Jeffrey m. Leiden
#164,575
Most Influential Person Now
Jeffrey m. Leiden's AcademicInfluence.com Rankings
Jeffrey m. Leidenphilosophy Degrees
Philosophy
#9627
World Rank
#13215
Historical Rank
Logic
#6594
World Rank
#8125
Historical Rank

Download Badge
Philosophy
Jeffrey m. Leiden's Degrees
- Doctorate Medicine Harvard University
- PhD Biological Chemistry University of Chicago
Why Is Jeffrey m. Leiden Influential?
(Suggest an Edit or Addition)Jeffrey m. Leiden's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. (2003) (2874)
- GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. (1997) (1102)
- CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. (1989) (683)
- Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors (1996) (677)
- Transcription factor GATA-3 is required for development of the T-cell lineage (1996) (667)
- T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. (1992) (562)
- Function of GATA transcription factors in preadipocyte-adipocyte transition. (2000) (494)
- LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. (1997) (429)
- The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. (1997) (391)
- The Ets-1 transcription factor is required for the development of natural killer cells in mice. (1998) (385)
- Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. (1995) (382)
- Expression of recombinant genes in myocardium in vivo after direct injection of DNA. (1990) (359)
- Human GATA‐3: a lineage‐restricted transcription factor that regulates the expression of the T cell receptor alpha gene. (1991) (345)
- Critical roles for transcription factor GATA-3 in thymocyte development. (2003) (337)
- Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle (2001) (336)
- Defective activation and survival of T cells lacking the Ets-1 transcription factor (1995) (335)
- Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. (1994) (311)
- Transcriptional regulation of T lymphocyte development and function. (1999) (304)
- Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. (1995) (295)
- Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. (1999) (291)
- Systemic delivery of recombinant proteins by genetically modified myoblasts. (1991) (286)
- Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. (1998) (264)
- Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB (1996) (258)
- Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins (1995) (257)
- Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. (1992) (254)
- An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis (1999) (232)
- The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB (1993) (227)
- Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc–dependent pathway (2001) (223)
- Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart (1999) (220)
- Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28 (1998) (215)
- Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (1993) (212)
- Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. (1999) (205)
- The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells (1994) (201)
- A direct physical association between ETS and AP-1 transcription factors in normal human T cells. (1995) (191)
- Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. (1990) (191)
- Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. (1996) (185)
- A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2 (2000) (178)
- p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures (1997) (173)
- Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. (1998) (159)
- Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors (1994) (155)
- Transcriptional regulation of T cell receptor genes. (1993) (153)
- Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. (1999) (150)
- Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. (2000) (150)
- Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells (1997) (147)
- The role of Ets transcription factors in the development and function of the mammalian immune system. (1997) (138)
- The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. (1994) (132)
- Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus. (1994) (127)
- CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. (1995) (125)
- Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene (1992) (121)
- A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle (1994) (120)
- The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes. (1992) (120)
- Rapid response (1998) (119)
- A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells (1992) (118)
- A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus. (1989) (115)
- Regulation of excitatory transmission at hippocampal synapses by calbindin D28k. (1995) (113)
- Evolutionary conservation of antigen recognition: the chicken T-cell receptor beta chain. (1990) (108)
- Elf-1 binds to a critical element in a second CD4 enhancer (1994) (108)
- Expression of GATA-3 During Lymphocyte Differentiation and Mouse Embryogenesis (1992) (108)
- Accuracy of echocardiographic estimates of left ventricular mass in mice. (2001) (105)
- Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. (1987) (103)
- Gene therapy--promise, pitfalls, and prognosis. (1995) (103)
- Cutting Edge: The Ets1 Transcription Factor Is Required for the Development of NK T Cells in Mice1 (2000) (100)
- Structure and expression of the murine slow/cardiac troponin C gene. (1989) (98)
- Evolutionarily conserved Ets family members display distinct DNA binding specificities [published erratum appears in J Exp Med 1993 Sep 1;178(3):1133] (1992) (97)
- Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo. (1997) (96)
- Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector. (1997) (95)
- The Gene Encoding the Mitogen-responsive Phosphoprotein Dab2 Is Differentially Regulated by GATA-6 and GATA-4 in the Visceral Endoderm* (2000) (93)
- Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes (1990) (88)
- Gene and stem cell therapies. (2001) (87)
- Structure, Function, and Regulation of Troponin C (1991) (87)
- Structure, expression and regulation of the murine 4F2 heavy chain. (1989) (84)
- Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus (1976) (79)
- Friend of GATA 2 Physically Interacts with Chicken Ovalbumin Upstream Promoter-TF2 (COUP-TF2) and COUP-TF3 and Represses COUP-TF2-dependent Activation of the Atrial Natriuretic Factor Promoter* (2001) (78)
- Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I (2000) (77)
- Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions (2001) (76)
- Characterization of murine BATF: a negative regulator of activator protein‐1 activity in the thymus (2001) (75)
- Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation (1988) (73)
- A Protein Kinase C-, Ras-, and RSK2-dependent Signal Transduction Pathway Activates the cAMP-responsive Element-binding Protein Transcription Factor following T Cell Receptor Engagement* (1998) (71)
- Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression. (1989) (69)
- Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice. (1993) (68)
- Adenovirus-Mediated Transfer of the Herpes Simplex Virus Thymidine Kinase Gene Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation Following Balloon Angioplasty of the Rat Carotid Artery (1995) (67)
- The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins (1989) (61)
- The genetics of dilated cardiomyopathy--emerging clues to the puzzle. (1997) (57)
- Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen. (1986) (57)
- Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21 (1997) (56)
- Transcriptional regulation of T-cell genes during T-cell development. (1994) (55)
- The structure and regulation of expression of the murine fast skeletal troponin C gene. Identification of a developmentally regulated, muscle-specific transcriptional enhancer. (1990) (55)
- NF-κB Is Required for the Positive Selection of CD8+ Thymocytes1 (2000) (55)
- Partial primary structure of the alpha and beta chains of human tumor T-cell receptors. (1985) (53)
- Transcriptional regulation during T-cell development: the α TCR gene as a molecular model (1992) (52)
- Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. (1986) (51)
- Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements (1990) (51)
- Adenovirus-Mediated Expression of a Ribozyme to c-mybmRNA Inhibits Smooth Muscle Cell Proliferation and Neointima Formation In Vivo (1999) (49)
- Evaluation of ventricular and arterial hemodynamics in anesthetized closed-chest mice. (1997) (45)
- Identification of a second ATF/CREB-like element in the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) promoter. (1994) (45)
- A T-cell-specific transcriptional enhancer element 3 ' of C . in the human T-cell receptor a locus (45)
- Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography. (1999) (43)
- Biocompatibility of cardiovascular gene delivery catheters with adenovirus vectors: an important determinant of the efficiency of cardiovascular gene transfer. (2000) (43)
- Muscle-based gene therapy: realistic possibilities for the future. (1996) (42)
- Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines (1980) (41)
- Recent advances in skeletal-muscle-based gene therapy. (1998) (37)
- Expression Pattern of the Ets-related Transcription Factor Elf-1 (1998) (37)
- Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms (1988) (36)
- GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer (1994) (36)
- Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule (1996) (34)
- Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes. (1989) (33)
- Human gene therapy: the good, the bad, and the ugly. (2000) (31)
- Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts. (1999) (31)
- Gene transfer into cardiac myocytes in vivo. (1991) (30)
- 17 – GATA Transcription Factors and Cardiac Development (1999) (28)
- Safe and effective regulation of hematocrit by gene gun administration of an erythropoietin-encoding DNA plasmid. (1999) (26)
- NF-kappa B is required for the positive selection of CD8+ thymocytes. (2000) (25)
- Cytotoxic T Lymphocyte Antigen 4 ( CTLA 4 ) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD 28-deficient Mice : CTLA 4 Can Function Independently of CD 28 By (1998) (25)
- Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment (1986) (25)
- A critical role for NF-kappaB transcription factors in the development of CD8+ memory-phenotype T cells. (2003) (24)
- Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset (2004) (24)
- Effects of cardiac thin filament Ca2+: statistical mechanical analysis of a troponin C site II mutant. (1996) (23)
- The Ets1 transcription factor is required for the development of NK T cells in mice. (2000) (22)
- The GATA-4 transcription factor transactivates the cardiac-specific troponin C promoter-enhancer in non-muscle cells. (1995) (19)
- Inhibition of βARK1 restores impaired biochemical β-adrenergic receptor responsiveness but does not rescue CREBA133 induced cardiomyopathy (2002) (19)
- The left ventricular stress-velocity relation in transgenic mice expressing a dominant negative CREB transgene in the heart. (2001) (17)
- The T alpha 2 nuclear protein binding site from the human T cell receptor alpha enhancer functions as both a T cell-specific transcriptional activator and repressor (1990) (17)
- Effects of exercise training on LV performance and mortality in a murine model of dilated cardiomyopathy. (2000) (15)
- Somatic gene therapy for cardiovascular disease Recent advances. (1994) (13)
- Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular model. (1992) (12)
- Cardiac Electrophysiologic Abnormalities in the CREBA133 Transgenic Mouse Model of Idiopathic Dilated Cardiomyopathy (2003) (11)
- Gene Therapy Enters Adolescence (1999) (10)
- REGULATION OF T CELL RECEPTOR GENES (1993) (9)
- Adenovirus-mediated gene transfer as an in vivo probe of lipoprotein metabolism. (1996) (9)
- LKLF and FasL expression: correctiona and clarification. (1997) (8)
- The complete primary structure of the T -Cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone (2004) (8)
- Beating the odds: a cardiomyocyte cell line at last. (1999) (7)
- Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. (2002) (7)
- In Vivo Gene Transfer into the Heart (1994) (5)
- NF-kB Is Required for the Positive Selection of CD8 Thymocytes (2000) (5)
- Canaries, coal mines and the drug supply (2008) (4)
- Polymorphic markers related to a single Tcrb-V6 gene segment (2004) (4)
- T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor α, β, or γ genes (2004) (4)
- The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells. (1989) (3)
- T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor alpha, beta, or gamma genes. (1988) (3)
- Mapping of the herpes simplex virus DNA sequences in three herpes simplex virus thymidine kinase-transformed cell lines. (1978) (3)
- Revised 3 / 23 / 00 The Gene Encoding the Mitogen-Responsive Phosphoprotein Dab 2 is Differentially Regulated by GATA-6 and GATA-4 in the Visceral Endoderm (2000) (2)
- Direct gene transfer into cardiac myocytes in vivo (1992) (2)
- DNA fragments of altered electrophoretic mobility in leukemia samples can arise from double-strand DNA breaks at nuclease hypersensitive sites of active genes. (1993) (1)
- Identification andFunctional Characterization oftheHumanT-Cell ReceptorGeneTranscriptional Enhancer: CommonNuclear Proteins Interact withtheTranscriptional Regulatory Elements oftheT-Cell Receptor oxand Genes (1990) (1)
- The Presence and Expression of Herpes Simplex Virus DNA in Transformed Cells (1978) (1)
- Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell y chain (2003) (1)
- 07 Depressed cross-bridge kinetics in dominant-negative CREB133 transgenic mouse model of dilated cardiomyopathy (2002) (0)
- Gene therapy for vascular proliferative disorders. (1996) (0)
- Erratum (2021) (0)
- 7.4-02 Identification and characterization of a human T-cell receptor β chain transcriptional element (1989) (0)
- Molecular cloning of a complementary dna encoding the heavy chain of the 4f2 cell surface antigen (1987) (0)
- In vivo studies of transcriptional regulation in cardiac myocytes using direct gene transfer into myocardium (1992) (0)
- Mapping of the HSV sequences in transformed cells (1981) (0)
- Viral IL-10 Gene Transfer Inhibition of Collagen-Induced Arthritis in Mice (1998) (0)
- Gene therapy for cardiovascular disease: Promises, pitfalls and prognosis (1999) (0)
- Elf-1 Binds to a Critical Element in a Second CD4 Enhancer (1994) (0)
- Direct Injection of DNA (2005) (0)
- Erratum (1967) (0)
- Abstracts of papers presented at the 2000 Meeting on Gene Therapy, September 25-September 29, 2000 (2000) (0)
- Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector ( gene therapy / anemia / skeletal muscle / serum protein ) (2005) (0)
- Is Required for the Development of NK T Cutting Edge: The Ets1 Transcription Factor (2000) (0)
- Serial Innovation to Bring Transformative Precision Medicines to People With Serious Diseases: A Conversation With Jeffrey Leiden, MD, PhD. (2020) (0)
- Identification and Functional Characterization of the Human T-Cell Receptor Gene Transcriptional Enhancer: Common Nuclear Proteins Interact with the Transcriptional Regulatory Elements of the T-Cell Receptor ox and Genes (0)
- IS021 Keynote Lecture: Gene Therapy for Cardiovascular Disease : Recent Advances, Rernaining Hurdles (2000) (0)
- Regulation of herpesvirus gene expression in biochemical transformed cells: investigations of virus-specified regulatory functions. (1975) (0)
- Gene Therapy for Cardiovascular Disease: Realistic Possibilities for the Future (1993) (0)
- 9.7-04 A T cell receptor Vb gene fragment related RFLP defines a polymorphic marker in Northern European populations (1989) (0)
- Evolutionary conservation of antigen recognition : The chicken T-cell receptor f 8 chain ( immunologic repertoire / gene rearrangement / DNA sequence ) (0)
- proteins.HMG-I(Y), and NF-kappa B family potential role of physical interactions between receptor alpha-chain gene expression: Regulation of cell-type-specific interleukin-2 (2013) (0)
- An Essential Role for Nuclear Factor (cid:107) B in Promoting Double Positive Thymocyte Apoptosis (1998) (0)
- Cloning andsequence analysis ofcomplementary DNA encoding an aberrantly rearranged humanT-cell ychain (1986) (0)
- Focus on Molecular Biology Structure , Function , and Regulation of Troponin C (2005) (0)
- Memory T Cells In Vitro and In Vivo Cytokines and Correlates with Survival of Krüppel-Like Factor Is Regulated by Expression of the Transcription Factor (1999) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Jeffrey m. Leiden?
Jeffrey m. Leiden is affiliated with the following schools: