John Angus Hickman
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Biology
John Angus Hickman's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biochemistry Stanford University
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(Suggest an Edit or Addition)John Angus Hickman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. (1993) (1209)
- Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1 (2007) (1132)
- The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models (2016) (760)
- The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. (1994) (621)
- Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis (1999) (533)
- Apoptosis induced by anticancer drugs (1992) (527)
- BH3-Only Proteins and BH3 Mimetics Induce Autophagy by Competitively Disrupting the Interaction between Beclin 1 and Bcl-2/Bcl-XL (2007) (442)
- Drug-target interactions: only the first step in the commitment to a programmed cell death? (1991) (436)
- Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. (1987) (393)
- Apoptosis and cancer chemotherapy. (1994) (366)
- Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. (1995) (326)
- Limits to Personalized Cancer Medicine. (2016) (316)
- Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. (1996) (299)
- Three‐dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo (2014) (299)
- Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. (1996) (286)
- bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. (1993) (262)
- Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation (1997) (235)
- Apoptosis and cancer chemotherapy (2000) (225)
- Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells (2008) (225)
- Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons (2008) (221)
- Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. (1997) (203)
- Characterization of radiation-induced apoptosis in the small intestine and its biological implications. (1994) (198)
- Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent. (1984) (188)
- Apoptosis and chemotherapy resistance. (1996) (174)
- Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members (2009) (155)
- Damage‐induced Bax N‐terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate (2001) (142)
- Evidence of reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas. (1996) (141)
- Bid, a Widely Expressed Proapoptotic Protein of the Bcl-2 Family, Displays Lipid Transfer Activity (2001) (132)
- The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. (1998) (129)
- Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers (1998) (123)
- Cell Cycle-Dependent Induction of Autophagy, Mitophagy and Reticulophagy (2007) (118)
- Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo (1999) (111)
- Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors. (2000) (103)
- Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest. (1998) (101)
- Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. (1999) (99)
- Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL (2003) (97)
- Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. (2004) (95)
- Only a subset of Met-activated pathways are required to sustain oncogene addiction. (2009) (94)
- Apoptosis and tumourigenesis. (2002) (94)
- Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices (2015) (93)
- Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak (2001) (88)
- Blockade of αvβ3 and αvβ5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells (2006) (85)
- Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis (1999) (85)
- Post-translational Modification of Bid Has Differential Effects on Its Susceptibility to Cleavage by Caspase 8 or Caspase 3* (2003) (78)
- Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine (2000) (77)
- S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab (2013) (72)
- DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one. (1984) (69)
- Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis. (1995) (68)
- Shooting at survivors: Bcl-2 family members as drug targets for cancer. (2004) (68)
- Synthesis and biological evaluation of a series of flavones designed as inhibitors of protein tyrosine kinases. (1992) (67)
- N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death (2012) (66)
- S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth (2018) (65)
- Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis. (2001) (64)
- Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells. (1995) (61)
- N-methylformamide: antitumour activity and metabolism in mice. (1982) (61)
- Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells. (1997) (60)
- Changes of mitochondrial mass in the hemopoietic stem cell line FDCP-mix after treatment with etoposide: a correlative study by multiparameter flow cytometry and confocal and electron microscopy. (1995) (60)
- Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors. (2001) (59)
- Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology. (1997) (58)
- Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety. (2003) (57)
- MDM2 mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells. (2001) (56)
- Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells. (2006) (53)
- Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin. (2003) (52)
- Experimental antitumor activity against murine tumor model systems of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one (mitozolomide), a novel broad-spectrum agent. (1985) (51)
- MCF‐7 human mammary adenocarcinoma cell death in vitro in response to hormone‐withdrawal and dna damage (1995) (50)
- Investigation of the effects of heat shock and agents which induce a heat shock response on the induction of differentiation of HL-60 cells. (1988) (49)
- NSO myeloma cell death: Influence of bcl‐2 overexpression (1996) (49)
- Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. (2008) (48)
- Cell Surface Membranes as a Chemotherapeutic Target (1985) (46)
- Exposure to Hypoxia Rapidly Induces Mitochondrial Channel Activity within a Living Synapse* (2005) (46)
- Synthesis and biological activities of isogranulatimide analogues. (2007) (46)
- Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism. (2005) (45)
- Effects of the antitumor agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one on the DNA of mouse L1210 cells. (1984) (45)
- Alkylation of Guanine in DNA by S23906-1, a Novel Potent Antitumor Compound Derived from the Plant Alkaloid Acronycine† (2002) (44)
- Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues. (2003) (43)
- Perturbation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology (1997) (42)
- Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment (2006) (41)
- Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-xL (2010) (41)
- Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members. (1998) (41)
- Elevation of leukemic cell intracellular calcium by the ether lipid SRI 62-834. (1990) (40)
- Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients (2007) (37)
- Investigation of the mechanism of action of antitumour dimethyltriazenes (1978) (37)
- Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction (2009) (36)
- The generation of potentially toxic, reactive iminium ions from the oxidative metabolism of xenobiotic N-alkyl compounds. (1985) (36)
- Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1. (2002) (35)
- Correlation between the molecular weight and potency of polar compounds which induce the differentiation of HL-60 human promyelocytic leukemia cells. (1987) (35)
- Structural studies on bioactive compounds. 4. A structure-antitumor activity study on analogues of N-methylformamide. (1986) (34)
- Acronycine derivatives as promising antitumor agents. (2002) (34)
- Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs (2007) (32)
- Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues. (2009) (32)
- The effects of nitrogen mustard (HN2) on activities of the plasma membrane of PC6A mouse plasmacytoma cells. (1982) (31)
- Survival signals within the tumour microenvironment suppress drug-induced apoptosis: lessons learned from B lymphomas. (1999) (31)
- Induction of apoptosis by anti-cancer drugs with disparate modes of action: kinetics of cell death and changes in c-myc expression. (1995) (31)
- N-Methylformamide (NSC 3051): a potential candidate for combination chemotherapy. (1985) (30)
- Changes in c-myc expression and the kinetics of dexamethasone-induced programmed cell death (apoptosis) in human lymphoid leukaemia cells. (1994) (30)
- The role of isocyanates in the toxicity of antitumour haloalkylnitrosoureas. (1982) (30)
- An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells. (2010) (29)
- How to kill cancer cells: membranes and cell signaling as targets in cancer chemotherapy. (1990) (28)
- Mechanisms of cytotoxicity caused by antitumour drugs. (1992) (28)
- Studies of the mode of action of antitumour triazenes and triazines-II. Investigation of the selective toxicity of 1-aryl-3,3-dimethyltriazenes. (1981) (27)
- α-hydroxylated derivatives of antitumour dimethyltriazenes (1978) (27)
- Differentiation: a suitable strategy for cancer chemotherapy? (1993) (27)
- Selective inhibition of topoisomerase II by ICRF-193 does not support a role for topoisomerase II activity in the fragmentation of chromatin during apoptosis of human leukemia cells. (1996) (26)
- The formation and metabolism of N-hydroxymethyl compounds--III. The metabolic conversion of N-methyl and N,N,-dimethylbenzamides to N-hydroxymethyl compounds. (1983) (26)
- Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors. (2008) (26)
- Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity. (1998) (26)
- Programmed Cell Death in Tumours and Tissues (1991) (25)
- The chemosensitivity of a new experimental model--the M5076 reticulum cell sarcoma. (1984) (25)
- Membrane targets in cancer chemotherapy (1984) (25)
- Oxidative metabolism of some N-methyl containing xenobiotics can lead to stable progenitors of formaldehyde. (1979) (25)
- Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors. (2004) (25)
- Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project (2017) (24)
- Toxin-induced increase in survival factor receptors: modulation of the threshold for apoptosis. (1997) (23)
- Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives. (2003) (23)
- The Role of p 53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p 53-deficient Mice 1 (2006) (22)
- Nucleolar segregation during apoptosis of haemopoietic stem cell line FDCP-Mix1 (1999) (22)
- The formation and metabolism of N-hydroxymethyl compounds--IV. Cytotoxicity and antitumour activity of N-hydroxymethylformamide, a putative metabolite of N-methylformamide (NSC 3051). (1983) (22)
- Nuclear pore clustering is a consistent feature of apoptosis in vitro. (1996) (22)
- Oddball p53 in testicular tumors (1996) (22)
- Studies of the mode of action of antitumor triazenes and triazines. 6. 1-Aryl-3-(hydroxymethyl)-3-methyltriazenes: synthesis, chemistry, and antitumor properties. (1984) (22)
- Disruption of focal adhesions mediates detachment during neuronal apoptosis (2001) (22)
- Apoptosis and cytotoxins. (1997) (22)
- Heat shock protein expression in testis and bladder cancer cell lines exhibiting differential sensitivity to heat. (1995) (21)
- Inhibition of human erythrocyte inositol lipid metabolism by adriamycin. (1987) (21)
- Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine. (2002) (20)
- Alkylformamides as inducers of tumour cell differentiation--a mini-review. (1987) (19)
- Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1 (2019) (18)
- ANTITUMOUR IMIDAZOTETRAZINES. 1. SYNTHESIS AND CHEMISTRY OF 8-CARBAMOYL-3-(2-CHLOROETHYL)IMIDAZO(5,1-D)-1,2,3,5-TETRAZIN-4(3H)-ONE, A NOVEL BROAD-SPECTRUM ANTITUMOR AGENT (1984) (18)
- Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist. (2003) (18)
- The formation and metabolism of N-hydroxymethyl compounds--I. The oxidative N-demethylation of N-dimethyl derivatives of arylamines, aryltriazenes, arylformamidines and arylureas including the herbicide monuron. (1983) (17)
- Synthesis and biological activities of indolocarbazoles bearing amino acid residues. (2001) (16)
- Investigations of mechanisms of drug-induced changes in gene expression: N-methylformamide-induced changes in synthesis of the M(r) 72,000 constitutive heat shock protein during commitment of HL-60 cells to granulocyte differentiation. (1993) (16)
- Protection against the effects of the antitumour agent CB 1954 by certain imidazoles and related compounds. (1975) (16)
- Cytoskeletal proteolysis during calcium-induced morphological transitions of human erythrocytes. (1992) (16)
- Studies of the mode of action of antitumour triazenes and triazines--IV. The metabolism of 1-(4-acetylphenyl)-3,3-dimethyltriazene. (1982) (15)
- Effects of N-methylformamide on the growth, cell cycle, and glutathione status of murine TLX5 lymphoma cells. (1988) (15)
- Role of the extracellular matrix on the growth and differentiated phenotype of murine colonic adenocarcinoma cells in vitro (1991) (15)
- The Cell Membrane and Cell Signals as Targets in Cancer Chemotherapy AACR, EORTC, and BACR Special Conference in Cancer Research (1990) (14)
- The effects of adriamycin on intracellular calcium concentrations of L1210 murine leukemia cells. (1987) (14)
- Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-xL/Bcl-w antagonist ABT-737 (2010) (14)
- Farnesyltransferase Inhibitors in Cancer Therapy (2001) (13)
- Effects of the antitumor drug Adriamycin on human red blood cell discocyte-echinocyte transitions. (1985) (13)
- Selective inhibition by bis(2-chloroethyl)methylamine (nitrogen mustard) of the Na+/K+/Cl- cotransporter of murine L1210 leukemia cells. (1988) (13)
- Studies on the toxicity of the antitumour agent N-methylformamide in mice. (1985) (12)
- Erratum: Only a subset of met-activated pathways are required to sustain oncogene addiction (Science Signaling (2009) 2 (er11) (2009) (11)
- Indolizines. Part V. The synthesis of 3-amino- and 3-acetamido-indolizines and their precursors, the 3-azo-, -nitroso-, -nitro-, and -acetyl-indolizines (1972) (11)
- Molecular screening to select therapy for advanced cancer? (2019) (11)
- Molecular screening to select therapy for advanced cancer? (2019) (11)
- Predictive validity in drug discovery: what it is, why it matters and how to improve it (2022) (11)
- Cell cycle specific induction of HL-60 cell differentiation and apoptosis by mycophenolic acid (1997) (10)
- The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): genetic differences between BALB/c and DBA/2 mice. (2000) (10)
- Investigations of the action of the antitumour drug adriamycin on tumour cell membrane functions--I. (1985) (10)
- Characterisation of a Na+/K+/Cl- cotransporter in alkylating agent-sensitive L1210 murine leukemia cells. (1988) (10)
- Interaction of the antibiotic adriamycin with the plasma membrane. (1985) (10)
- Apoptosis and Cancer Chemotherapy (1996) (9)
- Limits to Precision Cancer Medicine. (2017) (8)
- Parallel liquid synthesis of N,N'-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors. (2003) (8)
- Changes in HSC70 and c-myc in HL-60 [HL60] cells engaging differentiation or apoptosis (1993) (8)
- Investigations of the relationship between cell proliferation and differentiation of HL-60 cells induced to differentiate by N-methylformamide. (1988) (7)
- DNA inclusions within autolytic cytoplasmic vacuoles of hemopoietic stem cell line FDCP-Mix. (1996) (7)
- Bcl2L12, a new BH2 BH3 containing protein, substrate for GSK3beta, mediates UV induced apoptosis (2006) (7)
- Dimers from dechlorinated rebeccamycin: synthesis, interaction with DNA, and antiproliferative activities. (2002) (7)
- Studies on the protection by imidazoles against the cytotoxicity of the antitumour alkylating agents melphalan and CB 1954. (1976) (7)
- Antagonistes de Bcl-2, thérapies anticancéreuses alternatives (2005) (7)
- The metabolism of a stable N-hydroxymethyl derivative of a N-methylamide. (1983) (7)
- The effect of phorbol esters on human erythrocyte morphological discocyte-echinocyte transitions. (1987) (7)
- [The Bcl-2 family of proteins as drug targets]. (2005) (6)
- Control of apoptosis in breast epithelium (1997) (6)
- The influence of type I collagen on the growth and differentiation of the human colonic adenocarcinoma cell line HT-29 in vitro. (1992) (6)
- Indolizines. Part VI. Ring-opening reactions of 3-amino- and 3-nitrosox-indolizines (1972) (5)
- Analogues of antifungal tjipanazoles from rebeccamycin. (2004) (5)
- Controlled exploration of structural databases: the case of farnesyl transferase inhibitors. (2009) (5)
- Membrane and Signal Transduction Targets (1992) (5)
- Different cell thresholds for commitment to death: a link between carcinogenesis and drug resistance. (1998) (5)
- Doxorubicin interactions at the membrane: evidence for a biphasic modulation of inositol lipid metabolism. (1991) (5)
- The European Union and personalised cancer medicine. (2021) (4)
- Drug Resistance In The Treatment of Cancer: Genes that modulate apoptosis: major determinants of drug resistance (1998) (4)
- Membrane targets in cancer chemotherapy. (1988) (4)
- Mode of action of the anti tumor drug nitrogen mustard mustine (1979) (4)
- Structure activity relationships in a series of anti-neoplastic dinitrophenyl aziridines--protein binding studies. (1974) (4)
- Programmed cell death and the mammary gland--the involvement of the Bcl-2 family members in the control of epithelial apoptosis. (1996) (3)
- Genetic Determinants of Cell Death and Toxicity (1999) (3)
- Apoptosis as a therapeutic target (1996) (3)
- STUDIES ON THE MODE OF ACTION OF THE ANTITUMOUR DRUG NITROGEN MUSTARD (MUSTINE) (1979) (3)
- Calcium-induced heterogeneous changes in membrane potential detected by flow cytofluorimetry. (1984) (3)
- Apoptosis: its relevance to carcinogenesis and anti-tumour drug sensitivity (1999) (3)
- STUDIES OF THE MODE OF ACTION OF ANTITUMOR TRIAZENES AND TRIAZINES. 6. 1-ARYL-3-(HYDROXYMETHYL)-3-METHYLTRIAZENES: SYNTHESIS, CHEMISTRY, AND ANTITUMOR PROPERTIES (1984) (2)
- Small Molecule Therapeutics S 49076 Is a Novel Kinase Inhibitor of MET , AXL , and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab (2013) (2)
- The formation and metabolism of N-hydroxymethyl compounds--IX. N-(acetoxymethyl)-4-chlorobenzamide: an electrophile but not a mutagen in Salmonella typhimurium. (1986) (2)
- Investigations of Mechanisms of Drug-induced Changes in Gene Expression: W-Methylformamide-induced Changes in Synthesis of the Mr 72,000 Constitutive Heat Shock Protein during Commitment of HL-60 (1993) (2)
- Changes and challenges--the world post-Gleevec (Glivec). (2002) (2)
- Inhibition of the chemotactic peptide-induced elevation of intracellular calcium in differentiated human leukemic (HL-60) cells by the phorbol ester phorbol 12-myristate 13-acetate. (1988) (2)
- Estimation by FACS of the delivery of liposome encapsulated macromolecules into myeloid cells (1990) (1)
- restoration of p53 nuclear localization and apoptosis in neuroblastomas by antisense MDM2 (1999) (1)
- Ant¡tumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl- imidazo[5,l-on-l,2,3,5-tetrazin-4(37/)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine1 (2006) (1)
- Synthesis of N,N′‐Disubstituted 3‐Aminobenzo[c] and [d]Azepin‐2‐ones as Potent and Specific Farnesyl Transferase Inhibitors. (2004) (1)
- The role of proteolysis and phosphorylation of cytoskeletal proteins in human erythrocytes discocyte-echinocyte transition and the effect of adriamycin (1987) (1)
- Membrane Targets in Cancer Chemotherapy A Report of a One Day Symposium of the EORTC-PAM Group Meeting (1988) (1)
- A comparative study of the anti-tumour activity of N-methylformamide and related compounds. (1981) (1)
- The control of apoptosis through cell-stromal interactions (1998) (1)
- Unwarranted pessimism in cancer chemotherapy. (1989) (1)
- The metabolism of the anti-tumour agent 1(1-aziridinyl)- 2,4-dinitrobenzene (CB 1837). (1975) (1)
- 7 Apoptosis: Its role in drug sensitivity and resistance (1995) (1)
- Damage-induced Bax N-terminal change and translocation to mitochondria occur regardless of cell fate (2001) (1)
- Abstract A238: S 49076, a novel, potent, MET/FGFR/AXL kinase inhibitor with wide antitumor activity. (2011) (1)
- Protocols and characterization data for 2 D , 3 D , and slice-based tumor models from the PREDECT project de Hoogt (1)
- New derivatives of 9-amino-podophyllotoxin, their process for the preparation and pharmaceutical compositions containing them (2003) (0)
- Benzo [b] pyrano [3,2-h] acridine-7-one-cinnamic acid derivatives, process for their preparation and to pharmaceutical samrnensætninger containing them. (2005) (0)
- In vitro biotransformation of carbinolamine metabolites of cytotoxic dimethyltriazenes [proceedings]. (1979) (0)
- 51 Investigations of the mechanism of action of antitumour triazenes (1978) (0)
- Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound (2019) (0)
- In vitro selective cytotoxicities of rebeccamycin analogues toward various tumor cell lines: influence of the substituents (2005) (0)
- Dihidroindolona new derivatives, process for their preparation and pharmaceutical compositions containing them (2010) (0)
- The influence of the extracellular matrix on the growth and differentiation of ht 29 human colon adenocarcinoma cells (1990) (0)
- [New approaches in experimental cancerology: in search of therapeutic models]. (2001) (0)
- Comparative study of propranolol and dicyclohexylamine protection of alpha-receptor blockade. (1977) (0)
- Abstract 5040: Perfusion air culture of tissue slices: A new method to cultivate tumor tissue with minimal culture-dependent tissue stress (2018) (0)
- New derivatives of indenoindolones, their process for the preparation and pharmaceutical compositions containing them (2001) (0)
- Investigation of the role of isocyanates in the cytotoxicity of haloalkylnitrosoureas to the tlx5 lymphoma. Abstr. (1981) (0)
- SUBSTITUTED i1,4öBENZODIOXINi2,3-EöISOINDOL DERIVATIVES, METHOD FOR PRODUCING AND YOU pharmaceutical compositions containing (2003) (0)
- New pyrido-pyrido-pyrrolo [3,2-g] pyrrolo [3,4-e] -indol-pyrido and pyrrolo [2,3-a] pyrrolo [3,4-c] carbazole, PROCESS FOR THEIR PREPARATION and pharmaceutical compositions containing them (2001) (0)
- be 1-2 Modulation of Apoptosis Induced by Anticancer Drugs : Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways 1 (2006) (0)
- Suppression of tumourigenesis by cell death (2006) (0)
- Structure of human Bcl-2 in complex with ABT-263 (2019) (0)
- Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity (2012) (0)
- Studies on the modes of action of dicyclohexylamine and related amines with a potentiating effect on noradrenaline responses in the rat vas deferens. (1979) (0)
- New derivatives of [1,4] benzodioxino [2,3-a] isoindole substituted, their process for the preparation and pharmaceutical compositions containing them (2002) (0)
- Cytotoxicity and anti-tumour activity of N-hydroxymethylformamide, a putative metabolite of N-methylformamide (1982) (0)
- Differentiation during Commitment of HL-60 Cells to Granulocyte 72 , 000 Constitutive Heat Shock Proteinr M Synthesis of the-Methylformamide-induced Changes in N Gene Expression : Investigations of Mechanisms of Drug-induced Changes in Updated (2006) (0)
- Reason for beclin protein interacting with anti-apoptotic members of the family of protein bcl-2 and uses (2005) (0)
- 290 POSTER The cytotoxic activity of the monofunctionaol alkylator S23906 is mediated by generation of DNA double strand breaks that are repaired by homologous recombination in mammalian cells (2006) (0)
- "New derivatives indolizine, their process for the preparation and pharmaceutical compositions containing them" (2012) (0)
- Studies of the mechanism of action of anitumour compounds (1989) (0)
- Suppression of drug-induced apoptosis by B lymphoma micro-environmental survival signals (2000) (0)
- SUBSTITUTED i1,4öBENZODIOXINi2,3-EöISOINDOL DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS (2003) (0)
- Apoptosis in cancer and cancer treatment (1995) (0)
- Corrigendum to “Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity” [Toxicol. Lett. 102–103C (1998) 19–27] (2012) (0)
- Bcl-X-L induces Drp1-dependent synapse formation in cultured hippocampal neurons (2019) (0)
- New derivatives of hydroxamic acid, their process for the preparation and pharmaceutical compositions containing them (1998) (0)
- Enhanced Phosphoproteomic Profiling Workflow For Growth Factor Signaling Analysis (2010) (0)
- Crystal structure of Bcl-2 in complex with the novel orally active inhibitor S55746 (2018) (0)
- BenzoÄbÜpyranoÄ3,2-hÜacridin-7-one derivatives, to processes for their preparation and pharmaceutical compositions containing them (2002) (0)
- New dihydroindolonderivater, process for their preparation and to pharmaceutical compositions containing these (2010) (0)
- Apoptosis in the normal and malignant colon (2001) (0)
- α-HYDROXYLATED DERIVATIVES OF ANTITUMOR DIMETHYLTRIAZENES (1979) (0)
- New tricyclic derivatives, their preparation process and pharmaceutical compositions containing them (2008) (0)
- and not integrin-mediated death in human endothelial cells 5 integrins by RGD mimetics induces anoikis β (2013) (0)
- Cinnamate derivatives benzo (b) pyran (3.2-h) acridine-7-one, their preparation process and pharmaceutical compositions containing them. (2005) (0)
- alpha-Hydroxylated triazenes: potential active metabolites of anti-tumour dimethyltriazenes [proceedings]. (1978) (0)
- Cinnamates new derivatives of benzo [b] pyrano [3,2-h] acridin-7-one, their process for the preparation and pharmaceutical compositions containing them (2004) (0)
- New derivatives of benzo [e] [1,4] oxazino [3,2-g] isoindole substituted, their process for the preparation and pharmaceutical compositions containing them (2002) (0)
- ubiquitin specific proteases responsible for the stability of mcl 1 and use (2008) (0)
- Src-family kinase-dependent invasion of colon cancer cells is controlled by CBP/PAG-mediated recruitment of Csk to membrane (2009) (0)
- Oncogene-Directed Therapies (2003) (0)
- Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo [ 5 , l-onl , 2 , 3 , 5-tetrazin-4 ( 37 / )-one ( CCRG 81045 ; M & B 39831 ) , a Novel Drug with Potential as an Alternative to Dacarbazine 1 (2006) (0)
- SIGNALLING THROUGH CD40 SYNERGISES WITH BCL-2 TO DELAY DRUG INDUCED APOPTOSIS (1996) (0)
- The stability of n-hydroxymethyl compounds derived from n-methyl containing antitumour agents. Abstr. (1982) (0)
- Potentiation of the response of rat vas deferens to noradrenaline by dicylohexylamine and related amines. (1979) (0)
- New derivatives of tricyclic azepines, method of preparing them and pharmaceutical compositions containing them (2003) (0)
- Proceedings: Protection against the cytotoxic aziridine CB1954 by an arylimidazole with anti-inflammatory activity. (1975) (0)
- New camptothecin analog compounds, process for their preparation and pharmaceutical compositions containing said compounds (2006) (0)
- New derivatives of [3,4-a: 3,4-c] carbazole, their process for the preparation and pharmaceutical compositions containing them (2002) (0)
- On the relationship between uptake inhibition and reversal of alpha receptor blockade by propranolol. (1979) (0)
- The Importance of p 53-Independent Apoptosis in the Intestinal Toxicity Induced by Raltitrexed ( ZD 1694 , Tomudex ) : Genetic Differences between BALB / c and DBA / 2 Mice 1 (2000) (0)
- The Costs and Causes of Oncology Drug Attrition: The Insulin Growth Factor 1 Receptor (2022) (0)
- BCL-W expression is an important determinant of damage-induced apoptosis in murine small and large intestinal epithelium in vivo (2000) (0)
- Structural Studies on Bioactive Compounds. Part 4. A Structure-Antitumor Activity Study on Analogues of N-Methylformamide. (1986) (0)
- 9-aminopodophyllotoxinderivate, processes for their preparation and pharmaceutical compositions containing these derivatives (2004) (0)
- Structure of human Mcl-1 in complex with PUMA BH3 peptide (2019) (0)
- The role of isocyanate fragments in the antitumour activity of chloroethylnitrosoureas. Abstr. (1982) (0)
- New peptide interacting with anti-apoptotic members of the family of protein bcl-2 and uses (2005) (0)
- AMERICAN ASSOCIATION FOR CANCER RESEARCH SCIENTIFIC CONFERENCES (1995) (0)
- Regulation of chemotherpay-induced apoptosis by p53 in neuroblastoma is both cell line and agent specific. (1999) (0)
- Knowing your tumour? (2020) (0)
- Modulation of the Threshold for Apoptosis Toxin-induced Increase in Survival Factor Receptors : Updated Version (2006) (0)
- Correlation between the Molecular Weight and Potency of Polar Compounds Which Induce the Differentiation of HL-60 Human Promyelocytic Leukemia Cells1 (2006) (0)
- DEFINING COMMITMENT TO DEXAMETHASONE-INDUCED APOPTOSIS (1996) (0)
- Analogues of tjipanazoles from rebeccamycin: synthesis, in vitro antiproliferative activities, and inhibitory properties toward topoisomerase I (2004) (0)
- Camptothecin analogue compounds, processes for their preparation and pharmaceutical compositions containing them (2000) (0)
- Studies on the mode of action of the antitumour drug nitrogen mustard (mustine) [proceedings]. (1979) (0)
- DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in vitro with M&B 39565 (1984) (0)
- Abstract 5529:In vitroplatforms representing tumor complexity for target validation and drug discovery. (2013) (0)
- 239 PREDECT: in vitro models for target validation that may better represent tumor complexity (2012) (0)
- New indolocarbazole derivatives hydroxy, their process for the preparation and pharmaceutical compositions containing them (2001) (0)
- System Innovation for the Cancer Moonshot (2023) (0)
- A conformational change in the pro-apoptotic protein Bak integrates diverse cellular damage signals (1999) (0)
- Effectsof the AntitumorDrugAdriamycinon HumanRed BloodCell Discocyte-EchinocyteTransitions 1 (2006) (0)
- Abstract 1698: Systems pathology for characterization of cancer model systems in a multicenter IMI-PREDECT project (2015) (0)
- Structure of human Mcl-1 in complex with indole acid inhibitor (2019) (0)
- Structure of human Bcl-2 in complex with fragment/ABT-263 hybrid (2019) (0)
- New compounds camptothecin analogues, their process for the preparation and pharmaceutical compositions containing them (2005) (0)
- Deciphering the kinome in basal-like breast carcinoma for therapeutic usefulness (2007) (0)
- N of the bcl-2 family interacts (2004) (0)
- Antitumour Activity and Pharmacology of CCRG 81010 (NSC 353451, M&B 39565, 8-carbamoyl-3-(1-chloroethyl)imidazo [5,1-d]-1,1,3,5-tetrazin-4(3H)-one) (1984) (0)
- Up-regulated PI3K signalling pathway in basal-like breast carcinomas (2008) (0)
- Micro-environmental survival stimuli combine to regulate Bcl-XL and Bax and suppress drug-induced apoptosis in B lymphoma cells (1999) (0)
- 118. Changes in the levels of constitutively expressed but not stress-induced heat shock proteins during terminal differentiation of HL-60 human leukemia cells (1992) (0)
- Podophyllotoxin carbamate and thiocarbamate derivatives have improved anticancer activity (2000) (0)
- α‐HYDROXYLATED TRIAZENES: POTENTIAL ACTIVE METABOLITES OF ANTI‐TUMOUR DIMETHYLTRIAZENES (1978) (0)
- New compounds cyclo [d] azepane, their process for the preparation and pharmaceutical compositions containing them (2001) (0)
- Correlation of the antitumour activity of hexamethylmelamine analogues with their in vitro cytotoxicity and metabolism (1982) (0)
- BenzoÄbÜpyranoÄ3,2-hÜacridin-7-one-cinnamic acid derivatives, processes for their preparation and pharmaceutical compositions containing them (2005) (0)
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