J. Brian Houston
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Biology
J. Brian Houston's Degrees
- PhD Biochemistry University of California, San Francisco
- Masters Molecular Biology Stanford University
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)J. Brian Houston's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (1068)
- Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. (1994) (844)
- Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies (2007) (723)
- The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions (2006) (420)
- In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model. (2000) (416)
- Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. (2007) (409)
- CYP3A4 drug interactions: correlation of 10 in vitro probe substrates. (1999) (346)
- Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. (2004) (345)
- Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. (1997) (318)
- Database analyses for the prediction of in vivo drug-drug interactions from in vitro data. (2004) (274)
- Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data (2010) (267)
- Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus. (2001) (259)
- Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches (2004) (242)
- Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data (2012) (240)
- In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises. (2006) (229)
- Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes (2004) (218)
- Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance (2007) (206)
- Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7. (2003) (197)
- Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes (2009) (185)
- Optimizing Drug Development: Strategies to Assess Drug Metabolism/Transporter Interaction Potential—Toward a Consensus (2001) (178)
- Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View (2010) (176)
- SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS (2004) (176)
- BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT (2006) (172)
- Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism. (2001) (160)
- PREDICTION OF TIME-DEPENDENT CYP3A4 DRUG-DRUG INTERACTIONS: IMPACT OF ENZYME DEGRADATION, PARALLEL ELIMINATION PATHWAYS, AND INTESTINAL INHIBITION (2006) (160)
- Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism (2006) (160)
- IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM (2005) (157)
- Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant. (2005) (153)
- Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data (2008) (147)
- Drug metabolite kinetics. (1981) (145)
- Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine. (2003) (142)
- Methods for predicting in vivo pharmacokinetics using data from in vitro assays. (2008) (139)
- CYP3A4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions (2005) (134)
- Prediction of In Vivo Drug-Drug Interactions from In Vitro Data (2006) (134)
- Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential‐toward a consensus (2001) (131)
- Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential (2013) (131)
- In vitro cytochrome P450 inhibition data and the prediction of drug‐drug interactions: Qualitative relationships, quantitative predictions, and the rank‐order approach (2005) (130)
- Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs (2011) (130)
- Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam. (1997) (128)
- Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes (2012) (126)
- Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction (2011) (125)
- Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance (2009) (117)
- Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. (1999) (115)
- Characterization of In Vitro Glucuronidation Clearance of a Range of Drugs in Human Kidney Microsomes: Comparison with Liver and Intestinal Glucuronidation and Impact of Albumin (2012) (114)
- Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine. (1987) (112)
- Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data (2011) (109)
- Critique of the Two-Fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-Drug Interactions (2011) (108)
- Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model (2012) (107)
- Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. (2002) (106)
- Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. (2012) (105)
- Contribution of intestinal cytochrome p450-mediated metabolism to drug-drug inhibition and induction interactions. (2010) (104)
- Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology (2017) (103)
- Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. (2014) (98)
- In vitro human tissue models in risk assessment: report of a consensus-building workshop. (2001) (96)
- Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5*S⃞ (2008) (95)
- Modelling atypical CYP3A4 kinetics: principles and pragmatism. (2005) (92)
- In vivo assessment of extrahepatic conjugative metabolism in first pass effects using the model compound phenol (1980) (86)
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (84)
- Drug Lipophilicity and Microsomal Protein Concentration as Determinants in the Prediction of the Fraction Unbound in Microsomal Incubations (2008) (81)
- Multiple Inhibition Mechanisms and Prediction of Drug–Drug Interactions: Status of Metabolism and Transporter Models as Exemplified by Gemfibrozil–Drug Interactions (2008) (79)
- Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate. (1997) (79)
- UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES (2004) (79)
- Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat. (1999) (78)
- The six-day-old rat air pouch model of inflammation: characterization of the inflammatory response to carrageenan. (1994) (77)
- Kinetic Modeling of the Interactions between 4-Methylumbelliferone, 1-Naphthol, and Zidovudine Glucuronidation by UDP-Glucuronosyltransferase 2B7 (UGT2B7) Provides Evidence for Multiple Substrate Binding and Effector Sites (2008) (75)
- Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir (2008) (74)
- Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions (2009) (73)
- Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions (2008) (72)
- Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction (2007) (72)
- Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models. (2009) (70)
- In vivo capacity of hepatic and extrahepatic enzymes to conjugate phenol. (1984) (70)
- The Integrated Use of Alternative Methods in Toxicological Risk Evaluation (1999) (70)
- An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project. (1999) (69)
- Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data. (1995) (69)
- Determination of a Human Hepatic Microsomal Scaling Factor for Predicting in Vivo Drug Clearance (2006) (68)
- Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. (2007) (68)
- Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs (2012) (66)
- Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures. (2005) (65)
- Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for Ki Determination (2007) (64)
- In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes. (1998) (63)
- Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance (2006) (63)
- In vivo disposition of caffeine predicted from hepatic microsomal and hepatocyte data. (1995) (63)
- Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes. (1996) (62)
- Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations. (2008) (62)
- Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs. (2012) (58)
- Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man. (1983) (56)
- Methodological uncertainty in quantitative prediction of human hepatic clearance from in vitro experimental systems. (2009) (55)
- Hepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of Prodrugs (2014) (55)
- Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption. (2009) (54)
- Optimising drug development: Strategies to assess drug metabolism/transporter interaction potential - Towards a consensus (2001) (51)
- Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high- and low-clearance compounds. (1995) (50)
- PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES (2005) (50)
- Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance. (2004) (48)
- Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans (2005) (48)
- Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance (2008) (47)
- Potential role of intestinal first-pass metabolism in the prediction of drug-drug interactions. (2008) (47)
- Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance. (1995) (47)
- Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance (2011) (45)
- A Comprehensive Assessment of Repaglinide Metabolic Pathways: Impact of Choice of In Vitro System and Relative Enzyme Contribution to In Vitro Clearance (2012) (45)
- Absorption of prednisolone in patients with Crohn's disease. (1983) (45)
- Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk (2014) (42)
- Comparative Use of Isolated Hepatocytes and Hepatic Microsomes for Cytochrome P450 Inhibition Studies: Transporter-Enzyme Interplay (2010) (41)
- Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine. (1985) (40)
- Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity. (1988) (40)
- Quantitation of extrahepatic metabolism. Pulmonary and intestinal conjugation of naphthol. (1985) (40)
- Comparison of ketoconazole and fluconazole as cytochrome P450 inhibitors. Use of steady-state infusion approach to achieve plasma concentration-response relationships. (1996) (39)
- Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models. (1997) (39)
- Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance. (2008) (38)
- The Use of Biokinetics and in Vitro Methods in Toxicological Risk Evaluation (1996) (38)
- Diazepam-omeprazole inhibition interaction: an in vitro investigation using human liver microsomes. (1996) (38)
- IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4 (2010) (37)
- Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance (2018) (37)
- Azo reduction of sulphasalazine in healthy volunteers. (1982) (36)
- Relevance of in vitro kinetic parameters to in vivo metabolism of xenobiotics. (1994) (36)
- Drug metabolite concentration-time profiles: influence of route of drug administration. (1984) (33)
- Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling (2005) (33)
- Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition. (1996) (32)
- Typical and Atypical Enzyme Kinetics (2003) (31)
- Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity. (1999) (31)
- Simultaneous assay of fluoroquinolones and theophylline in plasma by high-performance liquid chromatography. (1993) (31)
- Induction of cytochromes P-450 in pancreatic disease: consequence, coincidence or cause? (1985) (31)
- Effect of vitamin C supplement on antipyrine disposition in man. (1977) (31)
- Amidopyrine disposition in rat (1979) (31)
- The Critical Role of Passive Permeability in Designing Successful Drugs (2020) (31)
- Antinuclear factor in rapid and slow acetylator patients treated with isoniazid. (1972) (31)
- Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo (2010) (30)
- Antipyrine metabolite kinetics in phenobarbital and beta-naphthoflavone-induced rats. (1983) (30)
- Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data (2013) (29)
- Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease. (1989) (29)
- Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat. (1995) (27)
- Disposition of Azole Antifungal Agents. I. Nonlinearities in Ketoconazole Clearance and Binding in Rat Liver (1993) (25)
- Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications (2008) (25)
- Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance (2018) (23)
- Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4 (2012) (23)
- Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs. (2012) (23)
- Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes. (2004) (22)
- A rapid method for the simultaneous determination of the major metabolites of sulphasalazine in plasma. (1983) (22)
- Aminopyrine demethylation kinetics. Use of metabolite exhalation rates as an index of enhanced mixed-function oxidase activity in vivo. (1981) (22)
- Utility of Drug Depletion-Time Profiles in Isolated Hepatocytes for Accessing Hepatic Uptake Clearance: Identifying Rate-Limiting Steps and Role of Passive Processes (2012) (21)
- Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation (2020) (20)
- Simultaneous determination of promethazine and two of its circulating metabolites by high-performance liquid chromatography. (1982) (19)
- Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines (2008) (19)
- Inhibition of antipyrine metabolite formation in rats in vivo. (1984) (18)
- In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages. (2017) (18)
- In vitro techniques to study drug-drug interactions of drug metabolism: Cytochrome P450 (2010) (17)
- Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells (2002) (17)
- In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383 (2015) (17)
- In Vitro–In Vivo Extrapolation of OATP1B-Mediated Drug–Drug Interactions in Cynomolgus Monkey (2018) (17)
- Effect of Omeprazole on Diazepam Disposition in the Rat: in Vitro and in Vivo Studies (1995) (17)
- Predictive Utility of In Vitro Rifampin Induction Data Generated in Fresh and Cryopreserved Human Hepatocytes, Fa2N-4, and HepaRG Cells (2011) (16)
- Drug metabolizing capacity in vitro and in vivo--I. Correlations between hepatic microsomal monooxygenase markers in beta-naphthoflavone-induced rats. (1990) (16)
- Pharmacokinetics in Early Drug Research (1997) (16)
- Antipyrine metabolite kinetics in rats: studies on dose and time dependence. (1983) (16)
- Phenol conjugation by lung in vivo. (1980) (16)
- CYP 3 A 4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions (2005) (16)
- The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: A comparison of in vitro and in vivo metabolism and in vitro enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes (2007) (16)
- Dose-dependent pharmacokinetics of cimetidine in the rat. (1987) (15)
- Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. (2008) (15)
- Influence of phenobarbitone pretreatment on disposition of amidopyrine and its metabolites in rat (1980) (14)
- Determinants of systemic availability of promethazine in rabbits (1983) (14)
- Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats. (1990) (14)
- Determination of Promethazine in Biological Fluids (1979) (14)
- Selectivity of omeprazole inhibition towards rat liver cytochromes P450. (1997) (13)
- The Validation of Computational Prediction Techniques (1998) (13)
- vitro clearance and permeability data (2010) (13)
- Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance (2019) (13)
- Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance (2018) (12)
- PLASMA CONCENTRATION‐RESPONSE RELATIONSHIP FOR CIMETIDINE INHIBITION OF DRUG METABOLISM IN THE RAT (1985) (12)
- Inhibition of antipyrine metabolite formation. Steady state studies with cimetidine and metyrapone in rats. (1986) (11)
- Regional Drug Delivery II: Relationship Between Drug Targeting Index and Pharmacokinetic Parameters for Three Non-Steroidal Anti-Inflammatory Drugs Using the Rat Air Pouch Model of Inflammation (1995) (11)
- Saliva: plasma concentration relationships for sulphapyridine following sulphasalazine administration to normal volunteers and patients with inflammatory bowel disease. (1980) (11)
- Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach (2018) (11)
- Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations. (2017) (11)
- Relationship Between Enoxacin and Ciprofloxacin Plasma Concentrations and Theophylline Disposition (1994) (11)
- UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE : IMPACT OF VARIABILITY , CYP 3 A 5 , AND CYP 2 C 19 ON CYP 3 A 4 PROBE SUBSTRATES (2004) (10)
- High-performance liquid chromatographic method for the simultaneous determination of cimetidine and antipyrine in plasma. (1985) (10)
- Impact of end-product inhibition on the determination of in vitro metabolic clearance (2005) (10)
- Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility. (2012) (10)
- The effect of rifampicin on sulphapyridine plasma concentrations following sulphasalazine administration. (1985) (10)
- Kinetics of drug metabolism inhibition: Use of metabolite concentration-time profiles (1987) (10)
- Changes in the disposition of promethazine during multiple dosing in the rabbit (1985) (9)
- Disposition of metronidazole and its effects on sulphasalazine metabolism in patients with inflammatory bowel disease. (1986) (9)
- Quantification of naphthyl conjugates. Comparison of high-performance liquid chromatography and selective enzyme hydrolysis methods. (1981) (9)
- EUFEPS conference report. Optimising drug development: strategies to assess drug metabolism/transporter interaction potential - towards a consensus. European Federation of Pharmaceutical Sciences. (2001) (9)
- Rate limiting steps in metabolite kinetics: formation of 5‐acetylaminosalicylate after administration of 5‐aminosalicylate (1982) (9)
- Influence of Slice Thickness and Culture Conditions on the Metabolism of 7-Ethoxycoumarin in Precision-cut Rat Liver Slices (1998) (8)
- Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone. (1985) (8)
- Pharmacodynamic Comparison of Regional Drug Delivery for Non‐steroidal Anti‐inflammatory Drugs, Using the Rat Air‐pouch Model of Inflammation (1995) (8)
- Effect of Norfloxacin on Theophylline Disposition: A Comparison with Other Fluoroquinolones (1995) (8)
- HPLC ANALYSIS OF SULPHASALAZINE AND ITS METABOLITES (1980) (8)
- Prediction of Human Pharmacokinetics in 2013 and Beyond (2013) (8)
- Disposition of Azole Antifimgal Agents. III. Binding of Fluconazole and Other Azoles in Rat Liver (1994) (7)
- Regional Drug Delivery I: Permeability Characteristics of the Rat 6-Day-Old Air Pouch Model of Inflammation (1995) (7)
- Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation. (1994) (7)
- Time-Dependent Disposition of β-Naphthoflavone in the Rat (2004) (6)
- Quantification of Metabolites of Aminopyrine and Antipyrine in Plasma and Urine (1983) (6)
- USE OF ISOLATED HEPATOCYTE PREPARATIONS FOR P 450 INHIBITION STUDIES : COMPARISON WITH MICROSOMES FOR KI DETERMINATION (2007) (6)
- Concentration-response relationships for three nonsteroidal anti-inflammatory drugs in the rat intestine (1995) (6)
- Interpretation of CO2 exhalation rate data from demethylation of aminopyrine and its metabolite monomethylaminoantipyrine. (1982) (5)
- Theophylline and antipyrine disposition in smoking and non-smoking epileptic subjects. (1987) (5)
- Induction of cytochrome P450: unifying factor in pancreatic disease (1984) (5)
- Use of the rat air pouch model of inflammation to evaluate regional drug delivery (2005) (4)
- Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes. (1995) (4)
- Aminopyrine demethylation kinetics: comparison of plasma and exhaled metabolites [proceedings]. (1979) (3)
- High-performance liquid chromatographic determination of beta-naphthoflavone in biological fluids. (1987) (3)
- Effects of cold stress and ether stress on aminopyrine demethylation kinetics in vivo (1982) (3)
- Disposition of Azole Antifungal Agents. II. Hepatic Binding and Clearance of Dichlorophenyl-Bis-triazolylpropanol (DTP) in the Rat (1994) (3)
- Antinuclear Factor inRapid andSlowAcetylator Patients Treated withIsoniazid (1972) (3)
- Transporters and cytochrome P450 interplay in defining hepatic drug clearance (2009) (2)
- Drug transport and binding in isolated hepatocytes: implications for intrinsic clearance determinations in hepatocytes and hepatic microsomes (1996) (2)
- Sigmoidal Kinetics of CYP 3 A Substrates : An Approach for Scaling Dextromethorphan Metabolism in Hepatic Microsomes and Isolated Hepatocytes to Predict In Vivo Clearance in Rat 1 (1999) (2)
- Use of the rat air pouch model of inflammation to evaluate regional drug delivery (2005) (2)
- Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential (2012) (2)
- Time-dependent disposition of beta-naphthoflavone in the rat. (1993) (2)
- Kinetics of disposition of xenobiotics and their metabolites. (1988) (2)
- DRUG-DRUG INTERACTIONS : CYP 2 D 6 PARADIGM (2005) (2)
- Temporal effects on antipyrine metabolite kinetics in Aroclor 1254-treated rats. (1986) (2)
- Inhibition of Drug‐Metabolizing Enzymes in the Gastrointestinal Tract and Its Influence on the Drug–Drug Interaction Prediction (2010) (1)
- The Report and Recommendations of ECVAM Workshop 22 1,2 (1997) (1)
- ANTIPYRINE METABOLITE KINETICS IN RATS (1982) (1)
- Increased Urinary D-Glucaric Acid Excretion as an Indicator of Microsomal Enzyme Induction in Pancreatic Disease (1985) (1)
- Uptake of repaglinide in HEK293 cells expressing OATP1B1 and plated human hepatocytes (2008) (1)
- Effect of pregnenolone carbonitrile, promethazine and antipyrine pretreatment on antipyrine metabolite formation in rats. (1986) (1)
- Inhibition of Drug Metabolizing Enzymes in Gastrointestinal Tract and its Influence on the Drug-Drug Interaction Prediction, in Enzyme Inhibition in Drug Discovery and Development (2010) (1)
- IN‐VITRO AND IN‐VIVO ACTION OF MECHANISM‐BASED INHIBITORS OF OXIDATIVE DRUG METABOLISM (1990) (1)
- USE OF GOLDFISH TURNOVER TIME IN PREDICTING GASTROINTESTINAL ABSORPTION (1978) (1)
- DETERMINANTS OF SYSTEMIC AVAILABILITY OF MORPHINE AND BUPRENORPHINE IN THE RAT (1981) (1)
- PHARMACOKINETICS OF PROMETHAZINE FOLLOWING MULTIPLE DOSING IN THE RABBIT (1980) (1)
- PHARMACOKINETICS OF ETHOXYCOUMARIN AND HYDROXYCOUMARIN IN THE URETHANE‐ANAESTHETISED RAT (1985) (1)
- . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin (2009) (0)
- IN‐VIVO DETERMINATIONS OF THE POTENCY OF KETOCONAZOLE IN INHIBITING DRUG METABOLISM IN THE RAT (1986) (0)
- Determination of the fraction metabolised by phase II (UGT) enzymes using human cryopreserved hepatocytes and 1-aminobenzo-triazole (ABT) (2007) (0)
- Application of different in vitro systems for prediction of in vivo induction drug-drug interactions (2010) (0)
- In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383 (2015) (0)
- Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance (2018) (0)
- Drug accumulation in alveolar macrophages: assessment of uptake and lysosomal distribution in vitro. (2013) (0)
- Drug clearance in different in vitro systems as a preliminary indicator of hepatic uptake (2010) (0)
- In vitro-in vivo extrapolation of drug glucuronidation kinetic parameters: Pitfalls and Promises (2007) (0)
- In vitro assessment of accumulation of inhaled drugs by alveolar macrophages (2012) (0)
- Comparison of Metabolism and Transporter Models for Predicting Gemfibrozil Drug-Drug Interactions. (2006) (0)
- QGut Model as a Predictive Tool for Intestinal Availability in Human: Impact of In Vitro Permeability and Clearance (2009) (0)
- Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes (2010) (0)
- The Prediction of Systemic Toxicity by Integrating the Results of Biokinetic Models and Biologically Based In Vitro Test Methods (2002) (0)
- microsomes: Comparison to liver and intestinal glucuronidation and impact of albumin (2012) (0)
- EFFECT OF STRUCTURAL MODIFICATIONS ON DRUG‐HEPATIC MICROSOMAL INTERACTIONS (1977) (0)
- Multisite kinetic modelling of interactions between UDP-glucuronosyltransferase 2B7 (UGT2B7) substrates. (2006) (0)
- Development of physiological models incorporating transporter and enzyme interplay for clearance and DDI prediction (2010) (0)
- INFLUENCE OF ROUTE OF ADMINISTRATION OF β‐NAPHTHOFLAVONE ON INDUCTION OF DRUG METABOLISM IN VARIOUS TISSUES OF THE RAT (1986) (0)
- Interplay between enzymes and transporters in defining hepatic drug clearance and intracellular concentration of drugs (2014) (0)
- Role of Pharmacokinetics in Rationalizing Tissue Distribution (2019) (0)
- Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol (2020) (0)
- DMD # 36103 1 Critique of the two-fold measure of prediction success for ratios : application for the assessment of drug-drug interactions (2010) (0)
- Predictive hepatocellular activity: Cornerstone for PBPK modelling (B2) (2012) (0)
- Disposition ofmetronidazole andits effects onsulphasalazine metabolism inpatients withinflammatory bowel disease (1986) (0)
- PREDICTION OF PHENYTOIN CLEARANCE IN‐VIVO FROM IN‐VITRO PHENYTOIN OXIDASE ACTIVITY (1990) (0)
- DMD050294 744..753 (2013) (0)
- Impact of Inter-Liver Variability on in vitro to in vivo metabolic clearance predictions (2006) (0)
- Overview of the results of the ECVAM workshop on the use of biokinetics and in vitro methods in toxicological risk evaluation. In: Anderson JG, Katzper M (eds) Simulation in the Medical Sciences. (1997) (0)
- P450 and UGT cofactors in alamethicin activated human liver microsomes (2008) (0)
- The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: Investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human (2007) (0)
- Variability in Heteroactivation of Carbamazepine Metabolism by Endogenous Steroids: Comparison of CYP3A4 and CYP3A5 Response. (2006) (0)
- Physiologically-based pharmacokinetic modelling of hepatic transporter substrate rosuvastatin (2010) (0)
- Inhibition of Repaglinide Metabolism by Gemfibrozil in Microsomes and Hepatocytes. (2006) (0)
- Evaluation of the transporter-mediated hepatic uptake in fresh rat hepatocytes (2009) (0)
- Assessment of the contribution of transporter-mediated active uptake to the overall hepatic uptake clearance for a range of drugs (2009) (0)
- Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk (2014) (0)
- Evaluation of novel in vitro systems for low hepatic clearance and assessment of their predictive utility. (2013) (0)
- JPET #93229 1 THE UTILITY OF IN VITRO CYTOCHROME P450 INHIBITION DATA IN THE PREDICTION OF DRUG-DRUG INTERACTIONS (2005) (0)
- In vitro approaches for prediction of human drug clearance and drug-drug interactions (2006) (0)
- Transporters and enzyme interplay in defining hepatic clearance (2008) (0)
- Bias in scaling in vitro clearance data: comparison of CYP activity cryopreserved human hepatocytes and microsomes prepared from the same donor livers (2006) (0)
- Addressing the challenges of low clearance. (2013) (0)
- INDUCTION OF DRUG METABOLISING CAPACITY IN THE RAT BY DI‐(2‐ETHYLHEXYL) PHTHALATE (1985) (0)
- In vitro to in vivo translation of OATP-mediated drug–drug interactions in cynomolgus monkey (2018) (0)
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What Schools Are Affiliated With J. Brian Houston?
J. Brian Houston is affiliated with the following schools:
