Inke Nathke
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German cell biologist
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Inke Nathkebiology Degrees
Biology
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Cell Biology
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Molecular Biology
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Biology
Why Is Inke Nathke Influential?
(Suggest an Edit or Addition)According to Wikipedia, Inke Näthke is a German-British cell biologist. She is Professor of Epithelial Biology at the Department of Cell & Developmental Biology, Interim Dean and Associate Dean for Professional Culture at the School of Life Sciences at the University of Dundee in Scotland. She is known for her work on the role of the adenomatous polyposis coli protein in colorectal cancer.
Inke Nathke's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. (2004) (802)
- Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly (1994) (654)
- A role for the Adenomatous Polyposis Coli protein in chromosome segregation (2001) (592)
- Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. (1997) (580)
- The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration (1996) (528)
- Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation (2001) (462)
- Cell polarity in development and cancer (2007) (358)
- Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells (1994) (343)
- The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. (2004) (259)
- Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. (2010) (257)
- A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin (1999) (256)
- Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis (2007) (178)
- Folding and trimerization of clathrin subunits at the triskelion hub (1992) (164)
- The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells (2002) (160)
- Cell regulation by the Apc protein Apc as master regulator of epithelia. (2008) (137)
- DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage (2012) (137)
- Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC (2006) (136)
- Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. (2006) (126)
- Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. (2007) (125)
- Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. (1994) (123)
- Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics. (1991) (105)
- 100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis. (1989) (98)
- Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo (2010) (95)
- The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. (2004) (90)
- The adenomatous polyposis coli protein: in the limelight out at the edge. (2001) (88)
- Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance (2013) (83)
- The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium (2011) (79)
- Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche (2016) (72)
- Changes in cell and tissue organization in cancer of the breast and colon. (2014) (69)
- Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer (2017) (66)
- Redefining the subcellular location and transport of APC: new insights using a panel of antibodies (2005) (63)
- Epithelial cell adhesion and development of cell surface polarity: possible mechanisms for modulation of cadherin function, organization and distribution (1993) (59)
- Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost (2013) (56)
- Computational Models Reveal a Passive Mechanism for Cell Migration in the Crypt (2013) (55)
- The adenomatous polyposis coli protein. (1999) (54)
- Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection (2010) (51)
- A Two-Dimensional Model of the Colonic Crypt Accounting for the Role of the Basement Membrane and Pericryptal Fibroblast Sheath (2012) (46)
- Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains. (2005) (45)
- The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions (2005) (44)
- APC at a glance (2004) (41)
- Preparation of wholemount mouse intestine for high‐resolution three‐dimensional imaging using two‐photon microscopy (2009) (39)
- The calcium-binding site of clathrin light chains. (1990) (39)
- Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol (2010) (38)
- Novel self-association of the APC molecule affects APC clusters and cell migration (2008) (36)
- Lgr5+ intestinal stem cells reside in an unlicensed G1 phase (2018) (36)
- Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems (2012) (34)
- Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis. (2006) (31)
- Microtubule assembly by the Apc protein is regulated by importin-β—RanGTP (2010) (29)
- Stem cell decisions: A twist of fate or a niche market? (2014) (28)
- The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively (2012) (28)
- High-Energy Particle-Induced Tumorigenesis Throughout the Gastrointestinal Tract (2014) (26)
- Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network (2014) (24)
- Ultrasound capsule endoscopy: sounding out the future. (2017) (24)
- Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation. (2005) (21)
- Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids (2017) (21)
- Catch and pull a microtubule: getting a grasp on the cortex (2001) (18)
- Adenomatous Polyposis Coli on Microtubule Plus Ends in Cell Extensions Can Promote Microtubule Net Growth with or without EB 1 (2006) (18)
- Antagonistic crosstalk between APC and HIF-1α (2011) (17)
- Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts (2016) (17)
- Increased variability in ApcMin/+ intestinal tissue can be measured with microultrasound (2016) (17)
- The cadherin/catenin complex: connections to multiple cellular processes involved in cell adhesion, proliferation and morphogenesis (1995) (17)
- The Adenomatous Polyposis Coli Protein Contributes to Normal Compaction of Mitotic Chromatin (2012) (15)
- Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells (2018) (12)
- A Multicellular Model of Intestinal Crypt Buckling and Fission (2018) (12)
- A Prototype Therapeutic Capsule Endoscope for Ultrasound-Mediated Targeted Drug Delivery (2018) (12)
- A Learning-Based Microultrasound System for the Detection of Inflammation of the Gastrointestinal Tract (2020) (12)
- Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway. (2001) (11)
- Microultrasound characterisation of ex vivo porcine tissue for ultrasound capsule endoscopy (2017) (11)
- Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy (2017) (10)
- Prognostic and therapeutic implications of Apc mutations in colorectal cancer. (2008) (10)
- Development of a therapeutic capsule endoscope for treatment in the gastrointestinal Tract: Bench testing to translational trial (2017) (9)
- SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo (2017) (8)
- Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22 (2018) (8)
- Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall (2021) (7)
- Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling (2016) (7)
- Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin–Independent Targets by Proteomics (2019) (6)
- Ultrasound and Microbubbles Promote the Retention of Fluorescent Compounds in the Small Intestine (2018) (6)
- Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material (2016) (5)
- Theranostics in the gut (2018) (4)
- Sonopill: A Platform for Gastrointestinal Disease Diagnosis and Therapeutics (2016) (4)
- Is familial adenomatous polyposis associated with sensorineural hearing loss? (2010) (4)
- Faculty Opinions recommendation of ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. (2003) (3)
- An in vitro sonication system for applications in ultrasound-mediated targeted drug delivery (2016) (3)
- differentiation , and migration Loss of Apc in vivo immediately perturbs Wnt signaling , Material (2004) (3)
- Endocytosis: Molecular Mechanism and Role in the Immune Response (1992) (2)
- Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions (2017) (2)
- Inke Nathke: The ABCs of APC. Interview by Caitlin Sedwick. (2010) (2)
- Postmitotic separation enables selective niche retention of one daughter cell in intestinal crypts and is facilitated by interkinetic nuclear migration and basal tethering (2017) (1)
- Importance of the Niche: Wnt Signaling and Stem Cell Plasticity in Intestinal Homeostasis and Disease (2013) (1)
- Tu1905 β-Catenin Complexes in Colorectal Cancer and Their Functional Implications (2015) (1)
- An Organoid-derived Cell Layer as an in vitro Model for US-mediated Drug Delivery Studies (2020) (1)
- Development of a therapeutic capsule endoscope for treatment in the gastrointestinal tract: Bench testing to translational trial (2017) (1)
- A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery (2017) (1)
- The Oligomerization Domains of the APC Protein Mediate Liquid-Liquid Phase Separation That Is Phosphorylation Controlled (2023) (1)
- Faculty Opinions recommendation of Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. (2003) (1)
- Manipulating the Barrier Function of a Cell Monolayer Using a High-power Miniature Ultrasonic Transducer (2021) (1)
- The adenomatous polyposis coli tumour-suppressor protein in normal gut tissue maintenance and cancer (2008) (0)
- Cell-to-cell contact and extracellular matrix: Laying down the rules for proper cell behavior (2005) (0)
- BioEssays – Next Issue (2014) (0)
- Ultrasound Mediated Delivery of Quantum Dots from a Capsule Endoscope to the Gastrointestinal Wall (2020) (0)
- APC proteins. Preface. (2009) (0)
- Structural Analysis of the Clathrin Triskelion (1993) (0)
- The Art and Science of Cell Biology (ASCB 2 ) (2012) (0)
- Abstract SY07-01: The adenomatous polyposis coli protein makes multiple contributions to architecture of gut epithelial cells and tissue (2011) (0)
- The adenomatous polyposis coli protein 3o years on (2022) (0)
- Delayed activation of the DNA replication licensing system in Lgr5(+) intestinal stem cells (2017) (0)
- Faculty Opinions recommendation of Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. (2003) (0)
- Faculty Opinions recommendation of Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism. (2004) (0)
- Correction 176, p. 183 (2007) (0)
- Investigation into the Acoustic Transparency of Reconstituted Mucus (2022) (0)
- Response to Legraverend et al. (2010) (0)
- Faculty Opinions recommendation of Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. (2004) (0)
- Faculty Opinions recommendation of Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. (2005) (0)
- University of Dundee Increased variability in ApcMin / + intestinal tissue can be measured with (2016) (0)
- M1954 A Role for the APC Protein in Intestinal Crypt Fission Examined By Multi-Photon Microscopy (2009) (0)
- Faculty Opinions recommendation of The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. (2008) (0)
- Acoustic radiation pressure as a versatile tool for cell compression and mechanobiology studies (2017) (0)
- Faculty Opinions recommendation of A core function for p120-catenin in cadherin turnover. (2003) (0)
- Faculty Opinions recommendation of A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation. (2006) (0)
- Nanotechnology in multimodal theranostic capsule endoscopy (2017) (0)
- Faculty Opinions recommendation of Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus. (2003) (0)
- Faculty Opinions recommendation of Coordination of cell growth and cell division: a mathematical modeling study. (2004) (0)
- University of Dundee The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells (2002) (0)
- Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells (2018) (0)
- Involvement of the Adenomatous Polyposis Coli Protein in establishing polar microtubule arrays in the inner ear epithelium. (2002) (0)
- Faculty Opinions recommendation of Mechanical tension can specify axonal fate in hippocampal neurons. (2002) (0)
- Faculty Opinions recommendation of Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. (2003) (0)
- The adenomatous polyposis coli protein 30 years on. (2023) (0)
- Faculty Opinions recommendation of Hsc70 is required for endocytosis and clathrin function in Drosophila. (2002) (0)
- Identification of endogenous Adenomatous polyposis coli interaction partners and β-catenin-independent targets by proteomics (2018) (0)
- A Multicellular Model of Intestinal Crypt Buckling and Fission (2017) (0)
- University of Dundee A Multicellular Model of Intestinal Crypt Buckling and Fission Almet, (2017) (0)
- School of Life Sciences Culture Strategy 2022-2025 (2022) (0)
- 1041 The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial (2002) (0)
- W1940 A Role for the Adenomatous Polposis Coli Protein in Mitotic Spindle Alignment in Gut Epithelium (2009) (0)
- Deep Compressed Sensing for Characterizing Inflammation Severity with Microultrasound (2020) (0)
- Stem cell decisions (2014) (0)
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