James C. Powers

James C. Powers's AcademicInfluence.com Rankings

James C. Powers

Chemistry

#4035

World Rank

#5091

Historical Rank

Organic Chemistry

#647

World Rank

#741

Historical Rank

chemistry Degrees

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Chemistry

James C. Powers's Degrees

PhD Chemistry Stanford University
Bachelors Chemistry University of California, Berkeley

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James C. Powers's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Irreversible inhibitors of serine, cysteine, and threonine proteases. (2002) (813)
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site. (1979) (549)
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions (1992) (460)
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors. (1989) (355)
Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. (1979) (251)
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. (2008) (241)
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. (1991) (236)
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor. (1985) (225)
Calpain Inhibitor AK295 Protects Neurons From Focal Brain Ischemia: Effects of Postocdusion Intra-arterial Administration (1994) (214)
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex. (1992) (210)
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones. (1977) (189)
Irreversible inhibition of serine proteases by peptide derivatives of (alpha-aminoalkyl)phosphonate diphenyl esters. (1991) (182)
Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors. (2000) (174)
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. (1985) (173)
Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors. (1971) (154)
Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide (2005) (148)
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. (1995) (138)
The 1.8 A crystal structure of human cathepsin G in complex with Suc‐Val‐Pro‐PheP‐(OPh)2: a Janus‐faced proteinase with two opposite specificities. (1996) (137)
An x-ray crystallographic study of the binding of peptide chloromethyl ketone inhibitors to subtilisin BPN'. (1972) (137)
Calpain as a novel target for treating acute neurodegenerative disorders. (1995) (127)
Novel Peptidyl α-Keto Amide Inhibitors of Calpains and Other Cysteine Proteases (1996) (125)
Calpain inhibition protects against Taxol-induced sensory neuropathy. (2003) (124)
Design of potent reversible inhibitors for thermolysin. Peptides containing zinc coordinating ligands and their use in affinity chromatography. (1979) (120)
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand. (1980) (118)
Inhibition of thermolysin and carboxypeptidase A by phosphoramidates. (1979) (113)
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases (2003) (109)
The Human Cytotoxic T Cell Granule Serine Protease Granzyme H Has Chymotrypsin-like (Chymase) Activity and Is Taken Up into Cytoplasmic Vesicles Reminiscent of Granzyme B-containing Endosomes* (1999) (108)
Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. (1997) (102)
Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases. (1993) (97)
Peptide hydroxamic acids as inhibitors of thermolysin. (1978) (96)
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates. (1983) (96)
Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates. (1984) (94)
Subsite specificity of porcine pepsin. (1977) (88)
Novel amidine-containing peptidyl phosphonates as irreversible inhibitors for blood coagulation and related serine proteases. (1994) (87)
The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors. (1991) (87)
Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors. (1985) (85)
Dipeptide phosphonates as inhibitors of dipeptidyl peptidase IV. (1994) (83)
Mass spectrometry of simple indoles (1968) (83)
Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin). (1980) (83)
Reaction of azapeptides with human leukocyte elastase and porcine pancreatic elastase. New inhibitors and active site titrants. (1984) (81)
Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates. (1981) (79)
Amino acid and peptide phosphonate derivatives as specific inhibitors of serine peptidases. (1994) (79)
Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors. (1985) (75)
Conversion of the substrate specificity of mouse proteinase granzyme B (1994) (73)
A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates. (1982) (70)
A zinc metalloendopeptidase associated with dog pancreatic membranes. (1980) (70)
Active-site specific inhibitors of elastase. (1973) (69)
Mechanistic and structural insights into the proteolytic activation of Vibrio cholera MARTX toxin (2009) (68)
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. (2004) (68)
Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants. (1988) (67)
Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates. (1987) (66)
Biotinylated isocoumarins, new inhibitors and reagents for detection, localization, and isolation of serine proteases. (1993) (65)
Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. (1993) (64)
Substrate and inhibitor studies on proteinase 3 (1992) (62)
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. (1992) (61)
Influenza C virus esterase: analysis of catalytic site, inhibition, and possible function (1989) (60)
Reactivity of human leukocyte elastase and porcine pancreatic elastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is selective for cross-linked regions of elastin. (1981) (60)
Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion (2013) (59)
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. (2006) (59)
Substrate specificity of transthyretin: identification of natural substrates in the nervous system. (2009) (57)
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. (1984) (55)
Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice. (2004) (54)
Characterisation of the antitrypanosomal activity of peptidyl alpha-aminoalkyl phosphonate diphenyl esters. (2000) (53)
Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase. (1998) (53)
The aromatic substrate binding site in subtilisin BPN' and its resemblance to chymotrypsin. (1972) (53)
Fluorescent derivatives of diphenyl [1-(N-peptidylamino)alkyl]phosphonate esters: synthesis and use in the inhibition and cellular localization of serine proteases. (1994) (52)
Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G. (1980) (51)
Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements. (1987) (51)
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. (2004) (47)
Mechanism‐based isocoumarin inhibitors for serine proteases: Use of active site structure and substrate specificity in inhibitor design (1989) (47)
Irreversible inhibition of serine proteases by peptidyl derivatives of alpha-aminoalkylphosphonate diphenyl esters. (1989) (46)
Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase (2006) (46)
Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency. (1994) (46)
Reaction of azapeptides with chymotrypsin-like enzymes. New inhibitors and active site titrants for chymotrypsin A alpha, subtilisin BPN', subtilisin Carlsberg, and human leukocyte cathepsin G. (1984) (46)
Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis (2013) (46)
Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. (2008) (45)
Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity. (2002) (45)
Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models. (1996) (45)
Kinetics of the reaction of chymotrypsin A with peptide chloromethyl ketones in relation to its subsite specificity. (1973) (44)
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. (2011) (44)
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. (2002) (43)
Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions. (2008) (42)
Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system. (1998) (41)
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides. (1978) (41)
Virus-specified protease in poliovirus-infected HeLa cells. (1979) (40)
Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C). (2004) (40)
Mapping the substrate binding site of human C1r and C1s with peptide thioesters. Development of new sensitive substrates. (1981) (39)
Synthesis of Piperidylindoles (1965) (39)
Lymphocyte granule-mediated cytolysis requires serine protease activity. (1987) (39)
Reaction of serine proteases with aza-amino acid and aza-peptide derivatives. (1977) (38)
Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors. (1985) (38)
Inhibition of human leukocyte elastase by peptide chloromethyl ketones (1975) (38)
Substituted isocoumarins as inhibitors of complement serine proteases. (1992) (37)
Active site directed irreversible inhibition of thermolysin. (1978) (37)
Reaction of acyl carbazates with proteolytic enzymes. (1975) (36)
Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). (1997) (36)
Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis (2016) (36)
Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxicity. (1994) (35)
Electrostatic reversal of serine proteinase substrate specificity (1999) (35)
Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. (1990) (35)
Catalysis by human leukocyte elastase: proton inventory as a mechanistic probe. (1987) (35)
Cutaneous protease activity in the mouse ear vesicant model † (2000) (34)
Reaction of peptide thiobenzyl esters with mammalian chymotrypsinlike enzymes: a sensitive assay method. (1981) (34)
Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. (2004) (34)
X‐ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors (1995) (34)
Determination of proteinase 3—α1‐antitrypsin complexes in inflammatory fluids (1992) (34)
Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors. (1982) (33)
Effect of neutrophil cathepsin G on elastin degradation by neutrophil elastase. (1984) (32)
Human leucocyte elastase and cathepsin G: structural and functional characteristics. (2008) (32)
Albumin microspheres as carrier of an inhibitor of leukocyte elastase: potential therapeutic agent for emphysema. (1979) (30)
[16] Reaction of serine proteases with halomethyl ketones (1977) (30)
Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). (2009) (30)
Synthesis and kinetic studies of diphenyl 1-(N-peptidylamino)alkanephosphonate esters and their biotinylated derivatives as inhibitors of serine proteases and probes for lymphocyte granzymes. (1997) (30)
Reactivity of bovine blood coagulation factor IXa beta, factor Xa beta, and factor XIa toward fluorogenic peptides containing the activation site sequences of bovine factor IX and factor X. (1983) (29)
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. (1992) (29)
[31] Isocoumarin inhibitors of serine peptidases (1994) (28)
Oxyanion-mediated inhibition of serine proteases. (1998) (28)
A chemical and crystallographic study of carbamyl-chymotrypsin A. (1972) (28)
Aza-Peptide Epoxides: Potent and Selective Inhibitors of Schistosoma mansoni and Pig Kidney Legumains (Asparaginyl Endopeptidases) (2003) (28)
Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis. (1998) (27)
Active-site specific inhibitors of elastase. (1972) (27)
3-Alkoxy-7-amino-4-chloroisocoumarins: a new class of suicide substrates for serine proteases (1984) (27)
Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. (1995) (26)
Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex. (1991) (25)
Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. (2010) (25)
The 2.2 .ANG. resolution x-ray crystal structure of the complex of trypsin inhibited by 4-chloro-3-ethoxy-7-guanidinoisocoumarin: a proposed model of the thrombin-inhibitor complex (1990) (25)
The stereochemistry of substrate binding to chymotrypsin A . (1972) (25)
Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors. (2006) (24)
Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. (1996) (24)
Peptide thioester substrates for serine peptidases and metalloendopeptidases. (1995) (23)
Total synthesis of the diazaphenanthrene alkaloid perlolidine (1968) (22)
Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: a 1.85-A X-ray structure of the complex between porcine pancreatic elastase and 7-[(N-tosylphenylalanyl)amino]-4-chloro-3- methoxyisocoumarin. (1992) (22)
Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin. (1992) (22)
Selective isocoumarin serine protease inhibitors block RNK-16 lymphocyte granule-mediated cytolysis. (1989) (21)
Novel substrates for angiotensin I converting enzyme. (1983) (20)
Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates. (2004) (20)
Synthetic elastase inhibitors: prospects for use in the treatment of emphysema. (2015) (20)
PROTEOLYTIC EVENTS IN REPLICATION OF ANIMAL VIRUSES (1980) (20)
Design and synthesis of inhibitors for crystallographic studies on the active site of chymotrypsin. (1970) (19)
Efficacy of novel calpain inhibitors in preventing renal cell death. (2000) (19)
The synthesis of arginylfluoroalkanes, their inhibition of trypsin and blood-coagulation serine proteinases and their anticoagulant activity. (1990) (18)
New mechanism-based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthalide (1983) (18)
A new dimerization reaction producing 2-amino-9-oxopyrrolo-[2,1-b]quinazoline-1-carbonitriles and analogous pyrrolo-[1,2-a]thieno[3,2-d] pyrimidinecar bonitriles (2001) (18)
Kinetics of hydrolysis of peptide thioester derivatives of arginine by human and bovine thrombins. (1984) (17)
Proteases--structures, mechanism and inhibitors. (1993) (16)
Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A alpha, and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones. (1985) (16)
A GENERAL CLEAVAGE REACTION OF 3-SUBSTITUTED INDOLES. (1965) (16)
The Stereochemistry of Elimination Reactions. The 2,3-Dihalonorbornanes (1963) (16)
Mechanism-based isocoumarin inhibitors for trypsin-like serine proteases involved in blood coagulation (1987) (16)
A serine proteinase inactivator inhibits chondrocyte-mediated cartilage proteoglycan breakdown occurring in response to proinflammatory cytokines. (1998) (16)
Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes. (1988) (15)
Synthetic Substrates and Inhibitors of Thrombin (1992) (15)
Rates of thrombin acylation and deacylation upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylating agents. (1995) (15)
Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme. (1993) (15)
PROTEASE ACTIVITIES PRESENT IN DOG PANCREATIC MEMBRANES THAT PROCESS HUMAN PRE‐PLACENTAL LACTOGEN (1980) (15)
Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I. (2001) (15)
Isocoumarin inhibitors of serine peptidases. (1994) (14)
Thioester Chromogenic Substrates for Human Factor VIIa: Substituted Isocoumarins Are Inhibitors of Factor VIIa and In Vitro Anticoagulants (1990) (13)
Enhanced Serine Protease Activities in the Sulfur Mustard-Exposed Homogenates of Hairless Guinea Pig Skin (1997) (13)
Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes. (1998) (13)
Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes). (1996) (13)
alpha-Aminoalkylphosphonate di(chlorophenyl) esters as inhibitors of serine proteases. (1994) (13)
The Reaction of Formates and Formamides with Base1 (1966) (13)
Inhibition of Arginine Gingipains (RgpB and HRgpA) with Benzamidine Inhibitors: Zinc Increases Inhibitory Potency (2002) (13)
Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1. (1999) (13)
Inhibitors of elastase and pulmonary emphysema (1976) (13)
Protonation of the indole Grignard reagent and other organometallic derivatives of indole (1967) (13)
Ion beam tritium labeling of proteins and peptides. (1981) (12)
Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chambers (2004) (11)
Mammalian tissue trypsin-like enzymes: substrate specificity and inhibitory potency of substituted isocoumarin mechanism-based inhibitors, benzamidine derivatives, and arginine fluoroalkyl ketone transition-state inhibitors. (1995) (11)
Determination of activable proacrosin/acrosin in bovine sperm using an irreversible isocoumarin serine protease inhibitor. (1996) (11)
Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase). (1984) (11)
Aza-Peptide Epoxides: A New Class of Inhibitors Selective for Clan CD Cysteine Proteases (2003) (11)
SYNTHETIC ACTIVE SITE‐DIRECTED INHIBITORS OF ELASTOLYTIC PROTEASES * (1975) (10)
Elastase inhibitors for treatment of emphysema. Approaches to synthesis and biological evaluation. (1987) (10)
Inhibition of subtilisin BPN' with peptide chloromethyl ketones. (1977) (10)
P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes. (1997) (10)
2-Alkylthio-4-oxo-3-quinazolineacetonitriles and analogous thieno[3,2-d]pyrimidineacetonitriles: reaction with thiols via trapped thioimidates. (2001) (9)
Synthetic protease inhibitors (1979) (9)
Inhibition of chymotrypsin A-alpha with N-acyl- and N-peptidyl-2-phenylethyl amines. Subsite binding free energies. (1974) (9)
Further evidence for the importance of free carboxylate in epoxysuccinate inhibitors of thiol proteases. (1993) (9)
1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhibitors (1994) (8)
In vivo determination of the anticoagulant effect of a substituted isocoumarin (ACITIC). (1990) (8)
Peptide thioesters and 4-nitroanilides as substrates for porcine pancreatic kallikrein. (1984) (8)
Reaction of serine proteases with halomethyl ketones. (1977) (7)
Benzyl p-guanidinothiobenzoate hydrochloride, a new active-site titrant for trypsin and trypsin-like enzymes. (1983) (7)
The cleavage of formyl groups by sodium hydride (1965) (7)
PROTEIN SYNTHESIS AND CLEAVAGE IN PICORNAVIRUS-INFECTED CELLS (1980) (6)
MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition (2007) (6)
Determination of proteinase 3-alpha 1-antitrypsin complexes in inflammatory fluids. (1992) (5)
Comparison of tritiation efficiency using3H3+ and3H2+ ion beams (1984) (4)
Synthetic Mechanism-Based and Transition-State Inhibitors for Human Neutrophil Elastase (1992) (4)
Inhibition of thrombin by arginine-containing peptide chloromethyl ketones and bis chloromethyl ketone-albumin conjugates. (1995) (4)
Proteolytic Enzymes and Their Active-Site-Specific Inhibitors: Role in the Treatment of Disease (1982) (4)
Specificity of Cucumisin in Hydrolysis of Peptide Thiobenzyl Esters (1986) (4)
A kinetic study of the hydrolysis of the N-tosylalanine ester of 3-hydroxy-5-phenylpyrrole and related compounds by human leukocyte elastase. (1995) (4)
A New Dimerization Reaction Producing 2-Amino-9-oxopyrrolo[2,1-b]quinazoline-1-carbonitriles and Analogous Pyrrolo[1,2-a]thieno[3,2-d]pyrimidinecarbonitriles. (2001) (3)
Low pressure tritiation of proteins. (1979) (3)
Tritium labeling of thermolysin, elastase, and ribonuclease by exposure to tritium gas at low pressure. (1980) (3)
Substrate specificity and inhibitors of a capillary injury-related protease from sheep lung lymph. (1989) (3)
Novel pyridinium derivatives as inhibitors for acetylcholinesterase. (1996) (3)
4-Chloro-7-(iodoacetyl)amino-3-methoxy-isocoumarin. (1996) (3)
Active site titration of the serine protease cucumisin from Cucumis melo (1986) (3)
Human Leukocyte Elastase and Porcine Pancreatic Elastase (2001) (3)
Modification of chymotrypsin with the specific cyanate reagent N-acetyl-p-cyanato-l-phenylalanine ethyl ester. (1976) (3)
Ex situ treatment of MTBE‐containing groundwater by a UV peroxide system (2006) (3)
Michaelis complexes of porcine pancreatic elastase with 7‐[(alkylcarbamoyl)amino]‐4‐chloro‐3‐ethoxyisocoumarins: Translational sampling of inhibitor position and kinetic measurements (1992) (2)
MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition (2007) (2)
Inhibition of porcine pancreatic elastase by 7-substituted 4-chloro-3-ethoxyisocoumarins: structural characteristics of modeled noncovalent complexes relate to the measured inhibition kinetics. (1993) (2)
Is menstruation a contraindication to thrombolytic therapy? (1992) (2)
Use of Protease Inhibitors as Probes for Biological Functions: Conditions, Controls, and Caveats (1993) (2)
Serine Protease Control of Lymphocyte-Mediated Cytolysis (1993) (1)
Synthetic substrates and inhibitors for serine proteases from lymphocytes, mast cells, semen, and blood. (1992) (1)
INHIBITION OF CHYMOTRYPSIN A(ALPHA) WITH N-ACYL- AND N-PEPTIDYL-2-PHENYLETHYLAMINES, SUBSITE BINDING FREE ENERGIES (1974) (1)
Haloindoles and Organometallic Derivatives of Indoles (2008) (1)
Erratum: MHP-133, a drug with multiple CNS targets: Potential for neuroprotection and enhanced cognition (Neurochemical Research 32, 7, (1224-1237) DOI: 10.1007/s11064-007-9294-0) (2007) (1)
CONFERENCE REPORT? ELASTASE INHIBITORS FOR TREATMENT OF EMPHYSEMA APPROACHES TO SYNTHESIS AND BIOLOGICAL EVALUATION (1987) (0)
BETA-TRYPSIN COMPLEXED WITH ACPU (1998) (0)
COMPLEX OF 3-MERCAPTO-2-BENZYLPROPANOYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (1996) (0)
Derives de la proline phosphonate (1995) (0)
Elastase inhibitors for treatment of emphysema. Approaches to synthesis and biological evaluation. (1986) (0)
Crystal structures of SARS coronavirus main peptidase inhibited by an aza-peptide epoxide in space group P212121 (2005) (0)
X-ray study of enzyme-small molecular interactions (1975) (0)
BETA-TRYPSIN PHOSPHONATE INHIBITED (1996) (0)
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors. (2007) (0)
Inhibitors for coagulation proteases (1992) (0)
Perforin-Mediated Lysis Chymase I, a Granzyme Implicated in Purification and Characterization of Lymphocyte (1998) (0)
Design and synthesis of elastase inhibitors for the treatment of emphysema and related diseases (1973) (0)
Protease inhibitors as antivesicants (1991) (0)
Crystal structure of SARS coronavirus main peptidase (with an additional Ala at the N-terminus of each protomer) in the space group P43212 (2006) (0)
Axonal protection for multiple sclerosis (2009) (0)
Active site titration of human complement components C1̄s and C1̄r with [3H]-(p-amidinophenyl) methanesulfonyl fluoride (1982) (0)
ATTEMPTED SYNTHESIS OF BERYLLIUM HYDRIDE (1960) (0)
Stimulation of Brain Nicotinic Acetylcholine Receptors (nAChR) and Inhibition of Brain Acetylcholinesterase (AChE) Activity (1997) (0)
Elastase Inhibitors for Treatment of Emphysema (2015) (0)
Calpain Assays , Nerve injury and Repair Annual Progress Report ( G-3 3Y 44 ) April 2001 (2008) (0)
Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. (2006) (0)
Purification and Characterization of Lymphocyte Chymase I , a Granzyme Implicated in Perforin-Mediated Lysis 1 (1998) (0)
Acetylcholinesterase inhibitors and dementias (1993) (0)
Mechanism-Based Isocoumarin Inhibitors for Trypsin-Like Serine Proteases Involved in Blood Coagulation. (1987) (0)
Synthesis of elastase inhibitors (1974) (0)
Biochemical Markers and Synthetic Protease Inhibitors in Animal Models of Sulfur Mustard Vesication. (1999) (0)
Cytotoxic T-lymphocyte serine proteases: Substrate and inhibitor studies with granzymes A and B, and human Q31 chymase (1992) (0)
A total synthesis of the diazaphanthrene alkaloid perlolidine. (1968) (0)
Crystal structure of SARS coronavirus main peptidase at pH 6.0 in the space group P21 (2006) (0)
Amino Acid And Peptide Thioeters: New Sensitive Substrates For Bovine Factors IXa , Xa , XIa , XIIa , Thrombin, Plasma Kallikrein And Trypsin (1981) (0)
Calpain assays, nerve injury and repair (2000) (0)
United States PateIDtt (1999) (0)
COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) (1996) (0)
Crystal structure of unbound SARS coronavirus main peptidase in the space group C2 (2005) (0)
Synthetic elastase inhibitors (1985) (0)
Inhibitors for blood coagulation proteases (1987) (0)
Reaction of Azapeptides with Chymotrypsin-like Enzymes 4281 (2001) (0)
Structures of SARS coronavirus main protease bound by an Aza-peptide epoxide (2005) (0)
Limited proteolysis and viral replication. (1980) (0)
Crystal structure of SARS coronavirus main peptidase (with an additional Ala at the N-terminus of each protomer) inhibited by an aza-peptide epoxide in the space group P43212 (2006) (0)
Active site studies on blood proteases (1980) (0)

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What Schools Are Affiliated With James C. Powers?

James C. Powers is affiliated with the following schools:

Icahn School of Medicine at Mount Sinai
Queen's University at Kingston
University of Manitoba
Georgia Tech
University of Zurich