J. Carl Barrett

Q: What Schools Are Affiliated With J. Carl Barrett

J. Carl Barrett is affiliated with the following schools: University of Southern Denmark, MD Anderson Cancer Center, The Nippon Dental University, Ohio State University, Baylor College of Medicine, Cornell University, Johns Hopkins University, National Taiwan University, University of Würzburg, Duke University

J. Carl Barrett's AcademicInfluence.com Rankings

J. Carl Barrett

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#4093

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#6484

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#1633

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#2435

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J. Carl Barrett

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#5262

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#7698

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Molecular Biology

#458

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#467

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Genetics

#469

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#540

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J. Carl Barrett's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. (2004) (2947)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (2005) (1265)
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. (2014) (1041)
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. (1996) (980)
Acquired EGFR C797S mediates resistance to AZD9291 in advanced non-small cell lung cancer harboring EGFR T790M (2015) (926)
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (1995) (811)
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks (2004) (738)
Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung Cancer. (2016) (635)
PTEN/MMAC1 mutations in endometrial cancers. (1997) (563)
Clinical proteomics: translating benchside promise into bedside reality (2002) (550)
VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research (2015) (533)
Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial. (2015) (478)
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase (1999) (428)
Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. (1999) (424)
EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291. (2015) (419)
BRCA1, Histone H2AX Phosphorylation, and Male Meiotic Sex Chromosome Inactivation (2004) (392)
Osimertinib As First-Line Treatment of EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer. (2017) (384)
Gene Expression Profiles of Serous, Endometrioid, and Clear Cell Subtypes of Ovarian and Endometrial Cancer (2005) (380)
A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. (2008) (371)
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. (2004) (354)
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. (1995) (339)
Evidence for the progressive nature of neoplastic transformation in vitro. (1978) (331)
Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial (2014) (326)
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. (1998) (320)
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary. (2005) (310)
Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. (1996) (304)
Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein (2001) (290)
PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. (1998) (278)
Gene expression analysis reveals chemical-specific profiles. (2002) (277)
Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. (2004) (271)
High-resolution serum proteomic features for ovarian cancer detection. (2004) (267)
Mechanisms of acquired resistance to first-line osimertinib: Preliminary data from the phase III FLAURA study. (2018) (265)
Chemically induced aneuploidy in mammalian cells: mechanisms and biological significance in cancer. (1986) (264)
Prediction of compound signature using high density gene expression profiling. (2002) (261)
Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. (1998) (242)
Mechanisms of multistep carcinogenesis and carcinogen risk assessment. (1993) (239)
Induction of apoptosis by c-Fos protein (1996) (235)
Gap junction function and cancer. (1993) (233)
Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension. (1984) (233)
Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project (2020) (231)
Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. (1992) (231)
Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples. (2015) (230)
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer (2018) (229)
A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2. (2009) (228)
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. (1999) (224)
Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer. (2003) (218)
Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis. (1983) (217)
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. (2003) (215)
Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation. (1999) (208)
Induction of gene amplification by arsenic. (1988) (207)
AKT Inhibition in Solid Tumors With AKT1 Mutations. (2017) (206)
Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. (2005) (202)
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. (1997) (200)
Induction of cellular senescence in immortalized cells by human chromosome 1. (1990) (198)
Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair (1996) (197)
The Immunoscore: Colon Cancer and Beyond (2019) (196)
Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. (1985) (195)
Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells. (2005) (192)
PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer (2010) (186)
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. (1981) (186)
Regulation of p53 stability and activity in response to genotoxic stress. (2000) (185)
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. (1995) (183)
Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control. (1991) (183)
Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion (2004) (181)
Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers (2005) (181)
Testing guidelines for hereditary non-polyposis colorectal cancer (2004) (181)
Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells (2004) (179)
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. (2004) (179)
The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. (2005) (178)
Analysis of resistance mechanisms to osimertinib in patients with EGFR T790M advanced NSCLC from the AURA3 study. (2018) (177)
Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture. (1984) (172)
Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells. (1997) (171)
Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. (2006) (169)
Functional overlap in mismatch repair by human MSH3 and MSH6. (1998) (153)
Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. (1985) (152)
Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. (1992) (152)
Breast cancer and environmental risk factors: epidemiological and experimental findings. (1996) (149)
Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines. (1979) (149)
Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes (1999) (148)
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation (2018) (147)
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes (2015) (146)
Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa (1989) (142)
Loss of KAI1 expression in the progression of colorectal cancer. (1999) (141)
Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers. (1989) (137)
Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways (2004) (134)
Microarrays: the use of oligonucleotides and cDNA for the analysis of gene expression. (2003) (133)
A defined chromosome 6q fragment (at D6S310) harbors a putative tumor suppressor gene for breast cancer. (1996) (132)
Mutation of β-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis (1999) (130)
Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function. (1995) (128)
Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. (2004) (126)
Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes. (1992) (125)
Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics (2002) (125)
Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3 (1995) (124)
Tumour promoters induce mitotic aneuploidy in yeast (1981) (123)
The carcinogenesis bioassay in perspective: application in identifying human cancer hazards. (1995) (122)
Avoided and avoidable risks of cancer. (1997) (120)
Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. (2006) (120)
Three microarray platforms: an analysis of their concordance in profiling gene expression (2005) (118)
Relationship between somatic mutation and neoplastic transformation. (1978) (117)
Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs. (1982) (113)
Investigation of the role of G1/S cell cycle mediators in cellular senescence. (1993) (112)
Orthogonal Comparison of Four Plasma NGS Tests With Tumor Suggests Technical Factors are a Major Source of Assay Discordance. (2019) (110)
Prognostic and predictive impact of circulating tumor DNA in patients with advanced cancers treated with immune checkpoint blockade. (2020) (109)
Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancers. (2003) (108)
An Alu polymorphism intragenic to the TP53 gene. (1991) (105)
Growth and differentiation of hamster tracheal epithelial cells in culture. (1984) (105)
A gene involved in control of human cellular senescence on human chromosome 1q (1994) (104)
Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization (2017) (103)
Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes (1985) (99)
Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men. (1995) (99)
Microarray Analysis of Endometrial Carcinomas and Mixed Mullerian Tumors Reveals Distinct Gene Expression Profiles Associated with Different Histologic Types of Uterine Cancer (2005) (99)
Favorable Survival Associated With Microsatellite Instability in Endometrioid Endometrial Cancers (2001) (98)
Genetic and cellular basis of multistep carcinogenesis. (1990) (98)
Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor. (2001) (98)
Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. (2002) (97)
Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland (2001) (97)
Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition. (2004) (97)
Allelotype of endometrial carcinoma. (1994) (95)
Possible cellular and molecular mechanisms for asbestos carcinogenicity. (1992) (95)
Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers. (2000) (95)
A hPMS2 Mutant Cell Line Is Defective in Strand-specific Mismatch Repair (*) (1995) (94)
Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. (2005) (93)
Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer. (1990) (91)
Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero (1996) (91)
Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1. (1995) (90)
Multiple pathways to cellular senescence: role of telomerase repressors. (1997) (89)
cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. (2001) (88)
Role of phagocytosis in Syrian hamster cell transformation and cytogenetic effects induced by asbestos and short and long glass fibers. (1986) (88)
Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression. (2002) (88)
Differential suppression of mammary and prostate cancer metastasis by human chromosomes 17 and 11. (1994) (87)
Defining actionable mutations for oncology therapeutic development (2016) (87)
Neoplastic transformation induced by a direct perturbation of DNA (1978) (87)
Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines (1998) (85)
Genetic analysis of cellular senescence. (1995) (85)
Comparison of spontaneous mutation rates of normal and chemically transformed human skin fibroblasts. (1983) (84)
Evidence for multiple pathways to cellular senescence. (1994) (84)
The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. (2004) (83)
Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting (2017) (83)
Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells. (1986) (82)
A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA-Mutated Breast and Gynecologic Cancers (2017) (81)
KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins † (2001) (80)
Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetra-decanoylphorbol-13-acetate. (1982) (80)
Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. (2005) (79)
Human Papillomavirus E2 Down-regulates the Human Telomerase Reverse Transcriptase Promoter* (2002) (77)
Prediction of Lymph Node Metastasis in Patients with Endometrioid Endometrial Cancer Using Expression Microarray (2006) (77)
Direct isolation of human BRCA2 gene by transformation-associated recombination in yeast. (1997) (77)
The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions (2002) (76)
Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes. (2003) (76)
17beta-Estradiol-induced cell transformation and aneuploidy of Syrian hamster embryo cells in culture. (1987) (76)
An early, nonrandom karyotypic change in immortal Syrian hamster cell lines transformed by asbestos: trisomy of chromosome 11. (1986) (76)
Chemically induced mammary gland cancer in the National Toxicology Program's carcinogenesis bioassay. (1995) (75)
Upregulation of the KIAA1199 gene is associated with cellular mortality. (2006) (74)
Butyric acid suppression of the in vitro neoplastic state of Syrian hamster cells (1978) (74)
Neoplastic transformation of cultured mammalian cells by estrogens and estrogenlike chemicals. (1997) (74)
Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress. (2001) (73)
Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. (1980) (73)
Genomic organization of the human KAI1 metastasis-suppressor gene. (1997) (71)
A preneoplastic stage in the spontaneous neoplastic transformation of syrian hamster embryo cells in culture. (1980) (71)
Progestin and estrogen potency of combination oral contraceptives and endometrial cancer risk. (2006) (70)
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells (2011) (69)
Location of KAI1 on the short arm of human chromosome 11 and frequency of allelic loss in advanced human prostate cancer (1997) (69)
Cellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessment. (1987) (69)
Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus. (1998) (68)
Assessment of genotoxicity of 14 chemical agents used in dental practice: ability to induce chromosome aberrations in Syrian hamster embryo cells. (2006) (68)
Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system. (2004) (68)
Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer. (1994) (68)
Functional evidence for a colorectal cancer tumor suppressor gene at chromosome 8p22-23 by monochromosome transfer. (1996) (67)
Ability of fourteen chemical agents used in dental practice to induce chromosome aberrations in Syrian hamster embryo cells. (2005) (67)
Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10 (1995) (67)
A mammalian cellular system for the concomitant study of neoplastic transformation and somatic mutation. (1978) (67)
Colcemid-induced neoplastic transformation and aneuploidy in Syrian hamster embryo cells. (1984) (66)
Reproducible, Quantitative, and Flexible Molecular Subtyping of Clinical DLBCL Samples Using the NanoString nCounter System (2014) (66)
Use of cell transformation systems for carcinogenicity testing and mechanistic studies of carcinogenesis. (1984) (65)
Global Expression Analysis of Cancer/Testis Genes in Uterine Cancers Reveals a High Incidence of BORIS Expression (2007) (65)
Functional copies of a human gene can be directly isolated by transformation-associated recombination cloning with a small 3' end target sequence. (1998) (65)
Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell cultures. (1983) (65)
Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene. (1977) (64)
Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acid. (1974) (63)
Tracheal epithelial cell transformation: a model system for studies on neoplastic progression. (1984) (63)
Mechanisms of arsenic-induced cell transformation (1989) (62)
DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma. (2003) (62)
Evidence for multiple steps in neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells following transfection with Harvey murine sarcoma virus oncogene (v-Ha-ras). (1985) (60)
In vitro degradation of radiolabelled, intact basement membrane mediated by cellular plasminogen activator. (1982) (60)
Involvement of genotoxic effects in the initiation of estrogen‐induced cellular transformation: Studies using Syrian hamster embryo cells treated with 17β‐estradiol and eight of its metabolites (2000) (60)
Cellular and molecular mechanisms of hormonal carcinogenesis. Environmental influences. (1996) (59)
Deceased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with a carcinogen, diethylstilbestrol. (1986) (59)
Genomic imprinting and environmental disease susceptibility. (2000) (59)
Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA (2019) (58)
Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. (1995) (56)
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. (2009) (54)
Protective effect of pregnancy for development of uterine leiomyoma. (2001) (54)
Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation (2005) (54)
Dependence on exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethylstilbestrol and related compounds. (1984) (54)
Association of p16(INK4a) and pRb inactivation with immortalization of human cells. (2002) (52)
Regulation of apoptosis by low serum in cells of different stages of neoplastic progression: enhanced susceptibility after loss of a senescence gene and decreased susceptibility after loss of a tumor suppressor gene. (1994) (52)
Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signaling. (2005) (51)
Effects of alterations in calcium homeostasis on apoptosis during neoplastic progression. (1997) (51)
A general cloning system to selectively isolate any eukaryotic or prokaryotic genomic region in yeast (2003) (50)
Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines. (2000) (50)
Aligning Tumor Mutational Burden (TMB) quantification across diagnostic platforms: Phase 2 of the Friends of Cancer Research TMB Harmonization Project. (2021) (49)
Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse. (1994) (49)
Closing the gaps on human chromosome 19 revealed genes with a high density of repetitive tandemly arrayed elements. (2004) (48)
Epigenetic mechanisms in human disease. (2002) (48)
Molecular mechanisms of lung cancer. Interaction of environmental and genetic factors. Giles F. Filley Lecture. (1996) (48)
BG-1 ovarian cell line: An alternative model for examining estrogen-dependent growth in vitro (1998) (48)
12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: susceptibility to environmental hazards. (1997) (48)
Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma (1997) (48)
Functional evidence for a telomerase repressor gene on human chromosome 10p15.1 (2001) (47)
Inhibitory effect of complex formation with oligodeoxyribonucleotide ethyl phosphotriesters on transfer ribonucleic acid aminoacylation. (1974) (47)
Down-regulation of cdc2 in senescent human and hamster cells. (1991) (47)
High frequency of carcinogen-induced early, preneoplastic changes in rat tracheal epithelial cells in culture. (1983) (47)
Defining the minimal length of sequence homology required for selective gene isolation by TAR cloning. (2001) (46)
Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. (2005) (46)
Cellular and molecular mechanisms of asbestos carcinogenicity: implications for biopersistence. (1994) (46)
Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen. (2000) (45)
Single gene complementation of the hPMS2 defect in HEC-1-A endometrial carcinoma cells. (1998) (44)
Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. (1994) (44)
Laser capture microdissection, microarrays and the precise definition of a cancer cell (2004) (43)
Differential proliferative responses of Syrian hamster embryo fibroblasts to paraquat-generated superoxide radicals depending on tumor suppressor gene function. (1994) (42)
Role of a tumor-suppressor gene in the negative control of anchorage-independent growth of Syrian hamster cells. (1989) (42)
Role of aneuploidy in early and late stages of neoplastic progression of Syrian hamster embryo cells in culture. (1985) (42)
Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines. (1998) (42)
Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers: Correlative Results from AZD9496 Oral SERD Phase I Trial (2018) (42)
Tumor promoters : biological approaches for mechanistic studies and assay systems (1988) (41)
Reduced Capacitative Calcium Entry Correlates with Vesicle Accumulation and Apoptosis* (1999) (41)
Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. (1999) (41)
A genetic system for direct selection of gene-positive clones during recombinational cloning in yeast. (2002) (41)
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers. (1998) (40)
Cellular senescence in telomerase-expressing Syrian hamster embryo cells. (1998) (40)
Inhibition of tumorigenicity of a murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7. (1994) (40)
Estrogen‐induced cell transformation and DNA adduct formation in cultured Syrian hamster embryo cells (1996) (39)
PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer (2018) (39)
Preneoplastic alterations in nuclear morphology that accompany loss of tumor suppressor phenotype. (1991) (39)
Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells. (1998) (39)
Two posttranscriptional pathways that regulate p21(Cip1/Waf1/Sdi1) are identified by HPV16-E6 interaction and correlate with life span and cellular senescence. (1999) (39)
Failure of senescent cells to phosphorylate the RB protein. (1991) (38)
An integrated transcript map of human chromosome 1p35-p36. (1997) (38)
Molecular modeling of the amino-terminal zinc ring domain of BRCA1. (1996) (38)
Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene (2000) (37)
Selective reduction in receptors for epidermal growth factor-urogastrone in chemically transformed tumorigenic Syrian hamster embryo fibroblasts. (1979) (37)
Prostate cancer — biology of metastasis and its clinical implications (2004) (36)
Aneuploidy induction in human fibroblasts: comparison with results in Syrian hamster fibroblasts. (1990) (36)
Mechanisms of action of known human carcinogens. (1992) (36)
Cell proliferation and chemical carcinogenesis: symposium overview. (1993) (36)
Morphological transformation, DNA damage, and chromosomal aberrations induced by a direct DNA perturbation of synchronized Syrian hamster embryo cells. (1979) (36)
Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based ctDNA Assays: A Joint Consensus Recommendation of the BloodPAC’s Analytical Variables Working Group (2020) (36)
Complete clearance of plasma EGFR mutations as a predictor of outcome on osimertinib in the AURA trial. (2017) (36)
Regulation of apoptosis in uterine leiomyomata. (1997) (36)
Metastasis suppressor genes for prostate cancer (1996) (36)
Disruption of G0-G1 arrest in quiescent and senescent cells treated with phosphatase inhibitors. (1994) (36)
Role of chromosome loss in ras/myc-induced Syrian hamster tumors. (1988) (36)
Chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles. Workshop report. (1996) (35)
Quantitation of fibrinolytic activity of Syrian hamster fibroblasts using 3H-labeled fibrinogen prepared by reductive alkylation. (1977) (35)
Induction of gene mutation in and cell transformation of mammalian cells by modified purines: 2-aminopurine and 6-N-hydroxylaminopurine. (1981) (35)
Ability of peroxisome proliferators to induce cell transformation, chromosome aberrations and peroxisome proliferation in cultured Syrian hamster embryo cells. (1993) (35)
Chromosome aberrations in mouse bone marrow cells following in vivo exposure to 1,3-butadiene. (1987) (34)
Cellular and molecular mechanisms of chemically induced renal carcinogenesis. (1991) (34)
Early clearance of plasma EGFR mutations as a predictor of response to osimertinib and comparator EGFR-TKIs in the FLAURA trial. (2019) (34)
Prostaglandin endoperoxide synthetase-dependent cooxidation of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in C3H/10T 1/2 clone 8 cells. (1982) (34)
The environmental genome project: ethical, legal, and social implications. (2000) (33)
Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response (2020) (33)
The negative association between pre-eclampsia and breast cancer risk may depend on the offspring's gender (2007) (33)
Functional evidence for a metastasis suppressor gene for rat prostate cancer within a 60-kilobase region on human chromosome 8p21-p12. (2002) (33)
Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells. (2005) (32)
Characterization of Distinct Human Endometrial Carcinoma Cell Lines Deficient in Mismatch Repair That Originated from a Single Tumor* (1998) (32)
Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate. (1998) (32)
Mechanisms of estrogen-associated carcinogenesis. (1996) (31)
Melatonin does not inhibit estradiol-stimulated proliferation in MCF-7 and BG-1 cells. (1998) (31)
Role of chemically induced mutagenic events in neoplastic transformation of Syrian hamster embryo cells. (1985) (31)
Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium (2017) (31)
Homozygous deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non-small cell lung cancers. (1995) (31)
BRCA1-mediated repression of select X chromosome genes (2004) (31)
Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2–Brca2 pathway in the homologous recombination‐mediated DNA interstrand cross‐links' repair but does not affect meiosis (2005) (30)
Suppression of tumorigenicity in human ovarian carcinoma cell line SKOV-3 by microcell-mediated transfer of chromosome 11. (2001) (30)
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation (2015) (29)
The fibroid growth study: determinants of therapeutic intervention. (2009) (29)
Induction of neoplastic progression in Syrian hamster embryo cells treated with protein phosphatase inhibitors. (1993) (29)
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8. (1998) (28)
Induction of 6-thioguanine- and ouabain-resistant mutations in synchronized Syrian hamster cell cultures during different periods of the S phase. (1978) (28)
Cell cycle controls: potential targets for chemical carcinogens? (1993) (28)
Functional roles of chromosomes 11 and 17 in the transformation of human breast epithelial cells in vitro. (1999) (28)
Regulation of requirements for anchorage-independent growth of Syrian hamster fibroblasts by somatic mutation (1977) (27)
Hyperplasia of Syrian hamster epidermis induced by single but not multiple treatments with 12-O-tetradecanoylphorbol-13-acetate. (1981) (27)
Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a trade off between quantity and quality? (2016) (27)
Inhibition of terminal differentiation of hamster epidermal cells in culture by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. (1981) (26)
Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic cooperation of V79 Chinese hamster cells. (1983) (26)
Mechanisms of cytotoxicity of asbestos fibres in rat tracheal epithelial cells in culture. (1987) (26)
Role of oncogenes and tumor suppressor genes in a multistep model of carcinogenesis. (1986) (26)
Aflatoxin B1-induced immortalization of cultured skin fibroblasts from a patient with Li-Fraumeni syndrome. (1995) (26)
Pregnancy, parturition, and prostaglandins: defining uterine leiomyomas. (2000) (26)
17β‐Estradiol, diethylstilbestrol, tamoxifen, toremifene and ICI 164,384 induce morphological transformation and aneuploidy in cultured Syrian hamster embryo cells (1997) (26)
Utilization of a fos-lacZ plasmid to investigate the activation of c-fos during cellular senescence and okadaic acid-induced apoptosis. (1994) (25)
Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers (2021) (25)
Vincristine sulfate-induced cell transformation, mitotic inhibition and aneuploidy in cultured Syrian hamster embryo cells. (1986) (24)
The ability of four catechol estrogens of 17beta-estradiol and estrone to induce DNA adducts in Syrian hamster embryo fibroblasts. (2001) (24)
Isolation of a functional copy of the human BRCA1 gene by transformation-associated recombination in yeast. (2000) (24)
Characterization of an unscheduled DNA synthesis assay with Syrian hamster embryo cells. (1984) (23)
Mechanisms for species differences in receptor-mediated carcinogenesis. (1995) (23)
Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system (2002) (23)
p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral neuroepithelioma cell line. (1997) (23)
Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer. (1995) (23)
An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice (2017) (23)
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry (2018) (22)
Clinically Viable Gene Expression Assays with Potential for Predicting Benefit from MEK Inhibitors (2016) (22)
Cell proliferation and chemical carcinogenesis: a symposium overview. (1993) (22)
Melatonin attenuates hydrogen peroxide toxicity in MCF7 cells only at pharmacological concentrations. (1998) (22)
Apoptosis and chemical carcinogenesis. (1994) (22)
Nonrandom karyotypic changes in immortal and tumorigenic Syrian hamster cells induced by diethylstilbestrol. (1989) (22)
Apoptotic response to growth factor deprivation involves cooperative interactions between c-Fos and p300 (2000) (22)
Alteration in diethylstilbestrol-induced mutagenicity and cell transformation by exogenous metabolic activation. (1986) (21)
Morphological characterization of transformed colonies in rat tracheal epithelial cell cultures exposed to carcinogen. (1986) (21)
Reserpine-induced cell transformation without detectable genetic effects in Syrian hamster embryo cells in culture. (1994) (20)
A trivalent dimethylarsenic compound, dimethylarsine iodide, induces cellular transformation, aneuploidy, centrosome abnormality and multipolar spindle formation in Syrian hamster embryo cells. (2004) (20)
STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1 (2020) (20)
Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer. (2000) (20)
Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon (2016) (20)
Cytogenetic changes in rat tracheal epithelial cells during early stages of carcinogen-induced neoplastic progression. (1988) (20)
Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line (2000) (20)
Mutational analysis of the PTEN gene in human uterine sarcomas. (2001) (19)
Identification of genes associated with tumor suppression in Syrian hamster embryo cells. (1991) (19)
Cellular senescence and cancer. (1994) (19)
Complementation of mismatch repair gene defects by chromosome transfer. (1998) (19)
Construction of chicken x human microcell hybrids for human gene targeting. (1997) (19)
Effects of testosterone, testosterone propionate, 17 beta-trenbolone and progesterone on cell transformation and mutagenesis in Syrian hamster embryo cells. (1995) (19)
Resistance to durvalumab and durvalumab plus tremelimumab is associated with functional STK11 mutations in non-small-cell lung cancer patients and is reversed by STAT3 knockdown. (2021) (19)
Dinucleotide repeat polymorphism in the THRA1 gene. (1992) (18)
Elevated expression of mitochondrial cytochrome b and NADH dehydrogenase subunit 4/4L genes in senescent human cells. (1995) (18)
ERCC-1 gene expression levels and outcome to FOLFOX chemotherapy in patients enrolled in CONFIRM1 and CONFIRM2 (2008) (18)
Neoplastic conversion of preneoplastic Syrian hamster cells: rate estimation by fluctuation analysis (1983) (18)
Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. (1994) (18)
Amitrole-induced cell transformation and gene mutations in Syrian hamster embryo cells in culture. (1984) (17)
Identification of CCR2 and CD180 as Robust Pharmacodynamic Tumor and Blood Biomarkers for Clinical Use with BRD4/BET Inhibitors (2017) (17)
Cell‐transforming activity and genotoxicity of phenolphthalein in cultured Syrian hamster embryo cells (1997) (17)
Immortal, telomerase-negative cell lines derived from a Li-Fraumeni syndrome patient exhibit telomere length variability and chromosomal and minisatellite instabilities. (2003) (17)
Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma (2020) (17)
15 – Mechanistic Studies of Neoplastic Transformation of Cells in Culture (1978) (17)
Expression of Gab1 Lacking the Pleckstrin Homology Domain Is Associated with Neoplastic Progression (2001) (17)
Analysis of growth fractions and stem cell compartments in transformed rat tracheal epithelial cell colonies. (1986) (16)
Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown (2021) (16)
Elevated ceramide is downstream of altered calcium homeostasis in low serum-induced apoptosis. (2000) (16)
Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q. (1996) (16)
Double nondisjunction during karyotypic progression of chemically induced Syrian hamster cell lines. (1985) (16)
Quantitation of cell proliferation, colony formation, and carcinogen induced cytotoxicity of rat tracheal epithelial cells grown in culture on 3T3 feeder layers (1983) (16)
Exploratory biomarker analysis of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors. (2014) (15)
The effect of 12-O-tetradecanoylphorbol-13-acetate and other tumor promoters on the colony formation of rat tracheal epithelial cells in culture. (1984) (15)
Comparison between mutagenesis in normal and transformed Syrian hamster fibroblasts: difference in the temporal order of HPRT gene replication. (1981) (15)
Reexamination of the role of plasminogen activator production for growth in semisolid agar of neoplastic hamster cells. (1980) (15)
Expression of a fms-related oncogene in carcinogen-induced neoplastic epithelial cells. (1987) (15)
Changing responsiveness to all-trans retinoic acid of rat tracheal epithelial cells at different stages of neoplastic transformation. (1986) (14)
Proliferation Tumour Marker Network (PTM-NET) for the identification of tumour region in Ki67 stained breast cancer whole slide images (2019) (14)
In vitro analysis of multistage carcinogenesis. (1987) (14)
Cytogenetic analysis of murine cell lines from diethylstilbestrol-induced uterine endometrial adenocarcinomas. (1994) (14)
Inhibition of transformation of primary rat tracheal epithelial cells by retinoic acid. (1984) (14)
Mutations and altered expression of the human cancer genes: what they tell us about causes. (1999) (14)
Studies on Why 12-0-Tetradecanoyl-Phorbol-13-Acetate (TPA) Does Not Promote Epidermal Carcinogenesis of Hamsters (1980) (13)
Effects of TCDD upon IκB and IKK subunits localized in microsomes by proteomics (2002) (13)
Hormonal carcinogenesis and environmental influences: background and overview. (1996) (13)
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum. (2017) (13)
HETEROCYCLIC PHOTOCHEMISTRY. 1. PHOTOTRANSPOSITIONS IN HYDROXYPYRYLIUM CATIONS. PERMUTATION PATTERN ANALYSIS AND MECHANISTIC STUDIES (1979) (13)
Failure of HPV E6 to rapidly degrade p53 in human HeLa×PNET cell hybrids (1997) (13)
Changes in stem cell populations of rat tracheal epithelial cell cultures at an early stage in neoplastic progression. (1985) (13)
Measurement of spontaneous mutation rates at the Na+/K+ ATPase locus (ouabain resistance) of human fibroblasts using improved growth conditions. (1982) (13)
Quantitation of the rate of spontaneous generation and carcinogen-induced frequency of anchorage-independent variants of rat tracheal epithelial cells in culture. (1985) (13)
Mechanisms of Acquired Resistance to Savolitinib, a Selective MET Inhibitor in MET-Amplified Gastric Cancer (2020) (13)
cDNA Cloning of the Human Polybromo-1 Gene on Chromosome 3p21 (2002) (12)
Neoplastic transformation of normal and carcinogen-induced preneoplastic Syrian hamster embryo cells by the v-src oncogene (1985) (12)
The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association. (1999) (12)
Abstract 2398: Activity of the PARP inhibitor olaparib in ATM-deficient gastric cancer: from preclinical models to the clinic (2014) (12)
Prioritisation of structural variant calls in cancer genomes (2016) (12)
Use of intratumoral mRNA expression of genes involved in angiogenesis and HIF1 pathway to predict outcome to VEGFR tyrosine kinase inhibitor (TKI) in patients enrolled in CONFIRM1 and CONFIRM2 (2008) (11)
Induction by modified purines (2-aminopurine and 6-N-hydroxylaminopurine) of chromosome aberrations and aneuploidy in Syrian hamster embryo cells. (1985) (11)
Establishment and characterization of a breast cell strain containing a BRCA1 185delAG mutation. (2000) (11)
Evidence-based laboratory medicine in oncology drug development: from biomarkers to diagnostics. (2013) (11)
Comparison of human versus Syrian hamster cells in culture for induction of mitotic inhibition, binucleation and multinucleation, following treatment with four aneuploidogens. (1990) (11)
Expression of KAI1 in paraffin‐embedded normal, hyperplastic and neoplastic prostate and prostate carcinoma cell lines (1998) (11)
Sodium bisulfite induces morphological transformation of cultured Syrian hamster embryo cells but lacks the ability to induce detectable gene mutations, chromosome mutations or DNA damage. (1990) (11)
EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of technologies to support the clinical development of AZD9291. (2014) (11)
Genetic and molecular basis for cellular senescence. (1993) (11)
Activation of cellular oncogenes by chemical carcinogens in Syrian hamster embryo fibroblasts. (1990) (11)
Differential response to retinoic acid of Syrian hamster embryo fibroblasts expressing v-src or v-Ha-ras oncogenes (1986) (11)
Rescue of targeted regions of mammalian chromosomes by in vivo recombination in yeast. (1998) (10)
Validation of ctDNA Quality Control Materials Through a Precompetitive Collaboration of the Foundation for the National Institutes of Health (2021) (10)
Are companion diagnostics useful? (2013) (10)
Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets (2022) (10)
Cytotoxicity and chromosome aberrations in normal human oral keratinocytes induced by chemical carcinogens: Comparison of inter-individual variations. (1991) (10)
Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression. (2001) (10)
Degradation of type IV collagen by neoplastic human skin fibroblasts. (1985) (10)
Mechanisms of human carcinogens. (1992) (10)
Cellular and molecular mechanisms of hormonal carcinogenesis (1996) (9)
Interference of proteins involved in the cytoplasmic sequestration of p53 with human papillomavirus E6–mediated degradation (1999) (9)
Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum (2017) (9)
Regulation of hTERT transcription: a target of cellular and viral mechanisms for immortalization and carcinogenesis (2004) (9)
Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens. (1993) (9)
Cellular Senescence Mechanisms Independent of Telomere Shortening and Telomerase: Other Barriers to Cell Immortalization and Carcinogenesis (2000) (9)
Suppression of metastasis of rat prostate cancer by introduction of human chromosome 13. (2002) (9)
2,3,7,8-Tetrachlorodibenzo-p-dioxin enhancement of N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation of rat tracheal epithelial cells in culture. (1989) (9)
Human chromosome II inhibits tumorigenicity of a murine squamous cell carcinoma cell line (1995) (9)
A Quantitative, Clonal Assay for Carcinogen-Induced Alterations of Respiratory Epithelial Cells in Culture (1983) (9)
Erratum: Regulation of apoptosis in uterine leiomyomata (Endocrinology (1997) 138 (3056-3064)) (1997) (8)
Identification of a ≦600-kb region on human chromosome 1q42.3 inducing cellular senescence (2003) (8)
Olaparib plus paclitaxel sensitivity in biomarker subgroups of gastric cancer. (2018) (8)
Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD. (2021) (8)
Hypermethylation of the p 16 Ink 4 a promoter in B 6 C 3 F 1 mouse primary lung adenocarcinomas and mouse lung cell lines (2000) (8)
A National Institutes of Health Workshop Report. Cellular and molecular mechanisms for suppression and reversion of tumorigenicity. A Chemical Pathology Study Section workshop. (1987) (8)
A Phase Ib, Open-Label, Multi-Center Study to Assess the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of AZD1775 Monotherapy in Patients with Advanced Solid Tumors: Expansion Cohorts. (2016) (8)
Cell culture models of multistep carcinogenesis. (1985) (8)
Deacylation of 12-O-[3H]tetradecanoylphorbol-13-acetate and [3H]phorbol-12,13-didecanoate in hamster skin and hamster cells in culture. (1982) (8)
Plasminogen activator in metastasis (1982) (8)
Molecular landscape of osimertinib resistance revealed by targeted panel sequencing and patient-derived cancer models in non-small cell lung cancer patients. (2018) (8)
Molecular carcinogenesis in humans and rodents. (1992) (8)
Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer (2021) (8)
Use of quantitative cell transformation assays in risk estimation (1985) (8)
Wild-type p53 is not involved in reversion of the tumorigenic phenotype of breast-cancer cells after transfer of normal chromosome-17. (1994) (8)
Pharmacodynamic activity of the AKT inhibitor AZD5363 in patients with advanced solid tumors. (2014) (7)
Coordinate regulation of collagen II(alpha 1) and H19 expression in immortalized hamster cells. (1993) (7)
Negative regulation of mitogen‐stimulated, anchorage‐independent cell growth by a tumor‐suppressor gene function (1993) (7)
Abstract PD6-01: Novel approach to HER2 quantification: Digital pathology coupled with AI-based image and data analysis delivers objective and quantitative HER2 expression analysis for enrichment of responders to trastuzumab deruxtecan (T-DXd; DS-8201), specifically in HER2-low patients (2021) (7)
Pregnancy and protection from hormonally associated tumor development. (2003) (7)
Mechanisms of multistep carcinogenesis: keys to developing in vitro approaches for assessing the carcinogenicity of chemicals. (1986) (7)
Dose-response studies of nickel-induced morphological transformation of Syrian hamster embryo fibroblasts. (1988) (7)
Mouse retroviral sequences acquired by cell lines after passaging through nude mice detected by hybridization of the fms probe pSM3. (1989) (7)
Correlation of V-src gene amplification with the tumorigenic phenotype in a Syrian hamster embryo cell line. (1987) (7)
Hypotheses on the Mechanisms of Carcinogenesis and Cell Transformation by Asbestos and Other Mineral Dusts (1990) (6)
Abstract 4897: Detection of MET-mediated EGFR tyrosine kinase inhibitor (TKI) resistance in advanced non-small cell lung cancer (NSCLC): biomarker analysis of the TATTON study (2019) (6)
Changes in expression of imprinted genes following treatment of human cancer cell lines with non-mutagenic or mutagenic carcinogens. (2008) (6)
Linking laboratory and clinical research: the development of molecularly targeted therapeutics inside the national cancer institute center for cancer research. (2003) (6)
Is target validation all we need? (2014) (6)
MOLECULAR AND ENVIRONMENTAL CAUSES OF CANCER (2000) (6)
Toxicity of Asbestos and Glass Fibers for Rat Tracheal Epithelial Cells in Culture (1985) (6)
In vitro transformation of rat tracheal epithelial cells: a model for the study of multistage carcinogenesis. (1985) (6)
Analysis of tumour samples from SOLO1: Frequency of BRCA specific loss of heterozygosity (LOH) and progression-free survival (PFS) according to homologous recombination repair deficiency (HRD)-LOH score (2019) (6)
Detection of multiple tumor suppressor genes for Syrian hamster fibrosarcomas by somatic cell hybridization (1992) (6)
Short-term assays to predict carcinogenicity. In-vitro assays that may be predictive of tumour-promoting agents. (1986) (6)
The pharmacodynamic effect of TKI258 on plasma biomarkers of angiogenesis in patients with AML and advanced melanoma (2008) (5)
Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response (2021) (5)
The progressive nature of neoplastic transformation of Syrian hamster embryo cells in culture. (1979) (5)
Concordance of BRCA mutation detection in tumor versus blood, and frequency of bi-allelic loss of BRCA in tumors from patients in the phase III SOLO2 trial. (2021) (5)
Abstract 5671: Alignment of TMB measured on clinical samples: Phase IIB of the Friends of Cancer Research TMB Harmonization Project (2020) (5)
Inactivation of a tumor suppressor function in immortal Syrian hamster cells by N-methyl-N'-nitro-N-nitrosoguanidine and by 5-aza-2'-deoxycytidine. (1993) (5)
Human chromosome 11 inhibits tumorigenicity of a murine squamous cell carcinoma cell line. (1995) (5)
Fibroblast growth factor receptor 3 (FGFR3) mutant muscle invasive bladder cancers (MIBC) are associated with low immune infiltrates (2016) (4)
The toxic response of preneoplastic rat tracheal epithelial cells to 12-O-tetradecanoylphorbol-13-acetate. (1985) (4)
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance (2022) (4)
Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging (1991) (4)
Multiple human chromosomes carrying tumor‐suppressor functions for the mouse melanoma cell line B16‐F10, identified by microcell‐mediated chromosome transfer (2002) (4)
Analysis of candidate homologous repair deficiency genes in a clinical trial of olaparib in patients (pts) with platinum-sensitive, relapsed serous ovarian cancer (PSR SOC). (2014) (4)
T-cell receptor pharmacodynamics associated with survival and response to tremelimumab (T) in combination with durvalumab (D) in patients (pts) with unresectable hepatocellular carcinoma (uHCC). (2021) (3)
Abstract 611: Exploratory analyses suggest ovarian tumors with somatic or germline loss of function mutations inBRCA1orBRCA2are biologically similar and sensitive to PARP inhibition (2015) (3)
HOXB13 May Predict Response to Neoadjuvant Letrozole in Patients with Estrogen Receptor-Positive Breast Cancer. (2009) (3)
Abstract LB-249: Examination of analytical factors impacting concordance of plasma-tumor testing by next-generation sequencing (NGS) (2017) (3)
Development, Validation, and Regulatory Considerations for a Liquid Biopsy Test. (2020) (3)
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis. (2021) (3)
Multistage neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells by viral oncogenes. (1985) (3)
Neoplastic Progression of Syrian Hamster Embryo Cells in Culture (1993) (3)
Mechanisms of metastasis suppression by introduction of human chromosome 10 into rat prostate cancer. (2002) (3)
Involvement of Radicals in Chemical Carcinogenesis (1976) (3)
Genomic characterization of long-term responders to olaparib. (2015) (3)
Locus-specific loss of heterozygosity (LOH) in BRCA1/2 mutated (mBRCA) ovarian tumors from the SOLO2 (NCT01874353) and Study 19 (NCT00753545) clinical trials. (2018) (3)
Multiomic Characterization of High-Grade Serous Ovarian Carcinoma Enables High-Resolution Patient Stratification (2022) (3)
pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry (2018) (3)
Complementation of a DNA repair deficiency in six human tumor cell lines by chromosome 11 (1992) (3)
Short-term assays to predict carcinogenicity. Mammalian cell transformation in culture. (1986) (3)
Candidate predictive biomarkers for response to olaparib in advanced gastric cancer (AGC). (2016) (3)
Analysis of BRCA genes and homologous recombination deficiency (HRD) scores in tumours from patients (pts) with metastatic breast cancer (mBC) in the OlympiAD trial (2019) (3)
Asbestos Carcinogenicity: A Mutational Hypothesis (1991) (2)
Serial monitoring of genomic alterations in circulating tumor cells of ER‐positive/HER2‐negative advanced breast cancer: feasibility of precision oncology biomarker detection (2021) (2)
The RB gene locates on chromosome 15 at band 15q13 in the Syrian hamster. (1994) (2)
Characterization of murine cell lines from Diethylstilbestrol-Induced uterine endometrial Adenocarcinomas (1992) (2)
Abstract 4541:METgene copy number gains evaluated by NGS is more predictive than other methods to enrich for papillary RCC patients sensitive to savolitinib, a selective MET inhibitor (2018) (2)
Introduction of new genetic markers on human chromosomes. (1991) (2)
Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound (2022) (2)
Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial (2023) (2)
Correction of mismatch repair defective lines via chromosome transfer (1996) (2)
Intracellular Translocation of Inorganic Particles (1986) (2)
Longterm survival of normal, diploid Syrian hamster-cells in tumors induced by transfection with v-Ha-ras and v-myc oncogenes. (1989) (2)
Acquired EGFR C 797 S mediates resistance to AZD 9291 in advanced non-small cell lung cancer harboring EGFR T 790 M (2016) (2)
Role of Arachidonic and Linoleic Acid Metabolites in Growth Regulation of Syrian Hamster Embryo Fibroblasts: Studies with Tumor Suppressor Gene (+) and Suppressor Gene (-) Phenotypes (1991) (2)
Antitumor activity of the WEE1 inhibitor AZD1775 as a monotherapy and in combination with the PARP inhibitor olaparib in patient-derived explant (PDX) models (2016) (2)
Studies on the action of tumour promoters and antipromoters on respiratory-tract epithelium. (1984) (2)
The Molecular Genetics of Endometrial Cancer (2005) (2)
Environmental causes and molecular biology of breast cancer: future research directions. (1996) (2)
Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes (2018) (1)
TOXICOLOGICAL HIGHLIGHT Gene Expression Analysis Reveals Chemical-Specific Profiles (2002) (1)
Plasma biomarker analysis of a phase I trial of ASA404 (vadimezan) in combination with paclitaxel and carboplatin in Japanese patients with non-small cell lung cancer (NSCLC). (2010) (1)
Clinical performance of a comprehensive novel liquid biopsy test for identifying non-small cell lung cancer (NSCLC) patients for treatment with osimertinib. (2020) (1)
Pathways of Aberrant Signaling Microsatellite Stable Endometrial Cancers Indicates Distinct Gene Expression Profiling of Microsatellite Unstable and Updated (2005) (1)
Detecting T cell receptor rearrangements in silico from non-targeted DNA-sequencing (WGS/WES) (2017) (1)
17beta-estradiol, diethylstilbestrol, tamoxifen, toremifene and ICI 164,384 induce morphological transformation and aneuploidy in cultured Syrian hamster embryo cells. (1997) (1)
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition (2022) (1)
Programmed death-ligand 1 (PD-L1) and immune infiltrates are prognostic for better outcome and enriched in the ATM (ataxia telangiectasia mutated)-low segment of gastric cancer (GC) (2016) (1)
Analysis of tumor samples from SOLO2: Concordance of BRCA mutation (BRCAm) detection in tumor vs. blood and frequency of BRCA-specific loss of heterozygosity (LOH) and loss of function somatic mutations. (2018) (1)
Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation (2014) (1)
Introduction of a normal chromosorne 8 into Werner syndrome cells by microcell fusion (1993) (1)
Multimodal detection of homologous recombination repair gene mutations (HRRm) in a phase II trial of olaparib plus abiraterone in metastatic castrate resistant prostate cancer (mCRPC). (2018) (1)
Gene expression analysis in human hair bulbs as a potential pharmacodynamic readout in the LDE225 clinical program. (2010) (1)
Identification of a gene signature that can predict lone-term survival in patients with high-grade late stage serous ovarian cancer (2005) (1)
The Role of hMLHl, HMSH3, and HMSH6 Defects in Cisplatin and Oxaliplatin Resistance: Correlation with Replicative Bypass of Platinum-DNA Adducts1 (2006) (1)
Library of human chromosomes in mouse cells for mapping genes by function. (1994) (1)
Genetic determinants in carcinogenesis. (1993) (1)
Role of tumor suppressor genes in a multistep model of carcinogenesis. (1991) (1)
Differential growth control of normal, preneoplastic and neoplastic Syrian hamster embryo cells in serum-free media. (1993) (1)
Cellular Senescence and the Cell Cycle (1994) (1)
Abstract 749: Multi-layer molecular characterization of high grade serous ovarian carcinomas (2019) (1)
CALIBRATE: Intensive profiling of circulating tumour DNA (ctDNA) from patients participating in experimental therapeutics trials including mutational profiles and copy number changes. (2016) (0)
Abstract 337: Genetic analysis of tumors from a phase II trial evaluating AZD1775, carboplatin and paclitaxel in patients with TP53-mutant ovarian cancer (2016) (0)
Neoplastic transformaiton of mesothelial cells (1994) (0)
CANCER AND AGING IN RODENTS VERSUS HUMANS (1992) (0)
Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response (2019) (0)
Perspectives in Cancer Research Gap Junction Function and Cancer (2006) (0)
Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors (2023) (0)
Immunologically relevant gene expression as prognostic biomarker in squamous cell carcinoma of the head and neck. (2017) (0)
S32 01 FA – TUMOR SUPPRESSOR GENES, CELLULAR SENESCENCE, AND MULTISTEP CARCINOGENESIS (1991) (0)
Molecular Genetic Profiles of Serous and Endometrioid Endometrial Cancers, Genes Downregulated in Endometrial Cancers, and the Role of Epigenetics (2003) (0)
Abstract 3310: Human artificial chromosome (HAC) vector with a conditional centromere for correction of human genetic deficiencies. (2013) (0)
Abstract LB-123: Analysis of cell-free plasma DNA (cfDNA) identifies 3 molecular subtypes of acquired resistance to AZD9291, a novel EGFR tyrosine kinase inhibitor (TKI), in patients (pts) with advanced lung cancer (2015) (0)
1. Cell cycle regulation and cellular senescence (1992) (0)
Association of TS and ERCC1 mRNA expressions with overall survival in patients enrolled in CONFIRM 1 and 2. (2010) (0)
Automatic carbon monoxide monitor. (1966) (0)
Relationship between somatic mutation and neoplastic transformation ( chemical carcinogenesis / Syrian hamster / anchorage independence / morphological transformation / neoplastic progression ) (0)
Combination of functional genomics approaches and microarray analyses to define candidate senescence genes (2001) (0)
The altered expression of Gab1 during neoplastic progression: A possible regulator of the altered responsiveness to growth factors and lipid mediators (1999) (0)
Response to savolitinib (AZD6094/HMPL-504, a potent and selective MET inhibitor) in a papillary renal cell carcinoma patient harbouring a novel MET activating mutation (2016) (0)
Gene Expression Profiles of Serous , Endometrioid , and Clear Cell Subtypes ofOvarianand Endometrial Cancer (2005) (0)
Cloning of genes involved in cancer progression by a combination of functional and positional cloning (1997) (0)
Comparison of the growth and differentiation of normal and diethylnitrosamine (DEN) exposed hamster tracheal epithelial (HTE) cells in culture (1982) (0)
Abstract A63: Examination of ctDNA false positive variants reported from commercial vendors by ultrasensitive orthogonal testing (2020) (0)
Possibility of DHFR Gene Amplification by Arsenic (1993) (0)
A GeneInvolved inControl ofHumanCellular Senescence on HumanChromosome lq (1994) (0)
Abstract 5095: Development of a pharmacodynamic biomarker assay for AZD4785, an antisense oligonucleotide targeting KRAS (2017) (0)
Prostaglandin synthetase dependent oxidation of (+)trans7,9-dihydroxy- -7,8-dihydro-benzo(a)pyrene to mutagenic metabolites in c3h/10t1/2 cells. Abstr. (1981) (0)
Morphological Transformation, DNADamage,and ChromosomalAberrations Induced by a Direct DNAPerturbation of SynchronizedSyrian Hamster Embryo Celli' (1979) (0)
Book Review:Molecular and Cellular Aspects of Carcinogen Screening Tests. R. Montesano, H. Bartsch, L. Tomatis (1981) (0)
Abstract A48: Tissue cytometry platform for quantitating multiple signaling pathways proteins in intact tissue sections (2009) (0)
Novel Mechanisms of Acalabrutinib Resistance in Patients with Chronic Lymphocytic Leukemia By Whole Genome Methylome Sequencing (2021) (0)
Correlation of circulating tumor DNA (ctDNA), tissue-based genomic profiling and clinical efficacy in the biomarker directed Ph1b trial in metastatic bladder cancer (BISCAY). (2019) (0)
Development and Use of Clinical Pharmacodynamic Assays to Demonstrate Target Engagement for AZD4573, a Selective and Potent CDK9 Inhibitor Currently in Phase I Clinical Trials (2018) (0)
transformed cells - HTLV-I B pathway in κ Transcriptional activation of hTERT through the NF- (2013) (0)
Abstract 5427: Genomic prevalence analysis in TNBC patients in the Phase 2 VIOLETTE study (2020) (0)
Toxicant identification and classiacation using cDNA microarray technology (1998) (0)
Prediction of Lymph NodeMetastasis in Patientswith Endometrioid Endometrial Cancer Using ExpressionMicroarray (2005) (0)
Summary and Synthesis of Part III. Carcinogenicity and Related Genotoxic Events (1985) (0)
8LBA Activity of the PARP inhibitor olaparib in ATM-deficient gastric cancer: from preclinical models to the clinic (2014) (0)
Abstract 3215: STAT3 antisense oligonucleotide (ASO) reverses immunosuppression and enhances cytotoxic cell function to enhance PDL1 blockade (2019) (0)
Abstract 3375: Normal viability of Kai1/CD82 deficient mice (2010) (0)
Advances in Brief Chromosome 5 Suppresses Tumorigenicity of PC 3 Prostate Cancer Cells : Correlation with Re-Expression of a-Catenin and Restoration of E-Cadherin Function 1 (2006) (0)
Abstract 150: Identification of determinants of sensitivity to AKT inhibition using breast cancer (BC) patient-derived tumor xenografts (PDX) (2017) (0)
Modulation of Transforming and Clastogenic Activities of Catechol Estrogens by a Catechol-O-methyltransferase Inhibitor in Syrian Hamster Embryo Fibroblasts (2005) (0)
M30 and M65 assessments demonstrate pro-apoptotic effect of LBY135, a monoclonal antibody agonist to DR5 (2008) (0)
Cellular Transforming Activity and Genotoxic Effects of 17β- Estradiol and its Eight Metabolites in Syrian Hamster Embryo Cells (2001) (0)
Abstract C196: EGFR mutation detection in ctDNA isolated from NSCLC patient plasma; a cross-platform comparison of leading technologies. (2013) (0)
Cellular and Molecular Mechanisms of Asbestos Carcinogenicity: Implications for (2016) (0)
Polymorphisms 17 q in Sporadic Breast Carcinoma Using Microsatellite Length Detection of Frequent Allelic Loss on Proximal Chromosome (2006) (0)
Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. (1980) (0)
Abstract 1706: Whole exome sequencing of pre and post treatment diffuse large B cell lymphoma reveals the mutation spectrum of the relapse/refractory patient population (2015) (0)
Proliferation of anti-proliferation factors. (1990) (0)
Tumor suppressor gene penetrance determined by early life environmental exposure (2004) (0)
Progression-specific markers in breast cancer obtained by microarray analysis are located to the malignant epithelial tumor cells (2006) (0)
Abstract 5582: Use of circulating tumor DNA (ctDNA) to predict superiority of dosing schedules in early clinical development (2018) (0)
Expression profiling of microdissected papillary serous ovarian epithelial cancers identifies genes describing the unique phenotypes of borderline and malignant tumors (2005) (0)
2,3,7,8-Tetrachlorodibenzo-p-dioxinEnhancement of TV-Methyl-W-nitro-W- nitrosoguanidine-inducedTransformation of Rat TrachÃ©al Epithelial Cells in Culture (1989) (0)
Abstract LB-110: Expression of multiple androgen receptor splice variants in late stage prostate cancer (2015) (0)
Advances in Brief Single Gene Complementation of the HPMS 2 Defect in HEC-l-A Endometrial Carcinoma Cells (2006) (0)
Cell Transformation: State of the Art (1985) (0)
Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer (2019) (0)
Abstract 4582: Capturing T cell receptor clones from circulating free DNA in cancer patients with solid malignancies (2018) (0)
Expression of a fms-related oncoge neoplastic epithelial cells (chemical transformation/growth factor receptors/neoplastic progre (2016) (0)
Treatment with aflatoxin B1 for immortalization of human fibroblasts from Li-Fraumeni patients (1995) (0)
Successes and challenges faced by tissue collection during trials by oncology translational sciences. (2018) (0)
Treated with Phosphatase Inhibitors Arrest in Quiescent and Senescent Cells 1G 0 Disruption of G Updated (2006) (0)
Advances in Brief Functional Evidence for a Metastasis Suppressor Gene for Rat Prostate Cancer within a 60-Kilobase Region on Human Chromosome 8 p 21p 121 (2002) (0)
Contrasting responses of normal and transformed rat tracheal epithelial cells to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. (1985) (0)
The Role of hMLHl , HMSH 3 , and HMSH 6 Defects in Cisplatin and Oxaliplatin Resistance : Correlation with Replicative Bypass of Platinum-DNA Adducts 1 (2006) (0)
Abstract B55: Exploratory biomarker analyses of tumor and peripheral blood samples from the phase I durvalumab plus gefitinib trial in EGFR-mutated NSCLC (2020) (0)

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