Jay D. Gralla
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Biology
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Microbiology
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Biology
Jay D. Gralla's Degrees
- PhD Molecular Biology Stanford University
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)Jay D. Gralla's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Control site location and transcriptional regulation in Escherichia coli. (1991) (509)
- The Bacterial Enhancer-Dependent ς54(ςN) Transcription Factor (2000) (451)
- Changes in the linking number of supercoiled DNA accompany growth transitions in Escherichia coli (1987) (281)
- Free energy of imperfect nucleic acid helices. II. Small hairpin loops. (1973) (262)
- KMnO4 as a probe for lac promoter DNA melting and mechanism in vivo. (1989) (248)
- Cycling of ribonucleic acid polymerase to produce oligonucleotides during initiation in vitro at the lac UV5 promoter. (1980) (241)
- Free energy of imperfect nucleic acid helices. 3. Small internal loops resulting from mismatches. (1973) (221)
- DNA supercoiling promotes formation of a bent repression loop in lac DNA. (1987) (219)
- Polymerase II promoter activation: closed complex formation and ATP-driven start site opening. (1992) (212)
- Probing the Escherichia coli glnALG upstream activation mechanism in vivo. (1988) (212)
- Interaction of RNA polymerase with lacUV5 promoter DNA during mRNA initiation and elongation. Footprinting, methylation, and rifampicin-sensitivity changes accompanying transcription initiation. (1985) (158)
- The acidic activator GAL4-AH can stimulate polymerase II transcription by promoting assembly of a closed complex requiring TFIID and TFIIA. (1992) (149)
- Osmotic Stress. (2009) (130)
- DNA dynamic flexibility and protein recognition: Differential stimulation by bacterial histone-like protein HU (1988) (122)
- Escherichia coli promoter opening and −10 recognition: mutational analysis of σ70 (2000) (116)
- Converting Escherichia coli RNA Polymerase into an Enhancer-Responsive Enzyme: Role of an NH2-Terminal Leucine Patch in σ54 (1995) (106)
- Footprinting protein-DNA complexes in vivo. (1991) (105)
- Spacer mutations in the lac ps promoter. (1982) (104)
- All three elements of the lac ps promoter mediate its transcriptional response to DNA supercoiling. (1987) (100)
- Promoter opening via a DNA fork junction binding activity. (1998) (96)
- Osmo-regulation of bacterial transcription via poised RNA polymerase. (2004) (94)
- Sigma38 (rpoS) RNA Polymerase Promoter Engagement via −10 Region Nucleotides* 210 (2001) (93)
- Potassium glutamate as a transcriptional inhibitor during bacterial osmoregulation (2006) (90)
- Rapid "footprinting" on supercoiled DNA. (1985) (87)
- Transcriptional control—Lessons from an E. coli promoter data base (1991) (86)
- Stalling of Escherichia coli RNA polymerase in the +6 to +12 region in vivo is associated with tight binding to consensus promoter elements. (1994) (86)
- TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape (2005) (83)
- Escherichia coli ribosomal RNA transcription: regulatory roles for ppGpp, NTPs, architectural proteins and a polymerase‐binding protein (2004) (81)
- DNA sequence directs placement of histone cores on restriction fragments during nucleosome formation. (1979) (78)
- Transcription reinitiation rate: a special role for the TATA box (1997) (75)
- Biological sciences: mRNA is expected to form stable secondary structures (1974) (74)
- Supercoiling response of the lac ps promoter in vitro. (1985) (73)
- Direct physical evidence for secondary structure in an isolated fragment of R17 bacteriophage mRNA (1974) (71)
- Promoter opening by sigma(54) and sigma(70) RNA polymerases: sigma factor-directed alterations in the mechanism and tightness of control. (2000) (70)
- Multiple pathways to bypass the enhancer requirement of sigma 54 RNA polymerase: roles for DNA and protein determinants. (1997) (69)
- Interrelated effects of DNA supercoiling, ppGpp, and low salt on melting within the Escherichia coli ribosomal RNA rrnB P1 promoter (1992) (68)
- 5' nucleotide heterogeneity and altered initiation of transcription at mutant lac promoters. (1982) (66)
- Activation and repression of E. coli promoters. (1996) (65)
- Context-dependent effects of upstream A-tracts. Stimulation or inhibition of Escherichia coli promoter function. (1994) (63)
- The domain structure of sigma 54 as determined by analysis of a set of deletion mutants. (1994) (63)
- Productive and abortive initiation of transcription in vitro at the lac UV5 promoter. (1980) (63)
- Formation of blocking lesions at identical DNA sequences by the nitrosourea and platinum classes of anticancer drugs. (1987) (61)
- Multiple In Vivo Roles for the −12-Region Elements of Sigma 54 Promoters (1998) (59)
- A fork junction DNA–protein switch that controls promoter melting by the bacterial enhancer‐dependent sigma factor (1999) (59)
- A three-step pathway of transcription initiation leading to promoter clearance at an activation RNA polymerase II promoter (1996) (58)
- Bacterial gene regulation from distant DNA sites (1989) (57)
- Function of the bacterial TATAAT −10 element as single-stranded DNA during RNA polymerase isomerization (2001) (53)
- High-resolution analysis of lac transcription complexes inside cells. (1986) (48)
- Uncoupling of initiation and reinitiation rates during HeLa RNA polymerase II transcription in vitro (1993) (47)
- Probing co-operative DNA-binding in vivo. The lac O1:O3 interaction. (1988) (46)
- In situ nucleoprotein structure at the SV40 major late promoter: melted and wrapped DNA flank the start site. (1989) (45)
- DNA melting within stable closed complexes at the Escherichia coli rrnB P1 promoter. (1992) (44)
- Lactose Operator Sequences and the Action of Lac Repressor (1975) (43)
- Dual mechanism of repression at a distance in the lac operon. (1988) (43)
- Identification of an N-Terminal Region of Sigma 54 Required for Enhancer Responsiveness (1998) (43)
- Lac UV5 transcription in vitro. Rate limitation subsequent to formation of an RNA polymerase-DNA complex. (1979) (41)
- PCR mutagenesis identifies a polymerase-binding sequence of sigma 54 that includes a sigma 70 homology region (1995) (40)
- Thermodynamic and kinetic properties of short RNA helices: the oligomer sequence AnGCUn. (1974) (40)
- Functional roles for the glutamines within the glutamine-rich region of the transcription factor sigma 54. (1994) (39)
- Nucleotide Requirements for Activated RNA Polymerase II Open Complex Formation in Vitro(*) (1995) (39)
- Differential ability of proximal and remote element pairs to cooperate in activating RNA polymerase II transcription (1991) (39)
- Transcription reinitiation rate: a potential role for TATA box stabilization of the TFIID:TFIIA:DNA complex. (1999) (38)
- Analysis of the N-terminal leucine heptad and hexad repeats of sigma 54. (1994) (37)
- Escherichia coli promoter opening and -10 recognition: mutational analysis of sigma70. (2000) (37)
- The Transcription Initiation Pathway of Sigma 54 Mutants That Bypass the Enhancer Protein Requirement (1996) (35)
- MINIREVIEW The Bacterial Enhancer-Dependent s 54 ( s N ) Transcription Factor (2000) (34)
- [4] Promoter recognition and mRNA initiation by Escherichia coli Eσ70 (1990) (34)
- TATA-flanking Sequences Influence the Rate and Stability of TATA-binding Protein and TFIIB Binding* (2001) (34)
- Osmolyte‐induced transcription: −35 region elements and recognition by sigma38 (rpoS) (2006) (34)
- Genomic position analyses and the transcription machinery. (1998) (34)
- Multiple ATP‐dependent steps in RNA polymerase II promoter melting and initiation (1997) (33)
- Properties of initiator-associated transcription mediated by GAL4-VP16 (1993) (33)
- RNA polymerase binding using a strongly acidic hydrophobic-repeat region of sigma 54. (1994) (33)
- A novel bacterial transcription cycle involving sigma 54. (1995) (32)
- DNA-binding determinants of sigma 54 as deduced from libraries of mutations (1997) (32)
- Mutation-induced changes in RNA polymerase-lac ps promoter interactions. (1982) (32)
- Kinetic investigation of the mechanism of RNA polymerase binding to mutant lac promoters. (1980) (31)
- Regulation of Sigma 54-Dependent Transcription by Core Promoter Sequences: Role of −12 Region Nucleotides (1999) (30)
- Roles for Non-TATA Core Promoter Sequences in Transcription and Factor Binding (2000) (30)
- A role for the acidic trimer repeat region of transcription factor sigma 54 in setting the rate and temperature dependence of promoter melting in vivo. (1992) (29)
- A common ATP requirement for open complex formation and transcription at promoters containing initiator or TATA elements. (1993) (29)
- Isolation and properties of enhancer‐bypass mutants of sigma 54 (1997) (27)
- Entry of RNA polymerase at the lac promoter (1985) (26)
- Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes. (1994) (26)
- Activation of the lac promoter and its variants. Synergistic effects of catabolite activator protein and supercoiling in vitro. (1989) (26)
- Melting during steady-state transcription of the rrnB P1 promoter in vivo and in vitro (1992) (25)
- Specific binding and protection of form II SV40 deoxyribonucleic acid by ribonucleic acid polymerase II from wheat germ. (1980) (25)
- Alterations in two conserved regions of promoter sequence lead to altered rates of polymerase binding and levels of gene expression. (1980) (24)
- Abortive Cycling and the Release of Polymerase for Elongation at the σ54-dependent glnAp2 Promoter (*) (1995) (24)
- In vitro transcription and start site selection in Schizosaccharomyces pombe. (2002) (24)
- Control of the Timing of Promoter Escape and RNA Catalysis by the Transcription Factor IIB Fingertip* (2008) (23)
- Abortive Initiation and First Bond Formation at an Activated Adenovirus E4 Promoter (*) (1995) (23)
- Roles for the C-terminal Region of Sigma 54 in Transcriptional Silencing and DNA Binding* (2001) (23)
- Regulation of transcription by acetate in Escherichia coli: in vivo and in vitro comparisons (2008) (21)
- lac Operator nucleosomes. 1. Repressor binds specifically to operator within the nucleosome core. (1980) (21)
- Competition for formation of nucleosomes on fragmented SV40 DNA: a hyperstable nucleosome forms on the termination region. (1987) (21)
- General stress response signalling: unwrapping transcription complexes by DNA relaxation via the sigma38 C‐terminal domain (2008) (21)
- In situ nucleoprotein structure involving origin-proximal SV40 DNA control elements. (1990) (20)
- New Roles for Conserved Regions within a ς54-dependent Enhancer-binding Protein* (2002) (19)
- Promoter Use by ς38 (rpoS) RNA Polymerase (2002) (19)
- A critical role for chromatin in mounting a synergistic transcriptional response to GAL4-VP16 (1994) (19)
- Remodeling and activation of Escherichia coli RNA polymerase by osmolytes. (2008) (18)
- lac Operator nucleosomes. 2. lac Nucleosomes can change conformation to strengthen binding by lac repressor. (1980) (18)
- Mechanism of Stimulation of Ribosomal Promoters by Binding of the +1 and +2 Nucleotides* (2004) (18)
- Specific termination of in vitro transcription by calf thymus RNA polymerase III (1984) (18)
- Roles for Inhibitory Interactions in the Use of the–10 Promoter Element by σ70 Holoenzyme* (2003) (17)
- Ki-B5: a monoclonal antibody unrelated to CD45 recognizes normal and neoplastic human B cells in routine paraffin sections (1991) (17)
- The replication activation potential of selected RNA polymerase II promoter elements at the simian virus 40 origin (1992) (17)
- Poising of Escherichia coli RNA polymerase and its release from the sigma 38 C-terminal tail for osmY transcription. (2008) (15)
- Stimulation of the XPB ATP-dependent helicase by the beta subunit of TFIIE (2005) (15)
- Micrococcal nuclease as a probe for bound and distorted DNA in lac transcription and repression complexes. (1989) (15)
- Factor interactions at simian virus 40 GC-box promoter elements in intact nuclei (1987) (15)
- Ki-B5: a monoclonal antibody unrelated to CD45 recognizes normal and neoplastic human B cells in routine paraffin sections. (1991) (14)
- Effect of DNA bases and backbone on sigma70 holoenzyme binding and isomerization using fork junction probes. (2003) (14)
- Open complex formation in vitro by sigma38 (rpoS) RNA polymerase: roles for region 2 amino acids. (2003) (13)
- Signaling through sigma (2000) (12)
- Escherichia coli pfs Transcription: Regulation and Proposed Roles in Autoinducer-2 Synthesis and Purine Excretion (2006) (12)
- RNA polymerase II phosphorylation: uncoupling from GAL4-VP16 directed open complex formation and transcription in a reconstituted system. (1994) (11)
- Promoter use by sigma 38 (rpoS) RNA polymerase. Amino acid clusters for DNA binding and isomerization. (2002) (11)
- Cisplatin resistance and mechanism in a viral test system: SV40 isolates that resist inhibition by the antitumor drug have lost regulatory DNA. (1990) (11)
- Promoter recognition and mRNA initiation by Escherichia coli E sigma 70. (1990) (10)
- Global steps during initiation by RNA polymerase II. (1996) (10)
- DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus. (2014) (10)
- Differential effects of cisplatin on the expression of chimeric marker genes in CV-1 cells. (1992) (10)
- The Schizosaccharomyces pombe open promoter bubble: mammalian-like arrangement and properties. (2004) (9)
- Promoter Activation via a Cyclic AMP Response Element in Vitro * (1997) (9)
- Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells. (1992) (9)
- Nucleotide-dependent isomerization of Escherichia coli RNA polymerase. (2004) (9)
- In vivo expression of lac promoter variants with altered -10, -35, and spacer sequences. (1983) (9)
- The Use of ATP and Initiating Nucleotides during Postrecruitment Steps at the Activated Adenovirus E4 Promoter* (1999) (9)
- Cycling of Ribonucleic Acid Polymerase To Produce Oligonucleotides during Initiation in Vitro at the lac UV 5 (2011) (8)
- Transcription activation by GC-boxes: evaluation of kinetic and equilibrium contributions. (1996) (7)
- Simian virus 40 associates with nuclear superstructures at early times of infection (1987) (7)
- Roles for inhibitory interactions in the use of the -10 promoter element by sigma 70 holoenzyme. (2003) (6)
- The TFIIB Tip Domain Couples Transcription Initiation to Events Involved in RNA Processing* (2010) (5)
- The SV40 termination region exhibits an altered helical DNA conformation (1987) (5)
- The interaction of RNA polymerase II with non-promoter DNA sites. (1981) (5)
- RNA polymerase binding using a strongly acidic hydrophobic-repeat region of 54 ( ar factors / tanscrpton ) (4)
- Control site location and transcriptional regulation in Escherichia coli (1991) (4)
- 4 – Permanganate Probing (1993) (3)
- Programmed factor binding to simian virus 40 GC-box replication and transcription control sequences (1990) (2)
- Opening promoters for m-RNA transcription. (1993) (2)
- New roles for conserved regions within a sigma 54-dependent enhancer-binding protein. (2002) (1)
- Poising of E. coli RNA polymerase and its release from the σ 38 C-terminal tail for osmY transcription (2009) (0)
- DNA-protein interactions in transcription: Proceedings of Director's Sponsors-UCLA Symposium held at Keystone, Colorado, April 4-10, 1988 (1989) (0)
- Crystal Structure of NtrC4 DNA-binding domain bound to double-stranded DNA (2012) (0)
- Nucleic Acids Research Mkrococcal nuclea.se as a probe for bound and distorted DNA in lac transcription and repression complexes (2005) (0)
- Spacer mutations in the lac pS promoter ( transcription / RNA polymerase / recombinant promoter ) (2003) (0)
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