Inge Grundke‐iqbal

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Inge Grundke‐iqbal

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Inge Grundke‐iqbal

Biology

#5731

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Neuroscience

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#692

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Philosophy
Biology

Inge Grundke‐iqbal's Degrees

PhD Neuroscience University of California, San Diego
Doctorate Medicine University of California, San Diego

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Inge Grundke‐iqbal's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. (1986) (3176)
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. (1986) (1628)
Tau pathology in Alzheimer disease and other tauopathies. (2005) (937)
Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments (2001) (870)
Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease (1989) (787)
Tau in Alzheimer disease and related tauopathies. (2010) (783)
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules (1996) (772)
Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology (1987) (705)
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation (2005) (692)
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. (1994) (671)
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. (1993) (650)
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. (2004) (642)
Mechanisms of tau-induced neurodegeneration (2009) (591)
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration (2007) (504)
Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain (1993) (503)
Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain (1995) (446)
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes (2011) (428)
Brain iron and ferritin in Parkinson's and Alzheimer's diseases (1990) (428)
Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes (1999) (428)
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques (1986) (423)
Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. (2012) (420)
Post-translational modifications of tau protein in Alzheimer’s disease (2005) (417)
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. (1997) (414)
Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain (2000) (407)
DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE (1986) (393)
Distribution, Levels, and Activity of Glycogen Synthase Kinase‐3 in the Alzheimer Disease Brain (1997) (344)
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. (2009) (326)
Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein (1992) (310)
Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease (1996) (309)
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease (2008) (305)
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. (1998) (298)
Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations* (2004) (277)
Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B (*) (1995) (266)
Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. (1989) (246)
Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention (2007) (233)
Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus (2008) (231)
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration (1998) (223)
Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. (2009) (219)
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. (2002) (218)
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. (1999) (217)
A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse) (2013) (213)
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. (2005) (210)
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome (2008) (203)
Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease (1991) (186)
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. (2006) (185)
Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. (2002) (181)
τ is phosphorylated by GSK‐3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A‐kinase (1998) (180)
Role of protein phosphatase‐2A and ‐1 in the regulation of GSK‐3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain (2000) (179)
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK‐3β (2002) (179)
Alzheimer's disease, a multifactorial disorder seeking multitherapies (2010) (178)
Site‐specific effects of tau phosphorylation on its microtubule assembly activity and self‐aggregation (2007) (177)
Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration* (2010) (172)
Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia (2004) (169)
Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain* (2005) (169)
Alzheimer paired helical filaments Restoration of the biological activity by dephosphorylation (1994) (167)
Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain* (2004) (167)
Brain glucose transporters, O‐GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease (2009) (166)
Role of protein kinase B in Alzheimer's neurofibrillary pathology (2003) (164)
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains (1994) (164)
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers (2005) (163)
Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. (1996) (159)
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. (2001) (159)
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. (2001) (158)
Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A (1994) (157)
PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. (2010) (155)
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau (2007) (155)
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration (2004) (154)
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases (2009) (148)
An Antigenic Profile of Lewy Bodies: Immunocytochemical Indication for Protein Phosphorylation and Ubiquitination (1989) (148)
Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome*♦ (2008) (146)
Alzheimer's Disease Abnormally Phosphorylated τ Is Dephosphorylated by Protein Phosphatase‐2B (Calcineurin) (1994) (146)
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. (1989) (143)
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. (2003) (141)
Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. (1992) (139)
Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease (2002) (137)
Dephosphorylation of Tau by Protein Phosphatase 5 (2005) (133)
Lewy Bodies Contain Epitopes Both Shared and Distinct from Alzheimer Neurofibrillary Tangles (1988) (130)
Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments. (1988) (129)
Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles. (1998) (129)
Dephosphorylation of microtubule‐associated protein tau by protein phosphatase‐1 and ‐2C and its implication in Alzheimer disease (1994) (128)
Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid‐treated SY5Y cells (2001) (127)
Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5 (1997) (127)
The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease (2003) (123)
EVIDENCE THAT ALZHEIMER NEUROFIBRILLARY TANGLES ORIGINATE FROM NEUROTUBULES (1979) (122)
Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies. (2008) (121)
Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. (2006) (121)
Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis (2007) (120)
The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases (1998) (119)
Down‐regulation of cAMP‐dependent protein kinase by over‐activated calpain in Alzheimer disease brain (2007) (117)
PKA modulates GSK‐3β‐ and cdk5‐catalyzed phosphorylation of tau in site‐ and kinase‐specific manners (2006) (113)
Anesthesia induces phosphorylation of tau. (2009) (112)
Inhibition of PP‐2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356 (2001) (109)
Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients (2002) (107)
Dynamic Regulation of Expression and Phosphorylation of Tau by Fibroblast Growth Factor-2 In Neural Progenitor Cells from Adult Rat Hippocampus (1999) (105)
Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective. (2006) (101)
Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2 PP2A/SET (2011) (100)
Metabolic/signal transduction hypothesis of Alzheimer’s disease and other tauopathies (2005) (99)
Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5 (2002) (97)
Role of tau phosphorylation by glycogen synthase kinase-3β in the regulation of organelle transport (2004) (96)
Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism‐dementia of guam (1989) (92)
Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease* (2013) (91)
Brain ubiquitin is markedly elevated in Alzheimer disease (1991) (91)
τ and ubiquitin in the human hypothalamus in aging and Alzheimer's disease (1992) (88)
Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation (2012) (87)
Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A (2011) (86)
Modulation of GSK‐3‐catalyzed phosphorylation of microtubule‐associated protein tau by non‐proline‐dependent protein kinases (1995) (86)
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice (2010) (85)
Phosphorylation of τ Protein by Casein Kinase‐1 Converts It to an Abnormal Alzheimer‐Like State (1995) (84)
Cell surface immunoglobulin. VII. Synthesis, shedding, and secretion of immunoglobulin by lymphoid cells of germ-free mice. (1974) (84)
Targeting Tau Protein in Alzheimer’s Disease (2010) (84)
Defective brain microtubule assembly in Alzheimer??s disease (1987) (81)
Inactivation of glycogen synthase kinase‐3 by protein kinase C δ: implications for regulation of τ phosphorylation (2000) (81)
Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion* (2012) (81)
Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain (2000) (80)
Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam (2014) (80)
Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals (1994) (79)
Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain (2011) (78)
Inhibitors of protein phosphatase‐2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau (2005) (78)
Rapid Alzheimer‐like phosphorylation of tau by the synergistic actions of non‐proline‐dependent protein kinases and GSK‐3 (1995) (77)
Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly. (2008) (77)
Ser‐262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK (1998) (77)
Regulation between O‐GlcNAcylation and phosphorylation of neurofilament‐M and their dysregulation in Alzheimer disease (2008) (76)
Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels (1994) (75)
Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease. (2011) (75)
Calcium/calmodulin‐dependent protein kinase II phosphorylates tau at Ser‐262 but only partially inhibits its binding to microtubules (1996) (75)
Dephosphorylation of microtubule‐associated protein tau by protein phosphatase 5 (2003) (75)
An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide (2011) (75)
Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies (2015) (74)
The carboxy‐terminal fragment of inhibitor‐2 of protein phosphatase‐2A induces Alzheimer disease pathology and cognitive impairment (2010) (74)
Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target (2006) (74)
Regulation of phosphorylation of tau by cyclin‐dependent kinase 5 and glycogen synthase kinase‐3 at substrate level (2006) (70)
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences (1987) (69)
I PP2A 1 Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2A* (2008) (69)
Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease (1989) (69)
Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices (2003) (68)
Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease (2008) (67)
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach. (2000) (65)
Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide (2011) (65)
Analysis of N‐glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease (2001) (64)
Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s Disease (2012) (64)
Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage. (2009) (63)
Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. (2010) (61)
Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid β-protein (1989) (61)
Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures (2013) (60)
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain (2004) (60)
The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer. (1991) (60)
Subcellular distribution of protein phosphatases and abnormally phosphorylated τ in the temporal cortex from Alzheimer's disease and control brains (1998) (60)
Microtubule associated protein tau binds to double-stranded but not single-stranded DNA (2003) (58)
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration (2002) (57)
Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I2PP2A) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau* (2014) (57)
Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains (2006) (56)
Abnormally phosphorylated tau in SY5Y human neuroblastoma cells (1995) (55)
A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (1991) (55)
Experimental allergic encephalomyelitis Characterization of serum factors causing demyelination and swelling of myelin (1981) (54)
Silver Labeling of Alzheimer Neurofibrillary Changes and Brain β-Amyloid (1993) (54)
Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10 (2011) (53)
Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia. (1975) (53)
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer’s disease (2013) (53)
Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A (2012) (52)
Significance and mechanism of alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion (2002) (52)
Blood-brain barrier in Alzheimer dementia and in non-demented elderly (1987) (51)
TAU AND UBIQUITIN IMMUNOREACTIVITY AT DIFFERENT STAGES OF FORMATION OF ALZHEIMER NEUROFIBRILLARY TANGLES (1989) (50)
Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated τ by neuroleptics (1996) (49)
Alzheimer neurofibrillary tangles: Antiserum and immunohistological staining (1979) (49)
OLIGODENDROGLIA FROM HUMAN AUTOPSIED BRAIN: BULK ISOLATION AND SOME CHEMICAL PROPERTIES 1 (1977) (47)
Multiple sclerosis (1980) (46)
Neurofibrillary and Synaptic Pathology in the Aged Brain (1981) (46)
ALZHEIMER'S DISEASE AND RELATED CONDITIONS (1987) (46)
Opportunities and challenges in developing Alzheimer disease therapeutics (2011) (45)
Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules (1978) (45)
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease. (2009) (45)
Alzheimer paired helical filaments: Immunochemical identification of polypeptides (2004) (45)
Bilateral injection of isoproterenol into hippocampus induces Alzheimer‐like hyperphosphorylation of tau and spatial memory deficit in rat (2005) (44)
Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice (2010) (43)
Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease. (2002) (42)
Pathogenesis of neuritic (senile) and amyloid plaque formation. (1982) (42)
Phosphothreonine-212 of Alzheimer Abnormally Hyperphosphorylated Tau is a Preferred Substrate of Protein Phosphatase-1 (2005) (40)
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. (2008) (40)
Mechanism of neurofibrillary degeneration in Alzheimer's disease (1994) (39)
Chronic relapsing experimental allergic encephalomyelitis. Immunohistochemical studies. (1980) (39)
Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice. (2010) (39)
Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. (2001) (39)
Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s) (2004) (38)
Developing pharmacological therapies for Alzheimer disease (2007) (38)
Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease. (2011) (37)
Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation. (2000) (37)
Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases (1994) (37)
PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau (2006) (37)
Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells (1999) (36)
Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells (2012) (36)
Regulation of Phosphorylation of tau by Protein Kinases in Rat Brain (2000) (36)
Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies. (2004) (36)
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: A biomarker of blood–cerebrospinal fluid barrier permeability (2010) (36)
Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein τ: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid (1992) (35)
Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease. (1992) (35)
ON NEUROFILAMENT and NEUROTUBULE PROTEINS FROM HUMAN AUTOPSY TISSUE (1977) (35)
Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain (1996) (35)
Molecular Mechanism of Alzheimer's Neurofibrillary Degeneration and Therapeutic Intervention a (1996) (34)
Elevated Levels of τ and Ubiquitin in Brain and Cerebrospinal Fluid in Alzheimer's Disease (1997) (34)
The organization of the microtubule associated protein tau in Alzheimer paired helical filaments (1993) (33)
Pharmacological approaches of neurofibrillary degeneration. (2005) (33)
Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases. (1996) (32)
Neurofibrillary Pathology: An Update (1977) (32)
Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau (2005) (31)
Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules (1995) (30)
Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome (2011) (29)
Effect of Melatonin and Melatonylvalpromide on β-amyloid and Neurofilaments in N2a Cells (2008) (28)
Perivascular deposits of serum proteins in cerebral cortex in vascular dementia (2004) (27)
PAIRED HELICAL FILAMENT ANTIGEN IN CSF (1985) (27)
Protein abnormalities in Huntington's chorea. (1974) (26)
About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation (2004) (26)
Guanosine Triphosphate Binding to β‐Subunit of Tubulin in Alzheimer's Disease Brain: Role of Microtubule‐Associated Protein τ (1995) (26)
Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection (2014) (26)
Levels of tau phosphorylation at different sites in Alzheimer disease brain (1998) (25)
Novel therapeutic strategies for neurodegenerative disease (2009) (25)
Are Alzheimer neurofibrillary tangles insoluble polymers? (1986) (25)
A pool of β‐tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain (2001) (25)
Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats. (2015) (24)
NF-κB precursor, p105, and NF-κB inhibitor, IκBγ, are both elevated in Alzheimer disease brain (2005) (24)
Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: Negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation (2005) (24)
Sera from Children with Autism Induce Autistic Features Which Can Be Rescued with a CNTF Small Peptide Mimetic in Rats (2015) (22)
Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles (1997) (21)
Molecular pathology of Alzheimer neurofibrillary degeneration. (1993) (21)
Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid (2004) (21)
Multiple sclerosis: Immunochemical studies on the demyelinating serum factor (1979) (21)
Inhibitors of protein phosphatase-2A: topography and subcellular localization. (2004) (20)
Alzheimer disease is multifactorial and heterogeneous (2000) (20)
Splicing factor SC35 promotes tau expression through stabilization of its mRNA (2011) (19)
Studies on the encephalitogenic effects of purified preparations of human and bovine oligodendrocytes (1977) (19)
Alzheimer disease hyperphosphorylated tau aggregates hydrophobically (1997) (19)
Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates (1997) (19)
Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice. (2011) (18)
Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment (2015) (18)
Hyperphosphorylated tau in SY5Y cells: similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain (1999) (17)
Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration. (2002) (17)
Alzheimer paired helical filaments: Identification of polypeptides with monoclonal antibodies (2004) (16)
Tau pathology generated by overexpression of tau. (1999) (16)
ALZHEIMER'S DISEASE, MICROTUBULE AND NEUROFILAMENT PROTEINS, AND AXOPLASMIC FLOW (1987) (16)
Neurofibrillary Pathology in Subacute Sclerosing Panencephalitis (1991) (16)
NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain. (2005) (15)
Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease. (1995) (15)
Tau in cerebrospinal fluid: A sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification (2007) (15)
Biological markers in Alzheimer's disease. (2006) (14)
Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Nonbinding Phosphatase Activities (2001) (14)
MICROTUBULE ASSOCIATED PROTEIN, TAU IS A MAJOR CONSTITUENT OF ALZHEIMER PAIRED HELICAL FILAMENTS (1986) (14)
Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex (2005) (13)
40 ISOLATION AND PROPERTIES OF ALZHEIMER NEUROFIBRILLARY TANGLES (1981) (13)
Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles. (1992) (11)
In vitro analysis of tau phosphorylation sites and its biological activity. (2002) (11)
A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer’s Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse) (2012) (11)
NEURONAL CYTOSKELETON IN THE BIOLOGY OF ALZHEIMER DISEASE (1989) (11)
Alzheimer Neurofibrillary tangle: morphology and biochemistry. (1982) (10)
In vitro assembly and isolation of neurofilaments and microtubules from mammalian CNS. (1987) (10)
Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau. (1995) (10)
Young adult-form of dementia with neurofibrillary changes and lewy bodies (2004) (10)
Multiple Forms of Phosphatase from Human Brain: Isolation and Partial Characterization of Affi-Gel Blue Binding Phosphatases (2004) (10)
Alzheimer paired helical filaments: Cross-reacting polypeptide/s normally present in brain (2004) (10)
I 1 PP 2 A Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2 A * (2008) (10)
Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells. (2004) (10)
Neuronal cytoskeleton in aging and dementia. (1986) (9)
Tau phosphatase activity as a therapeutic target for AD. (1998) (9)
Microtubule‐associated protein tau Identification of a novel peptide from bovine brain (1989) (9)
A SILVER IMPREGNATION METHOD SPECIFIC FOR ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) STAINS MICROTUBULE ASSOCIATED PROTEIN TAU.: 4 (1987) (8)
Cell surface immunoglobulin. VI. Dynamics on a human lymphoma line (1974) (8)
49 STUDIES ON MAMMALIAN NEUROFILAMENTS ISOLATED BY IN VITRO ASSEMBLY-DISASSEMBLY (1981) (8)
Alterations of the Neuronal Cytoskeleton in Alzheimer’s Disease and Related Conditions (1987) (8)
Laboratory diagnostic tests for Alzheimer's disease. (1989) (7)
Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease. (2008) (7)
P.4.018 Memantine restores okadaic acid-induced changes in the activities of protein phosphatase-2A, CaMKII and hyperphosphorylation of tau in rat hippocampal slices in culture (2003) (6)
DEMYELINATING SERUM FACTORS IN PATIENTS WITH MS AND NORMAL HUMANS ARE DIFFERENT: 46 (1979) (6)
Immunocytochemical studies on neurofibrillary changes. (1982) (6)
IMMUNE ELECTRON MICROSCOPY OF PAIRED HELICAL FILAMENTS (PHF) WITH TAU ANTIBODIES: 132 (1987) (5)
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease (2011) (5)
Phosphorylation and accumulation of tau without any concomitant increase in tubulin levels in Chinese Hamster Ovary cells stably transfected with human tau441 (1995) (5)
ARE DEMYELINATING SERUM FACTORS IN MS AND EAE GAMMA GLOBULINS?: 106 (1977) (5)
Alzheimer Neurofibrillary Degeneration: A Feasible and Key Target for Therapeutics (1997) (5)
P3-329 I1 PP2A and I2 PP2A affect tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A (2006) (4)
79 STUDIES ON ALZHEIMER NEUROFIBRILLARY TANGLE CROSS-REACTING ANTIGEN/S (1980) (4)
MICROTUBLE ASSOCIATED PROTEIN, TAU IS ABNORMALLY PHOSPHORYLATED IN ALZHEIMER BRAIN (1986) (4)
The solubility controversy of paired helical filaments: A commentary (2004) (4)
Cerebrospinal Fluid Secretory Ca 2 -Dependent Phospholipase A 2 Activity Is Increased in (2009) (4)
MICROTUBULE ASSOCIATED PROTEIN TAU IN ALZHEIMER PAIRED HELICAL FILAMENTS (PHF): HOW MUCH? (1987) (3)
159 IDENTIFICATION OF ALZHEIMER PAIRED HELICAL FILAMENT POLYPEPTIDES WITH MONOCLONAL ANTIBODIES (1984) (3)
Glycosylation of tau protein occurs earlier than its hyperphosphorylation in Alzheimer's disease (2000) (3)
Ubiquitin in cerebrospinal fluid: a rapid competitive enzyme‐linked immunoflow assay (1994) (3)
Erratum: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease (Journal of Neurochemistry 85 (1101-1108)) (2003) (3)
IMMUNE ELECTRON MICROSCOPY OF ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) (1986) (3)
The peptidergic antidementia drug cerebrolysin increases neurogenesis in the adult rat dentate gyrus and improves spatial learning and memory (2000) (3)
Cytoskeletal alterations in the hypothalamus during aging and in Alzheimer's disease are not necessarily a marker for impending cell death (1991) (3)
Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation (2006) (2)
Neurogenesis: A Promising Therapeutic Target for Alzheimer Disease and Related Disorders (2004) (2)
168 Differential phosphorylation of three-repeat human tau isoforms by several protein kinases (1996) (2)
Mechanism of neurofibrillary degeneration (2000) (2)
MULTIPLE SCLEROSIS: STUDIES ON THE IN VITRO DEMYELINATING SERUM FACTOR (1978) (2)
Restoration of the biological activity by dephosphorylation (1994) (2)
Pivotal Role of Neurofibrillary Degeneration in Alzheimer Disease and Therapeutic Targets (2004) (2)
534 Tau-pathology in brain of rats after chronic treatment with okadaic acid (1996) (2)
S5-02-05 Involvement of aberrant regulation of PI3K and MAPK cascades in AD TAU phosphorylation (2004) (2)
ARE NEUROTUBULE PROTEINS INVOLVED IN THE FORMATION OF ALZHEIMER NEUROFIBRILLARY TANGLES?: 65 (1979) (2)
CREB regulates the expression of neuronal glucose transporter 3: A mechanism leading to impaired brain glucose uptake in Alzheimer's disease (2012) (1)
Abnormal hyperphosphorylation of non-tau proteins in Alzheimer's disease brain (2000) (1)
A novel etiopathogenic mechanism and a disease-relevant non-transgenic rat model of Alzheimer's disease (2010) (1)
P3-251 Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain (2004) (1)
PAIRED HELICAL FILAMENT (PHF) IMMUNOREACTIVITY IN CSF (1988) (1)
Overexpression of inhibitor-1 or -2 of protein phosphatase-2A causes abnormal hyperphosphorylation of tau and cognitive impairment in the rat (2009) (1)
ABNORMALLY PHOSPHORYLATED TAU IN ALZHEIMER DISEASE BRAIN: ROLE OF PHOSPHOPROTEIN PHOSPHATASES (1993) (1)
O2-01-02 Treat abnormal hyperphosphorylation and not aggregation of tau (2006) (1)
Subgroups of Alzheimer disease based on levels of CSF tau, ubiquitin and Aβ1−42 (2000) (1)
P4-425 High throughput screen assays of inhibition of PP-2A catalyzed dephosphorylation of abnormally hyperphosphorylated tau by I1PP2A and I2PP2A (2004) (1)
P3-063: CSF phospholipase A2 activity is a biomarker of blood brain barrier permeability but not Alzheimer's disease (2008) (1)
Chronic treatment with a CNTF peptide enhances neuronal plasticity and alleviates cognitive impairment in 3xTgAD mice (2010) (1)
P2-128 Regulation of microtubule-associated proteins, protein kinases, and protein phosphatases during differentiation of SY5Y cells (2004) (1)
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase 2A and 2B J.Z. Wang, C.-X. Gong, I. Grundke-Iqbal and K. Iqbal. NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 USA (1994) (1)
109 RELATIONSHIP OF ALZHEIMER PAIRED HELICAL FILAMENTS WITH MICROTUBULES AND NEUROFILAMENTS (1983) (1)
Alzheimer??s disease, microtubule and neurofilament proteins, and axoplasmic flow (1987) (1)
Tau Pathology as a Target in Alzheimer's Therapeutics (2007) (1)
Chapter 13:A Non-transgenic Rat Model of Sporadic Alzheimer's Disease (2011) (1)
MICROTUBULE ASSOCIATED PROTEIN TAU: IDENTIFICATION AND LOCALIZATION OF A NOVEL PEPTIDE TO ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) (1989) (1)
Neurogenic and neuroprotective effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures (2011) (0)
518 Secondary structure of Alzheimer disease abnormally hyperphosphorylated tau (AD P-Tau) before and after phosphate removal using hydroflouric acid: Correlation with high resolution TEM imaging (1996) (0)
In vitro self assembly of abnormally hyperphosphorylated tau into PHF-like structures (2000) (0)
Rabbit IgG cross-reacts with Alzheimer neurofibrillary tangles (1994) (0)
Molecular basis of cognitive improvement of pioglitazone and rosiglitazone (2010) (0)
P1-267 Alterations of glycoproteins in Alzheimer disease brain (2004) (0)
Metabolically active rat brain slices as a model for studying neurofibrillary degeneration of Alzheimer's disease (2000) (0)
O3-13-02 CHRONIC TREATMENT WITH A CNTF-DERIVED PEPTIDE REVERSES DENDRITIC AND SYNAPTIC PLASTICITY DEFICITS, COGNITIVE IMPAIRMENTAND TAU PATHOLOGY IN AN ALZHEIMER’S DISEASE MOUSE MODEL (2013) (0)
Cerebral ischemia-induced elevation of O-GlcNAcylation causes AKT inhibition and apoptosis (2012) (0)
533 Isolation of protein phosphatase 2B calcineurin from Alzheimer disease and control autopsied brains (1996) (0)
Role of protein kinases, protein phosphatases and extracellular signals in the abnormal hyperphosphorylation of tau (2000) (0)
P3-300 Increased tyrosine 307 phosphorylation of protein phosphatase-2A correlates with tau associated pathologies in Alzheimer’s disease (2006) (0)
Subgroups of Alzheimer disease based on cerebrospinal fluid levels of molecular markers (2005) (0)
Improvement of cognition by enhancing neurogenesis and neuronal plasticity with a CNTF peptidergic compound (2011) (0)
P3-263 Phosphorylation of tau is regulated by O-Glcnacylation (2004) (0)
Development of an ultrasensitive elisa-double enzyme amplification assay and quantitation of total and abnormally hyperphosphorylated taus in cerebrospinal fluid (2000) (0)
P2-145: Regulation of ASF-mediated alternative splicing of tau exon 10 by PKA (2008) (0)
QUANTITATION OF MICROTOBULE ASSOCIATED PROTEIN TAU IN PAIRED HELICAL FILAMENTS BY IMMUNOASSAY (1988) (0)
P3-264 A novel phosphoseryl/phosphothreonyl protein phosphatase activity that might be involved in the abnormal hyperphosphorylation of tau (2004) (0)
Chapter 15:Regeneration of Degenerated Brain: A Promising Therapeutic Target (2010) (0)
β-N-Methylamino-L-alanine could be involved in Alzheimer's neurofibrillary pathology in amyotrophic lateral sclerosis–Parkinsonism dementia complex (2013) (0)
AND A NON-TRANSGENIC MODEL OF ALZHEIMER’S DISEASE OF REGIONAL COVARIANCE IN MRI GRAY MATTER: REPRODUCIBLE MULTIVARIATE PATTERNS IN ALZHEIMER’S DISEASE, COGNITIVE (2010) (0)
Dysregulation of brain insulin signaling: A mechanistic link between diabetes and Alzheimer's disease (2010) (0)
299 Abnormal hyperphosphorylation of tau: An early and most significant deleterious event in neurofibrillary degeneration (1996) (0)
Chronic treatment with a CNTF peptide restores neurogenesis and alleviates memory deficit in Ts65Dn mice (2010) (0)
Role of Abnormal Phosphorylation of Tau in Neurofibrillary Degeneration: Implications for Alzheimer Therapy (1994) (0)
531 Glycosylation of microtubule associated ρ: An abnormal posttranslational modification in Alzheimer disease (1996) (0)
Alzheimer Neurofibrillary Tangles: Immunochemical Cross-Reactivity with Normal Brain Antigens (1985) (0)
The human hypothalamus and Alzheimer symptoms (1992) (0)
P4-339 Improvement of neurogenesis by cerebrolysin and its neurotrophic factors in adult rat hippocampal progenitors (2006) (0)
Central Role of Tau Protein in Alzheimer»S Disease and Related Tauopathies (2009) (0)
P3-254 Hyperphosphorylation induced self-assembly of murine tau: a comparison with human tau (2004) (0)
Biochemical Markers for Alzheimer Disease as Reflection of the Neuropathology in Cerebrospinal Fluid: (2020) (0)
O4-02-05: Molecular mechanism by which type 2 diabetes mellitus increases the risk for Alzheimer's disease (2008) (0)
S3-03-01 O-glycosylation regulates phosphorylation of tau:A novel mechanism leading to neurofibrillarydegeneration in Alzheimer disease (2006) (0)
S1-04-04 Mutations in tau gene lead to neurodegeneration by making tau a more favorable substrate for abnormal hyperphosphorylation (2004) (0)
Truncation of GSK-3β by activated calpain I in Alzheimer brain enhances its biological activity (2010) (0)
Abnormal hyperphosphorylation of tau: Participation of β-amyloid/peptide out and proline-directed protein kinases (PDPKs) and non-PDPKs in (1995) (0)
P3-246 Association of P70 S6 kinase with neurofibrillary degeneration in Alzheimer's disease (2004) (0)
163 ARE ALZHEIMER PAIRED HELICAL FILAMENT POLYPEPTIDES PRESENT NORMALLY IN BRAIN (1984) (0)
516 Expression of protein kinase GSK-3 and protein phosphatases PP-1, PP 2A, and PP-2B in the brain of patients with Alzheimer's disease (1996) (0)
Circulating Myelinotoxic and Neuroelectric Blocking Factors in Demyelinative Disorders (1982) (0)
Molecular pathology of Alzheimer neurofibrillary (2009) (0)
A FRAGMENT OF THE AMYLOID PRECURSOR PROTEIN IN NEURONAL LIPOFUSCIN?: 94 (1989) (0)
アルツハイマー病脳上清におけるモノクローナル抗体Tau-1とPHF-1を用いた非PHFリン酸化タウの定量 (1995) (0)
Development of neuropeptides that promote neurogenesis in models of Alzheimer's and Parkinson's disease (2009) (0)
MICROTUBULE ASSOCIATED PROTEIN TAU: IMMUNOCHEMICAL EVIDENCE FOR ITS PHOSPHORYLATION IN ALZHEIMER PAIRED HELICAL FILAMENTS (PHF) (1989) (0)
Role of Neurofibrillary Degeneration in Alzheimer’s Disease (1998) (0)
535 Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5 (1996) (0)
Abnormal ) PP 2 A 2 Phosphatase 2 A Inhibitor 2 ( I Cytoplasmic Retention of Protein Neurobiology : (2014) (0)
Chronic treatment with a CNTF-derived peptide reverses dendritic and synaptic plasticity deficits, cognitive impairment and tau pathology in an Alzheimer's disease mouse model (2013) (0)
CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: A CLINICO PATHOLOGICAL CORRELATION (1978) (0)
P2-147: Modulation of SRp55-regulated alternative splicing of tau exon 10 by Dyrk1A (2008) (0)
O-GlcNAcylated tau: A link between impaired glucose metabolism and neurodegeneration in Alzheimer's disease (2012) (0)
CELL SURFACE IMMUNOGLOBULIN (1974) (0)
110 SOLUBILITY AND PROTEIN COMPOSITION OF ALZHEIMER NEUROFIBRILLARY TANGLES (1983) (0)
Asparagine Endopeptidase (AEP) is activated in Alzheimer's disease brain and induces I2PP2A cleavage (2011) (0)
A protein phosphatase-2A-based etiopathogenic mechanism of Alzheimer's disease (2010) (0)
621 The regulation of phosphorylation of Tau in SYSY neuroblastoma cells (1996) (0)
Overexpression of tau associates with differentiation of neuronal cells in culture (2000) (0)
P2-155: Phosphorylation of SC35 by Dyrk1A inhibits its promotion of tau exon 10 inclusion (2008) (0)
O2-05-08: Protein O-Glcnacylation: A novel mechanism involved in Alzheimer's disease (2008) (0)
Truncation and activation of Dyrk1A in Alzheimer's disease brain by activated calpain I (2009) (0)
Alzheimer Neurofibrillary Tangles: Biochemical Properties (1985) (0)
Differential regulation of the alternative splicing of tau exon 10 by protein kinase A isoforms (2011) (0)
P3-304 Mnb/Dyrk1A primes phosphorylation of tau at several phosphorylation sites by GSK-3β (2006) (0)
Hyperphosphorylation and accumulation of neurofilament protein subunits in Alzheimer disease brain (2000) (0)
Reversal Of Cognitive Impairment By Pharmacologic Neuroregeneration: A Novel Therapeutic Approach (2010) (0)
Truncation of GSK-3beta by calpain I contributes to the hyperphosphorylation of tau in the Alzheimer's brain (2012) (0)
MICROTUBULE ASSOCIATED PROTEIN TAU: STRUCTURAL FEATURES AND ITS RELATIONSHIP TO ALZHEIMER'S NEUROFIBRILLARY TANGLES (1988) (0)
Kinase–Kinase and Site–Site Interactions in the Phosphorylation of Tau by GSK‐3 (2006) (0)
P2-445: Enhancement of dentate gyrus neurogenesis and associated memory by a neurotrophic peptide (2008) (0)
620 Interaction between Alzheimer disease abnormally phosphorylated Tau and microtubule associated proteins (1996) (0)
Neurofibrillary degeneration: a promising target for the treatment of Alzheimer’s disease and other tauopathies K Iqbal, A del C Alonso, E El-Akkad, C-X Gong, N Haque, S Khatoon, H Tanimukai, (2005) (0)
Rescue of cognitive impairment and neuronal plasticity with a neurotrophic peptide in a rat model of sporadic Alzheimer's disease (2012) (0)
536 Tau in Alzheimer disease brain is phosphorylated to different degrees at different sites (1996) (0)
COMPARATIVE NEUROTERATOGENICITY OF METHLAZOXYMETHANOL ACETATE (MAM AC) AND 5-AZACYTIDINE (AZC): 48 (1979) (0)
P3-240 I1 PP2A and I2 PP2A interact with the catalytic subunit of protein phosphatase 2A (2004) (0)
O2-01-06 Inhibition of more than one tau kinase might be required for prevention of Alzheimer disease (2007) (0)
S2-04-02 Treatment of Alzheimer and other tauopathies by inhibition of neurofibrillary degeneration (2004) (0)
P3-248 Activation of calpain I in Alzheimer disease brain negatively regulates CREB (2006) (0)
319 Alterations of presenilin I in fibroblasts from familial Alzheimer disease patients (1996) (0)
MICROTUBULE ASSOCIATED PROTEIN TAU IN ALZHEIMER PAIRED HELICAL FILAMENTS (PHF): HOW MUCH? 134 (1987) (0)
O4-05-04 Regeneration of the brain: a promising approach to neurodegeneration and disorders of learning and memory (2004) (0)
P1-358 Enhancement of neurogenesis by neurotrophic factors: a therapeutic approach to Alzheimer disease (2004) (0)
Excitotoxic damage deregulates tau phosphorylation: Implication to Alzheimer's disease (2009) (0)
572 Role of abnormal phosphorylation and glycosylation of tau in the formation of tangles and neurofibrillary degeneration (1996) (0)
MULTIPLE SCLEROSIS: NON-GAMMA GLOBULIN SERUM FACTORS AND DEMYELINATION IN ORGAN CULTURE (1980) (0)
[Association of microtubule promoting and binding activity of tau with its phosphorylation sites]. (2000) (0)
Chronic treatment with an 11-mer CNTF peptide rescues synaptic deficit and cognitive impairment in a rat model of sporadic Alzheimer's disease (2011) (0)
128 CELLULAR LOCALIZATION OF MEASLES VIRUS DURING PERSISTENCE AND REACTIVATION (1983) (0)
P2-129 Tau and a cell culture model of microtubule stability (2004) (0)
7 Tau and Ubiquitin as diagnostic markers of Alzheimer disease (1996) (0)
IMMUNE ELECTRON MICROSCOPY OF MONOCLONAL ANTIBODIES TO ALZHEIMER NEUROFIBRILLARY TANGLES: 5 (1987) (0)
515 Isolation of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinase-S (cdk-S) from Alzheimer disease and control brains (1996) (0)
I 1PP2A AFFECTS TAU PHOSPHORYLATION VIA ASSOCIATION WITH THE CATALYTIC SUBUNIT OF PROTEIN PHOSPHATASE 2A (2008) (0)
Dyrk 1 A regulate the alternative splicing of tau exon 10 1 Dual-specificity tyrosine-phosphorylated and regulated kinase 1 A ( Dyrk 1 A ) modulates serine-arginine rich protein 55 ( SRp 55 )-promoted tau exon (2012) (0)
P2-142: Decreased protein phosphatase 2A in Down syndrome brain: A cause of neurofibrillary degeneration (2008) (0)
532 Differentiation of SYSY cells: Effect on phosphorylation and biological activity of tau (1996) (0)
Alzheimer subgroups: towards effective drug development (2007) (0)
S4-01-01 Identification of subgroups of Alzheimer disease (2006) (0)
37 Promise and feasibility of inhibition of Tau's abnormal hyperphosphorylation (2012) (0)
Chapter 7:Alzheimer Neurofibrillary Degeneration: Pivotal Role and Therapeutic Targets (2010) (0)
Development of neurotrophic peptides for enhancement of neurogenesis and associated behavioral improvement (2009) (0)
P3-292 High throughput screen assay to develop drugs for inhibition of abnormal hyperphosphorylation of tau (2006) (0)
1st Conference Clinical Trials on Alzheimer’s Disease September 17-18-19, 2008 School of Medecine Montpellier, France (2008) (0)
Technical Advance Levels of Nonphosphorylated and Phosphorylated Tau in Cerebrospinal Fluid of Alzheimer’s Disease Patients An Ultrasensitive Bienzyme-Substrate-Recycle Enzyme-Linked Immunosorbent Assay (2002) (0)
O2-05-06 Impaired glucose uptake/metabolism contributes to hyperphosphorylation of tau via reduction of O-GLCnacylation: a novel mechanism involved in Alzheimer disease (2004) (0)
Regulation of Akt by O-GlcNAcylation in various cell types: implication in Alzheimer's Disease (2010) (0)
Overexpression of Dyrk1A dysregulates the alternative splicing of tau exon 10 (2010) (0)
165 COMPARISON OF BRAIN AND PERIPHERAL INFLAMMATORY CELLS IN CHRONIC RELAPSING EAE (1983) (0)
O4-04-08: Improvement of cognition with a neurogenic/neurotrophic peptide (2008) (0)
A 31 kilodalton beta-protein immunoreactive polypeptide in neuronal lipofuscin. (1989) (0)
P3-337 Enhancement of neurogenesis by peptides: A promising therapeutic approach (2006) (0)
Neurofibrillary degeneration: a promising target for the treatment of Alzheimer’s disease and other tauopathies (2005) (0)
P3-224 Inhibitors of protein phosphatase-2A colocalize with the abnormally hyperphosphorylated tau in Alzheimer disease (2004) (0)

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