What Schools Are Affiliated With Justin C. Reed

Justin C. Reed is affiliated with the following schools: University of Pennsylvania, University of Amsterdam, Institute of Cancer Research, Indiana University, MD Anderson Cancer Center, ETH Zurich, University of California, San Diego, Yamaguchi University, Sanford Burnham Prebys Medical Discovery Institute, University of Chicago, University of Toronto, Columbia University, Uniformed Services University of the Health Sciences, Duke University, National University of Ireland, Ohio State University, University of Konstanz, University of British Columbia, Virginia Commonwealth University, Georgetown University

Justin C. Reed | Academic Influence

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Justin C. Reed's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mitochondria and apoptosis. (1998) (5507)
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene (1995) (4314)
Regulation of cell death protease caspase-9 by phosphorylation. (1998) (3357)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours (2005) (3269)
Mitochondrial control of cell death (2000) (3146)
IAP family proteins--suppressors of apoptosis. (1999) (2672)
Bcl-2 and the regulation of programmed cell death (1994) (2404)
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. (1994) (2233)
Endoplasmic reticulum stress: cell life and death decisions. (2005) (2162)
X-linked IAP is a direct inhibitor of cell-death proteases (1997) (2085)
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner (1999) (1998)
Apoptosis in the failing human heart. (1997) (1752)
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities (2008) (1685)
Bax directly induces release of cytochrome c from isolated mitochondria. (1998) (1579)
Double identity for proteins of the Bcl-2 family (1997) (1570)
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002) (1543)
ER stress-induced cell death mechanisms. (2013) (1542)
IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases (1998) (1509)
Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype (1997) (1445)
The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases (1997) (1412)
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. (1998) (1325)
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. (1998) (1196)
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. (1999) (1190)
Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. (1993) (1142)
Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. (1996) (1135)
Anchorage dependence, integrins, and apoptosis (1994) (1085)
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. (2006) (964)
Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity (1995) (893)
Mechanisms of apoptosis. (2000) (862)
Bcl-2 family proteins and cancer (2008) (856)
Identification of a p53-dependent negative response element in the bcl-2 gene. (1994) (819)
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. (1993) (818)
Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria (1996) (814)
The NLR gene family: a standard nomenclature. (2008) (805)
Cytochrome c: Can't Live with It—Can't Live without It (1997) (801)
Dysregulation of apoptosis in cancer. (1998) (793)
Pro-caspase-3 Is a Major Physiologic Target of Caspase-8* (1998) (787)
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases (1999) (780)
Bcl-2 family proteins (1998) (768)
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA (1993) (760)
The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins (1998) (735)
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis (2000) (722)
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. (1998) (722)
FAP-1: a protein tyrosine phosphatase that associates with Fas. (1995) (707)
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. (1994) (703)
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. (2007) (681)
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. (1995) (656)
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. (2000) (656)
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases* (1998) (652)
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. (1996) (650)
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. (2000) (646)
Channel formation by antiapoptotic protein Bcl-2. (1997) (645)
Apoptosis-based therapies (2002) (641)
Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3 (2004) (639)
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (2001) (613)
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. (2004) (612)
Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria (1994) (604)
Lysosomal Protease Pathways to Apoptosis (2001) (576)
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy (2000) (565)
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. (1999) (560)
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. (1994) (543)
Humanin peptide suppresses apoptosis by interfering with Bax activation (2003) (541)
bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. (1992) (530)
Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. (1997) (526)
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. (1998) (522)
Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene (1993) (521)
Caspase-9 Can Be Activated without Proteolytic Processing* (1999) (518)
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. (1995) (514)
BAG‐1 modulates the chaperone activity of Hsp70/Hsc70 (1997) (513)
Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. (1995) (513)
An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators* (1999) (503)
cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2 (2003) (503)
Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. (1993) (502)
Apoptosis-targeted therapies for cancer. (2003) (500)
BCL‐2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy (1996) (493)
Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2 (*) (1996) (478)
The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore (2000) (474)
Heat-shock proteins as regulators of apoptosis (2003) (472)
Immunohistochemical analysis of in vivo patterns of Bcl-X expression. (1994) (463)
Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins* (2004) (462)
Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. (1997) (462)
Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. (1995) (458)
bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia (1993) (458)
Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities (2006) (453)
HBXIP functions as a cofactor of survivin in apoptosis suppression (2003) (444)
Upregulation of bax protein levels in neurons following cerebral ischemia (1995) (443)
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. (2004) (442)
Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. (1997) (440)
The bioenergetic signature of cancer: a marker of tumor progression. (2002) (438)
The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. (2002) (418)
Integrin Activation by R-ras (1996) (418)
Apoptosis-based therapies for hematologic malignancies. (2005) (414)
An IAP-IAP Complex Inhibits Apoptosis* (2004) (413)
Bid Is Cleaved by Calpain to an Active Fragment in Vitro and during Myocardial Ischemia/Reperfusion* (2001) (408)
Bcl-2 family proteins and mitochondria. (1998) (408)
MEK/ERK signaling pathway regulates the expression of Bcl‐2, Bcl‐XL, and Mcl‐1 and promotes survival of human pancreatic cancer cells (2000) (407)
Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems. (1996) (401)
An informatics approach identifying markers of chemosensitivity in human cancer cell lines. (2000) (400)
Molecular chaperone targeting and regulation by BAG family proteins (2001) (396)
Mechanisms of apoptosis avoidance in cancer. (1999) (391)
Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐xL) but not pro‐apoptotic (bax, bcl‐xS) gene expression (1996) (389)
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. (1996) (376)
p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis (2000) (373)
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. (2003) (367)
Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997. (2007) (366)
Structure-Function Analysis of Bcl-2 Protein (1995) (365)
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. (1996) (359)
Programmed myocyte cell death affects the viable myocardium after infarction in rats. (1996) (358)
Bax cleavage is mediated by calpain during drug-induced apoptosis (1998) (355)
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator (2000) (353)
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. (1998) (350)
Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells (1996) (349)
An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis* (2002) (345)
Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. (1995) (345)
BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites* (2000) (342)
Role of Excitatory Amino Acid Transporter‐2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics (2011) (340)
Apoptosis-regulating proteins as targets for drug discovery. (2001) (337)
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha. (2005) (335)
Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV. (1986) (335)
bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. (1993) (331)
Bcl-2: prevention of apoptosis as a mechanism of drug resistance. (1995) (326)
Bcl-2-family proteins and hematologic malignancies: history and future prospects. (2008) (324)
Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms. (1988) (319)
Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1 (2007) (319)
The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2. (1995) (315)
Bcl-2 family proteins as ion-channels (1998) (315)
Yeast and apoptosis (2002) (312)
Myocardial cell death in fibrillating and dilated human right atria. (1999) (312)
Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. (1996) (305)
Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. (1990) (305)
Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells (1996) (298)
Bcl-2 interrupts the ceramide-mediated pathway of cell death. (1996) (293)
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. (2004) (292)
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. (1996) (292)
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. (2009) (290)
Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2 (2001) (289)
Human Daxx regulates Fas‐induced apoptosis from nuclear PML oncogenic domains (PODs) (1999) (286)
XIAP mediates NOD signaling via interaction with RIP2 (2009) (284)
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. (2000) (280)
Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes. (1986) (277)
Mechanisms of Transcriptional Activation of bcl-2Gene Expression by 17β-Estradiol in Breast Cancer Cells* (1999) (276)
A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy (2010) (271)
Mitochondria-dependent apoptosis and cellular pH regulation (2000) (271)
Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. (1995) (271)
Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study. (2006) (266)
The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. (1998) (266)
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. (2002) (262)
ATM mutations in B-cell chronic lymphocytic leukemia. (1999) (260)
The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells. (1998) (258)
Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. (2003) (258)
WT1 modulates apoptosis by transcriptionally upregulating the bcl‐2 proto‐oncogene (1999) (253)
Elevated expression of inhibitor of apoptosis proteins in prostate cancer. (2003) (252)
Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis* (1996) (247)
The Survivin saga goes in vivo. (2001) (247)
Pediatric acute lymphoblastic leukemia. (2003) (244)
X-linked Inhibitor of Apoptosis Protein (XIAP) Inhibits Caspase-3 and -7 in Distinct Modes* (2001) (244)
BCL-X expression in multiple myeloma: possible indicator of chemoresistance. (1998) (244)
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. (2000) (242)
Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (1998) (240)
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins (2006) (239)
Cell‐free reconstitution of Fas‐, UV radiation‐ and ceramide‐induced apoptosis. (1995) (237)
Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. (1991) (235)
Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. (1996) (235)
The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. (1995) (234)
Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (1998) (230)
Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation 1 (2003) (229)
Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. (2005) (229)
Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex (2000) (223)
Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. (1996) (223)
CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. (1996) (223)
Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons. (1994) (222)
Targeting the Bcl-2 family for cancer therapy (2013) (218)
A Diverse Family of Proteins Containing Tumor Necrosis Factor Receptor-associated Factor Domains* (2001) (217)
Dysregulation of apoptosis in cancer. (1998) (217)
p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1 (1998) (214)
Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. (1996) (214)
The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells (2002) (214)
Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro. (2000) (213)
Apaf-1/Cytochrome c-independent and Smac-dependent Induction of Apoptosis in Multiple Myeloma (MM) Cells* (2001) (213)
BAG3 deficiency results in fulminant myopathy and early lethality. (2006) (212)
The Domains of Apoptosis: A Genomics Perspective (2004) (212)
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore (1999) (211)
Intracellular Delivery of Proteins with a New Lipid-mediated Delivery System* (2001) (210)
Bryostatin and CD40‐ligand enhance apoptosis resistance and induce expression of cell survival genes in B‐cell chronic lymphocytic leukaemia (1999) (208)
Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation. (1987) (207)
Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential (2005) (207)
The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf (2000) (206)
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. (2008) (206)
The AKT kinase is activated in multiple myeloma tumor cells. (2001) (204)
Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells. (1994) (204)
Prognostic significance of apoptosis regulators in breast cancer. (1999) (203)
Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. (1998) (203)
Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. (2000) (202)
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth. (2000) (199)
Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. (2003) (197)
A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection (1996) (195)
Up‐regulation of Bax Protein in Degenerating Retinal Ganglion Cells Precedes Apoptotic Cell Death after Optic Nerve Lesion in the Rat (1997) (194)
BAG-1L Protein Enhances Androgen Receptor Function* (1998) (193)
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40 (1995) (192)
Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy. (1997) (192)
Molecular Determinants of AHPN (CD437)-Induced Growth Arrest and Apoptosis in Human Lung Cancer Cell Lines (1998) (192)
Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. (1992) (190)
Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast. (2003) (190)
Programmed cell death and expression of the protooncogene bcl-2 in myocytes during postnatal maturation of the heart. (1995) (190)
Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID* (1999) (190)
TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction* (1999) (190)
Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression. (1994) (190)
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. (2004) (189)
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. (2000) (188)
Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death (2003) (188)
The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells. (1994) (188)
The triterpenoid CDDO induces apoptosis in refractory CLL B cells. (2002) (187)
Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms (2006) (184)
A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis* (2001) (183)
Targeting Mcl-1 for the therapy of cancer (2011) (183)
Endogenous Inhibitors of Caspases (1999) (183)
Identification and Functional Characterization of the BAG Protein Family in Arabidopsis thaliana* (2006) (182)
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. (1995) (181)
Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes. (1994) (180)
Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival. (1993) (178)
Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses (1998) (177)
BAG‐1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release (1998) (176)
Oncogenic potential of bcl-2 demonstrated by gene transfer (1988) (176)
Ionomycin-activated Calpain Triggers Apoptosis (2002) (176)
Heterodimerization-independent Functions of Cell Death Regulatory Proteins Bax and Bcl-2 in Yeast and Mammalian Cells* (1997) (175)
Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. (1996) (174)
Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line (1992) (172)
Bax is a transcriptional target and mediator of c-myc-induced apoptosis. (2000) (172)
The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor κB Activation Pathways (2002) (172)
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. (2003) (172)
A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. (1996) (172)
Bcl-G, a Novel Pro-apoptotic Member of the Bcl-2 Family* (2001) (171)
Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons. (1996) (168)
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. (2003) (168)
Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. (2005) (168)
Dysregulation of apoptosis genes in hematopoietic malignancies (2002) (167)
Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo. (1996) (167)
A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. (2013) (166)
COP, a Caspase Recruitment Domain-containing Protein and Inhibitor of Caspase-1 Activation Processing* (2001) (165)
Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. (1997) (165)
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. (2017) (165)
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury. (2006) (164)
Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases* (2006) (163)
TNFR-Associated Factor Family Protein Expression in Normal Tissues and Lymphoid Malignancies (2000) (162)
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. (2004) (160)
Identification and Characterization of a Novel Bacterial Virulence Factor That Shares Homology with Mammalian Toll/Interleukin-1 Receptor Family Proteins (2006) (160)
The anti‐apoptotic genes Bcl‐XL and Bcl‐2 are over‐expressed and contribute to chemoresistance of non‐proliferating leukaemic CD34+ cells (2002) (159)
Lymphotoxin-β receptor signaling complex: Role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB (1997) (159)
Expression of bcl-2 and the progression of human and rodent prostatic cancers. (1996) (158)
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells (2001) (158)
BIRinging Chromosomes through Cell Division—And Survivin' the Experience (2000) (156)
Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines. (1994) (156)
A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity (2015) (156)
Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene. (2001) (156)
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl- 2 suppressible mechanism (1995) (155)
Molecular biology of chronic lymphocytic leukemia. (1998) (155)
Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression. (1986) (155)
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. (2010) (154)
Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. (2002) (154)
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt (2006) (154)
Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth (2007) (153)
Molecular basis for CD40 signaling mediated by TRAF3. (2000) (153)
BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense. (1990) (152)
Evolutionally conserved plant homologue of the Bax Inhibitor‐1 (BI‐1) gene capable of suppressing Bax‐induced cell death in yeast 1 (1999) (151)
CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain (2011) (151)
Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells. (1993) (151)
Apoptotic Protease Activating Factor 1 (Apaf-1)–Independent Cell Death Suppression by Bcl-2 (2000) (150)
Activation of CPP32 during apoptosis of neurons and astrocytes (1997) (150)
Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. (2003) (150)
The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex (2009) (150)
Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases (2012) (150)
PAN1/NALP2/PYPAF2, an Inducible Inflammatory Mediator That Regulates NF-κB and Caspase-1 Activation in Macrophages* (2004) (149)
Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo. (2000) (148)
Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin. (1997) (147)
PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. (2001) (146)
Immunohistochemical analysis of Bcl-2 family proteins in adenocarcinomas of the stomach. (1996) (145)
Apoptotic and Anti‐Apoptotic Mechanisms Following Spinal Cord Injury (2001) (144)
Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system (2002) (144)
Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. (1997) (144)
Granzyme Release and Caspase Activation in Activated Human T-Lymphocytes* (1998) (141)
Rational Design and Real Time, In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL (2004) (141)
The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer. (2002) (141)
The anti‐apoptotic protein BAG‐3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines (2001) (139)
Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation (2011) (139)
Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: glandular epithelial cell apoptosis is associated with increased expression of bax. (1997) (138)
The CARD plays a critical role in ASC foci formation and inflammasome signalling. (2013) (137)
Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1* (2008) (136)
Role of antioxidants and intracellular free radicals in retinamide-induced cell death. (1997) (135)
Differential effects of Bcl-2 on T and B cells in transgenic mice. (1992) (135)
Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24 (2003) (135)
Differential Regulation of Bax, Bcl‐2, and Bcl‐X Proteins in Focal Cortical Ischemia in the Rat (1998) (134)
The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells (2004) (133)
Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation. (1985) (132)
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. (2005) (131)
Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. (2000) (131)
Interaction of BAG-1 with Retinoic Acid Receptor and Its Inhibition of Retinoic Acid-induced Apoptosis in Cancer Cells* (1998) (130)
Testis-Specific Cytochrome c-Null Mice Produce Functional Sperm but Undergo Early Testicular Atrophy (2002) (130)
Vaccinia virus N1L protein resembles a B cell lymphoma‐2 (Bcl‐2) family protein (2006) (130)
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells (2005) (130)
Salmonella Secreted Factor L Deubiquitinase of Salmonella typhimurium Inhibits NF-κB, Suppresses IκBα Ubiquitination and Modulates Innate Immune Responses1 (2008) (130)
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. (2005) (129)
Caspases 3 and 9 Send a Pro-Apoptotic Signal from Synapse to Cell Body in Olfactory Receptor Neurons (2001) (127)
Non-apoptotic role of BID in inflammation and innate immunity (2011) (127)
Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak* (2005) (127)
Bcl-2 family proteins: strategies for overcoming chemoresistance in cancer. (1997) (126)
Anti-cell death activity promotes pulmonary metastasis of melanoma cells (1997) (126)
Bcl-B, a Novel Bcl-2 Family Member That Differentially Binds and Regulates Bax and Bak* (2001) (125)
Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells. (1996) (125)
Age-Associated Cardiac Dysfunction in Drosophila melanogaster (2001) (124)
Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary (1998) (124)
Postmitochondrial regulation of apoptosis during heart failure. (1999) (124)
Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line. (1994) (124)
Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1* (2009) (123)
Comparative analysis of apoptosis and inflammation genes of mice and humans. (2003) (123)
Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells (1998) (123)
Apoptosis in gastric epithelial cells is induced by Helicobacter pylori and accompanied by increased expression of BAK. (1997) (122)
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. (2006) (122)
Bax Inhibitor-1 Regulates Endoplasmic Reticulum Stress-associated Reactive Oxygen Species and Heme Oxygenase-1 Expression* (2007) (121)
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (2005) (121)
Bcl-2 and Bax Exert Opposing Effects on Ca2+ Signaling, Which Do Not Depend on Their Putative Pore-forming Region* (2004) (121)
Cooperative Interception of Neuronal Apoptosis by BCL‐2 and BAG‐1 Expression: Prevention of Caspase Activation and Reduced Production of Reactive Oxygen Species (1997) (120)
Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines. (1998) (119)
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes (2015) (118)
Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome. (2002) (116)
Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. (2015) (116)
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24–mediated toxicity (2011) (114)
BI-1 Regulates Endoplasmic Reticulum Ca2+ Homeostasis Downstream of Bcl-2 Family Proteins* (2008) (114)
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding (2018) (114)
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses (2007) (114)
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. (1993) (113)
Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax(*) (1995) (112)
Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis. (2002) (112)
Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity (2002) (112)
TUCAN, an Antiapoptotic Caspase-associated Recruitment Domain Family Protein Overexpressed in Cancer* (2001) (111)
Detection of multiple antigens on western blots. (1996) (111)
Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation* (1999) (111)
Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance* (2009) (110)
BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (2010) (110)
Bax Inhibitor-1 Is a pH-dependent Regulator of Ca2+ Channel Activity in the Endoplasmic Reticulum* (2008) (109)
Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice. (1996) (109)
Bcl-2 blocks degranulation but not fas-based cell-mediated cytotoxicity. (1995) (108)
BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer. (2001) (108)
Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation. (2008) (108)
Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia. (1996) (107)
Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. (2002) (107)
Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes. (1996) (107)
Nitric oxide induced poly(ADP‐ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl‐2 (1996) (107)
Discovery of a Viral NLR Homolog that Inhibits the Inflammasome (2011) (106)
Characterization of Interactions between the Anti-apoptotic Protein BAG-1 and Hsc70 Molecular Chaperones* (1998) (106)
Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. (1992) (106)
bcl‐2 and bak may play a pivotal role in sodium butyrate‐induced apoptosis in colonic epithelial cells; however overexpression of bcl‐2 does not protect against bak‐mediated apoptosis (1997) (105)
Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia (2002) (105)
Drug discovery opportunities from apoptosis research. (2000) (105)
Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species. (2003) (105)
Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cells. (1996) (105)
BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. (1993) (104)
Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium. (2000) (104)
Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms. (2000) (103)
CADD, a Chlamydia Protein That Interacts with Death Receptors* (2002) (103)
Interferon-γ Protects against Herpes Simplex Virus Type 1-Mediated Neuronal Death (1997) (102)
Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL* (2005) (102)
Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL (2003) (102)
BAG3 regulates motility and adhesion of epithelial cancer cells. (2007) (101)
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). (2006) (101)
Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6. (2004) (101)
Balancing cell life and death: bax, apoptosis, and breast cancer. (1996) (101)
Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein. (1994) (100)
Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn. (1992) (100)
Regulation of p53 Localization and Activity by Ubc13 (2006) (100)
ZIP Kinase Triggers Apoptosis from Nuclear PML Oncogenic Domains (2003) (99)
IL-18-producing Salmonella inhibit tumor growth (2008) (99)
Cloning and disruption of CKB1, the gene encoding the 38-kDa beta subunit of Saccharomyces cerevisiae casein kinase II (CKII). Deletion of CKII regulatory subunits elicits a salt-sensitive phenotype. (1995) (99)
Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection (2002) (98)
Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth (2009) (98)
Expression of Bcl-2 family member Bid in normal and malignant tissues. (2002) (98)
Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues. (1995) (97)
Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7. (1998) (97)
Acidic pH promotes dimerization of Bcl-2 family proteins. (1998) (96)
Predominant expression of the long isoform of Bcl‐x (Bcl‐xL) in human lymphomas (1996) (96)
PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2 (2003) (96)
Keratinocytes enriched for stem cells are protected from anoikis via an integrin signaling pathway in a Bcl‐2 dependent manner (2002) (96)
Investigations of antisense oligonucleotides targeted against bcl-2 RNAs. (1993) (95)
A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins (2001) (95)
Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers (2005) (95)
Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines (2001) (95)
Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection (2012) (94)
Finally, An Apoptosis-Targeting Therapeutic for Cancer. (2016) (94)
Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. (1992) (94)
Cellular, Biochemical, and Genetic Analysis of Mechanism of Small Molecule IAP Inhibitors* (2004) (94)
A cis-acting element in the BCL-2 gene controls expression through translational mechanisms. (1996) (92)
Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex* (2005) (92)
Expression of apoptosis regulatory proteins of the Bcl-2 family and p53 in primary resected non-small-cell lung cancer (1999) (92)
ChlaDub1 of Chlamydia trachomatis suppresses NF‐κB activation and inhibits IκBα ubiquitination and degradation (2008) (92)
Immunolocalization of the ICE/Ced-3–Family Protease, CPP32 (Caspase-3), in Non-Hodgkin's Lymphomas, Chronic Lymphocytic Leukemias, and Reactive Lymph Nodes (1997) (91)
Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1. (1997) (91)
Inactivation of Caspase-8 on Mitochondria of Bcl-xL-expressing MCF7-Fas Cells (2002) (91)
Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein (2007) (91)
Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy (2018) (90)
The Putative Pore-Forming Domain of Bax Regulates Mitochondrial Localization and Interaction with Bcl-XL (2000) (90)
Differential Effects of the hsp70-binding Protein BAG-1 on Glucocorticoid Receptor Folding by the hsp90-based Chaperone Machinery* (1999) (90)
Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules. (2004) (90)
Mechanisms of mitochondrial membrane permeabilization (2000) (89)
Inhibition of Tumor Growth Using Salmonella Expressing Fas Ligand (2008) (89)
Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2. (1997) (89)
Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization (2009) (89)
Cellular Pyrin Domain-Only Protein 2 Is a Candidate Regulator of Inflammasome Activation (2006) (89)
A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells. (1998) (89)
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. (2012) (88)
p53 Suppresses the c-Myb-induced Activation of Heat Shock Transcription Factor 3* (2000) (88)
A Novel PAAD-containing Protein That Modulates NF-κB Induction by Cytokines Tumor Necrosis Factor-α and Interleukin-1β* (2002) (88)
A Shope Fibroma virus PYRIN-only protein modulates the host immune response (2007) (88)
Bcl-2 family proteins: regulators of chemoresistance in cancer. (1995) (87)
Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors (2004) (87)
Mechanisms of Bcl-2 family protein function and dysfunction in health and disease. (1996) (87)
Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target. (2001) (87)
Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2 (2006) (87)
Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2. (1995) (87)
The Tumor Suppressor PTEN Regulates T Cell Survival and Antigen Receptor Signaling by Acting as a Phosphatidylinositol 3-Phosphatase1 (2000) (85)
Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy. (2004) (85)
Apoptosis mechanisms: implications for cancer drug discovery. (2004) (84)
Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor DR5 Is Regulated by the Death Effector Domain of FADD* (2004) (84)
Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools (2002) (83)
Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma. (1995) (83)
TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. (2004) (83)
HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis. (2006) (83)
Increased intestinal Bak expression results in apoptosis. (1996) (83)
Sunburned skin activates inflammasomes. (2008) (83)
Blockade of frontocortical-brain stem pathway prevents ventricular fibrillation of ischemic heart. (1981) (83)
Human intestinal epithelial cell survival: differentiation state-specific control mechanisms. (2001) (83)
Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid (2006) (82)
Image Analysis Algorithms for Immunohistochemical Assessment of Cell Death Events and Fibrosis in Tissue Sections (2009) (82)
Phosphorylation of calmodulin by the catalytic subunit of casein kinase II is inhibited by the regulatory subunit. (1993) (82)
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. (2010) (82)
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation (2013) (81)
Functional blocks in caspase activation pathways are common in leukemia and predict patient response to induction chemotherapy. (2003) (81)
The PYRIN domain – only protein POP 3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses (2014) (81)
Functional interaction of Fas‐associated phosphatase‐1 (FAP‐1) with p75NTR and their effect on NF‐κB activation (1999) (80)
In vivo patterns of Bcl‐2 family protein expression in breast carcinomas in relation to apoptosis (1999) (80)
Prognostic significance of Bax protein expression in diffuse aggressive non-Hodgkin's lymphoma. (1997) (79)
Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. (2004) (79)
TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. (1998) (79)
Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1. (2001) (79)
Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat (1996) (79)
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. (2007) (77)
Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy (2011) (77)
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases (2008) (77)
Three-dimensional structure of Bax-mediated pores in membrane bilayers (2013) (77)
CLAN, a novel human CED-4-like gene. (2001) (77)
Analysis of gene expression patterns during glucocorticoid-induced apoptosis using oligonucleotide arrays. (2002) (77)
Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. (2007) (76)
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. (2006) (76)
Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line. (1992) (76)
Key Molecular Contacts Promote Recognition of the BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation1 (2004) (75)
Bcl-2 protein localizes to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines. (1994) (75)
Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat. (2003) (75)
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis. (2005) (75)
Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses. (2008) (75)
Apoptosis and cancer: When BAX is TRAILing away (2002) (75)
Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration. (1996) (74)
The PYRIN domain-only protein POP3 inhibits AIM2-like receptor inflammasomes and regulates responses to DNA virus infections (2014) (74)
Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: evidence for a novel mechanism of regulating Bcl-2 family protein function. (1995) (73)
Activation of the CAMP signaling pathway increases apoptosis in human B‐precursor cells and is associated with downregulation of Mcl‐1 expression (1998) (73)
Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families. (2001) (73)
Bcl-2 and apoptosis in chronic lymphocytic leukemia (2003) (73)
ATG4B (Autophagin-1) Phosphorylation Modulates Autophagy* (2015) (72)
Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte (1985) (72)
Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53. (1997) (72)
Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. (2008) (72)
The C-terminal Tails of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas Receptors Have Opposing Functions in Fas-associated Death Domain (FADD) Recruitment and Can Regulate Agonist-specific Mechanisms of Receptor Activation* (2004) (71)
Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins (2008) (71)
The PYRIN Connection: Novel Players in Innate Immunity and Inflammation (2004) (71)
Interaction of Hepatitis B Viral Oncoprotein with Cellular Target HBXIP Dysregulates Centrosome Dynamics and Mitotic Spindle Formation* (2008) (70)
Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis. (1996) (70)
Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions (1999) (70)
Mechanisms of Bcl-2 protein function. (1998) (70)
Effect of p21waf1/cip1 transgene on radiation induced apoptosis in T cells (1999) (70)
BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity. (2008) (69)
Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis (1994) (69)
BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments (2008) (69)
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer. (2001) (69)
A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes. (1997) (69)
Differentiation-Dependent Expression of the BCL-2 Proto-Oncogene in the Human Trophoblast Lineage (1994) (69)
Peptides Targeting Caspase Inhibitors* (2003) (68)
Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death (2008) (68)
High expression of the bcl-x gene in Reed-Sternberg cells of Hodgkin's disease. (1995) (68)
The Retinoblastoma Protein Binds the Promoter of the Survival Gene bcl-2 and Regulates Its Transcription in Epithelial Cells through Transcription Factor AP-2 (2002) (67)
Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury (2011) (66)
Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel (2004) (66)
TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis* (2001) (66)
Bag1 is a regulator and marker of neuronal differentiation (2002) (66)
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer. (2008) (65)
Cytoprotection by Bcl-2 Requires the Pore-forming α5 and α6 Helices* (1998) (65)
Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid. (1997) (65)
Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine. (2010) (65)
Structurally Distinct Recognition Motifs in Lymphotoxin-β Receptor and CD40 for Tumor Necrosis Factor Receptor-associated Factor (TRAF)-mediated Signaling* (2003) (65)
Yeast as a tool for apoptosis research. (1999) (64)
Effects of environmental estrogens on tumor necrosis factor α-mediated apoptosis in MCF-7 cells (1999) (64)
Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation. (1997) (63)
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). (2004) (63)
Temporal and spatial profile of caspase 8 expression and proteolysis after experimental traumatic brain injury (2001) (62)
hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. (2000) (62)
Interaction of BAG1 and Hsp70 Mediates Neuroprotectivity and Increases Chaperone Activity (2005) (62)
Functional Role of Death-associated Protein 3 (DAP3) in Anoikis* (2004) (62)
The Drosophila Tumor Necrosis Factor Receptor-associated Factor-1 (DTRAF1) Interacts with Pelle and Regulates NFκB Activity* (2000) (61)
Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. (1997) (61)
The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor β-Dependent Apoptosis in Breast Cancer (2004) (61)
Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia. (2000) (61)
Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment (1998) (60)
Reciprocal negative regulation between S100A7/psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity (2008) (60)
Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers. (1997) (60)
Investigation of glucocorticoid-induced apoptotic pathway: Processing of Caspase-6 but not Caspase-3 (1998) (60)
Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo (2003) (60)
The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. (1996) (60)
FLIP protein and TRAIL-induced apoptosis. (2004) (60)
Frequent expression of the cell death-inducing gene Bax in Reed-Sternberg cells of Hodgkin's disease. (1996) (60)
CARD6 Is a Modulator of NF-κB Activation by Nod1- and Cardiak-mediated Pathways* (2003) (59)
High-Throughput Fluorescence Assay for Small-Molecule Inhibitors of Autophagins/Atg4 (2011) (59)
BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion. (2010) (58)
Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands (2010) (58)
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies (2005) (58)
AACR Cancer Progress Report 2013 (2013) (58)
COGNITIVE, PSYCHOMOTOR, AND MOTOR CORRELATES OF MULTIPLE SCLEROSIS (1971) (58)
LMP1 Protein from the Epstein-Barr Virus Is a Structural CD40 Decoy in B Lymphocytes for Binding to TRAF3* (2005) (58)
Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain* (1999) (58)
Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint. (2006) (58)
A multivariate analysis of tumour biological factors predicting response to cytotoxic treatment in advanced breast cancer. (1998) (58)
TRAF1: Lord Without A RING (2002) (57)
BAG1L Enhances Trans-activation Function of the Vitamin D Receptor* (2000) (57)
Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies (2008) (57)
Interferon-gamma protects against herpes simplex virus type 1-mediated neuronal death. (1997) (57)
Cloning and disruption of CKB2, the gene encoding the 32-kDa regulatory beta'-subunit of Saccharomyces cerevisiae casein kinase II. (1994) (57)
Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family. (1997) (56)
Inhibition of ceramide-induced apoptosis by Bcl-2. (1995) (56)
Promise and problems of Bcl-2 antisense therapy. (1997) (56)
Expression of the cell death-inducing gene bax in carcinomas developed from the follicular cells of the thyroid gland. (1996) (56)
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins (2009) (56)
Fascicular and Nonfascicular Left Ventricular Tachycardias in the Young: An International Multicenter Study (2013) (56)
A Well-Kept Treasure at Depth: Precious Red Coral Rediscovered in Atlantic Deep Coral Gardens (SW Portugal) after 300 Years (2016) (55)
Bcl‐2, Raf‐1 and mitochondrial regulation of apoptosis (1998) (55)
Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein. (1995) (55)
Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity (2011) (55)
Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB. (2006) (55)
Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells. (1993) (54)
Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration (2012) (54)
Tissue-Specific Immunoregulation: A Call for Better Understanding of the "Immunostat" in the Context of Cancer. (2018) (54)
Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner (2004) (54)
Structure-Function Analysis of Bag1 Proteins (2001) (54)
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (2009) (54)
Immunodetection of apoptosis-regulating proteins in lymphomas from patients with and without human immunodeficiency virus infection. (1996) (54)
Conformation of Membrane-associated Proapoptotic tBid* (2004) (54)
Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (2002) (53)
Apoptosis in Xenopus tadpole tail muscles involves Bax‐dependent pathways (1997) (53)
Therapeutics targeting Bcl-2 in hematological malignancies. (2017) (53)
BAG-1 accelerates cell motility of human gastric cancer cells (1999) (53)
Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer. (2009) (53)
Molecular Mimicry in Innate Immunity (2009) (53)
Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori. (2001) (53)
ARTS and Siah collaborate in a pathway for XIAP degradation. (2011) (52)
BAG1 Over‐expression in Brain Protects Against Stroke (2003) (52)
Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways (2003) (52)
Bcl-x1 Bax Interaction after Transient Global Ischemia (1998) (52)
Cytokine-mediated survival from lethal herpes simplex virus infection: role of programmed neuronal death. (1995) (52)
Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells. (2002) (52)
Ironing Out Cell Death Mechanisms (2012) (51)
Nuclear localization of procaspase-9 and processing by a caspase-3-like activity in mammary epithelial cells. (2000) (51)
Resistance to apoptosis and up regulation of Bcl-2 in benign prostatic hyperplasia after androgen deprivation. (1997) (51)
Dysregulation of Receptor Interacting Protein-2 and Caspase Recruitment Domain Only Protein Mediates Aberrant Caspase-1 Activation in Huntington's Disease (2005) (51)
Cyclin B1/Cdk1 Phosphorylation of Mitochondrial p53 Induces Anti-Apoptotic Response (2010) (51)
Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein* (2013) (51)
Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging (2013) (51)
Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs (2013) (50)
Absence of t(14;18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease. (1991) (50)
Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations (1997) (50)
Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis (2007) (50)
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. (2003) (50)
Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts (1990) (50)
Expression of caspase‐3 in brains from paediatric patients with HIV‐1 encephalitis (1999) (49)
Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. (1996) (49)
Targeting TRAfs for therapeutic intervention. (2007) (49)
Survivin’ cell-separation anxiety (1999) (49)
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress (2015) (48)
The Mitochondrial F 0 F 1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells (1998) (47)
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation (2011) (47)
PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells. (2014) (47)
Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors. (2008) (47)
Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines (2004) (46)
The PYRIN Connection (2004) (46)
Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. (2011) (46)
Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells. (1994) (46)
The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1. (2001) (46)
Chronic Ureteral Obstruction in the Rat Suppresses Renal Tubular Bcl-2 and Stimulates Apoptosis (2000) (46)
Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway. (2005) (46)
Molecular biology of chronic lymphocytic leukemia: implications for therapy. (1998) (46)
Expression of pro‐ and anti‐apoptosis gene products in brains from paediatric patients with HIV‐1 encephalitis (1997) (45)
A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. (2002) (45)
The role of the accessory cell in mitogen-stimulated human T cell gene expression. (1986) (45)
The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. (1997) (45)
Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. (1996) (45)
Vaccinia Virus Protein F1L Is a Caspase-9 Inhibitor* (2009) (45)
Enhanced delivery of mda‐7/IL‐24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the apogossypol derivative BI‐97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells (2012) (45)
BCL-2 expression correlates with lower proliferative activity in the intermediate- and high-grade non-Hodgkin's lymphomas: an Eastern Cooperative Oncology Group and Southwest Oncology Group cooperative laboratory study. (1998) (45)
Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells (2001) (44)
Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers. (1999) (44)
Regulation of bcl-2 gene expression in lymphoid cell lines containing normal #18 or t(14;18) chromosomes. (1989) (43)
Structural Analysis of Siah1 and Its Interactions with Siah-interacting Protein (SIP)* (2003) (43)
CARD proteins as therapeutic targets in cancer. (2004) (43)
Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin (1998) (43)
Structure of the Chlamydia Protein CADD Reveals a Redox Enzyme That Modulates Host Cell Apoptosis* (2004) (43)
Apotosis-related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix. (2002) (42)
An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins (2011) (42)
BCIRG 001 Molecular Analysis: Prognostic Factors in Node-Positive Breast Cancer Patients Receiving Adjuvant Chemotherapy (2010) (42)
Suppression of human fibrosarcoma cell growth by transcription factor, Egr‐1, involves down‐regulation of Bcl‐2 (1998) (42)
Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines. (2001) (42)
Cellular FLIP Inhibits β-Catenin Ubiquitylation and Enhances Wnt Signaling (2004) (41)
Effects of organ culture and Optisol-GS storage on structural integrity, phenotypes, and apoptosis in cultured corneal epithelium. (2007) (41)
Structural and Functional Analysis of the NLRP4 Pyrin Domain (2012) (41)
Verbal and Performance Differences among Brain-Injured Children with Lateralized Motor Deficits (1969) (41)
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis (1996) (41)
Intranasal insulin treatment of an experimental model of moderate traumatic brain injury (2017) (41)
Structural studies of apoptosis and ion transport regulatory proteins in membranes (2004) (40)
Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death. (2000) (40)
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (2007) (40)
Early establishment of epithelial apoptosis in the developing human small intestine. (2000) (39)
Expression of BAG-1 and BcL-2 Proteins Before and After Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer (2004) (39)
Zircon Ages of Felsic Volcanic Rocks in the Upper Precambrian of the Blue Ridge, Appalachian Mountains (1969) (39)
Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein. (1992) (39)
Expression of apoptotic regulators and their significance in cervical cancer. (2002) (39)
Bcl-2 acts upstream of the PARP protease and prevents its activation (1997) (39)
Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. (1991) (39)
Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression. (1993) (39)
A day in the life of the Bcl-2 protein: does the turnover rate of Bcl-2 serve as a biological clock for cellular lifespan regulation? (1996) (39)
Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma. (1996) (38)
BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma. (2000) (38)
The FLIP-Side of Fas Signaling (2006) (38)
Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer. (2012) (38)
Interleukin-1-beta gene expression in human monocytes and alveolar macrophages from normal subjects and patients with sarcoidosis. (1988) (38)
ATP‐activated oligomerization as a mechanism for apoptosis regulation: Fold and mechanism prediction for CED‐4 (2000) (37)
Temporal and Spatial Profile of Bid Cleavage after Experimental Traumatic Brain Injury (2002) (37)
Functional properties of the 50 kd protein associated with the E-receptor on human T lymphocytes: suppression of IL 2 production by anti-p50 monoclonal antibodies. (1985) (37)
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation (2009) (37)
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (2010) (37)
CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. (2003) (37)
Differential sensitivity to apoptosis between the human small and large intestinal mucosae: Linkage with segment‐specific regulation of Bcl‐2 homologs and involvement of signaling pathways * (2001) (37)
Immunolocalization of the ICE/Ced-3-family protease, CPP32 (Caspase-3), in non-Hodgkin's lymphomas, chronic lymphocytic leukemias, and reactive lymph nodes. (1997) (37)
Suppression of interleukin 2 receptor acquisition by monoclonal antibodies recognizing the 50 KD protein associated with the sheep erythrocyte receptor on human T lymphocytes. (1985) (37)
Identification and Characterization of DEDD2, a Death Effector Domain-containing Protein* (2002) (37)
Bag‐1 and Bcl‐2 Gene Transfer in Malignant Glioma: Modulation of Cell Cycle Regulation and Apoptosis (2000) (37)
30 KDa phosphorylated form of Bcl-2 protein in human colon. (1996) (36)
Apoptosis Induction by 1,25-Dihydroxyvitamin D 3 in Prostate Cancer 1 (2002) (36)
Expression of BAG‐1 protein correlates with aggressive behavior of prostate cancers (2006) (36)
Antisense oligodeoxynucleotides to bax mRNA promote survival of rat sympathetic neurons in culture (1996) (36)
Geologic map of Grand Teton National Park, Teton County, Wyoming (1992) (36)
Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress* (2010) (36)
p53 gene status and chemosensitivity of childhood acute lymphoblastic leukemia cells to adriamycin. (1999) (36)
Characterization of the anti-apoptotic mechanism of Bcl-B. (2003) (35)
Effect of wheat germ agglutinin on the interleukin pathway of human T lymphocyte activation. (1985) (35)
Regulation of p26-bcl-2 protein levels in human peripheral blood lymphocytes. (1992) (35)
TR-FRET-Based High-Throughput Screening Assay for Identification of UBC13 Inhibitors (2012) (35)
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain. (1996) (35)
Multiple Roles of CLAN (Caspase-Associated Recruitment Domain, Leucine-Rich Repeat, and NAIP CIIA HET-E, and TP1-Containing Protein) in the Mammalian Innate Immune Response1 (2004) (35)
Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases (2013) (35)
MCL-1 promoter insertions dial-up aggressiveness of chronic leukemia. (2004) (34)
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE 1 a (2009) (34)
Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT. (1991) (34)
Triterpenoids Display Single Agent Anti-tumor Activity in a Transgenic Mouse Model of Chronic Lymphocytic Leukemia and Small B Cell Lymphoma (2007) (34)
Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line. (1993) (34)
PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. (1996) (33)
Role of bcl-2 and IL-5 in the regulation of anti-IgM-induced growth arrest and apoptosis in immature B cell lines. A cooperative regulation model for B cell clonal deletion. (1994) (33)
Claudin‐1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate (2007) (33)
Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line. (1994) (33)
Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member. (2012) (33)
Apoptosis and Bcl-2 expression in cultured murine splenic T cells. (1995) (33)
Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. (2001) (32)
Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia. (1997) (32)
Bcl-2, Bax and Bcl-x expression in neuronal apoptosis: a study of mutant weaver and lurcher mice (1998) (32)
Immunohistochemical analysis of interleukin-1β-converting enzyme/ced-3 family protease, CPP32/Yama/caspase-3, in Hodgkin's disease (1997) (32)
Modulating apoptosis pathways in low-grade B-cell malignancies using biological response modifiers. (2002) (32)
Siah1/SIP regulates p27kip1 stability and cell migration under metabolic stress (2011) (32)
Induction of mammalian cell death by a plant Bax inhibitor (2002) (31)
Characterization of a TIR-like protein from Paracoccus denitrificans. (2007) (31)
Activin A‐induced apoptosis is suppressed by BCL‐2 (1995) (31)
Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience (2011) (31)
Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: Cytochrome c Release in the Absence of Altered Expression of Bcl-2 Family Proteins (1998) (30)
Expression of p21 Protein Predicts Clinical Outcome in DLBCL Patients Older than 60 Years Treated with R-CHOP but not CHOP: A Prospective ECOG and Southwest Oncology Group Correlative Study on E4494 (2010) (30)
Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells. (1999) (30)
Bcl-2 and Bax expression in thyroid tumours An immunohistochemical and Western blot analysis (1997) (29)
BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival (2015) (29)
Sequential Cleavage of Poly(ADP‐Ribose)polymerase and Appearance of a Small Bax‐Immunoreactive Protein Are Blocked by Bcl‐XL and Caspase Inhibitors During Staurosporine‐Induced Dopaminergic Neuronal Apoptosis (1999) (29)
BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution (2009) (29)
Bcl-2 family proteins and the hormonal control of cell life and death in normalcy and neoplasia. (1997) (28)
TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-κB (2009) (28)
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. (2011) (28)
Proto-oncogene expression in cloned T lymphocytes: mitogens and growth factors induce different patterns of expression. (1987) (28)
Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling (2013) (28)
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. (2013) (27)
Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. (1996) (27)
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling. (2004) (27)
Differential promoter utilization by the c-myc gene in mitogen- and interleukin-2-stimulated human lymphocytes (1987) (27)
Prolactin-regulated apoptosis of Nb2 lymphoma cells (1998) (27)
BAG-1 inhibits p53-induced but not apoptin-induced apoptosis (2004) (27)
Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists. (2009) (27)
Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells (2007) (26)
Bax accelerates staurosporine‐induced but suppresses nigericin‐induced neuronal cell death (1997) (26)
HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2 (2015) (26)
Exploration of Naval Petroleum Reserve No. 4 and adjacent areas, northern Alaska, 1944-53; Part 1, History of the exploration (1958) (26)
Bcl-2 on the brink of breakthroughs in cancer treatment (2017) (26)
Bax inhibitor-1 protects neurons from oxygen-glucose deprivation (2007) (25)
Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein. (1999) (25)
Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction. (1993) (25)
Immunohistochemical Analysis of bc1–2, bax, mcl‐1, and bc1‐X Expression in Ovarian Surface Epithelial Tumors (1998) (25)
Anti-apoptotic genes, bag-1 and bcl-2, enabled hybridoma cells to survive under treatment for arresting cell cycle (2004) (25)
Mice lacking bi-1 gene show accelerated liver regeneration. (2007) (25)
Nuclear BAG-1 localization and the risk of recurrence after radiation therapy in laryngeal carcinomas. (2001) (25)
Caspases and cytokines: roles in inflammation and autoimmunity. (1999) (25)
Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia (2017) (25)
Estrogen withdrawal‐induced human breast cancer tumour regression in nude mice is prevented by Bcl‐2 (1998) (25)
Correlation Between Structure of Bcl‐2 and Its Inhibitory Function of JNK and Caspase Activity in Dopaminergic Neuronal Apoptosis (2000) (25)
Impairment of the ubiquitin‐proteasome system by cellular FLIP (2007) (25)
Co‐chaperone BAG3 and adenovirus penton base protein partnership (2010) (24)
Bcl-2 on the brink of breakthroughs in cancer treatment. (2018) (24)
Enhanced Prostate Cancer Gene Transfer and Therapy Using a Novel Serotype Chimera Cancer Terminator Virus (Ad.5/3‐CTV) (2013) (24)
Deregulated BCL2 expression enhances growth of a human B cell line. (1989) (24)
Inhibition of Bfl-1 with N-aryl maleimides. (2010) (24)
Effects of modulators of protein kinases on taxol-induced apoptosis of human leukemic cells possessing disparate levels of p26BCL-2 protein. (1995) (24)
CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1 (2012) (24)
Sex-dependent Effect of BAG1 in Ameliorating Motor Deficits of Huntington Disease Transgenic Mice* (2008) (24)
Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFbeta1-induced apoptosis in colorectal adenoma cells. (1998) (24)
Early acquisition of bowel segment-specific Bcl-2 homolog expression profiles during development of the human ileum and colon. (2001) (24)
Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes. (1991) (23)
NLRP1, a regulator of innate immunity associated with vitiligo (2012) (23)
PSYCHOLOGICAL STRESS REDUCES CYCLIC 3′,5′‐ADENOSINE MONOPHOSPHATE LEVELS IN THE CEREBRAL CORTEX OF CONSCIOUS RATS, AS DETERMINED BY A NEW CRYOGENIC METHOD OF RAPID TISSUE FIXATION 1 (1978) (23)
Bcl-2 relieves the trans-repressive function of the glucocorticoid receptor and inhibits the activation of CPP32-like cysteine proteases. (1997) (23)
CD40‐mediated activation of Ig‐Cγ1‐ and Ig‐Cϵ germ‐line promoters involves multiple TRAF family proteins (1999) (23)
High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1 (2012) (23)
Cell cycle analysis of p26-BCL-2 protein levels in proliferating lymphoma and leukemia cell lines. (1992) (23)
Transformed 3T3 cells have reduced levels and altered subcellular distribution of the major PKC substrate protein MARCKS. (1991) (23)
Methods of assaying Bcl-2 and Bax family proteins in yeast. (1999) (23)
Expression of c-myc proto-oncogene in normal human lymphocytes. Regulation by transcriptional and posttranscriptional mechanisms. (1987) (22)
Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. (2006) (22)
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis (2008) (22)
PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma (2014) (22)
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference (2006) (22)
Cancer immunotherapy targeting survivin: commentary re: V. Pisarev et al., full-length dominant-negative survivin for cancer immunotherapy. Clin. Cancer Res., 9:6523-6533, 2003. (2003) (22)
Bigger than Gallipoli: War, History and Memory in Australia (2004) (21)
Structural Determinants of Caspase-9 Inhibition by the Vaccinia Virus Protein, F1L* (2011) (21)
PCTAIRE1-Knockdown Sensitizes Cancer Cells to TNF Family Cytokines (2015) (21)
IFN-gamma upregulates anti-apoptotic gene expression and inhibits apoptosis in IL-3-dependent hematopoietic cells. (1997) (21)
Calendar life-span versus fission life-span of Paramecium aurelia. (1976) (20)
Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants (2012) (20)
Purification and characterization of the bcl-2 protein. (1994) (20)
The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling (2014) (20)
Modulating apoptosis pathways in low-grade B-cell malignancies using biological response modifiers. (2002) (20)
Fenretinide: the death of a tumor cell. (1999) (20)
Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules. (2012) (20)
Co-expression of bcl-2 and bag-1, apoptosis suppressing genes, prolonged viable culture period of hybridoma and enhanced antibody production (1999) (19)
Merosin (laminin‐2/4)‐driven survival signaling: Complex modulations of Bcl‐2 homologs (2003) (19)
BAG-1M, an isoform of Bcl-2-interacting protein BAG-1, enhances gene expression driven by CMV promoter. (2001) (19)
Anti-Apoptotic Bfl-1 Is the Major Effector in Activation-Induced Human Mast Cell Survival (2012) (19)
CUTANEOUS SHOCK PRODUCES CORRELATED SHIFTS IN SLOW POTENTIAL AMPLITUDE AND CYCLIC 3′,5′‐ADENOSINE MONOPHOSPHATE LEVEL IN THE PARIETAL CORTEX OF THE CONSCIOUS RAT 1 (1978) (19)
TNFR-Associated Factor 2 Deficiency in B Lymphocytes Predisposes to Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Mice (2012) (19)
Lecture Mechanisms of Apoptosis (2000) (18)
Splicing and dicing apoptosis genes (1999) (18)
Cysteine protease CPP32, but not Ich1-L, is expressed in germinal center B cells and their neoplastic counterparts. (1997) (18)
A strategy for generating monoclonal antibodies against recombinant baculovirus-produced proteins: application to the Bcl-2 oncoprotein. (1992) (18)
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. (2006) (18)
REGULATION OF GENE EXPRESSION IN LECTIN‐STIMULATED OR LYMPHOKINE‐STIMULATED T LYMPHOCYTES1 (1988) (18)
Relationship between nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia (B-CLL) and protein expression of Bcl-2, Bax, Bcl-X and p53. (1997) (17)
The NIH's role in accelerating translational sciences (2012) (17)
Precambrian geology of the U.S.A. (1987) (17)
Structure and function of Saccharomyces cerevisiae casein kinase II. (1994) (17)
Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines (2011) (17)
RIP2-beta: a novel alternative mRNA splice variant of the receptor interacting protein kinase RIP2. (2009) (17)
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis (2016) (16)
Expression of BAX in plasma cell dyscrasias. (2000) (16)
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in Teeth (1998) (16)
Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production. (1991) (16)
Phenotypic changes induced by interleukin-2 (IL-2) and IL-3 in an immature T-lymphocytic leukemia are associated with regulated expression of IL-2 receptor beta chain and of protein tyrosine kinases LCK and LYN. (1992) (16)
Miliary aspergillosis associated with alcoholism. (1978) (16)
Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators (2009) (16)
Protein tyrosine kinase p56-Lck regulates lymphocyte function-associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell. (1994) (16)
Habitat Characterization, Distribution, and Areal Extent of Deep-sea Coral Ecosystems off Florida, Southeastern U.S.A. (2013) (16)
Monoclonal antibody OKT11A inhibits and recombinant interleukin 2 (IL 2) augments expression of IL 2 receptors at a pretranslational level. (1985) (16)
Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. (2011) (16)
Expression of the human BCL‐2 transgene increases the radiation resistance of a hematopoietic progenitor cell line (1994) (16)
Mini-Review: Cellular Mechanisms of Disease Series Bcl-2 and the Regulation of Programmed Cell Death (1994) (16)
Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice (2019) (15)
Crystal structure of PqqC from Klebsiella pneumoniae at 2.1 Å resolution (2004) (15)
Bcl-x gene expression in Hodgkin's disease. (1996) (15)
bcl-2 alters the antigen-driven selection of B cells in mukappa but not in mu-only Xid transgenic mice. (1996) (15)
Establishing apoptosis resistant cell lines for improving protein productivity of cell culture (2004) (15)
Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules (2010) (15)
Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics (1997) (15)
Mapping the Specific Cytoprotective Interaction of Humanin with the Pro‐apoptotic Protein Bid (2007) (15)
Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins* (2016) (15)
Derivation of a Retinoid X Receptor Scaffold from Peroxisome Proliferator‐Activated Receptor γ Ligand 1‐Di(1H‐indol‐3‐yl)methyl‐4‐trifluoromethylbenzene (2009) (15)
Robust lanthanide-based assays for the detection of anti-apoptotic Bcl-2-family protein antagonists. (2007) (14)
Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors. (2000) (14)
A High-Content Screening (HCS) Assay for the Identification of Chemical Inducers of PML Oncogenic Domains (PODs) (2011) (14)
Large Parallel UPS Systems Utilizing PWM Technology (1984) (14)
Novel pan‐neuronal Cre‐transgenic line for conditional ablation of genes in the nervous system (2005) (14)
Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. (1996) (14)
Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C. (2010) (14)
Soluble inhibitors of T lymphocyte proliferation: Tools for dissecting pathways of T cell activation (1988) (14)
Measuring pore formation by Bcl-2 family proteins. (2000) (14)
Salicylate Regulates COX‐2 Expression Through ERK and Subsequent NF‐κB Activation in Osteoblasts (2004) (14)
Assays for studying Bax-induced lethality in the yeast Saccharomyces cerevisiae. (2000) (14)
G to A polymorphism in the second exon of the BCL2 gene. (1991) (14)
Characterization of the 13 q 14 Tumor Suppressor Locus in CLL : Identification of ALT 1 , an Alternative Splice Variant of the LEU 2 Gene 1 (2001) (14)
TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40. (2005) (13)
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. (2013) (13)
Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1G93A–transgenic mice (2008) (13)
Why do drugs work in CLL? (1996) (13)
A TR3/Nur77 Peptide-Based High-Throughput Fluorescence Polarization Screen for Small Molecule Bcl-B Inhibitors (2008) (13)
Subcellular distribution affects BAG1 function (2008) (12)
Heterocyclic alpha-helix mimetics for targeting protein-protein interactions. (2007) (12)
Role of bcl-2 in growth factor triggered signal transduction. (1990) (12)
Dual Agonist Surrobody Simultaneously Activates Death Receptors DR4 and DR5 to Induce Cancer Cell Death (2015) (12)
High Throughput Screening Assays for NOD1 Inhibitors - Probe 2 (2010) (12)
BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effectsin vitro andin vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases (1998) (12)
Roles of NOD 1 ( NLRC 1 ) and NOD 2 ( NLRC 2 ) in innate immunity and inflammatory diseases (2012) (12)
IL‐2‐induced gene expression of protein‐tyrosine phosphatase LC‐PTP requires acidic and serine‐rich regions within IL‐2 receptor β chain (1995) (12)
Benzodiazepinone Derivatives Protect against Endoplasmic Reticulum Stress-Mediated Cell Death in Human Neuronal Cell Lines (2014) (11)
Immunohistochemical analysis of interleukin-1beta-converting enzyme/Ced-3 family protease, CPP32/Yama/Caspase-3, in Hodgkin's disease. (1997) (11)
Gene transfer investigations of p56-LCK function in IL-2-dependent T-cell lines: implications for mechanisms of IL-2-signal transduction. (1992) (11)
Geologic map of the Quantico quadrangle, Prince William and Stafford Counties, Virginia, and Charles County, Maryland (1972) (11)
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines. (2012) (11)
Interleukin 4 inhibits IL-2-induced proliferation of a human T-leukemia cell line without interfering with p56-LCK kinase activation. (1992) (11)
Stimulation and inhibition of human T cell subsets by wheat germ agglutinin. (1985) (11)
Regulation of SRC-family protein tyrosine kinases by interleukins, IL-2, and IL-3. (1992) (11)
K63 ubiquitination in immune signaling (2022) (10)
Priming Cancer Cells for Death (2011) (10)
Inhibitor of apoptosis proteins (IAPS) (2001) (10)
The river and the rocks: The geologic story of Great Falls and the Potomac River Gorge (1970) (10)
Evaluation of Bcl-2/B cell transgenic mice (B6) for hybridoma production. (1996) (10)
Casein kinase II of Saccharomyces cerevisiae contains two distinct regulatory subunits, beta and beta'. (1994) (9)
Application of a PCR-mismatch technique to the BCL-2 gene: detection of point mutations in BCL-2 genes of malignancies with A t(14,18). (1992) (9)
Targeted therapy of AML new concepts. (2004) (9)
Molecular basis for CD 40 signaling mediated by TRAF 3 (2000) (9)
Detection of the cell death-inducing protein BAK in Reed-Sternberg cells of Hodgkin's disease. (1999) (9)
Modified VAD and PSC-833 in the treatment of resistant or relapsing chronic lymphocytic leukemia (E4996): a trial of the Eastern Cooperative Oncology Group. (2004) (9)
Induction and regulation of CD2 mRNA in human lymphocytes. (1988) (9)
Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1 (2015) (9)
Chapter 20 Studies of apoptosis proteins in yeast (2001) (8)
Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination (2016) (8)
Apoptosis in the Kidney (2011) (8)
Comparison of DR5 and Fas expression levels relative to the chemosensitivity of acute lymphoblastic leukemia cell lines. (2002) (8)
Correction: A Well-Kept Treasure at Depth: Precious Red Coral Rediscovered in Atlantic Deep Coral Gardens (SW Portugal) after 300 Years (2016) (8)
Preliminary structural studies on the leucine-zipper homology region of the human protein Bap31. (2007) (7)
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. (2004) (7)
IAPs and their emergent role in NLR signaling (2010) (7)
Modulation of the expression of Bcl-2 and related proteins in human leukemia cells by protein kinase C activators: relationship to effects on 1-[β-D-arabinofuranosyl]cytosine-induced apoptosis (1997) (7)
Chronic lymphocytic leukemia: A disease of dysregulated programmed cell death* (1997) (7)
Dissecting the in vivo leukemogenic potency of BCLxl. (2014) (7)
Arctic Laboratory. A History (1947-1966) of the Naval Arctic Research Laboratory at Point Barrow, Alaska (1971) (7)
Bag 1 Proteins Regulate Growth and Survival of ZR-751 Human Breast Cancer Cells 1 (2002) (7)
Fluorogenic substrates as detectors of caspase activity during natural killer cell-induced apoptosis. (2000) (7)
Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Effects of cyclosporine. (1988) (7)
Reconstituting the NLRP1 inflammasome in vitro. (2013) (6)
Cisplatin-induced Apoptosis of MCF-7 Breast Cancer Cells Caspase-3 Is Essential for Procaspase-9 Processing and Updated (2000) (6)
Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML) (2016) (6)
Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain. (2009) (6)
Crystalline rocks of the Potomac River Gorge near Washington, D.C. (1963) (6)
Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice (2012) (6)
Prolactin-stimulated X-linked inhibitor of apoptosis protein expression during S phase cell cycle progression in rat Nb2 lymphoma cells (2001) (6)
Regulation of apoptotic cell death within the trophoblast layer: Role of BCL-2, BAX, and BAK in the term human placenta (1998) (6)
Protooncogene-encoded protein kinases in interleukin-2 signal transduction. (1993) (6)
Response to 'Interaction of DAP3 and FADD only after cellular disruption' (2002) (5)
Ubiquitin-Conjugating Enzyme Ubc13 Is a Critical Component of TRAF-Mediated Inflammatory Responses. (2006) (5)
Differences in epithelial apoptosis and apoptosis-related gene expression between the rat small and large intestine (1995) (5)
CD40-mediated activation of Ig-Cgamma1- and Ig-cepsilon germ-line promoters involves multiple TRAF family proteins. (1999) (5)
Expression of Bcl-2-related genes in normal and AML progenitors (1999) (5)
Studies of apoptosis proteins in yeast. (2001) (5)
Cancer Immunotherapy Targeting Survivin (2003) (5)
bcl2 and v-abl oncogenes cooperate to immortalize murine B cells that secrete antigen specific antibodies. (1999) (5)
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway (2013) (5)
GX15–070MS, a synthetic small molecule induces apoptosis in vitro and in vivo in chronic lymphocytic leukemia (2005) (5)
Schubert - the final years (1972) (4)
Analysis of dimerization of Bcl-2 family proteins by surface plasmon resonance. (2000) (4)
Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity (2016) (4)
Butyrate-induced reversal of dexamethasone resistance in autonomous rat Nb2 lymphoma cells (2004) (4)
LMP 1 PROTEIN FROM THE EPSTEIN BARR VIRUS IS A STRUCTURAL CD 40 DECOY IN B LYMPHOCYTES FOR BINDING TO TRAF 3 * (2005) (4)
Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML (2015) (4)
In Vivo Patterns of Apoptosis-Regulating Protein Expression in Kaposi's Sarcoma (1997) (4)
The lymphokine "inhibitor of DNA synthesis" (IDS) suppresses human T lymphocyte proliferation by an interleukin-2-independent mechanism. (1986) (4)
Immunoexpression of Survivin in non-neoplastic lymphoid tissues and malignant lymphomas using a new monoclonal antibody reactive on paraffin sections (2010) (4)
Apoptosis and cell death. Foreword. (2008) (4)
Inhibitor of apoptosis proteins (2011) (4)
Sensitivity of mouse Skh:HR-2 to ultraviolet radiation: melanocyte inactivation. (1987) (4)
Cyclosporine A and bromocriptine attenuate cell death mediated by intracellular calcium mobilization. (2012) (4)
Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity (2018) (4)
A new algorithm for pick-and-place operation (2010) (4)
Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997 (2010) (4)
The Bcl-2/Bax ratio of lymphocytes from human systemic lupus erythematosus patients (1997) (4)
CHAPTER 7 – MECHANISMS OF INTERLEUKIN 2 ACTION: IL-2-INDUCIBLE GENE EXPRESSION IN T LYMPHOCYTES (1988) (4)
Yeast and mammalian two-hybrid systems for studying protein-protein interactions. (2007) (3)
Yeretssian et al. reply (2012) (3)
BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor (2011) (3)
Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2 (1998) (3)
Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples. (2004) (3)
Bax-induced cytochrome c release from mitochondria depends on α -helices-5 and -6 (2004) (3)
Expression of Bcl-2-related genes in normal and AML progenitors : changes induced by chemotherapy and retinoic acid : Apoptosis and Chemotherapy Resistance (1999) (3)
Advances in Brief bcl-2 Gene Transfer Increases Relative Resistance of S 49 . 1 and WEHI 7 . 2 Lymphoid Cells to Cell Death and DNA Fragmentation Induced by Glucocorticoids and Multiple Chemotherapeutic Drugsl (2006) (3)
Geology of the Lenoir quadrangle, North Carolina (1964) (3)
Geology of the Potsdam quadrangle (1934) (3)
Thoracic Duct Lymph Obstructioii by Sengstaken‐Blakemore Balloon Tamponade (1967) (3)
Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation (2015) (3)
Caspases and Their Natural Inhibitors as Therapeutic Targets for Regulating Apoptosis (2000) (3)
Apoptotic Signaling in Male Germ Cells (2011) (3)
Gait analysis in a rat model of traumatic brain injury (2021) (3)
1 SEX-DEPENDENT EFFECT OF BAG 1 IN AMELIORATING MOTOR DEFICITS OF HUNTINGTON ’ S DISEASE TRANSGENIC MICE (2008) (3)
Bcl-2 Family Proteins and the Dysregulation of Programmed Cell Death (2002) (2)
Community crystal gazing (2016) (2)
Response Protein ) in the Mammalian Innate Immune and NAIP CIIA HET-E , and TP 1-Containing Recruitment Domain , Leucine-Rich Repeat , Multiple Roles of CLAN ( Caspase-Associated (2004) (2)
The Chopawamsic Formation, a New Stratigraphic Unit in the Piedmont of Northeastern Virginia (2017) (2)
Announcement Effects on Bank Stock Prices: Citicorp's Increase in Loan Loss Reserves For Third World Debt (1989) (2)
Modulates Innate Immune Responses Ubiquitination and a B k Suppresses I B, k Inhibits NF- Salmonella typhimurium of Secreted Factor L Deubiquitinase Salmonella (2008) (2)
Interleukins and inhibitors in human lymphocyte regulation. (1984) (2)
Apoptosis of Breast Cancer Cells Related Apoptosis-Inducing Ligand to Induce − Factor Synthetic Triterpenoids Cooperate with Tumor Necrosis (2005) (2)
Orphan Nuclear Receptor TR3 (Nur77) Binds and Converts the Phenotype of Bcl-B, an Anti-Apoptotic Bcl-2-Family Protein Predominantly Expressed in Human Plasma Cells. (2006) (2)
STEM for Public Safety in Cyber: Training for Local Law Enforcement and Cyber Security (2019) (2)
Pro-Apoptotic Effects on CLL (Chronic Lymphocytic Leukemia) of ABT-737, a Novel Fully Synthetic Bcl-2/Bcl-XL Antagonist. (2004) (2)
The a 5 ( 81 integrin supports survival of cells on fibronectin and upregulates Bcl-2 expression (2005) (2)
Organo-selenium containing dental sealant inhibits biofilm formation by oral bacteria. (2022) (2)
Targeting Apoptosis via Chemical Design (2008) (2)
A new polymorphic probe on chromosome 6q: p327A (D6S93). (1991) (2)
Oncogenes in normal and neoplastic lymphocytes (1987) (2)
Regulation of expression of the bcl-2 gene. (1994) (1)
1-induced apoptosis of myeloid leukemia cells. modulate transforming growth factor beta the proto-oncogenes myb, myc, and bcl-2 The novel primary response gene MyD118 and (2013) (1)
BAFF Support Survival of Chronic Lymphocytic Leukemia B Cells by a Pathway Independent of Stromal Derived Factor-1α. (2004) (1)
Critical Molecular Studies to Strategically Plan Therapy in Chronic Lymphocytic Leukemia (CLL): Correlating Cellular Proteins with Defined Prognostic Patient Subsets and Their Response to Treatment. (2004) (1)
Integrins ( alpha 7 beta 1 ) in muscle function and survival . Disrupted expression in merosin-deficient congenital muscular dystrophy (2018) (1)
Expression of p 21 Protein Predicts Clinical Outcome in DLBCL Patients Older than 60 Years Treated with R-CHOP but not CHOP : A Prospective ECOG and Southwest Oncology Group Correlative Study on E 4494 (2010) (1)
ANGIOTENSIN II (ANG II) PROMOTES GROWTH AND INHIBITS APOPTOSIS IN THE NEONATAL RAT KIDNEY WITH UNILATERAL URETERAL OBSTRUCTION (UUO). • 2217 (1996) (1)
Binding Properties of the C‐terminal Domain of VIAF (2008) (1)
Protooncogene Expression in Lymphoid Cells Implications for the Regulation of Normal Cellular Growth (1987) (1)
Bcl‐x and Bcl‐2 immunoreactivity in postnatal mouse barrel fields (1998) (1)
POSSIBLE ANTIOXIDANT ACTION OF THE Bcl-2 PROTEIN (1996) (1)
Methylation of the Tumor Suppressor Gene PTPRO (Receptor-Type Protein Tyrosine Phosphatase) Is Associated with Expression of Important Apoptosis-Related Proteins in Chronic Lymphocytic Leukemia (CLL). (2004) (1)
Rational Design and Real Time , In-Cell Detection of the Proapoptotic Activity of a Novel Compound Targeting Bcl-XL trials (2004) (1)
Expression of Concern: Cyclin B1/Cdk1 Phosphorylation of Mitochondrial p53 Induces Anti-Apoptotic Response (2019) (1)
Absence of Expression of c-sis and Transforming Growth Factor-β mRNA in Malignant Fibrous Histiocytoma (1993) (1)
A strategy for constructing inducible expression plasmids for T-lymphocytes. (1993) (1)
Disrupted Expression in Merosin-deficient Congenital Muscular Dystrophy (1997) (1)
Receptors Tumor Cells to Tumor Necrosis Factor-Family Death Identification of Small Molecules that Sensitize Resistant (2006) (1)
Regulation of c-myc mRNA levels in normal lymphocytes by modulators of cell proliferation (1985) (1)
Bcl-2, apoptosis and mitochondrial function (1993) (1)
Protein interaction cloning by far-Western screening of lambda-phage cDNA expression libraries. (1997) (1)
Legionnaires' disease. (1978) (1)
Inhibition of XIAP Enhances Specific Cytotoxic T Lymphocyte (CTL) Killing and CD20-Directed Antibody-Dependent Cellular Cytotoxicity of Chronic Lymphocytic Leukemia B Cells. (2004) (1)
Prostate Cancer Metastasis Precursor Cells Contributes to Anoikis Resistance of Circulating Human Increased Expression of Apoptosis Inhibitor Protein XIAP (2005) (1)
Caspase-8-activated signal predominates in keratinocyte anoikis (2002) (1)
Corrigendum to "Nod 1, a CARD protein, enhances pro-interleukin-1 beta processing through the interaction with pro-caspase-1" [Biochem. Biophys. Res. Commun. 299(4) (2002) 652-8]. (2021) (1)
Protooncogene Expression in Lymphoid Cells (1987) (1)
POP3 is a novel inhibitor of ALR inflammasomes and controls host defense to DNA virus infections (INM6P.411) (2014) (1)
Photogeologic map of the Elk Ridge-11 quadrangle, San Juan County, Utah (1955) (1)
Early Proterozoic volcanogenic sequences in central Colorado (1991) (1)
Abstract LB-74: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling (2014) (1)
Select high risk genetic features predict earlier progression following chemotherapy in chronic lymphocytic leukemia: Prospective randomized trial (Intergroup E2997) to evaluate justification for risk-adapted therapy. (2006) (1)
PTK7 Is Involved in the Chemotherapy Resistance of T-Cell Acute Lymphoblastic Leukemia through Interaction with FADD-Death Domain (2015) (1)
APOPTOSIS-RELATED GENE PRODUCTS IN BRAINS OF PEDIATRIC PATIENTS WITH HIV-1 ENCEPHALITIS (1996) (1)
Abstract 605: Apogossypolone derivative -BI97D6 effectively targets MCL1 overexpressing Acute Myeloid Leukemia cells. (2013) (0)
Strong immunostaining of lymphoid cells with an anti bcl 2 antiserum 9718 is a reliable marker of bcl 2 overexpression due to t14 18 (1992) (0)
Gene Transfer Investigations of Oncogenes Activated by Chromosomal Translocations in Human Lymphomas and Leukemias: BCL2 and C-MYC (1991) (0)
The Provincetown Plays: Second Series (2010) (0)
Air Refueling Director Lights Trainer: Analysis and Evaluation of Training Effectiveness. (1979) (0)
Molecular Cloning and Function of FAS/APO1 Associated Protein in Breast Cancer. (1996) (0)
Regulation of apoptosis in AMI, MDS and normal hematopoiesis (1996) (0)
Peter C. Nowell (1928–2016) (2017) (0)
BRCA1 mutant breast cancer cells are hypersensitive to DNA damaging agents resulting in elevated levels of apoptosis but are resistant to microtubule inhibitors (2000) (0)
Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection (2020) (0)
Expression , a Proapoptotic Member of the Bcl-2 Protein Family Bak Patterns of in Vivo Immunohistochemical Analysis of Updated (2006) (0)
Expression of BAX in Plasma Cell Dyscrasias 1 (2000) (0)
Mutations Found in Gastrointestinal Cancers Impairment of the Proapoptotic Activity of Bax by Missense Updated (2000) (0)
Guest Editor (2003) (0)
Corrections: Interactions Among Members of the Bcl-2 Protein Family Analyzed with a Yeast Two-Hybrid System (1995) (0)
Caspase 9 Translocation from Cytosol to Nuclei of Neurons Undergoing Apoptosis Following Human Traumatic Brain Injury (1999) (0)
Structure- and NMR-based design of novel Bcl-xL antagonists. (2008) (0)
Abstract 4318: Development of a novel SurrobodyTM that simultaneously activates both death receptors DR4 and DR5 and induces cancer cell death with high potency. (2013) (0)
Caspase-Activating Protein Nalp1 Is Directly Suppressed by Bcl-2 and Bcl-Xl. (2006) (0)
Expression of bcl-2 and the Progression of Human and Rodent Prostatic Cancers 1 (2008) (0)
An in vitro Study of Betadine’s Ability to Eliminate Live Bacteria on the Eye: Should It Be Used for Protection against Endophthalmitis? (2022) (0)
Caspase Activation Pathways: an Overview (2003) (0)
Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6. (2009) (0)
Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis. (2004) (0)
Lymphoma in Mice Lymphocytic Leukemia / Small Lymphocytic Lymphocytes Predisposes to Chronic TNFR-Associated Factor 2 Deficiency in B Pindado (2012) (0)
Derives catecholiques destines au traitement du cancer (2004) (0)
Erratum: Community crystal gazing (2016) (0)
Advances in Brief Role of bcl-2 in Growth Factor Triggered Signal Transduction 1 (2006) (0)
Protein tyrosine kinase p56-Lck regulates lymphocyte function- associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell [published erratum appears in J Exp Med 1995 Jan 1;181(1):442] (1994) (0)
Colorectal Adenocarcinomas Elevated Expression of Bcl-X and Reduced Bak in Primary Updated Version (2006) (0)
Comparison of small remotely operated vehicles and diver-operated video of circalittoral benthos (2015) (0)
The antiapoptotic bcl-2 proteins are highest and caspases are not activated in basal keratinocytes expressing high levels of p63 (2001) (0)
Reminiscences of Ben Hill (1906) (0)
STRUCTURE-FUNCTION INVESTIGATIONS OF Bcl-2 FAMILY PROTEINS (1996) (0)
R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL. (2005) (0)
Mechanisms of Apoptosis Regulation: Relevance to Heart Disease (1998) (0)
retinamide and effect of deregulated bcl-2 Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) (2011) (0)
Guest Editor (2008) (0)
Prognostic Signiﬁcance of Bax Protein Expression in Diffuse Aggressive Non-Hodgkin’s Lymphoma (1997) (0)
Abstract 4609: Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of c-FLIP and sensitization of cancer cells to TRAIL. (2013) (0)
Development and validation of an RNAi screen for ABT-737 sensitizers (2010) (0)
RIP2beta: Identifikation und Charakterisierung einer neuen alternativen Spleißvariante der Receptor Interacting Protein Kinase RIP2 (2010) (0)
Arctic Research. (1962) (0)
Conference Abstracts (2001) (0)
Regulator of Centrosome Dynamics and Cytokinesis HBXIP , Cellular Target of Hepatitis B Virus Oncoprotein , Is a (2006) (0)
Procedes utilisant l'expression du bag comme agent de differentiation cellulaire, et comme marqueur (2003) (0)
Photogeologic Map, Elk Ridge-11 Quadrangle, San Juan County, Utah (1955) (0)
Metabolic Syndrome and SIRT1 Mutation Impair Ca2+ Channels in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine (2021) (0)
FIBROMYXOMA OF THE MANDIBLE (1950) (0)
Advances in Brief Apoptosis Induction by the Photosensitizer Verteporfin : Identification of Mitochondrial Adenine Nucleotide Translocator as a Critical Target 1 (2001) (0)
Cellular FLIP Inhibits (cid:2) -Catenin Ubiquitylation and Enhances Wnt Signaling (2004) (0)
NLRs: Sentinels of innate immunity or cancer culprits? (2014) (0)
DATELINE Edinburgh (1997) (0)
Human Breast Cancer Cells Proto-Oncogene Expression in Bcl-2 Mechanism Involving Estrogen Promotes Chemotherapeutic Drug Resistance by a Updated (2006) (0)
Short Communication Immunohistochemical Analysis of Mci-1 and Bcl-2 Proteins in Normal and Neoplastic Lymph Nodes (2007) (0)
Photogeologic map of the Straight Cliffs-9 quadrangle, Kane County, Utah (1955) (0)
Absence of t(14;18) Major and Minor Breakpoints and of BcI-2 Protein (2007) (0)
The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2. (2004) (0)
Scalable proportional active state-of-balance compensation method for managing variations in the age of batteries (2012) (0)
Acupuncture (2020) (0)
Chemical Biology and Biomedical Application of Synthetic Molecules Targeted to Apoptosis Regulated by the Bcl-2 Family (2006) (0)
Functions of Beta- and Gamma-Catenins in Prostate Cancer (1999) (0)
Gene expression profiling of glioblastoma cell lines using cDNA microarrays: Association with response to chemotherapeutic drugs (2004) (0)
20 Apoptosis as a Goal of Cancer Gene Therapy (1999) (0)
Corrigendum: Yeretssian et al. reply (2012) (0)
Red Russia: The Triumph of the Bolsheviki (2017) (0)
Fittings Design for Home Lighting: A British Approach (1964) (0)
The efficacy of organo-selenium conjugated cellulose polymer dressing to inhibit Candida albicans biofilm formation. (2022) (0)
Hodgkin's disease High expression of the bcl-x gene in Reed-Sternberg cells of (2011) (0)
Clerks At The Table (2013) (0)
induction of Mcl-1 Protection of CLL B cells by a follicular dendritic cell line is dependent on (2013) (0)
Apoptosis Caused by Caspases (2003) (0)
Lymphocytic Leukemia/Small Lymphocytic Lymphocytes Predisposes to Chronic TNFR-Associated Factor 2 Deficiency in B (2014) (0)
Involvement of both intrinsic and extrinsic cell death pathways by 8-amino-adenosine in multiple myeloma (2005) (0)
Leukemic Relapse Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of (2013) (0)
AML Progenitor/Stem Cells Overexpress XIAP and Are Sensitive to the Small Molecular XIAP Inhibitor 1396-11. (2006) (0)
Third Reading Print (2013) (0)
PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor (cid:2) B Activation Pathways (2002) (0)
Integrins ( a 7 b 1 ) in Muscle Function and Survival Disrupted Expression in Merosin-deficient Congenital Muscular Dystrophy (2013) (0)
GM1 Administration Prevents Alterations in BCL‐2 and Bax Expression in Substantia Nigra Neurons Following MPTP Administration a (1998) (0)
Signal Transduction and Apoptosis Dysregulation in Cancer (2003) (0)
In vitro and in vivo efficacy and toxicity comparison between ApoGossypol and Gossypol, Bcl-2 antagonists (2008) (0)
Mice lacking bi-1 gene demonstrate accelerated liver regeneration (2006) (0)
Photogeologic map, Straight Cliffs 9 quadrangle, Kane County, Utah (1954) (0)
100 and 50 years ago (1999) (0)
Apoptosis and Bcl-2 homologs in developing human gut 891 (2000) (0)
Unrecognized early contributors to the science of radiology from the University of Kentucky. (1996) (0)
Design, synthesis and evaluation of novel Apogossypol derivatives targeting anti-apoptotic Bcl-2 family proteins (2008) (0)
Molecular and Cellular Pathobiology PCTAIRE 1 Phosphorylates p 27 and Regulates Mitosis in Cancer Cells (2014) (0)
Possible Involvement of Bax Inhibitor 1 (BI-1), A Modulator for Endoplasmic Reticulum (ER) Cellular Stress, in Affective Resilience (2010) (0)
TARGETING TNF-RECEPTOR ASSOCIATED FACTORS ( TRAFs ) FOR THERAPEUTIC INTERVENTION (2014) (0)
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cells . promoting apoptosis in human breast cancer growth-inhibitory effect of retinoic acid by Retinoic acid receptor beta mediates the (1996) (0)
Oil development and conservation in Arctic America (1972) (0)
Map of the lower portion of the Teton Glacier, Grand Teton National Park, Wyoming (1964) (0)
Abstract 2008: Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells (2012) (0)
Erratum: Establishing apoptosis resistant cell lines for improving protein productivity of cell culture (2004) (0)
In Search of Novel Cancer Therapeutics: Assessing the NCI Natural Product Library against Ten Anti-Apoptotic Protein Targets (2013) (0)
SIRT1 Mutation Impairs Ca2+ Buffering in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine (2022) (0)
Collaborative QSAR analysis of Ames mutagenicity (2011) (0)
Abstract LB-128: High throughput screening kinase activators of Atg4B for cancer therapy. (2013) (0)
Biophysical Mechanism of Converting Apoptosis Regulator Bcl-2 from a Protector to a Killer in Cancer Cells By A Short Nur77-derived Peptide (2009) (0)
Protein Domains Involved in Apoptosis Regulation (2003) (0)
Analogues de l'apogossypol pour leur utilisation dans le traitement du cancer (2004) (0)
REGULATION DE L'EXPRESSION DU GENE bcl-2 (1994) (0)
Metabolic Syndrome and SIRT1 Mutation Impair Ca2+Channels in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine (2022) (0)
Chemical Biology Strategy Reveals Cell Lineage- and Cell Differentiation-Specific Small Molecule Inhibitors of NF-κB. (2012) (0)
Regulation of Androgen Responses in Prostate Cancer by BAG-1 (1999) (0)
Steroid-3-o-sulfamate derivatives as estrone sulfatase inhibitors (1998) (0)
Interstitial Cells of Cajal: Pacemaker Cells? (1999) (0)
Receptor-Associated Factor 3: Implications of the BAFF Receptor by TNF Key Molecular Contacts Promote Recognition (2004) (0)
treatment of leukemia and multiple myeloma The ubiquitin-activating enzyme E1 as a therapeutic target for the (2013) (0)
A Comparison of Small Study Groups and Traditional Classes on Acquaintance Volume, Reported Problems, and Academic Achievement (1971) (0)
The Recent Primary Election in Georgia (1907) (0)
XWH-081-0209 TITLE : A Mechanistic Study of Proapoptotic Daxx-Par 4 Axis in Prostate Cancer (2011) (0)
Tales of Woe (2010) (0)
Sparsely labeled coral images segmentation with Latent Dirichlet Allocation (2020) (0)
Human enterocytic apoptosis and survival: Differentiation state-specific control mechanisms (2001) (0)
Differential expression and regulation of Bcl-2 homologs as a function of human enterocytic differentiation (2000) (0)
Abstract 61: A new serotype chimera Cancer Terminator Virus (Ad.5/3-CTV) expands the efficiency and specificity of prostate cancer gene transfer and therapy (2012) (0)
Effects of p 561 ck Deficiency on the Growth and Cytolytic Effector Function of an Interleukin-2-Dependent Cytotoxic T-Cell Line (0)
Abstract 2928: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress. (2013) (0)
Regulation of proto-oncogene expression during T lymphocyte activation and proliferation. (1987) (0)
In Vitro Reconstitution of the NALP1 Inflammasome Reveals Requirements for Caspase Activation. (2006) (0)
Triterpenoids Display Single Agent Activity in a Mouse Model of CLL/SBL. (2006) (0)
07.16 Nlrp1 mutations cause autoinflammatory diseases in human: implication of the nlrp1 inflammasome? (2017) (0)
Photogeologic map, White Canyon-1 quadrangle, San Juan and Garfield Counties, Utah (1955) (0)
1 Caspase-3 is Essential for Procaspase-9 Processing and Cisplatin-Induced Apoptosis of MCF-7 Breast Cancer Cells 1 (1999) (0)
Dosages selectifs pour identifier des agents qui modifient l'expression de genes dependante de la proteine p53 (1995) (0)
A multivariate analysis of tumour biologic factor predicting response to cytotoxic treatment in advanced breast cancer (1997) (0)
Proteines associees a la bcl-2 (1994) (0)
Infection Chlamydia Caspase-Independent Apoptosis during Role of Bcl-2 Family Members in (2001) (0)
Preliminary geologic map of the Bergen Park area, Jefferson and Clear Creek Counties, Colorado (1971) (0)
Novel Phosphorylation and Ubiquitination Sites Regulate ROS-Dependent Degradation of Anti-Apoptotic c-FLIP Protein. (2013) (0)
4th IUBMB conference on 'The Life and Death of the Cell'. Edinburgh 14-17th July 1996. (1997) (0)
Guest Editor (2008) (0)
Roadblocks to caspase-dependent cell death in cancer: Therapeutic strategies. (2006) (0)
MalignanciesExpression in Normal Tissues and Lymphoid TNFR-Associated Factor Family Protein (2000) (0)
prognostic markers in acute leukemia Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential (2013) (0)
Analysis and validation of differential gene expression in serous ovarian tumors of varying grade and malignant potential (2005) (0)
P679 X-linked inhibitor of apoptosis protein in early-onset inflammatory bowel disease (2013) (0)
BARC: A Novel Apoptosis Regulator (2005) (0)
Cancer and Cell Death (2017) (0)
Strategy for in vitro and ex-vivo testing of neutrophins signaling pathways based on immunoproteomic array profiling (2006) (0)
Dual Agonist Surrobody Simultaneously Activates Death Receptors DR 4 and DR 5 to Induce Cancer Cell (2015) (0)
Geologic map of the Mount McKinley quadrangle, Alaska (1954) (0)
Sa1767 X-Linked Inhibitor of Apoptosis Protein in Early-Onset Inflammatory Bowel Disease (2013) (0)
p75 neurotrophin receptor co-localizes with sortilin and induces apoptosis in a subpopulation of human keratinocytes (2005) (0)
Controllers of apoptosis in herniated and diseased intervertebral disc (2004) (0)
Aggressive tax avoidance for real estate investors : how to maka sure you aren't paying one more cent in taxes than the law requires (1987) (0)
American law studies : or, Self-preparation for practice in the United States : A course of instruction, reading, and exercises for students and young lawyers, by which they can thoroughly and rapidly train themselves for legal business (0)
Photogeologic map, Elk Ridge-6 quadrangle, San Juan County, Utah (1954) (0)
Alteration of CD3 and CD28 activation pathways in CD2-jurkat cell variants (1988) (0)
Abstract 217: BCR-ABL tyrosine kinase inhibition combined with a novel pan BCL2 family inhibitor abrogates leukemia stem cell survival in a niche-dependent manner. (2013) (0)
802 Overcoming Imatinib Resistance by Targeting XIAP and ARC (Apoptosis Repressor with Caspase Recruitment Domain) in Blast Crisis CML Cells (2011) (0)
Labor's grand old man (1976) (0)
Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells. (2010) (0)
Recombinant Interleukin 2Regulates Levels ofc-myc mRNA ina ClonedMurineT Lymphocyte (1985) (0)

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