Joyce A. Goldstein
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Joyce A. Goldsteinmedical Degrees
Medical
#3099
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Historical Rank
Pharmacology
#368
World Rank
#419
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Joyce A. Goldstein's Degrees
- PhD Pharmacology University of California, San Francisco
- Bachelors Biochemistry University of California, Berkeley
Why Is Joyce A. Goldstein Influential?
(Suggest an Edit or Addition)Joyce A. Goldstein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. (1994) (961)
- Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. (1994) (795)
- Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. (2002) (696)
- Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. (2001) (656)
- The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. (1996) (641)
- Biochemistry and molecular biology of the human CYP2C subfamily. (1994) (517)
- Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. (2001) (493)
- Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. (1994) (368)
- Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. (1997) (357)
- Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. (2001) (353)
- Kidney function influences warfarin responsiveness and hemorrhagic complications. (2009) (271)
- Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. (2001) (247)
- Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. (2001) (241)
- Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448. (1977) (232)
- A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. (1998) (226)
- Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor (2004) (223)
- Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs (1999) (216)
- Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4α (2005) (190)
- Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. (1997) (187)
- Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. (2003) (186)
- Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele. (1999) (179)
- Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. (1998) (174)
- Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups. (2003) (170)
- Amodiaquine Metabolism is Impaired by Common Polymorphisms in CYP2C8: Implications for Malaria Treatment in Africa (2007) (165)
- Expression of CYP1A1 and CYP1A2 genes in human liver. (1993) (164)
- The hydroxylation of omeprazole correlates with S‐mephenytoin metabolism: A population study (1995) (162)
- Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. (2002) (159)
- Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19. (2001) (158)
- Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues (2007) (157)
- Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis. (1991) (155)
- Identification of the human P450 enzymes involved in lansoprazole metabolism. (1996) (155)
- Mechanism of action and structure-activity relationships for the chlorinated dibenzo- p- dioxins and related compounds (1989) (152)
- Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans. (2008) (152)
- Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. (1992) (150)
- Discovery of new potentially defective alleles of human CYP2C9. (2004) (146)
- Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe. (1993) (144)
- Genetic analysis of the S‐mephenytoin polymorphism in a chinese population (1995) (142)
- Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin. (1998) (138)
- Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. (1997) (137)
- Identification and functional characterization of new potentially defective alleles of human CYP2C19. (2002) (137)
- The transcriptional regulation of the human CYP2C genes. (2009) (131)
- A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. (1999) (126)
- Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism. (1996) (124)
- Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues. (1984) (122)
- Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes (2008) (119)
- Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. (1998) (118)
- The Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Cross-Talk with Hepatic Nuclear Factor 4α to Synergistically Activate the Human CYP2C9 Promoter (2005) (116)
- An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. (1998) (114)
- VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans. (2008) (110)
- Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension (2005) (109)
- THE STRUCTURE‐ACTIVITY RELATIONSHIPS OF HALOGENATED BIPHENYLS AS ENZYME INDUCERS (1979) (103)
- A multifamily study on the relationship between CYP2C19 genotype and s-mephenytoin oxidation phenotype. (1995) (101)
- Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. (1996) (95)
- Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans (2003) (95)
- Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. (1991) (95)
- Effects of pentachlorophenol on hepatic drug-metabolizing enzymes and porphyria related to contamination with chlorinated dibenzo-p-dioxins and dibenzofurans. (1977) (94)
- Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. (2005) (93)
- CYP2C44, a New Murine CYP2C That Metabolizes Arachidonic Acid to Unique Stereospecific Products (2004) (93)
- Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist. (1989) (88)
- Experimental hepatic porphyria induced by polychlorinated biphenyls. (1974) (83)
- Functional Characterization of Novel Allelic Variants of CYP2C9 Recently Discovered in Southeast Asians (2005) (81)
- Advances in mechanisms of activation and deactivation of environmental chemicals. (1993) (79)
- Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. (2004) (78)
- In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide. (2002) (75)
- Human CYP2C8 Is Post-Transcriptionally Regulated by MicroRNAs 103 and 107 in Human Liver (2012) (75)
- Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions. (1995) (75)
- Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8,-tetrachlorodibenzofuran in chicks. II. Effects on drug metabolism and porphyrin accumulation. (1976) (75)
- Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity (*) (1996) (74)
- Recombinant CYP3A4*17 Is Defective in Metabolizing the Hypertensive Drug Nifedipine, and the CYP3A4*17 Allele May Occur on the Same Chromosome as CYP3A5*3, Representing a New Putative Defective CYP3A Haplotype (2005) (74)
- Hepatic porphyria induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse. (1973) (72)
- The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice. (1991) (72)
- Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis. (2011) (71)
- Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d. (1989) (71)
- Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes (2003) (70)
- Enhanced biliary excretion of thyroxine glucuronide in rats pretreated with benzpyrene. (1968) (69)
- 2,3,7,8-Tetrachlorodibenzofuran in a commercially available 99% pure polychlorinated biphenyl isomer identified as the inducer of hepatic cytochrome P-448 and aryl hydrocarbon hydroxylase in the rat. (1978) (69)
- Effects of a polybrominated biphenyl mixture in the rat and mouse. I. Six-month exposure. (1983) (67)
- Mouse Liver CYP2C39 Is a Novel Retinoic Acid 4-Hydroxylase (2004) (67)
- Influence of CYP2C9 and VKORC1 on warfarin response during initiation of therapy. (2009) (66)
- Purification and characterization of a second form of hepatic cytochrome P-448 from rats treated with a pure polychlorinated biphenyl isomer. (1982) (66)
- Increases in cytochrome P-450 mediated 17 beta-estradiol 2-hydroxylase activity in rat liver microsomes after both acute administration and subchronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a two-stage hepatocarcinogenesis model. (1988) (65)
- Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction. (1996) (65)
- Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. (1993) (64)
- Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products. (2001) (63)
- Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. (1998) (62)
- A comparative study of two polychlorinated biphenyl mixtures (Aroclors 1242 and 1016) containing 42% chlorine on induction of hepatic porphyria and drug metabolizing enzymes. (1975) (58)
- Torsemide metabolism by CYP2C9 variants and other human CYP2C subfamily enzymes. (2000) (58)
- Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C9*1 heterozygotes (2002) (58)
- Med25 Is Required for RNA Polymerase II Recruitment to Specific Promoters, Thus Regulating Xenobiotic and Lipid Metabolism in Human Liver (2010) (58)
- Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen. (1998) (57)
- Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2. (1991) (57)
- Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450 2C subfamily (1991) (56)
- Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor. (1991) (56)
- Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. (1989) (55)
- Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. (1987) (53)
- Genetic polymorphism of S-mephenytoin 4'-hydroxylation in African-Americans. (1996) (53)
- Assessment of the contribution of chlorinated dibenzo-p-dioxins and dibenzofurans to hexachlorobenzene-induced toxicity, porphyria, changes in mixed function oxygenases, and histopathological changes. (1978) (52)
- The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29. (2004) (52)
- P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. (2012) (51)
- Effects of purified and technical piperonyl butoxide on drug-metabolizing enzymes and ultrastructure of rat liver. (1973) (50)
- Immunochemical evidence for two 3-methylcholanthrene-inducible forms of cytochrome P-448 in rat liver microsomes using a double-antibody radioimmunoassay procedure. (1983) (49)
- The chronic toxicity of technical and analytical pentachlorophenol in cattle. I. Clinicopathology. (1980) (48)
- Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor (2006) (47)
- Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis. (2012) (46)
- Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. (1999) (46)
- Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1. (1983) (46)
- Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1982) (45)
- Hepatocyte Nuclear Factor 4α Regulates Rifampicin-Mediated Induction of CYP2C Genes in Primary Cultures of Human Hepatocytes (2010) (44)
- Analysis of the CYP2C19 polymorphism in a North-eastern Thai population. (2002) (44)
- The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice. (1988) (44)
- Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats. (1987) (43)
- Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure (2011) (42)
- Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9. (2001) (41)
- Evaluation of potential losartan‐phenytoin drug interactions in healthy volunteers * (2002) (40)
- Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice. (1986) (39)
- Nuclear Receptor Coactivator 6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4α (2008) (39)
- Losartan and E3174 Pharmacokinetics in Cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 Individuals (2003) (39)
- Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human. (1993) (38)
- Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles. (2000) (37)
- Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450 (2006) (35)
- CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population. (1996) (35)
- CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract. (2000) (34)
- Genetic Polymorphisms in Human Drug Metabolic Enzymes (1997) (31)
- Structure-activity relationships of chlorinated benzenes as inducers of different forms of cytochrome P-450 in rat liver. (1982) (31)
- Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. [Erratum to document cited in CA114(15):137136r] (1993) (31)
- Pharmacogenetics in clinical pharmacology and toxicology. (1995) (30)
- RBCK1, an E3 Ubiquitin Ligase, Interacts with and Ubiquinates the Human Pregnane X Receptor (2013) (30)
- A single amino acid mutation (Ser180----Cys) determines the polymorphism in cytochrome P450g (P4502C13) by altering protein stability. (1992) (29)
- CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases (2009) (29)
- A comparison of a commercial polybrominated biphenyl mixture, 2,4,5,2',4',5'-hexabromobiphenyl and 2,3,6,7-tetrabromonaphthalene as inducers of liver microsomal drug-metabolizing enzymes. (1979) (28)
- Associations of ABCB1 3435C>T and IL-10-1082G>A Polymorphisms With Long-Term Sirolimus Dose Requirements in Renal Transplant Patients (2011) (28)
- Covalent binding to DNA and mutagenicity of 2,4-diaminotoluene metabolites produced by isolated hepatocytes and 9000 g supernatant from Fischer 344 rats. (1987) (28)
- Identification of Human CYP2C8 as a Retinoid-Related Orphan Nuclear Receptor Target Gene (2009) (27)
- Differences in the Incidence of the CYP 2 C 19 Polymorphism Affecting the S-Mephenytoin Phenotype in Chinese Han and Bai Populations and Identification of a New Rare CYP 2 C 19 Mutant Allele 1 (1997) (27)
- Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene. (1985) (27)
- Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities. (2012) (25)
- Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity. (1996) (25)
- Epigenetic Modification of Histone 3 Lysine 27 (2014) (25)
- The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system (2007) (25)
- Characterization of a cDNA for rat P-450g, a highly polymorphic, male-specific cytochrome in the P-450IIC subfamily. (1989) (25)
- Erectile function and naltrexone. (1986) (23)
- Mechanism of induction of hepatic drug metabolizing enzymes: recent advances (1984) (22)
- Reversal of in vitro hepatic insulin resistance in chronic pancreatitis by pancreatic polypeptide in the rat. (1989) (22)
- Genetic polymorphisms in human drug metabolic enzymes. (1997) (21)
- A reciprocal relationship between the induction of -aminolevulinic acid synthetase and drug metabolism produced by m-dichlorobenzene. (1971) (20)
- CYP2C9 Genetic Polymorphisms and Warfarin (2004) (18)
- CYP2C8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor α in Human Liver (2016) (18)
- Involvement of cytochrome P-450c in alpha-naphthoflavone metabolism by rat liver microsomes. (1990) (18)
- Cimetidine, ranitidine, and Epstein-Barr virus infection. (1986) (17)
- Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450. (1983) (16)
- Activator Protein-1 Regulation of Murine Aldehyde Dehydrogenase 1a1 (2012) (15)
- A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression System (2007) (15)
- The Nuclear Receptors Constitutive Active/Androstane Receptor and Pregnane X Receptor Activate the Cyp2c55 Gene in Mouse Liver (2010) (14)
- Detection of Human CYP 2 C 8 , CYP 2 C 9 , and CYP 2 J 2 in Cardiovascular Tissues (2006) (14)
- Metabolism of 2-acetylaminofluorene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450. (1984) (14)
- Dose response for induction of two cytochrome P-450 isozymes and their mRNAs by 3,4,5,3'4'5'-hexachlorobiphenyl indicating coordinate regulation in rat liver. (1985) (14)
- Induction of cytochrome P-450c in hematopoietic cells of fetal liver. (1986) (13)
- Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. (1987) (12)
- Effect of o-benzyl-p-chlorophenol on drug-metabolizing enzymes in rats. (1986) (12)
- Associations of ABCB1 and IL-10 Genetic Polymorphisms With Sirolimus-Induced Dyslipidemia in Renal Transplant Recipients (2012) (11)
- The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping (2014) (11)
- Regulation of Human CYP2C9 Expression by Electrophilic Stress Involves Activator Protein 1 Activation and DNA Looping (2014) (10)
- Reduced Methylprednisolone Clearance Causing Prolonged Pharmacodynamics in a Healthy Subject Was Not Associated With CYP3A5*3 Allele or a Change in Diet Composition (2006) (10)
- The effects of TCDD on receptors for epidermal growth factor, glucocorticoid, and estrogen in Ah-responsive and -nonresponsive congenic mice and the effects of TCDD on estradiol metabolism in a liver tumor promotion model in female rats. (1990) (9)
- NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes. (2011) (9)
- Marked differences in the inductive effects of two symmetrical hexachlorobiphenyls and the corresponding unsymmetrical isomer on hepatic monooxygenases. (1981) (8)
- Identification of New Human CYP 2 C 19 Alleles ( CYP 2 C 19 * 6 and CYP 2 C 19 * 2 B ) in a Caucasian Poor Metabolizer of Mephenytoin 1 (1998) (8)
- Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. (1989) (8)
- Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes. (1990) (8)
- Effects of dose and route of exposure on dioxin disposition (1992) (7)
- CYP2C9 polymorphisms and CYP2C9*2 genotyping primers. (2002) (7)
- Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression. (2014) (6)
- Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and renal prostaglandin synthetase. (1981) (6)
- A Single Amino Acid Mutation ( SerlS 0-- ? ) Cys ) Determines the Polymorphism in Cytochrome P 450 g ( P 4502 C 13 ) by Altering Protein Stability * (2001) (5)
- Multiple forms of solubilized and partially resolved cytochrome P-450 from rats induced by 2,3,5,2',3',5'- and 3,4,5,3',4',5'-hexachlorobiphenyls. (1981) (5)
- Faculty Opinions recommendation of Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. (2006) (4)
- Cimetidine and mononucleosis. (1983) (4)
- Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat. (1986) (4)
- Effects of 2,3,7,8-tetrachlorodibenzo-dioxin (TCDD) on estradiol metabolism and enzyme-altered foci in a two stage hepatocarcinogenesis model in rats (1989) (3)
- Humans exposed to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) exhibit increased SCE frequencies in lymphocytes when incubated with α-naphthoflavone: Involvement of metabolic activation by P-450 isozymes (1989) (3)
- Identification of Human CYP2C8 as a Retinoic Acid Receptor-Related Orphan Receptor (ROR) Target Gene 1 (2009) (2)
- Polymerization of 4‐vinylpyridine with acylating agents (1972) (2)
- Effect of hexachlorobenzene on the specific binding of 2,3,7,8,-TCDD to the hepatic receptor (1986) (2)
- CYP 2 C 8 Is a Novel Target of Peroxisome Proliferator-Activated Receptor a in Human Liver s (2015) (1)
- The retinoic acid receptor‐related orphan receptor (ROR) regulates human CYP2C8 (1)
- PGC‐1α regulates both the constitutive and drug‐inducible expression of human CYP2C9 (2006) (1)
- The Nuclear Receptors CAR and PXR Activate the Cyp 2 c 55 Gene in Mouse Liver (2010) (1)
- Microsoft Word-91204411-file00 (2010) (0)
- DMD048728 398..405 (2013) (0)
- Faculty Opinions recommendation of Effects of CYP2C9*1/*13 on the pharmacokinetics and pharmacodynamics of meloxicam. (2011) (0)
- Stephen Metabolism in Human Liver Regulating Xenobiotic and Lipid Recruitment to Specific Promoters , Thus Med 25 Is Required for RNA Polymerase II (2011) (0)
- Identification and functional studies of human CYP26A1 Single Nucleotide Polymorphisms (SNPs) in racially diverse populations (2006) (0)
- PKC phosphorylation of Med25 is critical for Mediator assembly: Implications for HNF4α signaling in drug metabolism (2013) (0)
- Faculty Opinions recommendation of Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. (2008) (0)
- Faculty Opinions recommendation of Relative impact of genotype and enzyme induction on the metabolic capacity of CYP2C9 in healthy volunteers. (2010) (0)
- Cloning, expression and characterization of three new murine CYP2Cs involved in fatty acid metabolism (2003) (0)
- The constitutive androstane receptor mediates phenytoin induction of cyp2c37 (2006) (0)
- Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily. (1993) (0)
- metabolism in a recombinant cDNA expression system (2006) (0)
- Ubiquitin Ligase , Interacts with and Ubiquinates the Human Pregnane X Receptor ( hPXR ) (2012) (0)
- Epigenetic Modification of Histone 3 Lysine 27 MEDIATORSUBUNITMED25ISREQUIREDFORTHEDISSOCIATIONOFPOLYCOMB REPRESSIVECOMPLEX2FROMTHEPROMOTEROFCYTOCHROMEP4502C9 (2015) (0)
- Interethnic Differences in Drug Metabolism and Pharmacogenetics (1995) (0)
- Repression of cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl (HCB), 3-methylcholanthrene (3-MC) and phenobarbital (PB) in livers from male rats (1986) (0)
- Genetic Polymorphisms in Human Drug Metabolic Enzymes 1 (2005) (0)
- Studies on the Role of the Ah Receptor in Hexachlorobenzene‐Induced Porphyria (1987) (0)
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