Iva Greenwald

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Iva Greenwald is affiliated with the following schools: Princeton University, Massachusetts Institute of Technology, Stanford University, Columbia University

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Iva Greenwald

Biology

#7747

World Rank

#10714

Historical Rank

Biotechnology

#206

World Rank

#208

Historical Rank

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Biology

Iva Greenwald's Degrees

PhD Biology Stanford University

Why Is Iva Greenwald Influential?

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According to Wikipedia, Iva Susan Greenwald is an American biologist who is Professor of Cell and Molecular Biology at Columbia University. She studies cell-cell interactions and cell fate specification in C. elegans. She is particularly interested in LIN-12/Notch proteins, which is the receptor of one of the major signalling systems that determines the fate of cells.

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Iva Greenwald's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Presenilin is required for activity and nuclear access of Notch in Drosophila (1999) (821)
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene (1995) (713)
LIN-12/Notch signaling: lessons from worms and flies. (1998) (588)
Intrinsic activity of the lin-12 and Notch intracellular domains in vivo (1993) (491)
Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells (1992) (442)
OrthoList: A Compendium of C. elegans Genes with Human Orthologs (2011) (390)
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. (1996) (378)
glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins (1989) (340)
lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor (1985) (321)
Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development (2004) (264)
Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. (2001) (263)
The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch (1988) (256)
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. (1997) (255)
Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision (1994) (241)
Cell autonomy of lin-12 function in a cell fate decision in C. elegans (1989) (230)
Membrane Topology of the C. elegans SEL-12 Presenilin (1996) (214)
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. (2004) (211)
Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog (2001) (202)
unc-93(e1500): A behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype. (1980) (198)
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling. (1997) (169)
Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. (1995) (167)
A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. (1999) (166)
OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes (2018) (166)
Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKM z (2009) (165)
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. (1995) (165)
Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans (1990) (164)
Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins. (1998) (163)
LIN-12/Notch Activation Leads to MicroRNA-Mediated Down-Regulation of Vav in C. elegans (2005) (159)
Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans (2002) (158)
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. (1997) (155)
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. (2001) (140)
Structure/function studies of lin-12/Notch proteins. (1994) (134)
Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. (1983) (130)
Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans. (1993) (127)
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. (2006) (117)
A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development. (1997) (114)
A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans. (1993) (109)
Development of the Vulva (1997) (109)
LIN-12/Notch signaling in C. elegans. (2005) (106)
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. (1998) (101)
A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification. (2017) (99)
The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. (1996) (96)
Notch signaling: genetics and structure. (2013) (96)
A Caenorhabditis elegans model for epithelial–neuronal transdifferentiation (2008) (95)
p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans (1999) (90)
lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans. (2005) (81)
Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans. (2003) (80)
Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. (1993) (80)
glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans. (1993) (77)
LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans (2005) (74)
Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. (2002) (74)
Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans. (1997) (73)
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans. (2000) (73)
Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans (1990) (72)
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin. (1998) (70)
LIN-12 protein expression and localization during vulval development in C. elegans. (1998) (70)
SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells (2007) (69)
lin-25, a gene required for vulval induction in Caenorhabditis elegans. (1995) (63)
A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells (2010) (62)
Genetic and phenotypic studies of hypomorphic lin-12 mutants in Caenorhabditis elegans. (1993) (59)
Evidence for Physical and Functional Association Between EMB-5 and LIN-12 in Caenorhabditis elegans (1996) (56)
Notch and the Awesome Power of Genetics (2012) (56)
Endocytosis Function of a Ligand-Gated Ion Channel Homolog in Caenorhabditis elegans (2005) (53)
Correlation of the physical and genetic maps in the lin-12 region of Caenorhabditis elegans. (1987) (52)
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. (2005) (52)
Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans (2007) (50)
The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons. (2015) (48)
Multiple roles for the E/Daughterless ortholog HLH-2 during C. elegans gonadogenesis. (2004) (47)
Spatial and temporal patterns of lin-12 expression during C. elegans hermaphrodite development. (1995) (46)
Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif. (2000) (42)
spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. (2000) (41)
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron. (2012) (39)
Spatial Regulation of lag-2 Transcription During Vulval Precursor Cell Fate Patterning in Caenorhabditis eleganslag-2 (2011) (39)
Cell-cell interactions that specify certain cell fates in C. elegans development. (1989) (37)
A visible allele of the muscle gene sup-10X of C. elegans. (1986) (36)
Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans. (1982) (36)
New Positive Regulators of lin-12 Activity in Caenorhabditis elegans Include the BRE-5/Brainiac Glycosphingolipid Biosynthesis Enzyme (2005) (33)
LIN-14 Inhibition of LIN-12 Contributes to Precision and Timing of C. elegans Vulval Fate Patterning (2010) (32)
Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans (2013) (28)
Dimerization-driven degradation of C. elegans and human E proteins (2015) (25)
Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development (1993) (24)
A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit. (1989) (23)
Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates. (1998) (23)
A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo (2016) (21)
A genetic mosaic screen of essential zygotic genes in Caenorhabditis elegans. (1991) (21)
SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans. (1999) (20)
A bHLH Code for Sexually Dimorphic Form and Function of the C. elegans Somatic Gonad (2017) (19)
A BEHAVIORAL MUTANT OF CAENORHABDZTZS ELEGANS THAT DEFINES A GENE WITH A WILD-TYPE NULL PHENOTYPE (2003) (19)
Cell Non-autonomous Function of daf-18/PTEN in the Somatic Gonad Coordinates Somatic Gonad and Germline Development in C. elegans Dauer Larvae (2019) (18)
Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans (2017) (15)
sel-11 and cdc-42, Two Negative Modulators of LIN-12/Notch Activity in C. elegans (2010) (14)
Programmed cell death in invertebrates (1984) (13)
HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis (2019) (13)
The lin‐12 locus of Caenorhabditis elegans (1987) (11)
sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans (2004) (11)
Cell fates in C. elegans: In medias ras (1990) (10)
Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites (2004) (10)
Determinants in the LIN-12/Notch Intracellular Domain That Govern Its Activity and Stability During Caenorhabditis elegans Vulval Development (2016) (9)
EMB-4: A Predicted ATPase That Facilitates lin-12 Activity in Caenorhabditis elegans (2006) (8)
Introduction to signal transduction (2005) (8)
Positive autoregulation of lag-1 in response to LIN-12 activation in cell fate decisions during C. elegans reproductive system development. (2020) (7)
Influences of LIN-12/Notch and POP-1/TCF on the Robustness of Ventral Uterine Cell Fate Specification in Caenorhabditis elegans Gonadogenesis (2015) (7)
Positive autoregulation of lag-1 in response to LIN-12 activation in cell fate decisions during C. elegans reproductive system development (2020) (6)
The genetic analysis of cell lineage in Caenorhabditis elegans (1985) (5)
WormBook: WormBiology for the 21st Century (2016) (5)
A feast of worms. (1989) (4)
Floxed exon (Flexon): A flexibly positioned stop cassette for recombinase-mediated conditional gene expression (2022) (4)
hecd-1 Modulates Notch Activity in Caenorhabditis elegans (2014) (4)
Cell-cell interactions in the nematode Caenorhabditis elegans. (1990) (3)
Genetic and molecular analysis of EGF‐related genes in Caenorhabditis elegans (1990) (3)
A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region (“NRR”)-Missense Activity in Caenorhabditis elegans (2019) (3)
SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo. (2022) (2)
Cell interactions and signal transduction in C. elegans development (1994) (2)
Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis (2022) (2)
19 Development of the Vulva (1997) (2)
Sexist ads (1986) (1)
EGFR signal transduction is downregulated in C. elegans Vulval Precursor Cells during dauer diapause. (2022) (1)
Negative feedback by conserved kinases patterns the degradation of Caenorhabditis elegans Raf in vulval fate patterning (2020) (1)
Negative feedback by conserved kinases patterns degradation of C. elegans Raf in vulval fate patterning. (2020) (1)
Correction: OrthoList: A Compendium of C. elegans Genes with Human Orthologs (2014) (1)
A Floxed exon (Flexon) approach to Cre-mediated conditional gene expression (2021) (0)
hecd-1 modulates Notch activity in C. elegans (2014) (0)
Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins (2022) (0)
Figure 1, Overview of signal transduction. (2005) (0)
Precursor Cell fate patterning in C . elegans (2017) (0)
Figure 5, NRR structure from human Notch2. (2005) (0)
CHAPTER 256 – Induction and Lateral Specification Mediated by LIN-12/Notch Proteins (2003) (0)
The C. elegans Notch proteins LIN-12 and GLP-1 are tuned to lower force thresholds for activation than Drosophila Notch (2021) (0)
[Table], Table 2. Validated targets of LIN-12 or GLP-1 (2005) (0)
[Table], Table 5. Enhancers of glp-1 gain-of-function (2005) (0)
Genetic analysis of DAF-18/PTEN missense mutants for the ability to maintain quiescence of the somatic gonad and germ line in Caenorhabditis elegans dauer larvae (2022) (0)
Figure 7, Structure of the C. elegans LAG-1/LIN-12/SEL-8 ternary complex structure bound to DNA. (2005) (0)
[Table], Table 4. Enhancers of a glp-1 hypomorph (2005) (0)
ESSENTIAL GENE OF CAENORHABDZTIS ELEGANS (1982) (0)
[Table, Modulators of lin-12 and glp-1 activity]. (2005) (0)
Figure 4, Structure of the DSL domain and EGF repeats from the human ligand Jagged1. (2005) (0)
Figure 8, Structure of dimeric human CSL-NICD-MAM ternary complexes bound to HES-1 DNA. (2005) (0)
Figure 3, EGF repeats structure from human Notch1. (2005) (0)
[Table], Table 6. Suppressors of lin-12 hypomorphs (2005) (0)
[Table], Table 1. Core components of the Notch signaling system (2005) (0)
hlh-12, a gene that is necessary and sufficient to promote migration of gonadal regulatory cells in Caenorhabditis elegans, evolved within the Caenorhabditis clade. (2021) (0)
Figure 2, Domain organization of core components from C. elegans. (2005) (0)
Figure 6, Structure of LAG-1 (CSL) bound to DNA. (2005) (0)
[Table], Table 3. Suppressors of lin-12(d) (2005) (0)
Genetic analysis of a caenorhabditis elegans muscle mutant defines a gene with a wild type null phenotype (1982) (0)

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What Schools Are Affiliated With Iva Greenwald?

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