J. Dennis Mcgarry

J. Dennis Mcgarry's AcademicInfluence.com Rankings

J. Dennis Mcgarry

Biology

#7288

World Rank

#10184

Historical Rank

Molecular Biology

#828

World Rank

#849

Historical Rank

Biochemistry

#996

World Rank

#1109

Historical Rank

biology Degrees

Download Badge

Biology

J. Dennis Mcgarry's Degrees

PhD Biochemistry University of California, San Diego
Bachelors Chemistry University of California, San Diego

Why Is J. Dennis Mcgarry Influential?

(Suggest an Edit or Addition)

(See a Problem?)

J. Dennis Mcgarry's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. (1997) (1596)
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. (2002) (1453)
Regulation of hepatic fatty acid oxidation and ketone body production. (1980) (1261)
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. (1994) (795)
What if Minkowski had been ageusic? An alternative angle on diabetes. (1992) (665)
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. (1977) (628)
Metabolic coupling factors in pancreatic beta-cell signal transduction. (1995) (578)
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. (1999) (576)
Fatty acids, lipotoxicity and insulin secretion (1999) (573)
Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat. (1983) (538)
An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. (1976) (538)
Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. (1978) (504)
Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes (2001) (389)
Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. (1996) (377)
The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. (1997) (360)
Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. (1989) (318)
Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. (2001) (304)
The metabolic derangements and treatment of diabetic ketoacidosis. (1983) (283)
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. (1998) (273)
Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? (1983) (271)
Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. (2002) (265)
The glucose paradox. Is glucose a substrate for liver metabolism? (1984) (247)
Role of carnitine in hepatic ketogenesis. (1975) (235)
Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. (1998) (231)
Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon. (1975) (214)
The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. (1978) (211)
Increased Lipogenic Capacity of the Islets of Obese Rats: A Role in the Pathogenesis of NIDDM (1997) (193)
More Direct Evidence for a Malonyl-CoA–Carnitine Palmitoyltransferase I Interaction as a Key Event in Pancreatic β-Cell Signaling (1994) (193)
Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function. (1993) (187)
The effects of starvation and refeeding on carbohydrate and lipid metabolism in vivo and in the perfused rat liver. The relationship between fatty acid oxidation and esterification in the regulation of ketogenesis. (1973) (183)
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. (1987) (181)
Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay. (1978) (170)
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. (1999) (163)
Mitochondrial Carnitine Palmitoyltransferase I Isoform Switching in the Developing Rat Heart (*) (1995) (162)
Regulation of the activity of caspases by L‐carnitine and palmitoylcarnitine (2000) (160)
In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis. (1979) (160)
Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion (1998) (159)
Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. (1984) (155)
Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic β-Cell Line INS-1* (1997) (148)
A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion. (1998) (146)
Expression of a cDNA Isolated from Rat Brown Adipose Tissue and Heart Identifies the Product as the Muscle Isoform of Carnitine Palmitoyltransferase I (M-CPT I) (1996) (146)
The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. (2002) (146)
The regulation of ketogenesis from octanoic acid. The role of the tricarboxylic acid cycle and fatty acid synthesis. (1971) (142)
Glucose-fatty acid interactions in health and disease. (1998) (138)
From dietary glucose to liver glycogen: the full circle round. (1987) (138)
Ketone body metabolism in the ketosis of starvation and alloxan diabetes. (1970) (135)
The regulation of ketogenesis from oleic acid and the influence of antiketogenic agents. (1971) (135)
Maternal-fetal carnitine relationship and neonatal ketosis in the rat. (1976) (135)
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. II. Use of detergents and antibodies. (1987) (134)
Regulation of ketogenesis and clinical aspects of the ketotic state. (1972) (131)
Carnitine biosynthesis, metabolism, and functions (1980) (128)
Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene. (1995) (127)
Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme. (1994) (121)
Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes. (1996) (120)
Hormonal control of ketogenesis. (1979) (119)
Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme. (1994) (118)
Limitations of acetate as a substrate for measuring cholesterol synthesis in liver. (1974) (116)
Disordered metabolism in diabetes: Have we underemphasized the fat component? (1994) (115)
Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes. (1997) (111)
In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose. (1981) (105)
Hormonal control of ketogenesis. Biochemical considerations. (1977) (105)
Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme. (2001) (101)
Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues. Relationship between ligand binding and inhibition of carnitine palmitoyltransferase I. (1983) (100)
Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II. (1990) (98)
Overexpression of a Modified Human Malonyl-CoA Decarboxylase Blocks the Glucose-induced Increase in Malonyl-CoA Level but Has No Impact on Insulin Secretion in INS-1-derived (832/13) β-Cells* (2001) (98)
Inter-tissue and inter-species characteristics of the mitochondrial carnitine palmitoyltransferase enzyme system. (1990) (97)
Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. (2001) (90)
Evidence for Suppression of Hepatic Glucose-6-Phosphatase with Carbohydrate Feeding (1984) (88)
Ketogenesis and its regulation. (1976) (84)
Bulk magnetic susceptibility effects on the assessment of intra‐ and extramyocellular lipids in vivo (2002) (83)
Lilly Lecture 1978. New perspectives in the regulation of ketogenesis. (1979) (82)
Engineering of Glycerol-stimulated Insulin Secretion in Islet Beta Cells (1997) (81)
Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B). (1997) (78)
Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment. (1978) (77)
Active hepatic glycogen synthesis from gluconeogenic precursors despite high tissue levels of fructose 2,6-bisphosphate. (1986) (75)
The mitochondrial carnitine palmitoyltransferase system: its broadening role in fuel homoeostasis and new insights into its molecular features. (1995) (74)
The glucose paradox: new perspectives on hepatic carbohydrate metabolism (1986) (69)
The metabolism of (minus)-octanoylcarnitine in perfused livers from fed and fasted rats. Evidence for a possible regulatory role of carnitine acyltransferase in the control of ketogenesis. (1974) (65)
Cerebral energy metabolism in short-chain fatty acid-induced coma. (1970) (64)
Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes. (1985) (62)
Catalytically important domains of rat carnitine palmitoyltransferase II as determined by site-directed mutagenesis and chemical modification. Evidence for a critical histidine residue. (1994) (61)
Kinetics of carnitine‐dependent fatty acid oxidation (1982) (60)
Effects of pH on the interaction of substrates and malonyl-CoA with mitochondrial carnitine palmitoyltransferase I. (1984) (59)
New insights into the mitochondrial carnitine palmitoyltransferase enzyme system. (1991) (59)
Acute reversal of experimental diabetic ketoacidosis in the rat with (+)-decanoylcarnitine. (1973) (57)
The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis. (1986) (57)
Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues. (1998) (56)
Topological and functional analysis of the rat liver carnitine palmitoyltransferase 1 expressed in Saccharomyces cerevisiae (1998) (53)
Studies of the development of diabetic ketosis in the rat. (1972) (53)
Ketogenesis and cholesterol synthesis in normal and neoplastic tissues of the rat. (1969) (52)
Effects of Exogenous Fatty Acid Concentration on Glucagon-induced Changes in Hepatic Fatty Acid Metabolism (1980) (50)
Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide. (1994) (49)
Systemic carnitine deficiency. (1978) (49)
The N-terminal Domain of Rat Liver Carnitine Palmitoyltransferase 1 Mediates Import into the Outer Mitochondrial Membrane and Is Essential for Activity and Malonyl-CoA Sensitivity* (1998) (47)
Malonyl-CoA and carnitine palmitoyltransferase I: an expanding partnership. (1995) (44)
Characteristics of fatty acid oxidation in rat liver homogenates and the inhibitory effect of malonyl-CoA. (1978) (43)
Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between. (2001) (38)
Regulation of lipoprotein lipase in different rat tissues. (1988) (37)
Systemic carnitine deficiency. (1980) (37)
The regulation of ketogenesis. (1982) (37)
Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion. (2003) (37)
Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity. (2000) (36)
Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats. (1981) (36)
Inhibitors of mitochondrial carnitine palmitoyltransferase I limit the action of proteases on the enzyme. Isolation and partial amino acid analysis of a truncated form of the rat liver isozyme. (1993) (35)
Interaction of malonyl-CoA and 2-tetradecylglycidyl-CoA with mitochondrial carnitine palmitoyltransferase I. (1985) (32)
Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia. (1993) (32)
Independence of cholesterol and fatty acid biosynthesis from cyclic adenosine monophosphate concentration in the perfused rat liver. (1974) (30)
Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats. (1984) (29)
Ketogenesis in vitro. (1969) (28)
Studies with (+)—Octanoylcarnitine in Experimental Diabetic Ketoacidosis (1974) (27)
Use of proton spectroscopy for detection of homozygous fatty ZDF-drt rats before weaning. (1995) (27)
Glucagon and ketogenesis. (1976) (25)
Expression and possible role of muscle-type carnitine palmitoyltransferase I during sperm development in the rat. (1998) (25)
Elucidation of the Mechanism by Which (+)-Acylcarnitines Inhibit Mitochondrial Fatty Acid Transport* (2000) (22)
Appetite Control: Does leptin lighten the problem of obesity? (1995) (22)
Lipid Metabolism I: Utilization and Storage of Energy in Lipid Form (2002) (21)
Mitochondrial import and processing of rat liver carnitine palmitoyltransferase II defines the amino terminus of the mature protein. Possibility of differential modification of the rat and human isoforms. (1991) (19)
A direct pathway for the conversion of propionate into pyruvate in Moraxella lwoffi. (1968) (13)
Carnitine palmitoyltransferase--structure/function/regulatory relationships. (1990) (12)
Concentrations of carnitine in the seminal fluid of normospermic, vasectomized, and castrated dogs. (1987) (12)
Systemic carnitine deficiency. Report of a fatal case with multisystemic manifestations. (1978) (12)
Expression of precursor and mature carnitine palmitoyltransferase II in Escherichia coli and in vitro: differential behaviour of rat and human isoforms. (1993) (11)
[Gluco-lipotoxicity and gene expression in the pancreatic beta cell]. (1998) (10)
A direct pathway for the metabolism of propionate in cell extracts from Moraxella lwoffi. (1968) (9)
Clinical and Biochemical Heterogeneity in an Italian Family with CPT II Deficiency due to Ser 113 Leu Mutation (2005) (8)
Regulation of hepatic fatty acid oxidation in the rat during feeding and starvation. (1981) (7)
Insights into the topography of mitochondrial carnitine palmitoyltransferase gained from the use of proteases. (1992) (7)
[Fatty acids, insulin resistance and pancreatic beta cell function]. (1998) (6)
Clarification of the nucleotide sequence at the 5'-end of the cDNA for rat liver carnitine palmitoyltransferase II. (1993) (6)
Fatty acids and beta-cell function (1997) (6)
Characterization of mutations in six L-CPT-I deficient patients (2001) (5)
Malonyl-CoA and Satiety? Food for Thought (2000) (5)
Alteration of developing and adult rat muscle membranes by zuclomiphene and other hypocholesterolemic agents (1978) (4)
AcrD-Dependent Kanamycin-Induced Antibiotic Resistance of Escherichia coli K-12 is not Modulated by the acrAB Repressor , AcrR (2013) (3)
A comparative study of the reversibility of the reaction catalysed by bacterial lipoamide dehydrogenase. (1968) (3)
Malonyl-CoA inhibition of carnitine palmitoyltransferase I: response to Dr. Saggerson's Letter (1982) (2)
Endocrine and Metabolic Adaptation to Starvation (1983) (1)
Hepatic glucose-6-phosphate cycling has no bearing on recently used isotopic procedures to investigate the pathways of glycogen synthesis. (1990) (1)
Fatty acids and beta-cell function (1997) (0)
Inhibition of ketogenesis in vitro and in vivo by (+) decanoylcarnitine (1973) (0)
and human preadipocytes Fat depot origin affects fatty acid handling in cultured rat (2013) (0)
Is 2-bromopalmitate a valid tool to trace the tissue distribution of circulating fatty acids? (2000) (0)
Malonyl-CoA and Satiety? Food for ThoughtMcGarry COMMENT (2000) (0)
The M.I.P. concise Indonesian dictionary : English-Indonesian, Indonesian-English (1979) (0)
Travels with CPT I - from liver to germ cell with stops in between (2001) (0)
A NEW GENETIC RAT MODEL OF DIABETES MELLITUS (DM) FOR STUDIES OF LOWER URINARY TRACT (LUT) DYSFUCTION (1999) (0)
Pitfalls in interpretation of experiments using etomoxir as an inhibitor of CPT I-dependent fatty acid oxidation (2000) (0)
WEIGHT REGULATION AND THE ROLE OF LEPTIN (1999) (0)
Bright minds, limited tools (1990) (0)
Glucolipoxia and the etiology of obesity-associated Type 2 diabetes (2009) (0)
Studies with (plus)--octanoylcarnitine in experimental diabetic ketoacidosis. (1974) (0)
An overview of the central role of CPT I in the regulation of metabolism (2001) (0)
Pathway for the Metabolism of Propionate in Cell Extracts (2005) (0)
Re-evaluation of phenformin therapy in maturity-onset diabetic patients. (1979) (0)
Role of Fatty Acids in the Metabolic Complications of Diabetes (1990) (0)

This paper list is powered by the following services:

J. Dennis Mcgarry's Academic­Influence.com Rankings

J. Dennis Mcgarry's Degrees

Why Is J. Dennis Mcgarry Influential?

J. Dennis Mcgarry's Published Works

Published Works

J. Dennis Mcgarry's AcademicInfluence.com Rankings