Ira Pastan
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American scientist
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Ira Pastanbiology Degrees
Biology
#429
World Rank
#772
Historical Rank
#257
USA Rank
Molecular Biology
#48
World Rank
#49
Historical Rank
#33
USA Rank
Biochemistry
#39
World Rank
#53
Historical Rank
#26
USA Rank
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Biology
Ira Pastan's Degrees
- PhD Biochemistry University of California, Berkeley
Why Is Ira Pastan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ira Pastan is an American scientist at the National Cancer Institute. He is a member of the National Academy of Sciences, a Fellow of the AAAS and the American Society of Microbiology. In 2009, he was awarded the prestigious International Antonio Feltrinelli Prize for Medicine. His wife, Linda Pastan, was an American poet.
Ira Pastan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biochemistry of multidrug resistance mediated by the multidrug transporter. (1993) (3560)
- Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. (1987) (2758)
- Biochemical, cellular, and pharmacological aspects of the multidrug transporter. (1999) (2065)
- Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells (1986) (1841)
- Expression of a multidrug-resistance gene in human tumors and tissues. (1987) (1529)
- Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. (1987) (1066)
- The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. (1982) (1005)
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains (2009) (772)
- Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. (1992) (766)
- Multiple-drug resistance in human cancer. (1987) (706)
- The multidrug transporter, a double-edged sword. (1988) (673)
- Expression of the Multidrug Resistance Gene in Human Cancer (1991) (672)
- Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. (1986) (668)
- Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. (1996) (644)
- Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. (1980) (641)
- Role of cyclic nucleotides in growth control. (1975) (637)
- Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. (1989) (611)
- Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. (1986) (567)
- Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. (1987) (522)
- Isolation and genetic characterization of human KB cell lines resistant to multiple drugs (1985) (521)
- Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. (1978) (521)
- Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. (1992) (505)
- Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. (2001) (504)
- Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones (1980) (497)
- HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. (1998) (495)
- Genetic analysis of the multidrug transporter. (1995) (487)
- Fluorescent cellular indicators are extruded by the multidrug resistance protein. (1993) (483)
- Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. (2013) (466)
- Identification of two lysosomal membrane glycoproteins (1985) (461)
- A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. (1988) (460)
- Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. (1976) (458)
- Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. (1986) (455)
- Journey to the center of the cell: role of the receptosome. (1981) (455)
- Cyclic Adenosine Monophosphate in Bacteria (1970) (435)
- Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. (1985) (434)
- ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. (1988) (426)
- Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. (2000) (425)
- The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. (1986) (417)
- Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli (1987) (413)
- Mesothelin: a new target for immunotherapy. (2004) (404)
- Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. (1987) (400)
- Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth. (1971) (400)
- A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin (1989) (395)
- Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. (1971) (383)
- Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. (1990) (382)
- Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. (1984) (379)
- High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines. (1986) (372)
- Clathrin-coated vesicles: Isolation, dissociation and factor-dependent reassociation of clathrin baskets (1979) (369)
- The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. (1987) (367)
- Immunotoxin treatment of cancer. (2007) (367)
- Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry (1980) (366)
- Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. (1992) (358)
- Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. (1990) (353)
- P-glycoprotein and multidrug resistance. (1996) (352)
- Phase I Study of SS1P, a Recombinant Anti-Mesothelin Immunotoxin Given as a Bolus I.V. Infusion to Patients with Mesothelin-Expressing Mesothelioma, Ovarian, and Pancreatic Cancers (2007) (351)
- The receptosome: An intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts (1980) (348)
- A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies. (1992) (344)
- Receptor-mediated endocytosis of hormones in cultured cells. (1981) (344)
- A Key Role of Starburst Amacrine Cells in Originating Retinal Directional Selectivity and Optokinetic Eye Movement (2001) (338)
- Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors (2006) (334)
- Collection of insulin, EGF and α 2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization (1978) (330)
- Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. (1997) (328)
- Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. (1977) (327)
- Recombinant toxins as novel therapeutic agents. (1992) (320)
- Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs. (1986) (316)
- Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling. (1986) (312)
- Inhibition of VSV binding and infectivity by phosphatidylserine: Is phosphatidylserine a VSV-binding site? (1983) (308)
- Recombinant toxins for cancer treatment. (1991) (308)
- alpha-Galactosidase A deficient mice: a model of Fabry disease. (1997) (292)
- Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. (1970) (288)
- Cyclic adenosine 5'-monophosphate in Escherichia coli. (1976) (288)
- Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells (1984) (287)
- Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. (2012) (283)
- Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene. (1985) (276)
- Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. (1987) (275)
- Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes. (1984) (275)
- Improving antibody affinity by mimicking somatic hypermutation in vitro (1999) (263)
- Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies. (2005) (263)
- Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5'-monophosphate levels in fibroblasts. (1972) (263)
- Detection and Quantitation of Serum Mesothelin, a Tumor Marker for Patients with Mesothelioma and Ovarian Cancer (2006) (262)
- Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. (1987) (259)
- Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. (1990) (257)
- ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. (1970) (251)
- Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation (1977) (250)
- Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. (1998) (248)
- Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis (1983) (245)
- Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity. (1990) (241)
- Epidermal growth factor regulates the expression of its own receptor. (1985) (241)
- Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. (2005) (240)
- Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin Termed PE-38 (TP-38) for the Treatment of Malignant Brain Tumors (2003) (240)
- Molecular cloning and characterization of a human DNA binding factor that represses transcription (1989) (234)
- Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium (1992) (233)
- Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi (1983) (231)
- Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells. (1986) (229)
- Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. (1984) (229)
- Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma. (2000) (228)
- Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin. (1995) (228)
- Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene. (1987) (226)
- Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry (1979) (226)
- Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts (1977) (226)
- Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein (1988) (223)
- A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer (2011) (221)
- Transfer and expression of the human multiple drug resistance gene into live mice. (1992) (220)
- Liver angiotensinogen is the primary source of renal angiotensin II. (2012) (220)
- Treatment of advanced solid tumors with immunotoxin LMB–1: An antibody linked to Pseudomonas exotoxin (1996) (213)
- Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol. (1990) (211)
- Mesothelin Immunotherapy for Cancer: Ready for Prime Time? (2016) (211)
- A Novel Chimeric Protein Composed of Interleukin 13 and Pseudomonas Exotoxin Is Highly Cytotoxic to Human Carcinoma Cells Expressing Receptors for Interleukin 13 and Interleukin 4 (*) (1995) (211)
- Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression (2013) (210)
- A recombinant immunotoxin containing a disulfide-stabilized Fv fragment. (1993) (209)
- Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P (2009) (208)
- Mesothelin Is Not Required for Normal Mouse Development or Reproduction (2000) (207)
- Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface (1979) (206)
- Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog. (1988) (204)
- B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice. (1991) (204)
- Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. (2000) (204)
- Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. (2009) (203)
- Immunotoxins in cancer therapy. (1999) (203)
- Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. (1998) (200)
- Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. (1977) (199)
- Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination (1998) (196)
- Characterization of the azidopine and vinblastine binding site of P-glycoprotein. (1992) (195)
- Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription. (1971) (195)
- Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL. (1991) (193)
- The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. (1975) (190)
- Discovery of mesothelin and exploiting it as a target for immunotherapy. (2014) (189)
- Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. (2008) (188)
- Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. (1989) (188)
- Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (2011) (187)
- MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia (1990) (187)
- MRP8, A New Member of ABC Transporter Superfamily, Identified by EST Database Mining and Gene Prediction Program, Is Highly Expressed in Breast Cancer (2001) (187)
- alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions (1979) (184)
- Clinical trials of agents that reverse multidrug-resistance. (1989) (184)
- Function and regulation of the human multidrug resistance gene. (1993) (182)
- Phase I Clinical Trial of the Chimeric Anti-Mesothelin Monoclonal Antibody MORAb-009 in Patients with Mesothelin-Expressing Cancers (2010) (182)
- Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells. (1984) (182)
- Purification of and Properties of the Cyclic Adenosine 3',5'-Monophosphate Receptor Protein which Mediates Cyclic Adenosine 3',5'-Monophosphate-dependent Gene Transcription in Escherichia coli (1971) (180)
- An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes (2008) (179)
- Immunotoxin therapy of cancer (2006) (179)
- Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells (1985) (177)
- Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3. (1993) (177)
- Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes (1984) (177)
- Vinculin, a cytoskeletal substrate of protein kinase C. (1983) (177)
- Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter. (1985) (176)
- Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. (2007) (176)
- Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (1995) (176)
- Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo1 (2007) (174)
- The collagen gene: Evidence for its evolutionary assembly by amplification of a DNA segment containing an exon of 54 bp (1980) (172)
- Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. (1985) (172)
- Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells (*) (1996) (172)
- Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells. (1990) (172)
- P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. (1989) (172)
- ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells (1987) (170)
- Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin. (1989) (169)
- MDR1 gene expression in lung cancer. (1989) (168)
- Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli. (1969) (167)
- Responses in refractory hairy cell leukemia to a recombinant immunotoxin. (1999) (167)
- Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. (2000) (164)
- Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin. (1982) (161)
- Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. (2006) (160)
- Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia (1989) (158)
- Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine. (1989) (158)
- Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis. (1998) (157)
- Localization of Mesothelin in Epithelial Ovarian Cancer (2005) (157)
- Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. (2002) (157)
- Targeted toxin therapy for the treatment of cancer. (1989) (156)
- Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia (2018) (156)
- Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance. (1991) (156)
- The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum. (1987) (155)
- Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain. (1993) (155)
- The visualization of fluorescent proteins in living cells by video intensification microscopy (VIM) (1978) (154)
- "Big insulin": a new component of plasma insulin detected by immunoassay. (1968) (153)
- Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene (1986) (153)
- Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells. (1987) (152)
- Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine (2003) (152)
- Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells. (1990) (152)
- Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor. (1995) (152)
- Monoclonal Antibody K1 Reacts With Epithelial Mesothelioma but not With Lung Adenocarcinoma (1992) (151)
- Advances in anticancer immunotoxin therapy. (2015) (151)
- Distinct Roles of Segregated Transmission of the Septo-Habenular Pathway in Anxiety and Fear (2013) (151)
- Regulation of Cell Motility by Cyclic AMP (1972) (151)
- A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. (2009) (150)
- Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1&agr;-secreting Glioblastoma (2015) (150)
- Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. (1992) (150)
- BINDING OF HORMONE TO TISSUE: THE FIRST STEP IN POLYPEPTIDE HORMONE ACTION (1966) (150)
- Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol. (1992) (149)
- Cyclic AMP regulates Catabolite and Transient Repression in E. coli (1969) (148)
- Humoral Immune Response to Mesothelin in Mesothelioma and Ovarian Cancer Patients (2005) (148)
- Characterization of a major fibroblast cell surface glycoprotein. (1977) (148)
- P-glycoproteins: mediators of multidrug resistance. (1993) (146)
- Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. (2014) (145)
- Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors. (1985) (145)
- A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses (2007) (145)
- A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. (1987) (145)
- Resistance to multiple chemotherapeutic agents in human cancer cells. (1988) (145)
- Nuclear factor ETF specifically stimulates transcription from promoters without a TATA box. (1989) (145)
- Multidrug resistance in human cancer. (1992) (145)
- Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma (1970) (144)
- Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front‐line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125 (2014) (143)
- Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin. (1987) (142)
- Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes (2012) (142)
- A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins. (1990) (141)
- Hyperproduction and gene amplification of the epidermal growth factor receptor in squamous cell carcinomas. (1985) (141)
- INTRACEREBRAL INFUSATE DISTRIBUTION BY CONVECTION‐ENHANCED DELIVERY IN HUMANS WITH MALIGNANT GLIOMAS: DESCRIPTIVE EFFECTS OF TARGET ANATOMY AND CATHETER POSITIONING (2007) (141)
- Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments (1996) (141)
- Anti-CD22 Immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-Positive Hematologic Malignancies of Childhood: Preclinical Studies and Phase I Clinical Trial (2010) (140)
- Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy. (1999) (139)
- Both ATP sites of human P-glycoprotein are essential but not symmetric. (1999) (139)
- Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display. (1996) (137)
- Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas. (1991) (137)
- Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies. (1994) (137)
- Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium. (1992) (136)
- Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. (1999) (136)
- Effects of Calcium on ACTH Stimulation of the Adrenal: Separation of Hormone Binding from Adenyl Cyclase Activation (1970) (135)
- 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors. (2016) (135)
- Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain. (1988) (134)
- Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance. (1988) (133)
- Cyclic 3'5-AMP: stimulation of beta-galactosidase and tryptophanase induction in E. coli. (1968) (133)
- Laboratory and clinical evaluation of conjugate vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides bound to Pseudomonas aeruginosa recombinant exoprotein A (1993) (132)
- Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. (1969) (132)
- Transit of epidermal growth factor through coated pits of the Golgi system (1982) (131)
- TRANSFORMATION‐SENSITIVE CELL SURFACE PROTEIN: ISOLATION, CHARACTERIZATION, AND ROLE IN CELLULAR MORPHOLOGY AND ADHESION (1978) (131)
- Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions. (1994) (129)
- Cellular transformation and the ‘morphologic phenotype’ of transformed cells (1978) (128)
- Regulation of beta-galactosidase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate. (1968) (128)
- Purification and properties of filamin, and actin binding protein from chicken gizzard. (1976) (127)
- Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines. (1990) (126)
- Mesothelin Expression in Human Lung Cancer (2007) (126)
- Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10−15 M (2001) (125)
- Effect of Rho on transcription of bacterial operons. (1973) (125)
- Expression of the multidrug resistance, MDR1, gene in neuroblastomas. (1990) (124)
- The Pathway of Endocytosis (1985) (124)
- The Role of Cyclic AMP in Bacteria (1971) (124)
- Human neurological cancer cells express interleukin‐4 (IL‐4) receptors which are targets for the toxic effects of IL4‐pseudomonas exotoxin chimeric protein (1994) (124)
- Characterization of CD22 expression in acute lymphoblastic leukemia (2015) (124)
- Expression of a human multidrug resistance gene in ovarian carcinomas. (1989) (124)
- Unusual methylation pattern of the α2(I) collagen gene (1982) (123)
- Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma (2012) (123)
- A mutation in a rous sarcoma virus gene that controls adenosine 3',5'-monophosphate levels and transformation. (1972) (121)
- Immunotoxins against cancer. (1994) (120)
- Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. (1988) (120)
- Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. (1978) (119)
- Cyclic amp and cell morphology in cultured fibroblasts. Effects on cell shape, microfilament and microtubule distribution, and orientation to substratum (1975) (119)
- MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants. (1989) (118)
- Pseudomonas exotoxin: chimeric toxins. (1989) (118)
- The effect of growth conditions on NAD+ and NADH concentrations and the NAD+:NADH ratio in normal and transformed fibroblasts. (1974) (118)
- N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells. (1972) (117)
- Mechanism of Action of Human P-glycoprotein ATPase Activity (1998) (117)
- Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites. (1988) (117)
- The multichain interleukin-2 receptor: a target for immunotherapy. (1988) (117)
- MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer (2002) (117)
- Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. (2011) (116)
- Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. (1996) (116)
- Expression of the multidrug resistance gene in myeloid leukemias. (1990) (115)
- Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. (1980) (115)
- Vinculin phosphorylation in response to calcium and phorbol esters in intact cells. (1984) (115)
- Genetic basis of multidrug resistance of tumor cells (1990) (114)
- Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR). (1996) (114)
- Binding of the Sp1 transcription factor by the human Harvey ras1 proto-oncogene promoter. (1986) (114)
- Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions. (2007) (114)
- Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. (1997) (114)
- pH-dependent lysis of liposomes by adenovirus. (1986) (113)
- Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. (2008) (112)
- Immunotoxins for leukemia. (2014) (112)
- Cyclic AMP and the transformation of fibroblasts. (1974) (112)
- Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus (1980) (112)
- Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor. (1988) (111)
- The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (1996) (111)
- Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor. (1999) (111)
- Control of DNA synthesis and mitosis in 3T3 cells by cyclic AMP. (1972) (110)
- Megakaryocyte Potentiation Factor Cleaved from Mesothelin Precursor Is a Useful Tumor Marker in the Serum of Patients with Mesothelioma (2006) (109)
- Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv. (1994) (109)
- Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells. (1981) (109)
- Stimulation of guanylate cyclase of fibroblasts by free fatty acids. (1976) (109)
- Studies of pathways of glucose metabolism of endocrine tissues. (1960) (108)
- Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates. (1994) (108)
- Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 ). (1972) (108)
- Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients1 (2006) (107)
- Expression of the human multidrug transporter in insect cells by a recombinant baculovirus. (1990) (107)
- New Immunotoxins Targeting CD123, a Stem Cell Antigen on Acute Myeloid Leukemia Cells (2007) (107)
- Activation of adenyl cyclase in thyroid homogenates by thyroid-stimulating hormone. (1967) (107)
- A circularly permuted recombinant interleukin 4 toxin with increased activity. (1994) (107)
- Evidence for participation of transglutaminase in receptor-mediated endocytosis. (1980) (107)
- Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma (1994) (106)
- Decreased accumulation of [14c]carboplatin in human cisplatin‐resistant cells results from reduced energy‐dependent uptake (2000) (106)
- Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia. (1994) (106)
- Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins. (1998) (105)
- Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters. (1995) (105)
- Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis. (1998) (105)
- Impairment of reward-related learning by cholinergic cell ablation in the striatum (2003) (103)
- Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters. (1992) (102)
- Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (1999) (102)
- The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene. (2015) (102)
- Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes (2011) (102)
- Identification of a Set of Seven Genes for the Monitoring of Minimal Residual Disease in Pediatric Acute Myeloid Leukemia (2006) (102)
- Filamin-actin interaction. Dissociation of binding from gelation by Ca2+-activated proteolysis. (1978) (102)
- Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART (2014) (102)
- Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli. (1988) (102)
- Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway. (2006) (101)
- Role of 3',5'-adenosine monophosphate in regulation of morphology and growth of transformed and normal fibroblasts. (1972) (101)
- Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation (1976) (101)
- In Vitro Antibody Evolution Targeting Germline Hot Spots to Increase Activity of an Anti-CD22 Immunotoxin* (2005) (101)
- Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses. (1998) (100)
- Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens (2001) (100)
- Podocyte injury damages other podocytes. (2011) (100)
- Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA. (1997) (99)
- Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor (1984) (98)
- Immunotoxin therapy of cancer. (1993) (98)
- Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye. (1990) (97)
- Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes (2014) (97)
- CAT-8015: A Second-Generation Pseudomonas Exotoxin A–Based Immunotherapy Targeting CD22-Expressing Hematologic Malignancies (2009) (97)
- Adenyl cyclase in normal and transformed fibroblasts in tissue culture. Activation by prostaglandins. (1971) (97)
- Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis. (1983) (97)
- Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. (1998) (97)
- alpha 2-macroglobulin adsorbed to colloidal gold: a new probe in the study of receptor-mediated endocytosis (1981) (97)
- Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy. (1998) (97)
- Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. (1985) (97)
- Recombinant immunotoxins for treating cancer. (2004) (96)
- Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias. (2000) (96)
- Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment. (1994) (96)
- Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice. (1992) (96)
- Mesothelin-Targeted Agents in Clinical Trials and in Preclinical Development (2012) (95)
- PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. (1998) (94)
- Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts. (1975) (94)
- Immunotoxins containing Pseudomonas exotoxin A: a short history (2003) (94)
- Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats (2009) (94)
- Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis. (1996) (93)
- Endocytosis and exocytosis: current concepts of vesicle traffic in animal cells. (1984) (93)
- Role of caspases in immunotoxin-induced apoptosis of cancer cells. (1998) (93)
- Effect of ABC transporters on HIV‐1 infection: inhibition of virus production by the MDR1 transporter (2000) (93)
- Saturable binding sites for vesicular stomatitis virus on the surface of Vero cells (1982) (93)
- Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. (1994) (92)
- Removing T-cell epitopes with computational protein design (2014) (92)
- Stimulation in vitro of pathways of glucose oxidation in thyroid by thyroid-stimulating hormone. (1960) (92)
- Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity. (1991) (92)
- Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin. (1994) (91)
- A simple method for in vitro metabolic studies using small volumes of tissue and medium. (1963) (91)
- Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor. (1969) (91)
- The effect of dibutyryl cyclic adenosine monophosphate on synthesis of sulfated acid mucopolysaccharides by transformed fibroblasts. (1972) (90)
- A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity (2012) (90)
- Cyclic AMP increases the Adhesion of Fibroblasts to Substratum (1972) (90)
- Localization of multidrug resistance-associated DNA sequences to human chromosome 7 (1986) (89)
- Immunogenicity of therapeutic recombinant immunotoxins (2016) (89)
- Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components. (1977) (89)
- Change in growth and morphology of fibroblasts by prostaglandins. (1971) (88)
- Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein. (1989) (88)
- ACTH‐RECEPTOR INTERACTION IN THE ADRENAL: A MODEL FOR THE INITIAL STEP IN THE ACTION OF HORMONES THAT STIMULATE ADENYL CYCLASE (1971) (87)
- In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer (2014) (87)
- Regulation of lac mRNA synthesis in a soluble cell-free system. (1971) (87)
- Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. (1996) (87)
- Complete regression of human B‐cell lymphoma xenografts in mice treated with recombinant anti‐CD22 immunotoxin RFB4(dsFv)‐PE38 at doses tolerated by cynomolgus monkeys (1999) (86)
- Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer. (1990) (86)
- Recombinant immunotoxins in the treatment of cancer. (2004) (86)
- Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein. (1997) (86)
- Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells. (1994) (86)
- Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles. (1991) (85)
- The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling. (1983) (85)
- Retroviral coexpression of a multidrug resistance gene (MDR1) and human alpha-galactosidase A for gene therapy of Fabry disease. (1995) (85)
- Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells (1976) (84)
- Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. (1995) (84)
- Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line. (1985) (84)
- Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. (2000) (84)
- Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines. (1985) (83)
- Anti-Tac(Fv)-PE40, a single chain antibody Pseudomonas fusion protein directed at interleukin 2 receptor bearing cells. (1990) (83)
- Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma. (1995) (83)
- Regulation of the multidrug resistance gene in regenerating rat liver. (1990) (83)
- Binding and internalization of 125I-alpha 2-macroglobulin by cultured fibroblasts. (1981) (83)
- Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors (2007) (83)
- Renaturation of a Single–Chain Immunotoxin Facilitated by Chaperones and Protein Disulfide Isomerase (1992) (83)
- A transcription factor active on the epidermal growth factor receptor gene. (1988) (82)
- Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections. (1992) (82)
- Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor. (1984) (82)
- In vitro transcription of the gal operon requires cyclic adenosine monophosphate and cyclic adenosine monophosphate receptor protein. (1971) (82)
- Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A (2012) (81)
- Characterization of immunotoxins active against ovarian cancer cell lines. (1985) (81)
- POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer (2002) (81)
- XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (2000) (81)
- Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA. (1981) (80)
- The morphologic pathway of exocytosis of the vesicular stomatitis virus G protein in cultured fibroblasts (1982) (80)
- Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant. (1977) (80)
- NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. (2004) (80)
- Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII‐specific scFv (2000) (80)
- HA22 (R490A) Is a Recombinant Immunotoxin with Increased Antitumor Activity without an Increase in Animal Toxicity (2005) (80)
- Synergistic Antitumor Activity of Taxol and Immunotoxin SS1P in Tumor-Bearing Mice (2006) (80)
- Localization of serum-derived α2 macroglobulin in cultured cells and decrease after moloney sarcoma virus transformation (1977) (80)
- Efficient Expression of Drug-selectable Genes in Retroviral Vectors Under Control of an Internal Ribosome Entry Site (1994) (80)
- Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds. (1993) (79)
- Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. (2005) (79)
- TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus. (2000) (79)
- Adenovirus-dependent release of 51Cr from KB cells at an acidic pH. (1984) (78)
- Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro. (2002) (78)
- Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies (2000) (78)
- Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. (2009) (78)
- Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation. (1996) (78)
- Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene. (1989) (78)
- Effect of liposomes containing cholesterol on adenylate cyclase activity of cultured mammalian fibroblasts. (1978) (77)
- Human CTLs to Wild-Type and Enhanced Epitopes of a Novel Prostate and Breast Tumor-Associated Protein, TARP, Lyse Human Breast Cancer Cells (2004) (77)
- The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. (1990) (77)
- Purification of mammalian filamin. Similarity to high molecular weight actin-binding protein in macrophages, platelets, fibroblasts, and other tissues. (1978) (77)
- Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors. (1995) (76)
- Targeted therapy of cancer with recombinant immunotoxins. (1997) (76)
- Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv) (1991) (76)
- Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells. (1988) (76)
- Isolation and characterization of myosin from cloned mouse fibroblasts. (1972) (76)
- Receptor-mediated endocytosis in cultured fibroblasts: cryptic coated pits and the formation of receptosomes. (1981) (75)
- Cyclic AMP in Metobolism (1971) (75)
- Selective Elimination of Human Regulatory T Lymphocytes In Vitro With the Recombinant Immunotoxin LMB-2 (2006) (75)
- Pulsed High-Intensity Focused Ultrasound Enhances Uptake of Radiolabeled Monoclonal Antibody to Human Epidermoid Tumor in Nude Mice (2008) (75)
- Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab' induce regression of subcutaneous human B-cell lymphoma in mice. (1993) (75)
- Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice. (1995) (75)
- Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. (2007) (75)
- Stimulation of tryptophanase synthesis in Escherichia coli by cyclic 3',5'-adenosine monophosphate. (1969) (75)
- Conditional Ablation of Striatal Neuronal Types Containing Dopamine D2 Receptor Disturbs Coordination of Basal Ganglia Function (2003) (75)
- Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1 (2010) (74)
- A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin. (1990) (74)
- Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump. (1990) (74)
- Immunotoxins in the treatment of hematologic malignancies. (2006) (74)
- Recombinant anti‐podoplanin (NZ‐1) immunotoxin for the treatment of malignant brain tumors (2013) (74)
- Targeting malignant B cells with an immunotoxin against ROR1 (2012) (74)
- Anti-Tumor Activity of K1-LysPE38QQR, an Immunotoxin Targeting Mesothelin, a Cell-Surface Antigen Overexpressed in Ovarian Cancer and Malignant Mesothelioma (2000) (73)
- Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus. (1983) (73)
- A model for obesity and gigantism due to disruption of the Ankrd26 gene (2008) (73)
- Vinculin phosphorylation by the src kinase. Interaction of vinculin with phospholipid vesicles. (1983) (73)
- Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. (1994) (72)
- Transforming Growth Factor-α—Pseudomonas Exotoxin Fusion Protein (TGF-α-PE38) Treatment of Subcutaneous and Intracranial Human Glioma and Medulloblastoma Xenografts in Athymic Mice (1994) (72)
- Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts. (1990) (72)
- Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein. (1998) (72)
- Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors. (1990) (72)
- New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA (2005) (72)
- Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines (1977) (71)
- Studies on the levels of cyclic AMP in cells transformed by wild-type and temperature-sensitive Kirsten sarcoma virus (1974) (71)
- Cytotoxic activities of a fusion protein comprised of TGFα and Pseudomonas exotoxin (1989) (71)
- A monoclonal antibody that precipitates the glycoprotein receptor for epidermal growth factor is directed against the human blood group H type 1 antigen. (1983) (71)
- Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice. (1990) (71)
- Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor‐targeted therapy (1997) (71)
- Segregation and Coactivation of Developing Neocortical Layer 1 Neurons (2003) (71)
- Molecular properties of a major cell surface protein from chick embryo fibroblasts. (1978) (71)
- Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. (1992) (70)
- Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate (1984) (70)
- Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. (2008) (70)
- Domain II mutants of Pseudomonas exotoxin deficient in translocation. (1989) (70)
- Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins. (2004) (70)
- Myosin is a component of the cell surface of cultured cells. (1974) (70)
- Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. (1979) (70)
- An Atlas of Immunofluorescence in Cultured Cells (1985) (70)
- Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin. (1991) (70)
- High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis (2015) (69)
- Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. (2008) (69)
- Cyclic AMP-dependent phosphorylation of filamin in mammalian smooth muscle. (1978) (69)
- Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts. (1979) (69)
- Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin. (1989) (69)
- Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity. (2001) (69)
- Cytotoxicity of the anti‐CD22 immunotoxin HA22 (CAT‐8015) against paediatric acute lymphoblastic leukaemia (2010) (69)
- Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins. (1976) (68)
- Frequent expression of the tumor antigen cak1 in squamous‐cell carcinomas (1992) (68)
- Intracellular localization of actin in cultured fibroblasts by electron microscopic immunocytochemistry. (1981) (68)
- Effects of phosphorylation of P-glycoprotein on multidrug resistance (1995) (68)
- Repression of beta-galactosidase synthesis by glucose in phosphotransferase mutants of Escherichia coli. Repression in the absence of glucose phosphorylation. (1969) (68)
- Cytotoxic Effects of a Recombinant Chimeric Toxin on Rapidly Proliferating Vascular Smooth Muscle Cells (1991) (68)
- A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin. (1993) (68)
- Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines. (1996) (67)
- Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin. (1997) (67)
- Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells. (1997) (67)
- Isolation of genomic DNA clones spanning the entire fibronectin gene. (1983) (67)
- Ultrastructural antibody localization of alpha2-macroglobulin in membrane-limited vesicles in cultured cells. (1978) (67)
- Expression of a multidrug resistance-adenosine deaminase fusion gene. (1989) (67)
- Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity. (1973) (66)
- Cyclic adenosine monophosphate receptor: loss of cAMP-dependent DNA binding activity after proteolysis in the presence of cyclic adenosine monophosphate. (1973) (66)
- Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy. (2010) (66)
- L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment. (1996) (66)
- Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases. (2004) (66)
- The effect of dibutyryl cyclic 3',5'-AMP on the thyroid. (1966) (66)
- Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP (1980) (66)
- Properties of the src kinase purified from Rous sarcoma virus-induced rat tumors. (1982) (65)
- Immunotoxins (1986) (65)
- Inhibitors of 125I-epidermal growth factor internalization. (1980) (65)
- Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin (2005) (65)
- POTE paralogs are induced and differentially expressed in many cancers. (2006) (65)
- Inhibition of the nuclear entry of 3,3',5'-triiodo-L-thyronine by monodansylcadaverine in GH3 cells. (1982) (64)
- Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model. (1987) (64)
- Interferon and cyclic-3'5'-adenosine monophosphate: potentiation of antiviral activity. (1969) (64)
- Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome. (1995) (64)
- The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle. (1996) (64)
- High Expression of a Specific T-Cell Receptor γ Transcript in Epithelial Cells of the Prostate (1999) (64)
- Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1. (1999) (64)
- Activation of transcription at specific promoters by glycerol. (1974) (64)
- Binding of adenovirus and its external proteins to Triton X-114. Dependence on pH. (1985) (63)
- Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40). (1991) (63)
- Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy (2013) (63)
- Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors. (2012) (63)
- Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity. (1988) (63)
- Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor (1999) (63)
- Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with pseudomonas exotoxin (1984) (62)
- Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer. (1986) (62)
- Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer. (1987) (62)
- Efficacy of RG7787, a Next-Generation Mesothelin-Targeted Immunotoxin, against Triple-Negative Breast and Gastric Cancers (2014) (62)
- Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts (1979) (62)
- Ultrastructural immunocytochemical localization of calmodulin in cultured cells. (1983) (62)
- Inhibition of TNF-α Produced by Kupffer Cells Protects Against the Nonspecific Liver Toxicity of Immunotoxin Anti-Tac(Fv)-PE38, LMB-2 (2000) (62)
- High Shed Antigen Levels within Tumors: An Additional Barrier to Immunoconjugate Therapy (2008) (62)
- Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis (1978) (61)
- Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA (1980) (61)
- Mesothelin Is Shed from Tumor Cells (2006) (61)
- 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts. (1999) (61)
- Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model (1999) (61)
- Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression. (1993) (60)
- A novel high‐affinity human monoclonal antibody to mesothelin (2011) (60)
- Actinomycin D: Inhibition of Phospholipid Synthesis in Chick Embryo Cells (1968) (60)
- Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line. (1983) (60)
- Cyclic guanosine monophosphate and cellular growth (1975) (59)
- Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants. (1994) (59)
- Improved stability and yield of a Fv-toxin fusion protein by computer design and protein engineering of the Fv. (1998) (59)
- Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice. (1992) (59)
- NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. (2007) (59)
- A Novel Anti-CD22 Immunotoxin, Moxetumomab Pasudotox: Phase I Study in Pediatric Acute Lymphoblastic Leukemia (ALL) (2011) (59)
- Interleukin 2 (IL2) PE40 is cytotoxic to cells displaying either the p55 or p70 subunit of the IL2 receptor. (1988) (59)
- Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts. (1978) (58)
- Clostridium barkeri sp. n (1972) (58)
- Mutants of mouse fibroblasts altered in the synthesis of cell surface glycoproteins. Preliminary evidence for a defect in the acetylation of glucosamine 6-phosphate. (1977) (58)
- Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells. (1983) (58)
- Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins. (1996) (58)
- Stimulation by cyclic AMP and ppGpp of chloramphenicol acetyl transferase synthesis. (1973) (58)
- Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA. (1980) (57)
- Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins (2003) (57)
- Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up. (2018) (57)
- Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation. (2014) (57)
- Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression. (1991) (57)
- Random recombination of antibody single chain Fv sequences after fragmentation with DNaseI in the presence of Mn2+. (1995) (57)
- Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss. (2013) (57)
- Targeting Pseudomonas exotoxin to hematologic malignancies. (1995) (57)
- Immunotoxins made with a recombinant form of Pseudomonas exotoxin A that do not require proteolysis for activity. (1993) (57)
- Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study. (2005) (57)
- PATE Gene Clusters Code for Multiple, Secreted TFP/Ly-6/uPAR Proteins That Are Expressed in Reproductive and Neuron-rich Tissues and Possess Neuromodulatory Activity* (2008) (57)
- Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts. (1981) (56)
- Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms. (1997) (56)
- Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment. (1994) (56)
- COLLOID DROPLET FORMATION IN DOG THYROID IN VITRO (1967) (56)
- Barnase toxin: A new chimeric toxin composed of pseudomonas exotoxin A and barnase (1991) (56)
- Targeting TARP, a novel breast and prostate tumor‐associated antigen, with T cell receptor‐like human recombinant antibodies (2008) (56)
- Human Breast Carcinoma Cells Express Type II IL-4 Receptors and Are Sensitive to Antitumor Activity of a Chimeric IL-4-Pseudomonas Exotoxin Fusion Protein in vitro and in vivo (2000) (56)
- Interrelationship between adenylate cyclase activity, adenosine 3':5' cyclic monophosphate phosphodiesterase activity, adenosine 3':5' cyclic monophosphate levels, and growth of cells in culture. (1973) (55)
- A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol. (1999) (55)
- Mechanism of thyroid-stimulating hormone action. Studies with dibutyl 3',5'-adenosine monophosphate and lecithinase C. (1967) (55)
- CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses. (1989) (55)
- Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma (2007) (55)
- Expression of high-affinity interleukin 4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between interleukin 4 and Pseudomonas exotoxin. (1991) (55)
- A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells. (1989) (54)
- High-density functional display of proteins on bacteriophage lambda. (2003) (54)
- A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity (2009) (54)
- Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase. (1981) (54)
- Fc Receptor-Like 3 Protein Expressed on IL-2 Nonresponsive Subset of Human Regulatory T Cells1 (2009) (54)
- Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry. (1985) (54)
- Cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities are under separate genetic control. (1974) (54)
- Reconsidering targeted toxins to eliminate HIV infection: you gotta have HAART. (1998) (54)
- Adenovirus Entry into Cells: Some New Observations on an Old Problem (1986) (54)
- High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. (2001) (54)
- Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin. (2002) (53)
- Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein. (1985) (53)
- Clathrin and coated vesicle proteins Immunological characterization. (1981) (53)
- Formation of receptosomes from plasma membrane coated pits during endocytosis: analysis by serial sections with improved membrane labeling and preservation techniques. (1983) (53)
- Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity (2019) (53)
- Comparative immunogenicity of conjugates composed of the Staphylococcus aureus type 8 capsular polysaccharide bound to carrier proteins by adipic acid dihydrazide or N-succinimidyl-3-(2-pyridyldithio)propionate (1992) (53)
- Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia. (1992) (53)
- Molecular evidence for the lack of epidermal growth factor receptor gene expression in small cell lung carcinoma cells. (1987) (52)
- Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: comparison with its single-chain analog. (1995) (52)
- Microinjection of anticlathrin antibodies into fibroblasts does not interfere with the receptor-mediated endocytosis of α2-macroglobulin (1981) (52)
- Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3 (1994) (52)
- A novel effect of EGF on mRNA stability. (1988) (52)
- Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point. (1999) (52)
- Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector. (1998) (52)
- In Vitro and in Vivo Cytotoxic Activities of Recombinant Immunotoxin 8H9(Fv)-PE38 against Breast Cancer, Osteosarcoma, and Neuroblastoma (2004) (52)
- Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis (2016) (51)
- Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. (1981) (51)
- Ultrastructural immunocytochemical localization of the transferrin receptor using a monoclonal antibody in human KB cells. (1985) (51)
- Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. (1996) (51)
- Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. (1993) (51)
- Recombinant single-chain immunotoxins against T and B cell leukemias. (1994) (51)
- Deletion and insertion mutants of the multidrug transporter. (1989) (51)
- Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (2002) (51)
- Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy (2012) (51)
- Pretreatment with Rituximab Does Not Inhibit the Human Immune Response against the Immunogenic Protein LMB-1 (2004) (51)
- Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1 (2010) (51)
- Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus. (1983) (50)
- Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter. (1990) (50)
- Selective immunosuppression of activated T cells with the chimeric toxin IL-2-PE40. Inhibition of experimental autoimmune uveoretinitis. (1989) (50)
- Retroviruses expressing different levels of the normal epidermal growth factor receptor: Biological properties and new bioassay (1989) (50)
- Adenylate cyclase activity in fibroblasts transformed by Kirsten or Moloney sarcoma viruses. Decreased activity and loss of response to prostaglandin E1. (1974) (50)
- Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. (1970) (50)
- Cytotoxic activities of recombinant immunotoxins composed of Pseudomonas toxin or diphtheria toxin toward lymphocytes from patients with adult T-cell leukemia. (1993) (50)
- Disulfide stabilization of antibody Fv: computer predictions and experimental evaluation. (1995) (50)
- Regulation of lac transcription in antibiotic-treated E. coli. (1971) (50)
- The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin. (1995) (49)
- Plasma membrane cyclic adenosine 3':5'-monophosphate phosphodiesterase of cultured cells and its modification after trypsin treatment of intact cells. (1973) (49)
- The role of the lac promotor locus in the regulation of beta-galactosidase synthesis by cyclic 3',5'-adenosine monophosphate. (1968) (49)
- Mammalian cell display for antibody engineering. (2009) (49)
- Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. (2002) (48)
- Molecular manipulations of the multidrug transporter: a new role for transgenic mice 1 (1991) (48)
- Guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities and cyclic guanosine 3':5'-monophosphate levels in normal and transformed fibroblasts in culture. (1976) (48)
- Ankrd26 Gene Disruption Enhances Adipogenesis of Mouse Embryonic Fibroblasts* (2011) (48)
- Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma. (1994) (48)
- Ultrastructural immunocytochemical localization of clathrin in cultured fibroblasts. (1981) (48)
- Role of domain II of Pseudomonas exotoxin in the secretion of proteins into the periplasm and medium by Escherichia coli. (1988) (48)
- Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin. (2000) (48)
- Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. (1998) (48)
- Potentiation of cytotoxic activity of immunotoxins on cultured human cells. (1985) (48)
- Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells. (1995) (48)
- Cyclic AMP increases the concentration of insulin receptors in cultured fibroblasts and lymphocytes. (1977) (48)
- src kinase catalyzes the phosphorylation and activation of the insulin receptor kinase. (1985) (48)
- Mutagenesis of Pseudomonas exotoxin in identification of sequences responsible for the animal toxicity. (1990) (48)
- Adenovirus-dependent increase in cell membrane permeability. (1985) (47)
- Stimulation of membranous guanylate cyclase by concentrations of calcium that are in the physiological range. (1976) (47)
- DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins. (2003) (47)
- Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin. (1993) (47)
- Initial steps in receptor-mediated endocytosis. The influence of temperature on the shape and distribution of plasma membrane clathrin-coated pits in cultured mammalian cells. (1984) (47)
- The binding of cyclic adenosine monophosphate receptor to deoxyribonucleic acid. (1972) (47)
- The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion. (1993) (47)
- Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs (2010) (47)
- Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. (1982) (47)
- Thyroid hormone down-regulates p55, a thyroid hormone-binding protein that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase. (1988) (47)
- Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts. (1995) (46)
- Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver. (1988) (46)
- A phospholipase specific for sphingomyelin from Clostridium perfringens. (1968) (46)
- Complete Remissions of Adult T-cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 and Chemotherapy to Block Immunogenicity (2015) (46)
- Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin. (1992) (46)
- Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts (2011) (45)
- Epidermal growth factor receptor. Characterization of a monoclonal antibody specific for the receptor of A431 cells. (1983) (45)
- Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity. (1997) (45)
- Effect of adenosine 3',5'-monophosphate analogues on the activity of the cyclic adenosine 3',5'-monophosphate receptor in Escherichia coli. (1972) (45)
- Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. (1981) (45)
- Myosin in cultured fibroblasts. (1974) (45)
- An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. (1996) (44)
- Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma. (1992) (44)
- Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation (2020) (44)
- Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (2004) (44)
- Fluorescent verapamil derivative for monitoring activity of the multidrug transporter. (1991) (44)
- Activation of adenylate cyclase in cultured fibroblasts by trypsin. (1978) (44)
- Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development. (1983) (44)
- Cardiac allograft survival in mice treated with IL-2-PE40. (1989) (43)
- Molecular cloning and expression of a cDNA encoding a protein detected by the ki antibody from an ovarian carcinoma (OVCAR‐3) cell line (1994) (43)
- Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin. (2002) (43)
- A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2. (1998) (43)
- Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies. (1998) (43)
- Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus (1995) (43)
- A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake. (2010) (43)
- Structure of the promoter for chicken alpha 2 type I collagen gene. (1981) (43)
- PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon (2001) (43)
- Recombinant Toxins: New Therapeutic Agents for Cancer (1995) (42)
- Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice. (2007) (42)
- Retroviral transfer of a chimeric multidrug resistance‐adenosine deaminase gene (1990) (42)
- Interleukin-4 Receptor Expression on AIDS-Associated Kaposi’s Sarcoma Cells and Their Targeting by a Chimeric Protein Comprised of Circularly Permuted Interleukin-4 and Pseudomonas Exotoxin (1997) (42)
- Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease (1988) (42)
- A primate-specific POTE-actin fusion protein plays a role in apoptosis (2009) (42)
- FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. (2007) (42)
- Strategies to Reduce the Immunogenicity of Recombinant Immunotoxins. (2018) (42)
- Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide‐stabilized anti‐TAC Fv fragment and truncated pseudomonas exotoxin (1994) (42)
- Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia. (1989) (41)
- Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments. (2002) (41)
- Filamin inhibits actin activation of heavy meromyosin ATPase (1977) (41)
- Studies on the mechanism of action of thyroid stimulating hormone on glucose oxidation. (1961) (41)
- PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach (2002) (41)
- Epidermal growth factor (EGF) receptor gene transcription (1988) (41)
- Evolution and expression of chimeric POTE–actin genes in the human genome (2006) (41)
- Translocation mediated by domain II of Pseudomonas exotoxin A: transport of barnase into the cytosol. (1992) (41)
- Expression Cloning of cDNAs That Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins (1995) (41)
- 111Indium‐labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin (1999) (40)
- In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells. (1996) (40)
- Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity. (1983) (40)
- Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis. (2015) (40)
- Cloning, molecular characterization, and expression analysis of Copine 8. (2003) (40)
- Energy-dependent calcium uptake activity in cultured mouse fibroblast microsomes. Regulation of the uptake system by cell density. (1977) (40)
- Role of cyclic adenosine 3',5'-monophosphate and the cyclic adenosine 3',5'-monophosphate receptor protein in the initiation of lac transcription. (1971) (40)
- Characterization of a re‐engineered, mesothelin‐targeted Pseudomonas exotoxin fusion protein for lung cancer therapy (2016) (40)
- Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (2006) (40)
- Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein. (2005) (40)
- Cyclic AMP and growth of fibroblasts: effect of environmental pH. (1973) (40)
- Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT) imaging (2015) (40)
- Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity (2016) (40)
- Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice. (1991) (40)
- Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3. (2000) (39)
- The purification and properties of a thyroid-stimulating factor isolated from Clostridium perfringens. (1967) (39)
- Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice. (1992) (39)
- The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion (2012) (39)
- Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. (1970) (39)
- Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats. (1989) (39)
- Administration of disulfide‐stabilized Fv‐immunotoxins B1(dsFv)‐PE38 and B3(dsFv)‐PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice (1995) (39)
- Monoclonal antibody 101 that precipitates the glycoprotein receptor for epidermal growth factor is directed against the Y antigen, not the H type 1 antigen. (1985) (39)
- Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. (2005) (39)
- Action of phospholipase C on the thyroid. Abolition of the response to thyroid-stimulating hormone. (1967) (39)
- Cell surface myosin in cultured fibroblasts (1976) (39)
- Phage display of disulfide-stabilized Fv fragments. (1995) (39)
- Pharmacokinetics and antitumor activity of a bivalent disulfide-stabilized Fv immunotoxin with improved antigen binding to erbB2. (1999) (39)
- Increased Affinity and Stability of an Anti-HIV-1 Envelope Immunotoxin by Structure-based Mutagenesis* (2002) (38)
- Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. (1986) (38)
- Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity (2018) (38)
- New Life for Immunotoxin Cancer Therapy (2015) (38)
- Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. (1980) (38)
- Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma (2017) (38)
- Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts (2014) (38)
- The direction and role of phenotypic transition between podocytes and parietal epithelial cells in focal segmental glomerulosclerosis. (2014) (38)
- Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences. (1980) (38)
- Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin. (2000) (38)
- New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene. (1991) (37)
- Molecular characterization of human clathrin. (1981) (37)
- Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor. (1982) (37)
- T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin. (2001) (37)
- Construction of an immunotoxin, HN3-mPE24, targeting glypican-3 for liver cancer therapy (2016) (37)
- Gene Transfer of Drug Resistance Genes Implications for Cancer Therapy (1994) (37)
- Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model. (1995) (37)
- Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes. (1996) (37)
- Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin. (1989) (37)
- EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells (2007) (36)
- A proper amino terminus of diphtheria toxin is important for cytotoxicity. (1991) (36)
- Cell-Specific Toxicity of a Chimeric Protein Composed of Interleukin-6 and Pseudomonas Exotoxin (IL6-PE40) on Tumor Cells (1990) (36)
- Studies of Human MDR1-MDR2 Chimeras Demonstrate the Functional Exchangeability of a Major Transmembrane Segment of the Multidrug Transporter and Phosphatidylcholine Flippase (1999) (36)
- Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent (2010) (36)
- Anoctamin and transmembrane channel-like proteins are evolutionarily related. (2009) (36)
- Regulation of galactokinase synthesis by cyclic adenosine 3',5'-monophosphate in cell-free extracts of Escherichia coli. (1971) (36)
- Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies. (1996) (36)
- Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. (1999) (36)
- A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429. (1994) (36)
- Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization. (1979) (36)
- P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells (1994) (35)
- Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA (1985) (35)
- Specific Killing of HIV-infected Lymphocytes by a Recombinant Immunotoxin Directed against the HIV-1 Envelope Glycoprotein (1998) (35)
- An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin. (1994) (35)
- In Vivo Drug‐Selectable Genes: A New Concept in Gene Therapy (1997) (35)
- Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells. (1997) (35)
- A Recombinant Immunotoxin Targeting CD22 With Low Immunogenicity, Low Nonspecific Toxicity, and High Antitumor Activity in Mice (2010) (35)
- Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence. (1978) (35)
- Mechanism of action of Pseudomonas exotoxin. Identification of a rate-limiting step. (1993) (35)
- New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma (2015) (35)
- Co-clustering and internalization of low-density lipoproteins and alpha 2-macroglobulin in human skin fibroblasts. (1982) (35)
- Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. (1971) (35)
- Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice. (1994) (35)
- Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virus. (1982) (35)
- Cancer vaccine strategies: translation from mice to human clinical trials (2018) (35)
- Multidrug resistance. (1991) (35)
- Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice. (2000) (34)
- Analysis of the Fusion of XC Cells Induced by Homogenates of Murine Leukemia Virus-Infected Cells and by Purified Murine Leukemia Virus (1971) (34)
- In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells. (1992) (34)
- Cyclic AMP, the Cyclic AMP Receptor Protein, and Their Dual Control of the Galactose Operon (1980) (34)
- Nature and function of the structural phospholipids of an arbovirus. (1969) (34)
- Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity (2018) (34)
- Identification of a transformation-specific protein induced by a rous sarcoma virus (1978) (34)
- A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. (2012) (34)
- Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis. (2015) (34)
- Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies. (1986) (34)
- Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment. (1997) (34)
- Cse1l Is Essential for Early Embryonic Growth and Development (2001) (33)
- Stabilization of a recombinant Fv fragment by base-loop interconnection and V(H)-V(L) permutation. (1997) (33)
- Pretargeted α Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid-Biotin (2004) (33)
- IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes. (1990) (33)
- An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies. (2014) (33)
- Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1 B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA) (1994) (33)
- Enhancement of the activity of immunotoxins by analogues of verapamil. (1989) (33)
- A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice (2014) (33)
- Keap1 inhibition attenuates glomerulosclerosis. (2014) (33)
- New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy (2009) (33)
- Cell membrane-specific epitopes on CD30: Potentially superior targets for immunotherapy (2005) (33)
- Monovalent immunotoxin containing truncated form of Pseudomonas exotoxin as potent antitumor agent. (1992) (33)
- Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin. (1992) (33)
- Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors (2015) (33)
- 5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia (2017) (33)
- Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild type and temperature sensitive Schmidt-Ruppin Rous sarcoma virus. (1973) (33)
- Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38. (1994) (33)
- Activation of thyroid adenyl cyclase by long-acting thyroid stimulator. (1970) (33)
- Identification of Residues That Stabilize the Single-chain Fv of Monoclonal Antibodies B3 (*) (1995) (32)
- Convection enhanced delivery of macromolecules for brain tumors. (2012) (32)
- In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene. (1988) (32)
- CYCLIC AMP MEDIATES THE CONCANAVALIN A AGGLUTINABILITY OF MOUSE FIBROBLASTS (1974) (32)
- Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo (2015) (32)
- ENERGY‐DEPENDENT CALCIUM UPTAKE BY FIBROBLAST MICROSOMES (1978) (32)
- Stimulation in vitro of glucose oxidation in thyroid by acetylcholine. (1961) (32)
- Affinity‐matured anti‐glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas (2011) (32)
- Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells. (1997) (32)
- Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. (1980) (32)
- Monensin blocks endocytosis of vesicular stomatitis virus. (1981) (32)
- NICOTINIC ACID METABOLISM. I. DISTRIBUTION OF ISOTOPE IN FERMENTATION PRODUCTS OF LABELLED NICOTINIC ACID. (1964) (32)
- ANKRD26 and Its Interacting Partners TRIO, GPS2, HMMR and DIPA Regulate Adipogenesis in 3T3-L1 Cells (2012) (32)
- Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation. (1991) (32)
- Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma. (2013) (32)
- Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein. (1991) (32)
- Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations (2019) (31)
- A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene* (2013) (31)
- Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease. (1990) (31)
- Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity (2017) (31)
- Comparison of the intracellular pathways of transferrin recycling and vesicular stomatitis virus membrane glycoprotein exocytosis by ultrastructural double-label cytochemistry. (1987) (31)
- Domain II of Pseudomonas exotoxin A arrests the transfer of translocating nascent chains into mammalian microsomes. (1994) (31)
- Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein. (2000) (31)
- Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor (2015) (31)
- Absorption and secretion of iodide by the intestine of the rat. (1957) (31)
- Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity (2017) (31)
- A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs. (1997) (31)
- Anti‐HIV‐1 immunotoxin 3B3(Fv)‐PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques (2006) (31)
- Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes (1991) (31)
- Display and selection of scFv antibodies on HEK-293T cells. (2009) (31)
- ACTH stimulation of adenyl cyclase in adrenal homogenates. (1967) (31)
- Phase I Study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia. (2017) (31)
- Regulation of intracellular calcium in chick embryo fibroblast: Calcium uptake by the microsomal fraction (1977) (31)
- Exploiting multidrug resistance to treat cancer. (1994) (31)
- A mutation affecting the catalytic subunit of cyclic AMP-dependent protein kinase in CHO cells. (1979) (31)
- PYRIDINE NUCLEOTIDES IN THE THYROID. II. THE EFFECT OF THYROID-STIMULATING HORMONE, EPINEPHRINE, SEROTONIN, ACETYLCHOLINE, MENADIONE, AND GLUCOSE CONCENTRATION ON THE LEVELS OT TPN AND TPNH. (1963) (31)
- Engineered Anti‐GPC3 Immunotoxin, HN3‐ABD‐T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention (2020) (31)
- Studies on the mechanism by which epinephrine stimulates glucose oxidation in the thyroid. (1962) (30)
- Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin (1994) (30)
- Phosphorylation of filamin and other proteins in cultured fibroblasts. (1977) (30)
- Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin. (2002) (30)
- Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo. (1998) (30)
- Simian virus 40 rapidly lowers cAMP levels in mouse cells. (1973) (30)
- Regulation of cellular growth. (1975) (30)
- The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2. (1999) (30)
- Isolation of human KB cell lines resistant to epidermal growth factor-Pseudomonas exotoxin conjugates. (1987) (30)
- Cell surface protein and neoplastic transformation (1976) (30)
- Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody. (2011) (30)
- Recognition of Mesothelin by the Therapeutic Antibody MORAb-009 (2012) (30)
- Interstitial Infusion of Glioma-Targeted Recombinant Immunotoxin 8H9scFv-PE38 (2010) (30)
- A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing. (1992) (30)
- IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein (2002) (30)
- Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys. (1992) (30)
- Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors. (2012) (30)
- Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells. (1996) (30)
- Activation of transcription by guanosine 5'-diphosphate,3'-diphosphate, transfer ribonucleic acid, and novel protein from Escherichia coli. (1975) (30)
- Studies on the activity of barnase toxins in vitro and in vivo. (1996) (30)
- A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin. (1993) (30)
- Certain functions of isolated thyroid cells. (1961) (29)
- Cyclic AMP in metabolism. (1971) (29)
- High expression of a cytokeratin-associated protein in many cancers. (2006) (29)
- Role of lecithin in the mechanism of TSH action. (1970) (29)
- Ultrastructural immunocytochemical localization of myosin in cultured fibroblastic cells. (1981) (29)
- Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial (2021) (29)
- Purification and properties of a mast cell protease. (1966) (29)
- The stability of cell surface protein to surfactants and denaturants. (1978) (29)
- The organelles of the trans domain of the cell. Ultrastructural localization of sialoglycoconjugates using Limax flavus agglutinin. (1986) (29)
- Identification and characterization of fully human anti-CD22 monoclonal antibodies (2009) (29)
- Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient–Derived Xenografts and Mesothelin as a Biomarker of Tumor Response (2016) (29)
- ATP and GTP as alternative energy sources for vinblastine transport by P‐170 in KB‐V1 plasma membrane vesicles (1992) (28)
- Pseudomonas Exotoxin and Recombinant Immunotoxins Derived from It (1993) (28)
- ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. (2001) (28)
- Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin. (1991) (28)
- Recombinant Immunotoxins: From Basic Research to Cancer Therapy (1995) (28)
- Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy. (1996) (28)
- Functional studies on the EGF receptor with an antibody that recognizes the intracellular portion of the receptor. (1986) (28)
- Effect of propranolol and phentolamine on canine and bovine responses to TSH. (1969) (28)
- Ultrastructural localization of tubulin in cultured fibroblasts. (1980) (28)
- Self-association of chicken gizzard filamin and heavy merofilamin. (1980) (28)
- The T Cell Receptor γ Chain Alternate Reading Frame Protein (TARP), a Prostate-specific Protein Localized in Mitochondria* (2004) (28)
- Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia. (2017) (28)
- Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding. (1998) (28)
- TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer (2016) (28)
- On the mechanism of action of lac repressor. (1971) (28)
- Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma (2019) (28)
- Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury. (2017) (28)
- Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (2003) (28)
- Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins. (1994) (28)
- Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines (1992) (28)
- Toxin-Based Targeted Therapy for Malignant Brain Tumors (2012) (28)
- Enhancement of the activity of immunotoxins made with either ricin A chain or Pseudomonas exotoxin in human ovarian and epidermoid carcinoma cell lines. (1988) (28)
- Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models (2019) (28)
- Inhibition of the transformation-specific kinase in ASV-transformed cells by N-α-tosyl-L-lysyl chloromethyl ketone (1979) (28)
- Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes (1986) (27)
- Sequence rearrangement and duplication of double stranded fibronectin cDNA probably occurring during cDNA synthesis by AMV reverse transcriptase and Escherichia coli DNA polymerase I (1980) (27)
- Preclinical evaluation of 111In-labeled B3 monoclonal antibody: biodistribution and imaging studies in nude mice bearing human epidermoid carcinoma xenografts. (1993) (27)
- Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice (2000) (27)
- The Regulation of lac Operon Transcription by Cyclic Adenosine 3′, 5′-Monophosphate (1970) (27)
- Expression and chromosomal localization of the gene for the human transcriptional repressor GCF. (1992) (27)
- Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin. (1993) (27)
- Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells (2007) (27)
- Minimal Residual Disease in Hairy Cell Leukemia Patients Assessed by Clone-Specific Polymerase Chain Reaction (2006) (27)
- Killing of Resistant Cancer Cells with Low Bak by a Combination of an Antimesothelin Immunotoxin and a TRAIL Receptor 2 Agonist Antibody (2011) (27)
- Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice. (1993) (27)
- Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. (2011) (27)
- Nicotinic acid metabolism. II. The isolation and characterization of intermediates in the fermentation of nicotinic acid. (1966) (27)
- A calcium requirement for movement of cultured cells (1979) (27)
- Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types (1991) (27)
- A cellular 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Purification and characterization. (1987) (27)
- CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis (2011) (27)
- Immunoconjugates in the management of hairy cell leukemia. (2015) (26)
- In vitro repression of the transcription of gas operon by purified gal repressor. (1973) (26)
- Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins (1997) (26)
- Chemoimmunotoxin therapy against a human colon tumor (HT-29) xenografted into nude mice. (1989) (26)
- Construction and characterization of bicistronic retroviral vectors encoding the multidrug transporter and beta-galactosidase or green fluorescent protein. (1998) (26)
- The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene. (1981) (26)
- Isolation of anti-mesothelin antibodies from a phage display library. (1997) (26)
- Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin. (1993) (26)
- Low pH-induced changes in Pseudomonas exotoxin and its domains: increased binding of Triton X-114 (1990) (26)
- Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice. (1997) (26)
- Binding and internalization of α2-macroglobulin by cultured fibroblasts: Effects of monovalent ionophores (1982) (26)
- Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl‐2 expression (2010) (26)
- Growth Hormone and Prolactin (1990) (26)
- Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation. (1996) (26)
- Characterization of the 3,3',5-triiodo-L-thyronine-binding site on plasma membranes from human placenta. (1985) (26)
- Guanylate cyclase in Escherichia coli. Purification and properties. (1975) (25)
- Molecular mechanism for the capture and excision of the transforming gene of avian sarcoma virus as suggested by analysis of recombinant clones (1980) (25)
- Properties and purification of a glucose-regulated protein from chick embryo fibroblasts. (1979) (25)
- Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules. (1990) (25)
- A high molecular weight phosphoprotein in cultured fibroblasts that associates with polymerized tubulin. (1978) (25)
- Rapid grouping of monoclonal antibodies based on their topographical epitopes by a label-free competitive immunoassay. (2004) (25)
- Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy. (1999) (25)
- PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers. (2002) (25)
- Expression of the MDR1 gene in human cancers. (1991) (25)
- Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. (2015) (25)
- Characterization of a cyclic AMP-resistant Chinese hamster ovary cell mutant containing both wild-type and mutant species of type I regulatory subunit of cyclic AMP-dependent protein kinase. (1985) (25)
- Antitumor activity of a thioether-linked immunotoxin: OVB3-PE. (1990) (25)
- Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8. (2013) (25)
- Isolation and characterization of genomic DNA coding for α2 Type I collagen (1980) (25)
- Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice (2011) (25)
- Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. (2006) (25)
- Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts. (1981) (24)
- Altered adenylate cyclase activity: its role in growth regulation and malignant transformation of fibroblasts. (1975) (24)
- Generation of high titer antisera in rabbits by DNA immunization. (2001) (24)
- High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate. (1999) (24)
- GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines. (1993) (24)
- Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor. (1992) (24)
- The cyclic AMP receptor of Escherichia coli: immunological studies in extracts of Escherichia coli and other organisms. (1973) (24)
- Internalization of alpha 2 macroglobulin in receptosomes. Studies with monovalent electron microscopic markers. (1981) (24)
- The directionality of locomotion of mouse fibroblasts. Role of cell adhesiveness. (1979) (24)
- Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells (1992) (24)
- Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A (2016) (24)
- Imaging of Convection Enhanced Delivery of Toxins in Humans (2011) (24)
- Cytotoxicity of IL6-PE40 and derivatives on tumor cells expressing a range of interleukin 6 receptor levels. (1990) (24)
- A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer. (1993) (23)
- Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc. (1999) (23)
- GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells. (1994) (23)
- A Lewisy epitope mimicking peptide induces anti-Lewisy immune responses in rabbits and mice (1999) (23)
- Compensation of Depleted Neuronal Subsets by New Neurons in a Local Area of the Adult Olfactory Bulb (2011) (23)
- Pre-lysosomal divergence of alpha 2-macroglobulin and transferrin: a kinetic study using a monoclonal antibody against a lysosomal membrane glycoprotein (LAMP-1). (1988) (23)
- Roles of Inhibitory Interneurons in the Cerebellar Cortex (2002) (23)
- Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity (2015) (23)
- Immunobiological treatments of hairy-cell leukaemia. (2003) (23)
- Stu8es on an ACTH-activated adenyl cyclase from a mouse adrenal tumor. (1970) (23)
- Adenovirus-dependent changes in cell membrane permeability: role of Na+, K+-ATPase (1987) (23)
- Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma (2015) (23)
- A mutant of 3T3 cells with cyclic AMP metabolism sensitive to temperature change. (1973) (23)
- Structure and regulation of a collagen gene (1982) (23)
- Mesothelin (2004) (23)
- DNase I sensitivity of the alpha 2(I) collagen gene: correlation with its expression but not with its methylation pattern. (1984) (23)
- Chimeric cytotoxin IL2-PE40 inhibits relapsing experimental allergic encephalomyelitis (1991) (23)
- TGFα-PE40 inhibits non-small cell lung cancer growth (1994) (23)
- Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A. (2015) (23)
- Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers. (2000) (23)
- Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene. (1997) (22)
- Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites. (1995) (22)
- Combining the Antimesothelin Immunotoxin SS1P With the BH3-mimetic ABT-737 Induces Cell Death in SS1P-resistant Pancreatic Cancer Cells (2014) (22)
- Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (1999) (22)
- Characterization of B1(Fv)PE38 and B1(dsFv)PE38: single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice. (1995) (22)
- IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells. (1990) (22)
- Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo. (1999) (22)
- Human renal cell carcinoma cells are sensitive to the cytotoxic effect of a chimeric protein composed of human interleukin-4 and Pseudomonas exotoxin. (1994) (22)
- Multidrug resistant transgenic mice as a novel pharmacologic tool (1991) (22)
- Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides. (2001) (22)
- Synergistic Antitumor Activity of Anti-CD25 Recombinant Immunotoxin LMB-2 with Chemotherapy (2011) (22)
- The insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin. (2013) (22)
- Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial (2017) (22)
- The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders (1996) (22)
- Diminished content of plasma membrane-associated myosin in transformed fibroblasts (1976) (22)
- Immunotoxins in the treatment of refractory hairy cell leukemia. (2006) (22)
- Immunotoxins with decreased immunogenicity and improved activity (2011) (22)
- Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results (2015) (22)
- Rapid and specific uptake of anti-Tac disulfide-stabilized Fv by interleukin-2 receptor-bearing tumors. (1995) (22)
- The relationship between cell surface protein and glucose and α‐aminoisobutyrate transport in transformed chick and mouse cells (1976) (21)
- Chromosomal localization of the gene for a human thyroid hormone-binding protein. (1988) (21)
- The performance of e23(Fv)PEs, recombinant toxins targeting the erbB-2 protein. (1996) (21)
- Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions. (1990) (21)
- Isolation of new anti‐CD30 scFvs from DNA‐immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin (2001) (21)
- Isolation of the gal repressor. (1971) (21)
- Selection and maintenance of multidrug-resistant cells. (1998) (21)
- Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand. (1992) (21)
- Loss of mesothelin expression by mesothelioma cells grown in vitro determines sensitivity to anti-mesothelin immunotoxin SS1P. (2012) (21)
- In vitrom stimulation of the hexose monophosphate pathway in thyroid by thyroid stimulating hormone (1959) (21)
- Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2). (1999) (21)
- Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II (1993) (21)
- Biochemistry of the Nitrogen-Containing Hormones (1966) (21)
- Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer. (2001) (21)
- Detection of Multidrug Resistance (MDR1) Gene RNA Expression in Human Tumors by a Sensitive Ribonuclease Protection Assay (1989) (21)
- Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia (2011) (21)
- The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli. (1974) (21)
- Interleukin‐4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin (1994) (21)
- Recombinant single‐chain and disulfide‐stabilized Fv‐immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice (1996) (21)
- Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins (2004) (21)
- Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes (2000) (20)
- Isolation and Characterization of the Human MDR (P-Glycoprotein) Genes (1991) (20)
- IL-2-PE40 is cytotoxic for activated T lymphocytes expressing IL-2 receptors. (1988) (20)
- Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection. (2011) (20)
- Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. (1970) (20)
- Multidrug Resistance Transporter (1996) (20)
- Identification of cytotoxic T‐lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4) (2007) (20)
- Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury (2014) (20)
- Abrogation of Head and Neck Squamous Cell Carcinoma Growth by Epidermal Growth Factor Receptor Ligand Fused to Pseudomonas Exotoxin Transforming Growth Factor α-PE38 (2004) (20)
- EGF induces receptor down‐regulation with no receptor recycling in KB cells (1985) (20)
- Technetium-99m labeling and biodistribution of anti-TAC disulfide-stabilized Fv fragment. (1997) (20)
- Clinical trials with Pseudomonas exotoxin immunotoxins. (1998) (20)
- Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria (2016) (20)
- The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS. (1998) (20)
- Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer (2020) (20)
- Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. (1994) (20)
- Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. (2008) (19)
- TGFα-anti-Tac(Fv)-PE40: A bifunctional toxin cytotoxic for cells with EGF or IL2 receptors (1990) (19)
- Reversible and irreversible inhibitors of clustering of alpha 2M in clathrin-coated pits on the surface of fibroblasts. (1982) (19)
- Cell transformation. (1979) (19)
- Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti–PD-1 antibody in patients with mesothelioma and mouse tumor models (2020) (19)
- Immunotoxins and recombinant toxins in the treatment of solid carcinomas. (1993) (19)
- Advances in the Development of Anti-CD22 Immunotoxins Containing Pseudomonas Exotoxin for Treatment of Hematologic Malignancies (2011) (19)
- Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of murine sarcoma virus. (1983) (19)
- Cytotoxic activity of chimeric toxins containing the epidermal growth factor-like domain of heregulins fused to PE38KDEL, a truncated recombinant form of Pseudomonas exotoxin. (1995) (19)
- Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury. (2014) (19)
- Evaluation of a new DTPA-derivative chelator: comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts. (1993) (19)
- Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers (2012) (19)
- Further studies on effects of thyroid-stimulating hormone on thyroid glucose oxidation. (1963) (19)
- Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure. (1995) (19)
- Unusual methylation pattern of the alpha 2 (l) collagen gene. (1982) (18)
- In vivo models of P-glycoprotein-mediated multidrug resistance. (1994) (18)
- Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab. (2012) (18)
- Targeting growth factor receptors with fusion toxins. (1992) (18)
- Acquisition of multiple copies of a mutant topoisomerase IIα allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines (1995) (18)
- Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations. (1999) (18)
- SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors (2018) (18)
- Phase 1 study of the immunotoxin LMB‐100 in patients with mesothelioma and other solid tumors expressing mesothelin (2020) (18)
- Aminosyn II effectively blocks renal uptake of 18F-labeled anti-tac disulfide-stabilized Fv. (1998) (18)
- Localization of rat thyroid alkaline protease to mast cells. (1966) (18)
- Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins (2016) (18)
- Cyclic AMP-dependent phosphorylation in intact cells and in cell-free extracts from Chinese hamster ovary cells. Studies with wild type and cyclic AMP-resistant mutants. (1981) (18)
- In vitro antibody affinity maturation targeting germline hotspots. (2009) (18)
- Treatment of acute myelocytic leukemia with interleukin-6 Pseudomonas exotoxin fusion protein in a rat leukemia model. (1996) (18)
- Endocytosis and membrane traffic in cultured cells. (1984) (18)
- Selective effects of MgCl2 and temperature on the initiation of transcription at lac, gal, and lambda promoters. (1975) (18)
- A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system (2013) (18)
- Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin (1991) (18)
- PRAC2: A new gene expressed in human prostate and prostate cancer (2003) (18)
- The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein. (2005) (18)
- Crystal structure of the disulfide‐stabilized Fv fragment of anticancer antibody B1: Conformational influence of an engineered disulfide bond (1998) (18)
- Effect of fluoride on the metabolic activity of thyroid slices. (1968) (18)
- Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice. (1992) (18)
- Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38. (2017) (18)
- Heparin-binding transforming growth factor alpha-Pseudomonas exotoxin A. A heparan sulfate-modulated recombinant toxin cytotoxic to cancer cells and proliferating smooth muscle cells. (1993) (18)
- Development of Recombinant Immunotoxins for Hairy Cell Leukemia (2020) (18)
- Pseudomonas exotoxin--immunotoxins. (1988) (18)
- Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors (2013) (18)
- Expression of mesothelin in thymic carcinoma and its potential therapeutic significance. (2016) (17)
- Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2. (1999) (17)
- Anti‐Tac(Fab)‐PE40, a recombinant double‐chain immunotoxin which kills interleukin‐2‐receptor‐bearing cells and induces complete remission in an in vivo tumor model (1994) (17)
- Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737 (2011) (17)
- alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites. (1983) (17)
- Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy (2006) (17)
- Expression of the MDR1 Gene in Normal Human Tissues (1991) (17)
- A chimeric protein comprised of IL-4 and Pseudomonas exotoxin is cytotoxic for activated human lymphocytes. (1994) (17)
- BL22 and lymphoid malignancies. (2006) (17)
- CYCLIC AMP‐TREATED SARCOMA CELLS ACQUIRE SEVERAL MORPHOLOGICAL CHARACTERISTICS OF NORMAL FIBROBLASTS (1971) (17)
- Factors influencing the in vivo pharmacokinetics of peptides and antibody fragments: the pharmacokinetics of two PET-labeled low molecular weight proteins. (1997) (17)
- Cytotoxicity of recombinant Fab and Fv immunotoxins on adult T-cell leukemia lymph node and blood cells in the presence of soluble interleukin-2 receptor. (1994) (17)
- The improvement of an anti-CD22 immunotoxin (2011) (17)
- Biochemical Basis for Multidrug Resistance in Cancer (1991) (17)
- Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability. (1998) (17)
- Studies on the mechanism of action of the gal repressor. (1973) (16)
- Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1. (2016) (16)
- Cyclic AMP-dependent phosphorylation of the actin-binding protein filamin. (1978) (16)
- Magnetic-affinity cell sorting of human multidrug-resistant cells. (1991) (16)
- B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3. (1994) (16)
- Alanine scanning mutagenesis identifies surface amino acids on domain II of Pseudomonas exotoxin required for cytotoxicity, proper folding, and secretion into periplasm. (1992) (16)
- Redirecting Pseudomonas exotoxin. (1991) (16)
- Combination Treatments with the PKC Inhibitor, Enzastaurin, Enhance the Cytotoxicity of the Anti-Mesothelin Immunotoxin, SS1P (2013) (16)
- Inhibition by bacitracin of high affinity binding of 125I‐α2M to plasma membranes (1981) (16)
- Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner. (2019) (16)
- PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells. (1993) (16)
- Immunotoxins and recombinant toxins for cancer treatment. (1994) (16)
- Expression of POTE protein in human testis detected by novel monoclonal antibodies. (2008) (16)
- Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy (2020) (16)
- The heparin-binding domain of heparin-binding EGF-like growth factor can target Pseudomonas exotoxin to kill cells exclusively through heparan sulfate proteoglycans. (1994) (16)
- The purification and quantitation of myosin from cultured cells. (1976) (16)
- In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins. (1994) (15)
- PYRIDINE NUCLEOTIDES IN THE THYROID. I. A METHOD FOR THE MEASUREMENT OF OXIDIZED AND REDUCED TRIPHOSPHOPYRIDINE NUCLEOTIDES WITH THE USE OF 6-PHOSPHOGLUCONATE-1-C14. (1963) (15)
- Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase. (2002) (15)
- Effects of dimethylsulfoxide on the E. coli gal operon and on bacteriophage lambda in vivo. (1974) (15)
- A mutant fibroblast cell line defective in glycoprotein synthesis due to a deficiency of glucosamine phosphate acetyltransferase. (1978) (15)
- Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents. (2002) (15)
- Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src. (1985) (15)
- Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress (2018) (15)
- RECEPTOR‐MEDIATED ENDOCYTOSIS OF α2‐MACROGLOBULIN: INHIBITION BY IONOPHORES AND STIMULATION BY Na+ AND HCO3‐ (1982) (15)
- Treatment of corneal allograft rejection with the cytotoxin IL-2-PE40. (1991) (15)
- Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome (2014) (15)
- Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers (1997) (15)
- Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein. (1999) (15)
- Selective elimination in vitro of alloresponsive T cells to human transplantation antigens by toxin or radionuclide conjugated anti-IL-2 receptor (Tac) monoclonal antibody. (1990) (15)
- Circularly permuted interleukin 4 retains proliferative and binding activity. (1995) (15)
- Efficiency of Immunotoxin Cytotoxicity Is Modulated by the Intracellular Itinerary (2012) (15)
- Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation. (1996) (15)
- CD21−/low Marginal Zone B Cells Highly Express Fc Receptor–like 5 Protein and Are Killed by Anti–Fc Receptor–like 5 Immunotoxins in Hepatitis C Virus–Associated Mixed Cryoglobulinemia Vasculitis (2014) (15)
- In vitro stimulation of glucose oxidation in thyroid by serotonin. (1962) (15)
- Purification and Partial Characterization of an Interleukin 2-Pseudomonas Exotoxin Fusion Protein (1988) (15)
- Biochemical characterization of human GCF transcription factor in tumor cells. (1995) (15)
- Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway (2017) (14)
- Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction. (2012) (14)
- Amatuximab, a chimeric monoclonal antibody to mesothelin, in combination with pemetrexed and cisplatin in patients with unresectable pleural mesothelioma: Results of a multicenter phase II clinical trial. (2012) (14)
- KB Carcinoma Cell Lines Reduced Drug Accumulation in Multiply Drug-resistant Human (2006) (14)
- EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery (2016) (14)
- Molecular biology of drug resistance (1987) (14)
- Effect of sphingomyelinase from Clostridium perfringens on the metabolic activity and phospholipid composition of thyroid slices. (1968) (14)
- Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin. (1993) (14)
- Use of Pseudomonas aeruginosa toxin A in the construction of conjugate vaccines and immunotoxins. (1987) (14)
- Transfer of the MDR1 (multidrug resistance) gene: protection of hematopoietic cells from cytotoxic chemotherapy, and selection of transduced cells in vivo. (1995) (14)
- Modulation of fibronectin gene activity in chick embryo fibroblasts transformed by a temperature-sensitive strain (ts68) of Rous sarcoma virus. (1985) (14)
- Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion. (1991) (14)
- Binding of Drugs and ATP by P-Glycoprotein and Transport of Drugs by Vesicles from Human Multidrug-Resistant Cells (1991) (14)
- Identification and Enhancement of HLA-A2.1-Restricted CTL Epitopes in a New Human Cancer Antigen-POTE (2013) (14)
- Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells. (1992) (14)
- Methylation-Associated Partial Down-Regulation of Mesothelin Causes Resistance to Anti-Mesothelin Immunotoxins in a Pancreatic Cancer Cell Line (2015) (14)
- Regulation of gene transcription in Escherichia coli by cyclic AMP. (1972) (14)
- Morphologic Methods in the Study of Endocytosis in Cultured Cells (1985) (14)
- THE COLLAGEN GENE (1981) (13)
- Mesothelin Expression in Advanced Gastroesophageal Cancer Represents a Novel Target for Immunotherapy (2016) (13)
- Fluorescent rhodamine‐labeled thyroid hormone derivatives (1979) (13)
- Image intensification techniques for detection of proteins in cultured cells. (1983) (13)
- The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts (1972) (13)
- A reversible multi-well chamber for incubation of cultured cells with small volumes: application to screening of hybridoma fusions using immunofluorescence microscopy. (1990) (13)
- The use of immunotoxins for cancer therapy. (1993) (13)
- Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system. (1998) (13)
- TARP: A nuclear protein expressed in prostate and breast cancer cellsderived from an alternate reading frame of the T cell receptor gamma chainlocus [In Process Citation] (2000) (13)
- Modulating Mesothelin Shedding to Improve Therapy (2012) (13)
- Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models (2019) (13)
- The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin. (1989) (13)
- Effect of epidermal growth factor on prostaglandin E1‐stimulated accumulation of cyclic AMP in fibroblastic cells (1979) (13)
- POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. (2012) (13)
- Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40. (1991) (13)
- Approach to the patient after relapse of hairy cell leukemia (2009) (13)
- Recombinant toxins. (1994) (13)
- Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity. (1994) (13)
- Analysis of sequences required for the cytotoxic action of a chimeric toxin composed of Pseudomonas exotoxin and transforming growth factor alpha. (1994) (13)
- Regulation of transglutaminase activity in Chinese hamster ovary cells. (1980) (13)
- Phase I Dose-Escalation Study of CAT-8015 (HA22), A CD22-Specific Targeted Immunotoxin, in Relapsed or Refractory Hairy Cell Leukemia. (2009) (12)
- Synthesis of epidermal growth factor (EGF) receptor in vitro using SP6 RNA polymerase-transcribed template mRNA. (1986) (12)
- Anti-CD 22 Immunotoxin RFB 4 ( dsFv )-PE 38 ( BL 22 ) for CD 22-Positive Hematologic Malignancies of Childhood : Preclinical Studies and Phase I Clinical Trial (2010) (12)
- Effects of anterior pituitary hormones on glucose metabolism by rat mammary gland in vitro. (1961) (12)
- Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase (1981) (12)
- Bortezomib Reduces Pre-Existing Antibodies to Recombinant Immunotoxins in Mice (2015) (12)
- Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates (1990) (12)
- Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene. (1981) (12)
- Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system (1998) (12)
- TP-3 Immunotoxins Improve Antitumor Activity in Mice with Osteosarcoma (2005) (12)
- Improving the In Vivo Efficacy of an Anti-Tac (CD25) Immunotoxin by Pseudomonas Exotoxin A Domain II Engineering (2018) (12)
- Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia. (2019) (12)
- Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis. (1995) (12)
- In situ Localization of the Human Multidrug‐resistance Gene mRNA Using Thymine‐Thymine Dimerized Single‐stranded cDNA (1990) (12)
- Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment. (1998) (12)
- Effect of Antigen Shedding on Targeted Delivery of Immunotoxins in Solid Tumors from a Mathematical Model (2014) (12)
- Partial purification and characterization of the messenger RNA for cell fibronectin. (1979) (12)
- Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity. (1970) (12)
- Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules. (2003) (12)
- Molecular biology of multidrug resistance in human cells. (1988) (12)
- Expression of Lewis carbohydrate antigens in metastatic lesions from human prostatic carcinoma (1998) (12)
- Antitumor activity of SS1P with pemetrexed and cisplatin for front-line treatment of pleural mesothelioma and utility of serum mesothelin as a marker of tumor response. (2011) (12)
- Alpha 2-macroglobulin binding to cultured fibroblasts: identification by affinity chromatography of high-affinity binding sites. (1983) (12)
- Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. (1996) (12)
- Insertion of constant region domains of human IgG1 into CD4-PE40 increases its plasma half-life. (1993) (12)
- 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two (2016) (11)
- Results from an international phase 2 study of the anti‐CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B‐lineage acute lymphoblastic leukemia (2020) (11)
- P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells. (1998) (11)
- Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin. (1993) (11)
- Retroviral transfer of human MDR1 gene into human T lymphocytes. (1998) (11)
- Abstract CT230: Pediatric phase 1 trial of moxetumomab pasudotox: Activity in chemotherapy refractory acute lymphoblastic leukemia (ALL) (2014) (11)
- Nucleotide sequence of a collagen cDNA‐fragment coding for the carboxyl end of proα1(I)‐chains (1980) (11)
- Thyroglobulin: Evidence for Crystallization and Association (1966) (11)
- Vinculin phosphorylation by the src kinase: inhibition by chlorpromazine, imipramine and local anesthetics. (1982) (11)
- Tumor and organ uptake of (64)Cu-labeled MORAb-009 (amatuximab), an anti-mesothelin antibody, by PET imaging and biodistribution studies. (2015) (11)
- A repetitive structure in the chick alpha 2-collagen gene. (1981) (11)
- Construction and characterization of a selectable multidrug resistance-glucocerebrosidase fusion gene. (1996) (11)
- A Lewis(y) epitope mimicking peptide induces anti-Lewis(y) immune responses in rabbits and mice. (1999) (11)
- An epidermal growth factor‐ricin a chain (EGF‐RTA)‐resistant mutant and an epidermal growth factor‐Pseudomonas endotoxin (EGF‐PE)‐resistant mutant have distinct phenotypes (1989) (11)
- Inhibitors of endocytosis perturb phospholipid metabolism in rabbit neutrophils and other cells. (1983) (11)
- Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats (2016) (11)
- Global polysome analysis of normal and injured podocytes. (2019) (11)
- Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors (2019) (11)
- Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization. (1994) (10)
- Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits (2019) (10)
- Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit alpha 2-macroglobulin binding and uptake. (1986) (10)
- Genetic analysis of the murtidrug transporter (1995) (10)
- Mechanism of cyclic AMP effect on nutrient transport in Chinese hamster ovary cells. A genetic approach. (1980) (10)
- Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates (1988) (10)
- Microinjection of anticlathrin antibodies into cultured fibroblasts: clathrin-coated structures in receptor-mediated endocytosis and in exocytosis. (1982) (10)
- Clinical applications of immunotoxins. Introduction. (1998) (10)
- A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting. (1996) (10)
- Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity (2019) (10)
- Affinity-matured recombinant immunotoxin targeting gangliosides 3′-isoLM1 and 3′,6'-isoLD1 on malignant gliomas (2013) (10)
- Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies (2017) (10)
- Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A (2001) (9)
- Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis (2021) (9)
- Mutant KB cells with decreased EGF receptor expression: Biochemical characterization (1987) (9)
- The purification and analysis of mechanism of action of a cyclic AMP-receptor protein from Escherichia coli. (1974) (9)
- Characterization of an MDR1 retroviral bicistronic vector for correction of X-linked severe combined immunodeficiency (1998) (9)
- TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. (2003) (9)
- Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts. (1982) (9)
- Complete Remissions In 3 of 12 Patients with Pediatric Acute Lymphoblastic Leukemia (ALL) During Phase I Testing of the Anti-CD22 Immunotoxin Moxetumomab Pasudotox (2010) (9)
- Recombinant F(ab') C242-Pseudomonas exotoxin, but not the whole antibody-based immunotoxin, causes regression of a human colorectal tumor xenograft. (1995) (9)
- Cytotoxic Effects of TGF‐α‐Pseudomonas Exotoxin A Fusion Protein in Human Pancreatic Carcinoma Cells (1996) (9)
- Chapter 1 The Multidrug Transporter: Mechanistic Considerations (1994) (9)
- 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox (2018) (9)
- The role of intracellular pH in ligand internalization (1986) (9)
- An episomally maintained MDR1 gene for gene therapy. (2001) (9)
- Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009. (2012) (9)
- Studies on the regulation of insulin receptors in cultured BALB/3T3 fibroblasts. (1978) (9)
- Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG. (1997) (9)
- Phase I trial of recombinant immunotoxin CAT-8015 (HA22) in multiply relapsed hairy cell leukemia. (2010) (9)
- Phase I Clinical Trial of the Anti-CD22 Immunotoxin CAT-8015 (HA22) for Pediatric Acute Lymphoblastic Leukemia (ALL). (2009) (9)
- Reduction of EGF receptor synthesis by antisense RNA vectors (1986) (9)
- Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine (2020) (8)
- Megakaryocytic Potentiating Factor and Mature Mesothelin Stimulate the Growth of a Lung Cancer Cell Line in the Peritoneal Cavity of Mice (2014) (8)
- A polymorphic HindIII site within the human multidrug resistance gene 1 (MDR1). (1988) (8)
- [50] The purification and analysis of mechanism of action of a cyclic AMP-receptor protein from Escherichia coli (1974) (8)
- Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients (2017) (8)
- Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia (2018) (8)
- The cellular entry of EGF and transferrin: a problem in intracellular sorting. (1985) (8)
- Stimulation of lac transcription by guanosine 5'-diphosphate 2'(or 3')-diphosphate and transfer ribonucleic acid. (1973) (8)
- Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells. (2003) (8)
- Moxetumomab Pasudotox-Tdfk in Heavily Pretreated Patients with Relapsed/Refractory Hairy Cell Leukemia (HCL): Long-Term Follow-up from the Pivotal Phase 3 Trial (2019) (8)
- Preclinical development of anti-BCMA immunotoxins targeting multiple myeloma. (2018) (8)
- Lipoprotein Modulation of Proteinuric Renal Injury (2019) (8)
- Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin (2018) (8)
- A Phase 1 Study of Moxetumomab Pasudotox, An Anti-CD22 Recombinant Immunotoxin, In Relapsed/Refractory Hairy Cell Leukemia (HCL): Updated Results (2010) (8)
- Small chimeric toxins containing only transforming growth factor alpha and domain III of Pseudomonas exotoxin with good antitumor activity in mice. (1994) (8)
- Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A–Based Immunotoxins (2016) (8)
- Studies with cyclic adenosine monophosphate receptor and stimulation of in vitro transcription of the Gal operon. (1974) (8)
- Multiple proteases are involved in mesothelin shedding by cancer cells (2020) (8)
- Factors that Determine Sensitivity and Resistances of Tumor Cells Towards Antibody-Targeted Protein Toxins (2015) (8)
- Pre-Clinical Evaluation of the Anti-CD22 Immunotoxin CAT-8015 in Combination with Chemotherapy Agents for Childhood B-Precursor Acute Lymphoblastic Leukemia (Pre-B ALL). (2007) (7)
- Large Molecule Therapeutics In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG 7787 in Pancreatic Cancer (2014) (7)
- Cloning and expression of the H chain V region of antibody OVB3 that reacts with human ovarian cancer. (1988) (7)
- Pharmacokinetic Analysis Of Response In Hairy Cell Leukemia Treated By Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (2013) (7)
- Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins (2016) (7)
- Abstract 4510: RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors (2014) (7)
- Cyclic AMP and the malignant transformation of cells. (1975) (7)
- Megakaryocyte Potentiating Factor as a Predictive Biomarker for Therapies Against Malignant Mesothelioma. (2018) (7)
- Efficient ablation by immunotoxin‐mediated cell targeting of the cell types that express human interleukin‐2 receptor depending on the internal ribosome entry site (2001) (7)
- Recombinant immunotoxins (2005) (7)
- Palmitoylation of POTE family proteins for plasma membrane targeting. (2007) (7)
- 280 Updated results of the phase I study of SS1(dsFv)PE38 for targeted therapy of mesothelin expressing cancers (2004) (7)
- Serial section analysis of clathrin-coated pits in rat liver sinusoidal endothelial cells. (1985) (7)
- Purification and properties of avian and mammalian filamins. (1982) (7)
- Affinity purification and characterization of anti-Tac(Fv)-C3-PE38KDEL: A highly potent cytotoxic agent specific to cells bearing IL-2 receptors. (1993) (7)
- Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor. (1984) (7)
- Anti-drug antibodies to LMB-100 are enhanced by mAbs targeting OX40 and CTLA4 but not by mAbs targeting PD1 or PDL-1. (2018) (7)
- Epidermal growth factor‐dependent growth of human KB cells in a defined medium and altered growth factor requirements of KB mutants resistant to EGF‐Pseudomonas exotoxin conjugates (1988) (7)
- Stabilization of Hypoxia-Inducible Factor Ameliorates Glomerular Injury Sensitization after Tubulointerstitial Injury. (2020) (7)
- A divalent recombinant immunotoxin formed by a disulfide bond between the extension peptide chains. (2001) (7)
- Changes in diphosphopyridine nucleotide and triphosphopyridine nucleotide levels produced by thyroid-stimulating hormone in thyroid slices in vitro. (1961) (7)
- Involvement of Na+ and HCO 3− in receptor‐mediated endocytosis of α2‐macroglobulin, epidermal growth factor, and vesicular stomatitis virus (1982) (7)
- CURRENT DIRECTIONS IN RESEARCH ON CYCLIC AMP (1972) (7)
- 12 making fusion toxins to target leukemia and lymphoma. (2000) (7)
- Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer. (2019) (7)
- HYDROLYSIS OF THYROGLOBULIN CATALYZED BY RAT THYROID PARTICLES. (1965) (7)
- RECEPTOR‐MEDIATED ENDOCYTOSIS OF α2‐MACROGLOBULIN: SOLUBILIZATION AND PARTIAL PURIFICATION OF THE FIBROBLAST α2‐MACROGLOBULIN RECEPTOR (1983) (6)
- Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors (2022) (6)
- Receptor-Mediated Endocytosis: General Considerations and Morphological Approaches (1983) (6)
- Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells (1984) (6)
- Recombinant anti-erbB 2 immunotoxins containing Pseudomonas exotoxin ( chemotherapy / monoclonal antibodies / growth factor receptors ) (6)
- Specific inhibition of virus growth in cells treated with phospholipase C. (1968) (6)
- Antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine binding protein of rat pituitary GH3 cells: partial characterization and cross-species immunoreactivity. (1984) (6)
- Indirect podocyte injury manifested in a partial podocytectomy mouse model. (2021) (6)
- Hydrolysis of thyroglobulin by a mast cell enzyme present in rat thyroid homogenates. (1966) (6)
- RECEPTOR-MEDIATED ENDOCYTOSIS OF HORMONES IN CULTURED FIBROBLASTS (1981) (6)
- Wide Variability in the Time Required for Immunotoxins to Kill B Lineage Acute Lymphoblastic Leukemia Cells: Implications for Trial Design (2016) (6)
- Effect of cell density on energy‐dependent calcium uptake by Balb/c 3T3 membranes is independent of protein synthesis and attachment to substratum (1979) (6)
- The role of cyclic AMP in malignant transformation. (1975) (6)
- Receptosomes, endosomes, CURL: different terms for the same organelle system (1985) (6)
- Solubilization and characterization of a membrane 3, 3', 5-triiodo-L-thyronine binding protein from rat pituitary tumor GH3 cells. (1985) (6)
- Do coated vesicles exist (1984) (6)
- Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin for targeted therapy of mesothelin expressing mesotheliomas, ovarian and pancreatic cancer (2007) (6)
- Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera (2006) (6)
- Sensitivity of human acute myeloid leukaemia to diphtheria toxin‐GM‐CSF fusion protein (1997) (6)
- Putative “MDR enhancer” is located on human chromosome 20 and not linked to the MDRI gene on chromosome 7 (1994) (6)
- Structure of the promoter for chicken a 2 i type I collagen gene (6)
- Regression of Adult T-Cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 Preceded by Chemotherapy (2011) (6)
- Moxetumomab pasudotox in heavily pretreated patients with relapsed/refractory hairy cell leukemia: Results of a pivotal international study. (2018) (5)
- Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia (2020) (5)
- Cyclic adenosine 5'-monophosphate in Escherichia coli (1976) (5)
- Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein. (1998) (5)
- Antitumor Activity of a Transforming Growth Factor a-Pseudomonas Exotoxin Fusion Protein (TGF-a-PE40) (2006) (5)
- Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells. (1998) (5)
- Control of expression of genetic information in E. coli by cyclic AMP. (1972) (5)
- In vitro and in vivo activity of a recombinant toxin, OLX-209, which targets the erbB-2 oncoprotein. (1994) (5)
- pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein. (1998) (5)
- BL22, a Recombinant Anti-CD22 Immunotoxin, Induces Cell Cycle Arrest and Apoptosis in B-Cell Lymphoma. (2004) (5)
- Pseudomonas exotoxin: recombinant conjugates as therapeutic agents. (1992) (5)
- TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells (2014) (5)
- Anti‐prostate immunotoxins: Cytotoxicity of E4 antibody–pseudomonas exotoxin constructs (1998) (5)
- Receptor-mediated Endocytosis in Cultured Cells: Coated Pits, Receptosomes, and Lysosomes (1981) (5)
- Immunotoxins: From Design to Clinical Application (2021) (5)
- Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells. (2008) (5)
- Rous sarcoma virus transformed cells are resistant to cyclic AMP (1982) (5)
- Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src (1984) (5)
- Characterization of a monoclonal antibody, OVB1, which binds to a unique determinant in human ovarian carcinomas and myeloid cells. (1989) (4)
- Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy (2018) (4)
- Characterization of CAT-8015: A Pseudomonas exotoxin based immunotoxin for the treatment of CD22-related hematological malignancies (2006) (4)
- 125. Transit of Epidermal Growth Factor Through the Coated Pits of the Golgi. (1982) (4)
- TGF alpha-PE40 inhibits non-small cell lung cancer growth. (1994) (4)
- Construction of MDR1 vectors for gene therapy. (1998) (4)
- Minimal residual disease in hairy cell leukemia patients treated by BL22 (2006) (4)
- Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury. (2015) (4)
- Exploiting bias in a non-immune human antibody library to predict antigenicity. (2011) (4)
- Elevated Serum Megakaryocyte Potentiating Factor as a Predictor of Poor Survival in Patients with Mesothelioma and Primary Lung Cancer. (2018) (4)
- Role of HLA-DP in the Presentation of Epitopes from the Truncated Bacterial PE38 Immunotoxin (2016) (4)
- Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity. (1982) (4)
- Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice. (2002) (4)
- Role of synaptic integration of dopaminergic and cholinergic transmissions in basal ganglia function (2003) (4)
- Erratum to: Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1 (2010) (4)
- Megalin Participates in the Early Injury of Proximal Tubule Cells in Glomerular Disease with Non-selective Proteinuria (2009) (4)
- A Novel Anti-CD22 Immunotoxin, Moxetumomab Pasudotox (HA22, CAT-8015): Activity in Pediatric Patients with Relapsed Acute Lymphoblastic Leukemia (ALL) After Allogeneic Hematopoietic Stem Cell Transplantation (SCT) (2012) (4)
- Targeted therapy of mesothelin expressing mesotheliomas (MM), ovarian cancer (OC) and pancreatic cancer (PC): Results of phase I study of SS1(dsFv)PE38 (SS1P) (2004) (4)
- Prostaglandin E1 binding and adenylate cyclase activation in normal and transformed fibroblasts. (1980) (4)
- Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system. (1982) (4)
- Non-AUG translational initiation of a short CAPC transcript generating protein isoform. (2009) (4)
- High Response Rate of Moxetumomab Pasudotox in Relapsed/Refractory Hairy Cell Leukemia Includes Eradication of Minimal Residual Disease: Potential Importance for Outcome (2015) (4)
- In vitro and in vivo suppression of interleukin-2-activated killer cell activity by chimeric proteins between interleukin-2 and Pseudomonas exotoxin. (1992) (4)
- Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis (1978) (4)
- Expression of a full-length cDNA f (2016) (3)
- non-Hodgkin lymphoma as a target of immunotoxins FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell (2008) (3)
- Expression of a human multidrug-resistance cDNA (MDR1) under the control of a beta-actin promoter in transgenic mice. (1991) (3)
- Monoclonal antibodies of the mouse (1991) (3)
- Phase I clinical trial of antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of advanced pleural mesothelioma. (2010) (3)
- Decreased accumulation of [14c]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptakeThis article is a US Government work and, as such, is in the public domain in the United States of America. (2000) (3)
- Mesothelin expression in patients as a novel target in gastric cancer. (2014) (3)
- Targeted therapy of mesothelin expressing mesotheliomas (MM), ovarian cancer (OC) and pancreatic cancer (PC): Results of phase I study of SS1(dsFv)PE38 (SS1P). (2004) (3)
- A phase I study of mesothelin-targeted immunotoxin LMB-100 in combination with nab-paclitaxel for patients with previously treated advanced pancreatic cancer. (2019) (3)
- Moxetumomab pasudotox as re-treatment for heavily-pretreated relapsed hairy cell leukemia (2021) (3)
- Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells. (1992) (3)
- Efficacy and safety of moxetumomab pasudotox (moxe) in adult patients (pts) with relapsed/refractory hairy cell leukemia (HCL) in relation to drug exposure, baseline disease burden, and immunogenicity. (2018) (3)
- Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. (1984) (3)
- Cytotoxicity of TGFα-PE40 and correlation to expression of epidermal growth factor receptor (1995) (3)
- 50 Antibody-based treatment for mesothelioma: Clinical trials and laboratory studies (2006) (3)
- A phase I study of MORab-009, a monoclonal antibody against mesothelin, in mesothelioma, pancreatic and ovarian cancer (2008) (3)
- Selectable Markers for Gene Therapy (2008) (3)
- Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens (2016) (3)
- Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD 4-Pseudomonas exotoxin and reverse transcriptase inhibitors ( AIDS / therapeutics / targeted cell killing / virus replication inhibition ) (3)
- Purification of calf thymus RNA polymerase II for in vitro transcription studies. (1990) (3)
- Recombinant immunotoxins for the treatment of cancer (1996) (3)
- Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin. (1990) (3)
- Anti-CD 30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma (2013) (3)
- Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models (2013) (3)
- An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice. (1993) (3)
- Combining anti-CTLA4 with RG7787, an immunotoxin targeting mesothelin, promotes tumor eradication (2015) (3)
- Long Term Results of BL22 (CAT-3888) in Multiply Relapsed Hairy Cell Leukemia. (2009) (3)
- Mechanisms of drug resistance in cancer therapy (1990) (3)
- TGF alpha-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors. (1990) (3)
- Binding and Internalization of 1261-~ 2-Macroglobulin by Cultured Fibroblasts * (2001) (3)
- Stability of the Four 2-(p-nitrobenzyl)-trans-CyDTPA 88Y Complexes (1997) (3)
- Kidney-derived cells show multidrug secretory transport. (1991) (3)
- Guanylate Cyclase in Escherichia coZi (1975) (3)
- Phase II trial of CAT-3888 (BL22) in chemo-resistant hairy cell leukemia (2007) (3)
- Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer—a preclinical study (2022) (2)
- An scFv phage clone that binds to human β2-microglobulin (1999) (2)
- Nonidentity of esterase and neutral protease in rat thyroid. (1965) (2)
- Isolation of receptosomes (endosomes) from human KB cells. (1985) (2)
- Phase I study of mesothelin-targeted immunotoxin LMB-100 in combination with tofacitinib in patients with advanced pancreatobiliary cancer. (2021) (2)
- Abstract 58: Local intratumoral treatment with anti-mesothelin Immunotoxins overcomes resistance to anti-CTLA-4 therapy (2017) (2)
- Additive anti-tumor effect of Avastin and Immunotoxin combination therapy on tumor-bearing mouse models (2005) (2)
- Pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of moxetumomab pasudotox (Moxe), an immunotoxin targeting CD22, in adult patients (Pts) with relapsed or refractory hairy cell leukemia (HCL). (2018) (2)
- Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2 (2018) (2)
- Generation of chimeric toxins. (1992) (2)
- A Recombinant Immunotoxin in Which a Mutant Form of Pseudomonas Exotoxin Is Fused to the Fab Fragment of Monoclonal Antibody B 3 (2)
- 16 – Expression, Amplification, and Transfer of DNA Sequences Associated with Multidrug Resistance (1988) (2)
- GPC1-targeted immunotoxins inhibit pancreatic tumor growth in mice via depletion of short-lived GPC1 and downregulation of Wnt signaling. (2022) (2)
- Regulation of gene expression in Escherichia coli by cyclic AMP. (1971) (2)
- Expression Profile of Saccharide Epitope CaMBr1 in Normal and Neoplastic Tissue from Dogs, Cats, and Rats: Implication for the Development of Human-derived Cancer Vaccines (1999) (2)
- Retroviral transfer of multidrug transporter to murine hematopoietic stem cells. (1998) (2)
- Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system. (1999) (2)
- Transfer of the MDR1 gene into haematopoietic cells. (1996) (2)
- Nature and intracellular location of the product of the src gene of avian sarcoma virus. (1980) (2)
- A versatile method for the coupling of protein to DNA: synthesis of alpha 2-macroglobulin-DNA conjugates. (1983) (2)
- Abstract 2566: Combination of taxanes with mesothelin-targeted immunotoxin RG7787 induces synergistic killing of pancreatic cancer (2015) (2)
- Immunotoxins and Endocytosis (1987) (2)
- Crystal structure of the catalytic domain of Pseudomonas aeruginosa exotoxin A complexed with an NAD analogue: implications for the activation process and for ADP-ribosylation (1996) (2)
- 125 I-labeled Anti-Epidermal Growth Factor Receptor-vIII Single-Chain Fv Exhibits Specific and High-Level Targeting of Glioma Xenografts 1 (1999) (2)
- Cytotoxic effect of a fusion protein from transforming growth factora andPseudomonas exotoxin on rat and human bladder carcinoma cells in vitro (2005) (2)
- Membrane vesicles from multidrug-resistant human carcinoma cells contain a specific 150,000-170,000 dalton protein detected by photoaffinity labeling (1986) (2)
- Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase. (1981) (2)
- The improvement of an anti-CD 22 immunotoxin (2011) (2)
- Phase I study of mesothelin-targeted immunotoxin LMB-100 in combination with tofacitinib in persons with pancreatobiliary cancer or other mesothelin expressing solid tumors. (2021) (2)
- Identification of Novel Cancer Target Antigens Utilizing EST and Genome Sequence Databases (2005) (2)
- CD22 Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia. (2009) (2)
- Targeted Toxin Hybrid Proteins (1999) (2)
- Interim Phase I Results of Recombinant Immunotoxin HA22 in Patients with Hairy Cell and Chronic Lymphocytic Leukemias (2008) (2)
- Targeting CD22 in Childhood B-Precursor Acute Lymphoblastic Leukemia (Pre-B ALL): Pre-Clinical Studies and Phase I Trial of the Anti-CD22 Immunotoxin CAT-3888 (BL22). (2007) (2)
- A Divalent Immunotoxin Formed by the Disulfide Bond between Hinge Regions of Fab Domain (2001) (2)
- [30] Cell transformation (1979) (2)
- Generation of a Transgenic BALB/c Mouse Line With Selective Expression of Human Mesothelin in Thyroid Gland: Application in Mesothelin-targeted Immunotherapy (2019) (2)
- Advances in Brief Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma 1 (2000) (1)
- Ultrastructural Localization ofTubulin in Cultured Fibroblasts (1980) (1)
- A preclinical evaluation of mesothelin-specific tumor imaging using 111In-CHX-A"-MORAb-009, a chimeric monoclonal antibody (2010) (1)
- Binding and internalization of alpha 2-microglobulin by cultured fibroblasts. Effects of monovalent ionophores. (1982) (1)
- C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes (2022) (1)
- Receptor-mediated endocytosis of alpha 2-macroglobulin: solubilization and partial purification of the fibroblast alpha 2-macroglobulin receptor. (1983) (1)
- Negative Minimal Residual Disease Associated with Extended Response to Moxetumomab Pasudotox in Patients with Relapsed/Refractory Hairy Cell Leukemia: Long-Term Follow-up of Bone Marrow Immunohistochemistry Analyses from a Phase 1 Study (2017) (1)
- The 1971 nobel prize for physiology or medicine. (1971) (1)
- Abstract PR07: Phase I/II study of mesothelin-targeted immunotoxin LMB-100 with nab-paclitaxel for patients with advanced pancreatic adenocarcinoma (2019) (1)
- An NIH Career: from Bedside to Basic Research and Back (2005) (1)
- Long term follow-up of BL22 in cladribine-resistant hairy cell leukemia (2004) (1)
- A combinatorial immunotherapy for malignant brain tumors: D2C7 immunotoxin and immune checkpoint inhibitors. (2017) (1)
- The Multidrug Resistance Phenotype in Mutant Human Carcinoma Cells : Cytochemical Detection of Altered Accumulation and Efflux of Daunomycin. (1986) (1)
- Improved design of Pseudomonas exotoxin A-based immunotoxins (2007) (1)
- IL-4 receptors on human tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein. (2002) (1)
- Epitope Blocking: Positive and Negative Effects on the Biodistribution of 125I‐Labeled Anti‐Tac Disulfide‐stabilized Fv Fragment of Two Antibodies against Different Epitopes of the Circulating Antigen (1998) (1)
- Docetaxel in adjuvant therapy of breast cancer : results of the TAXIT 216 multicenter phase III trial ” (2008) (1)
- Cytotoxic activity of the low-immunogenic anti-mesothelin immunotoxin RG7787 in pancreatic cancer cells (2014) (1)
- Immunotoxin Therapy for Brain Tumors (2017) (1)
- Analysis of glycoproteins in cancers and normal tissues reactive with monoclonal antibodies B3 and B1. (2000) (1)
- The Internalization of Insulin and Other Hormones by Fibroblastic Cells (1981) (1)
- The Human Multidrug Resistance ( mdrl ) Gene cDNA (2001) (1)
- INTERLEUKIN-13 RECEPTORS ON HUMAN PROSTATE CARCINOMA CELL LINES REPRESENT A NOVEL TARGET FOR A CHIMERIC PSEUDOMONAS EXOTOXIN PROTEIN COMPOSED OF IL-13 AND A MUTATED FORM OF (1997) (1)
- Inhibition by bacitracin of high affinity binding of 125I-alpha 2M to plasma membranes. (1981) (1)
- A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors. (1999) (1)
- Abstract 59: Engineering glypican-3 targeting immunotoxins for the treatment of liver cancer (2017) (1)
- Phase I trial of recombinant immunotoxin anti-Tac -PE38 in patients with hematologic malignancies (1998) (1)
- Identification of Novel Human CTL Epitopes and TheirAgonist Epitopes ofMesothelin (2005) (1)
- Phase I study of mesothelin-targeted immunotoxin LMB-100 given as a long infusion with or without nab-paclitaxel. (2020) (1)
- DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH NICOTINAMIDE AND AMP (1995) (1)
- Pre-clinical studies and phase I clinical trial of the anti-CD22 immunotoxin CAT-3888 (BL22) for pediatric acute lymphoblastic leukemia (ALL) (2007) (1)
- Moxetumomab pasudotox and minimal residual disease in hairy cell leukemia. (2015) (1)
- Molecular Remissions with Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox Are Associated with Improved Complete Remission Durations during Phase I and III Testing (2018) (1)
- Endocannabinoids as emerging suppressors of angiogenesis and breast tumor growth and metastatic spreading ” (2008) (1)
- ANTIBODY DERIVATIVES AS NEW THERAPEUTICS FOR HEMATOLOGIC MALIGNANCIES Immunotoxins for leukemia (2014) (1)
- Binding to erbB 2 Disulfide-stabilized Fv Immunotoxin with Improved Antigen Pharmacokinetics and Antitumor Activity of a Bivalent Updated (1999) (1)
- Recombinant toxins: New and therapeutic agents for cancer (1993) (1)
- Abstract 4595: Moxetumomab pasudotox spares CD4 and CD8 lymphocytes in multiply relapsed hairy cell leukemia patients, while prospective trials of first, second, and later lines of purine analogs show increasing toxicity (2017) (1)
- Resolution of Hairy Cell Leukemia Minimal Residual Disease by Both BRAF and Clone-Specific Real-Time Quantitative PCR (RQ-PCR) After Treatment with Moxetumomab Pasudotox. (2012) (1)
- Effect of mAb B3 and paclitaxel doses on accumulation and penetration of B3 into tumor (2013) (1)
- MA12.11 Anti-Tumor Efficacy of Mesothelin Targeted Immunotoxin LMB-100 Plus Pembrolizumab in Mesothelioma Patients and Mouse Models (2019) (1)
- Addendum to article [21] (1983) (1)
- Nucleotide sequence of a collagen cDNA-fragment coding for the carboxyl end of pro alpha 1(I)-chains. (1980) (1)
- Cell culture (2021) (0)
- Preparations and procedures for clones that contain with multidrug resistance-associated, dna sequences in human cells. (1987) (0)
- Serial fractional doses of mAb B3 and paclitaxel improve accumulation and penetration of B3 due to apoptosis of tumor cells (2014) (0)
- Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models (2023) (0)
- Recombinant immunotoxins: new therapeutic agents for cancer treatment. (1993) (0)
- Gene expression profile analysis of pituitary adenomas developed by HMGA transgenic mice ” (2007) (0)
- Selective Effects of MgCl , and Temperature on the Initiation of Transcription at Zac , gal , and X Promoters (2002) (0)
- Structure of mesothelin and therapeutic antibody complex (2012) (0)
- Immunotoxin and bcl-2 inhibitor combination therapy targeting chondroitin sulfate proteoglycan 4. (2017) (0)
- Immunoconjugates with high binding affinity (2000) (0)
- Abstract 5440: Activity of mesothelin-targeted immunotoxin RG7787 against triple-negative breast cancer (2014) (0)
- Early phase I results of recombinant immunotoxin HA22 in patients with B-cell leukemia (2008) (0)
- Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies (2014) (0)
- Pooled safety summary for patients treated with the CD22-directed cytotoxin moxetumomab pasudotox-tdfk. (2019) (0)
- Abstract 3277: Optimized treatment schedule with the new generation CD22-targeting immunotoxin LMB11 induces near MRD-negativity in an ALL mouse model (2015) (0)
- 5-Azacytidine Prevents Relapse from Discrete Bone Marrow Sites in Leukemia Xenografts Treated with CD22-Targeting Immunotoxin Moxetumomab Pasudotox (2016) (0)
- Decreased Expression of Diphthamide Genes Is Responsible for the Resistance to the Anti-CD22 Immunotoxin Moxetumomab Pasudotox (m. pasudotox) in Acute Lymphoblastic Leukemia (ALL)/Non-Hodgkin Lymphoma (NHL) Cell Lines. (2012) (0)
- Immunogenic peptides and use procedures for (2007) (0)
- Immunotoxin Activity Against B-Lineage Leukemia and Lymphoma Is Exposure Time Dependent: Implications for Trial Design (2015) (0)
- Abstract CN07-03: Recombinant immunotoxins for hematologic malignancies (2019) (0)
- Specific chemical proteins of the il-13 receptor, and its uses. (1996) (0)
- Page-4, a gage-like gen on the x-chromosome that is expressed by neoplastic prostate, testis, and uterus, and its applications (1999) (0)
- Anti-mesothelin immunotoxin induces mesothelioma eradication, anti-tumor immunity, and the development of tertiary lymphoid structures. (2022) (0)
- Regulatory T Cells IL-2 Nonresponsive Subset of Human Fc Receptor-Like 3 Protein Expressed on (2009) (0)
- 18 – CD4-PE40—A Chimeric Toxin Active against Human Immunodeficiency Virus (HIV)-Infected Cells (1991) (0)
- PatientsImmunotoxins for the Treatment of Cancer Exotoxin (PE38) Used to Make Pseudomonas Associated with a Truncated Form of Characterization of the B Cell Epitopes (2006) (0)
- Systemic immune changes accompany combination treatment with immunotoxin LMB‐100 and nab‐paclitaxel (2022) (0)
- Recombinant antibody-based molecular therapeutics for brain tumor immunotherapy (2007) (0)
- Investigation of {alpha}v{beta}3 expression on neovasculature as a predictive marker of therapeutic response (2009) (0)
- Role of HLA-DP in the Presentation of Epitopes from the Truncated Bacterial PE38 Immunotoxin (2016) (0)
- Durability of complete remission by moxetumomab pasudotox (HA22 or CAT-8015) assessed by clone-specific real-time quantitative PCR (RQ-PCR). (2012) (0)
- Optimization of MORAb-009 dose to block shed antigen in circulation and produce high tumor to background ratios of In-111 MORAb-009 (2010) (0)
- Anticorps anti-mesotheline (2010) (0)
- Brief Summary of the Third Joint Meeting of the United States-Japan Cooperative Cancer Research Program on Cell Interactions and Cancer (1982) (0)
- Abstract 4505: Anti-tumor activity in pancreatic cancer of a low immunogenic and clinically optimized anti-mesothelin immunotoxin RG7787 (2014) (0)
- Pseudomonas exotoxin mutated with reduced antigenicity (2006) (0)
- Chemosensitization of transgenic mice expressing the human mdr1 gene in bone marrow (1991) (0)
- Cytotoxicity of TGF alpha-PE40 and correlation to expression of epidermal growth factor receptor. (1995) (0)
- Pseudomonas exotoxin improved with reduced immunogenicity (2010) (0)
- Anti-CD22 antibodies with increased affinity for the leukemic cells expressing CD22. (2002) (0)
- Expression of a multidrug-resistance gene in human tumors and tissues ( cancer chemotherapy / doxorubicin / vinblastine ) (0)
- Cyclic AMP. (1972) (0)
- Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A. (2001) (0)
- Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits (2019) (0)
- Abstract 4356: Cytotoxicity of the anti-CD22 immunotoxin HA22 against pediatric acute lymphoblastic leukemia (ALL) (2010) (0)
- A versatfie method for the coupling of protein to DNA: synthesis of armacroglobulin-DNA conjugates (2004) (0)
- Gene Expression and Detection (2003) (0)
- Molecular mechanisms of insulin resistance : role of endocannabinoid system in the regulation of glucose metabolism and insulin action ” (2007) (0)
- Rat Vascular Smooth Muscle and Endothelial Cells (2005) (0)
- LL2-Fab' Induce Regression of Subcutaneous Human B-Cell Lymphoma in Mice1 (2006) (0)
- Advances in Brief XAGE-1 , A New Gene That Is Frequently Expressed in Ewing ’ s Sarcoma 1 (2000) (0)
- Rate-limiting Step for Toxicity of Pseudomonas Exotoxin 21793 (2001) (0)
- ARB Protection Against Podocyte-Induced Sclerosis is Podocyte AT 1-Independent . Short title : Podocyte AT 1 and Glomerulosclerosis (2010) (0)
- Efficient methods for detectable expression nichtselektierbarer gene. (1990) (0)
- Transgenic Mice Carrying the Human MDR 1 Gene: Reliable In Vivo Probes to Examine Multidrug Resistance (1992) (0)
- Recombinant Pseudomonas toxin Construction of an effective immunotoxin with few side effects. (1987) (0)
- 1218 MSLN-targeted immunotoxin LMB-100 induces development of tertiary lymphoid structures and tumor regressions of orthotopic mesothelioma (2022) (0)
- Anti-Mesothelin Immunotoxin and Immune Suppression Major Cancer Regressions in Mesothelioma After Treatment with an (2013) (0)
- Recombinant disulfide stabilized polypeptides binding specificity (1994) (0)
- MDR 1 Gene Transfer to Hematopoietic Cells (1999) (0)
- 5.21 ROR1-Immunotoxin as a Potential Therapeutic Agent for Certain Human B-cell Malignancies (2011) (0)
- Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck ” (2008) (0)
- Immunoconjugates having mound binding affinity (2000) (0)
- 312 The prognostic role of mesothelin expression and its association with KRAS mutation in advanced lung adenocarcinoma (2014) (0)
- Regulation of gene expression by cyclic AMP in Escherichia coli. (1973) (0)
- Smooth Muscle Cells (2005) (0)
- Phase 1 trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox combined with rituximab for relapsed/refractory hairy cell leukemia. (2021) (0)
- Pooled Safety Summary for Patients Treated with the CD22-Directed Cytotoxin Moxetumomab Pasudotox-tdfk (2019) (0)
- Combining the Recombinant Immunotoxin SS1P With the BH3-MIMETIC ABT-737 Induces Cell Death in Pancreatic Cancer Cells (2012) (0)
- Synergistic AntitumorActivity ofTaxol and Immunotoxin SS1P inTumor-BearingMice (2006) (0)
- Effect of tumor-penetrating peptide iRGD on uptake of In-111 labeled B3, anti-Ley mAb in PC-3 tumor (2013) (0)
- Abstract A157: Multi-kinase inhibitor H89 enhances activity of pseudomonas exotoxin-based immunotoxins targeting acute lymphoblastic leukemia (2015) (0)
- NEXT-GENERATION RECOMBINANT IMMUNOTOXINS FOR GLIOBLASTOMAS AND MELANOMAS TREATMENT (2014) (0)
- 1108. High Rate of Anti-Tumor Immune Responses in a Phase 1 Clinical Trial of Adenoviral-Interferon-Beta Gene Transfer for Malignant Mesothelioma (MM) and Malignant Pleural Effusions (MPE) (2006) (0)
- Synergistic Anti-tumor Activity of Local SS1P with Systemic CTLA-4 Blockade Causes Complete Regression of Both Injected and Un-injected Tumors in Mice (2017) (0)
- Abstract A142: Anti-mesothelin immunotoxins induce markers of immunogenic cell death and when injected locally into AE17M mesothelioma tumors enhance the effect of CTLA-4 blockade (2019) (0)
- New genes involved in the neoplastic transformation of the thyroid gland (2006) (0)
- (cid:97) -Galactosidase A deficient mice: A model of Fabry disease (1997) (0)
- Abstract 2586: Bortezomib reduces preexisting antibodies to recombinant immunotoxins in mice (2014) (0)
- Gene therapy use of genschmelzen for genetic and acquired disorders (1989) (0)
- N001 Generation of a transgenic model of inducible cardiomyocyte death by immuno-mediated cell targeting (2009) (0)
- Abstract 547: Recombinant immunotoxins targeting B-cell maturation antigen induce complete responses in bone marrow myeloma mouse model (2019) (0)
- DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH BETA-TAD (1996) (0)
- IDENTIFICATION OF TWO COLLAGEN RNAS LARGER THAN α1 AND α2 COLLAGEN MRNAS WHICH ARE DECREASED IN TRANSFORMED CELLS (1979) (0)
- 557 The epitope-enhanced TARP peptide can induce specific T cells that can recognize wild-type TARP tetramer by either peptide or peptide-pulsed DC vaccination in patients with prostate cancer (2022) (0)
- Clinical Applications of Gene Therapy in Cancer: Modification of Sensitivity to Therapeutic Agents (2002) (0)
- Two novel lysosomal membrane glycoproteins identified by monoclonal antibodies (1985) (0)
- IRTA2 Protein on Lymphoma Cell Lines and Hairy Cell Leukemia Cells Detected by Novel Monoclonal Antibodies. (2004) (0)
- Doctorate Program in Molecular Oncology and Endocrinology (2006) (0)
- Immunotoxin and paclitaxel synergy results from a decrease in shed target antigen levels in the extracellular space of tumors (2008) (0)
- vascular smooth muscle cells Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating (2011) (0)
- Regulation of Gal Messenger Ribonucleic Acid Syuthesis in (2011) (0)
- THERAPIE CELLULAIRE N 001 GENERATION OF A TRANSGENIC MODEL OF INDUCIBLE CARDIOMYOCYTE DEATH BY IMMUNO-MEDIATED CELL TARGETING (2009) (0)
- NGEP-L, a prostate specific plasma membrane protein, is a new target for prostate cancer immunotherapy (2007) (0)
- Abstract No. 334 Drug distribution maps with CT after direct co-injection with contrast agent in ex vivo tissue (2022) (0)
- Addition of a heparin binding site to a chimeric toxin confers heparin modulation and improves its cytotoxicity to tumor and proliferating vascular smooth muscle cells (1993) (0)
- THE USE OF TRANSFORMED FIBROBLASTIC CELLS AS A MODEL FOR DIFFERENTIATION (1978) (0)
- ProteinKinase InhibitorH 89 Enhances theActivity of Pseudomonas ExotoxinA – Based Immunotoxins (2016) (0)
- Repression of @ Galactosidase Synthesis by Glucose in Phosphotransferase Mutants of Escherichia coli (2003) (0)
- PATEGeneClustersCodeforMultiple,SecretedTFP/Ly-6/uPAR ProteinsThatAreExpressedinReproductiveandNeuron-rich TissuesandPossessNeuromodulatoryActivity * (2008) (0)
- Generation and Optimization of a Chimeric Antigen Receptor Against CD22: A New Immunotherapeutic Agent for Treating B Lineage Leukemia and Lymphoma (2011) (0)
- Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies (2023) (0)
- Abstract 1767: Synergy between intratumoral immunotoxin and systemic anti-CTLA-4 promotes massive inflammation and leads to complete regression of tumors in mice (2018) (0)
- Isolation and characterization of genomic DNA coding for alpha 2 type I collagen. (1980) (0)
- Mesothelin antibodies and methods to elicit a potent antitumor activity (2013) (0)
- Morphologic studyoftheinternalization ofalysosomal enzyme bythemannose6-phosphate receptor incultured Chinese hamster ovarycells (1981) (0)
- Phorbol esters induce transient int of unoccupied epidermal growth fa (KB cells/protein kinase C/transreticular Golgi/recycling/phospho) (2016) (0)
- c-erbB-2 and human cancer. (1993) (0)
- Biological activity of a transforming growth factor-alpha-Pseudomonas exotoxin fusion protein in vitro and in vivo (1991) (0)
- Abstract 3103: The reduced immunogenicity anti-mesothelin immunotoxin RG7787 in combination with nab-paclitaxel has significant anti-tumor efficacy against primary mesothelioma cell lines and patient derived mesothelioma tumor xenografts (2016) (0)
- Abstract 4334: Identification and elimination of T-cell epitopes in recombinant immunotoxins used to treat cancer. (2013) (0)
- Stimulation of Glucose Oxidation in Thyroid by Thyroid Stimulating Hormone (TSH) and Other Substances. (1961) (0)
- Abstract 68: Methotrexate prevents primary immune responses against recombinant immunotoxin in murine models (2017) (0)
- to Protein Therapeutics in Murine Hosts Tofacitinib Suppresses Antibody Responses (2014) (0)
- Oral Free Communications (2004) (0)
- Abstract 5428: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin (2014) (0)
- Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin (2022) (0)
- A New High Activity Anti-CD22 Chimeric Antigen Receptor (CAR) Targeting B Cell Leukemia. (2012) (0)
- 283 Targeting of human glioma xenografts with an anti-EGFRvIII minibody (MR1-1scFv-CH3) (2004) (0)
- Erratum: (Cancer Research (July 1, 1994) (3460-3467)) (1994) (0)
- Abstract P5-08-03: Intraductal administration of a Transferrin Receptor-directed immunotoxin eliminates ductal carcinoma in situ in preclinical mammary in-duct (MIND) models of breast cancer (2022) (0)
- THE ROLE OF THE RECEPTOSOME IN RECEPTOR-MEDIATED ENDOCYTOSIS (1981) (0)
- Immunotoxins for Treating Cancer and Autoimmune Disease (2019) (0)
- Synergistic effect of Taxol and enhanced delivery effect of pulsed high intensity focused ultrasound (P-HIFU) when combined with radioimmunotherapy (2009) (0)
- IL‐2 non‐responsive subset of human natural regulatory T cells expresses Fc receptor‐like 3 protein (2008) (0)
- Monoclonal antibodies and immobilized antibodies (1987) (0)
- Human Carcinoma Interleukin 4-Toxin in Mice with Interleukin 4 Receptor-bearing Increased Antitumor Activity of a Circularly Permuted Updated (2006) (0)
- Human bispecific EGFRvIII and CD3 antibody engaging molecules (2014) (0)
- MORPHOLOGIC ASPECTS OF CANCER : IMMUNOTOXINS AND MULTIDRUG RESISTANCE (1987) (0)
- Antibody–Toxin and Growth Factor–Toxin Fusion Proteins (2002) (0)
- Multiple proteases are involved in mesothelin shedding by cancer cells (2020) (0)
- Receptor Gene in Human Squamous Carcinoma Cell Lines High Incidence of Amplification of the Epidermal Growth Factor Updated (2006) (0)
- Circularly permuted ligands and chimeric molecules circularly permuted. (1995) (0)
- Abstract 5357: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin for cancer therapy (2015) (0)
- Mesothelin-fc fusion protein detection using a novel microelectronic acoustic sensor platform (2007) (0)
- Abstract B37: Mesothelin-targeted immunotoxin RG7787 (LMB-100) preferentially depletes secreted proteins and short-lived intracellular proteins to augment tumor cell killing by taxanes (2016) (0)
- A recombinant Pseudomonas exotoxin comprising ADP ribosylating activity and lacking all or part of domain II from d (1999) (0)
- Synergistic effect of Taxol and additive effect of Avastin when combined with radioimmunotherapy (2010) (0)
- Abstract 2976: Engineering next-generation anti-CD25 immunotoxins with improved cytotoxic activity and low immunogenicity (2016) (0)
- recombinant polypeptide fragments stabilized disulfide bonds, which have binding specificity. (1994) (0)
- Doctorate Program in Molecular Oncology and Endocrinology XVIII cycle-2002–2006 Coordinator: Prof. Giancarlo Vecchio “NOVEL MECHANISMS RESPONSIBLE FOR CONTROLLING GLUCOSE-INDUCED INSULIN SECRETION IN PANCREATIC BETA-CELLS” (2006) (0)
- Abstract A081: Phase I study of mesothelin-targeted immunotoxin LMB-100 given as a long infusion (2019) (0)
- Delivery systems for the MDR 1 gene (2013) (0)
- Crystal Structure of Msln7-64 MORAb-009 FAB complex (2012) (0)
- Recombinant disulfide polypeptide fragments with binding (1994) (0)
- Vincenzo Macchia and Ira Pastan TO THYROID-STIMULATING HORMONE Action of Phospholipase C on the Thyroid : ABOLITION OF THE RESPONSE (2001) (0)
- Abstract 3504: Generation and optimization of a chimeric antigen receptor against human CD22: A new immunotherapeutic agent for adoptive immunotherapy (2012) (0)
- HA22 (R490A) is a recombinant immunotoxin with increased anti-tumor activity and therapeutic index (2004) (0)
- NUCLEOTIDE SEQUENCE AND STRUCTURAL FEATURES OF THE COMMON REGION OF AVIAN SARCOMA VIRUS (1980) (0)
- Abstract 3813: MPF as a monitoring biomarker for a mesothelin-targeted therapy against malignant mesothelioma and other cancer (2017) (0)
- TARP TETRAMER BY EITHER PEPTIDE OR PEPTIDE-PULSED DC VACCINATION IN PATIENTS WITH PROSTATE CANCER (2022) (0)
- The HLA-DRB1*11 Antigen Is Preferentially Expressed in Hairy Cell Leukemia, Particularly in Patients Who Had Hemolytic Uremic Syndrome with Recombinant Immunotoxin BL22. (2012) (0)
- Modulation by GTP/ATP ratio of the phosphorylation level of P-glycoprotein in plasma membrane vesicles from KB-V-1 multidrug resistant cells: 1 (1994) (0)
- Improved antitumor activity of a recombinant anti-LewisY immunotoxin not requiring proteolytic activation (cancer therapy/Pseudomonas exotoxin/monoclonal antibody Bi Fv fragment/disulfide-stabilized Fv fragment/protein engineering) (2016) (0)
- Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts. (1985) (0)
- Abstract 5606: Preclinical and clinical development of anti-CD25 recombinant immunotoxin LMB-2 in combination with chemotherapy for the treatment of adult T-cell leukemia (2010) (0)
- Abstract 743: Tyrosine kinase discoidin domain receptor-1 (DDR1) regulates cytotoxicity of recombinant immunotoxin for cancer therapy (2016) (0)
- recombinant exoprotein A. bound to Pseudomonas aeruginosa type 5 and type 8 capsular polysaccharides vaccines composed of Staphylococcus aureus Laboratory and clinical evaluation of conjugate (2013) (0)
- ScFv molecules against EGFRvIII with improved cytotoxicity and yield, based on immune toxins, and methods for their use (2001) (0)
- Podocytes are lost from glomeruli before completing apoptosis. (2022) (0)
- Activity of a Chick Collagen Gene in Heterologous and Homologous Cell-Free Extracts (1984) (0)
- Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases (2006) (0)
- Immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating rapamycin (2017) (0)
- Production of stable scFv by mutation of the unusual amino acids at the framework region (1998) (0)
- ROLE OF CYCLIC AMP IN REGULATION OF GENE EXPRESSION A Positive Element in Gene Expression (0)
- CYTOTOXICITY STUDIES OF K1-LYSPE38QQR, AN IMMUNOTOXIN FOR THE TREATMENT OF OVARIAN CANCER AND MALIGNANT MESOTHELIOMAS (1997) (0)
- Roleofa Low-pHEnvironment inAdenovirus Enhancement ofthe Toxicity ofa Pseudomonas Exotoxin-Epidermal GrowthFactor (1984) (0)
- 2410 An animal model for autonomic neuropathy in transgenic mice (1997) (0)
- INTERACTION BETWEEN THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR AND PDK 1 AS POTENTIAL THERAPEUTIC TARGET IN NEOPLASTIC CELLS ” (2007) (0)
- Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance (1991) (0)
- Anti-CD22 antibodies and inmunocongujados mutated. (2004) (0)
- activity against CLL and diminished animal toxicity A protease-resistant immunotoxin against CD22 with greatly increased (2013) (0)
- 941 Reverse transcription of a non-viral RNA template by the human hepatitis B-virus polymerase (2003) (0)
- Combining the recombinant immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells (2013) (0)
- Role of cell surface carbohydrates and proteins in cell behavior: Studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant (cell surface glycoproteins/membrane mutant/growth control/phenotypic transformation/3T3 Balb cells) (2016) (0)
- Su.127. Eradication of Tumor Colonization and Invasion By a B-Cell Specific Immunotoxin in a Murine Model for Human Primary Intraocular Lymphoma (Piol) (2006) (0)
- Tumor Targeting by Antibody-Drug Conjugates (2019) (0)
- Reduction de la toxicite animale non specifique des immunotoxines par mutation des regions d'infrastructure de fv pour reduire le point isoelectrique (2001) (0)
- Abstract C163: Understanding the mechanism for synergistic anti-tumor activity of a meosthelin-targeted immunotoxin and taxanes (2015) (0)
- Abstract 5567: hYP218 CAR-T cells targeting a membrane-proximal epitope of mesothelin are highly effective against mesothelin expressing cancers (2022) (0)
- A method for preparing a modified Pseudomonas exotoxin and containing the targeting carrier-toxin conjugates and immunotoxins + (1989) (0)
- Composition pharmaceutique pour le traitement de la pharmacodependance (2004) (0)
- Abstract 1290: Actinomycin D enhanced immunotoxin RG7787 killing of cancer cells (2016) (0)
- After Breast Cancer Chemotherapy Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells (2013) (0)
- Humoral Immune Response toMesothelin inMesothelioma and Ovarian Cancer Patients (2005) (0)
- A tri-specific killer engager against mesothelin targets NK cells towards lung cancer (2023) (0)
- Activity of a recombinant fusion protein between transforming growth factor type a and Pseudomonas toxin ( cancer / receptors / epidermal growth factor / A 431 cells / immunototins ) (0)
- Abstract 5482: Combining the anti-mesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cell lines. (2013) (0)
- Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma (2015) (0)
- BIODISTRIBUTION OF MONOCLONAL ANTIBODY K1 IN NUDE MICE BEARING HUMAN CARCINOMA XENOGRAFTS EXPRESSING MESOTHELIN (1997) (0)
- Single-Dose Intrapleural IFN-B GeneTransfer forMalignant PleuralMesotheliomaandMetastatic Pleural Effusions : HighRate ofAntitumor ImmuneResponses (2007) (0)
- BL22: A Milestone in Targeting CD22 (2017) (0)
- Abstract 5490: The cytotoxic activity of the anti-mesothelin immunotoxin SS1P is enhanced by the PKC inhibitor enzastaurin. (2013) (0)
- A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice (2014) (0)
- Pegylation of linkers enhances the antitumor effect and reduces the immunoconjugates tokcitet (2001) (0)
- Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial (2016) (0)
- Regulation of P-Galactosidase Synthesis in Escherichia coli by Cyclic Adenosine 3’, 5’-Monophosphate (2003) (0)
- [Gene cloning, expression of fusion protein TGF alpha-PE 40 and its inhibition activity on cancer cell growth]. (1993) (0)
- Abstract 4571: Autologous TARP peptide vaccination is associated with slowing in PSA velocity and a decrease in tumor growth rate in patients with Stage D0 prostate cancer. (2013) (0)
- Molecular approaches for circumvention of multidrug resistance mediated by P-glycoprotein: 158 (1994) (0)
- Pulsed-high intensity focused ultrasound (P-HIFU) enhances delivery of radiolabeled monoclonal antibody B3 to A431 tumor in nude mice (2007) (0)
- CD22-Bearing Cells and Tumors Recombinant RFB4 Immunotoxins Exhibit Potent Cytotoxic Activity for (2013) (0)
- Large Molecule Therapeutics Ef fi cacy of RG 7787 , a Next-Generation Mesothelin-Targeted Immunotoxin , against Triple-Negative Breast and Gastric Cancers (2014) (0)
- Interactions Between Immunotoxins and the Plasma Membrane (2018) (0)
- Antitumor Activity Of Recombinant Inumunotoxin Anti-tac(fv)-pe38 (lmb-2) In Patients With Hematologic Malignancies (1999) (0)
- Assessment of therapeutic response with In-111 labeled peptidomimetic antagonist to {alpha}v{beta}3 receptor (2007) (0)
- MORPHOLOGIC ASPECTS OF THE CELL BIOLOGY OF MULTIDRUG RESISTANCE AND IMMUNOTOXINS. (1988) (0)
- Cancer Therapy : Preclinical Synergistic Antitumor Activity of Anti-CD 25 Recombinant Immunotoxin LMB-2 with Chemotherapy (2011) (0)
- Isolation and characterization of overlapping genomic clones covering the chicken a 2 ( type I ) collagen gene ( intervening sequences / recombinant DNA ) (0)
- CD30 as Target for Radioimmunotherapy (RIT) of Lymphoma. (2005) (0)
- Lines Reversal of Multidrug Resistance in Human and Murine Cell Cellular and Biochemical Characterization of Thioxanthenes for Updated (2006) (0)
- Effect of change in pI produced by chelator conjugation to mAb on tumor and organ uptake of In-111 labeled mAb (2010) (0)
- VivoPartial Reduction in Regulatory T Cells In Metastatic Melanoma Induces a Selective Immunotoxin, LMB-2, to Patients with Administration of a CD25-Directed (2007) (0)
- Immunotoxin-mediated conditional disruption of specffic neurons in transgenic mice ( recombinant immunotoxin / dopamine P-hydroxylase / interleukin 2 receptor / cell ablation ) (2005) (0)
- sensitive tissue must be binding of the hormone to some cellular constituent. To delineate this interaction we have studied the effects of thyroid-stimulating hor- mone (TSH) on thyroid slices and of insulin on skeletal muscle. Tissues that were (2016) (0)
- Abstract 3247: Granulocytic MDSCs (CD11b+CD15+CD14-HLADR-) in peripheral blood of mesothelioma patients are elevated and suppress T cell proliferation and function via reactive oxygen species (2016) (0)
- Long term follow-up of BL22 in cladribine-resistant hairy cell leukemia. (2004) (0)
- LMB-2 Toxicity of Immunotoxin Anti-Tac ( Fv )-PE 38 , Cells Protects Against the Nonspecific Liver Produced by Kupffer α Inhibition of TNF-Pastan (2000) (0)
- Pharmacokinetics of recombinant immunotoxin BL22 during phase II testing in chemo-resistant hairy cell leukemia (2008) (0)
- from patients with chronic lymphocytic leukemia monoclonal antibody to the interleukin-2 receptor kill malignant cells Recombinant toxins containing the variable domains of the anti-Tac (2011) (0)
- Transcription of the Chicken a 2 ( Type I ) Collagen Gene by Homologous Cell-free Extracts (2001) (0)
- Abstract A67: The mTOR inhibitor, everolimus, enhances the cytotoxicity of pseudomonas-based immunotoxins: Mechanistic insights (2016) (0)
- Prolonged Half‐life of Recombinant Immunotoxins in Mice by Adding an Albumin Binding Domain (2017) (0)
- Gordon Tomkins (1975) (0)
- Tumor and organ uptake of 64Cu labeled MORAb-009, an anti-mesothelin antibody by PET Imaging and biodistribution studies (2015) (0)
- A recombinant Pseudomonas exotoxin with modification in the receptor binding domain Ia, the target carrier-toxin conjugate, immunotoxins (1988) (0)
- Anti-immune toxins against human ovarian cancer and methods for their use. (1986) (0)
- Abstract CN07-02: Immunotoxins targeting GPC3 for liver cancer (2019) (0)
- Selectable Markers for Gene Therapy 2 (2003) (0)
- Cell-specific toxicity of a chimeric protein composed of interleukin-6 and Pseudomonas exotoxin (IL6-PE40) on tumor cells (1990) (0)
- Effective Treatment of Drug Resistant Hairy Cell Leukemia by Immunotoxin BL22 (2008) (0)
- An scFv phage clone that binds to human beta2-microglobulin. (1999) (0)
- For the il-13 receptor-specific chimeric proteins and their uses (1996) (0)
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