Johnxs C. Hutton
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Genetics
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Molecular Biology
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Biology
Johnxs C. Hutton's Degrees
- PhD Genetics Stanford University
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(Suggest an Edit or Addition)Johnxs C. Hutton's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene (1997) (1073)
- The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes (2007) (941)
- Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice (2005) (752)
- Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases (1988) (347)
- Insulin release: the fuel hypothesis. (1979) (335)
- Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. (2003) (313)
- Molecular Cloning of Phogrin, a Protein-tyrosine Phosphatase Homologue Localized to Insulin Secretory Granule Membranes* (1996) (235)
- Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. (1999) (229)
- T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins (1990) (214)
- Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. (2006) (200)
- A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes (2008) (198)
- The stimulus-secretion coupling of glucose-induced insulin release (1979) (188)
- Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. (2009) (176)
- Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. (1983) (172)
- In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. (1995) (169)
- Age of Islet Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes (2011) (168)
- Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes (2010) (158)
- The internal pH and membrane potential of the insulin-secretory granule. (1982) (142)
- Diminished β-cell replication contributes to reduced β-cell mass in fetal sheep with intrauterine growth restriction (2005) (141)
- Glucose-6-phosphatase Catalytic Subunit Gene Family* (2009) (138)
- Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera. (1998) (133)
- The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. (1987) (133)
- Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. (1992) (131)
- The insulin secretory granule (1989) (129)
- Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell. (2000) (128)
- REGULATION OF CALCIUM FLUXES AND THEIR REGULATORY ROLES IN PANCREATIC ISLETS * (1978) (120)
- T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes (1991) (119)
- The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. (1978) (119)
- The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. (1978) (118)
- A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. (1992) (113)
- Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. (1999) (109)
- Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. (1989) (107)
- Dense Core Vesicle Dynamics in Caenorhabditis elegans Neurons and the Role of Kinesin UNC‐104 (2004) (107)
- Global gene expression profiling and histochemical analysis of the developing human fetal pancreas (2008) (104)
- Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. (2011) (104)
- SlC30A8 Is a Major Target of Humoral Autoimmunity in Type 1 Diabetes and a Predictive Marker in Prediabetes (2008) (103)
- On the Pathogenicity of Autoantigen-Specific T-Cell Receptors (2008) (102)
- Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release. (1980) (100)
- Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. (2001) (100)
- Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases (1994) (97)
- Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line (2009) (94)
- Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10). (1987) (94)
- Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. (1996) (93)
- Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies (2012) (93)
- The Stimulus-secretion Coupling of Amino Acid-induced Insulin Release: Metabolism and Cationic Effects of Leucine (1980) (93)
- The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese (2010) (92)
- Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. (2002) (89)
- Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials (2010) (87)
- Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins. (1991) (85)
- Induction of Indoleamine 2,3-Dioxygenase by Interferon-γ in Human Islets (2007) (85)
- Carboxypeptidase activity in the insulin secretory granule (1983) (84)
- Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme. (1989) (84)
- Novel Diabetes Autoantibodies and Prediction of Type 1 Diabetes (2013) (83)
- Identification of the 37-kDa Antigen in IDDM as a Tyrosine Phosphatase-Like Protein (Phogrin) Related to IA-2 (1996) (83)
- Cytokine-mediated Down-regulation of the Transcription Factor cAMP-response Element-binding Protein in Pancreatic β-Cells* (2003) (81)
- T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM (1995) (80)
- Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8 (2011) (80)
- Contribution of Antibodies Against IA-2β and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age (2011) (79)
- Cloning and Characterization of the Human and Rat Islet-specific Glucose-6-phosphatase Catalytic Subunit-related Protein (IGRP) Genes* (2001) (79)
- IDA‐1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA‐2 and phogrin, is expressed in peptidergic neurons in the worm (2001) (76)
- The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background (2012) (73)
- Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes (2008) (72)
- Cathepsin B-related proteases in the insulin secretory granule. (1984) (71)
- Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. (2010) (70)
- Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. (1998) (70)
- Dynamics of O2 consumption in rat pancreatic islets (1980) (69)
- The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets. (1981) (68)
- The molecular cloning of the chromogranin A‐like precursor of β‐granin and pancreastatin from the endocrine pancreas (1988) (68)
- Identification of the Region within the Neuroendocrine Polypeptide 7B2 Responsible for the Inhibition of Prohormone Convertase PC2 (*) (1995) (67)
- Novel antigens in type 1 diabetes: The importance of ZnT8 (2009) (67)
- Identification of a Transferable Sorting Domain for the Regulated Pathway in the Prohormone Convertase PC2* (1996) (67)
- The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2. (1994) (65)
- Biosynthesis of betagranin in pancreatic beta-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin. (1987) (64)
- Molecular and cellular regulation of prohormone processing. (1998) (64)
- Interaction of branched chain amino acids and keto acids upon pancreatic islet metabolism and insulin secretion. (1980) (62)
- Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype (2007) (61)
- Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway. (1990) (61)
- The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. (1979) (61)
- G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion (2013) (59)
- The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. (1978) (58)
- Autoantibodies to Protein Tyrosine Phosphatase-Like Proteins In Type I Diabetes: Overlapping Specificities To Phogrin And ICA512/IA-2 (1996) (58)
- Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. (2003) (58)
- β‐Granins: 21 kDa co‐secreted peptides of the insulin granule closely related to adrenal medullary chromogranin A (1985) (58)
- Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets. (1979) (57)
- Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. (2006) (56)
- Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell. (1997) (55)
- Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules. (1982) (55)
- Peptide Hormone Action: A Practical Approach (1991) (54)
- The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. (1992) (54)
- Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. (1996) (53)
- Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients (2012) (53)
- A pancreatic β-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes (2003) (52)
- Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue. (1993) (52)
- Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. (2005) (51)
- Argyrophilia and Granin (Chromogranin/Secretogranin) Expression in Female Breast Carcinomas Their Relationship to Survival and Other Disease Parameters (1992) (50)
- The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets. (1978) (50)
- Localization of pancreastatin immunoreactivity in porcine endocrine cells. (1988) (48)
- Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. (1987) (48)
- Immunolocalization of betagranin: a chromogranin A-related protein of the pancreatic B-cell. (1988) (48)
- Recycling of the dense-core vesicle membrane protein phogrin in Min6 β-cells (2004) (46)
- ETS‐family genes in pancreatic development (2007) (46)
- T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. (1995) (46)
- Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach (2001) (45)
- Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas (2006) (45)
- Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. (1991) (43)
- Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells (1995) (43)
- Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. (2007) (43)
- Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes (2011) (43)
- Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas–Kidney Transplants (2015) (43)
- Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma. (1984) (42)
- Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost‐effective and age‐independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients (2013) (42)
- Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases (2012) (41)
- The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration. (1980) (40)
- The tissue distribution of rat chromogranin A-derived peptides: evidence for differential tissue processing from sequence specific antisera (2004) (39)
- Identification of a Major Humoral Epitope in Slc30A8 (ZnT8) (2008) (38)
- A phogrin-aequorin chimaera to image free Ca2+ in the vicinity of secretory granules. (1998) (38)
- Isolation and characterisation of insulin secretory granules from a rat islet cell tumour (1982) (37)
- Proinsulin processing in the diabetic Goto-Kakizaki rat. (2002) (36)
- Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. (1999) (36)
- The Lumenal Domain of the Integral Membrane Protein Phogrin Mediates Targeting to Secretory Granules (2002) (36)
- T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient. (1996) (36)
- Production and characterization of monoclonal antibodies to insulin secretory granule membranes. (1987) (36)
- Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse (2008) (36)
- Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets (2007) (36)
- The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. (2011) (35)
- Peptide hormone secretion : a practical approach (1990) (34)
- Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin. (1989) (34)
- Proprotein-processing endopeptidases of the insulin secretory granule. (1991) (34)
- HLA-DQ8-Associated T Cell Responses to the Diabetes Autoantigen Phogrin (IA-2β) in Human Prediabetes1 (2004) (33)
- Biosynthesis of insulin secretory granule membrane proteins. Control by glucose. (1987) (33)
- Calcium-binding proteins and secretion. (1986) (33)
- An Extended Tyrosine‐Targeting Motif for Endocytosis and Recycling of the Dense‐Core Vesicle Membrane Protein Phogrin (2005) (32)
- The stimulus-secretion coupling of amino acid-induced insulin release. Synergistic effects of L-glutamine and 2-keto acids upon insulin secretion. (1981) (31)
- Protein Tyrosine Phosphatase-Like Proteins: Link With IDDM (1997) (31)
- Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes (2000) (30)
- Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue. (1999) (30)
- New antigenic targets in type 1 diabetes (2008) (29)
- Secretagogue-dependent Phosphorylation of the Insulin Granule Membrane Protein Phogrin Is Mediated by cAMP-dependent Protein Kinase* (2001) (29)
- A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2 (2006) (29)
- The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release. (1979) (27)
- Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines. (2001) (27)
- Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules. (1989) (27)
- Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. (2004) (27)
- Ca2+—calmodulin dependent myosin light‐chain phosphorylating activity in insulin‐secreting tissues (1982) (26)
- Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. (1989) (25)
- A Subtractive Cloning Approach to the Identification of mRNAs Specifically Expressed in Pancreatic β-cells (1996) (25)
- HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients (2013) (25)
- Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants. (1999) (24)
- Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/Glucose-6-phosphatase Catalytic Subunit-β Results in Lowered Plasma Cholesterol and Elevated Glucagon* (2006) (24)
- Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. (2004) (24)
- T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse. (2001) (24)
- An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age (2012) (24)
- Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens. (1997) (24)
- The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. (1989) (23)
- Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein. (1984) (23)
- IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population (2012) (22)
- Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. (1984) (22)
- Two proteins act as the IUF1 insulin gene enhancer binding factor (1991) (22)
- The mechanism of chromogranin A processing (1987) (21)
- Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. (2010) (20)
- Tetrahymena: the key to the genetic analysis of the regulated pathway of polypeptide secretion? (1997) (20)
- Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system (1997) (20)
- Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo (2008) (20)
- Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop (2015) (20)
- Isolation and characterization of calmodulin from an insulin-secreting tumour. (1981) (19)
- In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions (2013) (19)
- Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. (1993) (19)
- Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals (2011) (18)
- Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes (2015) (18)
- Discordant association of islet autoantibodies with high‐risk HLA genes in Chinese type 1 diabetes (2011) (17)
- Pancreatic hormones are expressed on the surfaces of human and rat islet cells through exocytotic sites. (1989) (17)
- Kinetic analysis of the type-1 proinsulin endopeptidase by a monoclonal antibody-based immunoadsorbent assay. (1992) (17)
- Characterization of the human SLC30A8 promoter and intronic enhancer. (2011) (17)
- Mapping of conformational autoantibody epitopes in ZNT8 (2011) (17)
- Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2. (1995) (17)
- Ca2+-dependent binding of cytosolic components to insulin-secretory granules results in Ca2+-dependent protein phosphorylation. (1983) (17)
- Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. (2002) (17)
- Insulin secretion by a transplantable rat islet cell tumour (1981) (17)
- Beta-cell reactive T-cell clones from type I diabetes patients are not beta cell specific and recognize multiple antigens. (1995) (17)
- The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans (1995) (15)
- Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice (2011) (15)
- G 6 PC 2 A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion (2012) (15)
- Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. (2009) (15)
- Secretory granules (2005) (15)
- 5-Hydroxytryptamine transport in cells and secretory granules from a transplantable rat insulinoma. (1983) (15)
- Biosynthesis and storage of insulin. (1990) (14)
- Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients. (2014) (14)
- Evidence for recognition of novel islet T cell antigens by granule‐specific T cell lines from new onset type 1 diabetic patients (2000) (14)
- Pancreatic B-cells secrete a range of novel peptides besides insulin. (1984) (14)
- Radiometric assay for carboxypeptidase H (EC 3.4.17.10) and other carboxypeptidase B-like enzymes. (1989) (13)
- The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. (2004) (13)
- ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study (2015) (11)
- Methods for the measurement of insulin secretion (1990) (11)
- Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays (2012) (11)
- Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium. (2012) (11)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- T-cell reactivity to 38 kD insulin-secretory granule protein in patients with recent onset type 1 diabetes (1994) (10)
- Development of a procedure for the direct cloning of T-cell epitopes using bacterial expression systems. (1996) (10)
- GeneSpeed Beta Cell: An Online Genomics Data Repository and Analysis Resource Tailored for the Islet Cell Biologist (2008) (9)
- Stimulus-secretion coupling in the pancreatic beta-cell. (2004) (9)
- The interplay between metabolic and cationic events in islet cells: coupling factors and feedback mechanisms. (1980) (9)
- The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release METABOLIC AND FUNCTIONAL EFFECTS OF NH 4 + IN RAT ISLETS (9)
- Calcium antagonists and islet function: VII. Effect of calcium deprivation (1978) (9)
- Sequential events in the process of glucose-induced insulin release (1977) (9)
- Fuel and signal function of 2-keto acids in insulin secretion. (1980) (8)
- Conserved Epitopes in the Protein Tyrosine Phosphatase Family of Diabetes Autoantigens (2008) (8)
- Metabolic aspects of alpha-ketoisocaproic-induced insulin release in rat pancreatic islets (1977) (8)
- Establishment of Native Insulin‐Negative NOD Mice and the Methodology to Distinguish Specific Insulin Knockout Genotypes and a B:16 Alanine Preproinsulin Transgene (2004) (8)
- A rapid, sensitive and versatile two-site immunoradiometric assay for insulin (1989) (7)
- Effect of insulinotropic agents on Ca2+ translocation in an artificial system (1977) (7)
- Synergizing Genomic Analysis With Biological Knowledge to Identify and Validate Novel Genes in Pancreatic Development (2012) (7)
- Characterization of the Unusual Insulin of Psammomys obesus, a Rodent With Nutrition-Induced NIDDM-Like Syndrome (1997) (7)
- Low-molecular-weight constituents of isolated insulin-secretory granules (2005) (7)
- Chromogranin A and Its Derived Peptides in the Rat and Procine Gastro-Entero-Pancreatic System (2002) (7)
- Cytokine-Induced Dicing and Splicing in the β-Cell and the Immune Response in Type 1 Diabetes (2010) (7)
- Relationship of endogenous to dietary sorbitol. A study in normal and diabetic rats. (1979) (6)
- Nucleotide and bivalent cation specificity of the insulin-granule proton translocase. (1983) (6)
- Chromogranin A and its derived peptides in the rat and porcine gastro-entero-pancreatic system. Expression, localization, and characterization. (2000) (6)
- Targeting of a phogrin-green fluorescent protein chimaera to insulin secretory granules of pancreatic beta-cells in transgenic mice. (2002) (5)
- Pyruvate metabolism in isolated islets (1977) (5)
- Proinsulin-Processing Endopeptidases (1994) (4)
- The redox state of pyridine nucleotides in pancreatic islets and its relevance to 2-ketoisocaproate-induced insulin secretion (1978) (3)
- Getting beta all the time: discovery of reliable markers of beta cell mass (2010) (3)
- Mapping I-Ag7 restricted epitopes in murine G6PC2 (2013) (3)
- 3D Structure Studies of the Pancreatic Beta Cell by High Resolution Cellular Tomography (2003) (3)
- Localisation of islet amyloid polypeptide and its carboxy terminal flanking peptide in islets of diabetic man and monkey (1991) (3)
- The insulin secretory granule: features and functions in common with other endocrine granules. (1986) (3)
- Isolation of Dense Core Secretory Vesicles from Pancreatic Endocrine Cells by Differential and Density Gradient Centrifugation (2009) (3)
- The enzymology of proinsulin conversion (1991) (2)
- A-2b and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age (2011) (2)
- Discovering Novel Antigens (2011) (1)
- Enzymes involved in the conversion of proinsulin to insulin (1983) (1)
- Proinsulin Processing and Insulin Storage (1999) (1)
- Structure and function of islet cells: recognition of insulinotropic stimuli (1980) (1)
- Metabolism and insulinotropic action of pyruvate (1978) (1)
- [Biogenesis of the insulin secretion granule]. (1989) (1)
- Metabolic, ionic and secretory events in leucine-stimulated islets (1979) (0)
- CALMODULIN AND CALMODULIN-BINDING PROTEINS IN AN INSULIN SECRETING TUMOUR (1981) (0)
- Chapter 2 Discovering Novel Antigens (2018) (0)
- Short communication Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes (2008) (0)
- Coupling of metabolic to cationic events in the process of insulin release: Possible role of native ionophores and endogenous calmodulin (1980) (0)
- 38kDa β-cell protein as target of the autoimmune response in insulin-dependent diabetes mellitus (1996) (0)
- Human Prediabetes ) in β Diabetes Autoantigen Phogrin ( IA-2 HLA-DQ 8-Associated T Cell Responses to the Hutton (2004) (0)
- Cell Autoimmunity to Zinc Transporter 8 Human Type 1 Diabetes Is Associated with T (2011) (0)
- 4-Methyl-2-oxopentanoate in Rat Pancreatic Islets (2005) (0)
- The role of oxidative metabolism in 2-keto-isocaproate-induced insulin release (1978) (0)
- Screening for IA-2 and zinc transporter 8 antibodies identifies relatives of type 1 diabetic patients with a high and age-independent progression rate to clinical onset (2012) (0)
- Processing of Proopiornelanocortin by Insulin Secretory Granule (2001) (0)
- T-cell lines from type 1 diabetic patients to insulinoma proteins: Unresponsiveness to candidate β cell autoantigens suggests recognition of novel targets (1997) (0)
- Metabolism of alpha-ketoisocaproic acid in rat pancreatic islets (1977) (0)
- 124 Figures , 51 Tables 1980 (2011) (0)
- Mapping I-Ag7 restricted epitopes in murine G6PC2 (2012) (0)
- Betagranins; 21,000 mw peptides cosecreted with insulin are homologous to adrenal medulla chromogranin A (1985) (0)
- Rapid Publication In Vivo Activity and In Vitro Specificity of CD4+ Thi and Th2 Cells Derived from the Spleens of Diabetic NOD Mice (2004) (0)
- Ca 2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat #-cell tumour (2005) (0)
- Bioluminescence techniques in metabolic studies in pancreatic islets: Practicalities and pitfalls (1978) (0)
- Inhibitory effect of ammonium on pancreatic B-cell function (1978) (0)
- Identification of Ca2+-calmodulin dependent enzyme activities in an insulin-secreting tumour (1982) (0)
- [Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics]. (2010) (0)
- Diminished (cid:1) -cell replication contributes to reduced (cid:1) -cell mass in fetal sheep with intrauterine growth restriction (2005) (0)
- Three dimensional imaging of pancreatic islets in situ using confocal laser scanning microscopy (CLSM) (1994) (0)
- Glucose-induced insulin release: links between metabolic and cationic events (1978) (0)
- Dynamics of O2 consumption by pancreatic islets (1978) (0)
- Common and unique environmental events associated with innate and adaptive immunity in type 1 diabetes (2009) (0)
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