Iwao Ojima
#76,775
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American chemist
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Iwao Ojimachemistry Degrees
Chemistry
#1192
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#1859
Historical Rank
#474
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Organic Chemistry
#149
World Rank
#190
Historical Rank
#58
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Chemistry
Iwao Ojima's Degrees
- PhD Organic Chemistry University of Tokyo
- Bachelors Chemistry University of Tokyo
Why Is Iwao Ojima Influential?
(Suggest an Edit or Addition)According to Wikipedia, Iwao Ojima is a Japanese-American chemist and university distinguished professor at the State University of New York at Stony Brook . He has been widely recognized for his seminal contributions to a range of chemical research at the multifaceted interfaces of chemical synthesis and life sciences. As rare accomplishments, he has received four National Awards from the American Chemical Society in four different fields of research. He is also serving as the director of the Institute of Chemical Biology and Drug Discovery , as well as the president of the Stony Brook Chapter of the National Academy of Inventors.
Iwao Ojima's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Catalytic Asymmetric Synthesis (1993) (2486)
- Fluorine in medicinal chemistry and chemical biology (2009) (1173)
- Transition Metal-Catalyzed Carbocyclizations in Organic Synthesis. (1996) (551)
- Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. (2008) (437)
- Recent advances in tumor-targeting anticancer drug conjugates. (2005) (408)
- Biomedical Frontiers of Fluorine Chemistry (1996) (385)
- Catalytic Asymmetric Synthesis: Ojima/Asymmetric Synthesis (2005) (361)
- Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release. (2010) (266)
- Recent Advances in the .beta.-Lactam Synthon Method (1995) (241)
- Asymmetric synthesis of building-blocks for peptides and peptidomimetics by means of the β-lactam synthon method (1997) (236)
- New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method (1992) (225)
- A common pharmacophore for cytotoxic natural products that stabilize microtubules. (1999) (219)
- Characterization of the Taxol Binding Site on the Microtubule (1999) (190)
- Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)* (2015) (185)
- Hydrosilylation of 1-hexyne catalyzed by rhodium and cobalt-rhodium mixed-metal complexes. Mechanism of apparent trans addition (1990) (174)
- REDUCTION OF CARBONYL COMPOUNDS VIA HYDROSILYLATION. 3. ASYMMETRIC REDUCTION OF KETO ESTERS VIA HYDROSILYLATION CATALYZED BY A RHODIUM COMPLEX WITH CHIRAL PHOSPHINE LIGANDS (1976) (166)
- Recent advances in catalytic asymmetric reactions promoted by transition metal complexes (1989) (163)
- Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. (2011) (150)
- Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells. (1996) (147)
- Exploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology. (2013) (145)
- Taxane anticancer agents: a patent perspective (2016) (145)
- Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenylisoserine, and its analogs via chiral 3-hydroxy-4-aryl-.beta.-lactams through chiral ester enolate-imine cyclocondensation (1991) (143)
- Guided molecular missiles for tumor-targeting chemotherapy--case studies using the second-generation taxoids as warheads. (2008) (137)
- Reduction of carbonyl compounds via hydrosilylation (1975) (129)
- Advances in the chemistry of β-lactam and its medicinal applications. (2012) (126)
- Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. (2003) (119)
- Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs (2012) (114)
- New aspects of carbonylations catalyzed by transition metal complexes (1988) (111)
- The Hydrosilylation Reaction (2004) (108)
- Chemistry and chemical biology of taxane anticancer agents. (2001) (107)
- Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids (2015) (105)
- Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III. (1997) (104)
- Recent advances in the medicinal chemistry of taxoids with novel beta-amino acid side chains. (1999) (104)
- Antithrombotic agents: from RGD to peptide mimetics. (1995) (103)
- Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia (2014) (101)
- Reduction of carbonyl compounds via hydrosilylation. 4. Highly regioselective reductions of .alpha.,.beta.-unsaturated carbonyl compounds (1982) (101)
- Asymmetric hydrogenation of prochiral olefins catalyzed by rhodium complexes with chiral pyrrolidinodiphosphines. Crucial factors for the effective asymmetric induction (1980) (100)
- Tumor specific novel taxoid-monoclonal antibody conjugates. (2002) (99)
- Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents. (2006) (98)
- Rhodium complex catalysed hydrosilylation of carbonyl compounds (1972) (97)
- Transition-metal complex catalyzed polyfluoroalkylation. I. Facile addition of polyfluoroalkyl halides to carbon-carbon multiple bonds (1984) (96)
- Use of Fluorine in the Medicinal Chemistry and Chemical Biology of Bioactive Compounds—A Case Study on Fluorinated Taxane Anticancer Agents (2004) (95)
- New and effective routes to fluoro analogs of aliphatic and aromatic amino acids (1989) (91)
- A highly efficient route to taxotere by the β-Lactam Synthon Method (1993) (85)
- Silylformylation of 1-hexyne catalyzed by rhodium-cobalt mixed-metal carbonyl clusters (1991) (83)
- The reactions of hydrosilanes with trifluoropropene and pentafluorostyrene catalyzed by ruthenium, rhodium and palladium complexes (1984) (82)
- Design, synthesis, and biological evaluation of new-generation taxoids. (2008) (82)
- Azetidines and bisazetidines. Their synthesis and use as the key intermediates to enantiomerically pure diamines, amino alcohols, and polyamines (1991) (80)
- Discovery of anti-TB agents that target the cell-division protein FtsZ. (2010) (79)
- Silicon-initiated carbonylative carbotricyclization and [2+2+2+1] cycloaddition of enediynes catalyzed by rhodium complexes. (2005) (78)
- Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation. (2015) (77)
- Recent Advances in Tumor-Targeting Anticancer Drug Conjugates (2005) (76)
- Reduction of Carbonyl Compounds with Various Hydrosilane-Rhodium(I) Complex Combinations (1972) (75)
- Rhodium-Catalyzed Cyclohydrocarbonylation: Application to the Synthesis of (+)-Prosopinine and (−)-Deoxoprosophylline† (1998) (75)
- The action of tris(triphenylphosphine)chlororhodium on polyhydromonosilanes (1973) (74)
- Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance. (2001) (74)
- Unique Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology (2009) (73)
- Silylcarbocyclization reactions catalyzed by rhodium and rhodium-cobalt complexes (1992) (73)
- Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents. (2006) (73)
- Overcoming Multidrug Resistance in Taxane Chemotherapy (2002) (72)
- Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation. (2006) (69)
- Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. (2016) (68)
- Recent advances in the chemistry and biology of new generation taxoids. (2009) (68)
- New and effective route to β-lactams. The reaction of ketene silyl acetals with schiff bases promoted by titanium tetrachloride (1977) (67)
- Macrocycle Formation by Ring-Closing Metathesis. Application to the Syntheses of Novel Macrocyclic Taxoids (2000) (67)
- FtsZ: a novel target for tuberculosis drug discovery. (2007) (67)
- Synthesis of new chiral monodentate phosphite ligands and their use in catalytic asymmetric hydrogenation. (2003) (66)
- Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus. (2008) (66)
- A Novel Approach to the Study of Solution Structures and Dynamic Behavior of Paclitaxel and Docetaxel Using Fluorine-Containing Analogs as Probes (1997) (64)
- Synthesis and structure-activity relationships of new second-generation taxoids. (1999) (64)
- Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity. (1997) (63)
- New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations. (2004) (63)
- Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. (2005) (63)
- Drug resistance mechanisms and novel drug targets for tuberculosis therapy. (2017) (62)
- Modern natural products chemistry and drug discovery. (2008) (61)
- SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents. (2013) (60)
- New approaches to the asymmetric synthesis of non-proteinogenic α-amino acids and dipeptides through chiral β-lactam intermediates (1988) (60)
- Hydrosilylation of α,β-unsaturated nitriles and esters catalyzed by tris (triphenylphosphine)chlororhodium (1976) (60)
- Rhodium-catalyzed silylcarbocyclization (SiCaC) and carbonylative silylcarbocyclization (CO-SiCaC) reactions of enynes. (2002) (60)
- New and Efficient Route to Pipecolic Acid Derivatives by Means of Rh-Catalyzed Intramolecular Cyclohydrocarbonylation (1995) (59)
- A highly epothilone B–resistant A549 cell line with mutations in tubulin that confer drug dependence (2005) (59)
- New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells (2010) (58)
- Asymmetric synthesis with chiral β-lactams. Highly stereoselective alkylation and aldol reaction of a chiral 3-amino-4-styryl-β-lactam (1990) (58)
- Hydroformylation of fluoro olefins, RfCH:CH2, catalyzed by group VIII transition-metal catalysts. Crucial factors for extremely high regioselectivity (1987) (58)
- Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy (2014) (58)
- Effective biomimetic route to D-(+)-pantothenate using asymmetric hydrogenation catalyzed by a chiral rhodium complex in the key step (1978) (57)
- Stereoselective Reduction of Ketones with Hydrosilane-Rhodium(I) Complex Combinations (1972) (57)
- Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. (2001) (57)
- Asymmetric alkylations of a phenylalanylglycinate equivalent. Novel route to dipeptides bearing .alpha.-alkyl-.alpha.-amino acid residues (1990) (56)
- Regioselective hydroesterification and hydrocarboxylation of 3,3,3-trifluoropropene and pentafluorostyrene catalyzed by phosphine-palladium complex (1983) (55)
- Drug discovery targeting cell division proteins, microtubules and FtsZ. (2014) (55)
- Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents. (2012) (55)
- Efficient syntheses of crispine A and harmicine by RH-catalyzed cyclohydrocarbonylation. (2009) (55)
- HOMOGENEOUS CATALYSIS OF MIXED-METAL SYSTEMS. HIGHLY REGIOSELECTIVE HYDROFORMYLATION-AMIDOCARBONYLATION OF A FLUORO OLEFIN CATALYZED BY Co-Rh MIXED-METAL SYSTEMS. OBSERVATION OF CoRh(CO)//7 CATALYSIS. (1988) (54)
- Extremely Chemoselective Silylformylation and Silylcarbocyclization of Alkynals (1994) (54)
- Anti‐proliferative activity of a new class of taxanes (14β‐hydroxy‐10‐deacetylbaccatin III derivatives) on multidrug‐resistance‐positive human cancer cells (1997) (53)
- Recent progress in the strategic incorporation of fluorine into medicinally active compounds. (2019) (51)
- Silylcarbobicyclization of 1,6-Diynes: A Novel Catalytic Route to Bicyclo[3.3.0]octenones (1994) (51)
- Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023 (2004) (50)
- Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to nitroalkenes. (2004) (50)
- Remarkable dependency of regioselectivity on the catalyst metal species in the hydroformylation of trifluoropropene and pentafluorostyrene (1982) (50)
- New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells. (1998) (49)
- Asymmetric synthesis of β-lactams. II. Highly effective asymmetric induction by means of “titanium template” (1980) (49)
- Identification of the domains of photoincorporation of the 3'- and 7-benzophenone analogues of taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein. (1998) (49)
- Therapeutic potential of FtsZ inhibition: a patent perspective (2011) (49)
- Homogeneous asymmetric catalysis by means of chiral rhodium complexes (1984) (49)
- Trifluoromethyl- and difluoromethyl-β-lactams as useful building blocks for the synthesis of fluorinated amino acids, dipeptides, and fluoro-taxoids (2004) (49)
- Synthesis of chiral oligopeptides by means of catalytic asymmetric hydrogenation of dehydropeptides (1984) (49)
- Synthesis and evaluation of 6-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine as a PET tracer for nicotinic acetylcholine receptors (2000) (47)
- Regioselective hydrosilylation of 1,3-dienes catalyzed by phosphine complexes of palladium and rhodium (1978) (46)
- The role of individual caspases in cell death induction by taxanes in breast cancer cells (2015) (46)
- Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids (2018) (45)
- Structural requirements of taxoids for nitric oxide and tumor necrosis factor production by murine macrophages. (1996) (44)
- New synthesis of nitrogen heterocycles through amide-directed hydrocarbonylation of alkenamides catalyzed by rhodium complexes (1991) (44)
- Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells (2005) (43)
- SYNTHESIS OF CHIRAL DIPEPTIDES BY MEANS OF ASYMMETRIC HYDROGENATION OF DEHYDRO DIPEPTIDES (1982) (42)
- Silylcarbocyclizations of 1,6-Diynes (1998) (42)
- Selective reduction of α,β-unsaturated terpene carbonyl compounds using hydrosilane-rhodium(I) complex combinations (1972) (42)
- Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. (2014) (41)
- Asymmetric synthesis of 1-vinyltetrahydroisoquinoline through Pd-catalyzed intramolecular allylic amination (2007) (41)
- Enantiopure fluorine-containing taxoids: potent anticancer agents and versatile probes for biomedical problems (1999) (41)
- Asymmetric synthesis of β-lactams. I. The reaction of dimethylketene silyl acetal with (S)-alkylidene(1-arylethyl)amines promoted by titanium tetrachloride (1980) (41)
- Syntheses and biological activity of C-3'-difluoromethyl-taxoids. (2000) (41)
- A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein. (1995) (41)
- Antibody–cytotoxic agent conjugates for cancer therapy (2005) (41)
- Recent advances in the new generation taxane anticancer agents. (2005) (41)
- Rhodium and cobalt carbonyl clusters Rh4(CO)12, Co2Rh2(CO)12, and Co3Rh(CO)12 as effective catalysts for hydrosilylation of isoprene, cyclohexanone, and cyclohexenone (1991) (40)
- Remarkable effects of lone pair-lone pair interactions on the extremely stereoselective [2 + 2] cycloaddition of azidoketene to chiral 3-imino-.beta.-lactams (1987) (40)
- An Effective and Convenient Route to 5-Trifluoromethyl-5,6-dihydrouracils and their Thio Derivatives (1984) (40)
- Highly efficient synthesis of azabicyclo[x.y.0]alkane amino acids and congeners by means of Rh-catalyzed cyclohydrocarbonylation. (2007) (40)
- Silylformylation catalyzed by Rh and Rh-Co mixed metal complexes and its application to the synthesis of pyrrolizidine alkaloids (1993) (39)
- Antitumor Efficacy of Taxane Liposomes on a Human Ovarian Tumor Xenograft in Nude Mice (1995) (39)
- New synthetic route to N-acyl-α-amino acids via amidocarbonylation by means of homogeneous binary catalyst systems (1985) (39)
- Tumor-targeting drug delivery of new-generation taxoids. (2012) (39)
- New and direct route to 5-trifluoromethyl-5,6-dihydrouracils by means of palladium complex catalyzed “ureidocarbonylation” of 2-bromo-3,3,3-trifluoropropene (1982) (39)
- Catalytic asymmetric transformations with fine-tunable biphenol-based monodentate ligands (2006) (38)
- Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. (2014) (38)
- The Hydroformylation Reaction (2003) (38)
- Syntheses and Structure-Activity Relationships of Novel 3'-Difluoromethyl and 3'-Trifluoromethyl-Taxoids. (2008) (37)
- Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors (2000) (37)
- Extremely Regioselective Intramolecular Silylformylation of Alkynes (1995) (37)
- Effective homogeneous hydrogenation of α-keto esters catalysed by neutral rhodium(I) complexes with phosphine ligands and application to the asymmetric synthesis of lactates (1977) (36)
- Nanoemulsion formulation of a novel taxoid DHA-SBT-1214 inhibits prostate cancer stem cell-induced tumor growth. (2017) (36)
- A new route to metal chelates of dimethyldithiocarbamate and their far infrared spectra (1970) (36)
- Effective route to azetidines from azetidin-2-ones with the use of hydroalanes as specific reducing agents (1983) (36)
- Synthesis of novel C2-C3'N-linked macrocyclic taxoids by means of highly regioselective Heck macrocyclization. (2003) (36)
- A novel method for the reduction of schiff bases using catalytic hydrosilylation (1973) (35)
- Asymmetric synthesis with chiral .beta.-lactams. .alpha.-Substituted aromatic .alpha.-amino acids and their derivatives through highly stereoselective alkylations (1988) (35)
- The stereochemistry of the addition of hydrosilanes to alkyl acetylenes catalyzed by tris(triphenylphosphine)-chlororhodium (1974) (35)
- Synthesis of Heterocycles Through Hydrosilylation, Silylformylation, Silylcarbocyclization and Cyclohydrocarbonylation Reactions (2006) (35)
- Novel amide-directed hydrocarbonylations and double carbonylation of N-allylamides (1988) (35)
- Tumor-specific novel taxoid-monoclonal antibody conjugates. (2004) (35)
- Recent Advances in the Study of the Bioactive Conformation of Taxol (2009) (34)
- Remarkable effects of a pentafluorophenyl group on the stereoselective reactions of a chiral iron acyl complex (1988) (34)
- GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure. (1998) (34)
- Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin. (2009) (34)
- Rhodium-Catalyzed Novel Carbonylative Carbotricyclization of Enediynes (2000) (34)
- Extremely stereoselective alkylation of 3-siloxy-β-lactams and its applications to the asymmetric syntheses of novel 2-alkylisoserines, their dipeptides, and taxoids (1998) (33)
- Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugates. (2015) (33)
- A NEW ROUTE TO AMINONITRILES VIA CYANOSILYLATION OF SCHIFF BASES AND OXIMES (1975) (33)
- Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents. (2005) (33)
- SB-RA-2001 Inhibits Bacterial Proliferation by Targeting FtsZ Assembly (2014) (33)
- New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method (1992) (33)
- Rhodium-Catalyzed Intramolecular Silylcarbotricyclization (SiCaT) of Triynes (1999) (33)
- Syntheses of new fluorine-containing taxoids by means of β-Lactam Synthon Method (1996) (33)
- Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis. (2002) (32)
- Anticancer Agents: Frontiers in Cancer Chemotherapy (2001) (32)
- Fatty acid–binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation (2018) (32)
- A novel route to silylthioethers (1973) (32)
- Asymmetric synthesis of dipeptides by means of homogeneous hydrogenation catalyzed by chiral rhodium complexes (1980) (31)
- Synthesis and biological activity of novel 3′-trifluoromethyl taxoids (1997) (31)
- Novel [2 + 2 + 2 + 1] cycloaddition of enediynes catalyzed by rhodium complexes. (2004) (31)
- Direct perfluoroalkylation of functionalized benzenes with perfluoroalkyl halides and copper bronze (1983) (31)
- Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery (2018) (31)
- Syntheses and Evaluation of Novel Fatty Acid Second‐Generation Taxoid Conjugates as Promising Anticancer Agents. (2006) (31)
- Synthesis of pyrrolizidine alkaloids via rhodium-catalyzed silylformylation and amidocarbonylation (1993) (31)
- New and Efficient Coupling Method for the Synthesis of Peptides Bearing the Norstatine Residue and Their Analogs (1994) (30)
- Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes (2006) (30)
- Syntheses of nitrogen heterocycles by means of amine-directed carbonylation and hydrocarbonylation☆ (1993) (30)
- N-carbamoyl-4-diphenylphosphino-2-diphenylphosphinomethylpyrrolidines(CAPP). Efficient new chiral ligands for asymmetric hydrogenation (1980) (30)
- Recent strategies in the development of taxane anticancer drugs (2000) (30)
- Establishment of Highly Tumorigenic Human Colorectal Cancer Cell Line (CR4) with Properties of Putative Cancer Stem Cells (2014) (30)
- Recent advances in the medicinal chemistry of taxoid anticancer agents (1999) (30)
- Prostate Cancer Stem Cell-Targeted Efficacy of a New-Generation Taxoid, SBT-1214 and Novel Polyenolic Zinc-Binding Curcuminoid, CMC2.24 (2013) (30)
- Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells. (2009) (30)
- Reduction of isocyanates and carbodiimides via hydrosilylation (1977) (30)
- Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances. (2014) (29)
- Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. (2008) (29)
- Benzimidazole-based antibacterial agents against Francisella tularensis. (2013) (29)
- Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel). (1994) (29)
- The Future of Antifungal Drug Therapy: Novel Compounds and Targets (2020) (29)
- Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton. (2004) (28)
- Recent Advances in Hydrosilylation and Related Reactions (1999) (28)
- Diels-Alder reactions of (trifluoromethyl)ethene and (trifluoromethyl)styrenes with functionalized butadienes (1982) (28)
- Second generation taxanes: from the natural framework to the challenge of drug resistance. (2003) (28)
- Reactions of ketene silyl acetals with imine-complexes of titanium tetrachloride. New and convenient routes to 5,6-dihydro-2-pyridones and 5-amino-2-alkenoates (1987) (28)
- Design and synthesis of new fluorinated ligands for the rhodium-catalyzed hydroformylation of alkenes in supercritical CO2 and fluorous solvents (2001) (28)
- Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators. (2004) (28)
- Synthesis of novel 3'-trifluoromethyl taxoids through effective kinetic resolution of racemic 4-CF3-beta-lactams with baccatins. (1997) (27)
- A Facile Synthesis of trans-β-Trifluoromethylstyrene, trans-2,3,4,5,6-Pentafluorostilbene and their Derivatives (1981) (27)
- α-Silylpropionitriles: A new reagent for the synthesis of α,β-unsaturated nitriles (1974) (27)
- Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine. (2013) (27)
- Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies. (2012) (27)
- CHEMOSELECTIVE REACTIONS OF ALLYLSILANES WITH 1,1-DIMETHOXYBUTAN-3-ONE AND 1,1-DIMETHOXYPROPAN-2-ONE (1978) (27)
- Synthesis and biological activity of 3′-alkyl- and 3′-alkenyl-3′-dephenyldocetaxels (1994) (27)
- Recent Advances in the Hydrosilylation and Related Reactions (2009) (27)
- Transition-metal complex catalyzed polyfluoroalkylation. II. Novel and convenient route to 3-polyfluoroalkylprop-1-enes through the reaction of polyfluoroalkyl halides with allylsilanes (1984) (26)
- Modern molecular approaches to drug design and discovery. (2008) (26)
- Efficient Asymmetric Syntheses of β-Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Application to the Syntheses of Novel Isoserines and Taxoids (1998) (26)
- New and efficient synthesis of azabicyclo[4.4.0]alkane amino acids by Rh-catalyzed cyclohydrocarbonylation. (2002) (26)
- Caspase-2 is involved in cell death induction by taxanes in breast cancer cells (2013) (26)
- Amide-directed hydrocarbonylation of N-alkenylamides and α-alkenyllactams (1991) (26)
- One-step formation of fused tetracyclic skeletons from cyclohexene-diynes and carbon monoxide through Rh(I)-catalyzed [2 + 2 + 2 + 1] cycloaddition reaction. (2009) (25)
- Structure-activity relationships of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III. (1994) (25)
- ASYMMETRIC SYNTHESES OF α-AMINONITRILES VIA CYANOSILYLATION OF SCHIFF BASES (1975) (25)
- Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells (2011) (25)
- Reactions of Diarylphosphines, Their Oxides and Sulfides with Isothiocyanates and Thiocyanic Acid (1969) (25)
- Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice. (1995) (25)
- New routes to nitrogen heterocycles through intramolecular amidocarbonylation of alkenamides catalyzed by rhodium complexes (1989) (25)
- The asymmetric hydrogenation of α-keto esters catalyzed by rhodium(I) complexes with chiral diphosphine ligands. On the catalytic cycles and the mechanism of asymmetric induction (1980) (25)
- Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions (2017) (25)
- Structural significance of the acyl group at the C‐10 position and the A ring of the taxane core of paclitaxel for inducing nitric oxide and tumor necrosis factor production by murine macrophages (2000) (25)
- Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms (2017) (25)
- Novel and convenient route to substituted succinates. The dimerization of ketene silyl acetals promoted by titanium tetrachloride (1977) (25)
- Synthesis and Biological Evaluation of Novel 3'-Difluorovinyl Taxoids. (2012) (24)
- Direct conversion of allylic alcohols into N-acyl-α-amino acids by catalytic amidocarbonylation by means of homogeneous binary systems (1982) (24)
- Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery. (2013) (24)
- Rhodium(I)‐Catalyzed Cycloisomerization and Cyclotrimerization Reactions (2005) (24)
- Efficient syntheses of functionalized piperidines through extremely regioselective Rh-catalyzed cyclohydrocarbonylation of amido-ω,ω′-dienes (1998) (24)
- Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids. (2002) (24)
- Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique (1997) (23)
- Bimetallic synergism in alkyne silylformylation catalyzed by a cobalt-rhodium mixed-metal cluster (2006) (23)
- Mechanism of amidocarbonylation : a stereochemical approach (1990) (23)
- Selenium dioxide oxidation of 3-methyl-4,5,6,7-tetrafluoroindoles: an efficient route to tetrafluoro analogs of 3-formyl and 3-acetoxymethylindole systems (1984) (23)
- Coupling reactions of vinylketene silyl acetals promoted by titanium tetrachloride (1983) (23)
- Asymmetric Hydrosilylation by Means of Homogeneous Catalysts with Chiral Ligands (1977) (23)
- Catalytic asymmetric synthesis of peptides on polymer support (1994) (23)
- Reactions of Co2Rh2(CO)12 with isocyanides and 1-alkynes. Characterization of new isocyanide and 1-alkyne complexes of Co-Rh mixed-metal systems and the structures of [Rh(C.tplbond.N-C6H3Me2-2,6)4][Co(CO)4] and Co2Rh2(CO)7(.mu.-CO)2(.mu.4,.eta.2-HC.tplbond.CBun)(PPh3) (1991) (22)
- NEW CASCADE SILYLCARBOCYCLIZATION (SICAC) OF ENEDIYNES (1996) (22)
- New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase. (2015) (22)
- Stereochemistry of the regiospecific hydrosilylation of isoprene catalyzed by a phosphine-palladium complex (1977) (22)
- HIGHLY EFFECTIVE CATALYTIC ASYMMETRIC SYNTHESIS OF R-(−)-PANTOLACTONE (1978) (22)
- Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids (1998) (22)
- Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel. (2010) (22)
- Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems. (2015) (21)
- N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs (1993) (21)
- Asymmetric reduction of α-keto esters via hydrosilylation catalyzed by a rhodium(I) complex with chiral phosphin ligands (1974) (21)
- Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery (2018) (21)
- Reactions of triethylsilyl thiophenoxide with ketones having an electron-with-drawing group on the α-carbon (1973) (21)
- Catalytic asymmetric syntheses of R(−)- and S(+)-pantolactone☆ (1977) (21)
- 4 – Asymmetric Hydrosilylation and Hydrocarbonylation (1985) (21)
- Guided Molecular Missiles for Tumor-Targeting Chemotherapy—Case Studies Using the Second-Generation Taxoids as Warheads (2008) (21)
- Asymmetric alkylation of chiral .beta.-lactam ester enolates. A new approach to the synthesis of .alpha.-alkylated .alpha.-amino acids (1987) (20)
- In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis. (2014) (20)
- SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. (2018) (20)
- Syntheses of N-silylformamidines by the hydrosilylation of carbodiimides (1974) (20)
- Acid-catalyzed ring opening reactions of episulfoxides (1972) (20)
- Medicinal Chemistry and Chemical Biology of New Generation Taxane Antitumor Agents (2002) (20)
- Structural significance of the benzoyl group at the C-3'-N position of paclitaxel for nitric oxide and tumor necrosis factor production by murine macrophages. (1998) (20)
- Recent Advances in Rhodium-Catalyzed Cyclization Reactions (2002) (20)
- Recent advances in cyclohydrocarbonylation reactions (2005) (19)
- Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth (2019) (19)
- Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate. (2015) (19)
- A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis (2014) (19)
- A CONVENIENT ROUTE TO AMINOSILANES USING HYDROSILANE-RHODIUM(I) COMPLEX COMBINATIONS (1973) (19)
- Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids. (2008) (19)
- New and Efficient Catalytic Route to Bicyclo[3.3.0]octa-1,5-dien-3-ones (1996) (19)
- Synthesis of chiral tripeptides by asymmetric hydrogenation of dehydrotripeptides. Remarkable effects of N-protecting groups on stereoselectivity and reactivity (1982) (19)
- Rhodium-catalyzed cyclohydrocarbonylation approach to the syntheses of enantiopure homokainoids. (2007) (19)
- Formal enantioselective total synthesis of schulzeines A-C via Pd-catalyzed intramolecular asymmetric allylic amination. (2011) (18)
- Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein. (2018) (18)
- Oxidative Dimerization of Lithium-Enolates of Esters Promoted by Titanium Tetrachloride (1992) (18)
- Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model. (2015) (18)
- ASYMMETRIC REDUCTION OF KETONES VIA HYDROSILYLATION CATALYZED BY A RHODIUM(I) COMPLEX WITH CHIRAL PHOSPHINE LIGANDS (1973) (18)
- Reactions of Diphenylphosphinothioyl Isothiocyanate and Related Compounds with Some Nucleophiles and Carbodiimides (1973) (18)
- Synthesis and biological activity of 14-hydroxydocetaxel (1994) (18)
- The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. (2017) (18)
- Hydrogel microstructure live-cell array for multiplexed analyses of cancer stem cells, tumor heterogeneity and differential drug response at single-element resolution. (2016) (17)
- New Weapons in the Fight Against Cancer. (1998) (17)
- SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells (2017) (17)
- Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells. (2003) (17)
- An Improved Synthesis of a Hydroxymethyl Tricyclic Ketone from Cyclohexanone, the Key Processes for the Synthesis of a Highly Potent Anti-inflammatory and Cytoprotective Agent (2013) (16)
- Electronic effects on the regio- and enantioselectivity of the asymmetric aminohydroxylation of O-substituted 4-hydroxy-2-butenoates. (2002) (16)
- SYNTHESIS OF OPTICALLY PURE ENKEPHALIN ANALOG, [D-Ala2, Leu5-ol]ENKEPHALIN, USING CHIRAL β-LACTAMS AS SYNTHETIC INTERMEDIATES (1982) (16)
- Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere (1994) (16)
- Homogeneous mixed-metal catalyst systems: new and effective routes to N-acyl-α-amino acids via carbonylations (1986) (16)
- Synthesis of Enkephalin analogs via asymmetric hydrogenation of dehydropeptide building blocks (1983) (16)
- Syntheses of a New Series of Transition Metal Chelates of Diphenylphosphinothioylthiourea Anion (1971) (15)
- New cyclization reactions in organic syntheses (2002) (15)
- Convenient Synthesis of β-Lactams by the Reaction of Ketene Silyl Acetals with Schiff Bases Promoted by Titanium(IV) Chloride (1981) (15)
- Synthesis of novel chiral bisazetidines by the hydroalane reduction of bis-beta-lactams (1985) (15)
- Novel route to hydroxy(keto)ethylene dipeptide isosteres through the reaction of N-tBOC-β-lactams with enolates (1995) (15)
- Effective method for the asymmetric synthesis of bis-β-lactams by the cycloaddition of azidoketen to benzylideneamines bearing a chiral β-lactam backbone (1981) (15)
- EFFECTIVE ASYMMETRIC HYDROGENATION OF ITACONIC ACID CATALYZED BY NEUTRAL AND CATIONIC RHODIUM(I) COMPLEXES WITH CHIRAL PYRROLIDINODIPHOSPHINE LIGAND (1978) (15)
- Reaction of (bromodifluoromethyl)phenyldimethylsilane with organometallic reagents (1981) (15)
- Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies. (2004) (15)
- Recent strategies for the treatment of multi-drug resistance in cancer cells (1998) (15)
- New approaches to the asymmetric synthesis of dipeptide isosteres via β-Lactam Synthon Method (1998) (15)
- Organometallic chemistry and homogeneous catalysis of Rh and Rh-Co mixed metal carbonyl clusters (1992) (15)
- Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic beta-lactams with baccatins. (2000) (15)
- New potent enkephalin analogs containing trifluoromethylamino acid residues (1992) (15)
- 3-TMS-cyclopentene-1 a new reagent for the synthesis of cyclopentene derivatives (1977) (15)
- The synthesis and evaluation of 12,13-benzodesoxyepothilone B: A highly convergent route (1999) (14)
- REDUCTION OF CARBONYL COMPOUNDS VIA HYDROSILYLATION PART 1, HYDROSILYLATION OF CARBONYL COMPOUNDS CATALYZED BY TRIS(TRIPHENYLPHOSPHINE)CHLORORHODIUM (1975) (14)
- Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ. (2017) (14)
- Asymmetric addition of allyltrimethylsilane to (–)-menthyl pyruvate and phenylglyoxylate (1976) (14)
- Novel and effective routes to optically pure amino acids, dipeptides, and their derivatives viaβ-lactams obtained through asymmetric cycloaddition (1987) (14)
- On the mechanism of silylformylation catalyzed by Rh-Co mixed metal complexes (1998) (14)
- Enantioselective synthesis of 1-vinyltetrahydroisoquinolines via Pd-catalyzed intramolecular asymmetric allylic amination reactions (2011) (14)
- Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells (2012) (14)
- Extremely Regioselective Intramolecular Silylformylation of Bis(silylamino)alkynes (1999) (13)
- Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A. (2015) (13)
- β-LACTAM AS SYNTHETIC INTERMEDIATE: SYNTHESIS OF LEUCINE-ENKEPHALIN (1981) (13)
- Advances in the Use of Enantiopure β-Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests (2012) (13)
- New photoaffinity analogs of paclitaxel. (1999) (13)
- A new potent inhibitor for angiotensin converting enzyme: (R,S)-captopril-F3 (1991) (13)
- Reaction of trimethylsilyl cyanide with isocyanates and carbodiimides (1979) (13)
- Reactions of carbenes bearing sulphide linkages at the δ-position (1972) (13)
- Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216 (2016) (13)
- SELECTIVE ASYMMETRIC REDUCTION OF α,β-UNSATURATED KETONES VIA HYDROSILYLATION CATALYZED BY RHODIUM(I) COMPLEXES WITH CHIRAL PHOSPHINE LIGANDS (1975) (13)
- SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents. (2019) (13)
- ASYMMETRIC REDUCTION OF KETONES VIA HYDROSILYLATION CATALYZED BY A RHODIUM(I) COMPLEX WITH CHIRAL PHOSPHINE LIGANDS. II. ON THE MECHANISM OF THE INDUCTION OF ASYMMETRY (1974) (13)
- ASYMMETRIC CROSS ALDOL SYNTHESIS. ASYMMETRIC ADDITION OF SILYL ENOL ETHER AND KETENE SILYL ACETAL TO α-KETO ESTERS (1977) (12)
- Extremely stereoselective and stereospecific reductive cleavage of .beta.-lactams. A highly efficient route to labeled homochiral peptides (1986) (12)
- Recent Advances in the New Generation Taxane Anticancer Agents (2005) (12)
- Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity. (2016) (12)
- Targeted and armed oncolytic adenovirus via chemoselective modification. (2011) (12)
- Intramolecular reactions of α- and β-allylthioalkylcarbenes (1972) (11)
- Contribution of diacylglycerol lipase β to pain after surgery (2018) (11)
- A novel series of transition-metal chelates of diphenylphosphinothioylthiourea anion (1969) (11)
- Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-Catalyzed [2+2+2+1] and [2+2+2] Cycloadditions of o-Phenylenetriynes with and without CO. (2018) (11)
- Novel Taxoid-Based Tumor-Targeting Drug Conjugates. (2009) (11)
- Silylcyclocarbonylation (SiCCa) of alkynylamines catalyzed by rhodium complexes (1996) (11)
- Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)amino]acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen (2014) (11)
- A novel route to dipeptide and its derivative by means of the palladium catalyzed facile cleavage of 1-(1-methoxycarbonyl)alkyl-3-substituted-4-arylazetidin-2-ones (1981) (10)
- A novel route to formamides and their derivatives. Reduction of isocyanates via hydrosilylation catalyzed by palladium (1973) (10)
- Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents (2021) (10)
- Synthesis of chiral biphenol-based diphosphonite ligands and their application in palladium-catalyzed intermolecular asymmetric allylic amination reactions. (2011) (10)
- Fluoro‐Taxoid Anticancer Agents (2009) (10)
- Desymmetrization of 4-dimethylsiloxy-1,6-heptadiynes through sequential double silylformylation. (2001) (10)
- Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides. (2001) (10)
- Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes (2012) (10)
- Biodistribution and Pharmacokinetic Evaluations of a Novel Taxoid DHA-SBT-1214 in an Oil-in-Water Nanoemulsion Formulation in Naïve and Tumor-Bearing Mice (2018) (10)
- Substituents at the C3′ and C3′N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel (2018) (10)
- Reactions of hydropolysilanes with alcohols catalysed by tris(triphenylphosphine)chlororhodium (1973) (10)
- Inexpensive chemical method for preparation of enantiomerically pure phenylalanine (2014) (10)
- The Intramolecular Participation of Sulfide Linkage on the Reactivity of Carbenes and Diazoalkanes. II. Alkylcarbenes and Diazoalkanes Bearing Arylthio and Allylthio Groups on β-Carbon (1973) (9)
- Drug Conjugates with Polyunsaturated Fatty Acids (2011) (9)
- Microwave-assisted Diels–Alder reactions between Danishefsky's diene and derivatives of ethyl α-(hydroxymethyl)acrylate. Synthetic approach toward a biotinylated anti-inflammatory monocyclic cyanoenone (2013) (9)
- Erratum for Mor et al., “Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids” (2018) (9)
- Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-Based Screening (2019) (9)
- Great Challenges in Organic Chemistry (2017) (9)
- SYNTHESIS OF CHIRAL DEPSIPEPTIDE BUILDING BLOCK BY THE ASYMMETRIC REDUCTION OF N-(α-KETOACYL)-α-AMINO ESTERS (1981) (9)
- Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel–microtubules interactions (2000) (9)
- Design, synthesis and SAR study of 3rd-generation taxoids bearing 3-CH3, 3-CF3O and 3-CHF2O groups at the C2-benzoate position. (2019) (9)
- Recent Advances in the -Lactam Synthon Method (2010) (9)
- The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel. (2001) (9)
- Endocannabinoid metabolism and transport as targets to regulate intraocular pressure. (2020) (9)
- Asymmetric Carbon-Carbon Bond-Forming Reactions (2010) (8)
- Homogeneous Asymmetric Hydrogenation and Hydrosilylation of Keto Esters Catalyzed by Chiral Rhodium Complexes (1978) (8)
- THE FORMATION OF SILYLRHODIUM COMPLEXES BY OXIDATIVE ADDITION OF HYDROSILANES TO HYDRIDOTETRAKIS(TRIPHENYLPHOSPHINE) RHODIUM(I). A HOMOGENEOUS CATALYST FOR HYDROSILATION (1975) (8)
- Design, synthesis and SAR of RGD peptide hybrids as highly efficient inhibitors of platelet aggregation (1995) (8)
- 31P NMR STUDIES ON THE MECHANISM OF ASYMMETRIC HYDROGENATION CATALYZED BY RHODIUM(I) COMPLEXES WITH CHIRAL PYRROLIDINODIPHOSPHINE LIGAND (1978) (8)
- ASYMMETRIC HYDROGENATION OF α-ACYLAMINOCINNAMIC ACID CATALYZED BY CHIRAL RHODIUM COMPLEXES. REMARKABLE EFFECTS OF HYDROGEN PRESSURE ON STEREOSELECTIVITY (1979) (7)
- A novel taxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel-resistance in breast cancer cells. (2020) (7)
- 2 – Transition Metal Hydrides: Hydrocarboxylation, Hydroformylation, and Asymmetric Hydrogenation (1995) (7)
- Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists (1994) (7)
- Reaction of trimethylsilyl cyanide with carbodiimides (1975) (7)
- Efficient Asymmetric Syntheses of β‐Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Application to the Syntheses of Novel Isoserines and Taxoids. (1998) (7)
- Application of rhodium-catalyzed cyclohydrocarbonylation to the syntheses of enantiopure homokainoids (2008) (7)
- Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling. (2018) (7)
- Novel rearrangements of chiral 3-oxazolidinylazetidin-2-ones (1992) (7)
- Taxol®: Science and Applications Edited by Matthew Suffness. CRC Press, Boca Raton, FL. 1995. 426 pp. 18.5 × 26 cm. ISBN 0-8493-8382-X. $129.95. (1996) (7)
- Frontiers of Organofluorine Chemistry (2020) (7)
- Medicinal chemistry at a crossroads: challenges and new possibilities. (2009) (7)
- Synthesis of Enatiopure Fluorine-Containing Taxoids and Their Use as Anticancer Agents as well as Probes for Biomedical Problems (1999) (6)
- Preclinical Evaluation of Acylhydrazone SB-AF-1002 as a Novel Broad-Spectrum Antifungal Agent (2020) (6)
- Catalytic Asymmetric Synthesis With Novel Monodentate Phosphorus Ligands (2008) (6)
- Synthesis and evaluation of 6-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine as a PET tracer for nicotinic acetylcholine receptors. (2000) (6)
- Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents (1996) (6)
- Prostate and Colon Cancer Stem Cells as a Target for Anti-Cancer Drug Development (2011) (6)
- Enantioselective Pd-catalyzed tandem allylic alkylation reaction using monodentate phosphoramidite ligands for the formal total synthesis of huperzine A (2014) (6)
- Chemical Evidence for the Existence of pπ-dπ Interaction between the Unsaturated Bond and the Sulfur Atom in Allyl and Vinyl Sulfide Systems (1973) (6)
- Welcome to Future Medicinal Chemistry (2009) (6)
- Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies. (2018) (6)
- Tumor-targeting drug delivery of chemotherapeutic agents (2011) (6)
- Lipopolysaccharide- and paclitaxel (Taxol)-induced tolerance in murine peritoneal macrophages (1999) (5)
- Chapter Five - New Approaches to the Syntheses of Piperidine, Izidine, and Quinazoline Alkaloids by Means of Transition Metal Catalyzed Carbonylations (1999) (5)
- Novel Approaches to the Asymmetric Synthesis of Peptides (1982) (5)
- Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets. (2013) (5)
- Development of new non-peptide GPIIb/IIIa antagonists, NSL-95315 and NSL-95317, isosteres of NSL-95300 (1997) (5)
- Rhodium‐Catalyzed Cyclohydrocarbonylation: Application to the Synthesis of (+)‐Prosopinine and (‐)‐Deoxoprosophylline. (1999) (5)
- 31P NMR STUDIES ON THE MECHANISM OF ASYMMETRIC HYDROGENATION CATALYZED BY RHODIUM(I) COMPLEXES WITH CHIRAL PYRROLIDINODIPHOSPHINE LIGAND. EVIDENCE FOR EXTREMELY REGIOSELECTIVE COMPLEXATION OF PROCHIRAL SUBSTRATES (1979) (5)
- Syntheses, Biological Activity, and Conformational Analysis of Fluorine-Containing Taxoids (1996) (5)
- Intramolecular cycloadditions of α- and β-allylthioalkyl diazoalkanes (1972) (5)
- By Transition Metal Catalysts (2007) (5)
- Syntheses, Biological Activity, and Conformational Analysis of Fluorine‐Containing Taxoids (1997) (5)
- Reaction of trimethylsilyl cyanide with isocyanates (1975) (5)
- Amidocarbonylation, Cyclohydrocarbonylation, and Related Reactions (2007) (5)
- Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation (2019) (4)
- The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes (2021) (4)
- A novel route to 2-carbamoylcycloalkanones by the addition reaction of silyl enol ethers to isocyanates (1974) (4)
- Case studies of fluorine in drug discovery (2019) (4)
- Antifungal Activity of Acylhydrazone Derivatives against Sporothrix spp. (2021) (4)
- Design, synthesis and SAR study of Fluorine-containing 3rd-generation taxoids. (2021) (4)
- Syntheses and Structure—Activity Relationships of New Taxoids (1994) (4)
- New Carbonylations Catalyzed by Transition Metal Complexes (1992) (4)
- Taxol, Taxoids, and Related Taxanes (2014) (4)
- REDUCTION OF CARBONYL COMPOUNDS VIA HYDROSILYLATION. II. ASYMMETRIC REDUCTION N OF KETONES VIA HYDROSILYLATION CATALYZED BY A RHODIUM(I) COMPLEX WITH CHIRAL PHOSPHINE LIGANDS (1977) (4)
- BMS-184476 Bristol-Myers Squibb. (2003) (4)
- Structure-Activity Relationships of New Taxoids Derived from 14β- Hydroxy-10-deacetylbaccatin III. (1994) (4)
- Reactions of silyl enol ethers and ketene silyl ketals with isocyanates (1979) (4)
- Fluoro‐β‐lactams as Useful Building Blocks for the Synthesis of Fluorinated Amino Acids, Dipeptides, and Taxoids (2007) (4)
- New insights into drug resistance in cancer. (2003) (4)
- Asymmetric Synthesis by Means of Chiral Metal Complex Catalysts (1986) (4)
- Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method. (2014) (3)
- β-Lactam Synthon Method: Enantiomerically Pure β-Lactams as Synthetic Intermediates (1994) (3)
- An Improved Synthesis of a Hydroxymethyl Tricyclic Ketone from Cyclohexanone, the Key Processes for the Synthesis of a Highly Potent Antiinflammatory and Cytoprotective Agent. (2014) (3)
- Hydrosilylation of 1-Hexyne Catalyzed by Rhodium and Cobalt-Rhodium Mixed-Metal Complexes. Mechanism of Apparent Trans Addition. (1991) (3)
- NEW SYNTHETIC ROUTE TO N-ACYL α-AMINO ACIDS VIA AMIDOCARBONYLATION BY MEANS OF HOMOGENEOUS BINARY CATALYST SYSTEMS (1985) (3)
- A Novel Approach to the Study of Solution Structures and Dynamic Behavior of Paclitaxel and Docetaxel Using Fluorine‐Containing Analogues as Probes. (1997) (3)
- Pd-catalyzed asymmetric allylic amination with BOP ligands and its applications to the synthesis of fused polycyclic alkaloids (2015) (3)
- Biomedical frontiers of fluorine chemistry : developed from symposia sponsored by the Division of Fluorine Chemistry and the Division of Medicinal Chemistry (1996) (3)
- Asymmetric Hydrosilylation and Hydrocarbonylation (1986) (3)
- cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells (2010) (3)
- KRAS pathway expression changes in pancreatic cancer models by conventional and experimental taxanes. (2019) (3)
- A convenient synthesis of 1,3-dimethyl(5h,7h)imidazo(4,5-dpyrimidine-2,4,6-trithione and its unusual character (1979) (3)
- Interview with Future Medicinal Chemistry's US Senior Editor, Iwao Ojima. Interview by Issac Bruce. (2012) (3)
- Design, synthesis and enzyme inhibitory activities of new trifluoromethyl-containing inhibitors for angiotensin converting enzyme. (1994) (3)
- REDUCTION OF CARBONYL COMPOUNDS VIA HYDROSILYLATION. 4. HIGHLY REGIOSELECTIVE E REDUCTIONS OF α,β-UNSATURATED CARBONYL COMPOUNDS (1983) (3)
- Potent antitumor activity of novel taxoids in anaplastic thyroid cancer (2021) (3)
- 1,2-Cycloaddition of phosphinothioyl and sulphonyl isothiocyanates with carbodi-imides (1970) (3)
- Novel DMAP-catalyzed skeletal rearrangement of 5-exo-(2-hydroxy-ethylene)oxasilacyclopentanes. (2001) (3)
- Azetidines and Bisazetidines. Their Synthesis and Use as the Key Intermediates to Enantiomerically Pure Diamines, Amino Alcohols, and Polyamines. (1992) (3)
- Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents. (2020) (2)
- Syntheses of Norstatine, Its Analogs, and Dipeptide Isosteres by Means of β-Lactam Synthon Method. (1999) (2)
- HYDROSILYLATION OF DIENES, ACETYLENES, AND CARBONYLS CATALYZED BY TRANSITION METAL COMPLEXES (1981) (2)
- Strategic Incorporation of Fluorine for Drug Discovery and Development (2017) (2)
- New Cyclization and Cycloaddition Reactions in Organic Synthesis (2008) (2)
- Rhodium-Catalyzed Pauson–Khand Reaction (2001) (2)
- Extremely Regioselective Intramolecular Silylformylation of Alkynes. (1995) (2)
- Curious effects of fluorine on medicinally active compounds (2021) (2)
- AN EFFECTIVE AND CONVENIENT ROUTE TO 5-(TRIFLUOROMETHYL)-5,6-DIHYDROURACILS AND THEIR THIO DERIVATIVES (1985) (2)
- Selective and Asymmetric Reductions of Carbonyl Compounds Using Hydrosilylation Catalyzed by Rhodium(I) Complexes (1975) (2)
- Recent Progress in The Catalytic Asymmetric Reductions Using Homogeneous Catalysts with Chiral Ligands (1974) (2)
- New and Effective Routes to Fluoro Analogues of Aliphatic and Aromatic Amino Acids. (1990) (2)
- Exploration of Fluorine Chemistry at the Multidisciplinary Interface of Chemistry and Biology (2013) (2)
- Platelet Aggregation Inhibitory Agents (1994) (2)
- Organofluorine chemistry at the biomedical interface : A case study on fluoro-taxoid anticancer agents (2007) (2)
- Synthesis and Structure—Activity Relationships of New Second‐Generation Taxoids. (2000) (2)
- Organometallic Complexes of Rhodium (2004) (2)
- Asymmetric Synthesis of Building‐Blocks for Peptides and Peptidomimetics by Means of the β‐Lactam Synthon Method (1998) (2)
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- EFFECTIVE METHOD FOR THE ASYMMETRIC SYNTHESIS OF BIS-β-LACTAMS BY THE CYCLOADDITION OF AZIDOKETENE TO BENZYLIDENEAMINES BEARING A CHIRAL β-LACTAM BACKBONE (1981) (0)
- Fall 9-24-2013 Prostate Cancer Stem Cell-Targeted Efficacy of a New-Generation Taxoid , SBT-1214 and Novel Polyenolic Zinc-Binding Curcuminoid , CMC 2 . 24 (2019) (0)
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- THE INTRAMOLECULAR PARTICIPATION OF SULFIDE LINKAGE ON THE REACTIVITY OF CARBENES AND DIAZOALKANES PART 2, ALKYLCARBENES AND DIAZOALKANES BEARING ARYLTHIO AND ALLYLTHIO GROUPS ON BETA-CARBON (1975) (0)
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- Novel Amide-Directed Hydrocarbonylation and Double Carbonylation of N-Allylamides. (1989) (0)
- A New Paclitaxel Photoaffinity Analogue with a 3‐(4‐Benzoylphenyl) propanoyl Probe for Characterization of Drug‐Binding Sites on Tubulin and P‐Glycoprotein. (1996) (0)
- A FACILE SYNTHESIS OF N -( p -TOLUENESULFONYL)-2-OXOALKANECARBOXAMIDES BY THE REACTION OF SILYL ENOL ETHERS WITH p -TOLUENESULFONYL ISOCYANATE (1975) (0)
- Homoleptic, Cationic Norbornadiene Complexes via Anionic Ligand Abstraction (2001) (0)
- Cationic Bis(cyclopentadienyl) Complexes by Ligand Substitution (2001) (0)
- Efficient Syntheses of Functionalized Piperidines Through Extremely Regioselective Rh‐Catalyzed Cyclohydrocarbonylation of Amido‐ω,ω′‐dienes. (1998) (0)
- Bioorganic and Medicinal Chemistry of Fluorine. By Jean-Pierre Bégué and Danièle Bonnet-Delpon. (2009) (0)
- [5+2] Vinylcyclopropane–Alkene Cycloaddition (2001) (0)
- N-CARBAMOYL-4-DIPHENYLPHOSPHINO-2-DIPHENYLPHOSPHINOMETHYLPYRROLIDINES (CAPP). EFFICIENT NEW CHIRAL LIGANDS FOR ASYMMETRIC HYDROGENATION (1980) (0)
- Novel and Effective Routes to Optically Pure Amino Acids, Dipeptides, and Their Derivatives via β-Lactams Obtained Through Asymmetric Cycloaddition. (1987) (0)
- Transition Metal‐Catalyzed Carbocyclizations in Organic Synthesis (1996) (0)
- From Pentamethylcyclopentadienyl Anions and Rhodium Halides (2001) (0)
- Trifluoromethyl‐ and Difluoromethyl‐β‐lactams as Useful Building Blocks for the Synthesis of Fluorinated Amino Acids, Dipeptides, and Fluoro‐Taxoids. (2004) (0)
- From Cyclopentadienyl Anions and Rhodium Halides (2001) (0)
- Oxidative Addition of Nickel(0) with Allylic Electrophiles (2001) (0)
- ASYMMETRIC ADDITION OF ALLYLTRIMETHYLSILANE TO (-)-MENTHYL PYRUVATE AND PHENYLGLYOXYLATE (1977) (0)
- Efficient and Practical Asymmetric Synthesis of the Taxol C‐13 Side Chain, N‐Benzoyl‐(2R,3S)‐3‐phenylisoserine, and Its Analogues via Chiral 3‐Hydroxy‐4‐aryl‐β‐lactams Through Chiral Ester Enolate. (1991) (0)
- Overcoming paclitaxel resistance with new fatty acid conjugates of second generation taxoids (2004) (0)
- Monomeric Cycloocta-1,5-diene Complexes (2001) (0)
- HYDROSILYLATION OF α,β-UNSATURATED NITRILES AND ESTERS CATALYZED BY TRIS(TRIPHENYLPHOSPHINE)CHLORORHODIUM (1976) (0)
- [2+2+2] Cyclotrimerization (2001) (0)
- Rhodium–Alkyne Complexes (2001) (0)
- Asymmetric Isomerization of Allylamines: Chapter 3 Addendum—1999 (2005) (0)
- A NOVEL ROUTE TO FORMAMIDES AND THEIR DERIVATIVES, REDUCTION OF ISOCYANATES VIA HYDROSILYLATION CATALYSED BY PALLADIUM (1974) (0)
- Process for the production of aldehydes having a perfluorocarbon group (1981) (0)
- New Carbonylations with Transition Metal Catalysts (1990) (0)
- Synthesis of Pyrrolizidine Alkaloids via Rhodium-Catalyzed Silylformylation and Amidocarbonylation. (1993) (0)
- New and Efficient Catalytic Route to Bicyclo(3.3.0)octa‐1,5‐dien‐3‐ ones. (1997) (0)
- A CONVENIENT SYNTHESIS OF 1,3‐DIMETHYL(5H,7H)IMIDAZO(4,5‐D)PYRIMIDINE‐2,4,6‐TRITHIONE AND ITS UNUSUAL CHARACTER (1979) (0)
- Synthesis of Cationic Chiral Diene Complexes (2001) (0)
- ASYMMETRIC SYNTHESIS OF β‐LACTAMS. I. THE REACTION OF DIMETHYLKETENE SILYL ACETAL WITH (S)‐ALKYLIDENE(1‐ARYLETHYL) AMINES PROMOTED BY TITANIUM TETRACHLORIDE (1980) (0)
- Transition-Metal Complex Catalyzed Polyfluoroalkylation. Part l. Facile Addition of Polyfluoroalkyl Halides to Carbon-Carbon Multiple Bands. Transition-Metal Complex Catalyzed Polyfluoroalkylation. Part 2. Novel and Convenient Route t (1984) (0)
- Silylformylation Catalyzed by Rh and Rh‐Co Mixed Metal Complexes and Its Application to the Synthesis of Pyrrolizidine Alkaloids. (1993) (0)
- Hydroformylation of Fluoro Olefins, RfCH=CH2, Catalyzed by Group VIII Transition-Metal Catalysts. Crucial Factors for Extremely High Regioselectivity. (1988) (0)
- SYNTHESIS OF CHIRAL TRIPEPTIDES BY ASYMMETRIC HYDROGENATION OF DEHYDROTRIPEPTIDES. REMARKABLE EFFECTS OF NITROGEN-PROTECTING GROUPS ON STEREOSELECTIVITY AND REACTIVITY (1983) (0)
- LIST OF POSTERS - RESEARCH DAY - 2006 (2006) (0)
- Cumulapentaene Complex by Ligand Substitution (2001) (0)
- Allyl Complexes by Allylation of Metal Salts (2001) (0)
- Extremely Stereoselective Alkylation of 3‐Siloxy‐β‐lactams and Its Applications to the Asymmetric Syntheses of Novel 2‐Alkylisoserines, Their Dipeptides, and Taxoids. (1998) (0)
- Pd‐Catalyzed Asymmetric Allylic Amination with BOP Ligands and Its Applications to the Synthesis of Fused Polycyclic Alkaloids. (2015) (0)
- TETRAHEDRON REPORT NUMBER 264 RECENT ADVANCES IN CATALYTIC ASYMMETRIC REACTIONS PROMOTED BY TRANSITION METAL COMPLEXES (1989) (0)
- Novel thiocolchicine–vitamin B conjugate for tumor-targeting drug delivery (2020) (0)
- Addition of Allylmagnesium Halides to Nickel(II) Salts (2001) (0)
- η-Cyclohexadienyl Complexes (2001) (0)
- Catalytic Asymmetric Epoxidation of Allylic Alcohols (Addendum 1999) (2001) (0)
- Indenyl Complexes by Ligand Substitution (2001) (0)
- From Arenes and Rhodium(III) Chloride (2001) (0)
- Microwave‐Assisted Diels—Alder Reactions Between Danishefsky′s Diene and Derivatives of Ethyl α‐(Hydroxymethyl)acrylate. Synthetic Approach Toward a Biotinylated Antiinflammatory Monocyclic Cyanoenone. (2013) (0)
- Recent Advances in Catalytic Asymmetric Reactions Promoted by Transition-Metal Complexes (1990) (0)
- Abstract B9: Role of disposition, transport, in vitro efficiency and expression of relevant genes in the effects of novel taxanes on subcutaneous lymphoma in Sprague‐Dawley/Cub rats (2009) (0)
- Novel Synthetic Routes to Organofluorine Compounds of Biological Interest (1987) (0)
- Synthesis and Biological Activity of 14-Hydroxydocetaxel. (1995) (0)
- Syntheses and Structure—Activity Relationships of Novel 3′-Difluoromethyl and 3′-Trifluoromethyl-taxoids. (2009) (0)
- Homoleptic Cationic Cycloocta-1,5-diene Complexes via Anionic Ligand Abstraction (2001) (0)
- [2+2+2] Cycloaddition (2001) (0)
- Murine epidermal fatty acid-binding protein (FABP5), apo form, poly- his tag-mediated crystal packing (2013) (0)
- Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells (2012) (0)
- Report on the 2nd International Symposium on Homogeneous Catalysis (1981) (0)
- Protonation at Iron (2001) (0)
- New Routes to Nitrogen Heterocycles Through Intramolecular Amidocarbonylation of Alkenamides Catalyzed by Rhodium Complexes. (1990) (0)
- Novel T9 loop conformation of filamenting temperature-sensitive mutant Z from Mycobacterium tuberculosis. (2019) (0)
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