Israel H. Silman
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Israel H. Silmanchemistry Degrees
Chemistry
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Organic Chemistry
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Israel H. Silmanphysics Degrees
Physics
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Biophysics
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Chemistry Physics
Israel H. Silman's Degrees
- PhD Biophysics Weizmann Institute of Science
Why Is Israel H. Silman Influential?
(Suggest an Edit or Addition)Israel H. Silman's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein (1991) (2364)
- The a/ hydrolase fold (1992) (1829)
- Function and structure of inherently disordered proteins. (2008) (900)
- FoldIndex copyright: a simple tool to predict whether a given protein sequence is intrinsically unfolded (2005) (791)
- Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. (1994) (715)
- FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded. (2005) (695)
- Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. (1999) (595)
- Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes (2004) (589)
- Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins (1993) (546)
- Acetylcholinesterase: from 3D structure to function. (2010) (537)
- The alpha/beta hydrolase fold. (1992) (514)
- Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. (2005) (454)
- Water-insoluble derivatives of enzymes, antigens, and antibodies. (1966) (428)
- Specific chemical and structural damage to proteins produced by synchrotron radiation. (2000) (390)
- Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. (2007) (378)
- A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. (2001) (360)
- Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A (1997) (338)
- Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. (2000) (301)
- The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase. (1996) (298)
- Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. (2004) (279)
- Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors (2000) (275)
- Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. (2002) (269)
- Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis. (1992) (262)
- Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution (1999) (262)
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (2016) (256)
- X‐ray structure of human acid‐β‐glucosidase, the defective enzyme in Gaucher disease (2003) (249)
- Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. (1999) (242)
- An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase. (1993) (234)
- A beta-D-galactoside binding protein from electric organ tissue of Electrophorus electricus. (1975) (234)
- Open "back door" in a molecular dynamics simulation of acetylcholinesterase. (1994) (230)
- Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins (1986) (224)
- Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target. (1995) (223)
- Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. (2012) (195)
- Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. (2011) (179)
- Acetylcholinesterase: how is structure related to function? (2008) (176)
- Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. (2006) (173)
- Modes of attachment of acetylcholinesterase to the surface membrane. (1987) (163)
- Structural insights into substrate traffic and inhibition in acetylcholinesterase (2006) (151)
- Structure and dynamics of the active site gorge of acetylcholinesterase: Synergistic use of molecular dynamics simulation and X‐ray crystallography (1994) (144)
- Proteomic signatures: Amino acid and oligopeptide compositions differentiate among phyla (2003) (143)
- Structure and functions of acetylcholinesterase and butyrylcholinesterase. (1993) (139)
- Papain-collodion membranes. I. Preparation and properties. (1968) (139)
- Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. (2012) (139)
- Reaction Products of Acetylcholinesterase and VX Reveal a Mobile Histidine in the Catalytic Triad (1999) (129)
- An idea whose time has come (2007) (129)
- Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain (1979) (125)
- Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase. (1985) (123)
- Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica. (2000) (122)
- Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages (2009) (118)
- Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. (2008) (117)
- Immunochemical studies on acetylcholine receptor from Torpedo californica. (1977) (117)
- Structural disorder serves as a weak signal for intracellular protein degradation (2008) (117)
- 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates. (2002) (117)
- Microtiter assay for acetylcholinesterase. (1987) (112)
- A server and database for dipole moments of proteins (2007) (111)
- Acetylcholine Receptor: Covalent Attachment of Depolarizing Groups at the Active Site (1969) (110)
- Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C. (1985) (109)
- Effect of the microenvironment on the mode of action of immobilized enzymes. (2006) (108)
- Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease. (2007) (104)
- Experimental autoimmune myasthenia induced in monkeys by purified acetylcholine receptor (1975) (104)
- The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix (2004) (104)
- Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics. (2008) (103)
- Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules (2008) (102)
- Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome (2007) (102)
- New directions in the treatment of Gaucher disease. (2004) (102)
- Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica (1998) (100)
- The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. (2004) (99)
- Solubilization of Membrane‐Bound Acetyicholinesterase by a Phosphatidylinositol‐Specific Phospholipase C (1985) (98)
- Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs. (1993) (97)
- X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. (2002) (97)
- Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs. (1998) (95)
- Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease. (2003) (93)
- X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. (2005) (93)
- Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C. (1988) (92)
- A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C (1983) (90)
- Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification. (2012) (89)
- Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime. (2009) (83)
- How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations. (2003) (82)
- Intrinsic forms of acetylcholinesterase in skeletal muscle (1978) (80)
- Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. (2003) (80)
- Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle (1979) (79)
- DEVELOPMENTAL CHANGES IN LEVELS AND FORMS OF CHOLINESTERASES IN MUSCLES OF NORMAL AND DYSTROPHIC CHICKENS (1979) (77)
- Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations. (2012) (77)
- External and internal electrostatic potentials of cholinesterase models. (1997) (73)
- Appearance and disappearance of acetycholine receptor during differentiation of chick skeletal muscle in vitro (1976) (70)
- A server and database for dipole moments of proteins (2007) (70)
- Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase. (1994) (70)
- Context‐dependent resistance to proteolysis of intrinsically disordered proteins (2011) (69)
- Specific protein dynamics near the solvent glass transition assayed by radiation‐induced structural changes (2001) (67)
- Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation. (2002) (59)
- Oxidative stress transforms acetylcholinesterase to a molten-globule-like state. (1994) (57)
- Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. (2013) (57)
- The intracellular domain of the Drosophila cholinesterase‐like neural adhesion protein, gliotactin, is natively unfolded (2003) (57)
- Characterization of activities and forms of cholinesterases in human primary brain tumors (1984) (56)
- A structure-based design approach to the development of novel, reversible AChE inhibitors. (2001) (55)
- Site‐directed mutants designed to test back‐door hypotheses of acetylcholinesterase function (1996) (54)
- How Does Ammonium Interact with Aromatic Groups? A Density Functional Theory (DFT/B3LYP) Investigation (2000) (53)
- Backdoor opening mechanism in acetylcholinesterase based on X‐ray crystallography and molecular dynamics simulations (2011) (53)
- Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography (2008) (53)
- Induced‐fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure‐based drug design (2008) (52)
- RECOMMENDATIONS FOR NOMENCLATURE IN CHOLINESTERASES (1992) (52)
- Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors. (2007) (50)
- Quantum/Classical Mechanical Comparison of Cation−π Interactions between Tetramethylammonium and Benzene (2001) (49)
- Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures. (2001) (49)
- Chemical modification of Torpedo acetylcholinesterase by disulfides: appearance of a "molten globule" state. (1992) (48)
- Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation. (2005) (48)
- Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Evidence for a common membrane-anchoring structure. (1987) (47)
- Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. (2008) (47)
- Acetylcholinesterase in Schistosoma mansoni is anchored to the membrane via covalently attached phosphatidylinositol. (1988) (47)
- Irreversible thermal denaturation of Torpedo californica acetylcholinesterase (1995) (46)
- Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration. (2018) (46)
- The induction by protons of ion channels through lipid bilayer membranes. (1983) (46)
- Some water‐insoluble papain derivatives (1966) (46)
- Acid β-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy (2008) (45)
- Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. (2009) (45)
- A modular treatment of molecular traffic through the active site of cholinesterase. (1999) (44)
- Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase. (2002) (44)
- Acetylcholinesterase: structure and use as a model for specific cation—protein interactions (1992) (43)
- Electrooptical measurements demonstrate a large permanent dipole moment associated with acetylcholinesterase. (1996) (43)
- Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase (1973) (43)
- Biosynthesis and secretion of catalytically active acetylcholinesterase in Xenopus oocytes microinjected with mRNA from rat brain and from Torpedo electric organ. (1982) (42)
- Presynaptic M2 muscarinic receptors are involved in controlling the kinetics of ACh release at the frog neuromuscular junction (2001) (41)
- Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. (2007) (41)
- 6‐Amino‐6‐deoxy‐5,6‐di‐N‐(N′‐octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β‐Glucosidase (2009) (41)
- Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase. (1999) (40)
- Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. (2006) (40)
- Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase. (2005) (40)
- Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. (2018) (37)
- Acetylcholinesterase: Structure and use as a model for specific cation-protein interactions (1992) (37)
- Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products. (1991) (37)
- Changes in the Levels and Forms of Cholinesterases in the Blood Plasma of Normal and Dystrophic Chickens (1980) (37)
- Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride. (2000) (37)
- Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents. (1994) (37)
- Noncovalent interaction or chemical bonding between alkaline earth cations and benzene? A quantum chemistry study using MP2 and density-functional theory methods (2001) (36)
- Molecular Basis of Reduced Glucosylceramidase Activity in the Most Common Gaucher Disease Mutant, N370S (2010) (35)
- 3-D Structure of Serum Paraoxonase 1 Sheds Light on Its Activity, Stability, Solubility and Crystallizability (2007) (35)
- Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer. (1997) (35)
- Preparation and immunochemical characterization of a water-soluble acetylcholine receptor fraction from the electric organ tissue of the electric eel. (1975) (35)
- Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. (2005) (35)
- A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica. (2002) (35)
- Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers. (2010) (34)
- Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse (2017) (33)
- The Crystal Structure of the Complex of the Anticancer Prodrug 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica Acetylcholinesterase Provides a Molecular Explanation for Its Cholinergic Action (2005) (33)
- Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. (2019) (33)
- Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues. (2011) (32)
- First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. (2006) (32)
- Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni. (1991) (32)
- Detection of hydroxyproline in preparations of acetylcholinesterase from the electric organ of the electric eel (1976) (32)
- Theoretical Insight into the Interactions of TMA-Benzene and TMA-Pyrrole with B3LYP Density-Functional Theory (DFT) and ab Initio Second Order Møller-Plesset Perturbation Theory (MP2) Calculations (2001) (31)
- Honing the in silico toolkit for detecting protein disorder. (2006) (31)
- Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones (2003) (30)
- A paradigm for single nucleotide polymorphism analysis: The case of the acetylcholinesterase gene (2004) (30)
- Structure of the Mitochondrial Electron Transfer Chain (1967) (30)
- Comparison of the Molecular Forms of the Cholinesterases in Tissues of Normal and Dystrophic Chickens (1982) (29)
- A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase. (1999) (29)
- Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. (2019) (29)
- Static Laue diffraction studies on acetylcholinesterase. (1998) (29)
- The subunits of an acetylcholinesterase preparation purified from trypsin‐treated electric eel tissue (1971) (27)
- Acetylcholinesterase of schistosoma mansoni—Functional correlates: Contributed in honor of Professor Hans Neurath's 90th birthday (1999) (27)
- The impact of crystallization conditions on structure‐based drug design: A case study on the methylene blue/acetylcholinesterase complex (2016) (27)
- Arrhenius plots of acetylcholinesterase activity in mammalian erythrocytes and in Torpedo electric organ. Effect of solubilization by proteinases and by a phosphatidylinositol-specific phospholipase C. (1985) (27)
- A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C (1988) (26)
- Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica. (1993) (25)
- X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide (2005) (25)
- Immunochemical and enzymic properties of the electric eel acetylcholinesterase-antiacetylcholinesterase system. (1974) (25)
- Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. (2020) (25)
- human acid-beta-glucosidase (2003) (24)
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (2018) (24)
- Molecular forms of acetylcholinesterase in synaptic and extrasynaptic regions of avian tonic muscle (1984) (24)
- Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase. (1982) (24)
- Molecular structure of acetylcholinesterase (1976) (24)
- A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials. (1994) (23)
- The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study. (2004) (23)
- Computational Studies on Acetylcholinesterases (2017) (23)
- The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad. (2009) (22)
- Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes (1996) (22)
- Inactivation of electric eel acetylcholinesterase by acylation with N-hydroxysuccinimide esters of amino acid derivatives. (1978) (22)
- Simple general acid-base catalysis of physiological acetylcholinesterase reactions (1992) (22)
- The Activity of an Endoplasmic Reticulum-localized Pool of Acetylcholinesterase Is Modulated by Heat Shock (*) (1995) (22)
- The effect of Ca2+ on interaction of acetylcholinesterase with subcellular fractions of electric organ tissue from the electric eel (1973) (22)
- Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite. (1977) (21)
- Immunological cross-reactivity between electric-eel acetylcholinesterase and rat-tail-tendon collagen. (1979) (21)
- Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding? (2002) (21)
- SPINE bioinformatics and data‐management aspects of high‐throughput structural biology (2006) (20)
- Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. (1999) (20)
- Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model (2019) (20)
- Refined crystal structures of “aged” and “non-aged” organophosphoryl conjugates of γ-chymotrypsin (1991) (20)
- Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases. (1996) (20)
- Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase. (2010) (20)
- Additivity of Cation−π Interactions: An ab Initio Computational Study on π−Cation−π Sandwich Complexes (2004) (20)
- Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. (2009) (20)
- Quaternary Structure of Tetrameric Acetylcholinesterase (1998) (20)
- Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly (2018) (20)
- Molecular forms of the cholinesterases inside and outside muscle endplates (1981) (20)
- Site‐directed mutagenesis of active‐site‐related residues in Torpedo acetylcholinesterase Presence of a glutamic acid in the catalytic triad (1992) (20)
- Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis (2018) (19)
- CHARACTERIZATION OF MEMBRANES OBTAINED FROM ELECTRIC ORGAN OF THE ELECTRIC EEL BY SUCROSE GRADIENT FRACTIONATION AND BY MICRODISSECTION (1977) (19)
- In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases. (2011) (19)
- A "molten globule" of Torpedo acetylcholinesterase undergoes thiol-disulfide exchange. (1994) (18)
- The multiple biological roles of the cholinesterases. (2020) (18)
- Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins. (2019) (18)
- Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. (2005) (18)
- Two partially unfolded states of torpedo californica acetylcholinesterase (1996) (17)
- Aged and non-aged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin. Preparation and comparison by 31P-NMR spectroscopy. (1989) (17)
- Control of the rate of evaporation in protein crystallization by the ‘microbatch under oil’ method (2008) (16)
- Torpedo acetylcholinesterase is inactivated by thiol reagents. (1990) (16)
- The induction of ion channels through excitable membranes by acetylcholinesterase (1980) (16)
- Recent developments in structural studies on acetylcholinesterase (2017) (16)
- Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes (2004) (16)
- Chemical modification of electric eel acetylcholinesterase by tetranitromethane. (1974) (16)
- Acetylcholinesterase in motion: Visualizing conformational changes in crystal structures by a morphing procedure (2003) (15)
- Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase (2012) (15)
- Proton-induced ion channels through lipid bilayer membranes (1983) (15)
- Acetylcholinesterase of Schistosoma mansoni: Purification and characterization (1986) (15)
- Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study. (2005) (15)
- In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications. (2016) (15)
- Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus. (1998) (14)
- Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase (2009) (14)
- Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface (1987) (14)
- Two-state transition between molten globule and unfolded states of acetylcholinesterase as monitored by electron paramagnetic resonance spectroscopy. (1994) (14)
- Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding. (1985) (14)
- Three Dimensional Structure of Acetylcholinesterase (1992) (13)
- Differential susceptibility to phosphatidylinositol-specific phospholipase C of acetylcholinesterase in excitable tissues of embryonic and adult Torpedo ocellata. (1987) (13)
- Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease. (2011) (13)
- γ-chymotrypsin is a complex of α-chymotrypsin with its own autolysis products (1991) (13)
- Interaction of electric eel acetylcholinesterase with natural and synthetic lipids (1980) (12)
- Targeted Oxidation of Torpedo californica Acetylcholinesterase by Singlet Oxygen (2011) (12)
- The Relationship between Binding Models of TMA with Furan and Imidazole and the Molecular Electrostatic Potentials: DFT and MP2 Computational Studies (2002) (12)
- Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. (2009) (11)
- Hydroxylamines and Oximes: Biological Properties and Potential Uses as Therapeutic Agents (2010) (11)
- Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy. (1989) (11)
- On the Physical Basis of Biological Signaling by Interface Pulses. (2018) (11)
- Structural studies on vertebrate and invertebrate acetylcholinesterases and their complexes with functional ligands (2000) (11)
- Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate. (2009) (11)
- The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties. (2009) (11)
- The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase. (2005) (11)
- Microenvironmental Effects on Enzyme Activity (1969) (10)
- Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC) (2005) (10)
- Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. (2012) (9)
- Assembly of Acetylcholinesterase Subunits in vitro (1998) (9)
- X-ray Structure of Human Acid-β-Glucosidase Covalently Bound to Conduritol-B-Epoxide (2005) (8)
- Effect of heat shock on acetylcholinesterase activity in chick muscle cultures (1991) (8)
- Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3 (2011) (8)
- Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin. (1991) (7)
- ONTOGENIC AND AGRANULATION-INDUCED ALTERATIONS IN CHOLINESTERASES AND IN CHOLINESTERASE mRNA IN THE RODENT CEREBELLUM (1984) (7)
- Purification of Intrinsically Disordered Proteins (2010) (7)
- Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design. (2019) (7)
- Structural proteomics and its impact on the life sciences (2008) (6)
- Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function (2020) (6)
- From Thermodynamic States to Biological Function by Einstein's Approach to Statistical Physics (2012) (6)
- Structural proteomics: from the molecule to the system (2007) (6)
- Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue. (1980) (6)
- Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor. (2020) (6)
- A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides (2020) (6)
- QUATERNARY STRUCTURE OF ELECTRIC EEL ACETYLCHOLINESTERASE (1980) (6)
- Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin. (1999) (5)
- Cryptic Catalysis and Cholinesterase Function (1992) (5)
- Molecular forms of acetylcholinesterase and pseudocholinesterase in chicken skeletal muscles: their distribution and change with muscular dystrophy. (1982) (5)
- Preface: Cholinergic Mechanisms (2017) (5)
- SOLUBILIZATION OF MEMBRANE-BOUND ACETYLCHOLINESTERASE BY A PHOSiHATIDYLINOSITOL-SPEEIFIC PHOSEHOLI PÄSE C: ENZYMATIC AND PHYSICOCHIMICAL STUDIES (1984) (5)
- Proceedings: Animal model for myasthenia gravis: acetylcholine receptor-induced myasthenia in rabbits, guinea pigs and monkeys. (1975) (5)
- New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase (1980) (5)
- Electrostatic Properties of Human Acetylcholinesterase (1995) (4)
- Effect of cholinesterase inhibitors on active potassium influx in monkey erythrocytes. (1973) (4)
- Biosynthesis of acetylcholinesterase in rat brain and Torpedo electric organ is directed by scarce mRNA species. (1983) (4)
- Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid β-Glucosidase (2007) (4)
- Structure-Function Relationships in The Binding of Reversible Inhibitors in the Active-Site Gorge of Acetylcholinesterase (1994) (4)
- The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy. (2013) (4)
- The structure of the glycosylphosphatidylinositol anchor from Torpedo californica acetylcholinesterase. (1993) (3)
- The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability. (2019) (3)
- Structural studies on acetylcholinesterase from Torpedo califor-nica (1991) (3)
- 3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7 Å Resolution (1998) (3)
- 3D Structure at 2.7 Å Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II (1998) (3)
- Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif (2021) (3)
- Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase. (2001) (3)
- STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH HUPERZINE B AT 2.35A RESOLUTION (2001) (2)
- Kinetic and structural studies on the interaction of the anti-Alzheimer drug, ENA-713, with Torpedo californica acetylcholinesterase (1998) (2)
- Crystal Structures of “Aged” Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase (1998) (2)
- Do Newly Born Orphan Proteins Resemble Never Born Proteins? A Study Using Three Deep Learning Algorithms (2023) (2)
- 3-D STRUCTURE OF ACETYLCHOLINESTERASE AND COMPLEXES OF IT WITH ANTICHOLINESTERASE AGENTS (1992) (2)
- Crystal Structure of Human Acetylcholinesterase (2015) (2)
- Ideas whose Time has Come. (1984) (2)
- A Model of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase Indicates Differences in Specificity (1992) (2)
- Action on the Electroplax of Antibiotics Affecting Membrane Permeability (1969) (2)
- Visualization of collagenase-sensitive acetylcholinesterase in isolated cardiomyocytes and in heart tissue (1988) (2)
- Site-Directed Mutagenesis of Functional Residues in Torpedo Acetylcholinesterase (1992) (2)
- Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin. (1989) (2)
- Specific Oxidation of Torpedo Californica Acetylcholinesterase by Singlet Oxygen: Identification of N-Formyl-Kynurenine Tryptophan Derivatives by Mass Spectrometry (2011) (2)
- Acetylcholinesterase Forms in Dystrophic Chickens. Normal Axonal Transport in Peripheral Nerves, Abnormal Concentration in Fast Twitch Muscles and Plasma (1979) (2)
- Structure-based high throughput virtual screening for drug discovery (2002) (2)
- Sequence Alignment of Esterases and Lipases Based on 3-D Structures of Two Members of This Family (1992) (2)
- The conjuction of a conserved electrostatic motif and a common cholinesterase fold defines a class of adhesion proteins (1997) (1)
- Oxidative stress transfers protein into “molten globule”-like state (1993) (1)
- Crystal structure of Acetylcholinesterase in complex with Xenon (2011) (1)
- The X-ray structure of human acid-beta-glucosidase : Implications for second-generation enzyme replacement therapy (2006) (1)
- Shedding UV light on the phase problem. (2006) (1)
- Structure of Membrane-bound Acetylcholinesterase (1974) (1)
- Crystal structure of the enzyme acid β-glucosidase (2013) (1)
- How Three-Fingered Snake Toxins Recognise Their Targets (1997) (1)
- XIth International Symposium on Cholinergic Mechanisms - Function and Dysfunction & 2nd Misrahi Symposium on Neurobiology (2002) (1)
- Ephraim Katchalski-Katzir: Portrait of an Israeli Scientist (1977) (1)
- Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. (2020) (1)
- CryoEM reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer (2018) (1)
- Torpedo californica acetylcholinesterase complexed with 2-PAM (2007) (1)
- HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN (2001) (1)
- NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA (1996) (1)
- NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA at 1.8A resolution (2000) (1)
- Fasciculins, cholinesterase inhibitors from mamba venoms (1998) (1)
- Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10. (2005) (1)
- Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica. (1994) (1)
- Kinetic and X-Ray Crystallographic Studies of the Binding of ENA-713 to Torpedo Californica Acetylcholinesterase (1998) (1)
- Alternative Crystal Forms of Torpedo Californica Acetylcholinesterase (1998) (1)
- Molecular Dynamics Simulations of the Interaction of Mouse and Torpedo Acetylcholinesterase with Covalent Inhibitors Explain Their Differential Reactivity: Implications for Drug Design (2019) (1)
- Structural and Functional Studies on Acetylcholinesterase (1998) (1)
- Crystallographic Studies on Complexes of Acetylcholinesterase with the Natural Cholinesterase Inhibitors Fasciculin and Huperzine A (1998) (1)
- Messenger RNA from human brain gliomas and meningiomas directs the synthesis of cholinesterase in microinjected Xenopus oocytes (1983) (1)
- An electrostatic mechanism of substrate recognition by acetylcholinesterase (1993) (1)
- An integrated model for the molecular traffic through the active site of cholinesterases (1997) (1)
- Overexpression of the extracellular and cytoplasmic domains of the Drosophila adhesion protein, gliotactin (2004) (1)
- Theoretical Insight into the Interactions of TMA-Benzene and TMA-Pyrrole with B 3 LYP Density-Functional Theory ( DFT ) and ab Initio Second Order Møller-Plesset Perturbation Theory ( MP 2 ) Calculations (2000) (1)
- Structure of the unphotolysed complex of TcAChE with 1-(2- nitrophenyl)-2,2,2-trifluoroethyl-arsenocholine at 100K (2007) (0)
- Torpedo californica acetylcholinesterase in complex with 500mM acetylthiocholine (2006) (0)
- Use of the morphing graphics technique to visualize conformational differences between acetylcholinesterases from different species and inhibitor-induced conformational changes (2004) (0)
- Crystal Structures of Complexes of E2020-Related Compounds with Torpedo Californica Acetylcholinesterase (1998) (0)
- Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (5 carbon linker) (2006) (0)
- Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3 (2011) (0)
- Laue studies on acetylcholinesterase (1996) (0)
- Native Orthorhombic form of Torpedo californica acetylcholinesterase (AChE) (2004) (0)
- Rivastigmine analogue bound to Tc ACHE. (2018) (0)
- THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE (1999) (0)
- Crystal structures of conjugates of soman with TcAChE (2007) (0)
- ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, LAUE DATA (1998) (0)
- Proteopedia: scientific wiki bridging 3D structure-function (2009) (0)
- O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX) (1999) (0)
- Torpedo acetylcholinesterase - Hg heavy-atom derivative (2006) (0)
- 3D structures of Acetylcholinesterase complexes with potential drugs for the treatment of Alzheimer's disease (2002) (0)
- acid-beta-glucosidase with N-butyl-deoxynojirimycin (2007) (0)
- Unfolding of acetylcholinesterase from Bungarus fasciatus (1997) (0)
- Quaternary ligand binding sites of acetylcholinesterase as revealed by X-ray crystallography (1993) (0)
- SUSSMAN simulation and X-ray crystallography acetylcholinesterase : Synergistic use of molecular dynamics Structure and dynamics of the active site gorge of data (2002) (0)
- THE INVOLVEMENT OF PHOSPHATIDYLINOSITOL IN THE ANCHORING OF HYDROPHOBIC FORMS OF ACETYLCHOLINESTERASE TO THE PLASMA MEMBRANE (1985) (0)
- The physiological butyrylcholinesterase tetramer is a dimer of dimers stabilized by a superhelical assembly (2018) (0)
- Crystal structure of BACE1 complexed with an inhibitor (2011) (0)
- METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN) (1999) (0)
- Selected Reading Shedding Uv Light on the Phase Problem (2006) (0)
- Torpedo acetylcholinesterase complexed with fluorophore thioflavin T (2007) (0)
- Studies on Partially Unfolded States of Torpedo californica Acetylcholinesterase (1995) (0)
- Electrostatic homology modelling of a set of ChE-like neural adhesion proteins identifies a shared ‘annular’ motif with ChEs. Structural implications for a cell-recognition role of ChEs (1998) (0)
- Non-aged form of Torpedo californica acetylcholinesterase inhibited by nerve agent tabun (2018) (0)
- Preface: Cholinergic mechanisms (2021) (0)
- Studies on the 3-D structure of Torpedo Acetylcholinesterase (1996) (0)
- X-Ray Crystallographic Studies on Acetylcholinesterase and Related Enzymes. (1999) (0)
- 3-D Structure of Acetylcholinesterase and Its Complexes with Anticholinesterase Agents (1995) (0)
- Torpedo californica acetylcholinesterase bound to uncharged hybrid reactivator 2 (2018) (0)
- Stable, high-expression variant of human acetylcholinesterase (2016) (0)
- Non-aged form of Torpedo californica acetylcholinesterase inhibited by tabun analog NEDPA bound to uncharged reactivator 1 (2018) (0)
- International Workshop on Structural and Functional Aspects of the Cholinergic Synapse Held in Jerusalem, Isreal on 30 August-4 September 1987 (1987) (0)
- COUPLING OF ACETYLCHOLINESTERASE TO THE INTERFACIAL PHASE STATE (2018) (0)
- Partially deglycosylated glucoceramidase (2006) (0)
- Protein expression for structural studies (2006) (0)
- Carbamylated T. californica acetylcholineterase bound to uncharged hybrid reactivator 1 (2018) (0)
- Miriam M Salpeter (Mika) – biographical notes (2004) (0)
- Torpedo Californica Acetylcholinesterase In Complex With A Non Hydrolysable Substrate Analogue, 4-Oxo-N,N,N- Trimethylpentanaminium - Orthorhombic space group - Dataset A at 100K (2008) (0)
- Conversion of the three-dimensional structure of acetylcholinesterase to butyrylcholine-sterase: modeling and mutagenesis (1993) (0)
- Preparative Production of Acetylcholinesterase and Paraoxonase in Procaryotic and Eucaryotic Expression in Systems (2003) (0)
- PHOTO-INDUCED RELEASE OF AN ACETYLCHOLINESTERASE INHIBITOR (2018) (0)
- ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH RIVASTIGMINE (2002) (0)
- Structure of Acetylcholinesterase Complex with (+)-Huperzine A at 2.1A Resolution (2002) (0)
- Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution (2002) (0)
- X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells (2008) (0)
- Alexander George Karczmar (1917-2017). (2017) (0)
- ACHE IN COMPLEX WITH A BIS-(-)-NOR-MEPTAZINOL DERIVATIVE (2009) (0)
- Evidence for the formation of disul®de radicals in protein crystals upon X-ray irradiation2 (2002) (0)
- Expression and Tissue Distribution of Cholinesterases Via EST Analysis (1998) (0)
- Determination by X-Ray Crystallography of the Three-Dimensional Structure of Acetylcholinesterase from Torpedo Electric Organ (1990) (0)
- NON-AGED CONJUGATE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE WITH SOMAN (ALTERNATIVE REFINEMENT) (2010) (0)
- Measuring cerebral acetylcholine esterase activity in Alzheimer dementia by PET functional parametric imaging. (2004) (0)
- A f 3-D-Galactoside Binding Protein from Electric Organ Tissue of Electrophorus electricus ( agglutination / lectin / skeletal muscle / lactose / affinity chromatography ) (0)
- Ache W. CPT-11 (2005) (0)
- ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH HUPERZINE A (1997) (0)
- AGED CONJUGATE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE WITH SOMAN (OBTAINED BY IN CRYSTALLO AGING) (2009) (0)
- Torpedo californica acetylcholinesterase in complex with a non hydrolysable substrate analogue, 4-oxo-N,N,N-trimethylpentanaminium (2006) (0)
- Biosynthesis and secretion of catal acetylcholinesterase in Xenopus ooc; microinjected with mRNA from r brain and from Torpedo electric org: (bioassay/half-life/scarce-enzyme expression) (2016) (0)
- Serum paraoxonase-1 by directed evolution at pH 6.5 in complex with 2-hydroxyquinoline (2012) (0)
- Structures of Complexes of Acetylcholinesterase with Covalently and Non-Covalently Bound Inhibitors (1995) (0)
- CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II (2001) (0)
- Non-aged form of Torpedo californica acetylcholinesterase inhibited by tabun analog NEDPA bound to uncharged reactivator 2 (2018) (0)
- Structure and interactions of a complex of snake venom toxin and acetylcholinesterase (1996) (0)
- ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA (1998) (0)
- 3-D Structures of Acetylcholinesterase and of its Complexes with Cholinergic Ligands. (1993) (0)
- The crystal structure of the complex of the anticancer prodrug CPT-11 with Torpedo acetylcholinesterase provides a molecular explanation for its cholinergic action Fast (2005) (0)
- Kinetic crystallography on cholinesterases (2004) (0)
- Reactions of human butyrylcholinesterase His-117 enzymes with carbamates (1997) (0)
- Characterization by NMR and Fluorescence Spectroscopy of Differences in the Conformation of Non-Aged and Aged Organophosphoryl Conjugates of AChE (acetylcholinesterase) (1984) (0)
- TERNARY COMPLEX OF THE AGED CONJUGATE OF TORPEDO CALIFORNICA ACEYLCHOLINESTERASE WITH SOMAN AND 2-PAM (2009) (0)
- Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution (2002) (0)
- ACHE FROM DROSOPHILA MELANOGASTER COMPLEX WITH TACRINE DERIVATIVE 9-(3-PHENYLMETHYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE (2000) (0)
- Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (RS)-Tacrine(10)-Hupyridone Inhibitor. (2005) (0)
- Recent breakthroughs in the structure/function studies of acetylcholinesterase (2017) (0)
- NON-AGED CONJUGATE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE WITH SOMAN (2009) (0)
- X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH 5N,6S-(N'-(N-OCTYL)IMINO)-6-THIONOJIRIMYCIN IN THE ACTIVE SITE (2011) (0)
- Structure of the unphotolysed complex of TcAChE with 1-(2- nitrophenyl)-2,2,2-trifluoroethyl-arsenocholine after a 9 seconds annealing to room temperature (2007) (0)
- TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH BW284C51 (2000) (0)
- STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9""-(1"",2"",3"",4""-TETRAHYDROACRIDINYL)-1,8- DIAMINOOCTANE AT 2.2A RESOLUTION (2005) (0)
- Structure oftheglycosyl-phosphatidylinositol (1993) (0)
- X-ray structure of acid-beta-glucosidase with N-octyl(cyclic guanidine)-nojirimycin in the active site (2009) (0)
- Proceedings: Thymus, acetylcholine receptor and myasthenia gravis. (1975) (0)
- APO structure of BACE1 (2011) (0)
- Acetylcholinesterase of S. mansoni (Trematode). Interaction of globular species with glycosaminoglycans (1998) (0)
- Native Torpedo californica acetylcholinesterase collected with a cumulated dose of 9400000 Gy (2008) (0)
- X-Ray Crystallographic Studies on Acetylcholinesterase and on Its Interaction with Anticholinesterase Agents. (1994) (0)
- Torpedo californica Acetylcholinesterase in Complex with Aflatoxin B1 (Orthorhombic Space Group) (2011) (0)
- Purification by Affinity Chromatography of the Molecular Forms of Acetyicholinesterase Present in Fresh Electric-Organ Tissue of Electric Eel ( N-methylacridinium / protein subunits / proteolysis / acrylamide gel electrophoresis / sucrose gradients ) (0)
- Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with N-9-(1',2',3',4'-Tetrahydroacridinyl)-1,8- diaminooctane at 2.4 angstroms resolution. (2005) (0)
- TRANSITION STATE ANALOG: ACETYLCHOLINESTERASE COMPLEXED WITH M-(N,N,N-TRIMETHYLAMMONIO)TRIFLUOROACETOPHENONE (1996) (0)
- acid-beta-glucosidase produced in carrot (2008) (0)
- Recombinant human acetylcholinesterase (2010) (0)
- Radiation damage to proteins studied by temperature-controlled cryo-crystallography (2002) (0)
- Human acetylcholinesterase I: In vitro assembly of subunits (1997) (0)
- Structure of the tetramerization domain of acetylcholinesterase: four-fold interaction of a WWW motif with a left-handed polyproline helix (2005) (0)
- Temperature-controlled crystallographic experiments on acetylcholinesterase (2000) (0)
- Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification. (2023) (0)
- Carbamylated T. californica acetylcholineterase bound to uncharged hybrid reactivator 2 (2018) (0)
- Esterases Reacting with Organophosphorus Compounds (2015) (0)
- Structure of the complex of TcAChE with 1-(2-nitrophenyl)-2,2,2- trifluoroethyl-arsenocholine after a 9 seconds annealing to room temperature, during the first 5 seconds of which laser irradiation at 266nm took place (2007) (0)
- Torpedo californica acetylcholinesterase bound to uncharged hybrid reactivator 1 (2018) (0)
- Structural Genomics and Structural Proteomics: A Global Perspective (2008) (0)
- Surface Residues Near the Peripheral Site Affect the Stability of Torpedo Acetylcholinesterase (1998) (0)
- Structural Studies on Acetylcholinesterase and Paraoxonase Directed Towards Development of Therapeutic Biomolecules for the Treatment of Degenerative Diseases and Protection Against Chemical Threat Agents (2009) (0)
- S 024 Partial unfolding of insect acetylcholinesterase : Steps toward cysteine-targeting insecticides (2018) (0)
- Activity of Torpedo Californica Acetylcholinesterase in the Crystalline State (1998) (0)
- Complex of TcAChE with galanthamine derivative (2004) (0)
- TORPEDO CALIFORNICA ACETYLCHOLINESTERASE INHIBITED BY NERVE AGENT GD (SOMAN). (1999) (0)
- Serum paraoxonase-1 by directed evolution at pH 6.5 (2012) (0)
- Chronic administration of pyridostigmine (p) and/or exhaustive exercise change morphology and physiology op rat muscle and neuromuscular junction (1985) (0)
- 3D Structure of a Complex of the Anti-Alzheimer Drug, E2020, with Acetylcholinesterase at 2.5Å Resolution (1998) (0)
- Altered activity of cholinergic enzymes in muscles and brain of the obese-diabetic (ob/ob) mouse (2004) (0)
- Evidence that the anti-Alzheimer drug, ENA-713, inhibits acetylcholinesterase by more than one mechanism (1997) (0)
- Human protein complexes involved in neurodevelopment (2009) (0)
- Structure of native TcAChE after a 9 seconds annealing to room temperature during the first 5 seconds of which laser irradiation at 266nm took place (2007) (0)
- AD Award Number : DAMD 17-021-0675 TITLE : Preparative Production of Acetylcholinesterase and Paraoxonase in Procaryotic and Eucaryotic Expression Systems (0)
- Human acetylcholinesterase II: In vivo expression and tissue distribution via est analyses (1997) (0)
- ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH NAP (2002) (0)
- Orthorhombic form of Torpedo californica acetylcholinesterase (AChE) complexed with bis-acting galanthamine derivative (2004) (0)
- Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (7 carbon linker) (2006) (0)
- AChE in complex with methylene blue (2010) (0)
- Crystal structure of the tetramerization domain of acetylcholinesterase at 2 (2004) (0)
- X-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinoline (2001) (0)
- 163D structure of mammalian paraoxonase at 2.2 Å resolution (2006) (0)
- Membrane-Promoted Unfolding of Torpedo Californica and Bungarus Fasciatus Acetylcholinesterase (1998) (0)
- ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II (1996) (0)
- Structure-Function Relationships in Acetylcholinesterase: Modelling, Mutagenesis and Comparative Studies. (1993) (0)
- The Crystallization of Acetylcholinesterase (AChE) from Torpedo Electric Organ (1991) (0)
- serum paraoxonase by directed evolution (2004) (0)
- MODELLING AND MUTAGENESIS OF BUTYRYLCHOLINESTERASE BASED ON THE X-RAY STRUCTURE OF ACETYLCHOLINESTERASE (1992) (0)
- Native acetylcholinesterase from Drosophila Melanogaster (2000) (0)
- Complex of TcAChE with bis-acting galanthamine derivative (2004) (0)
- X-RAY STRUCTURE OF AGED DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) BOUND TO ACETYLCHOLINESTERASE (1999) (0)
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