Jack B. Penney

Q: What Schools Are Affiliated With Jack B. Penney

Jack B. Penney is affiliated with the following schools: University College London, University of Michigan, Massachusetts General Hospital

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Jack B. Penney

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#9406

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Jack B. Penney

Biology

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#11781

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Neuroscience

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#1257

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Philosophy
Biology

Jack B. Penney's Degrees

PhD Neuroscience Stanford University
Doctorate Medicine Stanford University

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Jack B. Penney's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The functional anatomy of basal ganglia disorders (1989) (5064)
Unified Huntington's disease rating scale: Reliability and consistency (1996) (1393)
Trinucleotide repeat length instability and age of onset in Huntington's disease (1993) (1083)
Differential loss of striatal projection neurons in Huntington disease. (1988) (982)
Effect of deprenyl on the progression of disability in early Parkinson's disease. (1989) (886)
Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. (2004) (713)
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease (1999) (642)
CAG repeat number governs the development rate of pathology in Huntington's disease (1997) (623)
Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene. (1998) (527)
Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system (1989) (440)
Speculations on the functional anatomy of basal ganglia disorders. (1983) (432)
NMDA receptor losses in putamen from patients with Huntington's disease. (1988) (408)
Organization of N‐methyl‐D‐aspartate glutamate receptor gene expression in the basal ganglia of the rat (1994) (379)
Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites. (1985) (375)
Homozygotes for Huntington's disease (1987) (372)
Excitatory amino acid binding sites in the basal ganglia of the rat: A quantitative autoradiographic study (1992) (372)
Distribution and kinetics of GABAB binding sites in rat central nervous system: A quantitative autoradiographic study (1990) (366)
Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa (1996) (356)
Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease (1992) (354)
Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system (1984) (353)
Huntingtin localization in brains of normal and Huntington's disease patients (1997) (352)
Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases. (1985) (348)
The functional anatomy of disorders of the basal ganglia (1995) (347)
Glutamate dysfunction in Alzheimer's disease: an hypothesis (1987) (342)
Striatal inhomogeneities and basal ganglia function (1986) (333)
PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline (1986) (297)
Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[3H]Glutamate Binding (1987) (294)
Striatal and nigral neuron subpopulations in rigid Huntington's disease: Implications for the functional anatomy of chorea and rigidity‐akinesia (1990) (285)
Comparative distribution of dopamine D‐1 and D‐2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys (1987) (273)
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease. (1990) (265)
Impact of sustained deprenyl (selegiline) in levodopa‐treated Parkinson's disease: A randomized placebo‐controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial (2002) (251)
Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease. (1999) (249)
GABA as the pallidothalamic neurotransmitter: implications for basal ganglia function (1981) (240)
Huntington's disease in venezuela: 7 years of follow‐up on symptomatic and asymptomatic individuals (1990) (231)
Metabotropic glutamate receptors are differentially regulated during development (1994) (231)
Huntington's disease gene: Regional and cellular expression in brain of normal and affected individuals (1995) (222)
Gametic but not somatic instability of CAG repeat length in Huntington's disease. (1993) (201)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2 (1998) (200)
Differential loss of striatal projection systems in Huntington’s disease: a quantitative immunohistochemical study (2004) (200)
Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons (1995) (190)
Expression of group one metabotropic glutamate receptor subunit mRNAs in neurochemically identified neurons in the rat neostriatum, neocortex, and hippocampus. (1997) (188)
Expression of Normal and Mutant Huntingtin in the Developing Brain (1996) (187)
Changes in [3H]muscimol binding in substantia nigra, entopeduncular nucleus, globus pallidus, and thalamus after striatal lesions as demonstrated by quantitative receptor autoradiography (1983) (178)
Novel mutation in the TOR1A (DYT1) gene in atypical, early onset dystonia and polymorphisms in dystonia and early onset parkinsonism (2001) (178)
Expression of α‐synuclein, parkin, and ubiquitin carboxy‐terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease (2000) (178)
Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus. (1996) (177)
CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain (1995) (177)
Glutamate transmission and toxicity in alzheimer's disease (1988) (177)
Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease. (1999) (175)
Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis (1995) (168)
Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function (1988) (167)
Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia (1999) (164)
Huntington's disease in Venezuela (1986) (161)
γ‐Aminobutyric Acid and Benzodiazepine Receptor Changes Induced by Unilateral 6‐Hydroxydopamine Lesions of the Medial Forebrain Bundle (1985) (158)
Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat. (1999) (144)
3‐Nitropropionic Acid Toxicity in the Striatum (1994) (144)
Decreased glutamate uptake in subcortical areas deafferented by sensorimotor cortical ablation in the cat (1981) (142)
Distribution of the mRNAs encoding torsinA and torsinB in the normal adult human brain (1999) (136)
Differential expression of metabotropic glutamate receptors in the hippocampus and entorhinal cortex of the rat. (1994) (132)
Imaging of a glioma using peripheral benzodiazepine receptor ligands. (1987) (127)
Expression of N‐Methyl‐D‐Aspartate receptor subunit mRNAs in the human brain: Hippocampus and cortex (1998) (124)
Quantitative autoradiography of [3H]muscimol binding in rat brain. (1981) (122)
At-risk persons' attitudes toward presymptomatic and prenatal testing of Huntington disease in Michigan. (1987) (122)
High correlation between the localization of [3H]TCP binding and NMDA receptors. (1986) (122)
Quantitative autoradiography of neurotransmitter receptors in Huntington disease (1982) (119)
Comparative distributions of dopamine D‐1 and D‐2 receptors in the cerebral cortex of rats, cats, and monkeys (1989) (118)
Regional distribution and properties of [3H]MK-801 binding sites determined by quantitative autoradiography in rat brain (1991) (115)
Excitatory amino acid binding sites in the trigeminal principal sensory and spinal trigeminal nuclei of the rat (1992) (113)
Expression of the early‐onset torsion dystonia gene (DYT1) in human brain (1998) (113)
Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum (2000) (111)
Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. (1990) (107)
Glutamate receptors in striatum and substantia nigra: Effects of medial forebrain bundle lesions (1994) (103)
Loss of hippocampal [3H]TCP binding in Alzheimer's disease (1987) (92)
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of huntington's disease (1991) (91)
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease. (2000) (91)
Cortical GABAB and GABAA receptors in Alzheimer's disease (1987) (90)
Regionally Distinct N‐Methyl‐D‐Aspartate Receptors Distinguished by Quantitative Autoradiography of [3H]MK‐801 Binding in Rat Brain (1993) (88)
Normal caudate glucose metabolism in persons at risk for Huntington's disease. (1987) (84)
Genome-wide significance for a modifier of age at neurological onset in Huntington's Disease at 6q23-24: the HD MAPS study (2006) (83)
Benzodiazepine and GABA receptors in early Huntington's disease (1984) (82)
Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse (1987) (82)
Glutamate receptors in the substantia nigra of Parkinson's disease brains (1992) (82)
l-[3H]Glutamate labels the metabotropic excitatory amino acid receptor in rodent brain (1990) (80)
Dopamine‐receptor autoradiography of human narcoleptic brain (1992) (79)
Evidence for the presynaptic localization of opiate binding sites on striatal efferent fibers (1984) (77)
Positron emission tomography measures of benzodiazepine receptors in Huntington's disease (1993) (76)
Compartmentalization of excitatory amino acid receptors in human striatum. (1992) (74)
Excitatory amino acid binding sites in the periaqueductal gray of the rat (1990) (73)
Glutamate or aspartate as a possible neurotransmitter of cerebral corticofugal fibers in the monkey (1983) (73)
Preproenkephalin messenger RNA—containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study (1991) (72)
Longitudinal neuropsychological and genetic linkage analysis of persons at risk for Huntington's disease. (1995) (71)
Characterization and regional distribution of strychnine-insensitive [3H]glycine binding sites in rat brain by quantitative receptor autoradiography (1990) (71)
Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease (1987) (70)
Huntingtin Immunoreactivity in the Rat Neostriatum: Differential Accumulation in Projection and Interneurons (1997) (68)
Glutamate receptor expression in rat striatum: Effect of deafferentation (1994) (68)
Alternatively spliced isoforms of the NMDAR1 glutamate receptor subunit: Differential expression in the basal ganglia of the rat (1993) (67)
The globus pallidus receives a projection from the parafascicular nucleus in the rat (1991) (67)
Primary culture of capillary endothelium from rat brain (1981) (66)
Thiocyanate stabilizes AMPA binding to the quisqualate receptor. (1988) (66)
Expression of N‐Methyl‐D‐Aspartate receptor subunit mRNAs in the human brain: Striatum and globus pallidus (1998) (66)
Evidence for a projection from the globus pallidus to the entopeduncular nucleus in the rat (1991) (64)
The Role of Group I and Group II Metabotropic Glutamate Receptors in Modulation of Striatal NMDA and Quinolinic Acid Toxicity (2001) (63)
NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex (1993) (58)
Quisqualate‐ and NMDA‐sensitive [3H]glutamate binding in primate brain (1990) (58)
Properties of Quisqualate‐Sensitive L‐[3H]Glutamate Binding Sites in Rat Brain as Determined by Quantitative Autoradiography (1988) (57)
6-Hydroxydopamine lesions of the nigrostriatal pathway alter the expression of glutamate decarboxylase messenger RNA in rat globus pallidus projection neurons (1992) (57)
Properties of D2 dopamine receptor autoradiography: High percentage of high-affinity agonist sites and increased nucleotide sensitivity in tissue sections (1986) (57)
Expression of metabotropic glutamate receptor 1 isoforms in the substantia nigra pars compacta of the rat (1998) (54)
Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials. (2016) (54)
Adenine arabinoside in the treatment of progressive multifocal leukoencephalopathy: Use of virus‐containing cells in the urine to assess response to therapy (1977) (53)
The gene (DYT1) for early-onset torsion dystonia encodes a novel protein related to the Clp protease/heat shock family. (1998) (51)
Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease. (2002) (49)
Differential expression of kainate receptors in the basal ganglia of the developing and adult rat brain (1997) (49)
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. (1988) (49)
Metabotropic receptors in excitotoxicity: (S)-4-carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) protects against rat striatal quinolinic acid lesions (1995) (48)
Localization of dopaminergic markers in the human subthalamic nucleus (2000) (46)
Quantitative autoradiography of L-[3H]glutamate binding to rat brain (1983) (46)
Neurochemical anatomy of movement disorders. (1984) (45)
Metabotropic glutamate receptor heterogeneity in rat brain. (1994) (45)
Stereotactic pallidotomy performed without using microelectrode guidance in patients with Parkinson's disease: surgical technique and 2-year results. (2000) (44)
Basal ganglia glucose utilization after recent precentral ablation in the monkey (1985) (43)
Glutamate Receptor Dysregulation in the Hippocampus of Transgenic Mice Carrying Mutated Human Amyloid Precursor Protein (2001) (43)
Expression of N‐Methyl‐D‐Aspartate receptor subunit mRNA in the human brain: Mesencephalic dopaminergic neurons (1998) (42)
Chorea and dystonia: A remote effect of carcinoma (1988) (41)
N-Acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo (1997) (39)
Phospholipase A2 Modulates Different Subtypes of Excitatory Amino Acid Receptors: Autoradiographic Evidence (1993) (38)
Repeat instability in the 27–39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications (2009) (37)
Tetrahydro-9-aminoacridine (THA) interacts with the phencyclidine (PCP) receptor site (1988) (35)
A controlled trial of lazabemide (Ro 19-6327) in levodopa-treated Parkinson's disease. Parkinson Study Group. (1994) (35)
Basal ganglia and cerebral cortical distribution of dopamine D1- and D2-receptors in neonatal and adult cat brain (1987) (33)
Excitatory amino acid receptor regulation after subthalamic nucleus lesions in the rat (1993) (33)
Multiple states of rat brain (RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors as revealed by quantitative autoradiography. (1992) (32)
Quantitative autoradiography of neurotransmitter receptors using tritium-sensitive film. (1981) (32)
Simultaneous isotopic and nonisotopic in situ hybridization histochemistry with cRNA probes. (1998) (31)
Cellular Distribution of NMDA Glutamate Receptor Subunit mRNAs in the Human Cerebellum (1997) (30)
2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA) displaces [3H]AMPA binding in rat striatum (1991) (29)
Experimental hemiplegia in the monkey: Basal ganglia glucose activity during recovery (1987) (29)
Localization of non–N‐methyl‐D‐aspartate glutamate receptors in normal and Alzheimer hippocampal formation (1994) (29)
Regional ontogeny of a unique glutamate recognition site in rat brain: An autoradiographic study (1990) (28)
Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites. (1993) (27)
Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson’s disease brains (1998) (26)
Glutamate Receptor Binding Sites in MPTP-Treated Mice (1993) (26)
Characterization of benzodiazepine receptor changes in substantia nigra, globus pallidus and entopeduncular nucleus after striatal lesions. (1984) (24)
Muscarinic cholinergic receptors in human infant forebrain: [3H]quinuclidinyl benzilate binding in homogenates and quantitative autoradiography in sections. (1985) (23)
IT15 gene expression in fetal human brain (1994) (23)
Excitatory amino acid, GABA(A), and GABA(B) binding sites in human striate cortex. (1991) (22)
The importance of accurate lesion placement in posteroventral pallidotomy. Report of two cases. (1998) (21)
Comparison of [14C]‐deoxyglucose metabolism and peripheral benzodiazepine receptor binding in rat C6 glioma (1988) (20)
Chapter III Chemical architecture of the basal ganglia (1999) (20)
Cerebellar excitatory amino acid binding sites in normal, granuloprival, and purkinje cell-deficient mice (1991) (20)
Multiple systems atrophy and nonfamilial olivopontocerebellar atrophy are the same disease (1995) (18)
[14C]-2-deoxyglucose uptake in monkeys with hypotonic hemiplegia after precentral or postcentral lesions (1980) (18)
Imaging the Dopamine Uptake Site with Ex Vivo [18F]GBR 13119 Binding Autoradiography in Rat Brain (1990) (17)
Autoradiographic evidence for increased dopamine uptake sites in striatum of hypoxic mice (1994) (17)
A study of cortical and hippocampal NMDA and PCP receptors following selective cortical and subcortical lesions (1991) (16)
Chapter 2 – Benzodiazepine, GABA, and Glutamate Receptors in Cerebral Cortex, Hippocampus, Basal Ganglia, and Cerebellum (1991) (13)
Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey (1988) (13)
Cerebellar excitatory and inhibitory amino acid receptors in multiple system atrophy (1993) (13)
Normal caudate glucose metabolism in persons at risk for Huntington??s disease (1987) (12)
GABA and benzodiazepine receptors in basal ganglia function (1984) (11)
Quantitative autoradiography of GABA and benzodiazepine binding in studies of mammalian and human basal ganglia function (1986) (11)
Excitatory and inhibitory amino acid binding sites in human dentate nucleus (1991) (9)
In vivo [3H]flunitrazepam binding: imaging of receptor regulation. (1986) (9)
Deprenyl for the treatment of early Parkinson's disease. (1990) (6)
Reply from W.F. Maragos and colleagues (1987) (4)
Selective metabotropic receptor agonists distinguish non-ionotropic glutamate binding sites (1997) (4)
The role of mitochondrial DNA in Huntington’s disease (2008) (4)
Subject Index Vol. 72, 1999 (2000) (4)
Evidence for reactive synaptogenesis in the ventrolateral thalamus and red nucleus of the rat: changes in high affinity glutamate uptake and numbers of corticofugal fiber terminals (2004) (3)
Intraventricular Administration of a Caspase Inhibitor Delays Disease Progression and Mortality in a Mouse Model of Huntington's Disease (1999) (3)
Outcomes assessment for pallidotomy. (1997) (3)
Computer-assisted estimates of lesion sizes and shrinkage in denervated areas from receptor autoradiograms using a digitizing tablet (1984) (3)
Basal ganglia glucose metabolic and single neural unit activity in experimental hemiplegia. (1984) (3)
Non-microelectrode Guided Pallidotomy for Parkinson's Disease: Analysis of 73 Cases: 778 (1997) (3)
Glutamate receptor genes in Parkinson's disease. (1996) (3)
Immunohistochemical localization of metabotropic glutamate receptors (mGluRs) in the rat basal ganglia (1996) (2)
Striatal Inhomogeneities and Basal (1986) (2)
NONAGENARIANS WITH HUNTINGTON DISEASE (HD) HAVE LOW CAG REPEATS (1999) (1)
Excitatory amino acidergic pathways and receptors in the basal ganglia (1991) (1)
L-glutamate uptake decreases in lumbar and cervical spinal cord of monkey contralateral to sensorimotor ablations (1981) (1)
Metabotropic glutamate receptors modulate striatal quinolinic acid toxicity (1996) (1)
Characteristics of muscarinic acetylcholine receptors in neonatal and adult human brain (1982) (1)
Reply (1996) (1)
NON-MICROELECTRODE GUIDED PALLIDOTOMY FOR PARKINSON'S DISEASE: ANALYSIS OF 73 CASES (1998) (1)
What We Know and What We Have Left to Learn (2001) (1)
REGIONAL ONTOGENY OF A UNIQUE GLUTA~A~ R~COGNI~O~ SITE IN RAT BRAIN: AN AUTORA~IOGRA~H~C (1990) (0)
Stereotactic Pallidotomy for Parkinson's Disease: Long Term Results (1999) (0)
Neurotransmitters and Receptors in the Basal Ganglia (2019) (0)
Reply (1998) (0)
Inhibitionof caspase-1 slowsdiseaseprogression inamousemodel ofHuntington ’ sdisease (0)
Recent Basal Gangha Glucose Uthzation after Precentral Ablation in the Monkey (2004) (0)
Role of the Cerebellum and Basal Ganglia in Voluntary Movement (Proceedings of the 8th Tokyo Metropolitan Institute for Neuroscience [TMIN] International Symposium [20th Anniversary of TMIN], Tokyo, 17‐19 November 1992) (1994) (0)
Reply (1996) (0)
The role of mitochondrial DNA in Huntington's disease (2008) (0)
D 1 and d 2 dopamine receptor quantitative autoradiography using tritiated n propylnorapomorphine (1985) (0)
D 1 and d 2 dopamine receptor distributions in kitten and monkey striatum (1986) (0)
Excitatory Armno Acid Binding Sites in the Caudate Nucleus and Frontal Cortex of Huntington ’ s Disease (2004) (0)
Gametic butnotsomatic instability ofCAG repeat length inHuntington's disease (1993) (0)
Receptors in the Basal Ganglia (1989) (0)
Anatomical And Pharmacological Comparisons Between Dopamine D-1 And D-2 Receptors In Mammalian Cns (1988) (0)
QUANTITATIVE A U T O ~ D I O G ~ H Y OF L-I3HIGLUTAMATE BINDING TO RAT BRAIN (2002) (0)
Huntington's disease introduction to diagnosis, genetics, and management (slide library) (1996) (0)
Twelfth annual symposia on etiology, pathogenesis, and treatment of parkinson's disease and etiology, pathogenesis, and treatment of Huntington's disease (1998) (0)
Preproenkephahn Messenger RNA-containing Neurons in Striatwn of Patients with Symptomatic and Presymptomatic Huntington ’ s Disease : An In Situ Hybridization Study (2004) (0)
Reply (1990) (0)
Glutamate Receptors and Glutamate Corticofugal Pathways (1986) (0)
QUANTITATIVE AUTO~DIOG~HY OF L-I3HIGLUTAMATE BINDING TO RAT BRAIN (1983) (0)

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Published Works

What Schools Are Affiliated With Jack B. Penney?

Jack B. Penney's AcademicInfluence.com Rankings