Josephus J. Heijnen
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Chemistry Engineering
Josephus J. Heijnen's Degrees
- PhD Environmental Engineering University of Amsterdam
- Masters Chemical Engineering Delft University of Technology
- Bachelors Chemical Engineering Delft University of Technology
Why Is Josephus J. Heijnen Influential?
(Suggest an Edit or Addition)Josephus J. Heijnen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The sequencing batch reactor as a powerful tool for the study of slowly growing anaerobic ammonium-oxidizing microorganisms (1998) (1950)
- Microbiology and biochemistry of the enhanced biological phosphate removal process (1998) (957)
- The sharon process: an innovative method for nitrogen removal from ammonium-rich waste water (1998) (947)
- Aerobic granulation in a sequencing batch reactor (1999) (716)
- Simultaneous COD, nitrogen, and phosphate removal by aerobic granular sludge. (2005) (531)
- Mathematical modeling of biofilm structure with a hybrid differential-discrete cellular automaton approach. (1998) (510)
- Filamentous bulking sludge--a critical review. (2004) (498)
- Aerobic granular sludge in a sequencing batch reactor (1997) (437)
- Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards. (2005) (407)
- Stoichiometric model of the aerobic metabolism of the biological phosphorus removal process (1994) (401)
- Aerobic granulation in a sequencing batch airlift reactor. (2002) (401)
- Phosphorus and nitrogen removal with minimal COD requirement by integration of denitrifying dephosphatation and nitrification in a two-sludge system (1996) (394)
- Importance of bacterial storage polymers in bioprocesses (1997) (386)
- Two-dimensional model of biofilm detachment caused by internal stress from liquid flow. (2001) (374)
- Wastewater treatment with particulate biofilm reactors. (2000) (367)
- Microbial metabolomics: past, present and future methodologies (2006) (347)
- Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics. (2009) (335)
- Biological phosphorus removal from wastewater by anaero-bic-anoxic sequencing batch reactor (1993) (327)
- Influence of dissolved oxygen concentration on nitrite accumulation in a biofilm airlift suspension reactor. (1997) (275)
- Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells (2014) (268)
- A thermodynamically based correlation for maintenance gibbs energy requirements in aerobic and anaerobic chemotrophic growth (1993) (258)
- Effect of diffusive and convective substrate transport on biofilm structure formation: a two-dimensional modeling study. (2000) (256)
- Model Based Design of a Novel Process for Nitrogen Removal from Concentrated Flows (1999) (240)
- Poly-β-hydroxybutyrate metabolism in dynamically fed mixed microbial cultures (2002) (239)
- Stoichiometry and kinetics of poly-beta-hydroxybutyrate metabolism in aerobic, slow growing, activated sludge cultures. (2000) (237)
- Leakage-free rapid quenching technique for yeast metabolomics (2008) (222)
- Mathematical modelling of biofilm structures (2002) (221)
- An integrated metabolic model for the aerobic and denitrifying biological phosphorus removal. (1997) (221)
- Correcting mass isotopomer distributions for naturally occurring isotopes. (2002) (220)
- Effects of oxygen concentration on N-removal in an aerobic granular sludge reactor. (2005) (217)
- A metabolic network stoichiometry analysis of microbial growth and product formation (1995) (217)
- When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation (2006) (216)
- Improved rapid sampling for in vivo kinetics of intracellular metabolites in Saccharomyces cerevisiae. (2001) (210)
- Effect of nitrate on phosphorus release in biological phosphorus removal systems (1994) (198)
- A simple method to determine the enantiomeric ratio in enantioselective biocatalysis. (1993) (198)
- N-removal in a granular sludge sequencing batch airlift reactor. (2001) (194)
- Modelling the effect of oxygen concentration on nitrite accumulation in a biofilm airlift suspension reactor (1997) (189)
- Statistical reconciliation of the elemental and molecular biomass composition of Saccharomyces cerevisiae. (2001) (189)
- OCCURRENCE OF DENITRIFYING PHOSPHORUS REMOVING BACTERIA IN MODIFIED UCT-TYPE WASTEWATER TREATMENT PLANTS (1997) (183)
- Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites. (2005) (180)
- Approximative kinetic formats used in metabolic network modeling (2005) (179)
- A sludge characterization assay for aerobic and denitrifying phosphorus removing sludge (1997) (178)
- Measuring enzyme activities under standardized in vivo‐like conditions for systems biology (2010) (174)
- Kinetic modeling of poly(beta-hydroxybutyrate) production and consumption by Paracoccus pantotrophus under dynamic substrate supply. (1997) (173)
- Dynamic simulation and metabolic re-design of a branched pathway using linlog kinetics. (2003) (170)
- Effect of feeding pattern and storage on the sludge settleability under aerobic conditions. (2003) (157)
- Development and application of a differential method for reliable metabolome analysis in Escherichia coli. (2009) (156)
- A theoretical study on the effect of surface roughness on mass transport and transformation in biofilms. (2000) (154)
- A simple hydrodynamic model for the liquid circulation velocity in a full-scale two- and three-phase internal airlift reactor operating in the gas recirculation regime (1997) (154)
- A three-dimensional numerical study on the correlation of spatial structure, hydrodynamic conditions, and mass transfer and conversion in biofilms (2000) (153)
- Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G. (2000) (148)
- Modelling biological phosphorus and nitrogen removal in a full scale activated sludge process (1999) (147)
- Critical evaluation of sampling techniques for residual glucose determination in carbon‐limited chemostat culture of Saccharomyces cerevisiae (2003) (144)
- Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady‐state and highly dynamic conditions (2008) (139)
- Bioenergetics of Microbial Growth (2010) (135)
- Effect of dissolved oxygen concentration on sludge settleability (2003) (117)
- Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains. (2010) (116)
- Rapid sampling for analysis of in vivo kinetics using the BioScope: a system for continuous-pulse experiments. (2002) (115)
- Process intensification in the future production of base chemicals from biomass (2012) (115)
- Optimal re-design of primary metabolism in Escherichia coli using linlog kinetics. (2004) (114)
- Analysis of in vivo kinetics of glycolysis in aerobic Saccharomyces cerevisiae by application of glucose and ethanol pulses (2004) (113)
- Discrete-differential modelling of biofilm structure (1999) (112)
- Glycogen metabolism in aerobic mixed cultures. (2001) (109)
- Metabolic modelling of full-scale biological nitrogen and phosphorus removing wwtp's. (2001) (109)
- An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data. (2011) (103)
- Physiological and technological aspects of large-scale heterologous-protein production with yeasts (2004) (102)
- Simultaneous storage and degradation of PHB and glycogen in activated sludge cultures. (2001) (100)
- A metabolic model for the biological phosphorus removal process (1995) (100)
- Maintenance requirements: energy supply from simultaneous endogenous respiration and substrate consumption (1990) (97)
- The mathematics of metabolic control analysis revisited. (2002) (97)
- Wastewater Treatment with Particulate Biofilm Reactors (2000) (97)
- A more unifying hypothesis for biofilm structures (1997) (96)
- Euler‐Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines (2016) (94)
- In vivo kinetics with rapid perturbation experiments in Saccharomyces cerevisiae using a second-generation BioScope. (2006) (93)
- Simultaneous quantification of free nucleotides in complex biological samples using ion pair reversed phase liquid chromatography isotope dilution tandem mass spectrometry. (2009) (93)
- Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic glucose-limited chemostats. (2005) (93)
- Genome‐derived minimal metabolic models for Escherichia coli MG1655 with estimated in vivo respiratory ATP stoichiometry (2010) (92)
- Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. (2010) (90)
- Scale-down of penicillin production in Penicillium chrysogenum. (2011) (87)
- Effect of iclR and arcA knockouts on biomass formation and metabolic fluxes in Escherichia coli K12 and its implications on understanding the metabolism of Escherichia coli BL21 (DE3) (2011) (87)
- A comprehensive method for the quantification of the non-oxidative pentose phosphate pathway intermediates in Saccharomyces cerevisiae by GC-IDMS. (2009) (83)
- Energetics of growth and penicillin production in a high-producing strain of Penicillium chrysogenum. (2001) (81)
- A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum. (2008) (81)
- Model reduction and a priori kinetic parameter identifiability analysis using metabolome time series for metabolic reaction networks with linlog kinetics. (2009) (81)
- Control of heterotrophic layer formation on nitrifying biofilms in a biofilm airlift suspension reactor. (1997) (80)
- A new framework for the estimation of control parameters in metabolic pathways using lin-log kinetics. (2004) (79)
- Modelling of activated sludge processes with structured biomass. (2002) (79)
- Dynamics of Glycolytic Regulation during Adaptation of Saccharomyces cerevisiae to Fermentative Metabolism (2008) (78)
- Bubble recirculation regimes in an internal-loop airlift reactor (1999) (76)
- Cumulative bondomers: a new concept in flux analysis from 2D [13C,1H] COSY NMR data. (2002) (72)
- Fast dynamic response of the fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses (2009) (71)
- Biological dephosphatation by activated sludge under denitrifying conditions: pH influence and occurrence of denitrifying dephosphatation in a full-scale waste water treatment plant (1997) (70)
- Short-Term Metabolome Dynamics and Carbon, Electron, and ATP Balances in Chemostat-Grown Saccharomyces cerevisiae CEN.PK 113-7D following a Glucose Pulse (2006) (70)
- Rate-based modelling of SO2 absorption into aqueous NaHCO3/Na2CO3 solutions accompanied by the desorption of CO2 (2003) (70)
- Large Scale Anaerobic-Aerobic Treatment of Complex Industrial Waste Water Using Biofilm Reactors (1991) (69)
- Metabolic flux analysis of a glycerol‐overproducing Saccharomyces cerevisiae strain based on GC‐MS, LC‐MS and NMR‐derived 13C‐labelling data (2007) (69)
- Development and Scale-Up of an Aerobic Biofilm Air-Lift Suspension Reactor (1993) (69)
- Bio-augmentation by nitrification with return sludge. (2003) (69)
- Effect of cyclic oxygen exposure on the activity of denitrifying phosphorus removing bacteria (1996) (69)
- Revisiting the 13C‐label distribution of the non‐oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence (2005) (66)
- Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model : Towards rational scale-down and design optimization (2018) (66)
- Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae. (2005) (66)
- Optimization of cold methanol quenching for quantitative metabolomics of Penicillium chrysogenum (2011) (65)
- Innovations in generation and analysis of 2D [(13)C,(1)H] COSY NMR spectra for metabolic flux analysis purposes. (2001) (65)
- Population distribution in aerobic biofilms on small suspended particles (1995) (63)
- Strategy for dynamic process modeling based on neural networks in macroscopic balances (1996) (61)
- Adhesion and biofilm development on suspended carriers in airlift reactors: hydrodynamic conditions versus surface characteristics. (1997) (60)
- Influence of detachment, substrate loading and reactor scale on the formation of biofilms in airlift reactors (1996) (58)
- Formation of Biofilms in a Biofilm Air-Lift Suspension Reactor (1992) (58)
- Intracellular metabolite determination in the presence of extracellular abundance: Application to the penicillin biosynthesis pathway in Penicillium chrysogenum (2010) (57)
- Abrasion of suspended biofilm pellets in airlift reactors: importance of shape, structure, and particle concentrations. (1997) (57)
- Thermodynamics-based design of microbial cell factories for anaerobic product formation. (2015) (56)
- Glucose-methanol co-utilization in Pichia pastoris studied by metabolomics and instationary 13C flux analysis (2013) (56)
- Linear relations in microbial reaction systems: A general overview of their origin, form, and use (1991) (56)
- Kinetics of the reactive absorption of hydrogen sulfide into aqueous ferric sulfate solutions (2003) (55)
- Reductions of 3-oxo Esters by Baker's Yeast: Current Status (1998) (55)
- Model-based evaluation of a new upgrading concept for N-removal. (2002) (55)
- Integrated electrochemical sensor array for on-line monitoring of yeast fermentations. (2006) (54)
- Generating short-term kinetic responses of primary metabolism of Penicillium chrysogenum through glucose perturbation in the bioscope mini reactor. (2006) (54)
- A priori analysis of metabolic flux identifiability from (13)C-labeling data. (2001) (54)
- Quantitative analysis of intracellular coenzymes in Saccharomyces cerevisiae using ion pair reversed phase ultra high performance liquid chromatography tandem mass spectrometry. (2013) (53)
- A method for estimation of elasticities in metabolic networks using steady state and dynamic metabolomics data and linlog kinetics (2006) (53)
- Three-dimensional dual-morphotype species modeling of activated sludge flocs. (2004) (53)
- Monitoring of yeast cell concentration using a micromachined impedance sensor (2005) (52)
- Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum. (2007) (51)
- pH: Keyfactor in the Biological Phosphorus Removal Process (1994) (51)
- Development of quantitative metabolomics for Pichia pastoris (2011) (50)
- In situ product recovery (ISPR) by crystallization: basic principles, design, and potential applications in whole-cell biocatalysis (2006) (50)
- 13C-Labeled Gluconate Tracing as a Direct and Accurate Method for Determining the Pentose Phosphate Pathway Split Ratio in Penicillium chrysogenum (2006) (49)
- Glucose and the ATP paradox in yeast. (2000) (48)
- Metabolism of micro-organisms responsible for enhanced biological phosphorus removal from wastewater, Use of dynamic enrichment cultures (1997) (48)
- Study on the use of NADH fluorescence measurements for monitoring wastewater treatment systems. (2003) (48)
- Influence of different substrates on the formation of biofilms in a biofilm airlift suspension reactor (2000) (48)
- Determination of the Cytosolic NADPH/NADP Ratio in Saccharomyces cerevisiae using Shikimate Dehydrogenase as Sensor Reaction (2015) (47)
- Quantitative physiological study of the fast dynamics in the intracellular pH of Saccharomyces cerevisiae in response to glucose and ethanol pulses. (2008) (46)
- Metabolome dynamic responses of Saccharomyces cerevisiae to simultaneous rapid perturbations in external electron acceptor and electron donor. (2007) (46)
- Feasibility of the thermodynamically controlled synthesis of amoxicillin (1998) (45)
- Relation between dissolved oxygen concentration and ajmalicine production rate in high‐density cultures of Catharanthus roseus (1995) (45)
- Biochemical engineering’s grand adventure (2017) (45)
- Mass transfer and reaction in a biofilm airlift suspension reactor (1998) (45)
- Impact of thermodynamic principles in systems biology. (2010) (44)
- Determination of in vivo oxygen uptake and carbon dioxide evolution rates from off-gas measurements under highly dynamic conditions. (2003) (44)
- Escherichia coli responds with a rapid and large change in growth rate upon a shift from glucose-limited to glucose-excess conditions. (2011) (44)
- Modelling the start-up of a full-scale biological phosphorous and nitrogen removing WWTP. (2002) (43)
- Understanding and applying the extrapolation properties of serial gray-box models (1998) (43)
- Quantitative metabolomics analysis of amino acid metabolism in recombinant Pichia pastoris under different oxygen availability conditions (2012) (43)
- Kinetics of the Enzymatic Resolution of Racemic Compounds in Bi-Bi Reactions (1992) (43)
- A 9‐pool metabolic structured kinetic model describing days to seconds dynamics of growth and product formation by Penicillium chrysogenum (2017) (42)
- Quantitative analysis of metabolites in complex biological samples using ion-pair reversed-phase liquid chromatography-isotope dilution tandem mass spectrometry. (2008) (42)
- High-rate acidophilic ferrous iron oxidation in a biofilm airlift reactor and the role of the carrier material. (2005) (42)
- Immobilization affects the rate and enantioselectivity of 3-oxo ester reduction by baker’s yeast (2002) (41)
- Catching prompt metabolite dynamics in Escherichia coli with the BioScope at oxygen rich conditions. (2010) (41)
- Dynamics of population and biofilm structure in the biofilm airlift suspension reactor for carbon and nitrogen removal (1994) (41)
- In vivo kinetics of primary metabolism in Saccharomyces cerevisiae studied through prolonged chemostat cultivation. (2006) (40)
- Fundamental bottlenecks in the application of continuous bioprocesses. (1992) (40)
- Nitrogen removal using nitrifying biofilm growth and denitrifying suspended growth in a biofilm airlift suspension reactor coupled with a chemostat (1998) (40)
- Determination of elasticities, concentration and flux control coefficients from transient metabolite data using linlog kinetics. (2005) (40)
- Kinetics and stoichiometry in the biological phosphorus removal process with short cycle times (1997) (40)
- Flux response of glycolysis and storage metabolism during rapid feast/famine conditions in Penicillium chrysogenum using dynamic (13)C labeling. (2014) (40)
- Steady-state analysis to evaluate the phosphate removal capacity and acetate requirement of biological phosphorus removing mainstream and sidestream process configurations (1996) (39)
- Influence of temperature on growth and ajmalicine production by Catharantus roseus suspension cultures (2002) (39)
- Metabolic flux and metabolic network analysis of Penicillium chrysogenum using 2D [13C, 1H] COSY NMR measurements and cumulative bondomer simulation. (2003) (39)
- 13C-Labeled metabolic flux analysis of a fed-batch culture of elutriated Saccharomyces cerevisiae. (2007) (39)
- Synthesis of primary amides by lipase-catalyzed amidation of carboxylic acids with ammonium salts in an organic solvent (1999) (39)
- Influence of lid conformation on lipase enantioselectivity (2000) (38)
- Response to comments on “in search of a thermodynamic description of biomass yields for the chemotropic growth of microorganisms” (1993) (38)
- Poly-beta-hydroxybutyrate metabolism in dynamically fed mixed microbial cultures. (2002) (38)
- Metabolic flux control analysis of branch points: an improved approach to obtain flux control coefficients from large perturbation data. (2004) (38)
- Influence of the ethanol and glucose supply rate on the rate and enantioselectivity of 3-oxo ester reduction by baker's yeast. (2001) (37)
- Fast “Feast/Famine” Cycles for Studying Microbial Physiology Under Dynamic Conditions: A Case Study with Saccharomyces cerevisiae (2014) (36)
- Study of the (S)-hydroxynitrile lyase from Hevea brasiliensis: mechanistic implications. (1999) (36)
- Mass transfer limitation as a tool to enhance the enantiomeric excess in the enzymatic synthesis of chiral cyanohydrins (2001) (36)
- Changes in substrate availability in Escherichia coli lead to rapid metabolite, flux and growth rate responses. (2013) (36)
- Hydrolytic activity in baker's yeast limits the yield of asymmetric 3-oxo ester reduction. (2000) (36)
- Isotopic non-stationary 13C gluconate tracer method for accurate determination of the pentose phosphate pathway split-ratio in Penicillium chrysogenum. (2008) (35)
- Improving mixing in microbioreactors (2008) (35)
- Heat Flux Measurements for the Fast Monitoring of Dynamic Responses to Glucose Additions by Yeasts that were Subjected to Different Feeding Regimes in Continuous Culture (1996) (35)
- Degradation of polymers in a biofilm airlift suspension reactor. (2003) (35)
- Fast sampling of the cellular metabolome. (2012) (35)
- Exploration of lipase-catalyzed direct amidation of free carboxylic acids with ammonia in organic solvents (1999) (34)
- Solvent effect on lipase enantioselectivity. Evidence for the presence of two thermodynamic states. (2000) (34)
- Reconstruction of the O2 uptake rate and CO2 evolution rate on a time scale of seconds (2003) (33)
- Nitrogen Removal in Intermittently Aerated Biofilm Airlift Reactor (1998) (32)
- Abrasion of suspended biofilm pellets in airlift reactors: effect of particle size. (1997) (32)
- Process design for nitrogen removal using nitrifying biofilm and denitrifying suspended growth in a biofilm airlift suspension reactor (1997) (31)
- Ajmalicine production by cell cultures of Catharanthus roseus: from shake flask to bioreactor (1994) (30)
- Description of the kinetic mechanism and the enantioselectivity of quinohaemoprotein ethanol dehydrogenase from Comamonas testosteroni in the oxidation of alcohols and aldehydes. (1994) (29)
- Similar temperature dependencies of glycolytic enzymes: an evolutionary adaptation to temperature dynamics? (2012) (29)
- Induction of ajmalicine formation and related enzyme activities in Catharanthus roseus cells: effect of inoculum density (1993) (29)
- In situ product removal using a crystallization loop in asymmetric reduction of 4‐oxoisophorone by Saccharomyces cerevisiae (2004) (29)
- Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach (2011) (29)
- Development of a process model to describe the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase in an aqueous-organic biphasic reactor. (2002) (28)
- Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization. (2002) (28)
- The bioreactor overflow device: an undesired selective separator in continuous cultures? (1991) (28)
- Metabolic flux analysis of a glycerol-overproducing Saccharomyces cerevisiae strain based on GC-MS, LC-MS and NMR-derived C-labelling data. (2007) (27)
- Development of tools for quantitative intracellular metabolomics of Aspergillus niger chemostat cultures (2015) (27)
- Novel insights in transport mechanisms and kinetics of phenylacetic acid and penicillin‐G in Penicillium chrysogenum (2012) (27)
- Competitive lipase-catalyzed ester hydrolysis and ammoniolysis in organic solvents; equilibrium model of a solid-liquid-vapor system. (1999) (27)
- The biofilm airlift suspension extension reactor – II: Three-phase hydrodynamics (2000) (26)
- Diffusion Limitation Causes Decreased Enantioselectivity of Esterification of 2-Butanol by Immobilized Candida Antarctica Lipase B (2001) (26)
- Comparative performance of different scale‐down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis (2018) (26)
- The biofilm airlift suspension extension reactor. Part I : Design and two-phase hydrodynamics (1999) (26)
- Understanding the influence of temperature change and cosolvent addition on conversion rate of enzymatic suspension reactions based on regime analysis. (1999) (26)
- Determination of the in vivo NAD:NADH ratio in Saccharomyces cerevisiae under anaerobic conditions, using alcohol dehydrogenase as sensor reaction (2015) (25)
- Application of metabolome data in functional genomics: a conceptual strategy. (2005) (25)
- Solids retention time in heterotrophic and nitrifying biofilms in a biofilm airlift suspension reactor (1995) (24)
- The use of a metabolically structured model in the study of growth, nitrification, and denitrification by Thiosphaera pantotropha (1990) (24)
- The application of continuous culture for plant cell suspensions. (2001) (24)
- Integration of nitrification and denitrification in biofilm airlift suspension reactors (2000) (24)
- pH-Dependent Uptake of Fumaric Acid in Saccharomyces cerevisiae under Anaerobic Conditions (2011) (24)
- Dynamic 13C-tracer study of storage carbohydrate pools in aerobic glucose-limited Saccharomyces cerevisiae confirms a rapid steady-state turnover and fast mobilization during a modest stepup in the glucose uptake rate. (2009) (23)
- Fermentation broth components influence droplet coalescence and hinder advanced biofuel recovery during fermentation. (2015) (23)
- Formation and Detachment of Biofilms and Granules in a Nitrifying Biofilm Airlift Suspension Reactor (2008) (23)
- Microbial Reduction and in situ Product Crystallization Coupled with Biocatalyst Cultivation during the Synthesis of 6R-Dihydrooxoisophorone (2005) (22)
- Enzymatic formation and esterification of (S)-mandelonitrile (2001) (21)
- Enzyme Kinetics in Monophasic and Biphasic Aqueous-Organic Systems (1992) (21)
- The potential of off-gas analyses for monitoring wastewater treatment plants (1996) (21)
- Design and real time testing of a neural model predictive controller for a nonlinear system (1995) (21)
- Reduction of ethyl 3-oxobutanoate using non-growing baker’s yeast in a continuously operated reactor with cell retention (2002) (21)
- Community structure and co-operation in biofilms: Modelling and predicting biofilm structure (2000) (21)
- Contribution of P-bacteria in biological nutrient removal processes to overall effects on the environment. (2001) (20)
- Modeling and experimental validation of carbon dioxide evolution in alkalophilic cultures (1992) (20)
- Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels (2018) (20)
- Reaction temperature optimization procedure for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase using a process model approach (2002) (19)
- Large‐scale production of diesel‐like biofuels – process design as an inherent part of microorganism development (2013) (19)
- Characterization of an experimental miniature bioreactor for cellular perturbation studies (2006) (19)
- Simple dissolution-reaction model for enzymatic conversion of suspension of solid substrate. (1997) (19)
- Modification of the Enzyme Enantioselectivity by Product Inhibition (1994) (18)
- Nitrification with Biofilms on Small Suspended Particles in Airlift Reactors (1992) (18)
- Predicting enzyme catalyzed reaction equilibria in cosolvent-water mixtures as a function of pH and solvent composition (1998) (18)
- Substrate cycles in Penicillium chrysogenum quantified by isotopic non-stationary flux analysis (2012) (18)
- Limits of Operation for the Integration of Water Removal by Membranes and Crystallization ofl-Phenylalanine (2009) (17)
- Solvent Induced Change of Enzyme Enantioselectivity: Rule Or Exception? (1997) (17)
- Gaseous metabolites and the ajmalicine production rate in high density cell cultures of Catharanthus roseus (1997) (17)
- The negligible role of carbon dioxide and ethylene in ajmalicine production by Catharanthus roseus cell suspensions (1994) (17)
- Gas bubble induced oil recovery from emulsions stabilised by yeast components (2016) (16)
- Biofilm abrasion by particle collisions in airlift reactors (1997) (16)
- New constraints between kinetic parameters explain the (Un)identifiability of enzymatic rate constants. (2000) (16)
- Quantitative metabolomics using ID-MS. (2014) (16)
- Interaction of storage carbohydrates and other cyclic fluxes with central metabolism: A quantitative approach by non-stationary 13C metabolic flux analysis (2016) (16)
- Sequential Kinetic Resolution by two Enantioselective Enzymes (1994) (16)
- Effects of Carbon Dioxide, Air Flow Rate, and Inoculation Density on the Batch Growth of Catharanthus roseus Cell Suspensions in Stirred Fermentors (1994) (16)
- Dynamic in vivo metabolome response of Saccharomyces cerevisiae to a stepwise perturbation of the ATP requirement for benzoate export (2008) (16)
- A structured approach for selection among candidate metabolic network models and estimation of unknown stoichiometric coefficients. (1998) (15)
- Substrate inhibition and product degradation during the reduction of 4-oxoisophorone by Saccharomyces cerevisiae (2005) (15)
- Optimization of the medium composition for alkaloid production by Catharanthus roseus using statistical experimental designs (1992) (15)
- Power dissipation and heat production in bubble columns: Approach based on nonequilibrium thermodynamics (1980) (15)
- Formation of Biofilms on Small Suspended Particles in Airlift Reactors (1992) (14)
- Basic Biotechnology: Stoichiometry and kinetics of microbial growth from a thermodynamic perspective (2006) (14)
- Construction of kinetic models for metabolic reaction networks: Lessons learned in analysing short-term stimulus response data (2011) (14)
- Reconstruction of the oxygen uptake and carbon dioxide evolution rates of microbial cultures at near-neutral pH during highly dynamic conditions (2014) (14)
- Effect of High Product Concentration in a Dual Fed-batch Asymmetric 3-oxo Ester Reduction by Baker's Yeast (2002) (14)
- O uptake rate measurements as a novel tool to study shear effects on suspended strawberry cells (1997) (14)
- Identification of mass transfer parameters in three-phase biofilm reactors (1999) (14)
- A new thermodynamically based correlation of chemotrophic biomass yields (1991) (13)
- Comparison of enzymatic kinetic resolution in a batch reactor and a CSTR (1994) (13)
- Application of the macroscopic electric charge balance in fermentation modeling (1981) (13)
- In vivo kinetic analysis of the penicillin biosynthesis pathway using PAA stimulus response experiments. (2015) (13)
- Use of sequential‐batch fermentations to characterize the impact of mild hypothermic temperatures on the anaerobic stoichiometry and kinetics of Saccharomyces cerevisiae (2012) (13)
- Development of (R)‐4‐hydroxymandelonitrile synthesis in an aqueous–organic biphasic stirred tank batch reactor (2002) (12)
- A system for accurate on-line measurement of total gas consumption or production rates in microbioreactors (2009) (12)
- Improvement of lipase-catalyzed kinetic resolution by tandem transesterification (1995) (11)
- Activity And Enantioselectivity Of Modified Lipases In Organic Solvents (2000) (11)
- Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol (2010) (11)
- Influence of C4-dicarboxylic acid transporters on succinate production (2011) (11)
- Comparative fluxome and metabolome analysis for overproduction of succinate in Escherichia coli (2016) (10)
- Mass balancing in kinetic resolution: calculating yield and enantiomeric excess using chiral balance. (1995) (10)
- A simple structured model for maintenance, biomass formation, and ajmalicine production by nondividing Catharanthus roseus cells. (1999) (10)
- Application of direct fluid flow oscillations to improve mixing in microbioreactors (2009) (9)
- The Sampling and Sample Preparation Problem in Microbial Metabolomics (2013) (9)
- Stoichiometry and kinetics of single and mixed substrate uptake in Aspergillus niger (2017) (9)
- CHAPTER 1:Intensified Fermentation Processes and Equipment (2018) (9)
- The sharon process for nitrogen removal in ammonium rich waste water (1997) (9)
- Fatal attraction in glycolysis: how Saccharomyces cerevisiae manages sudden transitions to high glucose (2014) (9)
- Identification of informative metabolic responses using a minibioreactor: a small step change in the glucose supply rate creates a large metabolic response in Saccharomyces cerevisiae (2012) (9)
- Model-based evaluation of cell retention by crossflow ultrafiltration during fed-batch fermentations with Escherichia coli (2009) (8)
- The Hagen–Poiseuille pump for parallel fed-batch cultivations in microbioreactors (2009) (8)
- Conceptual Evaluation of Integrated Process Configurations for the Recovery of l-Phenylalanine Product Crystals during Fermentation (2010) (8)
- In Vivo Analysis of NH4 + Transport and Central Nitrogen Metabolism in Saccharomyces cerevisiae during Aerobic Nitrogen-Limited Growth (2016) (7)
- Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose‐limited chemostat culture (2016) (7)
- Evaluation of Process Options for Enzymatic Kinetic Resolution (1992) (7)
- Comparison of a batch, fed-batch and continuously operated stirred-tank reactor for the enzymatic synthesis of (R)-mandelonitrile by using a process model (2002) (6)
- Cumulative Bondomers: A New Concept in Flux Analysis from 2D ( 13 C, 1 H) COSY (2002) (6)
- Model-Based Design of Superior Cell Factory: An Illustrative Example of Penicillium chrysogenum (2012) (6)
- Multidimensional modelling of biofilm structure (1999) (6)
- Potential of Enzymatic Kinetic Resolution Using Solid Substrates Suspension: Improved Yield, Productivity, Substrate Concentration, and Recovery (1999) (5)
- Standardization and 'in vivo'-like enzyme activity measurements in yeast (2007) (5)
- Derivation of Enzymatic Rate Equations Using Symbolic Software (1997) (5)
- Determination of δ-[L-α-aminoadipyl]-L-cysteinyl-D-valine in cell extracts of Penicillium chrysogenum using ion pair-RP-UPLC-MS/MS. (2012) (5)
- Large-Scale Production of Secondary Metabolites by Plant Cell Cultures (2020) (4)
- Enzymatic Transformations in Suspensions (II) (2001) (4)
- Rate Based Modeling of a Sulfite Reduction Bioreactor (2005) (4)
- The potentials of off-gas analysis for monitoring and control of waste water treatment plants (1995) (4)
- Poly-β-hydroxyalkanoate metabolism in activated sludge (2001) (4)
- Continuous culture of suspended plant cells (1992) (4)
- Scaleup of ajmalicine production by plant cell cultures of Catharanthus roseus (3)
- A Nletaboiic Network Analysis of Microbial Product Formation Stoichiometry Growth and (1995) (3)
- Solid-to-solid kinetic resolution. Determination of the enantiomeric ratio (1998) (3)
- Enzymatic Resolution of Racemates Contaminated by Racemic Product (1994) (3)
- A three-dimensional numerical study on the correlation of spatial structure, hydrodynamic conditions, and mass transfer and conversion in bio"lms (2000) (3)
- In search of a thermodynamic description of biomass yields for chemotrophic growth of microorganisms (1993) (3)
- Error Diagnosis and Data Reconciliation Using Linear Conservation Relations (1998) (3)
- Removal of pyrite from coal by moderate and extreme thermophiles: evaluation of the consequences for oxygen and carbon dioxide mass transfer. (1989) (3)
- Metabolic Flux Analysis, Modeling, and Engineering Solutions (2003) (2)
- Biological iron oxidation by Thiobacillus ferrooxidans and Leptospirillum ferrooxidans in a biofilm airlift reactor (2004) (2)
- Neural Models in Predictive Control (1995) (2)
- A Thermodynamic Description of Microbial Growth and Product Formation (2009) (2)
- Metabolic network modelling: Improving predictions of microbial metabolism by maximal incorporation of knowledge on biochemical reaction stoichiometry (1995) (2)
- 7 | Lost in Transition Startup of Glycolysis Yields Subpopulations of Non-growing Cells (2015) (1)
- Process Strategies in Enzymatic Racemate Resolution (1994) (1)
- Dynamic in vivo response of aerobic chemostat cultivated E. coli to a substrate pulse (2009) (1)
- Catching prompt metabolite dynamics of E. coli with the BioScope at oxygen rich conditions (2010) (1)
- An Improved Method for Measurement Reconcilation and Gross Error Diagnosis for (Bio)Chemical Processes (1992) (1)
- Use Of Aex-Hplc-Esi-Ms For 13C-Labeling Based Metabolic Flux Analysis In Saccharomyces Cerevisiae And Penicillium Chrysogenum (2009) (1)
- Development of Integrated Sensor Array for Micro Bioreactors (2005) (0)
- Constraints for biotechnological process intensification from metabolic network stoichiometry (1995) (0)
- Metabolic £ uxanalysis ofa glycerol-overproducingSaccharomyces cerevisiae strain based onGC-MS , LC-MSandNMR-derived 13 C-labelling data (2007) (0)
- Abstracts of posters (2012) (0)
- Modeling the metabolism of Penicillin-G formation (2001) (0)
- PREDICTING ENZYME CATALYZED WATER MIXTURES AS A FUNCTION OF pH AND SOLVENT COMPOSITION REACTION EQUILIBRIA IN COSOLVENT (1998) (0)
- Identification of lin-log kinetics for the central metabolism of E. coli (2009) (0)
- Optimizing Mixing in Micro-Bioreactors used for High Throughput Screening of Suitable Biocatalysts in Industrial Fermentation (2005) (0)
- A process for preparing a reaction product by enzymatic catalysis. (1999) (0)
- Dynamic linlog modelling of the central metabolism of E. coli: estimation of elasticities from pulse-response data using gPROMS (2008) (0)
- Metabolic Engineering and Fermentation Technology (1998) (0)
- Nongrowing Cells Lost in Transition : Start-Up of Glycolysis Yields Subpopulations of (2014) (0)
- Programmable balancing of growth and formation of polyhydroxyalkanoates in Escherichia coli (2014) (0)
- Efficient modeling of 13C-labeling distributions in microorganisms (2003) (0)
- Keep your little cells happy in a fed-batch microreactor with integrated sensors and microfluidics (2005) (0)
- Improving industrial biotechnological production processes using modelling based metabolic engineering (2008) (0)
- Development of a technology platform for the production of chemicals from renewable resources (2009) (0)
- Flux and metabolite flexibility in Escherichia coli at seconds time scale in response to rapid shifts of substrate excess (2012) (0)
- DIFFUSION LIMITATION CAUSES DECREASED ENANTIOSELECTIVITY BY IMMOBILIZED CANDZDA ANTARCTICA LIPASE B OF ESTERIFICATION OF 2-BUTANOL (2001) (0)
- Metabolic engineering and metabolic modeling of Escherichia coli for the production of chemicals from renewable resources (MEMORE) (2008) (0)
- Transient chemical stress in Saccharomyces cereviseae and Penicillium chrysogenum (2005) (0)
- Error Detection and Diagnosis (1992) (0)
- Modelling based metabolic engineering for optimization of succinate production in Escherichia coli (2008) (0)
- Effect of Dissolved Carbon Dioxide Concentration on the Metabolism oi Saccharomyces cerevisiae (2009) (0)
- Computational fluid dynamics simulation of an industrial P . chrysogenum fermentation with a coupled 9-pool metabolic model (2017) (0)
- Synthesis of Primary Amides by Lipase-Catalyzed Amidation of Carboxylic Acids with Ammonium Salts in an Organic Solvent. (1999) (0)
- Removal of product crystals during fermentation (2006) (0)
- Optimization of cold methanol quenching for quantitative metabolomics of Penicillium chrysogenum (2011) (0)
- Fast Sampling of the Cellular Metabolome. (2021) (0)
- Exploration of Lipase-Catalyzed Direct Amidation of Free Carboxylic Acids with Ammonia in Organic Solvents. (2000) (0)
- Dynamics of Glycolytic Regulation during Adaptation of <italic toggle='yes'>Saccharomyces cerevisiae</italic> to Fermentative Metabolism <xref ref-type='fn' rid='FN1'>â•€</xref> (2008) (0)
- Application of a differential method for reliable metabolome analysis in chemostat cultivated Escherichia coli 1 2 3 4 5 6 7 8 9 10 11 12 13 (2010) (0)
- Metabolic engineering of E. coli for the production of chemicals (2009) (0)
- TheHagen-Poiseuillepumpforparallelfed-batchcultivationsinmicrobioreactors (2009) (0)
- Design of miniaturized fermentors for high throughput optimization of industrial fermentations (2004) (0)
- L-a-aminoadipate is not the limiting precursor aminoacid in the penicillin biosynthetic pathway in a high producing P. chrysogenym strain (2012) (0)
- New experimental and theoretical tools for metabolic engineering of micro-organisms. (2001) (0)
- Metabolomedynamic responsesofSaccharomyces cerevisiae to simultaneous rapid perturbations in external electronacceptorand electrondonor (2006) (0)
- Fumaric acid Uptake Mechanism in Saccharomyces cerevisiae: Aerobic vs. Anaerobic Conditions (2010) (0)
- Determination of -aminoadipyl - L valine in cell extracts of Penicillium chrysogenum using ion pair-RP-UPLC-MS/MS (2012) (0)
- Development of an accurate method for intracellular metabolome analysis in Escherichia coli for in vivo kinetic analysis (2008) (0)
- KINETICS OF THE ENZYMATIC RESOLUTION REACTIONS OF RACEMIC COMPOUNDS IN BI-BI (1992) (0)
- Analysis of short-term dynamic in vivo response of E. coli to alternative substrate perturbations (2010) (0)
- In vivo estimation of energetic parameters of a metabolic network model for substrate limited growth of E. coli (2009) (0)
- Simplicity makes sence: A (straight) forward apporach to modelling anaerobic yeast metabolism (2012) (0)
- Development of tools for quantitative intracellular metabolomics of Aspergillus niger chemostat cultures (2015) (0)
- A generalized reference state extends the applicability of approximative kinetics in metabolic engineering (2012) (0)
- Development of quantitative metabolomics for Pichia pastoris (2011) (0)
- Influence of microbial cultivation during bio-reduction with in-situ product crystallization (ISPC) (2004) (0)
- Wash-in of U-13C glucose into E. coli cells cultivated in a carbon limited chemostat (2007) (0)
- Delft University of Technology Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic model Towards rational scale-down and design optimization (2018) (0)
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What Schools Are Affiliated With Josephus J. Heijnen?
Josephus J. Heijnen is affiliated with the following schools:
