Ira Tabas
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Ira Tabas's Degrees
- Doctorate Medicine Columbia University
- PhD Biochemistry Columbia University
Why Is Ira Tabas Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ira Tabas is an American molecular biologist who currently serves as Richard J. Stock Professor and Vice-Chair of Research in the Department of Medicine, Professor of Anatomy & Cell Biology at Columbia University in the City of New York, and an endocrinologist affiliated with NewYork–Presbyterian Hospital .
Ira Tabas's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Atherosclerosis--an inflammatory disease. (1999) (9698)
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
- Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress (2011) (2190)
- Macrophages in the Pathogenesis of Atherosclerosis (2011) (2158)
- The response-to-retention hypothesis of early atherogenesis. (1995) (1398)
- Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications (2007) (1220)
- Role of cholesterol and lipid organization in disease (2005) (1159)
- Macrophage death and defective inflammation resolution in atherosclerosis (2010) (1041)
- The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages (2003) (869)
- Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities (2013) (784)
- Recent insights into the cellular biology of atherosclerosis (2015) (752)
- Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis: The Importance of Lesion Stage and Phagocytic Efficiency (2005) (661)
- Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. (2002) (638)
- Macrophage Phenotype and Function in Different Stages of Atherosclerosis. (2016) (635)
- Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) (623)
- Insulin resistance, hyperglycemia, and atherosclerosis. (2011) (606)
- Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. (2011) (587)
- Macrophage autophagy plays a protective role in advanced atherosclerosis. (2012) (505)
- Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis (2009) (472)
- Letter by Williams and Tabas regarding article "atherosclerosis 2005: recent discoveries and novel hypotheses". (2006) (465)
- The role of endoplasmic reticulum stress in the progression of atherosclerosis. (2010) (436)
- The response-to-retention hypothesis of atherogenesis reinforced. (1998) (412)
- Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. (2010) (410)
- Inflammation and plaque vulnerability (2015) (409)
- Monocyte-Macrophages and T Cells in Atherosclerosis. (2017) (405)
- Inflammation and its Resolution as Determinants of Acute Coronary Syndromes (2014) (398)
- Role of endoplasmic reticulum stress in metabolic disease and other disorders. (2012) (390)
- Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. (2005) (389)
- Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. (2009) (388)
- Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor (2005) (357)
- Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. (2009) (340)
- Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. (1998) (322)
- Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe−/− Mice (2008) (315)
- Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH (1998) (306)
- Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair (2010) (303)
- Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. (1996) (299)
- The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein. (1978) (282)
- Efferocytosis in health and disease (2019) (281)
- NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis (2010) (280)
- Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids (2004) (279)
- Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. (2006) (273)
- Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides. (1979) (273)
- An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques (2016) (273)
- Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice (2015) (272)
- Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene* (1996) (269)
- Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain. (1978) (264)
- Adaptive Suppression of the ATF4-CHOP Branch of the Unfolded Protein Response by Toll-Like Receptor Signaling (2009) (260)
- Interleukin 8 Is Induced by Cholesterol Loading of Macrophages and Expressed by Macrophage Foam Cells in Human Atheroma (*) (1996) (260)
- Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase (1998) (251)
- Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice (2009) (238)
- The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein. (1978) (238)
- The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene* (1998) (237)
- Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. (2016) (230)
- Increased CD36 protein as a response to defective insulin signaling in macrophages. (2004) (230)
- Sphingomyelinase Treatment Induces ATP-independent Endocytosis (1998) (210)
- Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-&kgr;B–Mediated Inflammation in Macrophages (2014) (208)
- Mechanisms and consequences of efferocytosis in advanced atherosclerosis (2009) (204)
- Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)* (2011) (199)
- Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway* (2001) (199)
- Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism* (2008) (194)
- Cholesterol in health and disease. (2002) (193)
- Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway* (2000) (187)
- Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages (2017) (187)
- The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides. (1978) (187)
- Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol (2004) (186)
- Accelerated transfer of cholesteryl esters in dyslipidemic plasma. Role of cholesteryl ester transfer protein. (1987) (186)
- Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (1991) (185)
- Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages (2006) (185)
- Preferential ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux from Late Endosomes/Lysosomes* (2001) (184)
- Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution (2018) (181)
- Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance (2018) (177)
- Mechanisms of ER stress-induced apoptosis in atherosclerosis. (2011) (177)
- Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation. (1993) (176)
- Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles (2013) (174)
- Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. (2012) (172)
- Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase α in Mice Decreases Plasma High Density and Very Low Density Lipoproteins* (2004) (168)
- Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress. (2009) (165)
- ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis (2010) (165)
- Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. (2009) (165)
- Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis. (2000) (163)
- Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues. (1980) (162)
- Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. (2013) (156)
- Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K (2009) (156)
- FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. (2012) (155)
- Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis (2018) (154)
- Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis (2003) (154)
- Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway (2014) (152)
- Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. (2016) (149)
- ABCA1-mediated Cholesterol Efflux Is Defective in Free Cholesterol-loaded Macrophages (2002) (148)
- Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages. (1991) (148)
- Nonoxidative modifications of lipoproteins in atherogenesis. (1999) (146)
- The role of non‐resolving inflammation in atherosclerosis (2018) (146)
- Lipoprotein retention--and clues for atheroma regression. (2005) (146)
- Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. (2020) (145)
- Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo (2008) (142)
- Cholesterol and phospholipid metabolism in macrophages. (2000) (141)
- microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis (2017) (139)
- Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size (2002) (139)
- Boosting Inflammation Resolution in Atherosclerosis: The Next Frontier for Therapy. (2017) (138)
- Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet (2009) (135)
- MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation (2016) (134)
- Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression (2008) (134)
- IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. (2008) (132)
- Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2V617F Mice (2018) (130)
- Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase* (2010) (130)
- Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. (1998) (129)
- Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix. (1999) (127)
- The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent* (1996) (126)
- Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis (2018) (122)
- Induction of ER Stress in Macrophages of Tuberculosis Granulomas (2010) (121)
- Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level. (1991) (121)
- Plasma sphingomyelin and subclinical atherosclerosis: findings from the multi-ethnic study of atherosclerosis. (2006) (119)
- Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis (2020) (119)
- MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis (2017) (119)
- Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages (1990) (117)
- Acid Sphingomyelinase-deficient Macrophages Have Defective Cholesterol Trafficking and Efflux* (2001) (116)
- Mechanisms of Fibrosis Development in NASH. (2020) (115)
- Transforming growth factor-beta 1 inhibits scavenger receptor activity in THP-1 human macrophages. (1991) (115)
- Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2). (2018) (112)
- Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate. (1988) (109)
- The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic Plaque Progression (2010) (109)
- Early Embryonic Lethality in Mice with Targeted Deletion of the CTP:Phosphocholine Cytidylyltransferase α Gene (Pcyt1a) (2005) (106)
- MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury (2017) (105)
- Brief Report: Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe−/− Mice Lacking Macrophage Bcl-2 (2009) (105)
- Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. (2013) (104)
- Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. (2019) (104)
- The UPR in atherosclerosis (2013) (103)
- Evidence That the Initial Up-regulation of Phosphatidylcholine Biosynthesis in Free Cholesterol-loaded Macrophages Is an Adaptive Response That Prevents Cholesterol-induced Cellular Necrosis (1996) (102)
- Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. (2012) (101)
- TNFα induces ABCA1 through NF-κB in macrophages and in phagocytes ingesting apoptotic cells (2006) (101)
- Macrophage Apoptosis in Advanced Atherosclerosis (2009) (101)
- The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis (2011) (101)
- InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes (2012) (100)
- Free cholesterol-induced cytotoxicity a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions. (1997) (97)
- CD11c+ Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD4+ T-Cell Priming Efficacy Under Hypercholesterolemic Conditions Associated With Atherosclerosis (2008) (97)
- The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials. (2021) (96)
- Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6 (2005) (95)
- Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor* (2006) (94)
- p53 and atherosclerosis. (2001) (93)
- Direct Observation of Rapid Internalization and Intracellular Transport of Sterol by Macrophage Foam Cells (2005) (93)
- Mechanism of the association of HDL3 with endothelial cells, smooth muscle cells, and fibroblasts. Evidence against the role of specific ligand and receptor proteins. (1984) (93)
- Physiological Regulation of Phospholipid Methylation Alters Plasma Homocysteine in Mice* (2005) (92)
- Minimally Oxidized LDL Offsets the Apoptotic Effects of Extensively Oxidized LDL and Free Cholesterol in Macrophages (2006) (92)
- Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase. (1994) (91)
- siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice (2020) (88)
- Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. (1985) (84)
- Improvement in Lipid and Protein Trafficking in Niemann‐Pick C1 Cells by Correction of a Secondary Enzyme Defect (2010) (84)
- Sitosterol-containing Lipoproteins Trigger Free Sterol-induced Caspase-independent Death in ACAT-competent Macrophages* (2006) (84)
- Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress (2008) (82)
- An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. (2014) (80)
- Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. (2020) (77)
- Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling. (2015) (76)
- Secretory sphingomyelinase. (1999) (75)
- Dendritic cells in atherosclerosis (2013) (75)
- Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency (2014) (75)
- Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis (2021) (75)
- MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity (2018) (73)
- Foam cell-forming J774 macrophages have markedly elevated acyl coenzyme A:cholesterol acyl transferase activity compared with mouse peritoneal macrophages in the presence of low density lipoprotein (LDL) despite similar LDL receptor activity. (1987) (72)
- Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice (2017) (72)
- Unique Cellular Events Occurring during the Initial Interaction of Macrophages with Matrix-retained or Methylated Aggregated Low Density Lipoprotein (LDL) (1999) (71)
- Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis. (2020) (71)
- Apoptosis and efferocytosis in mouse models of atherosclerosis. (2007) (70)
- Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages (1993) (69)
- Pivotal Advance: Macrophages become resistant to cholesterol‐induced death after phagocytosis of apoptotic cells (2007) (69)
- 2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular–Cellular Mechanisms in the Progression of Atherosclerosis (2017) (69)
- Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in Life (2018) (68)
- The Uptake and Degradation of Matrix-bound Lipoproteins by Macrophages Require an Intact Actin Cytoskeleton, Rho Family GTPases, and Myosin ATPase Activity* (2001) (68)
- Role of ERO 1-– mediated stimulation of inositol 1 , 4 , 5-triphosphate receptor activity in endoplasmic reticulum stress – induced apoptosis (2009) (67)
- Human plasma cholesteryl ester transfer protein enhances the transfer of cholesteryl ester from high density lipoproteins into cultured HepG2 cells. (1987) (67)
- The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages (1995) (67)
- The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages (1991) (67)
- Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation. (1986) (66)
- Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content. (1994) (66)
- Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B (2011) (66)
- Association of Plasma Sphingomyelin Levels and Incident Coronary Heart Disease Events in an Adult Population: Multi-Ethnic Study of Atherosclerosis (2010) (62)
- Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is (2000) (60)
- CAMKII&ggr; suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis (2017) (60)
- Pioglitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor-Null Mice (2007) (59)
- Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation. (1993) (59)
- Lack of Association Between Adiponectin Levels and Atherosclerosis in Mice (2010) (59)
- Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A2* (2007) (57)
- Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages* (1998) (57)
- TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. (2006) (56)
- Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment (2012) (56)
- Sphingomyelinase Converts Lipoproteins From Apolipoprotein E Knockout Mice Into Potent Inducers of Macrophage Foam Cell Formation (2000) (53)
- Emerging roles of mitochondria ROS in atherosclerotic lesions: causation or association? (2014) (53)
- The Structure of the Gene for Murine CTP:Phosphocholine Cytidylyltransferase, Ctpct (1997) (52)
- HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis (2019) (52)
- Maladaptive regeneration — the reawakening of developmental pathways in NASH and fibrosis (2020) (50)
- Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function. (2000) (50)
- Stimulation of CTP:Phosphocholine Cytidylyltransferase by Free Cholesterol Loading of Macrophages Involves Signaling through Protein Dephosphorylation (*) (1995) (48)
- LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux (2018) (48)
- C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. (2015) (47)
- Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment. (2000) (45)
- Transcriptional activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct): combined action of upstream stimulatory and inhibitory cis-acting elements. (1999) (44)
- Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance. (2016) (43)
- Efferocytosis induces macrophage proliferation to help resolve tissue injury (2021) (42)
- Calcium signalling and ER stress in insulin resistance and atherosclerosis (2016) (40)
- OLIGOSACCHARIDE PROCESSING DURING GLYCOPROTEIN BIOSYNTHESIS (1979) (37)
- Protein synthesis inhibition in mouse peritoneal macrophages results in increased acyl coenzyme A:cholesterol acyl transferase activity and cholesteryl ester accumulation in the presence of native low density lipoprotein. (1987) (37)
- The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages. (1994) (37)
- The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice (2013) (37)
- Pulling down the plug on atherosclerosis: Finding the culprit in your heart (2011) (36)
- Loss of Subcellular Lipid Transport Due to ARV1 Deficiency Disrupts Organelle Homeostasis and Activates the Unfolded Protein Response* (2011) (36)
- Effects of particle size on cell uptake of model triglyceride-rich particles with and without apoprotein E. (1994) (35)
- Hypercholesterolemia induces T cell expansion in humanized immune mice (2018) (35)
- ACAT Inhibition Reduces the Progression of Preexisting, Advanced Atherosclerotic Mouse Lesions Without Plaque or Systemic Toxicity (2013) (34)
- Cholesteryl ester loading of mouse peritoneal macrophages is associated with changes in the expression or modification of specific cellular proteins, including increase in an alpha-enolase isoform. (1993) (33)
- Atherosclerosis and Inflammation (2002) (32)
- A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins (2014) (32)
- The Cytoplasmic Domain of the Low Density Lipoprotein (LDL) Receptor-related Protein, but Not That of the LDL Receptor, Triggers Phagocytosis* (2003) (31)
- The Binding Activity of the Macrophage Lipoprotein(a)/Apolipoprotein(a) Receptor Is Induced by Cholesterol via a Post-translational Mechanism and Recognizes Distinct Kringle Domains on Apolipoprotein(a)* (1996) (31)
- TAM receptors in cardiovascular disease (2019) (29)
- Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis (2021) (28)
- Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity (2015) (28)
- A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice (2019) (28)
- Pivotal role of calcium/calmodulin-dependent protein kinase II in ER stress-induced apoptosis (2010) (27)
- The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction. (1989) (26)
- Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. (1998) (26)
- Recognition of vesicular lipoproteins by the apolipoprotein B,E receptor of cultured fibroblasts. (1986) (26)
- Accelerating the pace of atherosclerosis research. (2015) (26)
- A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression (2011) (25)
- Phospholipid metabolism in cholesterol-loaded macrophages (1997) (24)
- Suppression of Macrophage Eicosanoid Synthesis by Atherogenic Lipoproteins Is Profoundly Affected by Cholesterol-Fatty Acyl Esterification and the Niemann-Pick C Pathway of Lipid Trafficking* (2004) (24)
- Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. (2021) (24)
- Macrophage foam cell lipoprotein(a)/apoprotein(a) receptor. Cell-surface localization, dependence of induction on new protein synthesis, and ligand specificity. (1994) (22)
- Role of cholesterol and lipid organization in (2005) (22)
- Macrophages Use Apoptotic Cell-Derived Methionine and DNMT3A During Efferocytosis to Promote Tissue Resolution (2022) (21)
- An Apolipoprotein(a) Peptide Delays Chylomicron Remnant Clearance and Increases Plasma Remnant Lipoproteins and Atherosclerosis In Vivo (2005) (20)
- Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages. (1997) (20)
- [37] Lipoprotein-liposome interactions (1986) (19)
- Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity. (1990) (19)
- Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis. (2021) (19)
- Sphingolipids and atherosclerosis: a mechanistic connection? A therapeutic opportunity? (2004) (19)
- Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages (2022) (19)
- Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity (2020) (17)
- TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis. (2021) (17)
- Homozygosity for an Allele Encoding Deacetylated FoxO1 Protects Macrophages From Cholesterol-Induced Inflammation Without Increasing Apoptosis (2011) (17)
- Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1-314) transgenic mice. (1999) (17)
- Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein. (2005) (17)
- N-asparagine-linked oligosaccharides: processing. (1982) (17)
- Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis (2022) (17)
- Cholesterol esterification as a limiting factor in accumulation of cell cholesterol: a comparison of two J774 macrophage cell lines. (1989) (16)
- Heart disease: Death-defying plaque cells (2016) (16)
- In search of a starting point. (2001) (15)
- Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells. (1995) (15)
- PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment (2020) (15)
- Common Therapeutic Targets in Cardiometabolic Disease (2014) (14)
- A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase (2005) (13)
- Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity (2015) (13)
- Interferon-gamma down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-gamma. (1994) (13)
- A Two-Carbon Switch to Sterol-Induced Autophagic Death (2007) (12)
- An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. (2019) (12)
- The inflammatory cytokine response of cholesterol‐enriched macrophages is dampened by stimulated pinocytosis (2007) (11)
- The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis. (2007) (10)
- How an artery heals. (2015) (10)
- Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression (2016) (10)
- Lipids and Atherosclerosis. (1960) (10)
- Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool (2018) (9)
- ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution. (2021) (9)
- p 53 and Atherosclerosis (2001) (8)
- Cardiology: Bad matters made worse (2012) (7)
- Macrophages Deficient in CTP:Phosphocholine Cytidylyltransferase-α Are Viable under Normal Culture Conditions but Are Highly Susceptible to Free Cholesterol-induced Death (2000) (6)
- The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver (2022) (6)
- Lipoprotein-liposome interactions. (1986) (6)
- Boosting Inflammation Resolution in Atherosclerosis (2017) (5)
- Chapter 22 Lipids and atherosclerosis (2002) (4)
- Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues. (1991) (4)
- Endocytosed/ -VLDL and LDL Are Delivered to Different Intracellular Vesicles in Mouse Peritoneal Macrophages (2002) (4)
- In search of an endpoint. (2000) (4)
- A new RIDDle in DC-mediated cross-presentation (2014) (3)
- Differential effects of pioglitazone on advanced atherosclerotic lesions. (2009) (3)
- Atherosclerosis: cell biology and lipoproteins Editorial comment (1994) (3)
- CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis (2022) (3)
- CaMKII in Cardiometabolic Disease (2014) (3)
- Atherosclerosis: cell biology and lipoproteins. (1997) (3)
- Mechanisms and Consequences of Cholesterol Loading in Macrophages (1998) (3)
- B-Very Low Density Lipoprotein Is Sequestered in Surface-connected Tubules in Mouse Peritoneal Macrophages (2002) (2)
- A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes (2018) (2)
- PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages (2023) (2)
- chapter 23 – Cellular Cholesterol Metabolism in Health and Disease (2004) (1)
- The Markedly Increased PAI1 in Obesity Induces a Compensatory Increase of Hepatocyte Tpa Expression By Activating a LRP1-CREB1 Pathway (2019) (1)
- Ira Tabas The Importance of Lesion Stage and Phagocytic Efficiency Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis (2005) (1)
- Abstract 637: Genome-wide Crispr Screen in Primary Macrophages for Identification of a Regulatory Network for Macrophage Efferocytosis (2018) (1)
- A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis (2022) (1)
- The J774 Macrophage Model of Native LDL-Induced Foam Cell Formation (1987) (1)
- Making things stick in the fight against atherosclerosis. (2013) (1)
- Macrophages Govern the Progression and Termination of Inflammation in Atherosclerosis and Metabolic Diseases (2014) (1)
- Macrophages, apoptotic cells and cholesterol -- strategies for survival: an interview with Dr. Ira Tabas. Interview by Helene F. Rosenberg. (2007) (1)
- STEPS IN THE FORMATION OF ASPARAGINE-LINKED CARBOHYDRATE MOIETIES (1981) (1)
- Signal transduction pathways in free cholesterol-loaded macrophages: cell biological insight into the progression of atherosclerosis (2004) (1)
- Abstract 29: MiR-33 Coordinately Regulates Macrophage Autophagy (2014) (0)
- Abstract 20707: Macrophage Mitochondrial Fission is Essential for Continued Clearance of Apoptotic Cells and Plays a Protective Role in Advanced Atherosclerosis (2014) (0)
- Dendritic cells in atherosclerosis (2013) (0)
- Abstract 146: Tipping the Balance of Hepatocyte-Derived tPA and PAI1 Contributes to Defective Fibrinolysis in Obesity (2019) (0)
- Protein Response Homeostasis and Activates the Unfolded Deficiency Disrupts Organelle ARV 1 Loss of Subcellular Lipid Transport Due to Lipids : (2011) (0)
- Abstract: 619 MECHANISMS AND CONSEQUENCES OF MACROPHAGE DEATH IN ATHEROSCLEROSIS (2009) (0)
- A therapeutically targetable TAZ-TEAD2 pathway drives the growth of hepatocellular carcinoma via ANLN and KIF23. (2023) (0)
- Hepatocyte-Derived Tissue Plasminogen Activator Regulates Systemic Fibrinolysis (2018) (0)
- Abstract 240: Ornithine Decarboxylase Drives Efferocytosis-induced Il-10 Production and Inflammation Resolution (2020) (0)
- Linking obesity to plaque progression – can the multifunctional adipokine Nampt promote detrimental persistence of macrophages in atherosclerotic lesions? (2010) (0)
- ATVB in Focus Cell Death in Cardiovascular Disease (2011) (0)
- Glass Opportunities Anti-Inflammatory Therapy in Chronic Disease : Challenges and (2013) (0)
- Abstract 11646: ATVB Outstanding Research Award : WDFY3 is Required for the Efficient Degradation of Engulfed Apoptotic Cells by Macrophages During Efferocytosis (2021) (0)
- Abstract 14660: A Nanomedicine-Based Treatment Regimen to Induce Plaque Remodeling to a Favorable Phenotype in Mice With Advanced Atherosclerosis (2013) (0)
- Retinal atrophy phenotypes associated with light sensitivity and inflammation in the new MerTK-cleavage resistant mouse model (2020) (0)
- Abstract B04: Hepatic cholesterol upregulates TAZ in nonalcoholic steatohepatitis (2020) (0)
- A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis (2022) (0)
- Circulating indian hedgehog is a marker of the hepatocyte-TAZ pathway in experimental NASH and is elevated in humans with NASH. (2023) (0)
- Efferocytosis-Induced Lactate Enables the Proliferation of Pro-Resolving Macrophages to Mediate Tissue Repair (2023) (0)
- Efferocytosis in health and disease (2019) (0)
- Abstract 040: Accelerated Atherosclerosis and Thrombosis in Jak2v617f Mice (2018) (0)
- Efferocytosis induces a transient burst of glycolysis in macrophages to promote lactate-driven binding and continuing removal of apoptotic cells (2022) (0)
- Sitosterol-containingLipoproteinsTriggerFreeSterol-induced Caspase-independentDeathinACAT-competentMacrophages * (2006) (0)
- Molecular Mechanisms and Treatment Strategies for Obesity-Associated Coronary Artery Disease, an Imminent Military Epidemic (2006) (0)
- NPC - LINKS TO DYSLIPIDEMIA BUT NOT CARDIOVASCULAR RISK: 55 (2005) (0)
- Targeting soluble DPP-4 for insulin resistance: Origin matters. (2020) (0)
- Opportunity? Sphingolipids and Atherosclerosis : A Mechanistic Connection? A Therapeutic (2012) (0)
- Atherosclerosis: cell biology and lipoproteins. (1994) (0)
- Abrogating Foam Cell Formation in Hyperlipidemic Mice Loss of SRA and CD 36 Activity Reduces Atherosclerotic Lesion Complexity (2008) (0)
- FoxOs promote apoptosis of insulin resistant macrophages during cholesterol-induced ER stress (2008) (0)
- Depression in Reduced Preparations Long-Term Mobilization Is Not Required for Cerebellar Inositol-1,4,5-Trisphosphate Receptor-Mediated Ca (2015) (0)
- 2WS11-1 Signal transduction pathways in free cholesterol-loaded macrophages: Cell biological insight into the progression of atherosclerosis (2003) (0)
- The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis Ira Tabas (2010) (0)
- Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance. (2022) (0)
- Pharmacological Induction of Adiponectin by PPAR Agonism Does Not Prevent Atherosclerosis in Lean Mice (2010) (0)
- Hepatocyte DACH 1 Is Incr eased in Obesity via Nuclear Exclusion of HDAC 4 and Promotes Hepatic Insulin Resistance Graphical (2016) (0)
- Secretory sphingomyelinase and atherosclerosis (2000) (0)
- Abstract IA23: The role of hepatocyte TAZ in NASH and NASH-HCC (2020) (0)
- 2.W18.4 Arterial-wall sphingomyelinase and atherogenesis (1997) (0)
- Hepatocyte TAZ / WWTR 1 P romotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis Graphical (0)
- A Potential Role for Regulatory T Cells in Apoptotic Cell Clearance by Macrophages in a Murine Model of Acute Lung Injury (2015) (0)
- Final discussion: Nutrition, ageing and lipotoxicity (2007) (0)
- The UPR in atherosclerosis (2013) (0)
- Ira Tabas , Kevin Jon Williams and Jan Borén and Therapeutic Implications Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis : Update (2007) (0)
- Abstract 405: Deficiency of p38{alpha} MAPK in Macrophages Promotes Apoptosis and Plaque Necrosis in Advanced Murine Atherosclerotic Lesions (2008) (0)
- A Hepatocyte Transcription Repressor DACH1 Inhibits Fibrinolysis and Increases Risk of Thrombosis (2017) (0)
- Interference with ER stress and restoration of efferocytosis in the treatment of advanced atherosclerosis (2012) (0)
- IEW Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress (2011) (0)
- List of contributors**Authors’ names are followed by the starting page number(s) of their contribution(s). (2008) (0)
- P88-S Macromolecular Interactions: PPARy Ligands Enhance Phagocytic Clearance of Apoptotic Macrophages (2007) (0)
- The Influence of Particle Size and Multiple Apoprotein E-Receptor Interactions on the Endocytic Targeting of O3VLDL in Mouse Peritoneal Macrophages (2002) (0)
- Expansion of Regulatory T Cells Promotes the Clearance of Apoptotic Cells by Macrophages in Murine Atherosclerotic Plaques (2016) (0)
- Studies of the synthesis, structure and function of the phosphorylated oligosaccharides of lysosomal enzymes (1983) (0)
- The New York Lipid and Vascular Biology Research Club (2014) (0)
- Novel concept of plaque progression: TLR4 activation propagates inflammatory response in macrophages (2011) (0)
- Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis (2021) (0)
- Issue Information (2008) (0)
- The Role of Arv1 in Sterol Metabolism and its Contribution to the Unfolded Protein Response (2010) (0)
- Abstract 18944: The Mir-33 Locus Coordinately Regulates Macrophage Autophagy (2016) (0)
- Results Suppression of Myeloid Cell mitoOS Protects Against Atherosclerosis and Reduces Myeloid Cell Accumulation in Aged Mice (2017) (0)
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