J. J. Roberts
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J. J. Robertschemistry Degrees
Chemistry
#4148
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Inorganic Chemistry
#221
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#235
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Chemistry
J. J. Roberts's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is J. J. Roberts Influential?
(Suggest an Edit or Addition)J. J. Roberts's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA. (1986) (514)
- The mechanism of action of antitumor platinum compounds. (1979) (396)
- Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds (1972) (230)
- Interactions between mammalian cell DNA and inorganic platinum compounds. I. DNA interstrand cross-linking and cytotoxic properties of platinum(II) compounds. (1974) (186)
- Mechanism of the Cytotoxic Action of Alkylating Agents in Mammalian Cells and Evidence for the Removal of Alkylated Groups from Deoxyribonucleic Acid (1966) (185)
- Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds. (1974) (179)
- The Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals (1978) (177)
- The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2). (1988) (157)
- A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells. (1988) (150)
- Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. I. The effect on HeLa and Chinese hamster cell survival of alkylation of cellular macromolecules. (1971) (140)
- Quantitative aspects of the repair of alkylated DNA in cultured mammalian cells. II. Non-semiconservative DNA synthesis ('repair synthesis') in HeLa and Chinese hamster cells following treatment with alkylating agents. (1971) (132)
- Increased sensitivity of UV-repair-deficient human cells to DNA bound platinum products which unlike thymine dimers are not recognized by an endonuclease extracted from Micrococcus luteus. (1978) (128)
- The enhancement by caffeine of alkylation-induced cell death, mutations and chromosomal aberrations in Chinese hamster cells, as a result of inhibition of post-replication DNA repair. (1974) (123)
- Inhibition of post-replication repair of alkylated DNA by caffeine in Chinese hamster cells but not HeLa cells. (1973) (112)
- 486. Aryl-2-halogenoalkylamines. Part XII. Some carboxylic derivatives of NN-di-2-chloroethylaniline (1953) (102)
- The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) (1991) (101)
- Establishment and characterization of an in vitro model of acquired resistance to cisplatin in a human testicular nonseminomatous germ cell line. (1992) (99)
- Evidence for the inactivation and repair of the mammalian DNA template after alkylation by mustard gas and half mustard gas. (1971) (88)
- Excision repair of cis-diamminedichloroplatinum(II)-induced damage to DNA of Chinese hamster cells. (1979) (87)
- Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: relationship to toxicity. (1987) (84)
- Enhancement by caffeine of N-methyl-N-nitrosourea-induced mutations and chromosome aberrations in Chinese hamster cells. (1973) (82)
- Post-replication repair of DNA in Chinese hamster cells treated with cis platinum (II) diamine dichloride. Enhancement of toxicity and chromosome damage by caffeine. (1975) (74)
- Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species. (1991) (74)
- Sensitive detection of DNA modifications induced by cisplatin and carboplatin in vitro and in vivo using a monoclonal antibody. (1991) (73)
- Quantitative aspects of the formation and loss of DNA interstrand crosslinks in Chinese hamster cells following treatment with cis-diamminedichloroplatinum(II) (cisplatin). II. Comparison of results from alkaline elution, DNA renaturation and DNA sedimentation studies. (1981) (73)
- The role of DNA repair in the recovery of human cells from cisplatin toxicity. (1981) (72)
- The reaction of β-propiolactone with guanosine, deoxyguanylic acid and RNA (1963) (72)
- Persistent Binding of Butter Yellow Metabolites to Rat Liver DNA (1967) (71)
- Platinum Coordination Complexes in Cancer Chemotherapy (1974) (70)
- Studies on the mode of action of tumour-growth-inhibiting alkylating agents—I (1958) (65)
- Quantitative aspects of the formation and loss of DNA interstrand crosslinks in Chinese hamster cells following treatment with cis-diamminedichloroplatinum(II) (cisplatin). I. Proportion of DNA-platinum reactions involved in DNA crosslinking. (1981) (62)
- A novel mechanism for the inhibition of DNA synthesis following methylation: the effect of N-methyl-N-nitrosourea on HeLa cells. (1971) (61)
- Inhibition by caffeine of post-replication repair in Chinese hamster cells treated with cis platinum (II) Diamminedichloride: the extent of platinum binding to template DNA in relation to the size of low molecular weight nascent DNA. (1976) (61)
- CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells. (1986) (59)
- The mode of action of alkylating agents—III: The formation of 3-hydroxytetrahydrothiophene-1:1-dioxide from 1:4-dimethanesulphonyloxybutane (Myleran), S-β-l-alanyltetrahydrothiophenium mesylate, tetrahydro-thiophene and tetrahydrothiophene-1:1-dioxide in the rat, rabbit and mouse (1961) (59)
- Excision of 7-bromomethylbenz[a]anthracene--DNA adducts in replicating mammalian cells. (1977) (55)
- STUDIES OF THE MODE OF ACTION OF ALKYLATING AGENTS. VI. THE METABOLISM OF BIS-2-CHLOROETHYLSULPHIDE (MUSTARD GAS) AND RELATED COMPOUNDS. (1963) (52)
- DNA repair after mustard gas alkylation by sensitive and resistant Yoshida sarcoma cells in vitro. (1970) (51)
- Estimation of interstrand DNA cross-linking resulting from mustard gas alkylation of HeLa cells. (1972) (50)
- Extension of the pre-DNA synthetic phase of the cell cycle as a consequence of DNA alkylation in Chinese hamster cells: a possible mechanism of DNA repair. (1971) (47)
- Walker rat carcinoma cells are exceptionally sensitive to cis-diamminedichloroplatinum(II) (cisplatin) and other difunctional agents but not defective in the removal of platinum-DNA adducts. (1986) (46)
- Inherent sensitivity of cultured human embryonal carcinoma cells to adducts of cis-diamminedichloroplatinum(II) on DNA. (1987) (45)
- DNA as a Target for Anticancer Coordination Compounds (1983) (43)
- The mode of action of alkylating agents. II. Studies of the metabolism of myleran. The reaction of myleran with some naturally occurring thiols in vitro. (1961) (43)
- Platelet activation induced by a murine monoclonal antibody directed against a novel tetra‐span antigen (1995) (41)
- Mode of Action of Alkylating Agents: Formation of S-Ethylcysteine from Ethyl Methanesulphonate In Vivo (1957) (41)
- Genetic aspects of carcinogenesis. (1971) (40)
- Differential toxicity of cis- and trans-diamminedichloroplatinum(II) toward mammalian cells: lack of influence of any difference in the rates of loss of their DNA-bound adducts. (1987) (40)
- The frequency of interstrand cross-links in DNA following reaction of cis-diamminedichloroplatinum(II) with cells in culture or DNA in vitro: stability of DNA cross-links and their repair. (1982) (38)
- Effects of cis-platinum(II) diamminedichloride on survival and the rate of DNA synthesis in synchronously growing Chinese hamster V79-379A cells in the absence and presence of caffeine inhibited post-replication repair; evidence for an inducible repair mechanism. (1978) (37)
- Cellular responses to carcinogen-induced DNA damage and the role of DNA repair. (1980) (34)
- Investigations into the mechanism of action of anti-tumour platinum compounds: time- and dose-dependent changes in the alkaline sucrose gradient sedimentation profiles of DNA from hamster cells treated with cis-platinum (II) diamminedichloride. (1975) (34)
- G1 phase chinese hamster V79-379A cells are inherently more sensitive to platinum bound to their DNA than mid S phase or asynchronously treated cells. (1979) (33)
- Metabolic and Chemical Studies of ‘Myleran’: Formation of 3-Hydroxytetrahydrothiophene-1,1-Dioxide In Vivo, and Reactions With Thiols In Vitro (1959) (33)
- Metabolism of Myleran (1 : 4-Dimethanesulphonyloxybutane) (1959) (33)
- Geomorphology and surficial sediments of the southeast Australian continental margin (2004) (31)
- Effect of 6 weeks of vitamin E administration on renal haemodynamic alterations following a single dose of neoral in healthy volunteers. (2001) (31)
- Environmental Carcinogenesis: Occurrence, Risk Evaluation and Mechanisms (1980) (30)
- The unique sensitivity of Walker rat tumour cells to difunctional agents is associated with a failure to recover from inhibition of DNA synthesis and increased chromosome damage. (1986) (29)
- Effects of cis-platinum(II) diamminedichloride on survival and the rate of DNA synthesis in synchronously growing HeLa cells in the absence and presence of caffeine. (1978) (29)
- The effect of monofunctional or difunctional platinum adducts and of various other associated DNA damage on the expression of transfected DNA in mammalian cell lines sensitive or resistant to difunctional agents. (1987) (28)
- Aryl-2-halogenoalkylamines. Part XIV. Some compounds possessing latent cytotoxic activity (1955) (28)
- Bacterial, Viral and Tissue Culture Studies on Neutral Platinum Complexes (1974) (27)
- Excision of hydrocarbon-DNA adducts and consequent cell survival in normal and repair defective human cells. (1978) (27)
- Potentiation of sulphur mustard or cisplatin-induced toxicity by caffeine in Chinese hamster cells correlates with formation of DNA double-strand breaks during replication on a damaged template. (1986) (26)
- The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink. (1992) (23)
- The independent action of radiation and cisplatin on the survival or recovery of human normal or tumour cells in vitro or in vivo. (1989) (23)
- Plasma membrane as target of alkylating agents. (1985) (22)
- Feeding a creatine analogue delays ATP depletion and onset of rigor in ischemic heart. (1982) (21)
- The excision of N-methyl-N-nitrosourea-induced lesions from the DNA of Chinese hamster cells as measured by the loss of sites sensitive to an enzyme extract that excises 3-methylpurines but not O6-methylguanine. (1979) (21)
- REACTIONS OF CULTURED MAMMALIAN CELLS OF VARYING RADIOSENSITIVITY WITH THE RADIOMIMETIC ALKYLATING AGENT, MUSTARD GAS (1965) (21)
- Mechanism of potentiation by caffeine of genotoxic damage induced by physical and chemical agents. (1984) (20)
- Aryl-2-halogenoalkylamines. Part XIII. Chloroethylamino-derivatives of some phenoxyalkanoic acids and of some substituted α-amino-acids (1955) (19)
- Inhibition by caffeine of post-replication repair in Chinese hamster cells treated with 7-bromomethylbenz(a)anthracene: enhancement of toxicity, chromosome damage and inhibition of ligation of newly-synthesized DNA. (1977) (19)
- Action of Platinum Antitumour Drugs (1983) (18)
- Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells. (1989) (17)
- The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand crosslinks. (1991) (16)
- Azo Dye Liver Carcinogenesis: Reaction of Hydroxymethylaminoazobenzene with Nucleic Acids in vitro (1963) (16)
- Caffeine inhibits excision of 7-bromomethylbenz (a) anthracene-DNA adducts from exponentially growing but not from stationary phase Chinese hamster cells. (1978) (13)
- Evidence for cross linking of complementary strands of dna in cultured mammalian cells by platinum compounds and mustard gas (1972) (13)
- Antitumor Platinum Compounds (1979) (12)
- Synthesis and accumulation of an extremely stable high-energy phosphate compound by muscle, heart, and brain of animals fed the creatine analog, 1-carboxyethyl-2-iminoimidazolidine (homocyclocreatine). (1983) (12)
- Mechanism of action of anti tumor platinum compounds (1987) (12)
- Caffeine-inhibited DNA repair in 7-bromomethylbenz (a)-anthracene-treated Chinease hamster cells: formation of breaks in parental DNA and inhibition of ligation of nascent DNA as a mechanism for enhancement of lethality and chromosome damage. (1978) (11)
- Response of cells to inhibition of synthesis of DNA, RNA and protein. (1971) (10)
- Repair of alkylated DNA in Chinese hamster cells measured by loss of enzyme-sensitive sites in isolated DNA. (1978) (10)
- Toxicity of cisplatin and hydroxymalonatodiammine platinum (II) towards mouse bone marrow and B16 melanoma in relation to DNA binding in vivo. (1982) (9)
- STUDIES OF THE MODE OF ACTION OF TUMOUR-GROWTH-INHIBITING ALKYLATING AGENTS. IV. IN-VITRO REACTIONS OF 2-CHLOROETHYLARYLAMINES. (1963) (9)
- Late Quaternary core stratigraphy of the northern New South Wales continental shelf (2004) (9)
- Higher homolog and N-ethyl analog of creatine as synthetic phosphagen precursors in brain, heart, and muscle, repressors of liver amidinotransferase, and substrates for creatine catabolic enzymes. (1985) (9)
- STUDIES OF THE MODE OF ACTION OF TUMOUR-GROWTH-INHIBITING ALKYLATING AGENTS. V. THE METABOLISM OF 2-CHLOROETHYLARYLAMINES. (1963) (8)
- The testing of thermal-mechanical-hydrological-chemical processes using a large block (1994) (8)
- THE REACTION OF BETA-PROPIOLACTONE WITH GUANOSINE, DEOXYGUANYLIC ACID AND RNA. (1963) (7)
- Properties of mer- HeLa cells sensitive or resistant to the cytotoxic effects of MNU; effects on DNA synthesis and of post treatment with caffeine. (1990) (7)
- Resistivity During Boiling in the SB-15-D Core from the Geysers Geothermal Field: The Effects of Capillarity (1997) (6)
- Aryl-2-halogenoalkylamines. Part XV. Some cationic and basically substituted aryl compounds (1955) (5)
- Comparing geophysical measurements to theoretical estimates for soil mixtures at low pressures (1999) (5)
- 822. Aryl-2-halogenoalkylamines. Part X. The preparation of some derivatives of 1-aryl-3 : 4-dihalogenopyrrolidines and 1 : 4-bisarylamino-2 : 3-dihalogenobutanes (1952) (5)
- Fracture Permeability Evolution in Desert Peak Quartz Monzonite (2005) (5)
- Physical properties of preserved core from The Geysers Scientific Corehole, SB-15D (1996) (4)
- Cyclic nucleotide metabolism in HeLa and Chinese hamster cells after treatment with chlorambucil. (1978) (4)
- Hydrological property measurements of Topopah Spring Tuff (1995) (4)
- Fracture Permeability Evolution in Rock from the Desert Peak EGS Site (2004) (4)
- Laboratory and Field Measurements of Electrical Resistivity to Determine Saturation and Detect Fractures in a Heated Rock Mass (2001) (4)
- Electrical resistivity measurements of brine saturated porous media near reservoir conditions: Awibengkok preliminary results (1999) (4)
- DNA repair mechanisms and cytotoxicity of antitumour alkylating agents and neutral platinum complexes. (1980) (4)
- X-ray tomography of preserved samples from the Geysers scientific corehole (1995) (4)
- Simulating Injectate/Rock Chemical Interaction In Fractured Desert Peak Quartz Monzonite (2005) (3)
- Modeling Fluid Flow and Electrical Resistivity in Fractured Geothermal Reservoir Rocks (2003) (3)
- Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line. (1989) (3)
- Metal Particles in Apollo 17 Impact Melt Breccias: Textures and Highly Siderophile Element Compositions (2013) (3)
- Electrical properties of Topopah Spring tuff as a function of saturation (1994) (3)
- Repair of alkylated DNA in mammalian cells. (1968) (3)
- Report on laboratory tests of drying and re-wetting of intact rocks (1996) (2)
- A heated large block test for high level nuclear waste management (1995) (2)
- Electrical Resistivity as an Indicator of Saturation in Fractured Geothermal Reservoir Rocks: Experimental Data and Modeling (2003) (2)
- Permeability of Fractured Tuff as Functions of Temperature and Confining Pressure (1994) (1)
- Permeability Enhancement in Fine-Grained Sediments by Chemically Induced Clay Fabric Shrinkage (2004) (1)
- Discussion of Dr. Zimmermann's paper (1971) (1)
- Electrical properties of tuff from the ESF as a function of water saturation and temperature (1998) (1)
- Recent developments in the mechanisms of DNA repair and in the role of DNA repair in chemical carcinogenesis and cancer chemotherapy. (1981) (1)
- Conversion of dietary N-Ethylguanidinoacetate by Ehrlich ascites tumor cells and animal tissues to a functionally active analog of creatine phosphate. (1982) (1)
- Effects of boiling on electrical resistivity of microporous rocks from the Geysers (1997) (1)
- Electrical properties of SB-15D rocks at reservoir conditions (1996) (1)
- Fracture Surface Area Effects on Fluid Extraction and the Electrical Resistivity of Geothermal Reservoir Rocks (2002) (1)
- Inhibition by Caffeine of Post-Replication DNA Repair in Hamster Cells Treated with CIS Platinum (II) Diamine Dichloride (1976) (1)
- Constraints on the Nature of Terrestrial Core-Forming Melts: Ultra-High Pressure Transport Property Measurements and X-Ray Computed Tomography Final Report (2006) (0)
- Repair of alkylated DNA in mammalian cells. (1972) (0)
- MULTIPLE SYNTHESIS ROUTES TO TRANSPARENT (2008) (0)
- Ageing, carcinogenesis and radiation biology, the role of nucleic acid addition reactions: edited by K. C. Smith, published by Plenum Press, New York and London, 1976. $47.40 (approx £25.-) (xi+561 pages) (1976) (0)
- Microstructural Analyses of Topopah Spring Tuff from the Large Block Test at Fran Ridge, Nevada (2000) (0)
- Jean-Pierre Macquet, 1943–1984 (1984) (0)
- Geomechanics Investigations in Support of the Large Block Test at Fran Ridge, Nye County, Nevada (1994) (0)
- X-Ray Microtomography of Olivine-Basalt Partial-Melts (2002) (0)
- X-Ray Evidence for Capillary Pressure Driven Flow in Preserved Core from the Geysers (1997) (0)
- Moisture Retention Curves of Topopah Spring Tuff at Elevated Temperatures (2001) (0)
- Relating x-ray attenuation measurements to water content and distribution in SB-15D core (1996) (0)
- Olivine-FeS Partial-Melt (2006) (0)
- Discussion of Dr. Farber's paper (1971) (0)
- Excision repair of 7–bromomethylbenz(a)anthracene damage in Chinese hamster and HeLa cells (1977) (0)
- Ageing, Carcinogenesis and Radiation Biology, the Role of Nucleic Acid Addition Reactions, K.C. Smith (Ed.). Plenum Press, London (1976) (1976) (0)
- The story of cancer. On its nature, causes and control: By Armin C. Braun. Pp 308. Addison‐Wesley Publishing Company, Reading, Mass. U.S.A., Advanced Book Program, 1977. Hardback, $19.50, paperback $9.50 (1978) (0)
- Analytical Methods for Studying the Interactions of Chemical Carcinogens with Nucleic Acids (1975) (0)
- Proceedings: Synergism between the anti-tumour agent cis platinum (II) diamminedichloride and caffeine: toxicological and molecular studies. (1975) (0)
- Experimental tests of enhancement of thermal vapor diffusion in Topopah Spring Tuff (1997) (0)
- Report on laboratory scale thermally-coupled processes experiments (1998) (0)
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