J. Evan Sadler
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Why Is J. Evan Sadler Influential?
(Suggest an Edit or Addition)According to Wikipedia, Jasper Evan Sadler III was an American hematologist. Sadler was born in Huntington, West Virginia, on 9 November 1951 to pathologist Jasper Evan Sadler Jr. and his wife Clara Rose Thompson Sadler. The younger Sadler studied chemistry at Princeton University and completed a medical degree at Duke University School of Medicine. Sadler completed his residency at Duke and a fellowship at the University of Washington and subsequently joined Washington University School of Medicine faculty in 1984. Between 1982 and 2008, Sadler was a Howard Hughes Medical Investigator. In 2014, Sadler was appointed Ira M. Lang Professor of Medicine.
J. Evan Sadler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biochemistry and genetics of von Willebrand factor. (1998) (1347)
- Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor (2006) (1060)
- Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura* (2001) (797)
- von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) 1 (2008) (705)
- A Revised Classification of von Willebrand Disease (1994) (647)
- von Willebrand factor. (1991) (527)
- Impact, Diagnosis and Treatment of von Willebrand Disease (2000) (497)
- Structure of the gene for human von Willebrand factor. (1989) (489)
- Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. (1991) (459)
- Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura. (2004) (449)
- Amino acid sequence of human von Willebrand factor. (1986) (446)
- The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. (1994) (430)
- Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. (2008) (357)
- Recent advances in thrombotic thrombocytopenic purpura. (2004) (334)
- Von Willebrand disease type 1: a diagnosis in search of a disease. (2003) (312)
- Induction of specific storage organelles by von Willebrand factor propolypeptide (1991) (268)
- Cloning and characterization of two cDNAs coding for human von Willebrand factor. (1985) (264)
- Functional architecture of Weibel-Palade bodies. (2011) (253)
- Regulation of endothelial cell coagulant properties. Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor. (1989) (245)
- Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction. (1991) (241)
- Human tissue factor: cDNA sequence and chromosome localization of the gene. (1987) (192)
- New concepts in von Willebrand disease. (2005) (192)
- Pathogenesis of thrombotic microangiopathies. (2008) (191)
- cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta. (1987) (190)
- Cleavage of von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13* (2003) (186)
- cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms. (1986) (184)
- Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. (1987) (182)
- Molecular mapping of the heparin-binding exosite of thrombin. (1994) (177)
- von Willebrand factor: two sides of a coin (2005) (177)
- Thrombomodulin Structure and Function (1997) (176)
- Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress. (2008) (171)
- Assembly of Weibel–Palade body-like tubules from N-terminal domains of von Willebrand factor (2008) (167)
- Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13. (2004) (166)
- Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. (1994) (162)
- Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice. (1998) (161)
- Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms. (1991) (159)
- Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships. (1981) (154)
- Gene deletions correlate with the development of alloantibodies in von Willebrand disease. (1987) (151)
- Family studies and prenatal diagnosis in severe von Willebrand disease by polymerase chain reaction amplification of a variable number tandem repeat region of the von Willebrand factor gene. (1990) (150)
- Remission of Chronic Thrombotic Thrombocytopenic Purpura after Treatment with Cyclophosphamide and Rituximab (2003) (144)
- Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor. (1996) (137)
- Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. (2009) (136)
- Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum. (1993) (132)
- Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands. (1979) (129)
- Restoration of specific myxovirus receptors to asialoerythrocytes by incorporation of sialic acid with pure sialyltransferases. (1979) (128)
- Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor (2005) (127)
- Identification of Amino Acid Residues Essential for von Willebrand Factor Binding to Platelet Glycoprotein Ib. (1995) (127)
- Biosynthesis of mammalian glycoproteins. Glycosylation pathways in the synthesis of the nonreducing terminal sequences. (1979) (125)
- Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease (2006) (123)
- Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity* (2003) (122)
- von Willebrand factor assembly and secretion (2009) (122)
- Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor* (2000) (121)
- Binding of ADAMTS13 to von Willebrand Factor* (2005) (117)
- Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin. (1991) (108)
- Interaction of von Willebrand factor domain A1 with platelet glycoprotein Ibalpha-(1-289). Slow intrinsic binding kinetics mediate rapid platelet adhesion. (2000) (108)
- Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences. (1991) (107)
- Pathophysiology of thrombotic thrombocytopenic purpura. (2017) (104)
- Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland. (1979) (103)
- Clinical and laboratory diagnosis of von Willebrand disease: A synopsis of the 2008 NHLBI/NIH guidelines (2009) (103)
- Low von Willebrand factor: sometimes a risk factor and sometimes a disease. (2009) (102)
- Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity. (2008) (102)
- Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin. (1989) (98)
- Allosteric activation of ADAMTS13 by von Willebrand factor (2014) (96)
- von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib. (1992) (95)
- Mammalian protein secretion without signal peptide removal. Biosynthesis of plasminogen activator inhibitor-2 in U-937 cells. (1988) (94)
- Multi‐step binding of ADAMTS‐13 to von Willebrand factor (2009) (93)
- Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity. (1992) (92)
- Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide. (1999) (90)
- Bovine Proenteropeptidase Is Activated by Trypsin, and the Specificity of Enteropeptidase Depends on the Heavy Chain* (1997) (89)
- Molecular Mechanism and Classification of von Willebrand Disease (1995) (89)
- Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins. (2001) (89)
- The role of sialic acid in the expression of human MN blood group antigens. (1979) (88)
- Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C* (1998) (88)
- Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. (1998) (86)
- Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow. (2005) (85)
- Commentary: a new classification for von Willebrand disease. (1994) (82)
- Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. (2002) (81)
- Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice. (2010) (81)
- Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi (2007) (80)
- What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura. (2015) (80)
- Zinc and Calcium Ions Cooperatively Modulate ADAMTS13 Activity* (2006) (79)
- Disulfide bonds required to assemble functional von Willebrand factor multimers. (1994) (79)
- Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3. (1989) (78)
- Expression of von Willebrand factor "Normandy": an autosomal mutation that mimics hemophilia A. (1991) (78)
- Localization of von Willebrand Factor-binding Sites for Platelet Glycoprotein Ib and Botrocetin by Charged-to-Alanine Scanning Mutagenesis* (2000) (78)
- A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. (2009) (78)
- Crystal Structure of von Willebrand Factor A1 Domain Complexed with Snake Venom, Bitiscetin (2003) (77)
- ADAMTS13 and TTP (2002) (76)
- Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project. (2007) (75)
- Medicine: K is for koagulation (2004) (75)
- Severe type III von Willebrand's disease caused by deletion of exon 42 of the von Willebrand factor gene: family studies that identify carriers of the condition and a compound heterozygous individual. (1990) (75)
- Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues. (1990) (73)
- Localization of the single-stranded DNA binding site in the thrombin anion-binding exosite. (1992) (73)
- Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans. (1994) (71)
- Platelets: thrombotic thrombocytopenic purpura. (2002) (70)
- Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands. (1979) (70)
- Crystal structure of the human α‐thrombin–haemadin complex: an exosite II‐binding inhibitor (2000) (68)
- The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. (1988) (68)
- Platelet Glycoprotein Ibα Binds to Thrombin Anion-binding Exosite II Inducing Allosteric Changes in the Activity of Thrombin* (2001) (66)
- cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen. (1995) (65)
- Structure-function relationships of the thrombin-thrombomodulin interaction. (1993) (63)
- Apical Sorting of Bovine Enteropeptidase Does Not Involve Detergent-resistant Association with Sphingolipid-Cholesterol Rafts* (1999) (62)
- A Covalent Oxidoreductase Intermediate in Propeptide-dependent von Willebrand Factor Multimerization* (2004) (61)
- [41] Purification of mammalian glycosyltransferases (1982) (60)
- Unfolding the A2 domain of von Willebrand factor with the optical trap. (2010) (60)
- A new name in thrombosis, ADAMTS13 (2002) (58)
- Slippery criteria for von Willebrand disease type 1 (2004) (57)
- Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. (1980) (56)
- Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin. (1994) (55)
- Enteropeptidase, a type II transmembrane serine protease. (2009) (55)
- Activation-induced exposure of the thrombin anion-binding exosite. Interactions of recombinant mutant prothrombins with thrombomodulin and a thrombin exosite-specific antibody. (1994) (54)
- Thrombotic thrombocytopenic purpura: a moving target. (2006) (53)
- A Standard Nomenclature for von Willebrand Factor Gene Mutations and Polymorphisms (2001) (53)
- Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity. (1993) (53)
- Mechanism by which heparin proteoglycan modulates mast cell chymase activity. (1999) (51)
- Regulation of human tissue factor expression by mRNA turnover. (1993) (51)
- Contact--How Platelets Touch von Willebrand Factor (2002) (50)
- Aortic stenosis, von Willebrand factor, and bleeding. (2003) (49)
- Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer (2016) (48)
- Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS‐13 (2015) (48)
- Activation of recombinant proenteropeptidase by duodenase (2000) (44)
- The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor. (1992) (43)
- Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways. (2011) (40)
- Expression of human soluble tissue factor in yeast and enzymatic properties of its complex with factor VIIa. (1992) (38)
- Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin. (1992) (38)
- Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development. (1998) (37)
- Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis. (2013) (34)
- Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib. (1993) (33)
- A Database of Polymorphisms in the von Willebrand Factor Gene and Pseudogene (1993) (32)
- Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases* (2012) (31)
- Identification of the Regulatory Elements of the Human von Willebrand Factor for Binding to Platelet GPIb (2002) (31)
- Crystal structure of von Willebrand Factor A1 domain complexed with snake venom bitiscetin (2003) (30)
- Phylogenetic and Functional Analysis of Histidine Residues Essential for pH-dependent Multimerization of von Willebrand Factor*♦ (2011) (30)
- Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin. (1993) (30)
- An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura (2013) (29)
- Type 2M von Willebrand Disease: F606I and I662F Mutations in the Glycoprotein Ib Binding Domain Selectively Impair Ristocetin- but not Botrocetin-Mediated Binding of von Willebrand Factor to Platelets (1998) (29)
- Evolution of human von Willebrand factor: cDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II. (1987) (28)
- New variant of von Willebrand disease type II with markedly increased levels of von Willebrand factor antigen and dominant mode of inheritance: von Willebrand disease type IIC Miami. (1993) (27)
- SYNTHETIC RGD-CONTAINING PEPTIDES OF VON WILLEBRAND FACTOR INHIBIT PLATELET ADHESION TO COLLAGEN (1987) (27)
- Mucin-like Domain of Enteropeptidase Directs Apical Targeting in Madin-Darby Canine Kidney Cells* (2002) (27)
- Biomedicine. Contact--how platelets touch von Willebrand factor. (2002) (27)
- Adjuvant low-dose rituximab and plasma exchange for acquired TTP. (2019) (26)
- Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2. Evidence for independent regulation. (1989) (25)
- Effect of Type IIB von Willebrand Disease Mutation Arg(545)Cys on Platelet Glycoprotein Ib Binding – Studies with Recombinant von Willebrand Factor (1993) (24)
- THE MOLECULAR BIOLOGY OF VON WILLEBRAND FACTOR (1991) (24)
- Accelerated clearance alone explains ultra‐large multimers in von Willebrand disease Vicenza (2010) (22)
- Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity. (2000) (22)
- Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. (2002) (21)
- Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation. (2019) (21)
- A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury. (2004) (19)
- Analysis of Arg834Gln and Val902Glu type 2A von Willebrand disease mutations: studies with recombinant von Willebrand factor and correlation with patient characteristics. (1996) (19)
- Cloning of cDNA and genomic DNA for human von Willebrand factor. (1986) (19)
- Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289) (2000) (17)
- von Willebrand factor in its native environment. (2013) (17)
- Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering. (2019) (17)
- Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen. (1984) (17)
- Characterization of Three Mutations Causing von Willebrand Disease Type IIA in Five Unrelated Families (1992) (16)
- Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor. (2006) (14)
- Structural biology. A ménage à trois in two configurations. (2003) (14)
- Refractory immune hemolytic anemia with a high thermal amplitude, low affinity IgG anti-Pra cold autoantibody. (1992) (13)
- von Willebrand's factor and von Willebrand's disease. (1994) (12)
- The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner. (2012) (12)
- Affinity chromatography of glycosyltransferases. (1981) (12)
- Regional localization of the human thrombomodulin gene to 20p12-cen. (1989) (12)
- Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method (1993) (12)
- Weibel-Palade bodies. (2011) (11)
- Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis (2008) (11)
- Purification of mammalian glycosyltransferases. (1982) (9)
- The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding (2016) (9)
- Ligand specificity of human thrombomodulin. Equilibrium binding of human thrombin, meizothrombin, and factor Xa to recombinant thrombomodulin. (1992) (9)
- Proteomics, genomics and the future of medical education. (2004) (9)
- A new name in thrombosis, I (2016) (8)
- Redeeming ristocetin. (2010) (8)
- Should all adult patients with diarrhoea-associated HUS receive plasma exchange? (2012) (8)
- Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami (2016) (7)
- von Willebrand disease type B: A missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein lb (7)
- Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method. (1993) (6)
- Identification and mapping of RFLPs for human tissue factor (HTF) to chromosome 1p. (1987) (6)
- Increased Clearance Explains the Ultra-Large Multimers in Von Willebrand Disease Type 2M Vicenza; Lessons from Recombinant VWF Vicenza and Modeling of Multimer Catabolism. (2004) (6)
- Report on the workshop: Von Willebrand factor and thrombotic thrombocytopenic purpura (2001) (5)
- Very Low Frequency of “Normandy Type” Mutations among Type 1 von Willebrand Disease Families (1995) (5)
- Race, Rituximab, and Relapse in TTP. (2022) (5)
- Interesting variations on how a disease is defined: comparisons of von Willebrand disease and Glanzmann thrombasthenia. Reply to a rebuttal (2007) (4)
- Characterization of the Binding Interaction between ADAMTS13 and von Willebrand Factor (VWF). (2004) (4)
- Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma. (2007) (4)
- Appendix II: A revised classification of Von Willebrand disease * (1997) (4)
- Efficacy of Adjuvant Low Dose Rituximab and Plasma Exchange for Acquired TTP with Severe ADAMTS13 Deficiency — Results of the ART Study (2018) (4)
- Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development. (1998) (3)
- Purification and Characterization of Two Sialyltransferase Activities from Porcine Submaxillary Glands (1979) (3)
- Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations (2019) (3)
- Molecular Basis of von Willebrand Disease Type (2013) (3)
- under fluid shear stress (2013) (3)
- Morphological and Functional Studies of Ultra Long Von Willebrand Factor (ULVWF) Anchored on Endothelial Surface. (2006) (2)
- Recombinant DNA methods in hemophilia A: carrier detection and prenatal diagnosis. (1990) (2)
- Atypical HUS may become a diagnosis of inclusion. (2015) (2)
- Single Particle Tracking of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type-1 Repeats) Molecules on Endothelial von Willebrand Factor Strings* (2014) (1)
- VWD data worth 10 000 words (2007) (1)
- Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with Aptamer ARC1172, An Inhibitor of VWF-Platelet Binding (2009) (1)
- An Optimized Fluorogenic Assay with Increased Sensitivity for ADAMTS13 Activity and Inhibitors for the Characterization of Patients with Thrombotic Thrombocytopenic Purpura (2011) (1)
- Abstract 481: Characteristics of Two Thrombotic Thrombocytopenic Purpura (TTP) Syndromes Associated with Ticlopidine and Clopidogrel: Results From the Surveillance, Epidemiology, and Risk Factors for Thrombotic Thrombocytopenic Purpura (SERF-TTP) Research Group (2006) (1)
- Binding of ADAMTS13 to Von Willebrand Factor Under Static Conditions and Under Fluid Shear Stress (2008) (1)
- Abstract 306: The Atherogenic Metalloprotease ADAMTS7 Secretion Requires Propeptide and Substrate Screening Suggests Broad Specificity (2019) (1)
- The functions of the A 1 A 2 A 3 domains in von Willebrand factor include multimerin 1 binding SHORTENED TITLE ( 50 Characters ) : VWF A 1 A 2 A 3 domains support MMRN 1 binding (2016) (1)
- A Folded ADAMTS13 Conformation Identified By Small-Angle X-Ray Scattering Can Account for Allosteric Regulation By Distal Thrombospondin-1 and CUB Domains (2014) (1)
- The Involvement of Copper Transport in Von Willebrand Factor Multimer Assembly (2016) (0)
- Integrin (cid:1) v (cid:2) 3 on human endothelial cells binds von Willebrand factor strings under fluid shear stress (2009) (0)
- Assembly, Storage, and Secretion of Von Willebrand Factor. (2008) (0)
- Faculty Opinions recommendation of Shear-induced unfolding triggers adhesion of von Willebrand factor fibers. (2007) (0)
- Von Willebrand factor , ADAMTS 13 , and thrombotic thrombocytopenic purpura (2008) (0)
- QQHPEYM ENMICAGYEE GGIDSCQGDS PICLPEENQV FPPGRICSIA GWGALIY . QG STADVLQEAD VPLLSNEKCQ . QQMPEYEW ENMVCAGYEA GGVDSCQGDS PICLPSKGDR NVIYTDCWVT GWGYRKL . RD KIQNTLQKAK IPLVTNEECQ . KRYRGHKIT HKMICAGYRE GGKDACKGDS PVCLPAAGQA LVDGKICTVT GWGNTQY . YG QQAGVLQEAR VPIISNDVCN GADFYGNQIK PKMFCAGYPE GGIDACQGDS (0)
- A Descriptive Analysis of the Demographics and Presenting Symptoms of Patients in the U.S. Thrombotic Microangiopathy (USTMA) TTP Registry (2017) (0)
- Research Funding 2012 - The New Normal is Getting Old (2011) (0)
- dominant mutations of oligomeric proteins retention and degradation of heterodimers: a possible general mechanism for Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular (2013) (0)
- Characterization of the Binding Between the Polymeric Platelet Adhesive Proteins, Multimerin 1 and Von Willebrand Factor (2011) (0)
- A broader look at thrombotic microangiopathy and ADAMTS13 (2003) (0)
- Phospholipase D1 Is Required for Regulated Secretion of VWF Induced by the B-Subunits of Shiga-Like Toxins 1 and 2 (2010) (0)
- The flexible tail of the hemostatic enzyme ADAMTS13 is able to shield the active site (2014) (0)
- Willebrand factor by abolishing binding to factor VIII. Studies with recombinant von The mutation Arg (53)----Trp causes von Willebrand disease Normandy (2011) (0)
- Small-Angle X-Ray Scattering Studies of ADAMTS13 Demonstrate a Conformational Response to Substrate Binding in Solution (2011) (0)
- Shiga Toxin 1(Stx1) Stimulates Endothelial Cell VWF Secretion through a Ca2+/PKC Signaling Pathway That Does Not Require the Active Toxin Stx1A Subunit (2008) (0)
- R268A, inhibits thrombosis in a model of acute carotid artery injury A recombinant murine meizothrombin precursor, prothrombin R157A/ (2013) (0)
- Thrombotic thrombocytopenic purpura (2015) (0)
- fluid shear stress Platelet-VWF complexes are preferred substrates of ADAMTS13 under (2013) (0)
- Response: Diagnosing VWD type 1: when is it useful and when illogical? (2007) (0)
- von Willebrand factor content in Alphanate® (Laurence J. Logan) – reply (2009) (0)
- The C-Terminal α-Helix of von Willebrand Factor Domain A2 Interacts with ADAMTS13 C-Terminal Domains To Regulate Substrate Cleavage. (2005) (0)
- President’s Column: Restoring Clinical and Translational Research (2011) (0)
- THE SERINE PROTEASE DOMAIN OF ENTEROPEPTIDASE BOUND TO INHIBITOR VAL-ASP-ASP-ASP-ASP-LYS-CHLOROMETHANE (1999) (0)
- The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering (2016) (0)
- ADAMTS13: von Willebrand factor-cleaving protease (2004) (0)
- Isolation and characterization of glycosyl transferases. (1977) (0)
- Synthetic RGDS-Containing Peptides of von Willebrand Factor Inhibit Platelet Adhesion to Collagen (1990) (0)
- Catalyzing Careers in Clinical Hematology Research (2011) (0)
- Integrin αvβ3 Is Involved in the Stabilization of Ultra Long von Willebrand Factor Strings under Fluid Shear Stress on Human Endothelial Cells. (2007) (0)
- shear stress Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid (2013) (0)
- Two-Hybrid Screening Identifies an Interaction between the CUB Domains of Human ADAMTS13 and Factor XII. (2007) (0)
- B Subunits of Shiga Toxin 2 Induce VWF Secretion by a cAMP-Independent Protein Kinase A Signaling Pathway. (2009) (0)
- Reversible Self-Assembly of Weibel-Palade Body-Like Tubules from Recombinant N-Terminal Domains of von Willebrand Factor. (2007) (0)
- Tea for Whom? — ASH and the New Congress (2011) (0)
- Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation (2016) (0)
- Scientific Report of the Registry on Acquired von Willebrand Syndrome : Recommendations for Diagnosis and Management (2000) (0)
- Contacts between Several ADAMTS13 Structural Domains and von Willebrand Factor Domain A2 Contribute to Substrate Cleavage. (2007) (0)
- Phillip W. Majerus, MD (1936-2016) (2016) (0)
- Professional Society Membership and Career Development - Join Early (2011) (0)
- Distinct Functions of pH-Sensing Histidine Residues in the Multimer Assembly and Storage of Von Willebrand Factor in Weibel-Palade Bodies (2012) (0)
- Boosting a natural anticoagulant (2001) (0)
- Chapter 586 – Enteropeptidase (2013) (0)
- hematopoiesis , umbilical Cord Blood , health-Care reform , and mosquitoes : ash 2010 (0)
- fluid shear stress Platelet-VWF complexes are preferred substrates of ADAMTS 13 under (2007) (0)
- Glycosylation Pathways in Glycoprotein Biosynthesis (2002) (0)
- Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor (2011) (0)
- Non-Catalytic Domains of ADAMTS13 Can Redirect the Substrate Specificity of ADAMTS5 (2010) (0)
- A C-Terminal Exosite of von Willebrand Factor Domain A2 Interacts with ADAMTS13 Spacer Domain To Accelerate Substrate Cleavage. (2006) (0)
- Structure and localization of the thrombin receptor gene on mouse Chromosome 13 (1996) (0)
- GLYCOSYL TRANSFERASES IN OLIGOSACCHARIDE BIOSYNTHESIS AND THEIR USE IN STRUCTURE - FUNCTION ANALYSIS OF GLYCOPROTEINS (1980) (0)
- African American Race Is Associated with Decreased Relapse-Free Survival in Immune Thrombotic Thrombocytopenic Purpura (2019) (0)
- Identification of Cysteine Residues Essential for von Willebrand Factor (VWF) Multimerization. (2006) (0)
- President's Column: ASH Highlights Continual Commitment to Basic Hematology Research by Establishing a New Committee on Scientific Affairs (2011) (0)
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