Irwin Rose
#2,860
Most Influential Person Now
American biologist
Irwin Rose's AcademicInfluence.com Rankings
Irwin Rosebiology Degrees
Biology
#282
World Rank
#513
Historical Rank
#164
USA Rank
Biochemistry
#48
World Rank
#63
Historical Rank
#32
USA Rank
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Biology
Irwin Rose's Degrees
- PhD Biochemistry University of Chicago
- Bachelors Chemistry University of Chicago
Why Is Irwin Rose Influential?
(Suggest an Edit or Addition)According to Wikipedia, Irwin Allan Rose was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.
Irwin Rose's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Glutathione (1960) (1464)
- Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. (1980) (651)
- Enzyme structure and mechanism (2nd edn): by Alan Fersht, W. H. Freeman & Co., 1985. £14.95 pbk, £28.95 hbk (xxi + 475 pages) ISBN 0 7167 1615 1 (1985) (513)
- Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. (1982) (377)
- Mitochondrial hexokinase. Release, rebinding, and location. (1967) (329)
- The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. (1982) (310)
- Enzymatic phosphorylation of acetate. (1954) (300)
- Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. (1979) (192)
- Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. (1984) (191)
- Functional heterogeneity of ubiquitin carrier proteins. (1985) (183)
- Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. (1987) (181)
- The mechanism of the triosephosphate isomerase reaction. (1959) (167)
- Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides. (1985) (166)
- Role of inorganic phosphate in stimulating the glucose utilization of human red blood cells. (1964) (155)
- A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation. (1992) (150)
- Mechanism of aconitase action. I. The hydrogen transfer reaction. (1967) (145)
- THE ROLE OF GLUCOSE 6-PHOSPHATE IN THE REGULATION OF GLUCOSE METABOLISM IN HUMAN ERYTHROCYTES. (1964) (139)
- Intramolecular hydrogen transfer in the phosphoglucose isomerase reaction. (1961) (132)
- The state of magnesium in cells as estimated from the adenylate kinase equilibrium. (1968) (131)
- Control of glycolysis in the human red blood cell. (1966) (126)
- A stereochemical method for detection of ATP terminal phosphate transfer in enzymatic reactions. Glutamine synthetase. (1976) (121)
- [97] Acetate kinase of bacteria (acetokinase): Acetate + ATP ⇄ Acetyl-P + ADP☆ (1955) (120)
- Interpretations of enzyme reaction stereospecificity (1975) (119)
- Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. (1981) (113)
- Determination of the rate of hexokinase-glucose dissociation by the isotope-trapping method. (1974) (109)
- Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: role of hemin in regulating ubiquitin conjugate degradation. (1981) (106)
- Ubiquitin adenylate: structure and role in ubiquitin activation. (1983) (97)
- MECHANISM OF THE ALDOLASE REACTION. (1965) (93)
- Incorporation of C14 totally labeled nucleosides into nucleic acids. (1953) (91)
- The isotope trapping method: desorption rates of productive E.S complexes. (1980) (89)
- Activators of yeast hexokinase. (1971) (86)
- Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin. (1986) (83)
- Mechanisms of Enzyme Action (1966) (80)
- The Absolute Configuration of Dihydroxyacetone Phosphate Tritiated by Aldolase Reaction1 (1958) (80)
- Studies on the enolization of pyruvate by pyruvate kinase. (1960) (77)
- Studies on the mechanism on the aldolase reaction; isotope exchange reactions of muscle and yeast aldolase. (1958) (75)
- Mechanism of the aldose-ketose isomerase reactions. (1975) (73)
- A suggestion for naming faces of ring compounds. (1980) (71)
- Stereochemistry of pyruvate kinase, pyruvate carboxylase, and malate enzyme reactions. (1970) (69)
- Studies on the interaction of aldolase with substrate analogues. (1969) (67)
- Ascites tumor mitochondrial hexokinase II. Effect of binding on kinetic properties. (1968) (66)
- THE ABSOLUTE STEREOCHEMICAL COURSE OF CITRIC ACID BIOSYNTHESIS. (1963) (66)
- An enzyme with ubiquitin carboxy-terminal esterase activity from reticulocytes. (1983) (64)
- Anomeric specificity and mechanism of two pentose isomerases. (1971) (64)
- Catalytic reactions of phosphoglucose isomerase with cyclic forms of glucose 6-phosphate and fructose 6-phosphate. (1973) (62)
- Fructose 1,6-bisphosphate: isomeric composition, kinetics, and substrate specificity for the aldolases. (1976) (60)
- Specificity for the glucose-6-P inhibition site of hexokinase. (1974) (57)
- The proton transfer reactions of muscle pyruvate kinase. (1972) (56)
- Evidence that carboxyphosphate is a kinetically competent intermediate in the carbamyl phosphate synthetase reaction. (1979) (56)
- Regulation of mammalian hexokinase: regulatory differences between isoenzyme I and II. (1973) (55)
- THE MECHANISM OF ACTION OF MUSCLE ALDOLASE1 (1955) (54)
- Some properties of oxalacetic carboxylase. (1954) (54)
- Glucose- and mannose-1,6-P2 as activators of phosphofructokinase in red blood cells. (1974) (53)
- THE STEREOCHEMISTRY OF DECARBOXYLATION OF ISOCITRATE BY ISOCITRIC ACID DEHYDROGENASE. (1964) (52)
- Stereospecificity of the sugarphosphate isomerase reactions; a uniformity. (1960) (51)
- Inactivation and labeling of triose phosphate isomerase and enolase by glycidol phosphate. (1969) (50)
- Control of red cell glycolysis. The cause of triose phosphate accumulation. (1970) (49)
- Nuclear magnetic resonance assignment of the vinyl hydrogens of phosphoenolpyruvate. Stereochemistry of the enolase reaction. (1970) (49)
- THE DISTRIBUTION OF C$sup 14$ IN GLYCOGEN FROM DEUTERATED GLYCEROL-C$sup 14$ AS A MEASURE OF THE EFFECTIVENESS OF TRIOSEPHOSPHATE ISOMERASE IN VIVO (1962) (48)
- THE MECHANISM OF ACTION OF 6-PHOSPHOGLUCONATE DEHYDROGENASE. (1964) (48)
- Stereochemical evidence for a cis-enediol intermediate in Mn-dependent aldose isomerases. (1969) (46)
- A high molecular weight protease in liver cytosol. (1979) (44)
- Studies on the mechanism of Escherichia coli glucosamine-6-phosphate isomerase. (1977) (44)
- Identification of Site in Triose Phosphate Isomerase Labelled by Glycidol Phosphate (1970) (42)
- Isotope trapping studies of yeast hexokinase during steady state catalysis. A combined rapid quench and isotope trapping technique. (1979) (40)
- Concentration of activated intermediates of the fructose-1,6-bisphosphate aldolase and triosephosphate isomerase reactions. (1981) (39)
- Product inhibition of the hexokinases. (1970) (39)
- Stereochemistry of the enzymatic carboxylation of phosphoenolpyruvate. (1969) (38)
- Proton diffusion in the active site of triosephosphate isomerase. (1990) (38)
- A specific enzyme for glucose 1,6-bisphosphate synthesis. (1975) (38)
- Affinity labeling of phosphoglucose isomerase by 1,2-anhydrohexitol-6-phosphates. (1973) (36)
- Phosphorylation by particulate preparations of Azotobacter vinelandii. (1956) (35)
- DETERMINATION BY NEUTRON AND X-RAY DIFFRACTION OF THE ABSOLUTE CONFIGURATION OF AN ENZYMATICALLY FORMED ALPHA-MONO DEUTERIOGLYCOLATE. (1965) (35)
- Mannose 6-phosphate: anomeric form used by phosphomannose isomerase and its 1-epimerization by phosphoglucose isomerase. (1973) (35)
- Functional heterogeneity of ubiquitin carrier proteins. (1985) (34)
- Chemistry of proton abstraction by glycolytic enzymes (aldolase, isomerases and pyruvate kinase). (1981) (34)
- The use of kinetic isotope effects in the study of metabolic control. I. Degradation of glucose-1-D by the hexosemonophosphate pathway. (1961) (34)
- Inactivation of muscle triose phosphate isomerase by D- and L-glycidol phosphate. (1973) (33)
- Mechanism of the action of glyoxalase I. (1957) (33)
- Mechanisms of enzyme-catalyzed group transfer reactions. (1978) (33)
- THE POSITION OF CARBON-CARBON BOND CLEAVAGE IN THE RIBULOSE DIPHOSPHATE CARBOXYDISMUTASE REACTION. (1965) (32)
- Glycolysis: Regulation and Mechanisms of the Enzymes (1969) (32)
- Outlines of Enzyme Chemistry (1955) (32)
- Studies on the mechanism and stereochemical properties of the oxalacetate decarboxylase activity of pyruvate kinase. (1976) (32)
- PHYSICAL, CHEMICAL, AND ENZYMOLOGICAL CHARACTERIZATION OF ENOLPYRUVATE (1979) (30)
- Mechanism for oxygen exchange in the chloroplast photophosphorylation system. (1977) (29)
- Enzyme reaction stereospecificity: a critical review. (1972) (29)
- Oxalacetate decarboxylase activity in muscle is due to pyruvate kinase. (1976) (29)
- The role of the allosteric B site in the fumarase reaction. (2004) (28)
- Mechanism of ribulose-diphosphate carboxydismutase reaction. (1967) (28)
- Lithium action on glucose uptake in brain; Role of glucose-1,6-P2 as a regulator of hexokinase (1980) (28)
- Intermediates in the ribulose-1,5-bisphosphate carboxylase reaction. (1984) (28)
- Enolpyruvate: chemical determination as a pyruvate kinase intermediate. (1991) (28)
- Stability of hexokinase II in vitro and in ascites tumor cells. (1982) (27)
- 5 Enzymology of Proton Abstraction and Transfer Reactions (1970) (27)
- COUPLING OF REDUCED PYRIDINE NUCLEOTIDE IN LEUCONOSTOC MESENTEROIDES. (1964) (26)
- Purification and kinetic properties of aconitate isomerase from Pseudomonas putida. (1971) (25)
- Stereochemistry of the interconversions of citrate and acetate catalyzed by citrate synthase, adenosine triphosphate citrate lyase, and citrate lyase. (1971) (25)
- Ubiquitin at Fox Chase* (2005) (24)
- How fumarase recycles after the malate --> fumarate reaction. Insights into the reaction mechanism. (1998) (24)
- Kinetic competence of a phosphoryl enzyme intermediate in the glucose-1,6-p2 synthase-catalyzed reaction. Purification, properties, and kinetic studies. (1976) (23)
- Origin of the delayed feedback control of glucose utilization in ascites tumor cells. (1972) (23)
- Effect of Vitamin B12 on Nucleic Acid Metabolism of the Rat∗ (1952) (22)
- Proton transfer in catalysis by fumarase. (1992) (21)
- Chemical trapping of complexes of dihydroxyacetone phosphate with muscle fructose-1,6-bisphosphate aldolase. (1985) (20)
- Mechanism of the aconitate isomerase reaction. (1971) (20)
- The substrate proton of the pyruvate kinase reaction. (1989) (20)
- Use of Borate in the Paper Chromatography of Ribosides1 (1951) (20)
- Ubiquitin Carboxyl-Terminal Hydrolases (1988) (20)
- pH dependence of the α-glucose 1,6-diphosphate inhibition of hexokinase II☆ (1975) (19)
- Concentration and partitioning of intermediates in the fructose bisphosphate aldolase reaction. Comparison of the muscle and liver enzymes. (1987) (19)
- Positional isotope exchange studies of enzyme mechanisms. (1979) (18)
- Intermolecular tritium transfer in the transcarboxylase reaction. (1976) (18)
- Stereochemistry of ketonization of enolpyruvate by pyruvate kinase. Evidence for its role as an intermediate (1978) (18)
- Aconitase: its source of catalytic protons. (1987) (17)
- Restructuring the active site of fumarase for the fumarate to malate reaction. (1997) (17)
- Production of pyruvate and succinate by action of isocitrate lyase on -methylisocitrate. (1972) (17)
- Proton transfer reactions of methylglyoxal synthase. (1977) (17)
- Inhibitors of glucose-1,6-bisphosphate synthase. (1977) (17)
- Pentose Metabolism in Bacteria (1963) (16)
- A specific endpoint assay for ubiquitin. (1987) (16)
- A rate-determining proton relay in the pyruvate kinase reaction. (1991) (16)
- Role of conformational change in the fumarase reaction cycle. (1993) (16)
- Ubiquitin at Fox Chase (Nobel lecture). (2005) (15)
- Utilization of enolpyruvate by the carboxybiotin form of transcarboxylase: evidence for a nonconcerted mechanism (1982) (15)
- THE MECHANISM OF ACTION OF ALDOLASE AND THE ASYMMETRIC LABELING OF HEXOSE. (1958) (15)
- Complexes of muscle aldolase in equilibrium with fructose 1,6-bisphosphate. (1985) (14)
- Secondary isotope effects in reactions catalyzed by yeast and muscle aldolase. (1969) (14)
- Methylglyoxal synthetase, enol-pyruvaldehyde, glutathione and the glyoxalase system. (2002) (13)
- Specificity of fructose-1, 6-P2 aldolase (muscle) and partition of the enzyme among catalytic intermediates in the steady state. (1977) (13)
- Glucose exchange and catalysis by two crystalline hexokinase x glucose complexes. Evidence for an obligatory ATP-dependent conformational change in catalysis. (1980) (12)
- Glycidol phosphates and 1,2-anhydrohexitol 6-phosphates. (1977) (12)
- Liberation of the triosephosphate isomerase reaction intermediate and its trapping by isomerase, yeast aldolase, and methylglyoxal synthase. (1981) (12)
- Formation of enolpyruvate in the phosphoenolpyruvate carboxytransphosphorylase reaction. (1973) (11)
- Distribution of the Glucose‐1,6‐Bisphosphate System in Brain and Retina (1988) (11)
- Activation of yeast hexokinase PII. Changes in conformation and association. (1979) (10)
- Inactivation and reactivation of hexokinase type II. (1974) (10)
- Partition kinetics of ribulose-1,5-bisphosphate carboxylase from Rhodospirillum rubrum. (1985) (10)
- Demonstration of the Schiff base mechanism in an aldolase reaction by oxygen exchange. (1967) (8)
- Glycolysis-dependent exchange of diphosphopyridine nucleotide-3H in red blood cells and ascites cells. (1969) (8)
- Mechanism of Chlorophyll Action in Photosynthesis (1958) (7)
- Study of crystalline hexokinase-glucose complexes by isotope trapping. (1981) (7)
- Significance of ADP-ATP exchange for the hexokinase reaction mechanism. (1971) (7)
- Mechanism of Aconitase Action (2001) (7)
- Mechanism of C-H bond cleavage in aldolase and isomerase reactions. (1962) (7)
- Early work on the ubiquitin proteasome system, an interview with Irwin Rose (2005) (7)
- Mechanism of phosphoryl transfer by hexokinase. (1980) (6)
- [8] Enzymology of enol intermediates (1982) (6)
- Ubiquitin at Fox Chase. (2005) (6)
- Methylglyoxal synthase uses the trans isomer of triose-1,2-enediol 3-phosphate (1983) (6)
- Role of CO2 in proton activation by histidine decarboxylase (pyruvoyl). (1992) (5)
- Failure to confirm previous observations on triosephosphate isomerase intermediate and bound substrate complexes. (1984) (5)
- PURINE AND PYRIMIDINE REQUIREMENTS OF LACTOBACILLUS LEICHMANNII IN THE PRESENCE OF VITAMIN B12 OR THYMIDINE (1952) (4)
- Partition analysis: detecting enzyme reaction cycle intermediates. (1995) (4)
- Isotopic strategies for the study of enzymes (1995) (4)
- Mechanism of proton abstraction in biotin-dependent carboxylation reactions (1993) (4)
- Pyrimidine precursors for Lactobacillus bulgaricus 09. (1954) (4)
- Preparation of phosphoenolpyruvate and pyruvate specifically labeled with deuterium and tritium. (1975) (3)
- Lack of exchange of the 1-oxygen of glucose with water during glucose transport in human red blood cells. (1968) (3)
- Water-d2 effect on catalysis by triose phosphate isomerase requires isotope exchange on the enzyme (1983) (3)
- Lithium on glucose uptake in brain; role of glucose-1,6-P2 as a regulator of hexokinase. (1980) (3)
- Partition of intermediates of triosephosphate isomerase: slow conformational changes precede enolization and follow product release. (1982) (2)
- Ubiquitin in Fox Chase (Nobel‐Vortrag) (2005) (2)
- Uso de plantas medicinais para o tratamento de feridas Use by medicinal plants for wound care Uso de las plantas medicinales para el cuidado de heridas (2015) (1)
- Enzyme reactions of ATP studied by positional isotope exchange. (1978) (1)
- THE CONTROL OF HEXOKINASE IN ASCITES TUMOR GLYCOLYSIS (1965) (1)
- Mechanistic Inferences from Stereochemistry (2006) (1)
- Molecular Asymmetry in Biology. Ronald Bentley. Academic Press, New York, 1969-70. 2 vols. Vol. 1, xii, 324 pp., illus., $14; vol. 2, xvi, 568 pp., illus., $27.50. Molecular Biology Series (1970) (0)
- Enzymology of enol intermediates. (1982) (0)
- METHOD OF TREATING HYPERLIPIDEMIA AND INCREASING WIGOR WITH SAID PRODUCT (2017) (0)
- PURINE AND PYRIMIDINE REQUIREMENTS OF LACTOBACILLUS LEICHMANNII IN THE PRESENCE OF VITAMIN Bu OR THYMIDINE ' (0)
- Cecile M. Pickart (1954-2006). (2006) (0)
- Biological Stereochemistry: Molecular Asymmetry in Biology . Ronald Bentley. Academic Press, New York, 1969-70. 2 vols. Vol. 1, xii, 324 pp., illus., $14; vol. 2, xvi, 568 pp., illus., $27.50. Molecular Biology Series. (1970) (0)
- PH dependence of the alpha-glucose 1,6-diphosphate inhibition of hexokinase II. (1975) (0)
- Book Review:Transition States of Biochemical Processes. Richard D. Gandour, Richard L. Schowen (1980) (0)
- The role of alpha--beta glucose-6-phosphate interconversion in erythrocyte carbohydrate metabolism. (1967) (0)
- Polysaccharides in Biology (1957) (0)
- Biological Stereochemistry. (Book Reviews: Molecular Asymmetry in Biology) (1970) (0)
- Hemm inhibits ATP-dependent ubiquitin-dependent proteolysis : Role of hemin in regulating ubiquitin conjugate degradation ( protein degradation / energy requirement / isopeptide linkage ) (0)
- Failure to confirm our observations of reactivity of triose-P isomerase, methylglyoxal synthase, and ferricyanide with triose-P enediol (1984) (0)
- Activation of Yeast Hexokinase PI 1 CHANGES (2002) (0)
- BIOCHEMISTRY: I. A. ROSE serum exercises a strong stimulating action on the growth of single mammalian cells (0)
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