Jeffrey m. Leiden

Jeffrey m. Leiden's AcademicInfluence.com Rankings

Jeffrey m. Leiden

Philosophy

#9627

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#13215

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#6594

World Rank

#8125

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philosophy Degrees

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Philosophy

Jeffrey m. Leiden's Degrees

Doctorate Medicine Harvard University
PhD Biological Chemistry University of Chicago

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Jeffrey m. Leiden's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. (2003) (2874)
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. (1997) (1102)
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. (1989) (683)
Immune responses to transgene–encoded proteins limit the stability of gene expression after injection of replication–defective adenovirus vectors (1996) (677)
Transcription factor GATA-3 is required for development of the T-cell lineage (1996) (667)
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. (1992) (562)
Function of GATA transcription factors in preadipocyte-adipocyte transition. (2000) (494)
LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. (1997) (429)
The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. (1997) (391)
The Ets-1 transcription factor is required for the development of natural killer cells in mice. (1998) (385)
Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. (1995) (382)
Expression of recombinant genes in myocardium in vivo after direct injection of DNA. (1990) (359)
Human GATA‐3: a lineage‐restricted transcription factor that regulates the expression of the T cell receptor alpha gene. (1991) (345)
Critical roles for transcription factor GATA-3 in thymocyte development. (2003) (337)
Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle (2001) (336)
Defective activation and survival of T cells lacking the Ets-1 transcription factor (1995) (335)
Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. (1994) (311)
Transcriptional regulation of T lymphocyte development and function. (1999) (304)
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. (1995) (295)
Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. (1999) (291)
Systemic delivery of recombinant proteins by genetically modified myoblasts. (1991) (286)
Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. (1998) (264)
Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB (1996) (258)
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins (1995) (257)
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. (1992) (254)
An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis (1999) (232)
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB (1993) (227)
Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc–dependent pathway (2001) (223)
Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart (1999) (220)
Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28 (1998) (215)
Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. (1993) (212)
Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. (1999) (205)
The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells (1994) (201)
A direct physical association between ETS and AP-1 transcription factors in normal human T cells. (1995) (191)
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. (1990) (191)
Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector. (1996) (185)
A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2 (2000) (178)
p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures (1997) (173)
Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. (1998) (159)
Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors (1994) (155)
Transcriptional regulation of T cell receptor genes. (1993) (153)
Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. (1999) (150)
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. (2000) (150)
Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells (1997) (147)
The role of Ets transcription factors in the development and function of the mammalian immune system. (1997) (138)
The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. (1994) (132)
Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus. (1994) (127)
CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. (1995) (125)
Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene (1992) (121)
A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle (1994) (120)
The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes. (1992) (120)
Rapid response (1998) (119)
A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells (1992) (118)
A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus. (1989) (115)
Regulation of excitatory transmission at hippocampal synapses by calbindin D28k. (1995) (113)
Evolutionary conservation of antigen recognition: the chicken T-cell receptor beta chain. (1990) (108)
Elf-1 binds to a critical element in a second CD4 enhancer (1994) (108)
Expression of GATA-3 During Lymphocyte Differentiation and Mouse Embryogenesis (1992) (108)
Accuracy of echocardiographic estimates of left ventricular mass in mice. (2001) (105)
Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. (1987) (103)
Gene therapy--promise, pitfalls, and prognosis. (1995) (103)
Cutting Edge: The Ets1 Transcription Factor Is Required for the Development of NK T Cells in Mice1 (2000) (100)
Structure and expression of the murine slow/cardiac troponin C gene. (1989) (98)
Evolutionarily conserved Ets family members display distinct DNA binding specificities [published erratum appears in J Exp Med 1993 Sep 1;178(3):1133] (1992) (97)
Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo. (1997) (96)
Long-term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication-defective adenoviral vector. (1997) (95)
The Gene Encoding the Mitogen-responsive Phosphoprotein Dab2 Is Differentially Regulated by GATA-6 and GATA-4 in the Visceral Endoderm* (2000) (93)
Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes (1990) (88)
Gene and stem cell therapies. (2001) (87)
Structure, Function, and Regulation of Troponin C (1991) (87)
Structure, expression and regulation of the murine 4F2 heavy chain. (1989) (84)
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus (1976) (79)
Friend of GATA 2 Physically Interacts with Chicken Ovalbumin Upstream Promoter-TF2 (COUP-TF2) and COUP-TF3 and Represses COUP-TF2-dependent Activation of the Atrial Natriuretic Factor Promoter* (2001) (78)
Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I (2000) (77)
Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions (2001) (76)
Characterization of murine BATF: a negative regulator of activator protein‐1 activity in the thymus (2001) (75)
Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation (1988) (73)
A Protein Kinase C-, Ras-, and RSK2-dependent Signal Transduction Pathway Activates the cAMP-responsive Element-binding Protein Transcription Factor following T Cell Receptor Engagement* (1998) (71)
Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression. (1989) (69)
Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice. (1993) (68)
Adenovirus-Mediated Transfer of the Herpes Simplex Virus Thymidine Kinase Gene Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation Following Balloon Angioplasty of the Rat Carotid Artery (1995) (67)
The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins (1989) (61)
The genetics of dilated cardiomyopathy--emerging clues to the puzzle. (1997) (57)
Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen. (1986) (57)
Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21 (1997) (56)
Transcriptional regulation of T-cell genes during T-cell development. (1994) (55)
The structure and regulation of expression of the murine fast skeletal troponin C gene. Identification of a developmentally regulated, muscle-specific transcriptional enhancer. (1990) (55)
NF-κB Is Required for the Positive Selection of CD8+ Thymocytes1 (2000) (55)
Partial primary structure of the alpha and beta chains of human tumor T-cell receptors. (1985) (53)
Transcriptional regulation during T-cell development: the α TCR gene as a molecular model (1992) (52)
Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. (1986) (51)
Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements (1990) (51)
Adenovirus-Mediated Expression of a Ribozyme to c-mybmRNA Inhibits Smooth Muscle Cell Proliferation and Neointima Formation In Vivo (1999) (49)
Evaluation of ventricular and arterial hemodynamics in anesthetized closed-chest mice. (1997) (45)
Identification of a second ATF/CREB-like element in the herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) promoter. (1994) (45)
A T-cell-specific transcriptional enhancer element 3 ' of C . in the human T-cell receptor a locus (45)
Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography. (1999) (43)
Biocompatibility of cardiovascular gene delivery catheters with adenovirus vectors: an important determinant of the efficiency of cardiovascular gene transfer. (2000) (43)
Muscle-based gene therapy: realistic possibilities for the future. (1996) (42)
Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines (1980) (41)
Recent advances in skeletal-muscle-based gene therapy. (1998) (37)
Expression Pattern of the Ets-related Transcription Factor Elf-1 (1998) (37)
Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms (1988) (36)
GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer (1994) (36)
Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule (1996) (34)
Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes. (1989) (33)
Human gene therapy: the good, the bad, and the ugly. (2000) (31)
Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts. (1999) (31)
Gene transfer into cardiac myocytes in vivo. (1991) (30)
17 – GATA Transcription Factors and Cardiac Development (1999) (28)
Safe and effective regulation of hematocrit by gene gun administration of an erythropoietin-encoding DNA plasmid. (1999) (26)
NF-kappa B is required for the positive selection of CD8+ thymocytes. (2000) (25)
Cytotoxic T Lymphocyte Antigen 4 ( CTLA 4 ) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD 28-deficient Mice : CTLA 4 Can Function Independently of CD 28 By (1998) (25)
Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment (1986) (25)
A critical role for NF-kappaB transcription factors in the development of CD8+ memory-phenotype T cells. (2003) (24)
Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset (2004) (24)
Effects of cardiac thin filament Ca2+: statistical mechanical analysis of a troponin C site II mutant. (1996) (23)
The Ets1 transcription factor is required for the development of NK T cells in mice. (2000) (22)
The GATA-4 transcription factor transactivates the cardiac-specific troponin C promoter-enhancer in non-muscle cells. (1995) (19)
Inhibition of βARK1 restores impaired biochemical β-adrenergic receptor responsiveness but does not rescue CREBA133 induced cardiomyopathy (2002) (19)
The left ventricular stress-velocity relation in transgenic mice expressing a dominant negative CREB transgene in the heart. (2001) (17)
The T alpha 2 nuclear protein binding site from the human T cell receptor alpha enhancer functions as both a T cell-specific transcriptional activator and repressor (1990) (17)
Effects of exercise training on LV performance and mortality in a murine model of dilated cardiomyopathy. (2000) (15)
Somatic gene therapy for cardiovascular disease Recent advances. (1994) (13)
Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular model. (1992) (12)
Cardiac Electrophysiologic Abnormalities in the CREBA133 Transgenic Mouse Model of Idiopathic Dilated Cardiomyopathy (2003) (11)
Gene Therapy Enters Adolescence (1999) (10)
REGULATION OF T CELL RECEPTOR GENES (1993) (9)
Adenovirus-mediated gene transfer as an in vivo probe of lipoprotein metabolism. (1996) (9)
LKLF and FasL expression: correctiona and clarification. (1997) (8)
The complete primary structure of the T -Cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone (2004) (8)
Beating the odds: a cardiomyocyte cell line at last. (1999) (7)
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. (2002) (7)
In Vivo Gene Transfer into the Heart (1994) (5)
NF-kB Is Required for the Positive Selection of CD8 Thymocytes (2000) (5)
Canaries, coal mines and the drug supply (2008) (4)
Polymorphic markers related to a single Tcrb-V6 gene segment (2004) (4)
T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor α, β, or γ genes (2004) (4)
The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells. (1989) (3)
T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor alpha, beta, or gamma genes. (1988) (3)
Mapping of the herpes simplex virus DNA sequences in three herpes simplex virus thymidine kinase-transformed cell lines. (1978) (3)
Revised 3 / 23 / 00 The Gene Encoding the Mitogen-Responsive Phosphoprotein Dab 2 is Differentially Regulated by GATA-6 and GATA-4 in the Visceral Endoderm (2000) (2)
Direct gene transfer into cardiac myocytes in vivo (1992) (2)
DNA fragments of altered electrophoretic mobility in leukemia samples can arise from double-strand DNA breaks at nuclease hypersensitive sites of active genes. (1993) (1)
Identification andFunctional Characterization oftheHumanT-Cell ReceptorGeneTranscriptional Enhancer: CommonNuclear Proteins Interact withtheTranscriptional Regulatory Elements oftheT-Cell Receptor oxand Genes (1990) (1)
The Presence and Expression of Herpes Simplex Virus DNA in Transformed Cells (1978) (1)
Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell y chain (2003) (1)
07 Depressed cross-bridge kinetics in dominant-negative CREB133 transgenic mouse model of dilated cardiomyopathy (2002) (0)
Gene therapy for vascular proliferative disorders. (1996) (0)
Erratum (2021) (0)
7.4-02 Identification and characterization of a human T-cell receptor β chain transcriptional element (1989) (0)
Molecular cloning of a complementary dna encoding the heavy chain of the 4f2 cell surface antigen (1987) (0)
In vivo studies of transcriptional regulation in cardiac myocytes using direct gene transfer into myocardium (1992) (0)
Mapping of the HSV sequences in transformed cells (1981) (0)
Viral IL-10 Gene Transfer Inhibition of Collagen-Induced Arthritis in Mice (1998) (0)
Gene therapy for cardiovascular disease: Promises, pitfalls and prognosis (1999) (0)
Elf-1 Binds to a Critical Element in a Second CD4 Enhancer (1994) (0)
Direct Injection of DNA (2005) (0)
Erratum (1967) (0)
Abstracts of papers presented at the 2000 Meeting on Gene Therapy, September 25-September 29, 2000 (2000) (0)
Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector ( gene therapy / anemia / skeletal muscle / serum protein ) (2005) (0)
Is Required for the Development of NK T Cutting Edge: The Ets1 Transcription Factor (2000) (0)
Serial Innovation to Bring Transformative Precision Medicines to People With Serious Diseases: A Conversation With Jeffrey Leiden, MD, PhD. (2020) (0)
Identification and Functional Characterization of the Human T-Cell Receptor Gene Transcriptional Enhancer: Common Nuclear Proteins Interact with the Transcriptional Regulatory Elements of the T-Cell Receptor ox and Genes (0)
IS021 Keynote Lecture: Gene Therapy for Cardiovascular Disease : Recent Advances, Rernaining Hurdles (2000) (0)
Regulation of herpesvirus gene expression in biochemical transformed cells: investigations of virus-specified regulatory functions. (1975) (0)
Gene Therapy for Cardiovascular Disease: Realistic Possibilities for the Future (1993) (0)
9.7-04 A T cell receptor Vb gene fragment related RFLP defines a polymorphic marker in Northern European populations (1989) (0)
Evolutionary conservation of antigen recognition : The chicken T-cell receptor f 8 chain ( immunologic repertoire / gene rearrangement / DNA sequence ) (0)
proteins.HMG-I(Y), and NF-kappa B family potential role of physical interactions between receptor alpha-chain gene expression: Regulation of cell-type-specific interleukin-2 (2013) (0)
An Essential Role for Nuclear Factor (cid:107) B in Promoting Double Positive Thymocyte Apoptosis (1998) (0)
Cloning andsequence analysis ofcomplementary DNA encoding an aberrantly rearranged humanT-cell ychain (1986) (0)
Focus on Molecular Biology Structure , Function , and Regulation of Troponin C (2005) (0)
Memory T Cells In Vitro and In Vivo Cytokines and Correlates with Survival of Krüppel-Like Factor Is Regulated by Expression of the Transcription Factor (1999) (0)

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What Schools Are Affiliated With Jeffrey m. Leiden?

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