John K. Spitznagel
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John K. Spitznagelbiology Degrees
Biology
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Cell Biology
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Molecular Biology
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Biochemistry
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Biology
John K. Spitznagel's Degrees
- PhD Biochemistry University of California, San Francisco
- Bachelors Chemistry University of California, Berkeley
Why Is John K. Spitznagel Influential?
(Suggest an Edit or Addition)John K. Spitznagel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Character of azurophil and specific granules purified from human polymorphonuclear leukocytes. (1974) (324)
- Antibacterial and Enzymic Basic Proteins from Leukocyte Lysosomes: Separation and Identification (1963) (207)
- Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate (1984) (199)
- Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes II. Composition, Properties, and Mechanism of Antibacterial Action (1966) (183)
- Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence (1993) (174)
- ARGININE-RICH PROTEINS OF POLYMORPHONUCLEAR LEUKOCYTE LYSOSOMES : ANTIMICROBIAL SPECIFICITY AND BIOCHEMICAL HETEROGENEITY (1968) (165)
- Antibiotic proteins of human neutrophils. (1990) (156)
- CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. (1990) (152)
- Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes. (1977) (146)
- Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes I. Resolution of Antibacterial and Enzymatic Activities (1966) (145)
- Association of Lactoferrin with Lysozyme in Granules of Human Polymorphonuclear Leukocytes (1972) (124)
- Microbial Diversity of Biofilms in Dental Unit Water Systems (2003) (116)
- Immunocytochemical localization of myeloperoxidase, lactoferrin, lysozyme and neutral proteases in human monocytes and neutrophilic granulocytes. (1978) (111)
- An enzyme-linked immunoassay (ELISA) for measurement of lactoferrin. (1983) (105)
- Immunocytochemical identification of azurophilic and specific granule markers in the giant granules of Chediak-Higashi neutrophils. (1978) (104)
- Fate of human lactoferrin and myeloperoxidase in phagocytizing human neutrophils: effects of immunoglobulin G subclasses and immune complexes coated on latex beads (1975) (102)
- Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granulocytes (1986) (95)
- Susceptibility of Lipopolysaccharide Mutants to the Bactericidal Action of Human Neutrophil Lysosomal Fractions (1977) (93)
- Regulation of leukotoxin in leukotoxic and nonleukotoxic strains of Actinobacillus actinomycetemcomitans (1991) (91)
- Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. (1993) (90)
- Mode of action of adjuvants: retinol and other lysosome-labilizing agents as adjuvants. (1970) (89)
- Mode of action of adjuvants: effects on antibody responses to macrophage-associated bovine serum albumin. (1970) (89)
- Antimicrobial Specificity of Leukocyte Lysosomal Cationic Proteins (1966) (83)
- Early degranulation of human neutrophils: Immunocytochemical studies of surface and intracellular phagocytic events (1979) (80)
- Nonoxidative antimicrobial reactions of leukocytes. (1984) (79)
- Peroxidaseless chicken leukocytes: isolation and characterization of antibacterial granules. (1973) (78)
- Lipid A and resistance of Salmonella typhimurium to antimicrobial granule proteins of human neutrophil granulocytes (1984) (74)
- Chicken neutrophils: oxidative metabolism in phagocytic cells devoid of myeloperoxidase. (1975) (74)
- Amino acid sequence of CAP37, a human neutrophil granule‐derived antibacterial and monocyte‐specific chemotactic glycoprotein structurally similar to neutrophil elastase (1990) (72)
- Neutrophil killing of bacteria by oxygen-independent mechanisms: a historical summary. (1985) (72)
- Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. (1991) (70)
- Molecular and Structural Damage to Escherichia coli Produced by Antibody, Complement, and Lysozyme Systems (1968) (70)
- Subcellular distribution of superoxide dismutases in human neutrophils. Influence of myeloperoxidase on the measurement of superoxide dismutase activity. (1977) (69)
- Microbicidal Activity of Peroxidaseless Chicken Heterophile Leukocytes (1972) (68)
- The role of lysosomes in hypersensitivity reactions: tissue damage by polymorphonuclear neutrophil lysosomes. (1965) (68)
- CATIONIC PROTEINS AND ANTIBACTERIAL PROPERTIES OF INFECTED TISSUES AND LEUKOCYTES. (1963) (67)
- Differential distribution of distinct forms of myeloperoxidase in different azurophilic granule subpopulations from human neutrophils. (1983) (67)
- Compartmentalization of cyclic AMP during phagocytosis by human neutrophilic granulocytes. (1981) (66)
- Cationic Protein-Bearing Granules of Polymorphonuclear Leukocytes: Separation from Enzyme-Rich Granules (1969) (65)
- Distribution of Lysosomal Enzymes, Cationic Proteins, and Bactericidal Substances in Subcellular Fractions of Human Polymorphonuclear Leukocytes (1971) (61)
- cis Elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans (1996) (61)
- Phospholipase A activity associated with membranes of human polymorphonuclear leucocytes. (1977) (61)
- cDNA cloning of human myeloperoxidase: decrease in myeloperoxidase mRNA upon induction of HL-60 cells. (1987) (59)
- Bactericidal activity of fractionated granule contents from human polymorphonuclear leukocytes: antagonism of granule cationic proteins by lipopolysaccharide (1979) (58)
- Pyrogenicity of granulocyte lysosomes. (1966) (55)
- Isolation and characterization of a gene, pmrD, from Salmonella typhimurium that confers resistance to polymyxin when expressed in multiple copies (1994) (52)
- Comparison of NADH and NADPH oxidase activities in granules isolated from human polymorphonuclear leukocytes with a fluorometric assay. (1977) (52)
- Immunocytochemical distinction between primary and secondary granule formation in developing human neutrophils: correlations with Romanowsky stains. (1979) (52)
- O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils (1989) (52)
- Neisseria gonorrhoeae survive intraleukocytic oxygen-independent antimicrobial capacities of anaerobic and aerobic granulocytes in the presence of pyocin lethal for extracellular gonococci (1986) (51)
- Bactericidal Activity of Specific and Azurophil Granules from Human Neutrophils: Studies with Outer-Membrane Mutants of Salmonella typhimurium LT-2 (1978) (49)
- Lysosomal enzymes in inflammatory synovial effusions. (1979) (49)
- Lipopolysaccharide structure determines ionic and hydrophobic binding of a cationic antimicrobial neutrophil granule protein (1988) (45)
- The Regulation of Leukotoxin Production in Actinobacillus Actinomycetemcomitans Strain JP2 (1995) (45)
- Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease. (1978) (42)
- Protease inhibitors in inflammatory synovial effusions. (1981) (42)
- Bactericidal activity of fractionated granule contents from human polymorphonuclear leukocytes (1979) (41)
- Anaerobiosis increases resistance of Neisseria gonorrhoeae to O2-independent antimicrobial proteins from human polymorphonuclear granulocytes (1985) (40)
- Normal Serum Cytotoxicity for P32-Labeled Smooth Enterobacteriaceae I. Loss of Label, Death, and Ultrastructural Damage (1966) (37)
- CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. (1990) (37)
- Isozymes of lysozyme in leukocytes and egg white: evidence for the species-specific control of egg-white lysozyme synthesis. (1974) (36)
- Outer membrane mutants of Salmonella typhimurium LT2 have lipopolysaccharide-dependent resistance to the bactericidal activity of anaerobic human neutrophils (1982) (35)
- Microbial interactions with neutrophils. (1983) (34)
- Resistance to antimicrobial chemotherapy: a prescription for research and action. (1998) (34)
- ARGININE-RICH PROTEINS OF POLYMORPHONUCLEAR LEUKOCYTE LYSOSOMES (1968) (31)
- THE EFFECTS OF MAMMALIAN AND OTHER CATIONIC POLYPEPTIDES ON THE CYTOCHEMICAL CHARACTER OF BACTERIAL CELLS (1961) (28)
- Bactericidal capacity of phorbol myristate acetate-treated human polymorphonuclear leukocytes (1978) (28)
- Subcellular distribution of glycosidases in human polymorphonuclear leucocytes. (1978) (28)
- Cleavage of membrane bound C3bi, an intermediate of the third component of complement, to C3c and C3d-like fragments by crude leucocyte lysosomal lysates and purified leucocyte elastase. (1981) (27)
- Immunocytochemical identification of abnormal polymorphonuclear neutrophils in patients with leukemia. (1978) (27)
- Ultrastructural localization of cationic proteins in cytoplasmic granules of chicken and rabbit polymorphonuclear leukocytes. (1975) (25)
- The ontogeny of a 57-Kd cationic antimicrobial protein of human polymorphonuclear leukocytes: localization to a novel granule population. (1990) (24)
- Gonococci with mutations to low-level penicillin resistance exhibit increased sensitivity to the oxygen-independent bactericidal activity of human polymorphonuclear leukocyte granule extracts (1982) (24)
- Rat arthritis due to whole group B streptococci. Clinical and histopathologic features compared with groups A and D. (1983) (24)
- Isolation and characterization of an acidic chemotactic factor from complement-activated human serum. (1980) (23)
- Normal Serum Cytotoxicity for P32-Labeled Smooth Enterobacteriaceae II. Fate of Macromolecular and Lipid Phosphorus of Damaged Cells (1966) (22)
- The ontogeny of a 57-Kd cationic antimicrobial protein of human polymorphonuclear leukocytes: localization to a novel granule population (1990) (20)
- Characteristics of Complement-Dependent Release of Phospholipid from Escherichia coli (1971) (20)
- Subcellular localization of NAD(P)H oxidase(s) in human neutrophilic polymorphonuclear leucocytes. (1978) (20)
- Characterization of cationic protein-bearing granules of polymorphonuclear leukocytes. (1971) (19)
- Normal Serum Cytotoxicity for P32-Labeled Smooth Enterobacteriaceae III. Isolation of a γG Normal Antibody and Characterization of Other Serum Factors Causing P32 Loss (1966) (18)
- A 59 kiloDalton outer membrane protein of Salmonella typhimurium protects against oxidative intraleukocytic killing due to human neutrophils (1990) (18)
- Antibacterial Action of PMN Lysosomal Cationic Proteins Resolved By Density Gradient Electrophoresis.∗ (1966) (18)
- A monoclonal antibody that inhibits the antimicrobial action of a 57 KD cationic protein of human polymorphonuclear leukocytes. (1987) (18)
- Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins (1988) (17)
- Antimicrobial binding of a radiolabeled cationic neutrophil granule protein (1987) (17)
- A FRACTION OF TUBERCLE BACILLI POSSESSING PRIMARY TOXICITY (1955) (16)
- Quantitation of a cationic antimicrobial granule protein of human polymorphonuclear leukocytes by ELISA. (1989) (15)
- Myeloperoxidase-Cl--H2O2 bactericidal system: effect of bacterial membrane structure and growth conditions (1978) (15)
- ANTIBACTERIAL EFFECTS ASSOCIATED WITH CHANGES IN BACTERIAL CYTOLOGY PRODUCED BY CATIONIC POLYPEPTIDES (1961) (15)
- Nonoxidative antimicrobial effects of human polymorphonuclear leukocyte granule proteins on Chlamydia spp. in vitro (1987) (15)
- Molecular approaches to leucotoxin as a virulence component in Actinobacillus actinomycetemcomitans. (1990) (15)
- Interaction of human polymorphonuclear leukocyte elastase with human IgM In vitro production of an Fabmu-like fragment. (1979) (14)
- Proteolysis of human IgG by human polymorphonuclear leucocyte elastase produces an Fc fragment with in vitro biological activity. (1979) (14)
- Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases. (1991) (14)
- Bactericidal mechanisms of the granulocyte. (1977) (10)
- Oxygen-Independent Antimicrobial Systems in Polymorphonuclear Leukocytes (1980) (10)
- Modulation of complement fixation and the phlogistic capacity of group A, B, and D streptococci by human lysozyme acting on their cell walls (1986) (10)
- MAGNESIUM AND SULFATE IONS AS DETERMINANTS IN THE GROWTH AND REPRODUCTION OF MYCOBACTERIUM BOVIS (1959) (9)
- An epizootic due to pneumococcus type II in laboratory rats. (1950) (8)
- BASIC PROTEINS AND LEUKOCYTE LYSOSOMES AS BIOCHEMICAL DETERMINANTS OF RESISTANCE TO INFECTION. (1964) (7)
- Origins and development of peptide antibiotic research (1998) (7)
- In vitro production of a biologically active Fab2-like fragment by digestion of human IgG rheumatoid factor with human polymorphonuclear leukocyte elastase. (1979) (6)
- Isolation of polymorphonuclear leukocyte granules from rabbit bone marrow. (1971) (6)
- Antimicrobial Specificity and Biochemical Heterogeneity* (6)
- Specificity of PPD skin tests in childhood tuberculin converters: comparison with mycobacterial species from tissues and secretions. (1970) (6)
- Toxicity of group B Streptococcus agalactiae in adult rats (1985) (5)
- Oxygen independent microbicidal mechanisms of human polymorphonuclear leukocytes. (1983) (5)
- Neutral proteases of human polymorphonuclear granulocytes: putative mediators of pulmonary damage. (1980) (5)
- NormalSerumCytotoxicity forP32-Labeled Smooth Enterobacteriaceae I.LossofLabel, Death, andUltrastructural Damage (1966) (4)
- Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug (1975) (4)
- Effects of cortisone and ACTH in mumps meningo-encephalitis. (1958) (4)
- Molecular genetics of polymyxin resistance in Salmonella typhimurium. (1995) (4)
- Oxygen-independent antimicrobial action in sphingosine-treated neutrophils. (1989) (3)
- Immunogenicity of bovine serum albumin and its oligopolymers in CBA mice. (1972) (3)
- Peritoneal Macrophages of Pathogen‐Free Rats but not of Conventional Rats Secrete Elastolytic Activity (1984) (3)
- Origins and development of peptide antibiotic research. From extracts to abstracts to contracts. (1998) (2)
- Characterization of rat polymorphonuclear leukocyte subcellular granules. (1982) (2)
- Protease inhibitors ininflammatory synovial effusions (1981) (2)
- MACROMOLECULE SYNTHESIS IN LONG FORMS OF MYCOBACTERIUM BOVIS INDUCED BY SULFATE DEFICIENCY (1961) (2)
- Quantitative studies on induction of active immunity to smooth, V form Salmonella typhosa; a comparison of antigenicity of heat-killed and Formalin-killed bacterial suspensions. (1949) (2)
- Characteristics ofComplement-Dependent Release of Phospholipid fromEscherichia coli (1971) (2)
- A comparative analysis of human IgM rheumatoid factor degradation by purified elastase and total granule extracts from human polymorphonuclear leukocytes (1980) (1)
- 116; CAP37, A MULTIFUNCTIONAL NEUTROPHIL PROTEIN WITH LIPOPOLYSACCHARIDE (LPS) BINDING ACTIVITY (1994) (1)
- Interaction of human polymorphonuclear leukocyte (PMN) elastase with human IgM. Production of a factor enhancing PMN migration in vitro. (1980) (1)
- Bactericidal activity in fractionated granule contents from human polymorphonuclear leukocytes: studies with leukocytes from normal individuals (1981) (1)
- Selective modification of rat peritoneal macrophage lysosomal hydrolases by inflammatory stimuli. (1982) (1)
- Transfer of granule proteins of human neutrophils into phagosomes and extracellular medium (1973) (1)
- Microbial cells as determinants of intra leukocytic degradation (1979) (1)
- Antibiotic Proteins of Human Neutrophils: Interaction with the Surface of Salmonella (1993) (1)
- A mutation in Salmonella typhimurium that enhances resistance to oxygen-independent antimicrobal neutrophil protein. (1988) (1)
- Program and Abstracts of the TWENTY‐FIFTH NATIONAL MEETING of THE SOCIETY FOR LEUKOCYTE BIOLOGY (1988) (0)
- Longitudinal study of igg responses to actinobacillus actinomycetemcomitans in periodontal disease pd (1988) (0)
- Isolation of a ' yG Normal Antibody and Characterization of Other Serum Factors Causing pI 2 Loss (0)
- Spontaneous pmrAMutants ofSalmonella typhimurium LT2 Define aNewTwo-Component Regulatory System withaPossible RoleinVirulence (1993) (0)
- Distribution ofLysosomal Enzymes, Cationic Proteins, andBactericidal Substances in Subcellular Fractions ofHuman Polymorphonuclear (1971) (0)
- Structure Determines Ionic andHydrophobic Binding ofa Cationic Antimicrobial Neutrophil Granule Protein (1988) (0)
- A FRACTION OF TUBERCLE BACILLI POSSESSING PRIMARY (2003) (0)
- Cationic antimicrobial proteins (CAP): antibiotic-like mediators in oxygen independent antimicrobial actions of neutrophils (2011) (0)
- Effects of adjuvant and antigen on immunogenicity of macrophage associated bsa. Abstr. (1969) (0)
- EFFECTS OF POLYPEPTIDES ON BACTERIAL CELLS (2003) (0)
- Cationic Antimicrobial Neutrophil Granule Protein (0)
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