John Hyttel
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(Suggest an Edit or Addition)John Hyttel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- SCH 23390 - the first selective dopamine D-1 antagonist. (1983) (734)
- Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity (1982) (588)
- Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs) (1994) (479)
- Comparison of the Effects of Antidepressants and Their Metabolites on Reuptake of Biogenic Amines and on Receptor Binding (1999) (400)
- Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics. (1984) (380)
- Dopamine D-1 receptor agonists combined with the selective D-2 agonist quinpirole facilitate the expression of oral stereotyped behaviour in rats. (1987) (257)
- Effects of neuroleptics on 3H-haloperidol and 3H-cis(Z)-flupenthixol binding and on adenylate cyclase activity in vitro. (1978) (246)
- The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer (2005) (237)
- Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions. (1984) (162)
- Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. (1992) (150)
- Receptor-binding profiles of neuroleptics. (1985) (131)
- Functional evidence for selective dopamine D-1 receptor blockade by SCH 23390 (1984) (131)
- Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. (1988) (127)
- Facilitation of 8-OHDPAT-induced forepaw treading of rats by the 5-HT2 agonist DOI. (1989) (123)
- The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice (2005) (112)
- 3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. (1985) (109)
- Neurochemical and in vivo pharmacological profile of sertindole, a limbic‐selective neuroleptic compound (1991) (107)
- Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors. (1994) (102)
- Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro. (1981) (98)
- A comparison of the effect of neuroleptic drugs on the binding of 3H-haloperidol and 3H-cis(Z)-flupenthixol and on adenylate cyclase activity in rat striatal tissue in vitro (1978) (85)
- Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171 (1977) (78)
- Serotonin-selective antidepressants. (2009) (73)
- Ontogeny of Dopamine D1 Receptors in Rat Striatum (1986) (73)
- Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. (1992) (73)
- Inhibition of [3H]dopamine accumulation in rat striatal synaptosomes by psychotropic drugs. (1978) (71)
- Comparative pharmacology of selective serotonin re-uptake inhibitors (SSRIs) (1993) (69)
- The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters. (2009) (69)
- Inactivation of dopamine D-1 or D-2 receptors differentially inhibits stereotypies induced by dopamine agonists in rats. (1988) (68)
- Age related decrease in the density of dopamine D1 and D2 receptors in corpus striatum of rats. (1987) (67)
- Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram (2004) (66)
- Distinct target size of dopamine D-1 and D-2 receptors in rat striatum. (1984) (57)
- Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: effect on dopaminergic and serotonergic functions. (1984) (53)
- Kainate lesion dissociates striatal dopamine receptor radioligand binding sites. (1981) (52)
- Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats (2004) (50)
- Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. (1996) (46)
- The acute effect of sertindole on brain 5-HT2, D2 and α1 receptors (ex vivo radioreceptor binding studies) (2005) (45)
- Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers (2004) (44)
- Neuropharmacological properties of amitriptyline, nortriptyline and their metabolites. (2009) (40)
- Effects of putative dopamine autoreceptor agonists in pharmacological models related to dopaminergic and neuroleptic activity. (1982) (38)
- Enhanced D1 affinity in a series of piperazine ring substituted 1-piperazino-3-arylindans with potential atypical antipsychotic activity. (1995) (35)
- Characterization of dopamine D-1 and D-2 receptors. (1986) (34)
- Differentiation of classical and novel antipsychotics using animal models (1997) (34)
- Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. (1988) (33)
- PHARMACOLOGICAL PROFILE OF THE ATYPICAL NEUROLEPTIC SERTINDOLE (1992) (32)
- Effect of neuroleptics on the disappearance rate of [14C] labelled catecholamines formed from [14C]tyrosine in mouse brain (1974) (31)
- Further studies of the mechanism behind scopolamine-induced reversal of antistereotypic and cataleptogenic effects of neuroleptics in rats. (2009) (31)
- Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro (1978) (31)
- Differential reversal by scopolamine of effects of neuroleptics in rats. Relevance for evaluation of therapeutic and extrapyramidal side-effect potential. (1981) (28)
- EEDQ, a tool for ex vivo measurement of occupancy of D-1 and D-2 dopamine receptors. (1988) (27)
- Citalopram An introduction (1982) (27)
- Levels of HVA and DOPAC in mouse corpus striatum in the supersensitivity phase after neuroleptic treatment (1977) (27)
- Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model. (1990) (26)
- Biochemical and pharmacological differentiation of neuroleptic effect on dopamine D-1 and D-2 receptors. (1983) (25)
- Changes in catecholamine concentrations and synthesis rate in mouse brain during the ‘supersensitivity’ phase after treatment with neuroleptic drugs (1976) (24)
- Behavioural correlates to the dopamine D-1 and D-2 antagonists. (1984) (24)
- Effect of prolonged treatment with neuroleptics on dopamine D-1 and D-2 receptor density in corpus striatum of mice. (2009) (23)
- Pharmacology in vivo of the phenylindan derivative, lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain (1985) (22)
- Pharmacological in vitro characterization of the arecoline bioisostere, Lu 25‐109‐T, a muscarinic compound with M1‐agonistic and M2/M3‐antagonistic properties (1997) (22)
- Effect of a selective 5-HT uptake inhibitor--Lu 10-171--on rat brain 5-HT turnover. (2009) (22)
- Central 5-HTP decarboxylase inhibiting properties of Ro 4-4602 in relation to 5-HTP potentiation in mice. (1972) (22)
- Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists. (1991) (22)
- 5-HT-uptake inhibition potentiates antinociception induced by morphine, pethidine, methadone and ketobemidone in rats. (1985) (21)
- LONG‐TERM EFFECTS OF TEFLUTIXOL ON THE SYNTHESIS AND ENDOGENOUS LEVELS OF MOUSE BRAIN CATECHOLAMINES (1975) (21)
- Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats (2005) (20)
- Parallel decrease in the density of dopamine D1 and D2 receptors in corpus striatum of rats from 3 to 25 months of age. (1989) (19)
- Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles. (1992) (18)
- Characterization of binding of3H-SCH 23390 to dopamine D-1 receptors. Correlation to other D-1 and D-2 measures and effect of selective lesions (2005) (18)
- Selective dopamine D1 and D2 receptor antagonists. (1989) (18)
- Behavioral differentiation between effects elicited at dopamine D-1 and D-2 receptors in rats with normosensitive DA receptors. (1988) (18)
- The dopamine D-1 antagonist SCH 23390 inhibits apomorphine but not pergolide induced rotation. (1984) (17)
- Neuroleptic classification: implications for tardive dyskinesia. (1983) (16)
- Studies on lysosome stabilization by antirheumatic drugs. (1970) (16)
- The St 587-induced flexor reflex in pithed rats: a model to evaluate central alpha 1-receptor blocking properties. (1986) (15)
- Interaction of the antiemetic metopimazine and anticancer agents with brain dopamine D2, 5-hydroxytryptamine3, histamine H1, muscarine cholinergic and α1 receptors (2004) (15)
- Further evidence that 3H-cis(Z)flupenthixol binds to the adenylate cyclase-associated dopamine receptor (D-1) in rat corpus striatum (2004) (14)
- Neurochemical profile in vitro of irindalone: A5‐HT2‐receptor antagonist (1988) (14)
- Changes in rat dopamine- and serotonin function in vivo after prolonged administration of the specific 5-HT uptake inhibitor, citalopram (2004) (13)
- Selective inactivation of dopamine D1 and D2 receptors in 6-hydroxydopamine-lesioned rats: evidence that the effect of D1 and D2 agonists can be expressed in the absence of the heterologous DA receptor. (1989) (13)
- NEUROCHEMICAL PARAMETERS IN THE HYPERRESPONSIVE PHASE AFTER A SINGLE DOSE OF NEUROLEPTICS TO MICE (1979) (13)
- Changes in dopamine synthesis rate in the supersensitivity phase after treatment with a single dose of neuroleptics (1977) (12)
- Dopamine D-2 agonists with high and low efficacies: differentiation by behavioural techniques (2005) (12)
- The pharmacology of a new potent, long acting neuroleptic, piflutixol. (2009) (12)
- Peripheral and central muscarinic receptor affinity of psychotropic drugs (1977) (11)
- In vivo pharmacology of irindalone, a 5‐HT2 receptor antagonist with predominant peripheral effects (1989) (11)
- Effects of a single administration of clozapine on mouse brain catecholamines. (2009) (10)
- Behavioural differentiation between effects elicited at dopamine D-1 and D-2 receptors in rats. (1986) (10)
- Adaptational phenomena in neuroleptic treatment. (1978) (9)
- Dopamine-receptor binding and adenylate-cyclase activity in mouse striatal tissue in the supersensitivity phase after neuroleptic treatment (1978) (8)
- Inhibition of SKF 38393- and pergolide-induced circling in rats with unilateral 6-OHDA lesion is correlated to dopamine D-1 and D-2 receptor affinitiesin vitro (2005) (8)
- Serotonin uptake inhibitors (2017) (8)
- Effects of S (+)-3-phenethyl-PP, a putative dopamine autoreceptors agonist with greater autoreceptor selectivity than 3-PPP enantiomers. (1984) (7)
- Interaction of the antiemetic metopimazine and anticancer agents with brain dopamine D2, 5-hydroxytryptamine3, histamine H1, muscarine cholinergic and alpha 1-adrenergic receptors. (1993) (7)
- Target size of dopamine D-1 receptors in rat corpus striatum estimated by binding of the benzazepine 3H-SCH 23390. (1987) (6)
- L-5-HTP facilitates the electrically stimulated flexor reflex in pithed rats: evidence for 5-HT2-receptor mediation. (1990) (6)
- Effect of a dopamine D-1 agonist in rats treated chronically with zuclopenthixol. (1990) (6)
- DO DOPAMINE D-1 RECEPTORS CONTRIBUTE TO THE ANTIPSYCHOTIC EFFECTS AND SIDE EFFECTS OF NEUROLEPTIC DRUGS? (1984) (6)
- Dopamine D-1 and D-2 Receptor Differentiation Revealed by Behavioural Studies in Rats (1988) (5)
- Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans. (1993) (5)
- Effect of piflutixol on turnover of catecholamines in mouse brain and rat corpus striatum. (2009) (5)
- Pharmacological characterization of Lu 25-109-T, a compound with M 1 agonistic and M 2 M 3 - antagonistic effects on muscarinic receptors (1995) (5)
- Down-regulation of dopamine D-2, 5-HT2 receptors and β-adrenoceptors in rat brain after prolonged treatment with a new potential antidepressant, Lu 19-005 (2005) (4)
- Flupentixol and dopamine receptor selectivity (2004) (4)
- Endogenous levels and turnover of catecholamines in mouse brain after repeated administration of haloperidol (1974) (4)
- No evidence for increased dopamine receptor binding in superresponsive mice after a single dose of neuroleptics. (1980) (2)
- [Receptor-blockade and receptor-hypersensitivity following neuroleptic treatment (author's transl)]. (1976) (2)
- Characterization of 3H-GABA receptor binding to rat brain synaptosomal membranes: Effect of non GABAergic compounds (1979) (2)
- Enhanced D1 Affinity in a Series of Piperazine Ring Substituted 1‐ Piperazino‐3‐arylindans with Potential Atypical Antipsychotic Activity. (1996) (2)
- TARDIVE DYSKINESIA AND DOPAMINE RECEPTORS (1979) (2)
- Sertindole - a novel atypical neuroleptic drug (1993) (0)
- O-13-3 Differentiation of classical and novel antipsychotics using animal models (1996) (0)
- 3-Phenyl-1-indanamines. Potential Antidepressant Activity and Potent Inhibition of Dopamine, Norepinephrine and Serotonin Uptake. (1986) (0)
- Inhibition of cholera toxin-induced secretion by neuroleptics. (1984) (0)
- Receptor pharmacology. Its use in neuroleptic research. (1987) (0)
- Effect of chronic neuroleptic treatment on spontaneously active dopamine neurones in the A9 and A10 area of rat brain: Correlation to receptor profile? (1990) (0)
- Serotonin uptake inhibitors (2014) (0)
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