John M. Chirgwin
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John M. Chirgwinbiology Degrees
Biology
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#9838
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Molecular Biology
#769
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#787
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Biochemistry
#940
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#1049
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Biology
John M. Chirgwin's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is John M. Chirgwin Influential?
(Suggest an Edit or Addition)John M. Chirgwin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. (1979) (19276)
- Rat insulin genes: construction of plasmids containing the coding sequences. (1977) (1026)
- TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. (1999) (1025)
- Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. (1987) (631)
- Isolation of RNA using guanidinium salts. (1987) (567)
- Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases (2006) (485)
- Cathepsin D and prognosis in breast cancer. (1990) (475)
- A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases (2003) (389)
- Cloning and sequence analysis of cDNA for human cathepsin D. (1985) (274)
- RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon (1985) (255)
- Transforming Growth Factor-β Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways* (2002) (251)
- Molecular biology of bone metastasis. (2008) (240)
- Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway. (2005) (236)
- Molecular mechanisms of tumor-bone interactions in osteolytic metastases. (2000) (228)
- Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment (2009) (209)
- Molecular Biology of Bone Metastasis (2007) (205)
- Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation. (2007) (176)
- The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone. (2015) (172)
- Molecular mechanisms of breast cancer metastases to bone. (2005) (161)
- Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. (2016) (160)
- Polymorphism in the 5' flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes. (1983) (147)
- The critical role of the bone microenvironment in cancer metastases (2009) (141)
- Transforming growth factor-beta in osteolytic breast cancer bone metastases. (2003) (139)
- Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. (2002) (131)
- Human renin gene: structure and sequence analysis. (1984) (127)
- A Lack of Genetic Linkage of Renin Gene Restriction Fragment Length Polymorphisms With Human Hypertension (1989) (124)
- 46 kd mannose 6-phosphate receptor: Cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor (1987) (120)
- Solubility of proteins isolated from inclusion bodies is enhanced by fusion to maltose-binding protein or thioredoxin. (1998) (110)
- Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. (2005) (110)
- Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor. (1987) (106)
- Characterization of the two nonallelic genes encoding mouse preproinsulin (2005) (104)
- The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia. (2001) (101)
- Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. (1994) (98)
- Computer graphics modelling of human renin (1984) (97)
- Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes. (1981) (94)
- Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases (2007) (93)
- Effects of Glucose on Proinsulin Messenger RNA in Rats In Vivo (1982) (89)
- Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis. (2006) (79)
- Order of fusions between bacterial and mammalian proteins can determine solubility in Escherichia coli. (1998) (78)
- Renin, a secretory glycoprotein, acquires phosphomannosyl residues (1987) (77)
- Isolation of RNA. (1989) (73)
- Fusions to maltose-binding protein: control of folding and solubility in protein purification. (2000) (73)
- Tumor-bone cellular interactions in skeletal metastases. (2004) (72)
- Expression of cloned bovine adrenal rhodanese. (1991) (71)
- Changes in the frequency of specific transcripts during development of the pancreas. (1977) (67)
- New insights into the role of T cells in the vicious cycle of bone metastases (2006) (63)
- Halofuginone inhibits the establishment and progression of melanoma bone metastases. (2012) (62)
- Pseudoisoenzymes of rabbit muscle phosphoglucose isomerase. (1972) (62)
- An analysis of pancreatic development: role of mesenchymal factor and other extracellular factors. (1978) (59)
- Folding of an enzyme into an active conformation while bound as peptidyl-tRNA to the ribosome. (1995) (55)
- The effects of fasting and feeding on preproinsulin messenger RNA in rats. (1981) (54)
- Genetic analysis of the hypervariable region flanking the human insulin gene. (1986) (54)
- The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells. (2007) (53)
- Rat insulin genes: construction of plasmids containing the coding sequences. 1977. (1992) (51)
- Cloning and characterization of the 5′‐flanking region of the mouse tartrate‐resistant acid phosphatase gene (1993) (47)
- Transcriptional activation of cathepsin D gene expression by growth factors. (2000) (45)
- The enediolate analogue 5-phosphoarabinonate as a mechanistic probe for phosphoglucose isomerase. (1975) (45)
- Properties of Soluble Fusions Between Mammalian Aspartic Proteinases and Bacterial Maltose-Binding Protein (1999) (44)
- The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. (2004) (41)
- Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis (2014) (39)
- Skeletal metastases: Decreasing tumor burden by targeting the bone microenvironment (2007) (39)
- FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells (2015) (38)
- Assessing new bone formation in neonatal calvarial organ cultures. (2008) (38)
- Role of bone-anabolic agents in the treatment of breast cancer bone metastases (2014) (34)
- REPRODUCTIVE TISSUE RENIN GENE EXPRESSION IN PREECLAMPSIA (2000) (32)
- Recombinant bovine rhodanese: purification and comparison with bovine liver rhodanese. (1992) (32)
- Role of glycosylation in the expression of human procathepsin D. (1995) (32)
- Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis (2017) (31)
- Regulation of Postnatal Trabecular Bone Formation by the Osteoblast Endothelin A Receptor (2011) (28)
- The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis (2018) (28)
- Mannose 6-Phosphate Receptor (2003) (27)
- Purification, Amino Acid Sequence, and cDNA Sequence of a Novel Calcium-Precipitating Proteolipid Involved in Calcification of Corynebacterium matruchotii (1998) (27)
- Rapid secretion by a nonclassical pathway of overexpressed mammalian mitochondrial rhodanese. (1994) (26)
- Human renin gene is on chromosome 1 (1984) (26)
- The structure of human phosphoglucose isomerase complexed with a transition-state analogue. (2003) (26)
- The Propeptide Is Nonessential for the Expression of Human Cathepsin D (*) (1995) (25)
- Chromosome localization of the human renin gene (REN) by in situ hybridization. (1987) (24)
- Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues (1985) (24)
- Mechanistic implications of the pH independence of inhibition of phosphoglucose isomerase by neutral sugar phosphates. (1975) (23)
- NH2-terminal Sequence Truncation Decreases the Stability of Bovine Rhodanese, Minimally Perturbs Its Crystal Structure, and Enhances Interaction with GroEL under Native Conditions* (1999) (22)
- Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function. (2008) (21)
- Proinsulin I and II gene expression in inbred mouse strains. (1989) (21)
- Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma. (2016) (20)
- Chinese hamster ovarian cells transfected with human parathyroid hormone-related protein cDNA cause hypercalcemia in nude mice. (1992) (18)
- Glucose regulated insulin biosynthesis in isolated rat pancreatic islets is accompanied by changes in proinsulin mRNA. (1985) (18)
- Truncations at the NH2 Terminus of Rhodanese Destabilize the Enzyme and Decrease Its Heterologous Expression* (1998) (18)
- Insulin biosynthesis and diabetes mellitus. (1981) (18)
- Role of bisphosphonates in prostate cancer bone metastases. (2003) (15)
- Mouse kidney renin gene is on chromosome one (1984) (14)
- Mutations of noncatalytic sulfhydryl groups influence the stability, folding, and oxidative susceptibility of rhodanese. (1994) (14)
- Linkage analysis of Charcot-Marie-Tooth neuropathy (HMSN type I) (1987) (13)
- Insulin Gene Structure and Function: A Review of Studies Using Recombinant DNA Methodology (1984) (13)
- Breaking new ground to build bone (2007) (12)
- Lysine residues in the C-terminal lobe and lysosomal targeting of procathepsin D. (1995) (12)
- Does Prostate-Specific Antigen Contribute to Bone Metastases? (2006) (11)
- The stem cell niche as a pharmaceutical target for prevention of skeletal metastases. (2012) (9)
- Rabbit phosphoglucose isomerase/neuroleukin/autocrine motility factor: cloning via interspecies identity. (2000) (8)
- Binding studies on rabbit-muscle phosphoglucose isomerase. (1973) (8)
- Agents targeting prostate cancer bone metastasis. (2009) (6)
- Efficient mutagenesis, expression and purification of procathepsin D. (1991) (6)
- Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures. (1993) (6)
- Analysis of Insulin Gene Expression in Human Pancreas (1983) (6)
- The potential role of procathepsin D secreted by breast cancer cells in bone resorption (1990) (5)
- Human insulin-related DNA sequences map to chromosomes 2 and 11 (1986) (5)
- Preformed GroES Oligomers Are Not Required as Functional Cochaperonins (1997) (5)
- Immunological evidence for a conformational difference between recombinant bovine rhodanese and rhodanese purified from bovine liver (1992) (5)
- Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo. (2020) (5)
- Molecular mechanisms of cancer metastases to bone (2003) (5)
- Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D (2016) (5)
- Mapping of lysosomal targeting determinants of cathepsin D. (1991) (4)
- Chinese hamster rhodanese cDNA: activity of the expressed protein is not blocked by a C-terminal extension. (1995) (4)
- Elimination of glycerol artifacts in cycle sequencing. (1993) (4)
- Interactions between tumor and bone alter the phenotypes of both. (2003) (4)
- TGF β signaling in osteolytic cancer cell lines: Stimulation of IL-6, IL-11, PTHrP, and VEGF through MAP kinase pathways (2001) (3)
- Molecular Biology for Nonmolecular Biologists (1990) (3)
- TGF (cid:69) Stimulates Parathyroid Hormone-Related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways (2002) (3)
- The genetics of type I and type II diabetes: analysis by recombinant DNA methodology. (1985) (3)
- PANCREAS SPECIFIC GENES AND THEIR EXPRESSION DURING DIFFERENTIATION (1978) (2)
- Small molecules inhibit ex vivo tumor growth in bone. (2018) (2)
- Pathophysiology of Bone Metastases (2014) (2)
- Specificity, catalytic activity and intron-exon junctions (1984) (2)
- Synthesis of 1-chloro-2-oxohexanol 6-phosphate, a covalent active-site reagent for phosphoglucose isomerase. (1981) (2)
- Aromatase inhibitors associated with knee subchondral bone expansion without cartilage loss (2013) (2)
- Breast cancer secreted factors alter the bone microenvironment (2007) (2)
- 5 Phosphoarabonate as a potential 'transition state analogue' for phosphoglucose isomerase (1973) (1)
- The structure and expression of the insulin gene (1978) (1)
- Ligand Pathway B κ Independent of the Receptor Activator of Nuclear Factor-Tumor-Derived Interleukin-8 Stimulates Osteolysis (2005) (1)
- ROLE OF CD166 IN MULTIPLE MYELOMA CELL HOMING TO THE BONE MARROW MICROENVIRONMENT AND DISEASE PROGRESSION (2013) (1)
- Crystal structure of mouse phosphoglucose isomerase (2004) (1)
- Meeting report from skeletal complications of malignancy IV (2006) (1)
- Cell adhesion molecule CD 166 drives malignant progression and osteolytic disease in multiple myeloma (2016) (1)
- The multiple roles of the NH2-terminal sequence of rhodanese (1997) (0)
- Abstract 367: The heparan sulfate mimetic PG545 inhibits tumor growth in both male and female mouse model of pancreatic ductal adenocarcinoma (PDAC) with sex difference in the effect on cachexia (2023) (0)
- Abstract 693: Effects of a bone-anabolic agent on metastatic bone cancer growth (2020) (0)
- A recombinant DNA transfer vector (1991) (0)
- Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis (2014) (0)
- Osteocyte-derived FGF23 activates EGR-1 signaling in prostate cancer cells: A new vicious cycle in bone metastases (2011) (0)
- Patents And literature (1985) (0)
- Role of Autocrine Motility in Osteolytic Metastasis (2000) (0)
- Characterization of the depressed human insulin gene family (1984) (0)
- Role of Autocrine Motility Factor in Osteolytic Metastasis. (1999) (0)
- Tumor-Associated Osteoclastogenesis and Angiogenesis – Toshio Matsumoto and Masahiro Abe Biology and Treatment of Prostate Cancer Bone Metastasis (2010) (0)
- DNA transfer vector and recombinant microorganism containing a gene from a higher organism (1978) (0)
- Neonatal Mouse Bone Supports Growth Of Primary Myeloma Cells Ex Vivo and Assessment Of Responses To Antimyeloma Drugs (2013) (0)
- PTHrP May Contribute to Cachexia Accompanying Multiple Myeloma Bone Disease (2018) (0)
- 595: The Metastasis Suppressor Gene RhoGDI2 Reduceslung Metastasis in Human Bladder Cancer Via Downregulation of Endothelin 1 (2005) (0)
- Meeting Report from the IX International Meeting on Cancer Induced Bone Disease: October 28-31, 2009 in Arlington, Virginia, USA (2010) (0)
- Foerfarande Foer framstaellning of a recombinant DNA-molecule to som innehaoller I Foer tillvaexthormon the encoding nukleotidsekvens, and which have kan anvaendas at framstaellning of a tillvaexthormon producerande Mikroorganismen (1981) (0)
- Epitope mapping of recombinant human procathepsin D. (1998) (0)
- Crystal structure of mouse phosphoglucose isomerase in complex with erythrose 4-phosphate (2004) (0)
- Role of bone-anabolic agents in the treatment of breast cancer bone metastases (2014) (0)
- Myeloma Cells Induce High Level of TAF12 Expression in Bone Marrow Stromal Cells, Resulting in Increased Osteoclastogenesis and Myeloma Cell Growth in Response to 1,25(OH) 2 D 3 (2016) (0)
- DNA transfer vector for transformation of a microorganism (1978) (0)
- P16. Hypoxia and breast cancer bone metastasis: HIF-1α enhances TGF-β signaling and expression of prometastatic factors CXCR4 and VEGF (2008) (0)
- CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLUCOSE ISOMERASE/NEUROLEUKIN/AUTOCRINE MOTILITY FACTOR/MATURATION FACTOR (2001) (0)
- TAF12 Enhances the Biological Reponses of Myeloma Cells to Low Concentrations of 1,25-(OH)2dvitamin D3 (2014) (0)
- Skeletal Complications of Malignancy: Central Role for the Osteoclast (2005) (0)
- Halofuginone reduces bone metastases: TGF-β-dependent and independent effects (2011) (0)
- Expression of chimeric human aspartic proteinases. (1998) (0)
- IMMUNOHISTOCHEMISTRY EXPRESSION OF KLOTHO IN BONE MARROW BIOPSIES FROM NORMAL, MGUS, AND PLASMA CELL MYELOMA (2012) (0)
- Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors (2019) (0)
- The Increased 1,25-(OH)2D3 Sensitivity of Myeloma Cells and Marrow Stromal Cells Enhances RANKL Production and Tumor Cell Growth (2012) (0)
- P32. Transforming growth factor-β (TGF-β) promotes prostate cancer bone metastases: Increased expression of pro-osteolytic genes and of PMEPA1, a new TGF-β signalling regulator (2008) (0)
- PSA Converts Parathyroid Hormone-Related Protein (THrP) from an Osteolytic to an Osteoblastic Factor: Role in Bone Metastasis (2004) (0)
- Dns-transfer-vector and a gen a higher organism containing microorganism (1978) (0)
- Targeted Antibody Inhibition of Bone Metastases by Prostate Cancer (2000) (0)
- Tumor-Secreted Autocrine Motility Factor (AMF): Causal Role in an Animal (2005) (0)
- ASBMR 30th Annual Meeting SA001–SA572 (2011) (0)
- Central Role for the Osteoclast (2005) (0)
- Aspartic Proteinases; Retroviral and Cellular Enzymes. Advances in Experimental Biology and Medicine 436 Edited by M. N. G. James (University of Alberta). Plenum Press: New York. 1998. $139.50. xvii + 499 pp. ISBN 0-306-45809-8. (1999) (0)
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