Johnxs C. Hutton

Q: What Schools Are Affiliated With Johnxs C. Hutton

Johnxs C. Hutton is affiliated with the following schools: University of Cambridge, Université libre de Bruxelles, University of Colorado Denver, Vanderbilt University, University of Colorado

Johnxs C. Hutton's AcademicInfluence.com Rankings

Johnxs C. Hutton

Biology

#12091

World Rank

#15542

Historical Rank

Genetics

#1316

World Rank

#1418

Historical Rank

Molecular Biology

#1925

World Rank

#1956

Historical Rank

biology Degrees

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Biology

Johnxs C. Hutton's Degrees

PhD Genetics Stanford University

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Johnxs C. Hutton's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene (1997) (1073)
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes (2007) (941)
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice (2005) (752)
Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases (1988) (347)
Insulin release: the fuel hypothesis. (1979) (335)
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. (2003) (313)
Molecular Cloning of Phogrin, a Protein-tyrosine Phosphatase Homologue Localized to Insulin Secretory Granule Membranes* (1996) (235)
Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. (1999) (229)
T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins (1990) (214)
Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. (2006) (200)
A Common Nonsynonymous Single Nucleotide Polymorphism in the SLC30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes (2008) (198)
The stimulus-secretion coupling of glucose-induced insulin release (1979) (188)
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. (2009) (176)
Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. (1983) (172)
In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. (1995) (169)
Age of Islet Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes (2011) (168)
Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes (2010) (158)
The internal pH and membrane potential of the insulin-secretory granule. (1982) (142)
Diminished β-cell replication contributes to reduced β-cell mass in fetal sheep with intrauterine growth restriction (2005) (141)
Glucose-6-phosphatase Catalytic Subunit Gene Family* (2009) (138)
Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera. (1998) (133)
The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. (1987) (133)
Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. (1992) (131)
The insulin secretory granule (1989) (129)
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell. (2000) (128)
REGULATION OF CALCIUM FLUXES AND THEIR REGULATORY ROLES IN PANCREATIC ISLETS * (1978) (120)
T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes (1991) (119)
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. (1978) (119)
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. (1978) (118)
A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. (1992) (113)
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. (1999) (109)
Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. (1989) (107)
Dense Core Vesicle Dynamics in Caenorhabditis elegans Neurons and the Role of Kinesin UNC‐104 (2004) (107)
Global gene expression profiling and histochemical analysis of the developing human fetal pancreas (2008) (104)
Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8. (2011) (104)
SlC30A8 Is a Major Target of Humoral Autoimmunity in Type 1 Diabetes and a Predictive Marker in Prediabetes (2008) (103)
On the Pathogenicity of Autoantigen-Specific T-Cell Receptors (2008) (102)
Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release. (1980) (100)
Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. (2001) (100)
Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases (1994) (97)
Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line (2009) (94)
Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10). (1987) (94)
Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. (1996) (93)
Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies (2012) (93)
The Stimulus-secretion Coupling of Amino Acid-induced Insulin Release: Metabolism and Cationic Effects of Leucine (1980) (93)
The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese (2010) (92)
Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. (2002) (89)
Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials (2010) (87)
Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins. (1991) (85)
Induction of Indoleamine 2,3-Dioxygenase by Interferon-γ in Human Islets (2007) (85)
Carboxypeptidase activity in the insulin secretory granule (1983) (84)
Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme. (1989) (84)
Novel Diabetes Autoantibodies and Prediction of Type 1 Diabetes (2013) (83)
Identification of the 37-kDa Antigen in IDDM as a Tyrosine Phosphatase-Like Protein (Phogrin) Related to IA-2 (1996) (83)
Cytokine-mediated Down-regulation of the Transcription Factor cAMP-response Element-binding Protein in Pancreatic β-Cells* (2003) (81)
T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM (1995) (80)
Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8 (2011) (80)
Contribution of Antibodies Against IA-2β and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age (2011) (79)
Cloning and Characterization of the Human and Rat Islet-specific Glucose-6-phosphatase Catalytic Subunit-related Protein (IGRP) Genes* (2001) (79)
IDA‐1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA‐2 and phogrin, is expressed in peptidergic neurons in the worm (2001) (76)
The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background (2012) (73)
Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes (2008) (72)
Cathepsin B-related proteases in the insulin secretory granule. (1984) (71)
Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. (2010) (70)
Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. (1998) (70)
Dynamics of O2 consumption in rat pancreatic islets (1980) (69)
The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets. (1981) (68)
The molecular cloning of the chromogranin A‐like precursor of β‐granin and pancreastatin from the endocrine pancreas (1988) (68)
Identification of the Region within the Neuroendocrine Polypeptide 7B2 Responsible for the Inhibition of Prohormone Convertase PC2 (*) (1995) (67)
Novel antigens in type 1 diabetes: The importance of ZnT8 (2009) (67)
Identification of a Transferable Sorting Domain for the Regulated Pathway in the Prohormone Convertase PC2* (1996) (67)
The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2. (1994) (65)
Biosynthesis of betagranin in pancreatic beta-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin. (1987) (64)
Molecular and cellular regulation of prohormone processing. (1998) (64)
Interaction of branched chain amino acids and keto acids upon pancreatic islet metabolism and insulin secretion. (1980) (62)
Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype (2007) (61)
Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway. (1990) (61)
The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. (1979) (61)
G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion (2013) (59)
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. (1978) (58)
Autoantibodies to Protein Tyrosine Phosphatase-Like Proteins In Type I Diabetes: Overlapping Specificities To Phogrin And ICA512/IA-2 (1996) (58)
Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. (2003) (58)
β‐Granins: 21 kDa co‐secreted peptides of the insulin granule closely related to adrenal medullary chromogranin A (1985) (58)
Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets. (1979) (57)
Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. (2006) (56)
Endoplasmic reticulum Ca2+ is important for the proteolytic processing and intracellular transport of proinsulin in the pancreatic beta-cell. (1997) (55)
Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules. (1982) (55)
Peptide Hormone Action: A Practical Approach (1991) (54)
The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. (1992) (54)
Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes. (1996) (53)
Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients (2012) (53)
A pancreatic β-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes (2003) (52)
Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue. (1993) (52)
Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. (2005) (51)
Argyrophilia and Granin (Chromogranin/Secretogranin) Expression in Female Breast Carcinomas Their Relationship to Survival and Other Disease Parameters (1992) (50)
The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets. (1978) (50)
Localization of pancreastatin immunoreactivity in porcine endocrine cells. (1988) (48)
Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. (1987) (48)
Immunolocalization of betagranin: a chromogranin A-related protein of the pancreatic B-cell. (1988) (48)
Recycling of the dense-core vesicle membrane protein phogrin in Min6 β-cells (2004) (46)
ETS‐family genes in pancreatic development (2007) (46)
T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. (1995) (46)
Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach (2001) (45)
Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas (2006) (45)
Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. (1991) (43)
Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells (1995) (43)
Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. (2007) (43)
Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes (2011) (43)
Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas–Kidney Transplants (2015) (43)
Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma. (1984) (42)
Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost‐effective and age‐independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients (2013) (42)
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases (2012) (41)
The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration. (1980) (40)
The tissue distribution of rat chromogranin A-derived peptides: evidence for differential tissue processing from sequence specific antisera (2004) (39)
Identification of a Major Humoral Epitope in Slc30A8 (ZnT8) (2008) (38)
A phogrin-aequorin chimaera to image free Ca2+ in the vicinity of secretory granules. (1998) (38)
Isolation and characterisation of insulin secretory granules from a rat islet cell tumour (1982) (37)
Proinsulin processing in the diabetic Goto-Kakizaki rat. (2002) (36)
Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. (1999) (36)
The Lumenal Domain of the Integral Membrane Protein Phogrin Mediates Targeting to Secretory Granules (2002) (36)
T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient. (1996) (36)
Production and characterization of monoclonal antibodies to insulin secretory granule membranes. (1987) (36)
Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse (2008) (36)
Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets (2007) (36)
The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. (2011) (35)
Peptide hormone secretion : a practical approach (1990) (34)
Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin. (1989) (34)
Proprotein-processing endopeptidases of the insulin secretory granule. (1991) (34)
HLA-DQ8-Associated T Cell Responses to the Diabetes Autoantigen Phogrin (IA-2β) in Human Prediabetes1 (2004) (33)
Biosynthesis of insulin secretory granule membrane proteins. Control by glucose. (1987) (33)
Calcium-binding proteins and secretion. (1986) (33)
An Extended Tyrosine‐Targeting Motif for Endocytosis and Recycling of the Dense‐Core Vesicle Membrane Protein Phogrin (2005) (32)
The stimulus-secretion coupling of amino acid-induced insulin release. Synergistic effects of L-glutamine and 2-keto acids upon insulin secretion. (1981) (31)
Protein Tyrosine Phosphatase-Like Proteins: Link With IDDM (1997) (31)
Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes (2000) (30)
Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue. (1999) (30)
New antigenic targets in type 1 diabetes (2008) (29)
Secretagogue-dependent Phosphorylation of the Insulin Granule Membrane Protein Phogrin Is Mediated by cAMP-dependent Protein Kinase* (2001) (29)
A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2 (2006) (29)
The stimulus--secretion coupling 4-methyl-2-oxopentanoate-induced insulin release. (1979) (27)
Characterization of the mouse islet-specific glucose-6-phosphatase catalytic subunit-related protein gene promoter by in situ footprinting: correlation with fusion gene expression in the islet-derived betaTC-3 and hamster insulinoma tumor cell lines. (2001) (27)
Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules. (1989) (27)
Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. (2004) (27)
Ca2+—calmodulin dependent myosin light‐chain phosphorylating activity in insulin‐secreting tissues (1982) (26)
Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. (1989) (25)
A Subtractive Cloning Approach to the Identification of mRNAs Specifically Expressed in Pancreatic β-cells (1996) (25)
HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients (2013) (25)
Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants. (1999) (24)
Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/Glucose-6-phosphatase Catalytic Subunit-β Results in Lowered Plasma Cholesterol and Elevated Glucagon* (2006) (24)
Identification and characterization of a cDNA and the gene encoding the mouse ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. (2004) (24)
T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse. (2001) (24)
An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age (2012) (24)
Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens. (1997) (24)
The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. (1989) (23)
Involvement of protein kinase C in the phosphorylation of an insulin-granule membrane protein. (1984) (23)
IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population (2012) (22)
Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. (1984) (22)
Two proteins act as the IUF1 insulin gene enhancer binding factor (1991) (22)
The mechanism of chromogranin A processing (1987) (21)
Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. (2010) (20)
Tetrahymena: the key to the genetic analysis of the regulated pathway of polypeptide secretion? (1997) (20)
Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system (1997) (20)
Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo (2008) (20)
Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop (2015) (20)
Isolation and characterization of calmodulin from an insulin-secreting tumour. (1981) (19)
In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions (2013) (19)
Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. (1993) (19)
Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals (2011) (18)
Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes (2015) (18)
Discordant association of islet autoantibodies with high‐risk HLA genes in Chinese type 1 diabetes (2011) (17)
Pancreatic hormones are expressed on the surfaces of human and rat islet cells through exocytotic sites. (1989) (17)
Kinetic analysis of the type-1 proinsulin endopeptidase by a monoclonal antibody-based immunoadsorbent assay. (1992) (17)
Characterization of the human SLC30A8 promoter and intronic enhancer. (2011) (17)
Mapping of conformational autoantibody epitopes in ZNT8 (2011) (17)
Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2. (1995) (17)
Ca2+-dependent binding of cytosolic components to insulin-secretory granules results in Ca2+-dependent protein phosphorylation. (1983) (17)
Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice. (2002) (17)
Insulin secretion by a transplantable rat islet cell tumour (1981) (17)
Beta-cell reactive T-cell clones from type I diabetes patients are not beta cell specific and recognize multiple antigens. (1995) (17)
The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans (1995) (15)
Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice (2011) (15)
G 6 PC 2 A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion (2012) (15)
Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes. (2009) (15)
Secretory granules (2005) (15)
5-Hydroxytryptamine transport in cells and secretory granules from a transplantable rat insulinoma. (1983) (15)
Biosynthesis and storage of insulin. (1990) (14)
Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients. (2014) (14)
Evidence for recognition of novel islet T cell antigens by granule‐specific T cell lines from new onset type 1 diabetic patients (2000) (14)
Pancreatic B-cells secrete a range of novel peptides besides insulin. (1984) (14)
Radiometric assay for carboxypeptidase H (EC 3.4.17.10) and other carboxypeptidase B-like enzymes. (1989) (13)
The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. (2004) (13)
ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study (2015) (11)
Methods for the measurement of insulin secretion (1990) (11)
Prediction of HLA class I-restricted T-cell epitopes of islet autoantigen combined with binding and dissociation assays (2012) (11)
Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium. (2012) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
T-cell reactivity to 38 kD insulin-secretory granule protein in patients with recent onset type 1 diabetes (1994) (10)
Development of a procedure for the direct cloning of T-cell epitopes using bacterial expression systems. (1996) (10)
GeneSpeed Beta Cell: An Online Genomics Data Repository and Analysis Resource Tailored for the Islet Cell Biologist (2008) (9)
Stimulus-secretion coupling in the pancreatic beta-cell. (2004) (9)
The interplay between metabolic and cationic events in islet cells: coupling factors and feedback mechanisms. (1980) (9)
The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release METABOLIC AND FUNCTIONAL EFFECTS OF NH 4 + IN RAT ISLETS (9)
Calcium antagonists and islet function: VII. Effect of calcium deprivation (1978) (9)
Sequential events in the process of glucose-induced insulin release (1977) (9)
Fuel and signal function of 2-keto acids in insulin secretion. (1980) (8)
Conserved Epitopes in the Protein Tyrosine Phosphatase Family of Diabetes Autoantigens (2008) (8)
Metabolic aspects of alpha-ketoisocaproic-induced insulin release in rat pancreatic islets (1977) (8)
Establishment of Native Insulin‐Negative NOD Mice and the Methodology to Distinguish Specific Insulin Knockout Genotypes and a B:16 Alanine Preproinsulin Transgene (2004) (8)
A rapid, sensitive and versatile two-site immunoradiometric assay for insulin (1989) (7)
Effect of insulinotropic agents on Ca2+ translocation in an artificial system (1977) (7)
Synergizing Genomic Analysis With Biological Knowledge to Identify and Validate Novel Genes in Pancreatic Development (2012) (7)
Characterization of the Unusual Insulin of Psammomys obesus, a Rodent With Nutrition-Induced NIDDM-Like Syndrome (1997) (7)
Low-molecular-weight constituents of isolated insulin-secretory granules (2005) (7)
Chromogranin A and Its Derived Peptides in the Rat and Procine Gastro-Entero-Pancreatic System (2002) (7)
Cytokine-Induced Dicing and Splicing in the β-Cell and the Immune Response in Type 1 Diabetes (2010) (7)
Relationship of endogenous to dietary sorbitol. A study in normal and diabetic rats. (1979) (6)
Nucleotide and bivalent cation specificity of the insulin-granule proton translocase. (1983) (6)
Chromogranin A and its derived peptides in the rat and porcine gastro-entero-pancreatic system. Expression, localization, and characterization. (2000) (6)
Targeting of a phogrin-green fluorescent protein chimaera to insulin secretory granules of pancreatic beta-cells in transgenic mice. (2002) (5)
Pyruvate metabolism in isolated islets (1977) (5)
Proinsulin-Processing Endopeptidases (1994) (4)
The redox state of pyridine nucleotides in pancreatic islets and its relevance to 2-ketoisocaproate-induced insulin secretion (1978) (3)
Getting beta all the time: discovery of reliable markers of beta cell mass (2010) (3)
Mapping I-Ag7 restricted epitopes in murine G6PC2 (2013) (3)
3D Structure Studies of the Pancreatic Beta Cell by High Resolution Cellular Tomography (2003) (3)
Localisation of islet amyloid polypeptide and its carboxy terminal flanking peptide in islets of diabetic man and monkey (1991) (3)
The insulin secretory granule: features and functions in common with other endocrine granules. (1986) (3)
Isolation of Dense Core Secretory Vesicles from Pancreatic Endocrine Cells by Differential and Density Gradient Centrifugation (2009) (3)
The enzymology of proinsulin conversion (1991) (2)
A-2b and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age (2011) (2)
Discovering Novel Antigens (2011) (1)
Enzymes involved in the conversion of proinsulin to insulin (1983) (1)
Proinsulin Processing and Insulin Storage (1999) (1)
Structure and function of islet cells: recognition of insulinotropic stimuli (1980) (1)
Metabolism and insulinotropic action of pyruvate (1978) (1)
[Biogenesis of the insulin secretion granule]. (1989) (1)
Metabolic, ionic and secretory events in leucine-stimulated islets (1979) (0)
CALMODULIN AND CALMODULIN-BINDING PROTEINS IN AN INSULIN SECRETING TUMOUR (1981) (0)
Chapter 2 Discovering Novel Antigens (2018) (0)
Short communication Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes (2008) (0)
Coupling of metabolic to cationic events in the process of insulin release: Possible role of native ionophores and endogenous calmodulin (1980) (0)
38kDa β-cell protein as target of the autoimmune response in insulin-dependent diabetes mellitus (1996) (0)
Human Prediabetes ) in β Diabetes Autoantigen Phogrin ( IA-2 HLA-DQ 8-Associated T Cell Responses to the Hutton (2004) (0)
Cell Autoimmunity to Zinc Transporter 8 Human Type 1 Diabetes Is Associated with T (2011) (0)
4-Methyl-2-oxopentanoate in Rat Pancreatic Islets (2005) (0)
The role of oxidative metabolism in 2-keto-isocaproate-induced insulin release (1978) (0)
Screening for IA-2 and zinc transporter 8 antibodies identifies relatives of type 1 diabetic patients with a high and age-independent progression rate to clinical onset (2012) (0)
Processing of Proopiornelanocortin by Insulin Secretory Granule (2001) (0)
T-cell lines from type 1 diabetic patients to insulinoma proteins: Unresponsiveness to candidate β cell autoantigens suggests recognition of novel targets (1997) (0)
Metabolism of alpha-ketoisocaproic acid in rat pancreatic islets (1977) (0)
124 Figures , 51 Tables 1980 (2011) (0)
Mapping I-Ag7 restricted epitopes in murine G6PC2 (2012) (0)
Betagranins; 21,000 mw peptides cosecreted with insulin are homologous to adrenal medulla chromogranin A (1985) (0)
Rapid Publication In Vivo Activity and In Vitro Specificity of CD4+ Thi and Th2 Cells Derived from the Spleens of Diabetic NOD Mice (2004) (0)
Ca 2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat #-cell tumour (2005) (0)
Bioluminescence techniques in metabolic studies in pancreatic islets: Practicalities and pitfalls (1978) (0)
Inhibitory effect of ammonium on pancreatic B-cell function (1978) (0)
Identification of Ca2+-calmodulin dependent enzyme activities in an insulin-secreting tumour (1982) (0)
[Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics]. (2010) (0)
Diminished (cid:1) -cell replication contributes to reduced (cid:1) -cell mass in fetal sheep with intrauterine growth restriction (2005) (0)
Three dimensional imaging of pancreatic islets in situ using confocal laser scanning microscopy (CLSM) (1994) (0)
Glucose-induced insulin release: links between metabolic and cationic events (1978) (0)
Dynamics of O2 consumption by pancreatic islets (1978) (0)
Common and unique environmental events associated with innate and adaptive immunity in type 1 diabetes (2009) (0)

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