Jean‐dominique Vassalli
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#11111
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Logic
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#6217
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Cell Biology
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Molecular Biology
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#1817
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Philosophy Biology
Jean‐dominique Vassalli's Degrees
- Doctorate Medicine University of Geneva
- PhD Biochemistry University of Geneva
Why Is Jean‐dominique Vassalli Influential?
(Suggest an Edit or Addition)Jean‐dominique Vassalli's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The plasminogen activator/plasmin system. (1991) (1207)
- Basic fibroblast growth factor induces angiogenesis in vitro. (1986) (823)
- A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase (1985) (714)
- Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors (1987) (608)
- The 3′ untranslated region of messenger RNA: A molecular ‘hotspot’ for pathology? (2000) (545)
- Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors (1986) (537)
- The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes (1990) (483)
- Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro (1990) (448)
- Concomitant secretion of prourokinase and of a plasminogen activator- specific inhibitor by cultured human monocytes-macrophages (1984) (412)
- Macrophage plasminogen activator: Modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides (1976) (394)
- Amiloride selectively inhibits the urokinase‐type plasminogen activator (1987) (385)
- Extracellular proteolysis in the adult murine brain. (1993) (369)
- Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis (1993) (324)
- Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles (1986) (319)
- Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles (1987) (319)
- Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos (1989) (291)
- Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells (1987) (291)
- Upregulation of urokinase receptor expression on migrating endothelial cells (1993) (291)
- Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells (*) (1995) (289)
- Enhanced hippocampal long‐term potentiation and learning by increased neuronal expression of tissue‐type plasminogen activator in transgenic mice (1999) (287)
- Testis determination requires insulin receptor family function in mice (2003) (284)
- Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. (2005) (277)
- Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. (1991) (266)
- Direct identification of prohormone conversion site in insulin-secreting cells (1985) (263)
- Transient translational silencing by reversible mRNA deadenylation (1992) (243)
- Macrophage plasminogen activator: induction by concanavalin A and phorbol myristate acetate (1977) (234)
- Characterization of the cellular binding site for the urokinase-type plasminogen activator. (1989) (233)
- Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes. (1989) (233)
- Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937. (1986) (232)
- Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors (1977) (231)
- Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. (1996) (226)
- TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. (1994) (220)
- Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA. (1987) (208)
- Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. (1985) (195)
- Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism (2008) (190)
- Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney. (1991) (173)
- Membrane proteases in focus (1994) (173)
- Plasminogen activator-specific inhibitors produced by human monocytes/macrophages (1987) (170)
- Plasminogen activator in mouse and rat oocytes: Induction during meiotic maturation (1985) (162)
- Antisense RNA directed against the 3' noncoding region prevents dormant mRNA activation in mouse oocytes. (1988) (157)
- Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes (1992) (156)
- Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. (1994) (156)
- Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas. (1987) (152)
- Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. (1996) (142)
- Facultative polypeptide translocation allows a single mRNA to encode the secreted and cytosolic forms of plasminogen activators inhibitor 2. (1989) (140)
- A clathrin-coated, golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin (1984) (138)
- Dicer1 Depletion in Male Germ Cells Leads to Infertility Due to Cumulative Meiotic and Spermiogenic Defects (2011) (135)
- The Urokinase Receptor (1994) (134)
- Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors (1987) (129)
- Macrophage plasminogen activator: induction by products of activated lymphoid cells (1977) (129)
- Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface (1987) (127)
- TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. (1995) (126)
- Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. (1998) (115)
- A Phytoestrogen-Rich Diet Increases Energy Expenditure and Decreases Adiposity in Mice (2007) (112)
- Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. (2004) (110)
- Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. (1993) (108)
- Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition. (1997) (103)
- A two‐step recognition of signal sequences determines the translocation efficiency of proteins. (1996) (101)
- Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. (2007) (98)
- Angiogenesis-regulating cytokines: activities and interactions. (1996) (97)
- Urokinase‐type plasminogen activator and its receptor synergize to promote pathogenic proteolysis (2000) (97)
- Differential protease expression by cutaneous squamous and basal cell carcinomas. (1991) (95)
- An accumulation of p34cdc2 at the end of mouse oocyte growth correlates with the acquisition of meiotic competence. (1996) (94)
- Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis (1994) (90)
- Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids (1976) (89)
- Acquisition of meiotic competence in growing mouse oocytes is controlled at both translational and posttranslational levels. (1997) (86)
- Specific protease deficiency in polymorphonuclear leukocytes of Chediak- Higashi syndrome and beige mice (1978) (81)
- Plasminogen activators and their inhibitors in a human mammary cell line (HBL-100). Modulation by glucocorticoids. (1986) (77)
- The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. (2012) (77)
- Chondrocytes inhibit endothelial sprout formation in vitro: Evidence for involvement of a transforming growth factor‐beta (1991) (76)
- Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice (2010) (74)
- Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription. (1987) (74)
- Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases (1988) (73)
- Urokinase-catalyzed plasminogen activation at the monocyte/macrophage cell surface: a localized and regulated proteolytic system. (1992) (72)
- Plasminogen activator of islets of Langerhans: modulation by glucose and correlation with insulin production. (1980) (71)
- mRNA for tissue-type plasminogen activator is present in lesional epidermis from patients with psoriasis, pemphigus, or bullous pemphigoid, but is not detected in normal epidermis. (1990) (71)
- Calcitonin stimulates plasminogen activator in porcine renal tubular cells: LLC-PK1 (1981) (69)
- Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain (1993) (66)
- Protease‐nexin I as an androgen‐dependent secretory product of the murine seminal vesicle. (1993) (64)
- RNA and protein synthesis in human peripheral blood polymorphonuclear leukocytes (1979) (64)
- The kidney is a major site of alpha(2)-antiplasmin production. (1996) (63)
- Plasminogen activator is a mitogen for astrocytes in developing cerebellum. (1985) (62)
- Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis. (1995) (58)
- Involvement of the plasminogen activator/plasmin proteolytic cascade in fertilization. (1993) (58)
- Calcitonin and calcitonin gene-related peptide interact with the same receptor in cultured LLC-PK1 kidney cells. (1985) (57)
- Glucocorticoid modulation of plasminogen activators and of one of their inhibitors in the human mammary carcinoma cell line MDA-MB-231. (1987) (57)
- Plasminogen activator-specific inhibitors in mouse macrophages: in vivo and in vitro modulation of their synthesis and secretion. (1987) (56)
- Nonconverted, amino acid analog-modified proinsulin stays in a Golgi- derived clathrin-coated membrane compartment (1984) (55)
- Dcp1-bodies in mouse oocytes. (2009) (54)
- Plasminogen activation in melanocytic neoplasia. (1994) (54)
- Translational Control: Awakening dormant mRNAs (1995) (51)
- Two transgenic approaches to define the cell lineages in endocrine pancreas development (1998) (51)
- Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice. (2001) (47)
- Tumour biology. Membrane proteases in focus. (1994) (46)
- The insulin factory. (1988) (44)
- Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity (1981) (43)
- Tumor promoter PMA stimulates the synthesis and secretion of mouse pro‐urokinase in MSV‐transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content. (1984) (42)
- Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation (2011) (40)
- Evidence for polarization of plasma membrane domains in pancreatic endocrine cells (1985) (39)
- Plasminogen activators in the mouse mammary gland. Decreased expression during lactation. (1989) (38)
- Complementary pathways in mammalian female sex determination (2009) (36)
- LLC‐PK1 cysts: A model for the study of epithelial polarity (1985) (35)
- Human and murine urokinase cDNAs linked to the murine alpha A-crystallin promoter exhibit lens and non-lens expression in transgenic mice. (1990) (34)
- Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes. (1987) (32)
- LLC-PK1 cells: cloning of phenotypically stable subpopulations. (1986) (31)
- Modulation of angiogenesis in vitro. (1992) (29)
- LPS induces major changes in the extracellular proteolytic balance in the murine kidney. (1994) (28)
- Plasminogen activator inhibitor-1 is induced in microvascular endothelial cells by a chondrocyte-derived transforming growth factor-beta. (1991) (28)
- Tissue plasminogen activator in psoriasis. (1990) (26)
- Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression. (2004) (26)
- Processing of complex between urokinase and its type‐2 inhibitor on the cell surface (1993) (26)
- Okadaic acid and p13suc1 modulate the reinitiation of meiosis in mouse oocytes (1992) (25)
- The Redesigned Undergraduate Medical Curriculum at the University of Geneva (1997) (25)
- Inducible and irreversible control of gene expression using a single transgene. (2000) (24)
- Extracellular proteolysis alters tooth development in transgenic mice expressing urokinase-type plasminogen activator in the enamel organ. (1999) (23)
- Polarized secretion of urokinase-type plasminogen activator by epithelial cells. (1992) (22)
- Cuts and scrapes? Plasmin heals! (1996) (21)
- In vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes (1997) (21)
- Plasmin-catalyzed proteolysis in colorectal neoplasia. (1995) (21)
- Beta- and Gamma-Cytoplasmic Actins Are Required for Meiosis in Mouse Oocytes1 (2011) (20)
- Insulin Receptor and IGF1R Are Not Required for Oocyte Growth, Differentiation, and Maturation in Mice (2009) (19)
- Expression of Serpinb6 serpins in germ and somatic cells of mouse gonads (2006) (19)
- Ultrastructural localization of glycocalyx domains in human kidney podocytes using the lectin-gold technique. (1985) (17)
- Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription. (1989) (17)
- An Inhibitor of Serine Proteases, Neuroserpin, Acts as a Neuroprotective Agent in a Mouse Model of Neurodegenerative Disease (2006) (17)
- Emotions are building up in the field of extracellular proteolysis. (2003) (16)
- Lipolysis and alpha-aminoisobutyric acid uptake in isolated fat cells. Effects of insulin and lipolytic agents. (1970) (16)
- Proteolytic balance and capillary morphogenesis in vitro. (1992) (15)
- Protease nexin 1 in the murine kidney: glomerular localization and up-regulation in glomerulopathies. (1996) (13)
- Regional heterogeneity of glycoconjugate distribution in the glomerulus revealed by lectin-gold cytochemistry and SDS-PAGE. (1986) (13)
- Colcemid and related alkaloids inhibit lectin-mediated stimulation of RNA synthesis in human peripheral blood lymphocytes. (1977) (12)
- The serpin Spn5 is essential for wing expansion in Drosophila melanogaster. (2008) (12)
- Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis (1994) (11)
- Direct cell-to-cell transmission of vesicular stomatitis virus. (1986) (10)
- Platelet-derived factors enhance pemphigus acantholysis in skin organ cultures. (1986) (9)
- Building a multisystemic understanding of societal resilience to the COVID-19 pandemic (2021) (8)
- A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice (1994) (8)
- [Of epigenetics and development]. (2007) (8)
- Neutral proteinases of leucocytes and the inflammatory process. (1979) (8)
- PACS1-Neurodevelopmental disorder: clinical features and trial readiness (2021) (8)
- High levels of complement breakdown products in tuberculous pleural effusions. (1983) (8)
- Neuronal overexpression of tissue‐type plasminogen activator does not enhance sensory axon regeneration or locomotor recovery following dorsal hemisection of adult mouse thoracic spinal cord (2006) (6)
- Induction of enhanced green fluorescent protein expression in response to lesions in the nervous system (2004) (6)
- Plasmin induces acantholysis in skin organ cultures (2004) (6)
- [The current curriculum in medicine at the University of Geneva]. (1997) (5)
- Microinjecting antisense sequences into oocytes. (1993) (4)
- Transcriptional and post-transcriptional profile of human chromosome 21. (2009) (4)
- Plasminogen activation in melanocytic neoplasia: 328 (1993) (2)
- Urokinase-type plasminogen activator mRNA in implanting murine embryos (1989) (2)
- [Impact of the COVID-19 pandemic on adolescent health and development: a role to play for physicians]. (2021) (2)
- 3′ UTR Mutations and Human Disorders (2006) (2)
- Role of tissue type plasminogen activator in TBI (2010) (1)
- Modulation of Macrophage Plasminogen Activator Secretion (1980) (1)
- The Kidney Is a Major Site of a 2-Antiplasmin Production (2013) (1)
- Plasmin-catalyzed Proteolysis in Colorectal Neoplasia1 (2006) (0)
- CONCOMITANT S ECRETION O F P ROUROKINASE A ND O F A PLASMINOGEN A CTIVATOR-SPECIF IC I NHIBITOR BY CULTURED H UMAN M ONOCYTES-MACROP HAGES (1984) (0)
- Cerebellum produces two distinct forms of plasminogen activator (1985) (0)
- 8 Plasminogen activation by cutaneous squamous and basal cell carcinomas (1991) (0)
- Expression in transgenic mice of hybrid genes comprising the human or murine urokinase cDNA fused to the alpha-A-crystalijn promoter (1989) (0)
- Proteolytic balance and capillary morphogenesis in vitro (1991) (0)
- A CELLULAR RECEPTOR FOR UROKINASE-TYPE PLASMINOGEN ACTIVATOR (1987) (0)
- Tissue plasminogen activator in psoriasis. (1990) (0)
- [Ultrastructural detection of the heterogeneity of glycocalyx in convoluted and straight proximal tubules of rat kidney by the lectin-gold complex technic]. (1983) (0)
- Approaches to study translational control in mouse oocytes. (1999) (0)
- Expression of the alpha 2-antiplasmin gene in adult murine tissues (1994) (0)
- Differential targeting of two forms of plasminogen activator inhibitor 2 is caused by a facultative signal peptide (1989) (0)
- Translation Control in Oocytes: A Critical Role for the Poly(A) Tail of Maternal mRNAs (1993) (0)
- The impact of the Ebola epidemics on children’s rights: a scoping review (2022) (0)
- Union of Swiss Societies of Experimental Biology (2005) (0)
- Biochemical characteristics and polarized expression of the u-PA receptor at the cell surface (1989) (0)
- Modulation of an early and lethal autoimmune diabetes in transgenic mice by IL-4 overexpression and treatment with anti-IFN-γ antibody (1999) (0)
- mRNA for tissue plasminogen activator is present in lesional but is not detected in normal human epidermis (1989) (0)
- Table of Contents (1996) (0)
- The use of antisense and chimeric RNA injection to study translational regulation of mRNA in mouse oocytes (1989) (0)
- Beta- and Gamma-Cytoplasmic Actins Are Required for Meiosis in Mouse Oocytes 1 (2022) (0)
- [Plasminogen activation: multifunctional proteolytic cascade]. (1992) (0)
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