407)
- Transporter-mediated permeation of drugs across the blood-brain barrier. (2000) (353)
- Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human (2004) (338)
- Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. (1999) (326)
- ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS (2005) (315)
- Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. (2002) (315)
- Carrier-Mediated Intestinal Transport of Drugs (1996) (312)
- Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice* (2000) (310)
- P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. (1992) (288)
- Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. (1999) (275)
- SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria (2014) (262)
- Active Secretion of Drugs from the Small Intestinal Epithelium in Rats by P‐Glycoprotein Functioning as an Absorption Barrier (1996) (239)
- Functional Characterization of Human Organic Anion Transporting Polypeptide B (OATP-B) in Comparison with Liver-Specific OATP-C (2001) (220)
- Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). (2000) (202)
- Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. (1998) (198)
- Extra-Renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2 (2012) (182)
- Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. (2001) (180)
- In Vivo and in Vitro Blood–Brain Barrier Transport of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (1994) (179)
- Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. (1995) (174)
- Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency. (1999) (173)
- Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepT1. (1999) (172)
- Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. (1991) (167)
- PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS (2006) (167)
- Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes (1988) (161)
- Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. (1990) (159)
- Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. (1993) (159)
- Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. (1996) (155)
- Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. (2001) (151)
- The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans (2011) (149)
- Functional relevance of carnitine transporter OCTN2 to brain distribution of l‐carnitine and acetyl‐l‐carnitine across the blood–brain barrier (2001) (148)
- Oral drug delivery utilizing intestinal OATP transporters. (2012) (146)
- p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. (2000) (144)
- In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. (1994) (144)
- Putative Transport Mechanism and Intracellular Fate of Trans-1-Amino-3-18F-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer (2011) (127)
- Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein. (1990) (122)
- Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21). (2013) (122)
- Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons (2011) (122)
- Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. (2004) (119)
- Identification of influx transporter for the quinolone antibacterial agent levofloxacin. (2007) (118)
- In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier. (1995) (115)
- Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat (2010) (115)
- cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. (1995) (114)
- H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. (1987) (111)
- Immunohistochemical and Functional Characterization of pH‐dependent Intestinal Absorption of Weak Organic Acids by the Monocarboxylic Acid Transporter MCT1 (1999) (111)
- Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-Glycoprotein (2008) (111)
- Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy. (2011) (111)
- Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. (2004) (109)
- Drug delivery through the blood-brain barrier (1996) (109)
- Effect of γ‐butyrobetaine on fatty liver in juvenile visceral steatosis mice (2001) (108)
- Blood-brain barrier function of P-glycoprotein (1997) (107)
- Transcellular Transport of Benzole Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport Mechanism (2004) (106)
- pH‐Dependent and Carrier‐mediated Transport of Salicylic Acid Across Caco‐2 Cells (1994) (103)
- Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. (2012) (103)
- Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. (1993) (102)
- Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies (2004) (101)
- Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. (1998) (99)
- Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. (2010) (99)
- INVOLVEMENT OF URIC ACID TRANSPORTER IN INCREASED RENAL CLEARANCE OF THE XANTHINE OXIDASE INHIBITOR OXYPURINOL INDUCED BY A URICOSURIC AGENT, BENZBROMARONE (2005) (98)
- Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice. (1999) (98)
- P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice (1999) (95)
- Concentration-Dependent Mode of Interaction of Angiotensin II Receptor Blockers with Uric Acid Transporter (2007) (93)
- The Predominant Contribution of Oligopeptide Transporter PepT1 to Intestinal Absorption of β‐Lactam Antibiotics in the Rat Small Intestine (1997) (93)
- Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse (2006) (92)
- Cancer cell‐targeted drug delivery utilizing oligopeptide transport activity (2000) (86)
- Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer (2019) (85)
- Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier. (1995) (85)
- Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1. (1998) (84)
- Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. (2000) (84)
- Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood‐brain barrier (2001) (81)
- PepT1 mRNA Expression Is Induced by Starvation and Its Level Correlates with Absorptive Transport of Cefadroxil Longitudinally in the Rat Intestine (2002) (81)
- Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors. (2010) (80)
- Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp) (2009) (80)
- Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier. (1997) (79)
- Involvement of Uric Acid Transporters in Alteration of Serum Uric Acid Level by Angiotensin II Receptor Blockers (2008) (79)
- Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide (2010) (78)
- Involvement of Multidrug Resistance-Associated Protein 2 in Intestinal Secretion of Grepafloxacin in Rats (2002) (76)
- Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes (2008) (74)
- Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. (2010) (67)
- Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. (2010) (67)
- Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein (2002) (67)
- Acetyl‐L‐carnitine permeability across the blood–brain barrier and involvement of carnitine transporter OCTN2 (2003) (66)
- Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080. (1997) (66)
- Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics (2008) (65)
- Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β‐lactam antibiotics (1996) (63)
- Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice. (1999) (62)
- Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters. (1997) (62)
- Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics. (2008) (62)
- Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. (2011) (61)
- Interaction of Drug or Food with Drug Transporters in Intestine and Liver. (2015) (61)
- Suppression of Cell Proliferation by Inhibition of Estrone-3-Sulfate Transporter in Estrogen-Dependent Breast Cancer Cells (2005) (61)
- Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport. (1990) (60)
- Carrier-mediated approaches for oral drug delivery (1996) (59)
- Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. (2013) (59)
- Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. (2011) (57)
- Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells. (2018) (57)
- Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P‐glycoprotein (2001) (57)
- Insoluble Powder Formulation as an Effective Nasal Drug Delivery System (2002) (57)
- Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. (2012) (56)
- Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites. (2012) (56)
- Stereospecific Absorption and Degradation of Cephalexin (1988) (56)
- Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane (1995) (55)
- Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver (2010) (55)
- Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency (2000) (55)
- Improved nasal bioavailability of elcatonin by insoluble powder formulation. (2001) (55)
- Total syntheses of (-)- and (+)-goniomitine. (2011) (54)
- Influence of Drugs and Nutrients on Transporter Gene Expression Levels in Caco-2 and LS180 Intestinal Epithelial Cell Lines (2003) (54)
- Oseltamivir (Tamiflu) Is a Substrate of Peptide Transporter 1 (2009) (53)
- Nicotinic Acid Transport Mediated by pH‐dependent Anion Antiporter and Proton Cotransporter in Rabbit Intestinal Brush‐border Membrane (1996) (53)
- Involvement of Estrone-3-Sulfate Transporters in Proliferation of Hormone-Dependent Breast Cancer Cells (2004) (51)
- β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane (1987) (50)
- Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. (2013) (50)
- Molecular and Physiological Evidence for Multifunctionality of Carnitine / Organic Cation Transporter OCTN 2 (2001) (50)
- Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug. (2003) (50)
- Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). (2008) (50)
- 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. (2021) (49)
- OATP transporter-mediated drug absorption and interaction. (2013) (49)
- Role of polyamines derived from arginine in differentiation and proliferation of human blood cells. (2006) (48)
- TRANSPORT OF THE DOPAMINE D2 AGONIST PRAMIPEXOLE BY RAT ORGANIC CATION TRANSPORTERS OCT1 AND OCT2 IN KIDNEY (2005) (48)
- Intestinal brush‐border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits (1993) (48)
- pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H(+)-cotransport mechanism versus pH-partition hypothesis. (1990) (47)
- In vivo evidence for carrier-mediated uptake of beta-lactam antibiotics through organic anion transport systems in rat kidney and liver. (1990) (46)
- Kinetic analyses of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. (2013) (46)
- L-arginine import via cationic amino acid transporter CAT1 is essential for both differentiation and proliferation of erythrocytes. (2006) (46)
- Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1 (2014) (45)
- Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency. (1998) (45)
- Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits. (1988) (44)
- Contribution of organic anion transporting polypeptide OATP‐C to hepatic elimination of the opioid pentapeptide analogue [d‐Ala 2 , d‐Leu5]‐enkephalin (2003) (44)
- Long-Lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-Mediated Drug Absorption (2013) (44)
- Loss of wild‐type carrier‐mediated L‐carnitine transport activity in hepatocytes of juvenile visceral steatosis mice (1999) (44)
- Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells (2005) (44)
- Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier. (1999) (43)
- Intestinal Brush‐border Membrane Transport of Monocarboxylic Acids Mediated by Proton‐coupled Transport and Anion Antiport Mechanisms (1997) (43)
- Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. (2007) (43)
- Saturable uptake of cefixime, a new oral cephalosporin without an α‐amino group, by the rat intestine (1987) (42)
- EFFECT OF P-GLYCOPROTEIN ON INTESTINAL ABSORPTION AND BRAIN PENETRATION OF ANTIALLERGIC AGENT BEPOTASTINE BESILATE (2006) (42)
- Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha. (2008) (42)
- Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake. (2010) (42)
- Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer. (2003) (42)
- Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa. (2007) (41)
- Faropenem Transport across the Renal Epithelial Luminal Membrane via Inorganic Phosphate Transporter Npt1 (2000) (41)
- Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc- in immortalized rat brain endothelial cells. (2005) (41)
- Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5 (2012) (41)
- Caco‐2 cells – expression, regulation and function of drug transporters compared with human jejunal tissue (2017) (41)
- Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate. (2013) (41)
- Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent. (1998) (40)
- Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter. (2002) (39)
- Mechanism of the Regulation of Organic Cation/Carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines (2007) (39)
- Functional expression of transporter for beta-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines. (1995) (39)
- Blood-Brain Barrier Transport of H1-Antagonist Ebastine and its Metabolite Carebastine (2000) (39)
- Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation. (2004) (38)
- Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes. (2002) (38)
- Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 Cells (1996) (38)
- Predominant Contribution of Rat Organic Anion Transporting Polypeptide-2 (Oatp2) to Hepatic Uptake of β-Lactam Antibiotics (2008) (37)
- Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1 (2018) (37)
- Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride (2016) (36)
- Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer (2010) (36)
- OCTN2-mediated transport of carnitine in isolated Sertoli cells. (2005) (36)
- Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A. (2006) (36)
- Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells. (1998) (35)
- Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans (2011) (35)
- Accumulation of Trans-1-Amino-3-[18F]Fluorocyclobutanecarboxylic Acid in Prostate Cancer due to Androgen-Induced Expression of Amino Acid Transporters (2014) (34)
- Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells. (2006) (34)
- Transporter-mediated intestinal absorption of fexofenadine in rats. (2006) (33)
- Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. (2011) (33)
- Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis (2015) (32)
- Characterization of Hepatobiliary Transport Systems of a Novel α4β1/α4β7 Dual Antagonist, TR-14035 (2006) (32)
- Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers. (2011) (32)
- Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes (2011) (32)
- Involvement of Rat and Human Organic Anion Transporter 3 in the Renal Tubular Secretion of Topotecan [(S)-9-Dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride] (2007) (32)
- Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis. (2007) (32)
- Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells. (2003) (32)
- Sodium and Chloride Ion‐Dependent Transport of β‐Alanine Across the Blood‐Brain Barrier (1996) (31)
- Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells. (2018) (31)
- Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins (2008) (31)
- Secretory transport of p‐aminohippuric acid across intestinal epithelial cells in Caco‐2 cells and isolated intestinal tissue (2001) (31)
- Decreased Proliferation and Erythroid Differentiation of K562 Cells by siRNA-induced Depression of OCTN1 (SLC22A4) Transporter Gene (2007) (31)
- Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay! (2012) (30)
- OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion. (2015) (30)
- The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion. (2015) (30)
- Organic anion transporters. (1999) (30)
- Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes. (1994) (30)
- Structural characterization of substrates for the anion exchange transporter in Caco-2 cells. (1999) (30)
- Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans. (1992) (30)
- Membrane potential-dependent and carrier-mediated transport of cefpiramide, a cephalosporin antibiotic, in canalicular rat liver plasma membrane vesicles. (1990) (29)
- Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats (2007) (29)
- Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins (2017) (29)
- Carrier-mediated transport of cefixime, a new cephalosporin antibiotic, via an organic anion transport system in the rat renal brush-border membrane. (1988) (29)
- Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers (2014) (29)
- Decreased Biosynthesis of Lung Surfactant Constituent Phosphatidylcholine Due to Inhibition of Choline Transporter by Gefitinib in Lung Alveolar Cells (2008) (28)
- Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Evidence for a carrier-mediated transport system. (1986) (28)
- Mathematical modeling of the in vitro hepatic disposition of mycophenolic acid and its glucuronide in sandwich-cultured human hepatocytes. (2014) (28)
- Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever (2018) (28)
- Regulation of drug transporters by the farnesoid X receptor in mice. (2004) (28)
- Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys. (2015) (27)
- Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. (2004) (27)
- Carnitine Content and Expression of Mitochondrial β-Oxidation Enzymes in Placentas of Wild-Type (OCTN2+/+) and OCTN2 Null (OCTN2−/−) Mice (2004) (26)
- Organic anion transporter OAT1 is involved in renal handling of citrulline. (2009) (26)
- Cancer cells uptake porphyrins via heme carrier protein 1 (2013) (26)
- Evidence for a carrier-mediated transport system in the small intestine available for FK089, a new cephalosporin antibiotic without an amino group. (1986) (26)
- Sodium- and chloride-dependent transport of taurine at the blood-brain barrier. (1996) (25)
- The α1-adrenergic photoaffinity probe [125I]arylazidoprazosin binds to a specific peptide of P-glycoprotein in multidrug-resistant cells (1990) (25)
- Transport of organic cations across the blood-testis barrier. (2007) (25)
- Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake. (1986) (25)
- Characteristics of L‐Carnitine Transport in Cultured Human Hepatoma HLF Cells (1999) (25)
- Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane. (1990) (24)
- Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles. (1991) (24)
- Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis. (1998) (23)
- Functional cooperation of SMCTs and URAT1 for renal reabsorption transport of urate. (2013) (23)
- Mechanism of Absorption of the Dipeptide α-Methyldopa-phe in Intestinal Brush-Border Membrane Vesicles (1990) (23)
- Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): roles in carnitine recognition. (2004) (23)
- N-(p-azido-3-[125I]iodophenethyl)spiperone binds to specific regions of P-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells. (1994) (23)
- A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer (2017) (23)
- Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats. (2009) (23)
- ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket (2020) (22)
- Peptide derivation of poorly absorbable drug allows intestinal absorption via peptide transporter. (2009) (22)
- A carrier‐mediated transport system for benzylpenicillin in isolated hepatocytes (1985) (22)
- Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. (2005) (22)
- Transporter-mediated renal handling of nafamostat mesilate. (2004) (22)
- Blood‐brain‐barrier Transport of Lipid Microspheres Containing Clinprost, a Prostaglandin I2 Analogue (1996) (22)
- Carrier-mediated lung distribution of HSR-903, a new quinolone antibacterial agent. (1999) (21)
- A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS. (2013) (21)
- Transport characteristics of L‐citrulline in renal apical membrane of proximal tubular cells (2009) (21)
- Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers. (2014) (21)
- Transport mechanism of cephalexin in isolated hepatocytes. (1987) (20)
- Possible Role of Anion Exchanger AE2 as the Intestinal Monocarboxylic Acid/Anion Antiporter (1998) (20)
- Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3. (2016) (20)
- Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier. (2006) (20)
- Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid). (2009) (20)
- Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2. (2017) (20)
- Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer. (2012) (19)
- Local Drug–Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart (2016) (19)
- In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice. (2013) (19)
- Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan. (2014) (19)
- Characterization of Human OATP2B1 (SLCO2B1) Gene Promoter Regulation (2006) (19)
- Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue. (2016) (18)
- Hydrolysis of prednisolone succinate by esterase in rabbit ocular tissue. (1987) (17)
- P‐gp activity and inhibition in the different regions of human intestine ex vivo (2017) (17)
- Identification of the Catechin Uptake Transporter Responsible for Intestinal Absorption of Epigallocatechin Gallate in Mice (2019) (17)
- Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. (2011) (17)
- Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy. (1990) (17)
- Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. (2006) (17)
- Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells. (2015) (17)
- Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy. (2015) (16)
- Evidence for the existence of a common transport system of beta-lactam antibiotics in isolated rat hepatocytes. (1985) (16)
- Brain‐to‐blood active transport of β‐alanine across the blood–brain barrier (1997) (16)
- Muscle distribution of antimicrobial agents after a single intravenous administration to rats. (2002) (16)
- Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. (2008) (16)
- Age-related change in tissue-to-plasma partition coefficient of cefazolin for noneliminating organs in the rat. (1989) (16)
- Molecular localization and characterization of multiple binding sites of organic anion transporting polypeptide 2B1 (OATP2B1) as the mechanism for substrate and modulator dependent drug–drug interaction (2016) (15)
- Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes (2016) (15)
- Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions (2017) (15)
- Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress. (2016) (14)
- Involvement of Organic Anion Transporting Polypeptide 1a5 (Oatp1a5) in the Intestinal Absorption of Endothelin Receptor Antagonist in Rats (2008) (14)
- Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter–Enzyme Interplay (2018) (14)
- Role of Anion Exchange Transporter PAT1 (SLC26A6) in Intestinal Absorption of Organic Anions (2004) (14)
- MDR1 is Related to Intestinal Epithelial Injury Induced by Acetylsalicylic Acid (2013) (14)
- Application of Muscle Microdialysis to Evaluate the Concentrations of the Fluoroquinolones Pazufloxacin and Ofloxacin in the Tissue Interstitial Fluids of Rats (1997) (14)
- Evaluation of Hepatic Disposition of Paroxetine Using Sandwich-Cultured Rat and Human Hepatocytes (2013) (14)
- Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake. (2010) (14)
- [Molecular characterization of intestinal absorption of drugs by carrier-mediated transport mechanisms]. (1997) (13)
- Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2. (2015) (13)
- Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1. (2017) (13)
- Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells. (2015) (13)
- Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites. (2012) (13)
- Introduction to the Blood–Brain Barrier: Blood–brain barrier transport of drugs (1998) (12)
- Different Efflux Transporter Affinity and Metabolism of 99mTc-2-Methoxyisobutylisonitrile and 99mTc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer (2018) (12)
- Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. (2002) (12)
- In‐vitro evidence of enhanced breast cancer resistance protein‐mediated intestinal urate secretion by uremic toxins in Caco‐2 cells (2015) (12)
- Design and Synthesis of Peptides Passing through the Blood-Brain Barrier (1998) (11)
- Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats (2010) (11)
- Synthesis of [¹¹C]uric acid, using [¹¹C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout. (2012) (11)
- Characterization of nucleobase transport by mouse Sertoli cell line TM4. (2009) (11)
- Delivery of Peptide Drugs to the Brain by Adenovirus-Mediated Heterologous Expression of Human Oligopeptide Transporter at the Blood-Brain Barrier (2003) (11)
- Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide. (2015) (11)
- Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system. (1991) (11)
- Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice. (2001) (10)
- Kinetic analysis and characterization of the bacterial regrowth after treatment of Escherichia coli with beta-lactam antibiotics. (1984) (10)
- Physicochemical Properties of Calcium Polycarbophil, a Water‐absorbing Polymer (1996) (10)
- Application of Fractal Kinetics for Carrier-Mediated Transport of Drugs Across Intestinal Epithelial Membrane (1998) (10)
- Regulation of testis-specific carnitine transporter (octn3) gene by proximal cis-acting elements Sp1 in mice. (2005) (10)
- Expression of the Na+ dependent uridine transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes. (1993) (10)
- Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction (2020) (10)
- Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1. (2002) (9)
- Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transports of anticancer trifluridine (2018) (9)
- [Tissue distribution of the multidrug-resistance gene product P-glycoprotein and its physiological function]. (1997) (9)
- Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane. (2000) (9)
- Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver. (2008) (8)
- INTESTINAL UPTAKE OF β-LACTAM ANTIBIOTICS WITHOUT AN α-AMINO GROUP AND ITS RELATIONSHIP TO DIPEPTIDE TRANSPORT (1987) (8)
- A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors. (2016) (8)
- Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides. (2007) (8)
- Usefulness of kidney slices for functional analysis of apical reabsorptive transporters (2017) (8)
- Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells (2018) (8)
- Effect of endogenous multidrug resistance 1 and P‐glycoprotein expression on anticancer drug resistance in colon cancer cell lines (2018) (8)
- Cyclophosphamide‐induced hemorrhagic cystitis in young patients with solid tumors: A single institution study (2018) (8)
- Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia (2019) (8)
- Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo (2021) (7)
- Chapter 6:Drug Transporters in the Lung: Expression and Potential Impact on Pulmonary Drug Disposition (2016) (7)
- Decalcification of calcium polycarbophil in rats. (1997) (7)
- Hepatic Uptake of Octreotide, a Long-Acting Somatostatin Analogue, via a Bile Acid Transport System (2004) (7)
- Peritoneal transport of beta-lactam antibiotics: effects of plasma protein binding and the interspecies relationship. (1988) (7)
- Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban. (2017) (7)
- Adsorptive-Mediated Transcytosis of a Synthetic Basic Peptide, 001-C8 in Caco-2 Cells (1998) (7)
- High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans. (2015) (7)
- Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9. (2020) (7)
- Experimental Evidence for Resecretion of PGE2 across Rat Alveolar Epithelium by OATP2A1/SLCO2A1-Mediated Transcellular Transport (2018) (7)
- In situ and in vitro evidence for stereoselective and carrier-mediated transport of monocarboxylic acids across intestinal epithelial tissue. (2000) (6)
- Na+ and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane. (1989) (6)
- Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers (2019) (6)
- Brain-to-blood active transport of beta-alanine across the blood-brain barrier. (1997) (6)
- Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells. (2019) (6)
- Improved intestinal membrane permeability of hexose-quinoline derivatives via the hexose transporter, SGLT1. (2008) (6)
- Kinetics of benzylpenicillin metabolism in isolated rat hepatocytes. (1987) (6)
- Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2. (2011) (6)
- Drug treatment for elderly patients. (1987) (6)
- Identification of Triterpene Acids in Poria cocos Extract as Bile Acid Uptake Transporter Inhibitors (2021) (5)
- Kinetics of peritoneal drug transport in rats: an application of the pore theory of transcapillary exchange. (1988) (5)
- Mathematical modeling analysis of hepatic uric acid disposition using human sandwich-cultured hepatocytes. (2020) (5)
- How Does Whisky Lower Serum Urate Level? (2014) (5)
- Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation (2021) (5)
- Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions (2017) (5)
- Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24. (2020) (5)
- Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats. (2019) (5)
- Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation. (2020) (5)
- Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na⁺/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake. (2012) (5)
- Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples (2020) (5)
- More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes. (2014) (5)
- Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines (2018) (5)
- Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane. (1987) (4)
- In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans (2018) (4)
- FUNCTIONAL EXPRESSION OF CARNITINE / ORGANIC CATION TRANSPORTER OCTN 1 ( SLC 22 A 4 ) IN MOUSE SMALL INTESTINE (2009) (4)
- MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion–Transporting Peptide 2B1/SLCO2B1 in Caco-2 Cells (2021) (4)
- Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700. (2006) (4)
- The alpha 1-adrenergic photoaffinity probe [125I]arylazidoprazosin binds to a specific peptide of P-glycoprotein in multidrug-resistant cells. (1990) (4)
- [The inhibitors of the apical sodium-dependent bile acid transporter (ASBT) as promising drugs]. (2020) (4)
- Hepatic uptake of -butyrobetaine, a precursor of carnitine biosynthesis, in rats (2009) (4)
- Changes of differentiation and proliferation in k562 cells with various levels of knockdown of cationic amino acid transporter 1. (2008) (4)
- Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect? (2017) (3)
- Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics: Contribution of Transporters to Metformin Absorption. (2022) (3)
- [131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma. (2020) (3)
- Novel LC-MS/MS Method for Simultaneous Quantification of KW-7158, a New Drug Candidate for Urinary Incontinence and Bladder Hyperactivity, and its Metabolites in Rat Plasma: A Pharmacokinetic Study in Male and Female Rats (2012) (3)
- Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts. (2017) (3)
- The Effect of Polycarbophil on Water Transport in Rat Intestine (1996) (3)
- Association of miR-145 With Statin-Induced Skeletal Muscle Toxicity in Human Rhabdomyosarcoma RD Cells. (2017) (3)
- TRANSPORT OF THE DOPAMINE D 2 AGONIST PRAMIPEXOLE BY RAT ORGANIC CATION TRANSPORTERS OCT 1 AND OCT 2 IN KIDNEY (2005) (3)
- Binding mechanism and structure-binding relationship of β-lactam amtibiotics to humans antibiotics to human serum albumin (1986) (3)
- Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction. (2009) (3)
- Involvement of uric acid transporter URAT1 in increased renal clearance of xanthine oxidase inhibitor oxypurinol by uricosuric agents (2005) (2)
- A novel fluorescence-based method to evaluate ileal apical sodium-dependent bile acid transporter ASBT. (2020) (2)
- Corrigendum to "Kinetic analyses of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2" (Nucl. Med. Biol. 2013;40:670-675). (2015) (2)
- Quantitation of talinolol in rat plasma by LC-MS-MS. (2010) (2)
- Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells. (2020) (2)
- [Transporter-mediated drug interaction]. (2014) (2)
- Degradation kinetics of (+/-)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HY-770) and structure-stability relationship among its analogues in aqueous solution. (1989) (2)
- Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System. (2018) (2)
- Quantification of Prostaglandin E2 Concentration in Interstitial Fluid from the Hypothalamic Region of Free-moving Mice. (2019) (2)
- Inhibitors of the Apical Sodium-Dependent Bile Acid Transporter (ASBT) as Promising Drugs (2021) (1)
- Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme (2021) (1)
- Analysis of Intestinal Transporters (2013) (1)
- Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening (2022) (1)
- How should we handle decreased efficacy caused by DDI on transporters for drug absorption and target-tissue distribution, but not associated with toxicity? (2013) (1)
- MULTIOLICITY OF FUNCTIONAL CHARACTERIZATION AND TISSUE DISTRIBUTION OF OCTN-TRANSPORTER FAMILY (1999) (1)
- Influence of preparation method on polynucleotide conformation and pharmacological activity of lipoplex. (2011) (1)
- Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid. (2021) (1)
- BINDING MECHANISM AND STRUCTURE-BINDING RELATIONSHIP OF β-LACTAM ANTIBIOTICS TO HUMAN SERUM ALBUMIN (1986) (1)
- Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption (2021) (1)
- Gordon L. Amidon: Very Sustained Drug Absorption. (2015) (1)
- Drug Transcellular Transport Assay Using a High Porosity Honeycomb Film. (2021) (1)
- Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol (2019) (1)
- Psychosocial Determinants of Risky Sexual Behaviour by Gender in Spain (2013) (1)
- [Improvement of intestinal absorption of drugs by activating peptide transporter PEPT1 by acidic polymers]. (2005) (1)
- Foreword. (2018) (1)
- Development of screening system for oral drug delivery of .BETA.-lactam antibiotics using a clone of intestinal oligopeptide transporter. (1996) (1)
- TRANSPORT OF β-LACTAM ANTIBIOTICS VIA THE DIPEPTIDE CARRIER SYSTEM ACROSS INTESTINAL BRUSH-BORDER MEMBRANE (1987) (1)
- Structural Requirements of Substrates for Stereoselective Monocarboxylate Transport in Caco‐2 Cells (2000) (1)
- Regulatory Effect of Fruit‐derived Nanoparticle on Intestinal Transporters (2018) (0)
- Identification of the uptake transporter responsible for distribution of acotiamide into stomach tissue. (2020) (0)
- Mouse placental distribution of enzymes and transporter modulating PGE2 level (2015) (0)
- Adjusting serum urate level by affecting membrane transporters involved in the disposition of urate (2013) (0)
- Angiotensin II Receptor Blockers Induce Alteration of Serum Uric Acid Level via Renal Uric Acid Transporters. A Review of the Authors' Current Research (2009) (0)
- 464 Liver delivery of adefovir by heterologous expression of organic anion transporter OAT1 (2003) (0)
- Clinical Stabilization in Parkinson´s Disease: The Multi-Target Treatment Description and Results (2013) (0)
- For Further Contribution of DMPK to Drug Discovery, Development and Pharmacotherapy (2010) (0)
- Molecular and Functional Characterization of Carnitine/Organic Cation Transporter OCTN Family in Human and Mouse. (2000) (0)
- Repeat Paediatric Dental General Anaesthetics: A Study of Two Regions (2013) (0)
- Intracanal Antimicrobial against Enterococcus Faecalis (2013) (0)
- GENETIC POLYMORPHISM OF DRUG TRANSPORTERS (2000) (0)
- A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells (2023) (0)
- Successful Pregnancy Outcome and Surgical Approach in Women with Repaired BladderExstrophy or Cloacal Exstrophy – Experience from a Paediatric and Adolescent Gynaecology Service in a Quarternary Australian Hospital. (2013) (0)
- DMD # 19125-1-Involvement of multidrug resistance-associated protein 2 ( Abcc 2 ) in molecular weight-dependent biliary excretion of ß-lactam antibiotics (2008) (0)
- New aspects of transporter research: future may exist "beyond the transport". Preface. (2008) (0)
- DMD049817 735..743 (2013) (0)
- MOLECULAR AND FUNCTIONAL IDENTIFICATION OF NOVEL HUMAN ORGANIC CATION TRANSPORTER FAMILY, OCTN1 AND OCTN2 (1998) (0)
- DIFFERENTIAL EXPRESSION OF ORGANIC CATION TRANSPORTERS IN RAT DORSAL ROOT GANGLIA (2010) (0)
- Su1802 – Slco2A1 Deficiency Exacerbates Experimental Colitis Via Inflammasome Activation in Macrophages (2019) (0)
- Transport mechanism of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (18F-FACBC) PET radiotracer in human prostate cancer (2013) (0)
- TISSUE AND INTRA-CELLULAR DISTRIBUTION OF INTESTINAL OLIGOPEPTIDE TRANSPORTER AND ITS FUNCTIONAL CHARACTERIZATION (1995) (0)
- CARRIER-MEDIATED TRANSPORT MECHANISM OF β-LACTAM ANTIBIOTICS IN ISOLATED HEPATOCYTES (1984) (0)
- Pharmacokinetic evaluation of dehydroepiandrosterone sulfate (DHEAS) as an endogenous probe to predict drug-drug interaction on hepatic OATP in rats (2017) (0)
- Drug Delivery by Utilizing Oligopeptide Transporter. (1999) (0)
- Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1 (2018) (0)
- Usefulness of kidney slices for functional analysis of apical reabsorptive transporters (2017) (0)
- PERITONEAL MEMBRANE TRANSPORT OF DRUGS (1987) (0)
- Biological Distribution after Oral Administration of Radioiodine-Labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs, and/or MRPs (2023) (0)
- Wax Tissue Compensator for Head and Neck Radiotherapy - Fabrication andDosimetric Evaluation (2013) (0)
- Nonlinear absorption caused by secretiory mechanism in small intestine (1996) (0)
- Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins (2017) (0)
- Involvement of functional groups on the surface of carboxyl group-terminated PAMAM dendrimers bearing arbutin in inhibition of SGLT 1-mediated D-glucose uptake (2013) (0)
- Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1 (2014) (0)
- Diagnostic Accuracy of Saline-Contrast Sonohysterography Guided Biopsyversus Office Biopsy in Endometrial Pathology: an Interventional Study (2013) (0)
- Transporter-targeted oral drug delivery (2010) (0)
- Design and Synthesis of Peptides Passing Through the Blood-Brain Barrier. (1998) (0)
- Comparative evaluation of dehydroepiandrosterone sulfate (DHEAS) potential to predict hepatic OATP transporter-based drug-drug interactions (2016) (0)
- EFFECT OF UV-IRRADIATION ON DERMAL PHARMACOKINETICS OF KETOPROFEN AND ITS PHOTOPRODUCTS IN GUINEA PIGS (2006) (0)
- Transport of different HMG-CoA reductase inhibitors across the blood-brain and intestinal epithelial barriers (1994) (0)
- Pharmacological relevance of intestinal drug transporters (2013) (0)
- CD38 activation by monosodium urate crystals contributes to inflammatory responses in human and murine macrophages. (2021) (0)
- Expression and function of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation (2006) (0)
- Different Efflux Transporter Affinity and Metabolism of 99mTc-2-Methoxyisobutylisonitrile and 99mTc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer (2018) (0)
- SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl-Ketone Warhead (2022) (0)
- Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals (2012) (0)
- A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer (2017) (0)
- Expression and function of prostaglandin transporter in the murine placenta (2016) (0)
- Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer (2019) (0)
- Molecular Mechanisms of Intestinal Absorptive and Secretory Transports of Drugs (1999) (0)
- Inhibition of the Hepatic Uptake of 99mTc-Tetrofosmin Using an Organic Cation Transporter Blocker (2021) (0)
- The Cox-2 Inhibitor Meloxicam Ameliorates Neuroinflammation and DepressiveBehavior in Adult Mice after Splenectomy (2013) (0)
- Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα (2023) (0)
- Identification of anion transporters shouldering renal and hepatic excretion of drugs. (1998) (0)
- Influence of Preparation Method on Polynucleotide Conformation and Pharmacological Activity of Lipoplex Authors (2010) (0)
- Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells. (1998) (0)
- Oral drug delivery system targeting intestinal transporters (2018) (0)
- Author Correction: Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol (2019) (0)
- Oral Presentations DIFFERENTIAL TRANSPORTER-MEDIATED INTERACTION OF FRUIT JUICE WITH PRAVASTATIN AND PITAVASTATIN IN RATS (2010) (0)
- TRANSCELLULAR TRANSPORT MECHANISM OF β-LACTAM ANTIBIOTICS AND ITS INTERORGAN RELATIONSHIP AMONG SMALL INTESTINE, KIDNEY AND LIVER (1989) (0)
- 110110_Text for DMD_Revised Ipra&OCT (clear) (2010) (0)
- WITHDRAWN: Distribution of enzymes and transporter regulating prostaglandin E2signaling in the mouse placenta throughout gestation (2015) (0)
- Involvement of nuclear receptors peroxisome proliferator -activated receptor alpha (PPAR alpha) and pregnane X receptor (PXR) in expressional regulation of organic cation/carnitine transporter OCTN2 (SLC22A5) (2006) (0)
- A Photographic Assessment of Fluorosis in 10-12 Year Old Children Living inThree Areas of New South Wales Australia (2013) (0)
- Unappreciated role of prostaglandin transporters in pulmonary fibrosis (2017) (0)
- Roles and Application of Extracellular Vesicles Occurring Endogenously and Naturally (2023) (0)
- A MOLECULAR MECHANISM OF HEPATIC UPTAKE OF Γ-BUTYROBETAINE, A PRECURSOR OF CARNITINE BIOSYNTHESIS (2009) (0)
- Stability of Ursodeoxycholic Acid Tablets in One-Dose Packaging (0)
- Preparation of Quinoline Hexose Analogues as Novel Chloroquine‐Resistant Malaria Treatments. Part 1. Synthesis of 4‐Hydroxyquinoline‐β‐glucosides. (2007) (0)
- S1-3 Transporters at the Blood-Brain Barrier and Toxlcity in CNS(Proceedings of the 27th Annual Meeting) (2000) (0)
- Title Pharmacological and pathophysiological roles of carnitine / organic cationtransporters ( OCTNs : SLC 22 A 4 , SLC 22 A 5 and Slc 22 a 21 ) Author ( s (2017) (0)
- TRANSCRIPTIONAL REGULATION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (2004) (0)
- Specific binding of uric acid to NDFIP1 associates with hyperuricemia-induced liver fat accumulation (2022) (0)
- TISSUE DISTRIBUTION AND FUNCTIONAL CHARACTERIZATION OF ORGANIC CATION/CARNITINE TRANSPORTER OCTN1 (2001) (0)
- Effect of polycarbophil on the absorption of nutrients. (1996) (0)
- Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT. (2023) (0)
- Evaluation of Platinum Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue Slices by Using Gas-Permeable Plates. (2022) (0)
- Transporters as Molecular Targets for Drug Delivery and Disposition (2004) (0)
- Trans-inhibitory effect of dotinurad, a uricosuric agent on uric acid reabsorptive transporter URAT1 (2022) (0)
- Abstract 4391: OCTN1- and OCTN2-mediated uptake of oxaliplatin in rat dorsal root ganglion neurons and HEK293 cells over-expressing OCTN1 or OCTN2 (2011) (0)
- MOLECULAR CHARACTERIZATION OF INTESTINAL ABSORPTION FOR MONOCARBOXYLIC ACIDS MEDIATED BY PROTON-COUPLED TRANSPORTER (1995) (0)
- Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model (2023) (0)
- Tissue Selective Drug Derivery Utilizing Oligopeptide Transporter (1997) (0)
- Study on Peptide Transport across Tissue Cell Menbrane by Adsorptive-Mediated Transcytosis (1996) (0)
- Confirmation of Carrier-Mediated Intestinal Transport of β-Lactam Antiboitics by Using Gene Expression in Xenopus laevis Oocytes (1993) (0)
- DIFFERENTIAL EXPRESSION OF TRANSPORTERS IN THE INTESTINE AND ITS APPLICATION TO REGULATION OF THE DRUG ABSORPTION (2001) (0)
- Oral Drug Delivery by Activation of Peptide Transporter PEPT1 (2011) (0)
- Management of Maxillary Flabby Tissue & Highly Resorbed MandibularRidges (2013) (0)
- Potential of prostaglandin transporter OATP2A1/SLCO2A1 as a target of novel anti-inflammatory drug (2017) (0)
- Title Influence of preparation method on polynucleotide conformation andpharmacological activity of lipoplex (2017) (0)
- Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers (2014) (0)
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