James Merritt Downey
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(Suggest an Edit or Addition)James Merritt Downey's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Protection Against Infarction Afforded by Preconditioning is Mediated by A1 Adenosine Receptors in Rabbit Heart (1991) (1468)
- Preconditioning the myocardium: from cellular physiology to clinical cardiology. (2003) (1105)
- Opening of Mitochondrial KATP Channels Triggers the Preconditioned State by Generating Free Radicals (2000) (714)
- Preconditioning protects ischemic rabbit heart by protein kinase C activation. (1994) (689)
- Xanthine oxidase as a source of free radical damage in myocardial ischemia. (1985) (686)
- Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. (2004) (542)
- Ischemic preconditioning: from adenosine receptor to KATP channel. (2000) (527)
- Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. (1997) (526)
- Intravenous Pretreatment With A1‐Selective Adenosine Analogues Protects the Heart Against Infarction (1992) (515)
- Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. (1995) (450)
- Ischemic preconditioning protects against infarction in rat heart. (1992) (393)
- Inhibition of Coronary Blood Flow by a Vascular Waterfall Mechanism (1975) (363)
- Volatile Anesthetics Protect the Ischemic Rabbit Myocardium from Infarction (1997) (354)
- Preconditioning Causes Improved Wall Motion as Well as Smaller Infarcts After Transient Coronary Occlusion in Rabbits (1991) (348)
- Acetylcholine, Bradykinin, Opioids, and Phenylephrine, but not Adenosine, Trigger Preconditioning by Generating Free Radicals and Opening Mitochondrial KATP Channels (2001) (333)
- Signaling pathways in ischemic preconditioning (2007) (331)
- Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium. (1994) (327)
- Preconditioning: state of the art myocardial protection. (1993) (320)
- Protein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria (2005) (305)
- The pH Hypothesis of Postconditioning: Staccato Reperfusion Reintroduces Oxygen and Perpetuates Myocardial Acidosis (2007) (304)
- Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart. (1997) (295)
- Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart. (1994) (292)
- Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. (2004) (289)
- Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. (2006) (279)
- Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery (2016) (264)
- alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. (1994) (261)
- Protein Kinase C- ξ is Responsible for the Protection of Preconditioning in Rabbit Cardiomyocytes (1999) (258)
- Signal Transduction in Ischemic Preconditioning: (1999) (251)
- Postconditioning’s protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3–kinase and guanylyl cyclase activation (2004) (250)
- Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations (2010) (246)
- New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. (2011) (226)
- Adenosine: trigger and mediator of cardioprotection (2008) (217)
- Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing. (1994) (211)
- Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts. (1987) (207)
- Mitochondrial K(ATP) channels: role in cardioprotection. (2002) (206)
- Mechanism of Cardioprotection by Early Ischemic Preconditioning (2010) (205)
- Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart (2017) (197)
- Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G-protein mechanism. (1993) (191)
- Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. (1995) (190)
- Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. (1990) (180)
- Adenosine and the anti-infarct effects of preconditioning. (1993) (178)
- Xanthine oxidase: a critical mediator of myocardial injury during ischemia and reperfusion? (1986) (178)
- Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning. (1994) (177)
- Signal transduction in ischemic preconditioning. (2001) (176)
- Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning. (2000) (173)
- Protein tyrosine kinase is downstream of protein kinase C for ischemic preconditioning's anti-infarct effect in the rabbit heart. (1998) (173)
- Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. (1994) (172)
- Ischemic preconditioning: from basic mechanisms to clinical applications. (2000) (169)
- NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. (2004) (168)
- Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts. (1993) (167)
- Cardioprotection by Cu,Zn-superoxide dismutase is lost at high doses in the reoxygenated heart. (1990) (162)
- Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. (2006) (161)
- Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits (1998) (157)
- Streptozotocin-induced non-insulin-dependent diabetes protects the heart from infarction. (1993) (153)
- Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton. (1999) (151)
- ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. (2002) (149)
- Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK. (2000) (146)
- Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells (2002) (145)
- Why do we still not have cardioprotective drugs? (2009) (145)
- Distribution of the Coronary Blood Flow across the Canine Heart Wall during Systole (1974) (145)
- Platelet P2Y12 Blockers Confer Direct Postconditioning-Like Protection in Reperfused Rabbit Hearts (2013) (143)
- Myocardial protection by insulin is dependent on phospatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart (1999) (142)
- cGMP signalling in pre- and post-conditioning: the role of mitochondria. (2008) (139)
- Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies. (2006) (139)
- Mild Hypothermia reduces infarct size in the beating rabbit heart: A practical intervention for acute myocardial infarction? (1998) (137)
- The effects of nitroglycerin on coronary collaterals and myocardial contractility. (1973) (134)
- Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion. (2007) (131)
- Cellular Mechanisms in Ischemic Preconditioning: The Role of Adenosine and Protein Kinase C a (1994) (130)
- Infarct limitation of the second window of protection in a conscious rabbit model. (1996) (126)
- Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning’s success (2008) (120)
- Ischemic preconditioning Nature's own cardioprotective intervention. (1992) (118)
- Protection from postconditioning depends on the number of short ischemic insults in anesthetized pigs (2006) (117)
- Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function (2018) (114)
- Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase. (2002) (112)
- Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts (2006) (112)
- Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. (2017) (111)
- Catecholamines can induce adenosine receptor-mediated protection of the myocardium but do not participate in ischemic preconditioning in the rabbit. (1993) (106)
- Myocardial contractile force as a function of coronary blood flow. (1976) (104)
- Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil. (1995) (102)
- The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart. (1994) (102)
- Ischemic postconditioning: from receptor to end-effector. (2011) (101)
- The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart. (2002) (101)
- Estimation of effective pulmonary capillary pressure in intact lungs. (1983) (101)
- Phospholipase D plays a role in ischemic preconditioning in rabbit heart. (1996) (100)
- Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia. (1998) (99)
- Hyperbaric Oxygen Limits Infarct Size in Ischemic Rabbit Myocardium In Vivo (1993) (97)
- Nitroglycerin and heterogeneity of myocardial blood flow. Reduced subendocardial blood flow and ventricular contractile force. (1973) (97)
- Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes. (1999) (96)
- Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart. (1996) (96)
- Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. (2004) (96)
- Guidelines for evaluating myocardial cell death. (2019) (94)
- Circulating blood cells and extracellular vesicles in acute cardioprotection. (2018) (93)
- Signalling pathways and mechanisms of protection in pre‐ and postconditioning: historical perspective and lessons for the future (2015) (93)
- Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism. (2004) (92)
- Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation. (1993) (91)
- Protection of ischemic preconditioning is dependent upon a critical timing sequence of protein kinase C activation. (1997) (89)
- Mitochondrial KATP channels in preconditioning (2003) (89)
- Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium. (1994) (87)
- Signal transduction of ischemic preconditioning. (1997) (86)
- Innate immunity as a target for acute cardioprotection. (2019) (86)
- Protection from reperfusion injury by preconditioning hearts does not involve increased antioxidant defenses. (1992) (85)
- Effects of Myocardial Strains on Coronary Blood Flow (1974) (84)
- Signal transduction in ischemic preconditioning. (1995) (83)
- Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia. (1998) (81)
- Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase. (2003) (81)
- 9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection (2016) (80)
- The small chill: mild hypothermia for cardioprotection? (2010) (78)
- Myocardial protection with mild hypothermia. (2012) (78)
- Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits. (1995) (78)
- Magnesium deficiency and myocardial infarct size in the dog. (1985) (77)
- Progression of myocardial infarction in a collateral flow deficient species. (1989) (77)
- Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF. (2004) (75)
- Tetrazolium artifactually indicates superoxide dismutase-induced salvage in reperfused rabbit heart. (1989) (73)
- Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening. (2003) (72)
- Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease. (1996) (72)
- Limitation of infarct size in rabbit hearts by the novel adenosine receptor agonist AMP 579 administered at reperfusion. (2000) (70)
- Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction. (2009) (70)
- AMP 579 Reduces Contracture and Limits Infarction in Rabbit Heart by Activating Adenosine A2 Receptors (2001) (66)
- SB 203580, an inhibitor of p38 MAPK, abolishes infarct-limiting effect of ischemic preconditioning in isolated rabbit hearts (2000) (66)
- Pulmonary capillary pressure: A review (1992) (65)
- Determinants of infarct size during permanent occlusion of a coronary artery in the closed chest dog. (1987) (65)
- Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart (2013) (64)
- Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator (2007) (64)
- Total liquid ventilation provides ultra-fast cardioprotective cooling. (2007) (64)
- Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C. (2008) (64)
- Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways. (2007) (63)
- Reactive Oxygen Species as Intracellular Signaling Molecules in the Cardiovascular System (2018) (63)
- Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits. (1993) (63)
- Mapping Preconditioning's Signaling Pathways (2008) (62)
- Adenosine A1 Agonist at Reperfusion Trial (AART): Results of a Three-Center, Blinded, Randomized, Controlled Experimental Infarct Study (2000) (62)
- Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts. (2010) (61)
- Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning (2008) (60)
- Hypoxia preconditions rabbit myocardium via adenosine and catecholamine release. (1995) (60)
- Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity (2011) (60)
- Favorable remodeling enhances recovery of regional myocardial function in the weeks after infarction in ischemically preconditioned hearts. (2000) (59)
- Adenosine-induced vasodilation: receptor characterization in pulmonary circulation. (1995) (58)
- NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase (2006) (58)
- Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart. (1999) (56)
- Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion (2015) (56)
- We think we see a pattern emerging here. (2005) (55)
- Reducing infarct size in the setting of acute myocardial infarction. (2006) (55)
- P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. (2003) (55)
- The Role of Vascular Capacitance in the Coronary Arteries (1984) (54)
- Cardioprotective PKG-independent NO signaling at reperfusion. (2010) (54)
- Two Classes of Anti-Platelet Drugs Reduce Anatomical Infarct Size in Monkey Hearts (2013) (53)
- Acute ethanol exposure fails to elicit preconditioning-like protection in in situ rabbit hearts because of its continued presence during ischemia. (2001) (53)
- Electrophysiological characteristics of repetitive ischemic preconditioning in the pig heart. (1996) (53)
- Can beta blockers limit myocardial infarct size? (1986) (52)
- Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning. (1993) (52)
- Xanthine oxidase contributes to preconditioning's preservation of left ventricular developed pressure in isolated rat heart: developed pressure may not be an appropriate end-point for studies of preconditioning (2002) (51)
- BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts. (2009) (50)
- New and revisited approaches to preserving the reperfused myocardium (2017) (49)
- Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein. (1993) (49)
- Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton. (1999) (49)
- Myocardial stunning in dogs: preconditioning effect and influence of coronary collateral flow. (1990) (48)
- Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals. (2003) (47)
- Making the heart resistant to infarction: how can we further decrease infarct size? (2008) (47)
- Attenuated purine production during subsequent ischemia in preconditioned rabbit myocardium is unrelated to the mechanism of protection. (1996) (46)
- Comparison of in vitro preconditioning responses of isolated pig and rabbit cardiomyocytes: effects of a protein phosphatase inhibitor, fostriecin. (1997) (45)
- Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart. (1999) (44)
- Acute alcohol-induced protection against infarction in rabbit hearts: differences from and similarities to ischemic preconditioning. (2001) (44)
- Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart. (1993) (43)
- Acadesine extends the window of protection afforded by ischaemic preconditioning. (1994) (42)
- The impact of irreproducibility and competing protection from P2Y12 antagonists on the discovery of cardioprotective interventions (2017) (42)
- Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. (2006) (42)
- Mechanisms of acetylcholine- and bradykinin-induced preconditioning. (2005) (41)
- The PKC activator PMA preconditions rabbit heart in the presence of adenosine receptor blockade: is 5'-nucleotidase important? (1998) (40)
- Combined Cardioprotectant and Antithrombotic Actions of Platelet P2Y12 Receptor Antagonists in Acute Coronary Syndrome (2014) (39)
- Cardioprotection With Adenosine A2 Receptor Activation at Reperfusion (2005) (38)
- Timing and duration of administration are crucial for antiinfarct effect of AMP 579 infused at reperfusion in rabbit heart. (2003) (38)
- The Highly Selective Caspase-1 Inhibitor VX-765 Provides Additive Protection Against Myocardial Infarction in Rat Hearts When Combined With a Platelet Inhibitor (2017) (37)
- Is It Time to Translate Ischemic Preconditioning’s Mechanism of Cardioprotection into Clinical Practice? (2011) (37)
- S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning. (1999) (37)
- Chelerythrine, a highly selective protein kinase C inhibitor, blocks the antiinfarct effect of ischemic preconditioning in rabbit hearts (1994) (37)
- Adenosine and A1 selective agonists offer minimal protection against ischaemic injury to isolated rat cardiomyocytes. (1993) (37)
- Menadione mimics the infarct-limiting effect of preconditioning in isolated rat hearts. (2001) (37)
- Quantitative study of intramyocardial compression in the fibrillating heart. (1979) (37)
- Cardioprotection: spotlight on PKG (2007) (36)
- The protection of ischaemic preconditioning can be reinstated in the rabbit heart after the initial protection has waned. (1993) (36)
- Mitochondrial K(ATP) channels in preconditioning. (2003) (36)
- Adenosine is an endogenous protectant against stunning during repetitive ischemic episodes in the heart. (1992) (35)
- What is Wrong With Cardiac Conditioning? We May be Shooting at Moving Targets (2015) (35)
- Attenuation of infarction in cynomolgus monkeys: preconditioning and postconditioning (2009) (35)
- The active and passive components of extravascular coronary resistance. (1975) (34)
- Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart. (2005) (34)
- CGX-1051, A Peptide from Conus Snail Venom, Attenuates Infarction in Rabbit Hearts When Administered at Reperfusion (2003) (33)
- Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists (2016) (33)
- Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation (2016) (32)
- Do mitochondrial KATP channels serve as triggers rather than end-effectors of ischemic preconditioning's protection? (2000) (32)
- Localizing extracellular signal–regulated kinase (ERK) in pharmacological preconditioning's trigger pathway (2006) (32)
- Cardioprotective Properties of the Platelet P2Y12 Receptor Inhibitor, Cangrelor: Protective in Diabetics and Reliant Upon the Presence of Blood (2015) (31)
- A really radical observation (2006) (31)
- Effect of superoxide dismutase plus catalase on myocardial infarct size in rabbits. (1988) (31)
- Protecting the acutely ischemic myocardium beyond reperfusion therapies: are we any closer to realizing the dream of infarct size elimination? (2007) (31)
- A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin (2011) (31)
- Cyclooxygenase products are not involved in the protection against myocardial infarction afforded by preconditioning in rabbit. Cyclooxygenase pathway's involvement in preconditioning. (1992) (30)
- Compression of the Coronary Arteries by the Fibrillating Canine Heart (1976) (30)
- Failure of N-2-mercaptopropionyl glycine to reduce myocardial infarction after 3 days of reperfusion in rabbits (1999) (30)
- Limitation of infarct size for 24 hours by combined treatment with allopurinol plus verapamil during acute myocardial infarction in the dog. (1987) (30)
- Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes (2011) (29)
- Current research views on myocardial reperfusion and reperfusion injury. (1990) (29)
- Determination of Coronary Collateral Flow by a Load Line Analysis (1982) (29)
- A really radical observation--a comment on Penna et al. in Basic Res Cardiol (2006) 101:180-189. (2006) (29)
- Inhibitory effect of cardiac contraction on coronary collateral blood flow. (1977) (29)
- A new animal model of controlled coronary artery occlusion in conscious rabbits. (1994) (29)
- Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop (2012) (29)
- Adenosine and the Antiinfarct Effects of Preconditioning (1994) (29)
- Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes. (1997) (28)
- Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart. (1999) (28)
- Superoxide dismutase conjugated to polyethylene glycol fails to limit myocardial infarct size after 30 min ischemia followed by 72 h of reperfusion in the rabbit. (1991) (28)
- No confirmation for a causal role of volume-regulated chloride channels in ischemic preconditioning in rabbits. (2000) (28)
- Protection From AMP 579 Can Be Added to That From Either Cariporide or Ischemic Preconditioning in Ischemic Rabbit Heart (2002) (27)
- The Role of Protein Kinase C in Ischemic Preconditioning (1996) (26)
- Cellular mechanisms in ischemic preconditioning: the role of adenosine and protein kinase C. (1994) (26)
- Barium contracture: a model for systole. (1980) (26)
- Selective coronary embolization in closed-chest dogs. (1977) (26)
- An explanation for the reported observation that ATP dependent potassium channel openers mimic preconditioning. (1993) (25)
- Pressure-flow characteristics and nutritional capacity of coronary veins in dogs. (1988) (25)
- Subendocardial coronary compression in beating dog hearts is independent of pressure in the ventricular lumen. (1991) (25)
- Discrepancy between microsphere and diffusible tracer estimates of perfusion to ischemic myocardium. (1985) (24)
- Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists (2016) (24)
- Endogenous myocardial norepinephrine is not essential for ischemic preconditioning in rabbit heart. (1996) (24)
- What Is the Optimal Postconditioning Algorithm? (2009) (23)
- Second window of protection against infarction in conscious rabbits: real or artifactual. (1999) (23)
- Preconditioning one myocardial region does not neccessarily precondition the whole rabbit heart (2002) (22)
- Mitochondria and their role in preconditioning's trigger phase (2003) (22)
- Protection afforded by allopurinol in the first 24 hours of coronary occlusion is diminished after 48 hours. (1988) (22)
- Hydrogen peroxide as a protective agent during reperfusion. A study in the isolated perfused rabbit heart subjected to regional ischemia. (1995) (22)
- Collateral blood flow in segmental intestinal ischemia: effects of vasoactive agents. (1986) (22)
- A2b adenosine receptors can change their spots (2010) (22)
- Intravenous co-infusion of adenosine and norepinephrine preconditions the heart without adverse hemodynamic effects. (1997) (22)
- The Protective and Anti‐Protective Effects of Ethanol in a Myocardial Infarct Model (2002) (22)
- Transient inhibition of glucose uptake mimics ischemic preconditioning by salvaging ischemic myocardium in the rabbit heart. (1995) (21)
- Nicorandil opens mitochondrial KATP channels not only directly but also through a NO-PKG-dependent pathway (2006) (21)
- Attenuation of oxidant stress during reoxygenation by AMP 579 in cardiomyocytes. (2001) (20)
- Chronic whole body sympathectomy fails to protect ischemic rabbit hearts. (1989) (20)
- Loss of myocardial protection from ischemic preconditioning following chronic exposure to R(-)-N6-(2-phenylisopropyl)adenosine is related to defect at the adenosine A1 receptor (1998) (19)
- Spotlight on preconditioning. (2002) (19)
- S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning. (1999) (18)
- Mitochondrial K(ATP)channel opening during index ischemia and following myocardial reperfusion in ischemic rat hearts. (2001) (18)
- Left ventricular unloading during reperfusion does not limit myocardial infarct size. (1990) (18)
- Attenuation of S-T Segment elevation during repetitive coronary occlusions truly reflects the protection of Ischemic preconditioning and is not an epiphenomenon (1997) (18)
- Arguments in favor of protein kinase C playing an important role in ischemic preconditioning (1997) (18)
- Lack of a direct metabolic effect of fructose, 1,6-diphosphate in ischemic myocardium. (1981) (17)
- Ischaemic preconditioning is not dependent on neutrophils or glycolytic substrate at reperfusion in rabbit heart. (1992) (17)
- Unraveling the mysteries of classical preconditioning. (2005) (16)
- A Review of Humoral Factors in Remote Preconditioning of the Heart (2019) (16)
- Protective and anti-protective effects of acute ethanol exposure in myocardial ischemia/reperfusion. (2004) (16)
- AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts (2009) (15)
- Inability of metoprolol to achieve a sustained limitation of infarct size 24 h after coronary artery embolization in the closed chest dog. (1984) (15)
- Direct metabolic effects of isoproterenol and propranolol in ischemic myocardium of the dog. (1980) (15)
- An irreversible A1-selective adenosine agonist preconditions rabbit heart. (1996) (15)
- Dobutamine modifies myocardial infarct size through supply-demand balance. (1988) (14)
- Characterization of segmental collateral blood flow in the small intestine. (1985) (14)
- The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart (1997) (14)
- All Preconditioning-Related G Protein-Coupled Receptors Can Be Demonstrated in the Rabbit Cardiomyocyte (2012) (13)
- Free radicals in the heart: friend or foe? (2008) (13)
- Loss of glycogen during preconditioning is not a prerequisite for protection of the rabbit heart (1996) (13)
- Contribution of myocardial contractility to myocardial perfusion. (1979) (13)
- Does mild hypothermia protect against reperfusion injury? The debate continues (2011) (13)
- Examination of Two Small‐Molecule Antiperoxidative Agents in a Rabbit Model of Postischemic Myocardial Infarction (1991) (13)
- Prediction of regional myocardial blood flow in dogs. (1980) (12)
- Dose-response relationships of the protective and antiprotective effects of acute ethanol exposure in isolated rabbit hearts. (2002) (12)
- Hypoxia preconditions rabbit myocardium by an adenosine receptor-mediated mechanism. (1995) (12)
- CHAPTER 50 – Ischemic Preconditioning: Description, Mechanism, and Significance (2001) (12)
- Activation of Protein Kinase C is Critical to the Protection of Preconditioning (1996) (12)
- Experimental models assessing the physiology of myocardial ischemia (1993) (12)
- CHAPTER 1 – Sequence of Cardiac Activation and Ventricular Mechanics (2001) (12)
- The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart (2021) (12)
- Extravascular Coronary Resistance (1989) (11)
- Melatonin as a cardioprotective therapy following ST-segment elevation myocardial infarction: is it really promising? Reply. (2017) (11)
- An evaluation of the coronary constriction following propranolol. (1977) (11)
- Ischemic Preconditioning of Myocardium: Effect of Adenosine (1993) (11)
- AMISTAD trials: possible reasons for lack of success. (2006) (11)
- Free-radical scavengers preserve wall motion in the xanthine oxidase-deficient rabbit heart (1990) (10)
- The Effect of Cardiac Contraction on Collateral Resistance in the Canine Heart (1976) (10)
- The Transmural Distribution of Coronary Blood Flow During Maximal Vasodilation 1 (1975) (10)
- Adenosine at reperfusion: a conundrum ready to be resolved. (2009) (10)
- Mast cell degranulation does not contribute to ischemic preconditioning in isolated rabbit hearts (1996) (10)
- Adenosine and Opioid Receptors Do Not Trigger the Cardioprotective Effect of Mild Hypothermia (2012) (9)
- Ticagrelor Does Not Protect Isolated Rat Hearts, Thus Clouding Its Proposed Cardioprotective Role Through ENT 1 in Heart Tissue (2019) (9)
- Autoradiographic evaluation of myocardial collateral circulation in the canine heart. (1973) (8)
- Protection by ischaemic preconditioning appears independent of stress protein synthesis (1991) (8)
- Ischemic preconditioning through opening of swelling-activated chloride channels? (2001) (8)
- Ventricular arrhythmias produced by coronary artery occlusion in closed-chest dogs (1978) (8)
- Oxypurinol limits myocardial infarct size in closed chest dogs without pretreatment. (1990) (7)
- Preconditioning: Markers vs. epiphenomena (1996) (7)
- Preconditioning : what it is and how it works (2004) (7)
- Myocardial salvage with allopurinol during 24 h of permanent coronary occlusion: importance of pretreatment. (1988) (7)
- Enhancement of myocardial contractility by dilatation of coronary collaterals (1973) (6)
- Verapamil and nifedipine limit infarct size in the dog. (1983) (6)
- Status of P2Y12 treatment must be considered in evaluation of myocardial ischaemia/reperfusion injury. (2015) (6)
- What Are Optimal P2Y12 Inhibitor and Schedule of Administration in Patients With Acute Coronary Syndrome? (2020) (6)
- Relationship between incidence of early ventricular arrhythmias, ischemic zone size, and coronary collateral flow in the dog. (1986) (6)
- Acetylcholine leads to free radical production dependent on KATP channels, G1 proteins, phosphatidylinositol 3-, and tyrosine kinases (2002) (5)
- Diltiazem reduced infarct size but not ventricular arrhythmias in 48 hour coronary embolized dogs. (1985) (5)
- Bypassing big pharma. (2007) (5)
- Nifedipine limits infarct size for 24 hours in closed chest coronary embolized dogs (2005) (5)
- Long acting calcium antagonist anipamil limits myocardial necrosis and penetrates the ischemic zone during 24 h of coronary artery occlusion in the dog. (1990) (5)
- The Role of Adenosine in Ischemic Preconditioning (1994) (5)
- Pressure-flow characteristics of coronary collaterals in dogs. (1990) (5)
- Animal models for the study of myocardial protection against ischemia (2005) (4)
- O-linked beta-N-acetylglucosamine: a new piece of the cardioprotection puzzle? (2008) (4)
- Protein Kinase C - the Key-Enzyme in Ischemic Preconditioning? (1997) (4)
- Abstract 217: Selective Adenosine A2b Receptor Activation Mimics Postconditioning in a Rabbit Infarct Model (2006) (4)
- Letter by Downey and Cohen Regarding Article, "Protective Effects of Ticagrelor on Myocardial Injury After Infarction". (2017) (4)
- The Extravascular Resistance (1987) (4)
- The inability of isoproterenol or propranolol to alter the lateral dimensions of experimentally induced myocardial infarcts (1982) (4)
- Oxygen-Derived Free Radicals and Myocardial Injury: A Critical Role for Xanthine Oxidase?1 (1986) (4)
- The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart. (2020) (4)
- Down-Regulation of Replication Factor C-40 (RFC40) Causes Chromosomal Missegregation in Neonatal and Hypertrophic Adult Rat Cardiac Myocytes (2012) (4)
- Hatter Institute Workshop on Myocardial Preconditioning, Cape Town, April 1998 (1998) (3)
- Comments on flow through collapsible tubes at low Reynolds numbers. (1981) (3)
- Reduced subendocardial blood flow and ventricular contractile force caused by nitroglycerin (1972) (3)
- Myocardial salvage by pharmacological interventions (1984) (3)
- Preconditioning protects against myocardial infarction equally well with pyruvate or glucose containing reperfusate (1992) (3)
- BAY 58-2667, an NO-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts (2009) (3)
- INHALATIONAL ANESTHESIA PROTECTS THE ISCHEMIC MYOCARDIUM FROM INFARCTION (1994) (3)
- Swelling-activated chloride channels as effectors of ischemic preconditioning? (2001) (3)
- Anipamil limits myocardial necrosis in the closed chest dog doring 24 hours of coronary artery occlusion (1986) (3)
- Which preconditioning‐associated G protein‐coupled receptors are expressed on the sarcolemma? (2009) (3)
- Determination of coronary collateral flow by a load line analysis. (1982) (3)
- A functional estimate of overlap between adjacent coronary circulations in the dog (1986) (2)
- [Delta-opioid receptor agonists prevent the irreversible damage of cardiomyocytes in ischemized-reperfused isolated rat heart]. (2004) (2)
- M itochondrial K channels: role in cardioprotection (2002) (2)
- Role of Adenosine in the Phenomenon of Ischemic Preconditioning (1995) (2)
- 6. Protein IGnase C - the I(ey-Enzyme in Ischemic Preconditioning? (1997) (2)
- Xanthine Oxidase is not Likely to be a Source of Injurious Free Radicals in the Ischemic Human Heart: A Study of Species Differences (1988) (2)
- The warm-up phenomenon and ischaemic preconditioning: an uncertain relationship. (1999) (2)
- Do Adenosine A3 Receptors Cause Preconditioning (1996) (2)
- CHAPTER 4 – Control of Cardiac Output and Its Alterations during Exercise and in Heart Failure (2001) (2)
- Oestrogen plays a permissive role in cardioprotection. (2008) (2)
- The Determinants of The Intramyocardial Distribution of The Coronary Blood Flow (1971) (2)
- Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor (2016) (2)
- Pathophysiology of Myocardial Reperfusion Injury (2012) (2)
- The failure of hydrogen peroxide to improve function in ischemically depressed myocardium. (1979) (2)
- Abstract 12246: Is Mitochondrial DNA Fragmentation a Major Contributor to Necrosis in Myocardial Infarction? (2014) (1)
- Protective and anti-protective effects of acute ethanol exposure have similar thresholds in isolated rabbit hearts (2001) (1)
- Acadesine potentiates the cardioprotective effects of ischemic preconditioning in rabbits (1992) (1)
- Abstract 10281: Cangrelor’s Anti-Infarct Effect Requires Phosphorylation of Sphingosine in Platelets: The Missing Link (2015) (1)
- HEART NEWS AND VIEWS The News Bulletin of the International Society for Heart Research (2000) (1)
- Collateral perfusion of ischemic myocardium is inversely related to the size of the ischemic zone (1988) (1)
- Factors influencing infarct size: Is coronary collateral flow the key determinant? (1986) (1)
- Failure of metoprolol to limit myocardial infarct size during 24 hours of coronary artery occlusion in a closed chest dog (1984) (1)
- Critical collateral bloodflow level for salvage of ischemic myocardium. (1989) (1)
- Acetylcholine-induced production of reactive oxygen species in adult rabbit myocytes is dependent on phosphatidylinositol 3-kinase activation and mitochondrial KATP channel opening (2002) (1)
- [Retrograde blood flow]. (1985) (1)
- The effect of combination therapy on infarct size limitation in the dog (1985) (1)
- Feasibility of using thermal response to Ka band millimeter wave heating to assess skin blood flow (2018) (1)
- Myocardial infarct size limitation. Principles, problems and possibilities. (1984) (1)
- Remote Ischemic Conditioning: more explanations and more expectations (2022) (1)
- 1 – Regulation of Myocardial Contractility (1981) (1)
- Mitochondria and Their Role in Ischemia/Reperfusion Injury (2007) (1)
- Adenosine A2b receptors unexpectedly activate cardioprotective kinases through Gi rather than Gs (2009) (1)
- Effects of anesthesia and K+ ATP channel blockade on interstitial adenosine accumulation in ischemic rabbit myocardium (1995) (1)
- Acetylcholine, but not adenosine, triggers cardiac preconditioning by causing release of free radicals and opening of mitochondrial KATP channels (2000) (1)
- Ischaemia-Reperfusion Injury; Current Research Status (1988) (1)
- Modulation of receptor sensitivity: possible therapeutic target? (2009) (1)
- Inability of chronic chemical sympathectomy to induce coronary collateral growth or development: studies in the rat heart in vivo. (1989) (1)
- Augmented taurine release is not the mechanism of ischemic preconditioning’s cardioprotection (2004) (1)
- EFFECTS OF ANESTHETIC AGENTS AND HEART RATE ON RISK OF INFARCTION IN ISCHEMIC RABBIT MYOCARDIUM (1992) (1)
- IS066 Keynote Lecture : Ischemic Presonditioning and Cardioprotection : Mechanisms by Which Early (First Window) and Late (Second Window) Phases of Protection are Induced (2000) (0)
- Mitochondrial K+ influx per se causes generation of reactive oxygen species in vascular smooth muscle cells (2001) (0)
- The Role of mK_ channels in Ischemic Preconditioning (2002) (0)
- APPARENT PROTECTION AFFORDED BY ALLOPURINOL IN THE 1ST 24 HOURS OF PERMANENT CORONARY-OCCLUSION IS DIMINISHED AFTER 48 HOURS (1987) (0)
- The Feasibility of Using Millimeter Wave Heating for Non-Invasive Measurement of Skin Blood Flow in Humans (2013) (0)
- Abstract 13478: Does Blockade of Platelet Aggregation after Stenting for STEMI Protect Against Reperfusion Injury? (2011) (0)
- A83. PMA administered just before reperfusion salvages ischemic myocardium by an adenosine A2b-dependent mechanism (2006) (0)
- Brief Exposure to Intracoronary Bradykinin at Reperfusion Limits Infarct Size in Isolated Rabbit Hearts by a Mechanism That Involves Both Free Radical Production and PKC (2008) (0)
- Adenosine A1 receptors mediate preconditioning (1992) (0)
- AMP579 binds to adenosine A2b receptors thus resolving longstanding mystery of its cardioprotective signaling (2009) (0)
- 14 – Evaluation of Drug Effects on Coronary Blood Flow and Cardiac Oxygen Consumption (1981) (0)
- PKC enhances adenosine A2b receptor sensitivity in preconditioned rabbit hearts (2007) (0)
- Abstract 410: Ultrafast Cooling Initiated By A Short And Safe Temperature-controlled Liquid Ventilation Abolishes Post-ischemic Myocardial Infarction And Contractile Dysfunction In Chronically Instrumented Rabbits (2007) (0)
- Postconditioning protects by maintaining acidosis during reoxygenation (2007) (0)
- President’s Page: ISHR seeks nominations for society awards to be presented in Brisbane (2003) (0)
- Workshop : Cardioprotection – from novel targets to clinical application (2016) (0)
- Delineating coronary hemodynamic mechanisms by computer simulation (1987) (0)
- Cardioprotective role of A1 receptor ligands (1992) (0)
- 02 The potassium ionophore valinomycin mimics preconditioning and generates reactive oxygen species (2002) (0)
- VENOUS LEVEL COLLATERALS IN THE CORONARY SYSTEM (1992) (0)
- Rabbit ventricular myocytes can be preconditioned by activation of protein kinase C-coupled receptors (1996) (0)
- Pharmacological approaches to infarct size limitation (1986) (0)
- Book Reviews; Coronary Blood Flow. (1992) (0)
- 14 NECA limits infarction in rabbit heart by activating adenosine A2 receptor and PI3-kinase (2002) (0)
- IL-1 Basic mechanisms of preconditioning (2002) (0)
- Abstract 845: Cardioprotection From GSK-3{beta} Inhibition Requires Activation of PI-3 Kinase and Src but not Akt, PKC, or ERK (2007) (0)
- The role of animal experimentation in cardivascular therapeutic discovery. Commentary (1994) (0)
- cific enhancer controls the expression of vation by MyoD (2003) (0)
- M itochondrial K channels : role in cardioprotectionATP (2002) (0)
- A2B or not 2B: that is the question (2012) (0)
- 28 DO ADENOSINE A:J RECEPTORS CAUSE PRECONDmONING? (1995) (0)
- Erratum: Guidelines for evaluating myocardial cell death (American Journal of Physiology - Heart and Circulatory Physiology (2019) 317 (H891-H922) DOI: 10.1152/ajpheart.00259.2019) (2019) (0)
- a1-Adrenergic Agonists Precondition Rabbit Ischemic Myocardium Independent of Adenosine by Direct Activation of Protein Kinase C (2005) (0)
- The role of cGMP and PKG in cardioprotection (2009) (0)
- [ATP-dependent K+channels and the regulation of cardiac resistance to ischemic and reperfusion injuries]. (2006) (0)
- Salvage of ischemic myocardium by allopurinol: Importance of pre-treatment (1987) (0)
- A29. Nicorandil opens mitochondrial KATP channels both directly and through a NO-PKG-dependent pathway (2006) (0)
- A64. Total liquid ventilation rapidly cools the heart to protect it from infarction (2006) (0)
- 05 Acetylcholine-induced production of reactive oxygen species in A7r5 cells is dependent on protein kinase C (2002) (0)
- TOXEMIA IN THE NEW-BORN SIMULATING CEREBRAL HEMORRHAGE. (1908) (0)
- Protective effect of AMP 579 depends on drug's timing of administration and can be added to that of ischemic preconditioning (2001) (0)
- A93. Reperfusion events in the preconditioned heart (2006) (0)
- Myocardial hypothermia preserves mitochondrial and post-ischemic regional left ventricular functions in rabbits (2009) (0)
- 13 Acetylcholine activates phosphatidylinositol 3-kinase via transactivation of the EGF receptor (2002) (0)
- Abstract 1900: Preconditioning in Cynomolgus Monkey Heart Protects Against Both Ischemic and Reperfusion Injury (2008) (0)
- A ctivation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals (2003) (0)
- Acetylcholine but not adenosine triggers preconditioning by a pathway involving Src and PI3 kinases (2002) (0)
- Does combination therapy with allopurinol and verapamil limit infarct size in dogs (1986) (0)
- Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity (2023) (0)
- A133. DADLE but not bradykinin activates Src and PI3-kinase through the EGF receptor (2006) (0)
- Acetylcholine and adenosine activate phosphatidylinositol 3-kinase through transactivation of receptor tyrosine kinases in a Src-dependent manner (2002) (0)
- Inability of Left Ventricular Decompression to Limit Myocardial Infarct Size (1993) (0)
- Chapter 8 Endogenous Mechanisms of Cardioprotection (2009) (0)
- Commentaries on this month's Cardiovascular Controversy: the merits and demerits of animal experimentation From J M Downey (1994) (0)
- Regulation of basal cAMP levels in rabbit cardiomyocytes (2009) (0)
- The effect of inotropic dose of dobutamine during reperfusion on myocardial infarct size. (1989) (0)
- A cetylcholine leads to free radical production dependent on KATP channels , G proteins , phosphatidylinositol 3-kinase and tyrosinei kinase (2001) (0)
- 576 a 1-Adrenergic Agonists Precondition Rabbit Ischemic Myocardium Independent of Adenosine by Direct Activation of Protein Kinase C (2005) (0)
- Acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF to generate mitochondrial ROS (2003) (0)
- Introduction to physical signs in cardiology (1997) (0)
- CVR-2018-935R1 Title: Circulating blood cells and extracellular vesicles in acute cardioprotection Short title: Circulating cells and vesicles in cardioprotection (2019) (0)
- Response to Letter Regarding Article, “Bypassing Big Pharma” (2008) (0)
- 212 Bradykinin leads to generation of reactive oxygen species in cardiomyocytes by activation of B2-receptor and opening of mitochondrial KATP channels via PKG (2003) (0)
- ST-I-1 Adenosine receptors and cardioprotection at reperfusion (2002) (0)
- Phosphatidylinositol 3-kinase/AKT pathway contributes to ischemic preconditioning in isolated rabbit heart (2002) (0)
- 220 Bradykinin and NECA but not acetylcholine at reperfusion limit infarction in rabbit heart through activation of P13‐kinase (2003) (0)
- The percentage of the ischemic risk zone infarcting following permanent coronary occlusion is independent of ischemic zone size. (1988) (0)
- Attenuated purine release from preconditioned rabbit myocardium is unrelated to protection (1996) (0)
- Focus on the Mitochondrion Mitochondrial K ATP channels in preconditioning (2003) (0)
- Contents of Volume 101 (2006) (2006) (0)
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What Schools Are Affiliated With James Merritt Downey?
James Merritt Downey is affiliated with the following schools:
