Ira Herskowitz

Q: What Schools Are Affiliated With Ira Herskowitz

Ira Herskowitz is affiliated with the following schools: University of California, Berkeley, California Institute of Technology, University of Regensburg, University of Oregon, Stanford University, Massachusetts Institute of Technology, University of California, San Francisco, University of Utah, Harvard University

Ira Herskowitz's AcademicInfluence.com Rankings

Ira Herskowitz

Biology

#916

World Rank

#1602

Historical Rank

#489

USA Rank

Genetics

#157

World Rank

#196

Historical Rank

#92

USA Rank

biology Degrees

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Biology

Ira Herskowitz's Degrees

PhD Biochemistry Stanford University
Bachelors Chemistry University of California, Berkeley

Why Is Ira Herskowitz Influential?

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According to Wikipedia, Ira Herskowitz was an American phage and yeast geneticist who studied genetic regulatory circuits and mechanisms. He was particularly noted for his work on mating type switching and cellular differentiation, largely using Saccharomyces cerevisiae as a model organism.

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Ira Herskowitz's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The transcriptional program of sporulation in budding yeast. (1998) (1984)
Functional inactivation of genes by dominant negative mutations (1987) (1139)
MAP kinase pathways in yeast: For mating and more (1995) (1022)
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals (2002) (821)
Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. (1987) (745)
Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription (1992) (602)
Life cycle of the budding yeast Saccharomyces cerevisiae. (1988) (565)
A regulatory hierarchy for cell specialization in yeast (1989) (553)
Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question (1992) (541)
Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. (1992) (488)
Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle (1994) (485)
Structure of a yeast pheromone gene (MFα): A putative α-factor precursor contains four tandem copies of mature α-factor (1982) (450)
Five SWI genes are required for expression of the HO gene in yeast. (1984) (446)
Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. (1993) (438)
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. (2003) (424)
Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway (1991) (420)
Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast (1997) (414)
The b alleles of U. maydis, whose combinations program pathogenic development, code for polypeptides containing a homeodomain-related motif (1990) (413)
Different a alleles of Ustilago maydis are necessary for maintenance of filamentous growth but not for meiosis. (1989) (409)
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. (1998) (403)
Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2 (1990) (396)
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast (1993) (368)
Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. (1994) (359)
A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development. (1993) (356)
Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. (1998) (349)
Targeting of E. coli β-galactosidase to the nucleus in yeast (1984) (308)
A repressor (MATα2 product) and its operator control expression of a set of cell type specific genes in yeast (1985) (305)
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. (2003) (290)
Identification of an Asymmetrically Localized Determinant, Ash1p, Required for Lineage-Specific Transcription of the Yeast HO Gene (1996) (288)
Yeast go the whole HOG for the hyperosmotic response. (2002) (286)
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 (2003) (285)
The lysis-lysogeny decision of phage lambda: explicit programming and responsiveness. (1980) (283)
Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1. (1994) (272)
Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis. (2003) (270)
Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. (1996) (257)
Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. (1995) (255)
Putting the HO gene to work: practical uses for mating-type switching. (1991) (251)
Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1 (1991) (251)
The a-factor pheromone of Saccharomyces cerevisiae is essential for mating (1988) (244)
A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator (1997) (240)
The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. (1998) (240)
A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci. (1979) (238)
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints (2003) (236)
Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. (1997) (236)
Activation of the yeast HO gene by release from multiple negative controls (1987) (233)
Regulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus. (1983) (228)
Discrete developmental stages during teliospore formation in the corn smut fungus, Ustilago maydis. (1996) (222)
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I (2003) (220)
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor (1986) (211)
Signal transduction during pheromone response in yeast. (1991) (210)
A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains (1992) (208)
Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda. (1984) (206)
Control of cell type in yeast by the mating type locus: The α1-α2 hypothesis☆ (1981) (205)
Interconversion of Yeast Mating Types I. Direct Observations of the Action of the Homothallism (HO) Gene. (1976) (203)
Role of Bud3p in producing the axial budding pattern of yeast (1995) (203)
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. (2002) (196)
11 Mating-type Determination and Mating-type Interconversion in Saccharomyces cerevisiae (1992) (194)
Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription (1991) (193)
Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity. (1997) (191)
Asymmetry and directionality in production of new cell types during clonal growth: the switching pattern of homothallic yeast (1979) (190)
BUD2 encodes a GTPase-activating protein for Budl/Rsrl necessary for proper bud-site selection in yeast (1993) (189)
The yeast SWI4 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cycle-dependent transcription (1989) (189)
Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle. (1994) (188)
Activation of meiosis and sporulation by repression of the RME1 product in yeast (1986) (183)
The BUD4 protein of yeast, required for axial budding, is localized to the mother/BUD neck in a cell cycle-dependent manner (1996) (176)
Escherichia coli Mutants Blocked in Lambda DNA Synthesis (1971) (172)
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. (1993) (168)
Control of Cell Type in Saccharomyces cerevisiae: Mating Type and Mating-type Interconversion (1981) (166)
Control of yeast cell type by the mating type locus. I. Identification and control of expression of the a-specific gene BAR1. (1981) (165)
A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1 (1991) (163)
Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene (1989) (161)
A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1 (1991) (161)
Anatomy and Dynamics of DNA Replication Fork Movement in Yeast Telomeric Regions (2004) (159)
The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs (1990) (157)
Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. (1994) (155)
Post‐transcriptional regulation through the HO 3′‐UTR by Mpt5, a yeast homolog of Pumilio and FBF (2001) (151)
FAR1 is required for oriented polarization of yeast cells in response to mating pheromones (1995) (150)
Induction of Distinct [URE3] Yeast Prion Strains (2001) (149)
Properties of hybrids between Salmonella phage P22 and coliphage λ (1974) (145)
Osmotic Balance Regulates Cell Fusion during Mating in Saccharomyces cerevisiae (1997) (143)
Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion (1979) (142)
A Third Osmosensing Branch in Saccharomyces cerevisiae Requires the Msb2 Protein and Functions in Parallel with the Sho1 Branch (2002) (141)
Control of gene expression in bacteriophage lambda. (1973) (136)
A site essential for expression of all late genes in bacteriophage lambda. (1970) (135)
Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. (1995) (135)
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region (1986) (135)
Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. (1994) (135)
Directionality and regulation of cassette substitution in yeast. (1984) (132)
The Khd1 protein, which has three KH RNA‐binding motifs, is required for proper localization of ASH1 mRNA in yeast (2002) (129)
Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. (1994) (128)
Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. (1991) (121)
Identification of Kel1p, a Kelch Domain-containing Protein Involved in Cell Fusion and Morphology in Saccharomyces cerevisiae (1998) (104)
Control of yeast cell type by the mating type locus: Positive regulation of the α-specific STE3 gene by the MATα 1 product (1983) (100)
Interconversion of Yeast Mating Types II. Restoration of Mating Ability to Sterile Mutants in Homothallic and Heterothallic Strains. (1977) (100)
Interconversion of Yeast Mating Types III. Action of the Homothallism (HO) Gene in Cells Homozygous for the Mating Type Locus. (1977) (100)
Morphological transitions in the life cycle of Ustilago maydis and their genetic control by the a and b loci (1994) (95)
Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding (1996) (91)
Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae (2004) (91)
hflB, a new Escherichia coli locus regulating lysogeny and the level of bacteriophage lambda cII protein. (1986) (90)
Evidence for a new diffusible element of mating pheromones in yeast (1976) (85)
Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae (1984) (83)
The yeast RME1 gene encodes a putative zinc finger protein that is directly repressed by a1-alpha 2. (1991) (81)
Regulation of cell cycle-dependent gene expression in yeast. (1990) (78)
Regulation by the yeast mating-type locus of STE12, a gene required for cell-type-specific expression (1987) (76)
Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site. (1999) (76)
The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain. (1993) (74)
Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. (2003) (72)
O-Glycosylation of Axl2/Bud10p by Pmt4p Is Required for Its Stability, Localization, and Function in Daughter Cells (1999) (71)
STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor. (1988) (64)
rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation (1981) (63)
Mating Pheromones of Saccharomyces kluyveri: Pheromone Interactions Between Saccharomyces kluyveri and Saccharomyces cerevisiae (1979) (62)
Control of Transcription from the r Strand of Bacteriophage Lambda (1970) (62)
Sequences upstream of the STE6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae. (1986) (62)
Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. (1992) (62)
Ash1p is a site-specific DNA-binding protein that actively represses transcription. (2001) (58)
Function-Altering SNPs in the Human Multidrug Transporter Gene ABCB1 Identified Using a Saccharomyces-Based Assay (2007) (57)
The prion domain of yeast Ure2P induces autocatalytic formation of amyloid fibers by a recombinant fusion protein (2008) (55)
Bud morphogenesis and the actin and microtubule cytoskeletons during budding in the corn smut fungus, Ustilago maydis. (2002) (52)
Nuclear Proteins Nut1p and Nut2p Cooperate To Negatively Regulate a Swi4p-Dependent lacZ Reporter Gene inSaccharomyces cerevisiae (1998) (49)
Conservation of a receptor/signal transduction system (1987) (49)
Genes and development: molecular and logical themes. (1990) (44)
Control of yeast cell type by the mating type locus: II. Genetic interactions between MATα and unlinked α-specific STE genes☆ (1981) (44)
Control of cell type in yeast by the mating type locus. The alpha 1-alpha 2 hypothesis. (1981) (44)
Ustilago Maydis, Smut of Maize (1988) (44)
Death-Defying Yeast Identify Novel Apoptosis Genes (1998) (43)
The Cdk-Activating Kinase Cak1p Promotes Meiotic S Phase through Ime2p (2003) (42)
The estimation of polyteny in Drosophila salivary gland nuclei based on determination of desoxyribonucleic acid content. (1952) (41)
The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. (2005) (40)
Rex-dependent exclusion of lambdoid phages. II. Determinants of sensitivity to exclusion. (1980) (40)
Programming of cell polarity in budding yeast by endogenous and exogenous signals. (1995) (40)
Defective prophage in Escherichia coli K12 strains. (1975) (39)
Mutants of bacteriophage λ which do not require the cIII gene for efficient lysogenization (1978) (38)
Identification of polypeptides encoded by an Escherichia coli locus (hflA) that governs the lysis-lysogeny decision of bacteriophage lambda (1987) (37)
Control of yeast cell types by mobile genes: a test. (1979) (37)
Targeting of E. coli beta-galactosidase to the nucleus in yeast. (1984) (35)
The a locus governs cytoduction in Ustilago maydis (1992) (34)
Rex-dependent exclusion of lambdoid phages. I. Prophage requirements for exclusion. (1980) (33)
Escherichia coli nusB mutations that suppress nusA1 exhibit λ N specificity (1983) (33)
Cell polarity protein Spa2P associates with proteins involved in actin function in Saccharomyces cerevisiae. (2005) (33)
36 Integration of Multiple Regulatory Inputs in the Control of HO Expression in Yeast (1992) (31)
Control of yeast cell type by the mating type locus: positive regulation of the alpha-specific STE3 gene by the MAT alpha 1 product. (1983) (30)
The ins and outs of cell-polarity decisions (2000) (29)
The role of gene cro in phage development. (1975) (29)
CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. (1990) (29)
Rex-dependent exclusion of lambdoid phages. III. Physiology of the abortive infection. (1980) (27)
Genetic and biochemical characterization of the yeast spo12 protein. (1999) (27)
Interactions of Bacteriophage and Host Macromolecules in the Growth of Bacteriophage X (27)
XV. Yeast sequencing reports. Isolation and DNA sequence of the STE13 gene encoding dipeptidyl aminopeptidase (1994) (26)
Master regulatory loci in yeast and lambda. (1985) (25)
Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast. (1992) (24)
Healing of mat mutations and control of mating type interconversion by the mating type locus in Saccharomyces cerevisiae. (1979) (24)
Homology and non-homology at the yeast mating type locus (1981) (24)
The protein kinase Pho85 is required for asymmetric accumulation of the Ash1 protein in Saccharomyces cerevisiae (2001) (23)
STE16, a new gene required for pheromone production by a cells of Saccharomyces cerevisiae. (1987) (23)
Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computational genomic analysis (2005) (23)
Substitution mutations in bacteriophage λ with new specificity for late gene expression (1974) (22)
Pattern of switching and fate of the replaced cassette in yeast mating-type interconversion. (1981) (22)
Polarity suppression by the Q gene product of bacteriophage lambda. (1982) (21)
From membrane to nucleus: the pathway of signal transduction in yeast and its genetic control. (1988) (20)
Yeast branches out (1992) (17)
SAD mutation of Saccharomyces cerevisiae is an extra a cassette (1983) (17)
Cell biology: Yeast as the universal cell (1985) (15)
Location of the regulatory site for establishment of repression by bacteriophage lambda. (1979) (15)
Cellular differentiation, cell lineages, and transposable genetic cassettes in yeast. (1983) (14)
Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity (1996) (11)
The Hawthorne deletion twenty-five years later. (1988) (11)
Building organs and organisms: elements of morphogenesis exhibited by budding yeast. (1997) (10)
A master regulatory locus that determines cell specialization in yeast. (1985) (10)
PharmGKB Submission Update: V. PMT Submissions of Genetic Variation in SLC22 Family Transporters (2006) (10)
Control of late genes, early genes, the cI gene, and replication in bacteriophage [lambda] (1971) (8)
MUTATIONS OF THE HMa AND HMα LOCI AND THEIR BEARING ON THE CASSETTE MODEL OF MATING TYPE INTERCONVERSION IN YEAST (1979) (8)
Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda (1984) (8)
PharmGKB Update: I. Genetic Variants of the Organic Cation Transporter 2 (OCT2, SLC22A2) (2003) (8)
Negative Regulation of STE6 Gene Expression by the cx2 Product of Saccharomyces cerevisiae (7)
PharmGKB Update: III. Genetic Variants of SLC22A1, Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (2004) (5)
Phosphorylation of FAR 1 in Response to a-Factor : A Possible Requirement for Cell-Cycle Arrest (5)
PharmGKB Submission Update: VI. PMT Submissions of Genetic Variations in Neurotransmitter Transporters (SLC6, SLC17, and SLC18) to the PharmGKB Network (2006) (4)
CONTROL OF CELL TYPE IN YEAST BY GENETIC CASSETTES (1980) (4)
SNP Analysis and Presentation in the Pharmacogenetics of Membrane Transporters Project (2002) (4)
Anecdotal, Historical and Critical Commentaries on Genetics (2004) (3)
Fungal physiology. Yeast branches out. (1992) (3)
Genetic and Biochemical Characterization of the Yeast Spo 12 Protein (1999) (3)
Regulators of synthesis and activity of the G1 cyclins of budding yeast. (1991) (3)
Learning about cancer genes through invertebrate genetics. (1992) (3)
A dominant mutation (SAD) bypassing the requirement for the a mating type locus in yeast sporulation (1980) (3)
Double Talking Helix Blues (1993) (3)
The 2001 Thomas Hunt Morgan Medal. Yasuji Oshima. (2002) (3)
Learning about cancer genes through invertebrate genetics (1992) (3)
Genetic Analysis of Cisplatin Resistance in Yeast and Mammals (2007) (3)
Coming early to the late genes (1998) (2)
Pathogenicity determinants in the smut fungi of cereals (1992) (2)
Mutants of bacteriophage lambda which do not requre the cIII gene for efficient lysogenization. (1978) (2)
The trans action of HMRa in mating type interconversion (2004) (2)
Regulating natural health products. (2002) (1)
Substitution mutation in bacteriophage lambda with new specificity for late gene expression. (1974) (1)
Reconstitution of a yeast protein kinase cascade in vitro : Activation of the yeast MEK homologue STE 7 by STEll ( mating response / mto-tivatd protein kine / MEK knase / Saccharomyces cerevisiae ) (1)
Hospital merger leaves clinical science intact (1999) (1)
Control of yeast cell type by the mating type locus. II. Genetic interactions between MAT alpha and unlinked alpha-specific STE genes. (1981) (1)
Political Discussions at Gordon Conference (1971) (0)
Letter from Ira Herskowitz to Joshua Lederberg (1995) (0)
Editorial Board (1995) (0)
Book Review:Control Processes in Virus Multiplication. D. C. Burke, W. C. Russell (1976) (0)
Editorial Board (1995) (0)
Editorial Board (1995) (0)
Mutations of the hma and hm alpha loci and their bearing on the cassette model of mating type inter conversion in yeast saccharomyces cerevisiae (1980) (0)
Polarization in Saccharomyces cerevisiae (1994) (0)
Death-Defying Yeast Identify Minireview Novel Apoptosis Genes (1998) (0)
Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins (1987) (0)
Genome rearrangement: Proceedings of the UCLA symposium held at Steamboat Springs, Colorado, April 7-13, 1984 (1985) (0)
Political discussions at gordon conference. (1971) (0)
Location of the regulatory site for establishment of repression by bacteriophage X ( bacteriophage X cI gene / RNA regulation / new initiation vs . antitermination of RNA ) (0)
INTERCONVERSION OF YEAST MATING TYPES 111. ACTION OF THE HOMOTHALLISM ( H O ) GENE IN CELLS (2003) (0)
Sequences upstream of the STE 6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae ( cell specialization / transcriptional repression / regulatory sites ) (2003) (0)

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