Joseé E. Leysen
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Most Influential Person Across History
Joseé E. Leysen's AcademicInfluence.com Rankings
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Medical Philosophy
Joseé E. Leysen's Degrees
- PhD Pharmacology University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
Why Is Joseé E. Leysen Influential?
(Suggest an Edit or Addition)Joseé E. Leysen's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role. (1982) (1011)
- Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. (1981) (836)
- Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding (1996) (826)
- Serotonergic component of neuroleptic receptors (1977) (639)
- Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding. (1978) (528)
- Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonist. (1985) (449)
- Biochemical profile of risperidone, a new antipsychotic. (1988) (405)
- Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity. (1979) (400)
- Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. (1994) (312)
- 5-HT2 receptors. (2004) (242)
- Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography (1993) (214)
- Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites. (1985) (213)
- 5-HT2A and 5-HT2C receptors and their atypical regulation properties. (2003) (209)
- 5-HT7 receptors: current knowledge and future prospects. (2000) (202)
- [3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord. (1983) (184)
- Expression and regulation of interleukin‐10 and interleukin‐10 receptor in rat astroglial and microglial cells (2002) (178)
- Spiperone: a ligand of choice for neuroleptic receptors. 2. Regional distribution and in vivo displacement of neuroleptic drugs. (1978) (167)
- The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. (2001) (154)
- Nuclei and subnuclei gene expression profiling in mammalian brain (2002) (153)
- In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone. (1992) (146)
- Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors (2005) (143)
- Structure of the Human Serotonin 5‐HT4 Receptor Gene and Cloning of a Novel 5‐HT4 Splice Variant (2000) (137)
- Survey on the pharmacodynamics of the new antipsychotic risperidone (1994) (128)
- Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. (1993) (127)
- Optimal Conditions for [3H]Apomorphine Binding and Anomalous Equilibrium Binding of [3H]Apomorphine and [3H]Spiperone to Rat Striatal Membranes: Involvement of Surface Phenomena Versus Multiple Binding Sites (1981) (126)
- Regional brain distribution of risperidone and its active metabolite 9-hydroxy-risperidone in the rat (1994) (124)
- Serotonin-S2 receptor binding sites and functional correlates (1984) (124)
- Apomorphine: chemistry, pharmacology, biochemistry. (1976) (123)
- Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function (1997) (119)
- The Receptor Binding Profile of the New Antihypertensive Agent Nebivolol and its Stereoisomers Compared with Various β-Adrenergic Blockers (1988) (113)
- Differences in Signal Transduction of Two 5-HT4Receptor Splice Variants: Compound Specificity and Dual Coupling with Gαs- and Gαi/o-Proteins (2002) (112)
- Evidence for functional 5-HT2 receptor sites on human blood platelets. (1984) (111)
- [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. (2003) (110)
- Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions (2003) (109)
- Rapid desensitization and down-regulation of 5-HT2 receptors by DOM treatment. (1989) (104)
- Molecular cloning and pharmacological characterization of a molluscan octopamine receptor. (1997) (104)
- Specific in vivo binding of neuroleptic drugs in rat brain. (1977) (98)
- Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. (1996) (95)
- Ca++ and Na+ channels involved in neuronal cell death. Protection by flunarizine. (1991) (95)
- In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole. (1982) (92)
- Mapping of serotonin 5‐HT4 receptor mRNA and ligand binding sites in the post‐mortem human brain (2000) (91)
- Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus (1992) (90)
- In vivo binding of [3H]ketanserin on serotonin S2-receptors in rat brain. (1982) (86)
- Differential distribution of opiate and neuroleptic receptors and dopamine-sensitive adenylate cyclase in rat brain. (1977) (85)
- Does phenylethylamine act as an endogenous amphetamine in some patients? (1999) (84)
- Spiperone: a ligand of choice for neuroleptic receptors. 3. Subcellular distribution of neuroleptic drugs and their receptors in various rat brain areas. (1978) (82)
- Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease. (1988) (82)
- In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. (1995) (82)
- Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells. (1993) (82)
- Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine. (1989) (81)
- Serotonergic receptor subtypes and vascular reactivity. (1984) (79)
- Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. (2000) (78)
- The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells. (1998) (78)
- Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. (1996) (75)
- Drug‐receptor dissociation time, new tool for drug research: Receptor binding affinity and drug‐receptor dissociation profiles of serotonin‐S2, Dopamine‐D2, histamine‐H1 antagonists, and opiates (1986) (75)
- Differentiation of opiate and neuroleptic receptor binding in rat brain. (1977) (75)
- Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127 (2004) (73)
- Detailed distribution of Neurokinin 3 receptors in the rat, guinea pig and gerbil brain: a comparative autoradiographic study (2001) (73)
- 5‐HT2 Receptors, Roles and Regulation (1990) (73)
- Demonstration of S2-receptor binding sites on cat blood platelets using [3H]ketanserin. (1983) (73)
- Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat (2004) (72)
- STEREOSPECIFIC IN VlTRO BINDING OF [3H]DEXETIMIDE TO BRAIN MUSCARINIC RECEPTORS (1979) (71)
- Dopamine receptor‐mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and time (2004) (70)
- Interaction of des-tyrosine-γ-endorphin (DTγE,β-LPH62–77) with neuroleptic binding sites in various areas of rat brain (1978) (70)
- Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain. (2000) (69)
- Daphnane-type diterpene orthoesters and their biological activities. (2002) (68)
- Stimulation of D2-receptors in rat nucleus accumbens slices inhibits dopamine and acetylcholine release but not cyclic AMP formation (1987) (68)
- The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors. (1999) (67)
- Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3). (1998) (67)
- Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin- and tetrabenazine-like drugs. (1988) (67)
- Problems in in vitro receptor binding studies and identification and role of serotonin receptor sites (1984) (64)
- Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. (2009) (64)
- Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants. (1999) (62)
- Cloning and Expression of a Human Serotonin 5‐HT4 Receptor cDNA (1997) (61)
- Gaps and peculiarities in 5-HT2 receptor studies. (1990) (60)
- Platelet 3H-paroxetine binding in depressed patients (1988) (60)
- Use of 5-HT Receptor Agonists and Antagonists for the Characterization of Their Respective Receptor Sites (1989) (60)
- Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists. (2001) (59)
- Symposium on: receptors of dopamine antagonists: new biochemical approaches. July 6-8, 1978, Beerse, Belgium. (1978) (59)
- Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand. (1997) (59)
- Functional characterisation of a 5-HT2 receptor cDNA cloned from Lymnaea stagnalis. (1996) (58)
- Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonists (1983) (57)
- Comparison of the ligand binding and signaling properties of human dopamine D(2) and D(3) receptors in Chinese hamster ovary cells. (1999) (56)
- Comparison of the In‐vitro Receptor Selectivity of Substituted Benzamide Drugs for Brain Neurotransmitter Receptors (1988) (55)
- Autoradiographic evidence for the occlusion of rat brain dopamine D3 receptors in vivo. (1992) (53)
- Radiosynthesis of a new radioiodinated ligand for serotonin‐5HT2‐receptors, a promising tracer for γ‐emission tomography (1994) (53)
- Role and localization of serotonin2 (S2)-receptor-binding sites: effects of neuronal lesions. (1983) (52)
- Receptor occupancy by ritanserin and risperidone measured using ex vivo autaradiography (1989) (50)
- New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants. (2000) (49)
- The serotonin‐S2 Receptor: A receptor‐transducer coupling model to explain insurmountable antagonist effects (1986) (48)
- Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels. (1990) (48)
- Neuroprotective sigma ligands interfere with the glutamate‐activated NOS pathway in hippocampal cell culture (1995) (46)
- Effects of some derivatives of 2-aminotetralin on dopamine-sensitive adenylate cyclase and on the binding of (3H)haloperidol to neuroleptic receptors in the rat striatum. (1978) (45)
- [3H]Batrachotoxinin A 20-alpha-benzoate binding to sodium channels in rat brain: characterization and pharmacological significance. (1986) (45)
- Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5‐HT1B and 5‐HT1D receptors expressed in various mammalian cell lines (1998) (45)
- Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain (1986) (44)
- Melatonin modulates the sensitivity of 5-hydroxytryptamine-2 receptor-mediated sleep—wakefulness regulation in the rat (1989) (44)
- Is the low incidence of extrapyramidal side‐effects of antipsychotics associated with antimuscarinic properties? (1978) (43)
- Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone (2004) (43)
- Neurotransmitters and receptor binding in amygdaloid kindled rats: serotonergic and noradrenergic modulatory effects. (1980) (43)
- Restricted usefulness of tetraethylammonium and 4‐aminopyridine for the characterization of receptor‐operated K+ ‐channels (1989) (42)
- Different kinetic properties of neuroleptic receptor binding in the rat striatum and frontal cortex. (1978) (42)
- Binding of [3H]paroxetine to platelets of depressed patients: seasonal differences and effects of diagnostic classification. (1994) (42)
- The involvement of 5-HT2-receptor sites in the activation of cat platelets. (1984) (42)
- Functional study of rat 5‐HT2A receptors using antisense oligonucleotides (2003) (41)
- Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins. (2002) (40)
- Autoradiographic evidence for the localization of high affinity neurotensin binding sites on dopaminergic nerve terminals in the nigrostriatal and mesolimbic pathways in rat brain. (1989) (40)
- 5HT1B and 5HT1D receptor mRNA differential co‐localization with peptide mRNA in the guinea pig trigeminal ganglion (1998) (39)
- N-methylation of biogenic amines. I. Characterization and properties of an N-methyltransferase in rat brain using 5-methyltetrahydrofolic acid as the methyl donor. (1974) (39)
- Co-localization of 5-HT1B- and 5-HT1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphé nucleus: a double labeling in situ hybridization histochemistry study (1998) (39)
- Characterization of an enzyme yielding formaldehyde from‐5‐methyltetrahydrofolic acid (1974) (39)
- Non-serotonergic [3H]ketanserin binding sites in striatal membranes are associated with a dopac release system on dopaminergic nerve endings. (1987) (38)
- Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain (2002) (37)
- Evaluation of the tetracycline‐ and ecdysone‐inducible systems for expression of neurotransmitter receptors in mammalian cells (2001) (37)
- Interaction of peptides and morphine-like narcotic analgesics with specifically labelled mu- and delta-opiate receptor binding sites. (1983) (37)
- The dissociation rate of unlabelled dopamine antagonists and agonists from the dopamine-D2 receptor, application of an original filter method. (1984) (36)
- Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors. (1997) (36)
- Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii. (2002) (35)
- Human 5-hydroxytryptamine(5A) receptors activate coexpressed G(i) and G(o) proteins in Spodoptera frugiperda 9 cells. (2000) (35)
- Initial evaluation of123I-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects (1997) (35)
- Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells. (1990) (35)
- Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii. (2000) (34)
- Endogenous dopamine limits the binding of antipsychotic drugs to D3 receptors in the rat brain: a quantitative autoradiographic study (1996) (34)
- Chapter 1. Biochemical Models for Serotonin Receptors (1982) (34)
- Characterization of specific in vivo binding of neuroleptic drugs in rat brain. (1978) (33)
- Vesamicol and some of its derivatives: questionable ligands for selectively labelling acetylcholine transporters in rat brain. (1997) (33)
- Synthesis and biodistribution of [11C]R107474, a new radiolabeled alpha2-adrenoceptor antagonist. (2006) (33)
- Regional distribution of serotonin-2 receptor binding sites in the brain and effects of neuronal lesions. (1982) (33)
- Subtype (2020) (32)
- Receptor profile of antipsychotics (2000) (32)
- Role of 5-HT2 receptors in the tryptamine-induced 5-HT syndrome in rats (2002) (32)
- Etomidate stereospecifically stimulates forebrain, but not cerebellar, 3H-diazepam binding. (1981) (31)
- Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand. (2006) (31)
- Review on neuroleptic receptors: specificity and multiplicity of in vitro binding related to pharmacological activity (1981) (30)
- Distinction between dopaminergic and serotonergic components of neuroleptic binding sites in limbic brain areas. (1979) (30)
- Subcellular localization of dopamine-sensitive adenylate cyclase in rat brain striatum. (1976) (30)
- Serotonergic responses in vascular and non-vascular tissues. (1982) (29)
- Seasonal Variation in Platelet [3H]Paroxetine Binding in Healthy Volunteers (1996) (29)
- Epidural and Intravenous Sufentanil in the Rat: Analgesia, Opiate Receptor Binding, and Drug Concentrations in Plasma and Brain (1986) (28)
- Evaluation of radioiodo-4-amino-N-[1-[3-(4-fluorophenoxy)-propyl]-4- methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide as a potential 5HT2 receptor tracer for SPE(C)T. (1995) (28)
- Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. (2011) (28)
- G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure. (2000) (28)
- Reconstitution of the human 5-HT(1D) receptor-G-protein coupling: evidence for constitutive activity and multiple receptor conformations. (2000) (28)
- Attenuation of neurotoxicity following anoxia or glutamate receptor activation in EGF- and hippocampal extract-treated neuronal cultures. (1989) (27)
- Blockade of apomorphine's discriminative stimulus properties: Relation to neuroleptic activity in neuropharmacological and biochemical assays (1976) (27)
- Distinct autoradiographic labelling of serotonin 5-HT2 receptors, alpha 1-adrenoceptors and histamine-H1 receptors and of tetrabenazine-displaceable ketanserin binding sites in rodent brain with [125I]7-amino-8-iodo-ketanserin. (1988) (27)
- Synthesis of cisapride, a gastrointestinal stimulant derived from cis‐4‐amino‐3‐methoxypiperidine (1986) (27)
- KETANSERIN: A SELECTIVE ANTAGONIST OF 5-HT2 SEROTONINERGIC RECEPTORS (1983) (26)
- Ten years of antisense inhibition of brain G-protein-coupled receptor function (2003) (26)
- Human β1- and β2-adrenergic receptor binding and mediated accumulation of cAMP in transfected chinese hamster ovary cells: Profile of nebivolol and known β-adrenergic blockers (1991) (26)
- Enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: prior step to alkaloid formation. (1975) (26)
- Further validation of in vivo and in vitro pharmacological procedures for assessing the α2/α1-selectivity of test compounds: (1) α-adrenoceptor antagonists (1986) (24)
- Identification of alkaloids; the condensation products of biogenic amines with formaldehyde, enzymatically formed from 5-methyltetrahydrofolic acid. (1975) (24)
- Effects of recent and reference antipsychotic agents at human dopamine D2 and D3 receptor signaling in Chinese hamster ovary cells (2000) (23)
- Preclinical evaluation of [(18)F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors. (2015) (23)
- Opposite regulation of serotonin-S2 and dopamine-D2 receptors in rat brain following chronic receptor blockade. (1987) (23)
- Receptor cloning and heterologous expression--towards a new tool for drug discovery. (1993) (23)
- Pharmacological Profile of (2R-trans)-4-[1-[3,5-bis(Trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an Orally and Centrally Active Neurokinin-1 Receptor Antagonist (2002) (23)
- Identification of 5-HT2 receptors, alpha 1-adrenoceptors and amine release sites in rat brain by autoradiography with [125I]7-amino-8-iodo-ketanserin. (1989) (22)
- Radiosynthesis and preclinical evaluation of ( 11 C) (2013) (22)
- The Dopamine Stabilizer (−)-OSU6162 Occupies a Subpopulation of Striatal Dopamine D2/D3 Receptors: An [11C]Raclopride PET Study in Healthy Human Subjects (2015) (21)
- Internalization of Human 5-HT4a and 5-HT4b Receptors is Splice Variant Dependent (2004) (21)
- Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2′-iodospiperone (2005) (21)
- Solubilization of rat brain serotonin-S2 receptors using CHAPS/salt. (1985) (20)
- The discovery of a series of new non-indole 5HT1D agonists (1995) (20)
- Erratum: Initial evaluation of 123 I-5-I-R91150, a selective 5-HT(2A) ligand for single-photon emission tomography, in healthy human subjects (European Journal of Nuclear Medicine (1997) 24 (119-124)) (1997) (20)
- Initial evaluation of 123I-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects. (1997) (19)
- Partition of Ca2+ antagonists in brain plasma membranes. (1989) (19)
- Chronic treatment with sabeluzole protects cultured rat brain neurons from the neurotoxic effects of excitatory amino acids (1992) (19)
- Photoaffinity probes for serotonin and histamine receptors. Synthesis and characterization of two azide analogues of ketanserin. (1985) (19)
- Chronic neuroleptic treatment specifically alters the number of dopamine receptors in rat brain. (1981) (19)
- Evidence that pimozide is not a partial agonist of dopamine receptors. (1979) (18)
- Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor. (2006) (18)
- Striatal dopamine receptors in rats displaying long‐term behavioural sensitization to morphine (1997) (18)
- Partition coefficients of dopamine antagonists in brain membranes and liposomes. (1989) (18)
- Aminergic receptors in astrogliotic plaques from patients with multiple sclerosis (2002) (17)
- [11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors (2013) (17)
- Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template (2012) (17)
- Synthesis and biological activities of psi (CH2NH) pseudopeptide analogues of the C-terminal hexapeptide of neurotensin. (2009) (17)
- Receptor interactions of dopamine and serotonin antagonists: binding in vitro and in vivo and receptor regulation. (1988) (17)
- Synthesis and biodistribution of [11C]R116301, a promising PET ligand for central NK1 receptors (2005) (17)
- Differential regulation of dopamine-D2 and serotonin-S2 receptors by chronic treatment with the serotonin-S2 antagonists, ritanserin, and setoperone. (1987) (16)
- Binding properties of 3H-lofentanil at the opiate receptor. (1982) (16)
- Labelling and evaluation of new stabilised neurotensin (8–13) analogues for single photon emission tomography (SPET) (1999) (16)
- Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors. (2014) (16)
- Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. (2001) (15)
- Specific effect of haloperidol on dopamine turnover in the frontal cortex (2004) (15)
- Identification of non-serotonergic [3H]ketanserin binding sites on human platelets and their role in serotonin release. (1991) (14)
- Comparative study of central and peripheral histamine‐H1 receptor binding in vitro and ex vivo of non‐sedating antihistamines and of noberastine, a new agent (1991) (14)
- Serotoninergic receptors in brain tissue: properties and identification of various 3H-ligand binding sites in vitro. (1981) (14)
- Intermittent morphine treatment causes long-term desensitization of functional dopamine D2 receptors in rat striatum. (1995) (14)
- In vitro Pharmacological Profile of 3-N-(2-Fluoroethyl)Spiperone (1990) (14)
- Serotonin receptor binding sites: is there pharmacological and clinical significance? (1983) (14)
- Reductive N‐alkylation of secondary amines with [2‐11C]acetone (2003) (14)
- Substance dependence. (1998) (13)
- Further characterization of neurotensin binding in the rat brain: levocabastine-displaceable neurotensin binding sites are not histamine-H1 receptors. (1989) (13)
- Synthesis and biological activities of linear and cyclic enkephalin analogues containing a psi (E,CH = CH) or psi (CH2CH2) isosteric replacement. (2009) (13)
- Ketanserin reduces a particular monoamine pool in peripheral tissues. (1989) (12)
- Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization. (1999) (12)
- Depolarization of chick myotubes triggers the appearance of (+)-[3H]PN 200-110-binding sites. (1987) (12)
- Narcotic Dosage and Central Nervous System Opiate Receptor Binding (1983) (12)
- Distinction between adrenergic and serotonergic receptor subtypes: specificity of drugs and absence of cooperative interactions between adrenergic and serotonergic receptor binding sites. (1988) (11)
- Beta-adrenoceptor-mediated cAMP accumulation in cardiac cells: effects of nebivolol. (1989) (11)
- Bilateral control of brain activity by dopamine D1 receptors: Evidence from induction patterns of regulator of G protein signaling 2 and c-fos mRNA in D1-challenged hemiparkinsonian rats (2005) (11)
- In vitro binding properties of 3H-sufentanil, a superior ligand for the mu-opiate receptor. (1982) (11)
- Towards an improved survival of rat brain neurons in culture by cerebrospinal fluid of patients with senile dementia of Alzheimer's type (1993) (11)
- Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo (1990) (10)
- Receptor binding properties in vitro and in vivo of some long-acting opiates. (1978) (10)
- Central and Peripheral 5-HT2Receptors: Role in Physiological Versus Pathological Conditions (1990) (10)
- Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system. (1997) (10)
- Sleeplessness (1885) (10)
- Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor (2013) (9)
- N-methylation of indolealkylamines in the brain with a new methyl donor. (1974) (9)
- Muscarinic receptor: multiple sites or unitary concept? (1981) (9)
- Novel computational model for the interaction of dopamine with the D2 receptor. (1993) (9)
- Identification of beta-adrenoceptors in bovine teat muscles by 3H-dihydroalprenolol binding. (1984) (9)
- Optimized expression of serotonin receptors in mammalian cells using inducible expression systems (1999) (9)
- Human beta 1- and beta 2-adrenergic receptor binding and mediated accumulation of cAMP in transfected Chinese hamster ovary cells. Profile of nebivolol and known beta-adrenergic blockers. (1991) (9)
- Reconstitution of human 5-hydroxytryptamine5A receptor--G protein coupling in E. coli and Sf9 cell membranes with membranes from Sf9 cells expressing mammalian G proteins. (2001) (9)
- Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells. (2002) (9)
- Agonist-induced desensitization of 5-HT2 receptors on cultured calf aortic smooth muscle cells (1988) (9)
- Receptor-based assays. (1991) (8)
- Pharmacokinetic evaluation of the in vitro and in vivo pharmacological profile of the major metabolites of ketanserin in the rat. (1988) (8)
- Radiosynthesis and biological evaluation of the M1 muscarinic acetylcholine receptor agonist ligand [11C]AF150(S) (2012) (8)
- Differential photoaffinity labelling of serotonin‐S2 receptors and histamine‐H1 receptors using 7‐azidoketanserin (1985) (8)
- The light-dark cycle modulates the effects of ritanserin on sleep-wakefulness patterns in the rat (1989) (8)
- MK-801 alters RGS2 levels and adenylyl cyclase sensitivity in the rat striatum (2005) (7)
- Discrimination of narcotic drugs on 3H-fentanyl receptor binding. (1976) (7)
- Effects of lesions on 3H-apomorphine and 3H-spiperone stereospecific binding sites in subcellular fractions of rat striatum (1981) (7)
- 71 – DOMPERIDONE, A NOVEL GASTROKINETIC AND ANTI-NAUSEANT DRUG, INTERACTS SELECTIVELY WITH DOPAMINE RECEPTORS (1978) (7)
- First Evaluation of [11C]R116301 as an In Vivo Tracer of NK1 Receptors in Man (2009) (7)
- The dissociation rate of unlabelled drugs from receptor sites: a poorly investigated, yet important aspect in receptor research. Studies on the serotonin-S2 receptor. (1988) (7)
- Lipophilic nalmefene prodrugs to achieve a one-month sustained release. (2016) (7)
- Antagonist‐induced supersensitivity of mGlu1 receptor signalling in cerebellar granule cells (2005) (6)
- Further validation of in vivo and in vitro pharmacological procedures for assessing the alpha 2/alpha 1-selectivity of test compounds: (2). Alpha-adrenoceptor agonists. (1986) (6)
- Symposium on: receptors of dopamine antagonists: new biochemical approaches. July 6--8, 1978, Beerse, Belgium. (1978) (6)
- In vivo formation of epinine in adrenal medulla (1974) (6)
- Comparative Study of the Binding Properties of Cloned Human β1- and β2-Adrenergic Receptors Expressed in Escherichia coli (1991) (6)
- Studies in organic mass spectrometry. XV. Mass fragmentographic identification of epinine in adrenal medulla and as a product of an in vitro enzymic methylation. (1974) (5)
- Receptors: binding assays (2010) (5)
- 3H-Apomorphine receptors in various rat brain regions: a study of specific and nonspecific binding and the influence of chronic neuroleptic treatment. (1980) (5)
- Unitary dopaminergic receptor composed of cooperatively linked agonist and antagonist sub-unit binding sites. (1979) (5)
- A serotonergic component of neuroleptic receptors. (1977) (5)
- Evidence for, and localization of, a unitary dopamine receptor composed of cooperatively linked subunit binding sites in rat striatum. (1979) (4)
- Thromboxane A2/prostaglandin endoperoxide (TXA2/PG‐END) receptor binding properties in human platelets of ridogrel, a combined TXA2 synthase inhibitor—TXA2/PG‐END receptor antagonist (1991) (4)
- Role and localization of serotonin-5HT2 receptors. (1992) (4)
- THE INFLUENCE OF DIAZEPAM AND DROPERIDOL ON CNS RECEPTOR BINDING (1980) (4)
- New 2-Substituted 1,2,3,4-Tetrahydrobenzofuro[3,2-c]pyridine Having Highly Active and Potent Central α2-Antagonistic Activity as Potential Antidepressants. (2000) (4)
- Subchronic treatment with phencyclidine in adolescence leads to impaired exploratory behavior in adult rats without altering social interaction or N‐methyl‐D‐aspartate receptor binding levels (2014) (4)
- Quantification of the neurokinin 1 receptor ligand [11C]R116301 (2011) (4)
- Radiosynthesis and biodistribution of [11C]R107474 as a potential pet ligand for central α2‐adrenoceptors (2001) (3)
- Transgenic Animal (2020) (3)
- Solubilized opiate receptors labelled with 3H-lofentanil. (1982) (3)
- Ontogenetic development of a 5-methyltetrahydrofolate requiring enzyme in rats and mice (2004) (3)
- Photoaffinity labelling of serotonin-S2 receptors with 7-azidoketanserin. (1985) (3)
- Synthesis and biodistribution of [(11)C]R116301, a promising PET ligand for central NK(1) receptors. (2005) (3)
- [Non-sedative antihistaminics and binding to central and peripheral H1 histamine receptors]. (1991) (3)
- Effects of proteolytic enzymes and monovalent ions demonstrate protease-sensitive and protease-insensitive stereospecific binding sites on dopaminergic receptors in rat striatum. (1982) (3)
- First Evaluation of [ 11 C ] R 116301 as an In Vivo Tracer of NK 1 Receptors in Man (2009) (3)
- 6.2 Role and localization of serotonin-5HT2 receptors (1992) (2)
- Demonstration of a complex subunit composition of a unitary dopamine receptor: effects of lesions and proteolytic enzymes on stereospecific binding. (1983) (2)
- [11C]AF150(S): An agonist PET ligand for the M1 muscarinic acetylcholine receptor (2010) (2)
- A new metabolic pathway in the one-carbon transfer reaction. (1973) (2)
- 16-3 Neurotransmitter receptor profiles of antipsychotics, relations to clinical properties (1997) (2)
- Specificity of enzyme and methyl donor for methylation reactions. (1973) (2)
- Efficient expression of neurotransmitter receptors in mammalian cells: use of inducible expression systems. (1998) (2)
- Radiosynthesis, evaluation and preclinical studies of a new 5HT 2A radioligand (1998) (2)
- The tachykinin NK1 receptor antagonist, RP67580, inhibits the bradykinin-induced rise in intracellular Ca2+ concentration in bovine pulmonary artery endothelial cells. (1998) (2)
- P.3.053 Detection on 5HT7 receptors using [3H]risperidone: A brain regional distribution (1996) (2)
- RECEPTOR BINDING TECHNIQUES FOR STUDYING THE SELECTIVITY AND SITE OF ACTION OF PSYCHOTROPIC DRUGS (1984) (1)
- The pharmacological and biochemical basis of neuroleptic treatment in schizophrenia (1982) (1)
- Binding characterization of N‐(2‐chloro‐5‐thiomethylphenyl)‐N′‐(3‐[3H]3methoxy phenyl)‐N′‐methylguanidine ([3H]GMOM), a non‐competitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist (2019) (1)
- SEROTONIN RECEPTORS SITES: LOCALIZATION AND FUNCTION IN THE BRAIN AND PERIPHERAL TISSUES (1984) (1)
- Impact of Janssen drugs for the identification of brain receptors (1986) (1)
- The signal transducing system coupled to serotonin-S2 receptors (1988) (1)
- P.1.031: Localization of 5HT1Dα-and 5HT1Dβ-receptor mRNA by in situ hybridization in guinea pig brain and trigeminal ganglia (1996) (1)
- 3H-Ketanserin labels serotonin S2-receptor binding sites on cat blood platelets. (1983) (1)
- Radiosynthesis of a new radiobrominated ligand for 5HT2A receptors, a potential tracer for PET. (1997) (1)
- In vivo receptor occupancy by risperidone and ocaperidone in the rat brain, measured ex vivo by quantitative autoradiography (1991) (1)
- 3,4-Methylenedioxymethamphetamine (2020) (1)
- 499 5-HT2A receptor blockade in vivo in schizophrenic patients treated with atypical antipsychotics: Single photon emission tomography (SPET) findings (1997) (1)
- Initial evaluation of123|-5-|-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects (2006) (1)
- DIFFERENT NEUROLEPTIC RECEPTORS IN VARIOUS RAT BRAIN AREAS (1979) (1)
- Binding of GDNF and neurturin to human GDNF Family Receptor Alpha 1 and 2 (GFR aa 1-2); Influence of cRET and co-operative interactions (2000) (1)
- Excitatory Amino Acids and Their Antagonists (2015) (1)
- [11C]Af150(S), An Agonist Pet Ligand for in Vivo Imaging of the M1 Muscarinic Acetylcholine Receptor (2009) (1)
- Reduction of a distinct pool of monoamines by ketanserin in peripheral tissues (1990) (1)
- Seasonal variation in paroxetine binding to platelets in normal volunteers: relationships to climate factors (1996) (1)
- [11C]R129144 as a putative PET ligand for the adrenergic {alpha}2 receptor (2010) (0)
- Involvement of 5-HT2 (S2)- Receptor Sites in the Serotonin-Induced Activation of Cat Platelets (1984) (0)
- [Nursing approach of complications in intravenous therapy]. (1980) (0)
- [Characterization of serotonergic receptors]. (1988) (0)
- release fromratstriatum iscoupled toK+-channels. 2 Inthepresent study, an attempt was madetoelucidate further therole ofthese K+-channels, using theK+-channel blocking agentstetraethylammonium (1989) (0)
- Encoding (2021) (0)
- S.25.02 5HT1B and 5HT1D receptor subtypes, localisation studies, towards the untangling of their roles (1997) (0)
- β-Adrenergic Receptor Coupled Adenylate Cyclase Activity in Living Cardiac Cells (1991) (0)
- Isoform (2020) (0)
- LONG-TERM DESENSITIZATION OF DOPAMINE D2 RECEPTORS FOLLOWING INTERMITTENT MORPHINE TREATMENT (1995) (0)
- Antagonist-mediated potentiation of glutamate-induced intracellular calcium mobilization in mGluR1a expressing cells (1999) (0)
- Efficacy (2021) (0)
- Abstracts of papers and posters Meeting on Pharmaceutical Sciences (1993) (0)
- Muscarinic Cholinergic Receptor Agonists and Antagonists (2015) (0)
- Identity and properties of multiple neuroleptic-binding sites in rat limbic brain areas [proceedings]. (1979) (0)
- Molecular cloning an pharmacologiel analysis of neurotransmitter receptors from the central nervous sysem of Lymnaea stagnalis. (1995) (0)
- Kinetics of brain receptor binding inhibition by endogenous macromolecular substances [proceedings]. (1980) (0)
- Endogenous ligands for CNS drug receptors? (1978) (0)
- Evaluation of [C-11]R116301 as a PET tracer of the NK1 receptor: A test-retest study in human subjects (2007) (0)
- The importance of a disulphide bond in the binding of dopamine to the D2 receptor: A molecular modelling study (1993) (0)
- 39-47 Induction of neurotensin mRNA in rat brain after treatment with antipsychotic drugs: A predictive model for motor side effects? (1997) (0)
- SNP (2020) (0)
- P-4-34 Risperidone compared to novel and reference antipsychotic drugs for the in vivo occupancy of rat brain neurotransmitter receptors (1995) (0)
- Preclinical pharmacology of R121919, a CRFI receptor antagonist (2001) (0)
- Spectral map analysis of receptor amino acid sequences (1990) (0)
- Agonist-induced GTP & # 61543 ;[S-35] binding appears to be a more sensitive tool to assess group II/III mGluR expression as compared to adenylyl cyclase inhibition (1999) (0)
- Design, Structure-Activity, Labelling and Purity in the Development of Receptor Interacting Radiohalogenated Tracers (1995) (0)
- Epival (1997) (0)
- Effect of dopamine on plasma membrane phospholipid methylation of cultured anterior pituitary cells. (1982) (0)
- [Radiotherapy as primary treatment for chemodectoma?]. (1990) (0)
- Discovery of a Series of New Non-Indole 5HT1D Agonists (2010) (0)
- Further validation of in vivo and in vitro pharmacological procedures for assessing the alpha 2/alpha 1-selectivity of test compounds: (1). Alpha-adrenoceptor antagonists. (1986) (0)
- Cortical 5-HT release in vivo after repeated treatment with a 5-HT2 agonist and a thyrotrophin releasing hormone analogue (1990) (0)
- 5-HT2 agents in anxiety (1991) (0)
- RGS gene expression changes in the dopaminergic system by specific D1 and D2 agents: Clues for receptor selectivity of RGS proteins (2003) (0)
- S.18.03 5HT2 receptor subtypes: Central localisation, roles and possible therapeutic applications of agonists and antagonists (1996) (0)
- Radioligand binding profile of enantiomers of tifluadom analogues for opioid, CCK and central benzodiazepine receptors: Versatility of the benzodiazepine skeleton (1994) (0)
- High-level expression of neurotransmitter receptors: Comparison of the usefulness of four different inducible expression systems (2000) (0)
- P.1.g.069 Aberrant ligand–receptor dynamics of the muscarine-M1 agonist AF150(S) (2013) (0)
- Kinetic investigation of [3H] spiperone-binding sites in rat frontal cortex [proceedings]. (1978) (0)
- Serotonin Receptor Binding Sites: Localization and Role in the Brain and Peripheral Tissues (1984) (0)
- Heterologous Expression of G Protein-Coupled Receptors in Yeasts: an Approach to Facilitate Drug Discovery (1997) (0)
- Differentiation between Stereospecific Binding Sites on a Dopamine Receptor Complex: Effects of Proteolytic Enzymes (1982) (0)
- Differential binding properties of drugs for interactions with sub-unit sites of the rat striatal dopaminergic receptor. (1982) (0)
- New dopamine- and serotonin receptor subtypes, targets for antipsychotics drugs in vivo? (1996) (0)
- IN VIVO RECEPTOR OCCUPANCY OF ANTIPSYCHOTICS: RELATION TO BEHAVIOURAL EFFECTS (1998) (0)
- 7th Internation Symposium on the synthesis and application of isotopes and isotopically labelledcompounds Development of a new 5HT2a receptor tracer for SPECT, its clinical and Pharmacoclinical application in neuropsychiatry. (2000) (0)
- Repetitive Behavior (2021) (0)
- Radiosynthesis of a Histamine H3 receptor antagonist: In vitro and in vivo evaluation (2006) (0)
- [ICD]. (2022) (0)
- MODULATION OF REGULATORS OF G-PROTEIN SIGNALLING MRNA EXPRESSION BY DOPAMINERGIC DRUGS (2000) (0)
- Overactivation of NMDA receptors in the aged APPswe-PS1dE9 brain, a mouse model of Alzheimer's disease (2012) (0)
- Detailed localization of RGS2 messenger RNA and protein in the rat brain Clues for function (2001) (0)
- Separated (2020) (0)
- Evaluation of [C-11]R116301 as a tracer for the in vivo measurement of NK1 receptors in human subjects (2005) (0)
- P.2.016 Investigation of the selectivity of vesamicol analogues as markers for cholinergic neurons: Potential ligands for single photon emission computerized tomography (SPECT) in Alzherimer's disease (1996) (0)
- Interaction of des-tyrosine-gamma-endorphin (DTgammaE, beta-LPH62-77) with neuroleptic binding sites in various areas of rat brain. (1978) (0)
- BRIEF ARTICLE First Evaluation of ( 11 C)R116301 as an In Vivo Tracer of NK1 Receptors in Man (2009) (0)
- P.1.e.026 [11C]AF150(S): a putative agonist PET ligand for in vivo imaging of the M1 muscarinic acetylcholine receptor (2010) (0)
- Radiosynthesis of [11C]R116301: A potential pet ligand for central NK1 receptors (2001) (0)
- Autoradiographic measurement of 5-HT2 and 5-HT1C receptors in rat brain after chronic treatment with ritanserin and DOM [Poster] (1990) (0)
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